PharmaCoNets of Lesinurad (SPCN: 97.64 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Lesinuradhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Lesinuradhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Lesinuradhsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Lesinuradhsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Lesinuradhsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Lesinuradhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Lesinuradhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Lesinuradhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Lesinuradhsa00620Pyruvate metabolism3.19E-022P40926, P14550MDH2, AKR1A1More
Lesinuradhsa00630Glyoxylate and dicarboxylate metabolism4.29E-032P40925, P15104MDH1, GLULMore
Lesinuradhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Lesinuradhsa00730Thiamine metabolism1.20E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Lesinuradhsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Lesinuradhsa00790Folate biosynthesis1.04E-023Q92820, P05186, P42330GGH, ALPL, AKR1C3More
Lesinuradhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-054Q16772, P78417, P09211, P11712GSTA3, GSTO1, GSTP1, CYP2C9More
Lesinuradhsa00982Drug metabolism - cytochrome P4501.77E-044P11712, Q16772, P09211, P78417CYP2C9, GSTA3, GSTP1, GSTO1More
Lesinuradhsa00983Drug metabolism - other enzymes2.12E-045P04183, P32320, P05164, Q16772, P09211TK1, CDA, MPO, GSTA3, GSTP1More
Lesinuradhsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Lesinuradhsa01523Antifolate resistance2.02E-034P41439, P41440, Q92820, P01375FOLR3, SLC19A1, GGH, TNFMore
Lesinuradhsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Lesinuradhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Lesinuradhsa03008Ribosome biogenesis in eukaryotes1.46E-024Q9NYH9, P78345, Q9BVP2, Q9GZY0UTP6, RPP38, GNL3, NXF2; NXF2BMore
Lesinuradhsa03013RNA transport4.33E-0313P62826, P52298, P61326, Q9UBU9, Q9GZY0, P63279, P68104, Q14152, O75822, P78345, Q9Y6A5, Q14232, Q53GS7RAN, NCBP2, MAGOH, NXF1, NXF2; NXF2B, UBE2I, EEF1A1, EIF3A, EIF3J, RPP38, TACC3, EIF2B1, GLE1More
Lesinuradhsa03015mRNA surveillance pathway9.78E-036O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1More
Lesinuradhsa03020RNA polymerase6.21E-044P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Lesinuradhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Lesinuradhsa03030DNA replication5.00E-021P27694RPA1More
Lesinuradhsa03040Spliceosome6.28E-036Q14562, O43143, O60508, Q07955, Q01130, Q13243DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5More
Lesinuradhsa03050Proteasome4.83E-021P55036PSMD4More
Lesinuradhsa04020Calcium signaling pathway4.83E-024Q08828, P0DP23, P05141, P51828ADCY1, CALM1, SLC25A5, ADCY7More
Lesinuradhsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Lesinuradhsa04024cAMP signaling pathway4.63E-037Q08828, P51828, P42338, P31751, P0DP23, Q13370, Q13009ADCY1, ADCY7, PIK3CB, AKT2, CALM1, PDE3B, TIAM1More
Lesinuradhsa04061Viral protein interaction with cytokine and cytokine receptor3.16E-038Q8NHW4, P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P01375CCL4L2, CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, TNFMore
Lesinuradhsa04064NF-kappa B signaling pathway4.10E-034P01584, P63279, Q8NHW4, Q9NQC7IL1B, UBE2I, CCL4L2, CYLDMore
Lesinuradhsa04070Phosphatidylinositol signaling system1.28E-036P0DP23, P42338, O14986, Q16760, P48426, P27987CALM1, PIK3CB, PIP5K1B, DGKD, PIP4K2A, ITPKBMore
Lesinuradhsa04071Sphingolipid signaling pathway3.08E-025P17252, Q16537, Q9BX95, P04637, P10415PRKCA, PPP2R5E, SGPP1, TP53, BCL2More
Lesinuradhsa04072Phospholipase D signaling pathway2.40E-036P31751, O14986, Q15438, Q08828, P51828, Q16760AKT2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Lesinuradhsa04080Neuroactive ligand-receptor interaction1.40E-028P08311, Q15722, P21453, Q9H228, P43657, P21730, P07550, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY5, C5AR1, ADRB2, ADMMore
Lesinuradhsa04114Oocyte meiosis5.20E-049P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5DMore
Lesinuradhsa04120Ubiquitin mediated proteolysis7.73E-044Q9UBT2, Q13042, Q15751, Q14669SAE2, CDC16, HERC1, TRIP12More
