PharmaCoNets of Letermovir (SPCN: 21.69 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Letermovirhsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Letermovirhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Letermovirhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Letermovirhsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Letermovirhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Letermovirhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Letermovirhsa02010ABC transporters4.48E-021Q8IZY2ABCA7More
Letermovirhsa04064NF-kappa B signaling pathway9.70E-0312O00463, P14778, P01584, P01375, Q04759, Q13077, Q16548, P06239, Q8WV28, P24522, P09341, Q9NQC7TRAF5, IL1R1, IL1B, TNF, PRKCQ, TRAF1, BCL2A1, LCK, BLNK, GADD45A, CXCL1, CYLDMore
Letermovirhsa04070Phosphatidylinositol signaling system2.96E-023P19174, P49619, P27987PLCG1, DGKG, ITPKBMore
Letermovirhsa04110Cell cycle2.90E-025P06493, P30304, P33981, P01106, Q13547CDK1, CDC25A, TTK, MYC, HDAC1More
Letermovirhsa04270Vascular smooth muscle contraction2.89E-022P35579, P35318MYH9, ADMMore
Letermovirhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Letermovirhsa04380Osteoclast differentiation2.05E-0312Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Letermovirhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Letermovirhsa04610Complement and coagulation cascades1.91E-031P0C0L4C4AMore
Letermovirhsa04613Neutrophil extracellular trap formation4.28E-0421P19174, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q93077, P62807, Q16778, O60814, P68431, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539PLCG1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Letermovirhsa04614Renin-angiotensin system7.48E-034P50052, P15144, P08311, O75787AGTR2, ANPEP, CTSG, ATP6AP2More
Letermovirhsa04625C-type lectin receptor signaling pathway8.11E-039Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Letermovirhsa04630JAK-STAT signaling pathway3.20E-024P01106, P42224, P14784, Q13651MYC, STAT1, IL2RB, IL10RAMore
Letermovirhsa04640Hematopoietic cell lineage4.31E-0210P13612, P14778, P27930, P15144, P11836, P09693, P01732, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD3G, CD8A, HLA-DOB, TNF, IL1BMore
Letermovirhsa04650Natural killer cell mediated cytotoxicity2.99E-0210P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Letermovirhsa04657IL-17 signaling pathway1.56E-028O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Letermovirhsa04658Th1 and Th2 cell differentiation4.98E-0515Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Letermovirhsa04659Th17 cell differentiation4.81E-0415Q04759, Q16539, P19174, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1More
Letermovirhsa04660T cell receptor signaling pathway1.11E-0211P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Letermovirhsa04664Fc epsilon RI signaling pathway7.22E-032Q9UQC2, P20292GAB2, ALOX5APMore
Letermovirhsa04750Inflammatory mediator regulation of TRP channels1.17E-028P14778, P01584, P51828, P22694, Q16539, Q14643, Q04759, P0DP24IL1R1, IL1B, ADCY7, PRKACB, MAPK14, ITPR1, PRKCQ, CALM2More
Letermovirhsa04912GnRH signaling pathway4.33E-026P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACBMore
Letermovirhsa04919Thyroid hormone signaling pathway1.64E-024P19174, P42224, Q13547, P01106PLCG1, STAT1, HDAC1, MYCMore
Letermovirhsa04962Vasopressin-regulated water reabsorption7.22E-032P52566, P62491ARHGDIB, RAB11AMore
Letermovirhsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Letermovirhsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Letermovirhsa05034Alcoholism4.50E-058Q13547, Q96RR4, Q93077, P62807, Q16778, O60814, P84243, P68431HDAC1, CAMKK2, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Letermovirhsa05133Pertussis3.51E-021P0C0L4C4AMore
Letermovirhsa05140Leishmaniasis2.29E-029P13612, O75015, P23458, P13765, O60603, P01375, P01584, Q16539, Q15080ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MAPK14, NCF4More
Letermovirhsa05144Malaria2.43E-026P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Letermovirhsa05146Amoebiasis4.25E-029P01584, P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311IL1B, CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Letermovirhsa05150Staphylococcus aureus infection1.31E-022P0C0L4, P13646C4A, KRT13More
Letermovirhsa05169Epstein-Barr virus infection3.66E-025P01106, Q13547, Q13761, P42224, P07766MYC, HDAC1, RUNX3, STAT1, CD3EMore
Letermovirhsa05202Transcriptional misregulation in cancer6.59E-0315P17844, P14780, P27930, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522DDX5, MMP9, IL1R2, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Letermovirhsa05203Viral carcinogenesis1.29E-037Q13547, Q15283, P12814, P06493, P62807, Q16778, O60814HDAC1, RASA2, ACTN1, CDK1, HIST1H2BC, HIST2H2BE, H2BC12More
Letermovirhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Letermovirhsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Letermovirhsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Letermovirhsa05231Choline metabolism in cancer1.39E-023Q9Y259, P19174, P49619CHKB, PLCG1, DGKGMore
Letermovirhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer9.69E-0412O95267, P19174, P07766, P20963, P09693, P06239, P23458, P42224, O60603, Q04759, Q16539, Q9HC35RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, STAT1, TLR2, PRKCQ, MAPK14, EML4More
Letermovirhsa05321Inflammatory bowel disease1.21E-027O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Letermovirhsa05322Systemic lupus erythematosus2.21E-057P09871, Q93077, P62807, Q16778, O60814, P68431, P12814C1S, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1More
Letermovirhsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Letermovirhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore

Community members of Letermovir (SDC: 3.23)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P20292ALOX5APArachidonate 5NonelipoxygenaseNoneactivating proteinPredicted00.13030.24180.09070.6395
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)