PharmaCoNets of Letrozole (SPCN: 275.81 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Letrozolehsa00010Glycolysis / Gluconeogenesis1.89E-035P04075, P14550, P11766, P07195, P60174ALDOA, AKR1A1, ADH5, LDHB, TPI1More
Letrozolehsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Letrozolehsa00030Pentose phosphate pathway3.76E-124P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Letrozolehsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Letrozolehsa00051Fructose and mannose metabolism2.63E-055P15121, P19367, P08237, P60174, P04075AKR1B1, HK1, PFKM, TPI1, ALDOAMore
Letrozolehsa00052Galactose metabolism4.25E-056P06280, P08237, O43451, P15121, P19367, Q14376GLA, PFKM, MGAM, AKR1B1, HK1, GALEMore
Letrozolehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Letrozolehsa00071Fatty acid degradation2.42E-034P11310, O75521, P11766, P33121ACADM, ECI2, ADH5, ACSL1More
Letrozolehsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Letrozolehsa00190Oxidative phosphorylation4.36E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Letrozolehsa00220Arginine biosynthesis8.15E-073P15104, P05089, P49448GLUL, ARG1, GLUD2More
Letrozolehsa00230Purine metabolism3.35E-022Q7LG56, P51828RRM2B, ADCY7More
Letrozolehsa00240Pyrimidine metabolism1.85E-022P31350, P04818RRM2, TYMSMore
Letrozolehsa00250Alanine, aspartate and glutamate metabolism3.77E-063Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Letrozolehsa00270Cysteine and methionine metabolism2.39E-022Q96RQ9, P40926IL4I1, MDH2More
Letrozolehsa00280Valine, leucine and isoleucine degradation1.93E-046P55809, Q9HCC0, Q96RQ9, P05166, Q02252, P11310OXCT1, MCCC2, IL4I1, PCCB, ALDH6A1, ACADMMore
Letrozolehsa00310Lysine degradation1.30E-067Q9NVH6, Q96KQ7, Q8NEZ4, Q13029, O15047, Q02809, P51648TMLHE, EHMT2, MLL3, PRDM2, SETD1A, PLOD1, ALDH3A2More
Letrozolehsa00330Arginine and proline metabolism2.73E-021P17707AMD1More
Letrozolehsa00340Histidine metabolism4.52E-021O95954FTCDMore
Letrozolehsa00350Tyrosine metabolism1.76E-042P28332, P07101ADH6, THMore
Letrozolehsa00380Tryptophan metabolism3.02E-021Q16613AANATMore
Letrozolehsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Letrozolehsa00471D-Glutamine and D-glutamate metabolism1.54E-032Q7Z3D6, P49448C14orf159, GLUD2More
Letrozolehsa00500Starch and sucrose metabolism1.38E-104O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Letrozolehsa00510N-Glycan biosynthesis1.10E-034O94777, P15907, Q9BVK2, Q9NR34DPM2, ST6GAL1, ALG8, MAN1C1More
Letrozolehsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Letrozolehsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Letrozolehsa00520Amino sugar and nucleotide sugar metabolism2.98E-053Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Letrozolehsa00531Glycosaminoglycan degradation3.78E-021P15586GNSMore
Letrozolehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate3.68E-021Q9Y2C2USTMore
Letrozolehsa00562Inositol phosphate metabolism4.54E-045Q9NRR6, P27987, O14732, P19174, P42338INPP5E, ITPKB, IMPA2, PLCG1, PIK3CBMore
Letrozolehsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.28E-032O94777, Q14442DPM2, PIGHMore
Letrozolehsa00564Glycerophospholipid metabolism4.50E-088P48651, Q9Y6K0, P35790, Q9Y259, P23743, P49619, O14494, Q3LIE5PTDSS1, CEPT1, CHKA, CHKB, DGKA, DGKG, PLPP1, ADPRMMore
Letrozolehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Letrozolehsa00590Arachidonic acid metabolism2.97E-021P09917ALOX5More
Letrozolehsa00591Linoleic acid metabolism3.68E-021P11712CYP2C9More
Letrozolehsa00600Sphingolipid metabolism2.65E-033Q9BX95, Q06136, P15289SGPP1, FVT1, ARSAMore
Letrozolehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.27E-072P06865, O75752HEXA, B3GALNT1More
Letrozolehsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Letrozolehsa00620Pyruvate metabolism9.80E-044P40926, P07195, P14550, P11766MDH2, LDHB, AKR1A1, ADH5More
Letrozolehsa00630Glyoxylate and dicarboxylate metabolism8.62E-104P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Letrozolehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Letrozolehsa00670One carbon pool by folate1.72E-053O95954, P04818, Q99707FTCD, TYMS, MTRMore
Letrozolehsa00730Thiamine metabolism1.32E-042P05186, P24666ALPL, ACP1More
Letrozolehsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Letrozolehsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Letrozolehsa00770Pantothenate and CoA biosynthesis3.10E-044O95498, O95497, Q6ZQY3, Q9NRN7VNN2, VNN1, GADL1, AASDHPPTMore
Letrozolehsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Letrozolehsa00790Folate biosynthesis2.18E-044Q92820, P05186, P07101, P42330GGH, ALPL, TH, AKR1C3More
Letrozolehsa00830Retinol metabolism2.40E-056P00325, P11766, P28332, P00352, Q9BPW9, O75911ADH1B, ADH5, ADH6, ALDH1A1, DHRS9, DHRS3More
Letrozolehsa00860Porphyrin and chlorophyll metabolism7.35E-053P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Letrozolehsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Letrozolehsa00910Nitrogen metabolism1.75E-042P15104, P49448GLUL, GLUD2More
Letrozolehsa00970Aminoacyl-tRNA biosynthesis8.29E-094O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Letrozolehsa00980Metabolism of xenobiotics by cytochrome P4504.50E-021P28332ADH6More
Letrozolehsa00982Drug metabolism - cytochrome P4504.50E-021P28332ADH6More