Lesinuradhsa04140Autophagy - animal1.71E-025P31751, Q7L523, O75460, Q96GC9, Q8TEV9AKT2, RRAGA, ERN1, TMEM49, SMCR8More
Lesinuradhsa04145Phagosome3.27E-049P63261, Q15080, P14598, Q13509, P68371, P05164, O60603, P35443, P13765ACTG1, NCF4, NCF1, TUBB3, TUBB2C, MPO, TLR2, THBS4, HLA-DOBMore
Lesinuradhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Lesinuradhsa04211Longevity regulating pathway1.88E-024P31751, Q08828, P51828, P18848AKT2, ADCY1, ADCY7, ATF4More
Lesinuradhsa04213Longevity regulating pathway - multiple species4.07E-035P31751, Q9Y4H2, Q08828, P51828, Q13547AKT2, IRS2, ADCY1, ADCY7, HDAC1More
Lesinuradhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Lesinuradhsa04261Adrenergic signaling in cardiomyocytes4.98E-047Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Lesinuradhsa04270Vascular smooth muscle contraction3.82E-025P24723, Q04759, Q14643, P22694, P35318PRKCH, PRKCQ, ITPR1, PRKACB, ADMMore
Lesinuradhsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Lesinuradhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Lesinuradhsa04371Apelin signaling pathway3.94E-024P31751, Q08828, P51828, P0DP23AKT2, ADCY1, ADCY7, CALM1More
Lesinuradhsa04380Osteoclast differentiation5.27E-0410Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Lesinuradhsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Lesinuradhsa04514Cell adhesion molecules1.22E-022P23229, P30511ITGA6, HLA-FMore
Lesinuradhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Lesinuradhsa04540Gap junction3.53E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Lesinuradhsa04610Complement and coagulation cascades3.19E-021P0C0L4C4AMore
Lesinuradhsa04612Antigen processing and presentation1.19E-027P13765, P26715, P26717, Q07444, Q13241, P01732, P01375HLA-DOB, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, TNFMore
Lesinuradhsa04613Neutrophil extracellular trap formation7.55E-0621P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P62807, P58876, Q16778, O60814, P68431, P14598, Q15080, P21462, P63261, O43315, Q16539PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, ACTG1, AQP9, MAPK14More
Lesinuradhsa04620Toll-like receptor signaling pathway2.54E-033P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Lesinuradhsa04623Cytosolic DNA-sensing pathway2.21E-043P01584, Q9Y535, Q8NHW4IL1B, POLR3H, CCL4L2More
Lesinuradhsa04625C-type lectin receptor signaling pathway1.14E-038Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Lesinuradhsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Lesinuradhsa04640Hematopoietic cell lineage1.40E-028P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Lesinuradhsa04650Natural killer cell mediated cytotoxicity4.93E-0613P16298, P50591, P01375, P06239, O60880, P20963, Q02750, Q13241, P26718, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, TNF, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC3, KLRC1More
Lesinuradhsa04657IL-17 signaling pathway1.36E-025O00463, Q16539, P49841, P14780, P01375TRAF5, MAPK14, GSK3B, MMP9, TNFMore
Lesinuradhsa04658Th1 and Th2 cell differentiation1.71E-049Q04759, P20963, P09693, P06239, Q14765, P23771, Q9UL17, P13765, Q13761PRKCQ, CD247, CD3G, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3More
Lesinuradhsa04659Th17 cell differentiation3.63E-0414P25963, Q04759, P06239, P42224, P14784, P13765, P40189, Q9UL17, P23771, P84022, Q13485, P08238, P09693, P20963NFKBIA, PRKCQ, LCK, STAT1, IL2RB, HLA-DOB, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3G, CD247More
Lesinuradhsa04660T cell receptor signaling pathway1.40E-028P01375, Q04759, Q08881, P20963, P09693, P01732, Q13191, P06239TNF, PRKCQ, ITK, CD247, CD3G, CD8A, CBLB, LCKMore
Lesinuradhsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Lesinuradhsa04666Fc gamma R-mediated phagocytosis8.47E-046P42338, P23528, P49006, P06396, P14598, P17252PIK3CB, CFL1, MARCKSL1, GSN, NCF1, PRKCAMore
Lesinuradhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Lesinuradhsa04713Circadian entrainment4.54E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Lesinuradhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Lesinuradhsa04720Long-term potentiation1.71E-036P16298, P0DP23, P51812, P18848, Q08828, Q02750PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1More
