PharmaCoNets of Lemborexant (SPCN: 273.15 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Lemborexanthsa00010Glycolysis / Gluconeogenesis1.89E-035P04075, P14550, P11766, P07195, P60174ALDOA, AKR1A1, ADH5, LDHB, TPI1More
Lemborexanthsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Lemborexanthsa00030Pentose phosphate pathway5.38E-125P60891, P51854, P08237, P52209, P37837PRPS1, TKTL1, PFKM, PGD, TALDO1More
Lemborexanthsa00040Pentose and glucuronate interconversions2.20E-032Q9UEF7, O60701KL, UGDHMore
Lemborexanthsa00051Fructose and mannose metabolism2.63E-055P15121, P19367, P08237, P60174, P04075AKR1B1, HK1, PFKM, TPI1, ALDOAMore
Lemborexanthsa00052Galactose metabolism1.02E-066P06280, P08237, O43451, P15121, P19367, Q14376GLA, PFKM, MGAM, AKR1B1, HK1, GALEMore
Lemborexanthsa00062Fatty acid elongation3.94E-021Q9H5J4ELOVL6More
Lemborexanthsa00071Fatty acid degradation2.44E-045P11310, O75521, P00325, P11766, P33121ACADM, ECI2, ADH1B, ADH5, ACSL1More
Lemborexanthsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Lemborexanthsa00140Steroid hormone biosynthesis4.28E-021P22680CYP7A1More
Lemborexanthsa00190Oxidative phosphorylation1.94E-063Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Lemborexanthsa00220Arginine biosynthesis1.23E-093P15104, P05089, P49448GLUL, ARG1, GLUD2More
Lemborexanthsa00230Purine metabolism3.35E-022Q7LG56, P51828RRM2B, ADCY7More
Lemborexanthsa00250Alanine, aspartate and glutamate metabolism3.77E-063Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Lemborexanthsa00270Cysteine and methionine metabolism7.38E-042Q96RQ9, P40926IL4I1, MDH2More
Lemborexanthsa00280Valine, leucine and isoleucine degradation1.93E-046P55809, Q9HCC0, Q96RQ9, P05166, Q02252, P11310OXCT1, MCCC2, IL4I1, PCCB, ALDH6A1, ACADMMore
Lemborexanthsa00310Lysine degradation2.14E-057Q9NVH6, Q96KQ7, Q8NEZ4, Q13029, O15047, Q02809, P51648TMLHE, EHMT2, MLL3, PRDM2, SETD1A, PLOD1, ALDH3A2More
Lemborexanthsa00330Arginine and proline metabolism2.73E-021P17707AMD1More
Lemborexanthsa00380Tryptophan metabolism3.02E-021Q16613AANATMore
Lemborexanthsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Lemborexanthsa00471D-Glutamine and D-glutamate metabolism1.54E-032Q7Z3D6, P49448C14orf159, GLUD2More
Lemborexanthsa00500Starch and sucrose metabolism2.92E-094O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Lemborexanthsa00510N-Glycan biosynthesis1.10E-034O94777, P15907, Q9BVK2, Q9NR34DPM2, ST6GAL1, ALG8, MAN1C1More
Lemborexanthsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Lemborexanthsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Lemborexanthsa00515Mannose type O-glycan biosynthesis2.16E-021O75072FCMDMore
Lemborexanthsa00520Amino sugar and nucleotide sugar metabolism1.75E-063Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Lemborexanthsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Lemborexanthsa00531Glycosaminoglycan degradation3.78E-021P15586GNSMore
Lemborexanthsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Lemborexanthsa00562Inositol phosphate metabolism4.54E-045Q9NRR6, P27987, O14732, P19174, P42338INPP5E, ITPKB, IMPA2, PLCG1, PIK3CBMore
Lemborexanthsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.28E-032O94777, Q14442DPM2, PIGHMore
Lemborexanthsa00564Glycerophospholipid metabolism5.64E-066P48651, Q9Y6K0, P35790, P23743, O14494, Q3LIE5PTDSS1, CEPT1, CHKA, DGKA, PLPP1, ADPRMMore
Lemborexanthsa00590Arachidonic acid metabolism2.48E-033P11712, P09917, P09960CYP2C9, ALOX5, LTA4HMore
Lemborexanthsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Lemborexanthsa00600Sphingolipid metabolism2.65E-033Q9BX95, Q06136, P15289SGPP1, FVT1, ARSAMore
Lemborexanthsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.27E-072P06865, O75752HEXA, B3GALNT1More
Lemborexanthsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Lemborexanthsa00620Pyruvate metabolism9.80E-044P40926, P07195, P14550, P11766MDH2, LDHB, AKR1A1, ADH5More
Lemborexanthsa00630Glyoxylate and dicarboxylate metabolism3.78E-104P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Lemborexanthsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Lemborexanthsa00670One carbon pool by folate1.72E-053O95954, P04818, Q99707FTCD, TYMS, MTRMore
Lemborexanthsa00730Thiamine metabolism1.75E-073Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Lemborexanthsa00740Riboflavin metabolism2.80E-032P30043, P24666BLVRB, ACP1More
Lemborexanthsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Lemborexanthsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Lemborexanthsa00770Pantothenate and CoA biosynthesis2.82E-053O95498, Q6ZQY3, Q9NRN7VNN2, GADL1, AASDHPPTMore
Lemborexanthsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Lemborexanthsa00790Folate biosynthesis1.04E-023Q92820, P05186, P42330GGH, ALPL, AKR1C3More
Lemborexanthsa00830Retinol metabolism3.48E-055P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Lemborexanthsa00860Porphyrin and chlorophyll metabolism7.35E-053P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Lemborexanthsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Lemborexanthsa00910Nitrogen metabolism1.75E-042P15104, P49448GLUL, GLUD2More
Lemborexanthsa00920Sulfur metabolism1.78E-021Q16762TSTMore
Lemborexanthsa00970Aminoacyl-tRNA biosynthesis2.71E-064O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Lemborexanthsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Lemborexanthsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Lemborexanthsa00983Drug metabolism - other enzymes9.89E-085P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Lemborexanthsa01040Biosynthesis of unsaturated fatty acids1.57E-042P22307, Q9H5J4SCP2, ELOVL6More