Letrozolehsa00983Drug metabolism - other enzymes1.07E-065P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Letrozolehsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Letrozolehsa01100Metabolic pathways8.37E-0876Q9NR34, Q9Y234, P35790, Q9Y259, P05089, P21953, Q16772, Q9UJ14, P30041, P15104, P19367, P42338, Q9Y217, P48426, P27987, Q96DU7, P22557, Q6ZQY3, P32320, Q08828, Q13956, Q02153, P20839, P22748, P40926, P55809, P06280, O94777, Q16875, O43286, O43451, P53004, Q9Y6K0, P05186, P24666, P15121, P08237, P49619, Q86XP1, O95861, Q96RQ9, O95954, Q9HCC0, P33121, Q02318, Q9UHK6, Q86VZ5, Q96G23, P09917, P48651, Q9BVK2, P57054, Q14442, Q9UBX8, Q9UNP4, Q9H4F1, Q9BX95, Q9BRR6, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737, Q969G6, P05166, P14927, P12074, P05496, Q99437, O15239, O15047, Q9NVH6MAN1C1, LIPT1, CHKA, CHKB, ARG1, BCKDHB, GSTA3, GGTL3, PRDX6, GLUL, HK1, PIK3CB, MTMR6, PIP4K2A, ITPKB, ITPKC, ALAS2, GADL1, CDA, ADCY1, PDE6H, GUCY1B3, IMPDH1, CA4, MDH2, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, BLVRA, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKG, DGKH, BPNT1, IL4I1, FTCD, MCCC2, ACSL1, CYP27A1, AMACR, SGMS1, LASS2, ALOX5, PTDSS1, ALG8, PIGP, PIGH, B4GALT6, ST3GAL5, ST6GALNAC4, SGPP1, ADPGK, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGL, RFK, PCCB, UQCRB, COX6A1, ATP5G1, ATP6V0B, NDUFA1, SETD1A, TMLHEMore
Letrozolehsa01200Carbon metabolism2.13E-022P52209, P37837PGD, TALDO1More
Letrozolehsa01212Fatty acid metabolism4.62E-022P33121, P11310ACSL1, ACADMMore
Letrozolehsa01230Biosynthesis of amino acids2.18E-067P51854, P60891, Q99707, P50213, P05089, P15104, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, GLUL, TALDO1More
Letrozolehsa01240Biosynthesis of cofactors2.85E-047Q969G6, P13716, P36551, P22557, O60701, P14618, Q9Y234RFK, ALAD, CPOX, ALAS2, UGDH, PKM2, LIPT1More
Letrozolehsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Letrozolehsa01522Endocrine resistance1.02E-047P04049, Q9UM47, P04637, P42773, P08069, P10415, Q13323RAF1, NOTCH3, TP53, CDKN2C, IGF1R, BCL2, BIKMore
Letrozolehsa01523Antifolate resistance1.91E-044P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Letrozolehsa01524Platinum drug resistance2.37E-058Q13489, Q14790, P48023, P78417, P40692, P23025, P52701, P31751BIRC3, CASP8, FASLG, GSTO1, MLH1, XPA, MSH6, AKT2More
Letrozolehsa02010ABC transporters2.17E-031Q8IZY2ABCA7More
Letrozolehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Letrozolehsa03010Ribosome1.15E-1320P26373, P62753, P42677, P25398, P32969, P62917, P46776, P46777, Q9H0U6, Q07020, Q9UHA3, P62899, P62910, P18077, P61927, Q02878, P36578, P27635, P05386, P23396RPL13, RPS6, RPS27, RPS12, RPL9, RPL8, RPL27A, RPL5, MRPL18, RPL18, RSL24D1, RPL31, RPL32, RPL35A, RPL37, RPL6, RPL4, RPL10, RPLP1, RPS3More
Letrozolehsa03013RNA transport1.12E-2330P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, Q9H777, P11940, P20042, Q14240, Q9BZI7, P23588, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, ELAC1, PABPC1, EIF2S2, EIF4A2, UPF3B, EIF4B, TACC3, EIF2B1, FMR1, FXR1More
Letrozolehsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Letrozolehsa03020RNA polymerase7.29E-084P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Letrozolehsa03040Spliceosome1.18E-1119Q14562, O43143, O60508, P08579, Q15427, P26368, O75940, P38159, P61978, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, SF3B4, U2AF2, SMNDC1, RBMX, HNRPK, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Letrozolehsa03050Proteasome3.68E-021P55036PSMD4More
Letrozolehsa03060Protein export1.16E-104Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Letrozolehsa03320PPAR signaling pathway2.42E-034Q6PCB7, Q9UNU6, Q13133, Q02318SLC27A1, CYP8B1, NR1H3, CYP27A1More
Letrozolehsa03430Mismatch repair4.38E-021P20585MSH3More
Letrozolehsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Letrozolehsa03460Fanconi anemia pathway8.90E-043P40692, O60673, Q9UNA4MLH1, REV3L, POLIMore
Letrozolehsa04010MAPK signaling pathway8.69E-054P04049, P08069, Q9H2K8, Q12933RAF1, IGF1R, TAOK3, TRAF2More
Letrozolehsa04012ErbB signaling pathway3.54E-0610P21860, Q13153, P16333, Q13191, Q13557, P19174, O14944, P42338, P01106, P04049ERBB3, PAK1, NCK1, CBLB, CAMK2D, PLCG1, EREG, PIK3CB, MYC, RAF1More
Letrozolehsa04014Ras signaling pathway2.82E-0513P04049, P31751, P20827, Q9NRA1, P49767, P08069, Q13009, P17252, P0DP23, P62873, P63218, P50151, P19174RAF1, AKT2, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, PRKCA, CALM1, GNB1, GNG5, GNG10, PLCG1More
Letrozolehsa04015Rap1 signaling pathway1.56E-0511P04049, P20827, P49767, P08069, P06213, P11215, O00522, P31751, P0DP23, P17252, P19174RAF1, EFNA1, VEGFC, IGF1R, INSR, ITGAM, KRIT1, AKT2, CALM1, PRKCA, PLCG1More
Letrozolehsa04020Calcium signaling pathway2.57E-0916P27987, Q96DU7, Q08828, P21796, P45880, Q13557, P17252, P21860, P30679, P19174, P0DP24, P0DP23, P05141, P51828, P23634, P49767ITPKB, ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, PRKCA, ERBB3, GNA15, PLCG1, CALM2, CALM1, SLC25A5, ADCY7, ATP2B4, VEGFCMore
Letrozolehsa04022cGMP-PKG signaling pathway2.03E-0812Q02153, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Letrozolehsa04024cAMP signaling pathway1.08E-046Q08828, P51828, P31751, P0DP23, P04049, Q13153ADCY1, ADCY7, AKT2, CALM1, RAF1, PAK1More
Letrozolehsa04060Cytokine-cytokine receptor interaction6.46E-0517P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, P09341, P19875, P80075, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CXCL2, CCL8, CD4, TNFRSF25More
Letrozolehsa04061Viral protein interaction with cytokine and cytokine receptor1.84E-0610Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Letrozolehsa04062Chemokine signaling pathway4.74E-1021P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q13009, P14598, P42224, P04049, P25963, P49841CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, TIAM1, NCF1, STAT1, RAF1, NFKBIA, GSK3BMore
Letrozolehsa04064NF-kappa B signaling pathway3.88E-2026P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Letrozolehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Letrozolehsa04068FoxO signaling pathway4.41E-054P04049, P08069, P48023, Q96BR1RAF1, IGF1R, FASLG, SGK3More