Lesinuradhsa04725Cholinergic synapse1.39E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Lesinuradhsa04728Dopaminergic synapse7.83E-035P31751, P18848, Q13362, Q14738, P0DP23AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Lesinuradhsa04730Long-term depression5.00E-021Q14344GNA13More
Lesinuradhsa04750Inflammatory mediator regulation of TRP channels9.86E-034P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Lesinuradhsa04810Regulation of actin cytoskeleton2.68E-022P23229, Q14344ITGA6, GNA13More
Lesinuradhsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Lesinuradhsa04912GnRH signaling pathway1.39E-024Q08828, P51828, P18848, P0DP23ADCY1, ADCY7, ATF4, CALM1More
Lesinuradhsa04914Progesterone-mediated oocyte maturation2.97E-036Q17RY0, P42338, Q13370, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, HSP90AB1, RPS6KA3, MAP2K1More
Lesinuradhsa04915Estrogen signaling pathway2.13E-025P18848, Q08828, P51828, P31751, P0DP23ATF4, ADCY1, ADCY7, AKT2, CALM1More
Lesinuradhsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Lesinuradhsa04923Regulation of lipolysis in adipocytes5.15E-033Q08828, P51828, P31751ADCY1, ADCY7, AKT2More
Lesinuradhsa04924Renin secretion1.94E-035P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Lesinuradhsa04925Aldosterone synthesis and secretion9.86E-034P18848, Q08828, P51828, P0DP23ATF4, ADCY1, ADCY7, CALM1More
Lesinuradhsa04926Relaxin signaling pathway2.46E-024P31751, P18848, Q08828, P51828AKT2, ATF4, ADCY1, ADCY7More
Lesinuradhsa04927Cortisol synthesis and secretion1.59E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Lesinuradhsa04932Non-alcoholic fatty liver disease7.86E-048P31751, P49841, P18848, O75460, P01584, Q16718, O95298, O14521AKT2, GSK3B, ATF4, ERN1, IL1B, NDUFA5, NDUFC2, SDHDMore
Lesinuradhsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Lesinuradhsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Lesinuradhsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Lesinuradhsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Lesinuradhsa04970Salivary secretion1.59E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Lesinuradhsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Lesinuradhsa04972Pancreatic secretion1.99E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Lesinuradhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Lesinuradhsa04976Bile secretion9.77E-045O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Lesinuradhsa05010Alzheimer disease4.94E-039O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4More
Lesinuradhsa05016Huntington disease2.24E-027O95298, P24928, P30876, P62487, P05141, O75460, P28070NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Lesinuradhsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Lesinuradhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Lesinuradhsa05022Pathways of neurodegeneration - multiple diseases4.63E-0415P49841, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P05141, Q16539, Q00535, P01584, Q08752, P0DP23, P28070GSK3B, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, MAPK14, CDK5, IL1B, PPID, CALM1, PSMB4More
Lesinuradhsa05034Alcoholism2.05E-057Q13547, Q93077, P62807, P58876, Q16778, O60814, P68431HDAC1, HIST1H2AC, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Lesinuradhsa05132Salmonella infection2.05E-0310P25963, Q9UJU2, P63261, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371NFKBIA, LEF1, ACTG1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Lesinuradhsa05133Pertussis2.63E-022P10145, P0C0L4IL8, C4AMore
Lesinuradhsa05140Leishmaniasis4.13E-025P14598, P13765, O60603, P49006, Q15080NCF1, HLA-DOB, TLR2, MARCKSL1, NCF4More
Lesinuradhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Lesinuradhsa05146Amoebiasis5.91E-037P09341, P27930, P01375, P05089, P22694, P12814, P08311CXCL1, IL1R2, TNF, ARG1, PRKACB, ACTN1, CTSGMore
Lesinuradhsa05150Staphylococcus aureus infection1.91E-024Q14532, P59665, P59666, P49913KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Lesinuradhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Lesinuradhsa05163Human cytomegalovirus infection1.79E-0617P31751, P01375, P30511, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, O00463AKT2, TNF, HLA-F, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TRAF5More
Lesinuradhsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Lesinuradhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Lesinuradhsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Lesinuradhsa05168Herpes simplex virus 1 infection1.95E-0314P25963, P42224, Q07955, Q01130, Q13243, P42338, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6NFKBIA, STAT1, SFRS1, SFRS2, SFRS5, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212More
Lesinuradhsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Lesinuradhsa05200Pathways in cancer3.92E-029P42338, P08238, P42224, P43246, P14923, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, MSH2, JUP, GADD45B, CALM1, IL2RB, IL6STMore
Lesinuradhsa05202Transcriptional misregulation in cancer7.73E-0519Q12778, Q15532, P41732, P14780, P27930, P14923, Q15744, Q16548, P11215, Q13489, O15550, P04637, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522FOXO1, SS18, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, ITGAM, BIRC3, UTX, TP53, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Lesinuradhsa05203Viral carcinogenesis2.10E-048Q12933, P42229, Q13547, Q15283, P62807, P58876, Q16778, O60814TRAF2, STAT5A, HDAC1, RASA2, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12More
Lesinuradhsa05204Chemical carcinogenesis1.77E-044Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Lesinuradhsa05205Proteoglycans in cancer2.66E-028Q14643, P63261, P04637, P14780, P17252, O60603, Q13635, P08962ITPR1, ACTG1, TP53, MMP9, PRKCA, TLR2, PTCH1, CD63More
Lesinuradhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Lesinuradhsa05212Pancreatic cancer8.97E-058P42338, P31751, Q15311, P23458, P42224, P84022, Q13485, O75293PIK3CB, AKT2, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45BMore
Lesinuradhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Lesinuradhsa05214Glioma1.72E-023P0DP23, P42338, O75293CALM1, PIK3CB, GADD45BMore
Lesinuradhsa05216Thyroid cancer3.59E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Lesinuradhsa05217Basal cell carcinoma1.46E-024Q13635, Q9UJU2, P04637, P24522PTCH1, LEF1, TP53, GADD45AMore
Lesinuradhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Lesinuradhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Lesinuradhsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Lesinuradhsa05231Choline metabolism in cancer3.38E-023P31751, Q16760, O14986AKT2, DGKD, PIP5K1BMore
Lesinuradhsa05310Asthma1.04E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Lesinuradhsa05321Inflammatory bowel disease4.38E-035P01375, P13765, Q14765, Q9UL17, P23771TNF, HLA-DOB, STAT4, TBX21, GATA3More
Lesinuradhsa05322Systemic lupus erythematosus5.29E-0613O75015, P08246, P08311, P09871, P01375, P13765, Q93077, P62807, P58876, Q16778, O60814, P68431, P12814FCGR3B, ELA2, CTSG, C1S, TNF, HLA-DOB, HIST1H2AC, HIST1H2BC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1More
Lesinuradhsa05323Rheumatoid arthritis3.53E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Lesinuradhsa05332Graft-versus-host disease8.29E-044P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Lesinuradhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Lesinuradhsa05418Fluid shear stress and atherosclerosis3.01E-0515Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P63261, P04637, P10415, P14778, P27930, P0DP23, P08238, Q92974MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, ACTG1, TP53, BCL2, IL1R1, IL1R2, CALM1, HSP90AB1, ARHGEF2More

Community members of Lesinurad (SDC: 5.20)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P27694RPA1Replication protein A 70 kDa DNANonebinding subunitPredicted00.22730.17560.27460.7395
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P14550AKR1A1AldoNoneketo reductase family 1 member A1Predicted10.30560.06210.17370.4508
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P11766ADH5Alcohol dehydrogenase classNone3Predicted00.2650.13970.21460.6265
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q13093PLA2G7PlateletNoneactivating factor acetylhydrolasePredicted00.05050.20960.15580.6001
P11511CYP19A1AromatasePredicted00.815610.15882.5666
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)