Lemborexanthsa01100Metabolic pathways4.35E-0881Q9NR34, Q9Y234, P35790, P05089, P21953, Q16772, Q9UJ14, P15144, P30041, P15104, P19367, P42338, Q9Y217, P48426, O14732, P27987, Q96DU7, P22557, Q6ZQY3, P32320, Q08828, Q02153, Q16774, P20839, P00918, P22748, P40926, P10768, P55809, P06280, O94777, Q16875, O43286, O43451, P53004, Q9Y6K0, P05186, P24666, P15121, P08237, Q86XP1, O95861, P21399, Q96RQ9, Q9HCC0, P33121, Q9UHK6, P51854, Q86VZ5, Q96G23, P09917, P48651, Q9BVK2, P15907, P57054, Q14442, Q9UNP4, O96024, Q9H4F1, Q9BX95, Q9BRR6, P37837, P32321, P49448, P50213, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P05166, P14927, P12074, P05496, Q99437, O15239, Q13029, O15047, Q9NVH6MAN1C1, LIPT1, CHKA, ARG1, BCKDHB, GSTA3, GGTL3, ANPEP, PRDX6, GLUL, HK1, PIK3CB, MTMR6, PIP4K2A, IMPA2, ITPKB, ITPKC, ALAS2, GADL1, CDA, ADCY1, GUCY1B3, GUK1, IMPDH1, CA2, CA4, MDH2, ESD, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, BLVRA, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKH, BPNT1, ACO1, IL4I1, MCCC2, ACSL1, AMACR, TKTL1, SGMS1, LASS2, ALOX5, PTDSS1, ALG8, ST6GAL1, PIGP, PIGH, ST3GAL5, B3GALT4, ST6GALNAC4, SGPP1, ADPGK, TALDO1, DCTD, GLUD2, IDH3A, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, PCCB, UQCRB, COX6A1, ATP5G1, ATP6V0B, NDUFA1, PRDM2, SETD1A, TMLHEMore
Lemborexanthsa01200Carbon metabolism3.31E-037P51854, P08237, P52209, P37837, P50213, P21399, P10768TKTL1, PFKM, PGD, TALDO1, IDH3A, ACO1, ESDMore
Lemborexanthsa012102-Oxocarboxylic acid metabolism1.73E-022P21399, P50213ACO1, IDH3AMore
Lemborexanthsa01212Fatty acid metabolism7.91E-044Q9H5J4, P22307, P33121, P11310ELOVL6, SCP2, ACSL1, ACADMMore
Lemborexanthsa01230Biosynthesis of amino acids5.74E-089P08237, P51854, P60891, Q99707, P21399, P50213, P05089, P15104, P37837PFKM, TKTL1, PRPS1, MTR, ACO1, IDH3A, ARG1, GLUL, TALDO1More
Lemborexanthsa01240Biosynthesis of cofactors2.85E-047Q969G6, P13716, P36551, P22557, O60701, P14618, Q9Y234RFK, ALAD, CPOX, ALAS2, UGDH, PKM2, LIPT1More
Lemborexanthsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Lemborexanthsa01522Endocrine resistance1.44E-049P14780, P22694, P04049, Q9UM47, P04637, P42773, P08069, P10415, Q13323MMP9, PRKACB, RAF1, NOTCH3, TP53, CDKN2C, IGF1R, BCL2, BIKMore
Lemborexanthsa01523Antifolate resistance1.50E-065P41440, Q92820, P04818, P01375, P18054SLC19A1, GGH, TYMS, TNF, ALOX12More
Lemborexanthsa01524Platinum drug resistance2.37E-058Q13489, Q14790, P48023, P78417, P40692, P23025, P52701, P31751BIRC3, CASP8, FASLG, GSTO1, MLH1, XPA, MSH6, AKT2More
Lemborexanthsa02010ABC transporters4.48E-021Q8IZY2ABCA7More
Lemborexanthsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Lemborexanthsa03010Ribosome7.89E-1321P26373, P62753, P42677, P25398, P32969, P62917, P62829, P46776, Q9H0U6, Q07020, P62888, P62899, P62910, P18077, P61927, P61513, Q02878, P36578, P27635, P05386, P23396RPL13, RPS6, RPS27, RPS12, RPL9, RPL8, RPL23, RPL27A, MRPL18, RPL18, RPL30, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPL6, RPL4, RPL10, RPLP1, RPS3More
Lemborexanthsa03013RNA transport2.17E-2232P62826, O14980, P52298, Q09161, O14893, P61326, P38919, Q15287, Q9UBU9, Q9H307, P37198, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, Q9H777, P11940, P20042, Q14240, Q9BZI7, P23588, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, RNPS1, NXF1, PNN, NUP62, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, ELAC1, PABPC1, EIF2S2, EIF4A2, UPF3B, EIF4B, TACC3, EIF2B1, FMR1, FXR1More
Lemborexanthsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Lemborexanthsa03020RNA polymerase2.47E-126P30876, P24928, P62487, Q9GZM3, P52435, Q9Y535POLR2B, POLR2A, POLR2G, POLR2J2, POLR2J, POLR3HMore
Lemborexanthsa03022Basal transcription factors3.52E-033O00268, Q5H9L4, Q15544TAF4, TAF7L, TAF11More
Lemborexanthsa03040Spliceosome1.75E-1316Q14562, O43143, O60508, P08579, P26368, O75940, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, SMNDC1, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Lemborexanthsa03050Proteasome2.26E-022P55036, P28074PSMD4, PSMB5More
Lemborexanthsa03060Protein export3.67E-094Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Lemborexanthsa03320PPAR signaling pathway4.93E-034Q6PCB7, O00767, Q9UNU6, Q02318SLC27A1, SCD, CYP8B1, CYP27A1More
Lemborexanthsa03430Mismatch repair4.38E-021P20585MSH3More
Lemborexanthsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Lemborexanthsa03460Fanconi anemia pathway8.90E-043P40692, O60673, Q9UNA4MLH1, REV3L, POLIMore
Lemborexanthsa04010MAPK signaling pathway4.32E-048P04049, Q15283, P21860, P08069, Q9H2K8, Q12933, P01584, O14944RAF1, RASA2, ERBB3, IGF1R, TAOK3, TRAF2, IL1B, EREGMore
Lemborexanthsa04012ErbB signaling pathway3.61E-057Q13153, P16333, Q13191, P19174, P42338, P01106, P04049PAK1, NCK1, CBLB, PLCG1, PIK3CB, MYC, RAF1More
Lemborexanthsa04014Ras signaling pathway5.12E-0515P04049, P31751, P42338, P20827, Q9NRA1, P49767, P08069, Q13009, P17252, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174RAF1, AKT2, PIK3CB, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, PRKCA, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1More
Lemborexanthsa04015Rap1 signaling pathway5.43E-0616P04049, P20827, Q9NRA1, P49767, P08069, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, P42338, P31751, P0DP23, P17252, P19174RAF1, EFNA1, PDGFC, VEGFC, IGF1R, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, PIK3CB, AKT2, CALM1, PRKCA, PLCG1More
Lemborexanthsa04020Calcium signaling pathway2.45E-0817Q96DU7, Q08828, P21796, P45880, Q13557, P17252, P21860, P30679, P19174, P0DP23, P0DP24, P05141, P51828, P20020, P23634, Q9NRA1, P49767ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, PRKCA, ERBB3, GNA15, PLCG1, CALM1, CALM2, SLC25A5, ADCY7, ATP2B1, ATP2B4, PDGFC, VEGFCMore
Lemborexanthsa04022cGMP-PKG signaling pathway1.32E-0712Q02153, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Lemborexanthsa04024cAMP signaling pathway2.01E-059Q08828, P51828, P42338, P31751, P0DP23, P04049, Q13370, Q13009, Q13153ADCY1, ADCY7, PIK3CB, AKT2, CALM1, RAF1, PDE3B, TIAM1, PAK1More