Letrozolehsa04070Phosphatidylinositol signaling system1.97E-0811P19174, P0DP23, O14986, P23743, P49619, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252PLCG1, CALM1, PIP5K1B, DGKA, DGKG, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Letrozolehsa04071Sphingolipid signaling pathway3.85E-0611P04049, P17252, P21453, Q9H228, P01375, Q96G23, Q13362, Q9BX95, P10415, Q12933, Q02156RAF1, PRKCA, S1PR1, EDG8, TNF, LASS2, PPP2R5C, SGPP1, BCL2, TRAF2, PRKCEMore
Letrozolehsa04072Phospholipase D signaling pathway1.18E-0513P04049, P31751, P42338, Q9UQC2, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760RAF1, AKT2, PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Letrozolehsa04080Neuroactive ligand-receptor interaction3.76E-0713P08311, P78334, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, P30939, P14416, P07550, P35318CTSG, GABRE, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, HTR1F, DRD2, ADRB2, ADMMore
Letrozolehsa04110Cell cycle1.69E-0712Q9UBD5, P30260, P06493, O60566, Q14683, P04637, P49918, P30304, P33981, P42773, P01106, Q13547ORC3, CDC27, CDK1, BUB1B, SMC1A, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Letrozolehsa04114Oocyte meiosis2.64E-1111Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Letrozolehsa04115p53 signaling pathway4.19E-036P24522, O15151, Q13315, Q53FA7, O95067, P10415GADD45A, MDM4, ATM, TP53I3, CCNB2, BCL2More
Letrozolehsa04120Ubiquitin mediated proteolysis4.82E-032Q9UBT2, Q14669SAE2, TRIP12More
Letrozolehsa04136Autophagy - other4.46E-052O94817, Q9H1Y0ATG12, ATG5More
Letrozolehsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Letrozolehsa04140Autophagy - animal3.90E-0515P08069, Q9Y4H2, P42338, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, PIK3CB, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Letrozolehsa04141Protein processing in endoplasmic reticulum6.17E-0714P18848, Q12933, P30101, Q15436, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9H173, Q9UNL2ATF4, TRAF2, PDIA3, SEC23A, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SIL1, SSR3More
Letrozolehsa04142Lysosome1.89E-0613Q99437, P25774, O14773, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916, Q04900ATP6V0B, CTSS, TPP1, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2, CD164More
Letrozolehsa04144Endocytosis8.76E-0719Q13191, P0DMV8, P11142, Q9H444, O43633, O75351, P62491, P25024, Q96B97, P43250, Q6WKZ4, Q15438, Q8WU79, Q14161, P14784, O95219, O75154, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, CHMP2A, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, RAB11FIP1, PSCD1, SMAP1L, GIT2, IL2RB, SNX4, RAB11FIP3, SNX12, SNX5More
Letrozolehsa04145Phagosome7.76E-0715O75015, P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774FCGR3B, ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Letrozolehsa04146Peroxisome1.43E-024O00623, P56589, Q9UKG9, P33121PEX12, PEX3, CROT, ACSL1More
Letrozolehsa04150mTOR signaling pathway1.32E-035P08069, P04049, Q02750, Q9NQL2, P51812IGF1R, RAF1, MAP2K1, RRAGD, RPS6KA3More
Letrozolehsa04151PI3K-Akt signaling pathway1.09E-0621P62753, P21860, O43521, P04637, P27348, Q13362, P07900, P62873, P61952, P02452, P24821, Q16363, P22105, P23458, P01568, Q99941, P18848, Q96BR1, O00141, Q6ZUJ8, P56279RPS6, ERBB3, BCL2L11, TP53, YWHAQ, PPP2R5C, HSP90AA1, GNB1, GNG11, COL1A1, TNC, LAMA4, TNXB, JAK1, IFNA21, CREBL1, ATF4, SGK3, SGK, PIK3AP1, TCL1AMore
Letrozolehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Letrozolehsa04210Apoptosis4.57E-0413Q13315, P10415, Q13489, P25963, Q14790, P01375, P48023, P24522, Q16548, Q13077, Q14643, P42575, P04049ATM, BCL2, BIRC3, NFKBIA, CASP8, TNF, FASLG, GADD45A, BCL2A1, TRAF1, ITPR1, CASP2, RAF1More
Letrozolehsa04211Longevity regulating pathway1.55E-059Q12778, P31751, P08069, Q08828, P51828, P18848, Q9UEF7, Q96RR4, Q96KQ7FOXO1, AKT2, IGF1R, ADCY1, ADCY7, ATF4, KL, CAMKK2, EHMT2More
Letrozolehsa04213Longevity regulating pathway - multiple species1.70E-089P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Letrozolehsa04217Necroptosis3.64E-1016Q12933, P01568, P23458, Q13489, Q9NQC7, Q13546, P07900, P15104, P05141, P01584, P0C0S5, Q6FI13, Q13557, Q9H444, O75351, P45880TRAF2, IFNA21, JAK1, BIRC3, CYLD, RIPK1, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, CAMK2D, CHMP4B, VPS4B, VDAC2More
Letrozolehsa04218Cellular senescence1.96E-047P31751, P04049, P30281, P0DP23, P01889, P10321, P12236AKT2, RAF1, CCND3, CALM1, HLA-B, HLA-C, SLC25A6More
Letrozolehsa04260Cardiac muscle contraction4.20E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Letrozolehsa04261Adrenergic signaling in cardiomyocytes6.92E-0912P67936, Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP24, P0DP23, Q13557, P23634TPM4, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM2, CALM1, CAMK2D, ATP2B4More
Letrozolehsa04270Vascular smooth muscle contraction1.71E-0611P24723, Q04759, Q14643, P0DP23, P04049, Q08828, P51828, P22694, P35579, P35749, P35318PRKCH, PRKCQ, ITPR1, CALM1, RAF1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADMMore
Letrozolehsa04310Wnt signaling pathway2.28E-045P30279, Q13485, O43318, P17612, P67870CCND2, SMAD4, MAP3K7, PRKACA, CSNK2BMore
Letrozolehsa04330Notch signaling pathway4.48E-054Q92542, P49768, P46531, Q9UM47NCSTN, PSEN1, NOTCH1, NOTCH3More
Letrozolehsa04340Hedgehog signaling pathway2.58E-034P17612, P22694, Q13635, P10415PRKACA, PRKACB, PTCH1, BCL2More
Letrozolehsa04360Axon guidance4.08E-0512P16298, Q05397, P16333, P20827, O95631, P17252, Q13873, P42338, P04049, P19174, O14639, P24844PPP3CB, PTK2, NCK1, EFNA1, NTN1, PRKCA, BMPR2, PIK3CB, RAF1, PLCG1, ABLIM1, MYL9More
Letrozolehsa04370VEGF signaling pathway5.06E-157P19174, P16298, P31751, P42338, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PTK2, MAP2K1, RAF1More
Letrozolehsa04371Apelin signaling pathway6.52E-0714P62873, P63218, P50151, P61952, P31751, P04049, Q08828, P51828, Q13370, Q14344, P84022, P62753, P0DP23, P0DP24GNB1, GNG5, GNG10, GNG11, AKT2, RAF1, ADCY1, ADCY7, PDE3B, GNA13, SMAD3, RPS6, CALM1, CALM2More