Lemborexanthsa04060Cytokine-cytokine receptor interaction1.60E-0518P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, O75509, P09341, P19875, P80075, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, TNFRSF21, CXCL1, CXCL2, CCL8, CD4, TNFRSF25More
Lemborexanthsa04061Viral protein interaction with cytokine and cytokine receptor2.92E-0611Q8NHW4, P09341, P19875, P25024, P02775, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCL2, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Lemborexanthsa04062Chemokine signaling pathway1.20E-0723P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P14598, P42224, P04049, P25963, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, NCF1, STAT1, RAF1, NFKBIA, PIK3R5More
Lemborexanthsa04064NF-kappa B signaling pathway2.24E-2430P10415, Q13489, P25963, P51617, Q12933, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, P10145, P19784, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF2, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, IL8, CSNK2A2, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Lemborexanthsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Lemborexanthsa04068FoxO signaling pathway4.41E-054P04049, P08069, P48023, Q96BR1RAF1, IGF1R, FASLG, SGK3More
Lemborexanthsa04070Phosphatidylinositol signaling system1.87E-0713P19174, P0DP23, Q14643, P42338, O14986, P23743, P49619, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252PLCG1, CALM1, ITPR1, PIK3CB, PIP5K1B, DGKA, DGKG, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Lemborexanthsa04071Sphingolipid signaling pathway8.10E-1213P04049, P17252, P21453, Q9H228, P01375, Q96G23, Q13362, Q9BX95, Q16539, P10415, Q9UQC2, Q12933, Q02156RAF1, PRKCA, S1PR1, EDG8, TNF, LASS2, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2, TRAF2, PRKCEMore
Lemborexanthsa04072Phospholipase D signaling pathway9.04E-0715P04049, P31751, P42338, Q92529, Q9UQC2, P43657, P25024, P25025, P19174, O14986, Q14344, Q15438, Q08828, P51828, Q16760RAF1, AKT2, PIK3CB, SHC3, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, GNA13, PSCD1, ADCY1, ADCY7, DGKDMore
Lemborexanthsa04080Neuroactive ligand-receptor interaction1.57E-0613P08311, P78334, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, Q16581, P30939, P07550, P35318CTSG, GABRE, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, C3AR1, HTR1F, ADRB2, ADMMore
Lemborexanthsa04110Cell cycle1.19E-0813Q9UBD5, P30260, P06493, O60566, Q14683, O75293, P04637, P49918, P30304, P33981, P42773, P01106, Q13547ORC3, CDC27, CDK1, BUB1B, SMC1A, GADD45B, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Lemborexanthsa04114Oocyte meiosis2.64E-1111Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Lemborexanthsa04115p53 signaling pathway4.19E-036P24522, O15151, Q13315, Q53FA7, O95067, P10415GADD45A, MDM4, ATM, TP53I3, CCNB2, BCL2More
Lemborexanthsa04120Ubiquitin mediated proteolysis8.56E-057Q9UBT2, Q14145, Q13042, Q93034, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, CUL5, UBE2D2, HERC1, TRIP12More
Lemborexanthsa04122Sulfur relay system1.78E-021Q16762TSTMore
Lemborexanthsa04136Autophagy - other4.51E-062O94817, Q9H1Y0ATG12, ATG5More
Lemborexanthsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Lemborexanthsa04140Autophagy - animal1.18E-0515P08069, Q9Y4H2, P42338, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, PIK3CB, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Lemborexanthsa04141Protein processing in endoplasmic reticulum1.13E-0412P18848, Q12933, P30101, Q15436, P60604, Q99941, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9UNL2ATF4, TRAF2, PDIA3, SEC23A, UBE2G2, CREBL1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SSR3More
Lemborexanthsa04142Lysosome1.89E-0613Q99437, P25774, O14773, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916, Q04900ATP6V0B, CTSS, TPP1, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2, CD164More
Lemborexanthsa04144Endocytosis2.52E-0719Q13191, P0DMV8, P11142, Q9H444, O43633, O75351, P62491, P25024, Q96B97, P43250, Q6WKZ4, Q15438, Q8WU79, Q14161, P14784, O95219, O75154, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, CHMP2A, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, RAB11FIP1, PSCD1, SMAP1L, GIT2, IL2RB, SNX4, RAB11FIP3, SNX12, SNX5More
Lemborexanthsa04145Phagosome2.12E-1013O75015, Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Lemborexanthsa04146Peroxisome1.43E-024O00623, P56589, Q9UKG9, P33121PEX12, PEX3, CROT, ACSL1More
Lemborexanthsa04150mTOR signaling pathway1.32E-035P08069, P04049, Q02750, Q9NQL2, P51812IGF1R, RAF1, MAP2K1, RRAGD, RPS6KA3More
Lemborexanthsa04151PI3K-Akt signaling pathway5.47E-0838P62753, P42338, P21860, P43657, P25116, O43521, P04637, P27348, P20827, P49767, Q13362, P07900, P08238, Q8WYR1, P62873, P63218, P50151, P61952, P16144, O15335, P02452, P24821, Q16363, Q13751, P22105, O60603, P14784, P23458, P01568, Q99941, P18848, P10415, P17252, Q96BR1, O00141, Q6ZUJ8, P30281, P56279RPS6, PIK3CB, ERBB3, P2RY5, F2R, BCL2L11, TP53, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AA1, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, GNG11, ITGB4, CHAD, COL1A1, TNC, LAMA4, LAMB3, TNXB, TLR2, IL2RB, JAK1, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGK3, SGK, PIK3AP1, CCND3, TCL1AMore
Lemborexanthsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Lemborexanthsa04210Apoptosis5.85E-0515Q13315, P10415, Q13489, O76075, P25963, Q14790, P01375, P48023, Q9NR28, P24522, Q16548, Q13077, Q14643, P42575, P04049ATM, BCL2, BIRC3, DFFB, NFKBIA, CASP8, TNF, FASLG, DIABLO, GADD45A, BCL2A1, TRAF1, ITPR1, CASP2, RAF1More
Lemborexanthsa04211Longevity regulating pathway1.55E-059Q12778, P31751, P08069, Q08828, P51828, P18848, Q9UEF7, Q96RR4, Q96KQ7FOXO1, AKT2, IGF1R, ADCY1, ADCY7, ATF4, KL, CAMKK2, EHMT2More
Lemborexanthsa04213Longevity regulating pathway - multiple species1.70E-089P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Lemborexanthsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Lemborexanthsa04217Necroptosis9.24E-1626P01375, Q12933, P01568, P23458, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, P10415, Q13557, Q9H444, O43633, O75351, P45880, Q08752TNF, TRAF2, IFNA21, JAK1, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CAMK2D, CHMP4B, CHMP2A, VPS4B, VDAC2, PPIDMore
Lemborexanthsa04218Cellular senescence3.45E-0511P01106, P31751, P04049, P30281, O75293, P30304, P06493, P0DP23, P01889, P10321, P12236MYC, AKT2, RAF1, CCND3, GADD45B, CDC25A, CDK1, CALM1, HLA-B, HLA-C, SLC25A6More
Lemborexanthsa04260Cardiac muscle contraction4.41E-035P09493, P67936, P13073, P12074, P14927TPM1, TPM4, COX4I1, COX6A1, UQCRBMore
Lemborexanthsa04261Adrenergic signaling in cardiomyocytes6.80E-0915P09493, P67936, Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, P0DP24, Q13557, P17252, P10415, P23634TPM1, TPM4, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CALM2, CAMK2D, PRKCA, BCL2, ATP2B4More
Lemborexanthsa04270Vascular smooth muscle contraction3.12E-0711P24723, Q04759, Q14643, P0DP23, P04049, Q08828, P51828, P22694, P35579, P35749, P35318PRKCH, PRKCQ, ITPR1, CALM1, RAF1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADMMore
Lemborexanthsa04310Wnt signaling pathway2.28E-045P30279, Q13485, O43318, P17612, P67870CCND2, SMAD4, MAP3K7, PRKACA, CSNK2BMore
Lemborexanthsa04330Notch signaling pathway2.90E-076Q92542, P49768, Q92830, P78504, P46531, Q9UM47NCSTN, PSEN1, KAT2A, JAG1, NOTCH1, NOTCH3More
Lemborexanthsa04340Hedgehog signaling pathway2.85E-055P49841, P17612, P22694, Q13635, P10415GSK3B, PRKACA, PRKACB, PTCH1, BCL2More
Lemborexanthsa04360Axon guidance8.72E-0714P16298, Q05397, P16333, P20827, O95631, P17252, Q13873, P42338, P07332, P23528, P04049, P19174, O14639, P24844PPP3CB, PTK2, NCK1, EFNA1, NTN1, PRKCA, BMPR2, PIK3CB, FES, CFL1, RAF1, PLCG1, ABLIM1, MYL9More
Lemborexanthsa04370VEGF signaling pathway5.06E-157P19174, P16298, P31751, P42338, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PTK2, MAP2K1, RAF1More
Lemborexanthsa04371Apelin signaling pathway6.36E-0616P62873, P63218, P50151, P61952, Q8WYR1, P31751, P04049, Q08828, P51828, Q14814, Q14344, Q13485, P84022, P62753, P0DP23, P0DP24GNB1, GNG5, GNG10, GNG11, PIK3R5, AKT2, RAF1, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, RPS6, CALM1, CALM2More
Lemborexanthsa04380Osteoclast differentiation2.23E-0914Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Lemborexanthsa04390Hippo signaling pathway2.24E-067O95835, P84022, Q13485, P04628, Q9UJU2, O43623, Q13489LATS1, SMAD3, SMAD4, WNT1, LEF1, SNAI2, BIRC3More
Lemborexanthsa04392Hippo signaling pathway - multiple species2.11E-053O95835, Q13153, Q6V0I7LATS1, PAK1, FAT4More
Lemborexanthsa04510Focal adhesion1.63E-035Q15942, P51636, P30281, P04049, P08069ZYX, CAV2, CCND3, RAF1, IGF1RMore
Lemborexanthsa04512ECM-receptor interaction2.77E-056P02452, P24821, P07359, P26012, P08514, P16070COL1A1, TNC, GP1BA, ITGB8, ITGA2B, CD44More
Lemborexanthsa04514Cell adhesion molecules2.37E-022P16109, O00501SELP, CLDN5More
Lemborexanthsa04520Adherens junction1.81E-033Q13485, O43318, P08069SMAD4, MAP3K7, IGF1RMore
Lemborexanthsa04530Tight junction2.74E-046Q8TEU7, P16989, P56750, O00501, Q14247, P24844RAPGEF6, CSDA, CLDN17, CLDN5, CTTN, MYL9More
Lemborexanthsa04540Gap junction4.06E-066P17252, Q13509, P68371, P04049, Q9NRA1, Q14643PRKCA, TUBB3, TUBB2C, RAF1, PDGFC, ITPR1More
Lemborexanthsa04550Signaling pathways regulating pluripotency of stem cells1.61E-035Q13873, P04049, Q02750, P08069, Q86SE9BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Lemborexanthsa04610Complement and coagulation cascades2.35E-136P09871, P00734, P0C0L4, P20023, P05107, P21730C1S, F2, C4A, CR2, ITGB2, C5AR1More
Lemborexanthsa04611Platelet activation2.65E-056Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Lemborexanthsa04612Antigen processing and presentation6.50E-1313P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P30101, P30511, P11142, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, PDIA3, HLA-F, HSPA8, TNFMore
Lemborexanthsa04613Neutrophil extracellular trap formation4.38E-1431P19174, P17252, P04049, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q99878, Q93077, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PLCG1, PRKCA, RAF1, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Lemborexanthsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Lemborexanthsa04620Toll-like receptor signaling pathway3.00E-065Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Lemborexanthsa04621NOD-like receptor signaling pathway1.45E-0822P01584, P07900, Q16539, Q14643, P23458, P52630, P01568, P45880, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, P29728, Q05823, P01375, P09341, P49913, P12838IL1B, HSP90AA1, MAPK14, ITPR1, JAK1, STAT2, IFNA21, VDAC2, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA4More
Lemborexanthsa04622RIG-I-like receptor signaling pathway4.69E-105P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Lemborexanthsa04623Cytosolic DNA-sensing pathway1.43E-136P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2More
Lemborexanthsa04625C-type lectin receptor signaling pathway3.89E-1014Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P52630, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, STAT2, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Lemborexanthsa04630JAK-STAT signaling pathway1.01E-048P01106, P31751, P42224, P23458, P14784, P16871, Q13651, P04049MYC, AKT2, STAT1, JAK1, IL2RB, IL7R, IL10RA, RAF1More