Letrozolehsa04380Osteoclast differentiation2.25E-0710Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Letrozolehsa04390Hippo signaling pathway3.37E-055O95835, P04628, Q9UJU2, O43623, Q13489LATS1, WNT1, LEF1, SNAI2, BIRC3More
Letrozolehsa04392Hippo signaling pathway - multiple species2.11E-053O95835, Q13153, Q6V0I7LATS1, PAK1, FAT4More
Letrozolehsa04510Focal adhesion1.63E-035Q15942, P51636, P30281, P04049, P08069ZYX, CAV2, CCND3, RAF1, IGF1RMore
Letrozolehsa04512ECM-receptor interaction2.77E-056P02452, P24821, P07359, P26012, P08514, P16070COL1A1, TNC, GP1BA, ITGB8, ITGA2B, CD44More
Letrozolehsa04520Adherens junction1.81E-033Q13485, O43318, P08069SMAD4, MAP3K7, IGF1RMore
Letrozolehsa04540Gap junction5.01E-055Q13509, P68371, Q71U36, P04049, Q9NRA1TUBB3, TUBB2C, TUBA1A, RAF1, PDGFCMore
Letrozolehsa04550Signaling pathways regulating pluripotency of stem cells1.61E-035Q13873, P04049, Q02750, P08069, Q86SE9BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Letrozolehsa04610Complement and coagulation cascades1.51E-104P09871, P0C0L4, P20023, P05107C1S, C4A, CR2, ITGB2More
Letrozolehsa04611Platelet activation2.65E-056Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Letrozolehsa04612Antigen processing and presentation2.51E-1212P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P30101, P11142, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, PDIA3, HSPA8, TNFMore
Letrozolehsa04613Neutrophil extracellular trap formation4.44E-1028P19174, P17252, P04049, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q99878, Q93077, P62807, Q16778, O60814, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PLCG1, PRKCA, RAF1, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, H2AC14, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Letrozolehsa04620Toll-like receptor signaling pathway3.00E-065Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Letrozolehsa04621NOD-like receptor signaling pathway1.01E-0520P01584, P07900, Q14643, P23458, P01568, P45880, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, P29728, Q05823, P01375, P09341, P49913, P12838IL1B, HSP90AA1, ITPR1, JAK1, IFNA21, VDAC2, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA4More
Letrozolehsa04622RIG-I-like receptor signaling pathway1.16E-085P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Letrozolehsa04623Cytosolic DNA-sensing pathway8.50E-146P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2More
Letrozolehsa04625C-type lectin receptor signaling pathway4.61E-0810Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Letrozolehsa04630JAK-STAT signaling pathway1.01E-048P01106, P31751, P42224, P23458, P14784, P16871, Q13651, P04049MYC, AKT2, STAT1, JAK1, IL2RB, IL7R, IL10RA, RAF1More
Letrozolehsa04640Hematopoietic cell lineage1.16E-1117P13612, P07359, P08514, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375ITGA4, GP1BA, ITGA2B, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNFMore
Letrozolehsa04650Natural killer cell mediated cytotoxicity1.75E-2719P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Letrozolehsa04657IL-17 signaling pathway1.88E-0814P25963, P07900, P08238, O00463, Q12933, Q07955, Q16539, P49841, P09341, P14780, P04141, P80188, P01375, P06702NFKBIA, HSP90AA1, HSP90AB1, TRAF5, TRAF2, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, CSF2, LCN2, TNF, S100A9More
Letrozolehsa04658Th1 and Th2 cell differentiation2.19E-3417P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, RUNX3More
Letrozolehsa04659Th17 cell differentiation2.67E-2619P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Letrozolehsa04660T cell receptor signaling pathway3.11E-2520P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Letrozolehsa04662B cell receptor signaling pathway3.04E-1213P31751, P42338, P20023, P60033, P13164, P16298, Q8WV28, P07948, P11912, P21854, Q8N149, Q02750, P04049AKT2, PIK3CB, CR2, CD81, IFITM1, PPP3CB, BLNK, LYN, CD79A, CD72, LILRA2, MAP2K1, RAF1More
Letrozolehsa04664Fc epsilon RI signaling pathway4.09E-0810P01375, P31751, P04141, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917TNF, AKT2, CSF2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5More
Letrozolehsa04666Fc gamma R-mediated phagocytosis4.61E-034P08637, O75015, P04049, P06396FCGR3A, FCGR3B, RAF1, GSNMore
Letrozolehsa04668TNF signaling pathway7.88E-0714P01375, Q12933, O00463, Q13489, Q16539, P25963, Q99941, P18848, P01584, P20749, Q13077, P14780, P20333, O95429TNF, TRAF2, TRAF5, BIRC3, MAPK14, NFKBIA, CREBL1, ATF4, IL1B, BCL3, TRAF1, MMP9, TNFRSF1B, BAG4More
Letrozolehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Letrozolehsa04672Intestinal immune network for IgA production4.27E-022P13765, P13612HLA-DOB, ITGA4More
Letrozolehsa04710Circadian rhythm4.86E-021O15516CLOCKMore
Letrozolehsa04713Circadian entrainment1.49E-0710P0DP23, P0DP24, Q13557, Q02153, P62873, P63218, P50151, P61952, Q08828, P51828CALM1, CALM2, CAMK2D, GUCY1B3, GNB1, GNG5, GNG10, GNG11, ADCY1, ADCY7More
Letrozolehsa04714Thermogenesis4.42E-024Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Letrozolehsa04720Long-term potentiation2.77E-1110Q13557, P16298, P0DP23, P0DP24, Q15418, P51812, P18848, Q08828, Q02750, P04049CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1More
Letrozolehsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Letrozolehsa04722Neurotrophin signaling pathway9.79E-067Q05655, P31751, P04049, P52566, P51617, P10415, P0DP23PRKCD, AKT2, RAF1, ARHGDIB, IRAK1, BCL2, CALM1More
Letrozolehsa04723Retrograde endocannabinoid signaling3.71E-024P62873, P61952, Q08828, O15239GNB1, GNG11, ADCY1, NDUFA1More
Letrozolehsa04724Glutamatergic synapse1.34E-067O15399, Q08828, P62873, P63218, P50151, P61952, P15104GRIN2D, ADCY1, GNB1, GNG5, GNG10, GNG11, GLULMore