Lemborexanthsa04640Hematopoietic cell lineage2.74E-1220P13612, P07359, P08514, P21926, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, GP1BA, ITGA2B, CD9, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Lemborexanthsa04650Natural killer cell mediated cytotoxicity1.15E-2519P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Lemborexanthsa04657IL-17 signaling pathway1.20E-1115P25963, P07900, P08238, O00463, Q12933, Q07955, Q16539, P49841, P09341, P14780, P04141, P80188, P01375, P06702, P01584NFKBIA, HSP90AA1, HSP90AB1, TRAF5, TRAF2, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, CSF2, LCN2, TNF, S100A9, IL1BMore
Lemborexanthsa04658Th1 and Th2 cell differentiation1.12E-3618P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, P23458, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, JAK1, RUNX3More
Lemborexanthsa04659Th17 cell differentiation1.27E-2822P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Lemborexanthsa04660T cell receptor signaling pathway1.02E-2823P01375, P04141, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, Q13153, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P29350, P04049, Q16539, P49841TNF, CSF2, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, PAK1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, PTPN6, RAF1, MAPK14, GSK3BMore
Lemborexanthsa04662B cell receptor signaling pathway4.10E-1313P31751, P42338, P20023, P60033, P13164, P16298, Q8WV28, P07948, P11912, P21854, Q8N149, Q02750, P04049AKT2, PIK3CB, CR2, CD81, IFITM1, PPP3CB, BLNK, LYN, CD79A, CD72, LILRA2, MAP2K1, RAF1More
Lemborexanthsa04664Fc epsilon RI signaling pathway1.04E-0810P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917, P20292TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5, ALOX5APMore
Lemborexanthsa04666Fc gamma R-mediated phagocytosis5.61E-049P08637, O75015, P42338, P04049, P23528, P06396, O14494, P14598, P17252FCGR3A, FCGR3B, PIK3CB, RAF1, CFL1, GSN, PLPP1, NCF1, PRKCAMore
Lemborexanthsa04668TNF signaling pathway2.84E-0714P01375, Q12933, O00463, Q13489, Q16539, P25963, Q99941, P18848, P01584, P20749, Q13077, P14780, P20333, O95429TNF, TRAF2, TRAF5, BIRC3, MAPK14, NFKBIA, CREBL1, ATF4, IL1B, BCL3, TRAF1, MMP9, TNFRSF1B, BAG4More
Lemborexanthsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Lemborexanthsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Lemborexanthsa04710Circadian rhythm2.11E-031O15516CLOCKMore
Lemborexanthsa04713Circadian entrainment3.00E-0911P0DP23, P0DP24, Q13557, Q02153, P17252, P62873, P61952, Q14643, Q08828, P51828, O15055CALM1, CALM2, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG11, ITPR1, ADCY1, ADCY7, PER2More
Lemborexanthsa04714Thermogenesis4.42E-024Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Lemborexanthsa04720Long-term potentiation4.83E-1212P17252, Q13557, P16298, P0DP23, P0DP24, Q15418, P51812, P18848, Q08828, Q02750, P04049, Q14643PRKCA, CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1, ITPR1More
Lemborexanthsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Lemborexanthsa04722Neurotrophin signaling pathway1.76E-0610Q05655, P31751, P04049, P49841, O43524, P48023, P52566, P51617, P10415, P0DP23PRKCD, AKT2, RAF1, GSK3B, FOXO3, FASLG, ARHGDIB, IRAK1, BCL2, CALM1More
Lemborexanthsa04723Retrograde endocannabinoid signaling9.30E-059Q14643, P17252, P62873, P61952, Q08828, P22694, Q16539, O15239, Q16718ITPR1, PRKCA, GNB1, GNG11, ADCY1, PRKACB, MAPK14, NDUFA1, NDUFA5More
Lemborexanthsa04724Glutamatergic synapse2.84E-057O15399, Q08828, P62873, P63218, P50151, P61952, P15104GRIN2D, ADCY1, GNB1, GNG5, GNG10, GNG11, GLULMore
Lemborexanthsa04725Cholinergic synapse3.22E-0713Q08828, P51828, Q14643, P17252, P62873, P63218, P50151, P61952, P18848, Q13557, P42338, P31751, P10415ADCY1, ADCY7, ITPR1, PRKCA, GNB1, GNG5, GNG10, GNG11, ATF4, CAMK2D, PIK3CB, AKT2, BCL2More
Lemborexanthsa04726Serotonergic synapse1.33E-021P04049RAF1More
Lemborexanthsa04727GABAergic synapse6.02E-089Q08828, P51828, P62873, P63218, P50151, P61952, P15104, P46459, Q15111ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, GLUL, NSF, PLCL1More
Lemborexanthsa04728Dopaminergic synapse1.32E-0918Q14643, P17252, P62873, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP23, P0DP24, O15516, P48058ITPR1, PRKCA, GNB1, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM1, CALM2, CLOCK, GRIA4More
Lemborexanthsa04730Long-term depression5.03E-053Q14344, P08069, P04049GNA13, IGF1R, RAF1More
Lemborexanthsa04740Olfactory transduction5.99E-065P62873, Q9H255, Q13557, P0DP23, P0DP24GNB1, OR51E2, CAMK2D, CALM1, CALM2More
Lemborexanthsa04742Taste transduction2.43E-052P30939, P17612HTR1F, PRKACAMore
Lemborexanthsa04744Phototransduction2.15E-103P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Lemborexanthsa04750Inflammatory mediator regulation of TRP channels2.04E-1214P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Lemborexanthsa04810Regulation of actin cytoskeleton1.78E-026Q13009, P04049, P11215, P16144, P60709, P01042TIAM1, RAF1, ITGAM, ITGB4, ACTB, KNG1More
Lemborexanthsa04910Insulin signaling pathway2.43E-056P0DP23, P22694, P06737, P04049, P31751, P49841CALM1, PRKACB, PYGL, RAF1, AKT2, GSK3BMore
Lemborexanthsa04911Insulin secretion6.54E-085Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Lemborexanthsa04912GnRH signaling pathway2.16E-0812P17252, Q08828, P51828, P18848, Q16539, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694, P04049, P45985PRKCA, ADCY1, ADCY7, ATF4, MAPK14, MAP3K4, ITPR1, CALM1, CALM2, PRKACB, RAF1, MAP2K4More
Lemborexanthsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Lemborexanthsa04914Progesterone-mediated oocyte maturation1.97E-109P08069, Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750, P04049IGF1R, CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Lemborexanthsa04915Estrogen signaling pathway8.54E-1012P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, P0DP24, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, CALM2, NCOA1More