Letrozolehsa04725Cholinergic synapse5.48E-0610Q08828, P51828, P62873, P63218, P50151, P61952, P18848, Q13557, P42338, P31751ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, ATF4, CAMK2D, PIK3CB, AKT2More
Letrozolehsa04726Serotonergic synapse5.74E-035P62873, P63218, P50151, P09917, P04049GNB1, GNG5, GNG10, ALOX5, RAF1More
Letrozolehsa04727GABAergic synapse1.20E-099Q08828, P51828, P62873, P63218, P50151, P61952, P15104, P46459, Q15111ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, GLUL, NSF, PLCL1More
Letrozolehsa04728Dopaminergic synapse1.26E-0918P14416, P62873, P63218, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP24, P0DP23, O15516, P48058DRD2, GNB1, GNG5, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM2, CALM1, CLOCK, GRIA4More
Letrozolehsa04730Long-term depression4.37E-034Q14344, P08069, P04049, P07948GNA13, IGF1R, RAF1, LYNMore
Letrozolehsa04740Olfactory transduction4.52E-054P62873, Q13557, P0DP23, P0DP24GNB1, CAMK2D, CALM1, CALM2More
Letrozolehsa04742Taste transduction1.18E-032P30939, P17612HTR1F, PRKACAMore
Letrozolehsa04744Phototransduction1.48E-103P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Letrozolehsa04750Inflammatory mediator regulation of TRP channels2.50E-1111P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM2, CALM1More
Letrozolehsa04810Regulation of actin cytoskeleton1.78E-026Q13009, P04049, P11215, P16144, P60709, P01042TIAM1, RAF1, ITGAM, ITGB4, ACTB, KNG1More
Letrozolehsa04910Insulin signaling pathway2.40E-053P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Letrozolehsa04911Insulin secretion4.38E-085Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Letrozolehsa04912GnRH signaling pathway5.04E-067Q08828, P51828, P18848, Q9Y6R4, P0DP23, P04049, P45985ADCY1, ADCY7, ATF4, MAP3K4, CALM1, RAF1, MAP2K4More
Letrozolehsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Letrozolehsa04914Progesterone-mediated oocyte maturation1.42E-096P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Letrozolehsa04915Estrogen signaling pathway1.37E-1012P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, P0DP24, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, CALM2, NCOA1More
Letrozolehsa04916Melanogenesis7.31E-044P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Letrozolehsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Letrozolehsa04918Thyroid hormone synthesis2.47E-045Q08828, Q99941, P18848, P02768, P05543ADCY1, CREBL1, ATF4, ALB, SERPINA7More
Letrozolehsa04919Thyroid hormone signaling pathway1.21E-047P19174, P04049, P42224, P60709, Q13547, Q9UM47, P01106PLCG1, RAF1, STAT1, ACTB, HDAC1, NOTCH3, MYCMore
Letrozolehsa04920Adipocytokine signaling pathway1.22E-025P25963, P33121, Q04759, P31751, P01375NFKBIA, ACSL1, PRKCQ, AKT2, TNFMore
Letrozolehsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Letrozolehsa04922Glucagon signaling pathway4.86E-044P14618, P06737, P31751, P0DP23PKM2, PYGL, AKT2, CALM1More
Letrozolehsa04923Regulation of lipolysis in adipocytes4.29E-077Q08828, P51828, P07550, P06213, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, INSR, PIK3CB, IRS2, AKT2More
Letrozolehsa04924Renin secretion3.14E-054P22694, P07550, Q14643, P0DP23PRKACB, ADRB2, ITPR1, CALM1More
Letrozolehsa04925Aldosterone synthesis and secretion3.39E-108Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, CAMK2D, ATP2B4More
Letrozolehsa04926Relaxin signaling pathway1.62E-0714P31751, P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P49767, Q08828, P51828, P04049, P30679, P49407AKT2, PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, GNA15, ARRB1More
Letrozolehsa04927Cortisol synthesis and secretion2.32E-054Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Letrozolehsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Letrozolehsa04929GnRH secretion6.93E-064P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Letrozolehsa04930Type II diabetes mellitus6.29E-053P06213, Q05655, Q02156INSR, PRKCD, PRKCEMore
Letrozolehsa04932Non-alcoholic fatty liver disease3.31E-1112P31751, Q14790, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, O95298, P19404AKT2, CASP8, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2, NDUFV2More
Letrozolehsa04934Cushing syndrome6.22E-096Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Letrozolehsa04935Growth hormone synthesis, secretion and action5.87E-046Q08828, P51828, P04049, P18848, P31751, P45985ADCY1, ADCY7, RAF1, ATF4, AKT2, MAP2K4More
Letrozolehsa04940Type I diabetes mellitus1.55E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Letrozolehsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Letrozolehsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Letrozolehsa04966Collecting duct acid secretion2.17E-031P00918CA2More
Letrozolehsa04970Salivary secretion4.02E-1011P07550, Q08828, P51828, P22694, Q14643, P23634, P17252, P0DP24, P0DP23, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM2, CALM1, GUCY1B3, CAMPMore
Letrozolehsa04971Gastric acid secretion1.49E-086Q08828, P51828, P15311, P0DP24, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM2, CALM1, CAMK2DMore
Letrozolehsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Letrozolehsa04974Protein digestion and absorption1.22E-032Q7Z2H8, P02452SLC36A1, COL1A1More
Letrozolehsa04975Fat digestion and absorption1.43E-031O14494PLPP1More
Letrozolehsa04976Bile secretion2.26E-056O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Letrozolehsa04979Cholesterol metabolism1.37E-023P38571, P61916, P45880LIPA, NPC2, VDAC2More
Letrozolehsa05010Alzheimer disease3.15E-1021P49768, Q92542, O15239, O95298, P19404, P05496, P13073, P12074, Q00535, O75460, P0DP23, P01584, Q12933, P18848, O15169, P67870, P31751, P05141, P45880, P28070, P43686PSEN1, NCSTN, NDUFA1, NDUFC2, NDUFV2, ATP5G1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, TRAF2, ATF4, AXIN1, CSNK2B, AKT2, SLC25A5, VDAC2, PSMB4, PSMC4More
Letrozolehsa05012Parkinson disease3.79E-0519O15239, O95298, P13073, P12074, P05496, P05141, P12236, P60604, O75460, P18848, P28070, P43686, P19174, P0DP23, P0DP24, Q13557, Q71U36, Q13509, P68371NDUFA1, NDUFC2, COX4I1, COX6A1, ATP5G1, SLC25A5, SLC25A6, UBE2G2, ERN1, ATF4, PSMB4, PSMC4, PLCG1, CALM1, CALM2, CAMK2D, TUBA1A, TUBB3, TUBB2CMore
Letrozolehsa05014Amyotrophic lateral sclerosis4.18E-025P19404, P12074, O75460, P28070, Q8TEV9NDUFV2, COX6A1, ERN1, PSMB4, SMCR8More
Letrozolehsa05016Huntington disease1.51E-0612O95298, P19404, P13073, P12074, P24928, P30876, P62487, P05141, P45880, O75460, P28070, O00232NDUFC2, NDUFV2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, VDAC2, ERN1, PSMB4, PSMD12More
Letrozolehsa05017Spinocerebellar ataxia1.88E-049Q92915, O75460, Q8TB72, O15399, P42338, P31751, P28070, P05141, P21796FGF14, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1More
Letrozolehsa05020Prion disease2.49E-0819P01584, P46531, P0DMV8, P11142, O15239, O95298, P05496, P13073, P12074, Q92736, P18848, P05141, P12236, P45880, P28070, P43686, O60282, P67870, Q99941IL1B, NOTCH1, HSPA1A, HSPA8, NDUFA1, NDUFC2, ATP5G1, COX4I1, COX6A1, RYR2, ATF4, SLC25A5, SLC25A6, VDAC2, PSMB4, PSMC4, KIF5C, CSNK2B, CREBL1More
Letrozolehsa05022Pathways of neurodegeneration - multiple diseases1.42E-0826P67870, O15239, O95298, P19404, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, Q12933, P05141, P45880, Q15078, Q00535, O15169, P01584, P49768, O15020, P0DP24, P0DP23, Q13557, P62987, P28070, P43686CSNK2B, NDUFA1, NDUFC2, NDUFV2, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, TRAF2, SLC25A5, VDAC2, CDK5R1, CDK5, AXIN1, IL1B, PSEN1, SPTBN2, CALM2, CALM1, CAMK2D, UBA52, PSMB4, PSMC4More
Letrozolehsa05030Cocaine addiction5.99E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Letrozolehsa05031Amphetamine addiction4.45E-055P0DP24, P0DP23, Q13557, Q99941, P18848CALM2, CALM1, CAMK2D, CREBL1, ATF4More
Letrozolehsa05032Morphine addiction1.20E-036P62873, P63218, P50151, Q13370, P78334, P32298GNB1, GNG5, GNG10, PDE3B, GABRE, GRK4More
Letrozolehsa05033Nicotine addiction4.01E-021P78334GABREMore
Letrozolehsa05034Alcoholism8.97E-0614P07101, Q99941, P18848, Q13547, P0DP24, P0DP23, P62873, P61952, P04049, P0C0S5, Q93077, P62807, Q16778, O60814TH, CREBL1, ATF4, HDAC1, CALM2, CALM1, GNB1, GNG11, RAF1, H2AFZ, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12More
Letrozolehsa05100Bacterial invasion of epithelial cells3.14E-033Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Letrozolehsa05110Vibrio cholerae infection2.06E-055Q13488, Q99437, P17252, P19174, P17612TCIRG1, ATP6V0B, PRKCA, PLCG1, PRKACAMore
Letrozolehsa05120Epithelial cell signaling in Helicobacter pylori infection1.37E-1513Q16539, P25963, Q13488, Q99437, Q13153, P09341, P19875, P10145, P19174, P25024, P25025, P41240, P07948MAPK14, NFKBIA, TCIRG1, ATP6V0B, PAK1, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2, CSK, LYNMore
Letrozolehsa05130Pathogenic Escherichia coli infection3.26E-0412Q71U36, P16333, Q13509, P68371, P60709, Q14344, P25963, P04406, P29350, Q15438, P35579, P55061TUBA1A, NCK1, TUBB3, TUBB2C, ACTB, GNA13, NFKBIA, GAPDH, PTPN6, PSCD1, MYH9, TEGTMore
Letrozolehsa05131Shigellosis1.11E-0521P01375, P25963, Q12933, O00463, Q13546, Q05655, Q02156, Q04759, Q9UDY8, Q9NQL2, Q9H1Y0, P0CG47, Q14141, Q96JJ3, Q05397, Q14643, Q12778, Q13315, P10415, Q96A32, P07737TNF, NFKBIA, TRAF2, TRAF5, RIPK1, PRKCD, PRKCE, PRKCQ, MALT1, RRAGD, ATG5, UBB, SEPT6, ELMO2, PTK2, ITPR1, FOXO1, ATM, BCL2, MYLPF, PFN1More
Letrozolehsa05132Salmonella infection1.03E-1125P51617, P25963, P01375, P08238, P04049, Q9UJU2, P01106, P84095, P60709, O00471, Q13546, Q13489, P10415, P04406, O75369, P07737, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q71U36, Q13509, P68371, P49754IRAK1, NFKBIA, TNF, HSP90AB1, RAF1, LEF1, MYC, RHOG, ACTB, EXOC5, RIPK1, BIRC3, BCL2, GAPDH, FLNB, PFN1, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBA1A, TUBB3, TUBB2C, VPS41More
Letrozolehsa05133Pertussis1.55E-063P05107, P10145, P0C0L4ITGB2, IL8, C4AMore
Letrozolehsa05134Legionellosis1.46E-109P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Letrozolehsa05135Yersinia infection4.96E-0512Q05397, P51812, P13612, P06239, P19174, Q16539, Q02750, P01375, P42338, P49841, Q96JJ3, P01732PTK2, RPS6KA3, ITGA4, LCK, PLCG1, MAPK14, MAP2K1, TNF, PIK3CB, GSK3B, ELMO2, CD8AMore
Letrozolehsa05140Leishmaniasis8.08E-1114P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Letrozolehsa05142Chagas disease2.70E-022P48023, Q14790FASLG, CASP8More
Letrozolehsa05143African trypanosomiasis7.99E-052P69905, P68871HBA2, HBBMore
Letrozolehsa05144Malaria5.31E-099P60033, P69905, P68871, O60603, P01375, P05107, P35443, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL8, KLRK1More
Letrozolehsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Letrozolehsa05146Amoebiasis8.02E-2012P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Letrozolehsa05150Staphylococcus aureus infection5.41E-0815P09871, P0C0L4, P21730, P21462, O75015, P31995, P13765, P13646, Q14532, P05107, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, FCGR2C, HLA-DOB, KRT13, KRT32, ITGB2, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Letrozolehsa05152Tuberculosis2.13E-0514P04049, Q13488, Q99437, P0DP23, P48382, O60603, P01375, P31751, P10415, P13765, P25774, P49913, Q9UDY8, P51617RAF1, TCIRG1, ATP6V0B, CALM1, RFX5, TLR2, TNF, AKT2, BCL2, HLA-DOB, CTSS, CAMP, MALT1, IRAK1More
Letrozolehsa05160Hepatitis C2.32E-033Q13546, P01568, P04049RIPK1, IFNA21, RAF1More
Letrozolehsa05161Hepatitis B4.54E-0412P17252, P04049, P14780, Q99941, P18848, P25963, P01375, P10415, P27348, P51617, O60603, Q14765PRKCA, RAF1, MMP9, CREBL1, ATF4, NFKBIA, TNF, BCL2, YWHAQ, IRAK1, TLR2, STAT4More
Letrozolehsa05162Measles5.20E-046P23458, P31751, P0DMV8, P01584, P67870, Q9NP90JAK1, AKT2, HSPA1A, IL1B, CSNK2B, RAB9BMore