Lemborexanthsa04916Melanogenesis7.31E-044P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Lemborexanthsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Lemborexanthsa04918Thyroid hormone synthesis2.47E-045Q08828, Q99941, P18848, P02768, P05543ADCY1, CREBL1, ATF4, ALB, SERPINA7More
Lemborexanthsa04919Thyroid hormone signaling pathway3.02E-0611P49841, P19174, P04049, P42224, P22694, P60709, Q13547, O60244, Q9NVC6, Q9UM47, P01106GSK3B, PLCG1, RAF1, STAT1, PRKACB, ACTB, HDAC1, MED14, MED17, NOTCH3, MYCMore
Lemborexanthsa04920Adipocytokine signaling pathway1.22E-025P25963, P33121, Q04759, P31751, P01375NFKBIA, ACSL1, PRKCQ, AKT2, TNFMore
Lemborexanthsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Lemborexanthsa04922Glucagon signaling pathway3.10E-047P14618, P06737, Q12778, P31751, Q13370, P0DP23, Q14643PKM2, PYGL, FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Lemborexanthsa04923Regulation of lipolysis in adipocytes4.29E-077Q08828, P51828, P07550, P06213, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, INSR, PIK3CB, IRS2, AKT2More
Lemborexanthsa04924Renin secretion7.68E-085P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Lemborexanthsa04925Aldosterone synthesis and secretion1.79E-088Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, CAMK2D, ATP2B4More
Lemborexanthsa04926Relaxin signaling pathway1.62E-0714P31751, P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P49767, Q08828, P51828, P04049, P30679, P49407AKT2, PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, GNA15, ARRB1More
Lemborexanthsa04927Cortisol synthesis and secretion2.32E-054Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Lemborexanthsa04928Parathyroid hormone synthesis, secretion and action1.85E-026Q14643, P22694, P23771, P04049, P17252, P10415ITPR1, PRKACB, GATA3, RAF1, PRKCA, BCL2More
Lemborexanthsa04929GnRH secretion6.93E-064P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Lemborexanthsa04930Type II diabetes mellitus6.29E-053P06213, Q05655, Q02156INSR, PRKCD, PRKCEMore
Lemborexanthsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Lemborexanthsa04932Non-alcoholic fatty liver disease4.44E-1415P31751, P01375, P49841, Q14790, O43521, P18848, P48023, O75460, Q12933, P01584, P13073, P12074, O15239, O95298, P19404AKT2, TNF, GSK3B, CASP8, BCL2L11, ATF4, FASLG, ERN1, TRAF2, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2, NDUFV2More
Lemborexanthsa04933AGE-RAGE signaling pathway in diabetic complications4.38E-069P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Lemborexanthsa04934Cushing syndrome9.97E-096Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Lemborexanthsa04935Growth hormone synthesis, secretion and action5.87E-046Q08828, P51828, P04049, P18848, P31751, P45985ADCY1, ADCY7, RAF1, ATF4, AKT2, MAP2K4More
Lemborexanthsa04940Type I diabetes mellitus5.13E-065P10747, P48023, P13765, P30511, P01375CD28, FASLG, HLA-DOB, HLA-F, TNFMore
Lemborexanthsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Lemborexanthsa04960Aldosterone-regulated sodium reabsorption8.56E-043O00141, P06213, P48048SGK, INSR, KCNJ1More
Lemborexanthsa04962Vasopressin-regulated water reabsorption2.95E-043P52566, P62491, P46459ARHGDIB, RAB11A, NSFMore
Lemborexanthsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Lemborexanthsa04966Collecting duct acid secretion1.95E-033Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Lemborexanthsa04970Salivary secretion4.02E-1011P07550, Q08828, P51828, P22694, Q14643, P23634, P17252, P0DP24, P0DP23, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM2, CALM1, GUCY1B3, CAMPMore
Lemborexanthsa04971Gastric acid secretion3.36E-076Q08828, P51828, P15311, P0DP24, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM2, CALM1, CAMK2DMore
Lemborexanthsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Lemborexanthsa04974Protein digestion and absorption1.22E-032Q7Z2H8, P02452SLC36A1, COL1A1More
Lemborexanthsa04975Fat digestion and absorption1.13E-061O14494PLPP1More
Lemborexanthsa04976Bile secretion1.10E-055Q08828, P51828, P22694, P08183, Q14032ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Lemborexanthsa04979Cholesterol metabolism1.37E-023P38571, P61916, P45880LIPA, NPC2, VDAC2More
Lemborexanthsa05010Alzheimer disease7.59E-1126P49768, Q92542, O15239, Q16718, O95298, P19404, O14521, P05496, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P01584, Q12933, P18848, Q13509, P68371, O15169, P67870, P31751, P05141, Q08752, P28070, P43686PSEN1, NCSTN, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, IL1B, TRAF2, ATF4, TUBB3, TUBB2C, AXIN1, CSNK2B, AKT2, SLC25A5, PPID, PSMB4, PSMC4More
Lemborexanthsa05012Parkinson disease8.86E-0721P62987, O15239, Q16718, O95298, O14521, P13073, P12074, P05496, P05141, P12236, O75460, P18848, P28070, P43686, Q14643, P19174, P0DP23, P0DP24, Q13557, Q13509, P68371UBA52, NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, COX6A1, ATP5G1, SLC25A5, SLC25A6, ERN1, ATF4, PSMB4, PSMC4, ITPR1, PLCG1, CALM1, CALM2, CAMK2D, TUBB3, TUBB2CMore
Lemborexanthsa05014Amyotrophic lateral sclerosis3.59E-0311O15239, P19404, P12074, P05496, O75460, Q12933, P28070, P43686, Q8TEV9, P37198, P35658NDUFA1, NDUFV2, COX6A1, ATP5G1, ERN1, TRAF2, PSMB4, PSMC4, SMCR8, NUP62, NUP214More
Lemborexanthsa05016Huntington disease8.53E-0915O95298, P19404, P13073, P12074, Q9GZM3, P24928, P30876, P62487, P52435, P05141, P45880, Q9NYC9, O75460, P28070, O00232NDUFC2, NDUFV2, COX4I1, COX6A1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, VDAC2, DNAH9, ERN1, PSMB4, PSMD12More
Lemborexanthsa05017Spinocerebellar ataxia1.13E-0410Q92915, O75460, Q8TB72, O15399, P42338, P31751, P28070, P28074, P05141, P21796FGF14, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, PSMB4, PSMB5, SLC25A5, VDAC1More