Letrozolehsa05163Human cytomegalovirus infection2.07E-1329P31751, P04049, P01375, P25963, P62873, P63218, P50151, P61952, Q14643, P0DP23, P0DP24, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P30101, P61769, P01568AKT2, RAF1, TNF, NFKBIA, GNB1, GNG5, GNG10, GNG11, ITPR1, CALM1, CALM2, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, PDIA3, B2M, IFNA21More
Letrozolehsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Letrozolehsa05165Human papillomavirus infection2.80E-0410P02452, P24821, Q16363, P30281, Q9UM47, P01568, P01889, P10321, Q99437, P04628COL1A1, TNC, LAMA4, CCND3, NOTCH3, IFNA21, HLA-B, HLA-C, ATP6V0B, WNT1More
Letrozolehsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Letrozolehsa05167Kaposi sarcoma-associated herpesvirus infection2.79E-0917P01568, P31751, P42224, P25963, P62873, P62879, P63218, P50151, P19174, P16298, P04049, Q02750, P07948, P01106, P04141, P0DP23, P0CG47IFNA21, AKT2, STAT1, NFKBIA, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, RAF1, MAP2K1, LYN, MYC, CSF2, CALM1, UBBMore
Letrozolehsa05168Herpes simplex virus 1 infection9.19E-0522O00463, O60603, P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q16629, P30101, Q9Y2A4, Q13398, P51522, Q9NR11, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415TRAF5, TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, SFRS7, PDIA3, ZNF443, ZNF211, ZNF83, ZNF302, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Letrozolehsa05169Epstein-Barr virus infection1.95E-0719P20023, P13765, P01106, Q13547, Q92769, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, P42224, P01375, O60603, P29728, P07766, P09693, P20963CR2, HLA-DOB, MYC, HDAC1, HDAC2, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, STAT1, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Letrozolehsa05170Human immunodeficiency virus 1 infection2.13E-1127P31751, P04049, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, P01375, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P10415, Q13619, Q93034, Q9Y6Q5, P20333AKT2, RAF1, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Letrozolehsa05171Coronavirus disease - COVID-193.96E-0917P23396, P62753, P25398, P42677, P36578, Q02878, P62917, P32969, P27635, P26373, Q07020, P46776, P62899, P62910, P18077, P61927, P05386RPS3, RPS6, RPS12, RPS27, RPL4, RPL6, RPL8, RPL9, RPL10, RPL13, RPL18, RPL27A, RPL31, RPL32, RPL35A, RPL37, RPLP1More
Letrozolehsa05200Pathways in cancer6.57E-0930P08238, P42224, P25963, P19174, P01106, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, P52701, P14923, P30279, P10415, Q13077, P49767, P14921, P31751, P62873, P63218, P50151, Q14344, Q9UM47, P78417, O75293, P0DP23, P01568, P14784, P01042HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, MSH6, JUP, CCND2, BCL2, TRAF1, VEGFC, ETS1, AKT2, GNB1, GNG5, GNG10, GNA13, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1More
Letrozolehsa05202Transcriptional misregulation in cancer6.19E-1121Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Letrozolehsa05203Viral carcinogenesis6.61E-0615Q12933, Q99941, P18848, P30281, P27348, Q13547, Q15283, P06396, P12814, P01889, P10321, P06493, P62807, P33778, Q16778TRAF2, CREBL1, ATF4, CCND3, YWHAQ, HDAC1, RASA2, GSN, ACTN1, HLA-B, HLA-C, CDK1, HIST1H2BC, H2BC3, HIST2H2BEMore
Letrozolehsa05205Proteoglycans in cancer6.79E-0510Q13009, Q12955, O75369, P60709, P04049, P01106, P08069, P19174, P29350, P08962TIAM1, ANK3, FLNB, ACTB, RAF1, MYC, IGF1R, PLCG1, PTPN6, CD63More
Letrozolehsa05206MicroRNAs in cancer1.66E-0413P30304, P09493, P15311, P21860, P61978, P46531, Q9UM47, P63279, P22105, P20827, P17252, P19174, P04049CDC25A, TPM1, VIL2, ERBB3, HNRPK, NOTCH1, NOTCH3, UBE2I, TNXB, EFNA1, PRKCA, PLCG1, RAF1More
Letrozolehsa05210Colorectal cancer1.47E-049Q9UKG1, Q13485, P43246, P04049, P01106, P52701, P20585, P37173, O75293APPL1, SMAD4, MSH2, RAF1, MYC, MSH6, MSH3, TGFBR2, GADD45BMore
Letrozolehsa05211Renal cell carcinoma5.09E-053Q13153, P31751, P04049PAK1, AKT2, RAF1More
Letrozolehsa05212Pancreatic cancer1.31E-047P31751, P04049, Q15311, P23458, P42224, P84022, O75293AKT2, RAF1, RALBP1, JAK1, STAT1, SMAD3, GADD45BMore
Letrozolehsa05213Endometrial cancer4.41E-044O15169, P31751, Q02750, P04049AXIN1, AKT2, MAP2K1, RAF1More
Letrozolehsa05214Glioma5.77E-087P08069, P0DP23, P17252, P04049, P31751, P19174, O75293IGF1R, CALM1, PRKCA, RAF1, AKT2, PLCG1, GADD45BMore
Letrozolehsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Letrozolehsa05217Basal cell carcinoma2.90E-034Q13635, P04628, Q9UJU2, P24522PTCH1, WNT1, LEF1, GADD45AMore
Letrozolehsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Letrozolehsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Letrozolehsa05220Chronic myeloid leukemia9.63E-042P31751, P04049AKT2, RAF1More
Letrozolehsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Letrozolehsa05222Small cell lung cancer5.10E-037P31751, Q13489, P10415, P25963, Q13077, O00463, P24522AKT2, BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Letrozolehsa05223Non-small cell lung cancer3.49E-042P31751, P04049AKT2, RAF1More
Letrozolehsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Letrozolehsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Letrozolehsa05226Gastric cancer3.48E-044P04049, Q02750, P31751, O15169RAF1, MAP2K1, AKT2, AXIN1More
Letrozolehsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Letrozolehsa05231Choline metabolism in cancer1.18E-0910P04049, P31751, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494, P17252RAF1, AKT2, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1, PRKCAMore
Letrozolehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.09E-1517P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Letrozolehsa05310Asthma2.22E-083P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Letrozolehsa05321Inflammatory bowel disease1.18E-157O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Letrozolehsa05322Systemic lupus erythematosus1.26E-0614P08637, O75015, P08246, P08311, P01375, P10747, P13765, Q6FI13, P62807, P33778, Q16778, P14678, P12814, P05455FCGR3A, FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2BC, H2BC3, HIST2H2BE, SNRPB, ACTN1, SSBMore
Letrozolehsa05323Rheumatoid arthritis1.89E-047P01375, Q06643, P13765, P10747, P09341, P19875, O60603TNF, LTB, HLA-DOB, CD28, CXCL1, CXCL2, TLR2More
Letrozolehsa05330Allograft rejection2.83E-023P13765, P10747, P01375HLA-DOB, CD28, TNFMore
Letrozolehsa05332Graft-versus-host disease1.12E-135P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Letrozolehsa05340Primary immunodeficiency2.96E-046P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Letrozolehsa05410Hypertrophic cardiomyopathy3.63E-022P26012, P09493ITGB8, TPM1More
Letrozolehsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Letrozolehsa05414Dilated cardiomyopathy3.78E-034P54284, P26012, P09493, P26678CACNB3, ITGB8, TPM1, PLNMore
Letrozolehsa05415Diabetic cardiomyopathy4.10E-037P30405, Q15080, Q16718, O14521, Q16539, P14780, P37173PPIF, NCF4, NDUFA5, SDHD, MAPK14, MMP9, TGFBR2More
Letrozolehsa05418Fluid shear stress and atherosclerosis4.89E-0710Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Letrozole (SDC: 11.99)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11511CYP19A1AromataseReported00.815610.15882.5666
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
O95235KIF20AKinesinNonelike protein KIF20APredicted00.17140.016500.1187
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P07195LDHBLNonelactate dehydrogenase B chainPredicted00.01670.17490.2310.5892
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
Q9Y6R4MAP3K4MitogenNoneactivated protein kinase kinase kinase 4Predicted00.35280.24520.1730.8399
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
Q99759MAP3K3MitogenNoneactivated protein kinase kinase kinase 3Predicted00.35450.24520.43781.1055
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
Q9UEW8STK39STE20/SPS1Nonerelated prolineNonealanineNonerich protein kinasePredicted00.25730.245200.6191
Q96BR1SGK3Serine/threonineNoneprotein kinase Sgk3Predicted00.0260.26840.31140.8612
Q9H2K8TAOK3Serine/threonineNoneprotein kinase TAO3Predicted00.06460.24520.14870.6715
Q9P289STK26Serine/threonineNoneprotein kinase 26Predicted10.02850.262800.5399
Q9NQU5PAK6Serine/threonineNoneprotein kinase PAK 6Predicted00.4090.26690.50031.2386
Q8NI60CABC1Atypical kinase COQ8A, mitochondrialPredicted00.62760.245200.8043
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
Q86Z02HIPK1HomeodomainNoneinteracting protein kinase 1Predicted00.46310.28160.2181.0128
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P32298GRK4G proteinNonecoupled receptor kinase 4Predicted00.03520.23860.29480.7896
O43283MAP3K13MitogenNoneactivated protein kinase kinase kinase 13Predicted00.45650.24520.14870.8674
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
O95747OXSR1Serine/threonineNoneprotein kinase OSR1Predicted00.18390.245200.5825
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
O14976GAKCyclinNoneGNoneassociated kinasePredicted10.57280.256200.7989
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
Q9H422HIPK3HomeodomainNoneinteracting protein kinase 3Predicted00.3650.25080.2180.902
Q00536PCTK1CyclinNonedependent kinase 16Predicted00.27140.25600.6478
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
Q15831STK11Serine/threonineNoneprotein kinase STK11Predicted00.15110.24410.45491.0186
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
Q8IVW4CDKL3CyclinNonedependent kinaseNonelike 3Predicted00.41490.241600.6906
Q13873BMPR2Bone morphogenetic protein receptor typeNone2Predicted10.34760.24520.35481.019
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
O75460ERN1Serine/threonineNoneprotein kinase/endoribonuclease IRE1Predicted10.68060.29440.5571.4862
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
Q16566CAMK4Calcium/calmodulinNonedependent protein kinase type IVPredicted00.07180.24410.61761.1417
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
P07332FESTyrosineNoneprotein kinase Fes/FpsPredicted00.27220.26280.15130.8131
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
Q16513PKN2Serine/threonineNoneprotein kinase N2Predicted00.04210.27780.33910.9157
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P45985MAP2K4Dual specificity mitogenNoneactivated protein kinase kinase 4Predicted00.42480.24730.74031.4474
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
Q9Y6E0STK24Serine/threonineNoneprotein kinase 24Predicted00.54580.245200.7634
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
Q8IVH8MAP4K3MitogenNoneactivated protein kinase kinase kinase kinase 3Predicted00.38330.26730.14870.875
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
Q13523PRPF4BSerine/threonineNoneprotein kinase PRP4 homologPredicted00.13760.245200.5593
P49760CLK2Dual specificity protein kinase CLK2Predicted00.03030.295100.6053
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
O95835LATS1Serine/threonineNoneprotein kinase LATS1Predicted00.43320.24520.02170.7288
O94806PRKD3Serine/threonineNoneprotein kinase D3Predicted00.23120.24340.16920.7715
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Predicted00.04350.26350.24610.7947
P49281SLC11A2Natural resistanceNoneassociated macrophage protein 2Predicted10.33250.05050.26620.5334
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P42224STAT1Signal transducer and activator of transcription 1Nonealpha/betaPredicted10.22450.042511.1973
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
CYP19A1P11511IC500.89
CYP19A1P11511IC500.89
CYP19A1P11511IC501
CYP19A1P11511Ki0.02
CYP19A1P11511Ki2.2