Lemborexanthsa05020Prion disease1.15E-0723P01584, P46531, P0DMV8, P11142, O15239, Q16718, O95298, O14521, P05496, P13073, P12074, Q14643, P18848, P05141, P12236, P28070, P43686, Q13509, P68371, P67870, Q99941, P14598, Q15080IL1B, NOTCH1, HSPA1A, HSPA8, NDUFA1, NDUFA5, NDUFC2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, TUBB3, TUBB2C, CSNK2B, CREBL1, NCF1, NCF4More
Lemborexanthsa05022Pathways of neurodegeneration - multiple diseases5.83E-1236Q14643, Q13509, P68371, P67870, P10415, O15239, Q16718, O95298, P19404, O14521, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, Q12933, Q13561, P19174, P05141, P45880, P17252, Q15078, Q00535, O15169, P01584, P49768, Q08752, O15020, P0DP23, P0DP24, Q13557, P62987, P28070, P43686ITPR1, TUBB3, TUBB2C, CSNK2B, BCL2, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, TRAF2, DCTN2, PLCG1, SLC25A5, VDAC2, PRKCA, CDK5R1, CDK5, AXIN1, IL1B, PSEN1, PPID, SPTBN2, CALM1, CALM2, CAMK2D, UBA52, PSMB4, PSMC4More
Lemborexanthsa05030Cocaine addiction5.99E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Lemborexanthsa05031Amphetamine addiction4.45E-055P0DP24, P0DP23, Q13557, Q99941, P18848CALM2, CALM1, CAMK2D, CREBL1, ATF4More
Lemborexanthsa05032Morphine addiction5.68E-032P78334, P32298GABRE, GRK4More
Lemborexanthsa05033Nicotine addiction4.01E-021P78334GABREMore
Lemborexanthsa05034Alcoholism7.05E-0715Q99941, P18848, Q13547, P0DP24, Q96RR4, P62873, P61952, P04049, P0C0S5, Q93077, P62807, Q16778, O60814, P84243, P68431CREBL1, ATF4, HDAC1, CALM2, CAMKK2, GNB1, GNG11, RAF1, H2AFZ, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Lemborexanthsa05100Bacterial invasion of epithelial cells2.23E-044Q14141, Q05397, Q92529, Q96JJ3SEPT6, PTK2, SHC3, ELMO2More
Lemborexanthsa05110Vibrio cholerae infection3.23E-055Q13488, Q99437, P17252, P19174, P17612TCIRG1, ATP6V0B, PRKCA, PLCG1, PRKACAMore
Lemborexanthsa05120Epithelial cell signaling in Helicobacter pylori infection2.10E-1210Q16539, Q99437, Q13153, P09341, P19875, P10145, P19174, P25024, P25025, P41240MAPK14, ATP6V0B, PAK1, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2, CSKMore
Lemborexanthsa05130Pathogenic Escherichia coli infection2.77E-039P16333, Q13509, P60709, P25963, P04406, P29350, Q15438, P35579, P55061NCK1, TUBB3, ACTB, NFKBIA, GAPDH, PTPN6, PSCD1, MYH9, TEGTMore
Lemborexanthsa05131Shigellosis9.80E-0724P01375, P25963, Q12933, O00463, Q13546, P68431, Q05655, Q02156, Q04759, Q9UDY8, Q9NQL2, Q9H1Y0, P0CG47, Q14141, Q14247, Q96JJ3, Q05397, Q14643, Q12778, Q13315, P10415, Q08752, Q96A32, P07737TNF, NFKBIA, TRAF2, TRAF5, RIPK1, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCE, PRKCQ, MALT1, RRAGD, ATG5, UBB, SEPT6, CTTN, ELMO2, PTK2, ITPR1, FOXO1, ATM, BCL2, PPID, MYLPF, PFN1More
Lemborexanthsa05132Salmonella infection1.87E-1323P51617, P25963, P01375, P08238, P04049, Q9UJU2, P01106, P84095, P60709, Q13546, Q13489, P10415, P04406, O75369, P07737, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371, P49754IRAK1, NFKBIA, TNF, HSP90AB1, RAF1, LEF1, MYC, RHOG, ACTB, RIPK1, BIRC3, BCL2, GAPDH, FLNB, PFN1, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C, VPS41More
Lemborexanthsa05133Pertussis2.15E-094P05107, P0DP23, P10145, P0C0L4ITGB2, CALM1, IL8, C4AMore
Lemborexanthsa05134Legionellosis1.05E-099P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Lemborexanthsa05135Yersinia infection1.86E-048Q05397, P51812, P06239, P19174, Q02750, P42338, Q96JJ3, P01732PTK2, RPS6KA3, LCK, PLCG1, MAP2K1, PIK3CB, ELMO2, CD8AMore
Lemborexanthsa05140Leishmaniasis2.17E-1416P13612, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Lemborexanthsa05142Chagas disease2.70E-022P48023, Q14790FASLG, CASP8More
Lemborexanthsa05143African trypanosomiasis8.44E-074P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Lemborexanthsa05144Malaria8.55E-1010P60033, P69905, P68871, O60603, P01375, P05107, P35443, P01584, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL1B, IL8, KLRK1More
Lemborexanthsa05145Toxoplasmosis3.52E-0511P51617, P25963, P01375, P10415, Q13489, P42224, P28068, P13765, Q16787, O60603, P29965IRAK1, NFKBIA, TNF, BCL2, BIRC3, STAT1, HLA-DMB, HLA-DOB, LAMA3, TLR2, CD40LGMore
Lemborexanthsa05146Amoebiasis2.39E-1913P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Lemborexanthsa05150Staphylococcus aureus infection1.78E-1016P09871, P0C0L4, P21730, P21462, O75015, P31995, P13765, Q16581, P13646, Q14532, P05107, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, FCGR2C, HLA-DOB, C3AR1, KRT13, KRT32, ITGB2, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Lemborexanthsa05152Tuberculosis3.84E-0918P04049, Q13488, Q99437, P0DP23, O75015, P42224, P48382, O60603, P01375, P31751, P10415, P13765, P25774, P01568, P49913, Q9UDY8, Q16539, P51617RAF1, TCIRG1, ATP6V0B, CALM1, FCGR3B, STAT1, RFX5, TLR2, TNF, AKT2, BCL2, HLA-DOB, CTSS, IFNA21, CAMP, MALT1, MAPK14, IRAK1More
Lemborexanthsa05160Hepatitis C8.08E-0812Q13546, P01568, P52630, P60033, O00501, P29728, Q9NZJ5, P04049, P49841, P01375, P48023, P01106RIPK1, IFNA21, STAT2, CD81, CLDN5, OAS2, EIF2AK3, RAF1, GSK3B, TNF, FASLG, MYCMore
Lemborexanthsa05161Hepatitis B2.46E-0514P17252, P04049, P14780, Q99941, P18848, P25963, Q13485, P01375, P10415, P27348, P84022, P51617, O60603, Q14765PRKCA, RAF1, MMP9, CREBL1, ATF4, NFKBIA, SMAD4, TNF, BCL2, YWHAQ, SMAD3, IRAK1, TLR2, STAT4More
Lemborexanthsa05162Measles5.20E-046P23458, P31751, P0DMV8, P01584, P67870, Q9NP90JAK1, AKT2, HSPA1A, IL1B, CSNK2B, RAB9BMore
Lemborexanthsa05163Human cytomegalovirus infection1.28E-1024P31751, P04049, P01375, P62873, P50151, P61952, Q14643, P0DP23, P0DP24, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P61769AKT2, RAF1, TNF, GNB1, GNG10, GNG11, ITPR1, CALM1, CALM2, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, B2MMore
Lemborexanthsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Lemborexanthsa05165Human papillomavirus infection4.80E-0723P49841, P16144, P02452, P24821, Q16787, Q16363, P01375, Q05086, P30281, Q9UM47, P01568, P52630, P42224, P01889, P10321, P30511, Q13488, Q99437, Q02930, Q13362, Q12778, P04628, Q13315GSK3B, ITGB4, COL1A1, TNC, LAMA3, LAMA4, TNF, UBE3A, CCND3, NOTCH3, IFNA21, STAT2, STAT1, HLA-B, HLA-C, HLA-F, TCIRG1, ATP6V0B, CREB5, PPP2R5C, FOXO1, WNT1, ATMMore
Lemborexanthsa05166Human T-cell leukemia virus 1 infection5.15E-0310P23458, P05141, P62826, Q08828, P51828, P18848, Q02930, P31751, P28068, Q13315JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, CREB5, AKT2, HLA-DMB, ATMMore
Lemborexanthsa05167Kaposi sarcoma-associated herpesvirus infection1.32E-0717P01568, P31751, P42224, P25963, P40189, P62873, P62879, P19174, P16298, Q14643, P04049, Q02750, P01106, P04141, P0DP23, P0CG47, Q9UJU2IFNA21, AKT2, STAT1, NFKBIA, IL6ST, GNB1, GNB2, PLCG1, PPP3CB, ITPR1, RAF1, MAP2K1, MYC, CSF2, CALM1, UBB, LEF1More
Lemborexanthsa05168Herpes simplex virus 1 infection4.15E-0623O00463, O60603, P25963, P01568, Q05823, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q16629, P42338, Q9Y2A4, Q13398, P51522, Q9NR11, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415TRAF5, TLR2, NFKBIA, IFNA21, RNASEL, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, SFRS7, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF302, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Lemborexanthsa05169Epstein-Barr virus infection1.72E-0617P13765, P01106, Q13547, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, P42224, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, STAT1, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Lemborexanthsa05170Human immunodeficiency virus 1 infection7.79E-1223P31751, P04049, Q02750, P62873, P62879, P16298, P0DP23, P01375, Q05397, P17252, O00463, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5, P20333AKT2, RAF1, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, TNF, PTK2, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Lemborexanthsa05171Coronavirus disease - COVID-191.20E-1028P01584, P25963, P42224, P01568, P23396, P62753, P25398, P42677, P36578, Q02878, P62917, P32969, P27635, P26373, Q07020, P62888, P46776, P62899, P62910, P18077, P61927, P61513, P05386, P62829, P40189, P04141, P19174, P17252IL1B, NFKBIA, STAT1, IFNA21, RPS3, RPS6, RPS12, RPS27, RPL4, RPL6, RPL8, RPL9, RPL10, RPL13, RPL18, RPL30, RPL27A, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPLP1, RPL23, IL6ST, CSF2, PLCG1, PRKCAMore
Lemborexanthsa05200Pathways in cancer6.93E-1040Q13751, P42338, P08238, P42224, P25963, P19174, P01106, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, P52701, Q13547, P14923, P30279, P30281, P10415, Q13489, Q13077, P49767, P14921, Q12778, P31751, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, Q9UM47, P78417, O75293, P0DP23, P01568, P14784, P40189, P01042LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, MSH6, HDAC1, JUP, CCND2, CCND3, BCL2, BIRC3, TRAF1, VEGFC, ETS1, FOXO1, AKT2, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST, KNG1More
Lemborexanthsa05202Transcriptional misregulation in cancer3.96E-1624Q12778, Q15532, Q13315, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Lemborexanthsa05203Viral carcinogenesis8.79E-0615Q12933, Q99941, P18848, P30281, P27348, Q13547, Q15283, P06396, P12814, P01889, P10321, P06493, P62807, Q16778, O60814TRAF2, CREBL1, ATF4, CCND3, YWHAQ, HDAC1, RASA2, GSN, ACTN1, HLA-B, HLA-C, CDK1, HIST1H2BC, HIST2H2BE, H2BC12More
Lemborexanthsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Lemborexanthsa05205Proteoglycans in cancer6.79E-0510Q13009, Q12955, O75369, P60709, P04049, P01106, P08069, P19174, P29350, P08962TIAM1, ANK3, FLNB, ACTB, RAF1, MYC, IGF1R, PLCG1, PTPN6, CD63More
Lemborexanthsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Lemborexanthsa05210Colorectal cancer8.05E-0611Q9UKG1, P84022, Q13485, P43246, P04049, P01106, P10415, P52701, P20585, P37173, O75293APPL1, SMAD3, SMAD4, MSH2, RAF1, MYC, BCL2, MSH6, MSH3, TGFBR2, GADD45BMore
Lemborexanthsa05211Renal cell carcinoma5.09E-053Q13153, P31751, P04049PAK1, AKT2, RAF1More
Lemborexanthsa05212Pancreatic cancer7.75E-079P42338, P31751, P04049, Q15311, P23458, P42224, P84022, Q13485, O75293PIK3CB, AKT2, RAF1, RALBP1, JAK1, STAT1, SMAD3, SMAD4, GADD45BMore
Lemborexanthsa05213Endometrial cancer4.41E-044O15169, P31751, Q02750, P04049AXIN1, AKT2, MAP2K1, RAF1More
Lemborexanthsa05214Glioma2.26E-088P08069, P0DP23, P17252, P04049, P42338, P31751, P19174, O75293IGF1R, CALM1, PRKCA, RAF1, PIK3CB, AKT2, PLCG1, GADD45BMore
Lemborexanthsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Lemborexanthsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Lemborexanthsa05217Basal cell carcinoma7.91E-035Q13635, P04628, P49841, Q9UJU2, P24522PTCH1, WNT1, GSK3B, LEF1, GADD45AMore
Lemborexanthsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Lemborexanthsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Lemborexanthsa05220Chronic myeloid leukemia2.22E-058Q13547, Q13485, P25963, P84022, P31751, P42338, P04049, O75293HDAC1, SMAD4, NFKBIA, SMAD3, AKT2, PIK3CB, RAF1, GADD45BMore
Lemborexanthsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Lemborexanthsa05222Small cell lung cancer3.73E-047P31751, Q13489, P10415, P25963, Q13077, O00463, P24522AKT2, BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Lemborexanthsa05223Non-small cell lung cancer3.89E-055P31751, P10826, P04049, Q9HC35, O75293AKT2, RARB, RAF1, EML4, GADD45BMore
Lemborexanthsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Lemborexanthsa05225Hepatocellular carcinoma1.81E-054P04049, Q92529, P08069, P51531RAF1, SHC3, IGF1R, SMARCA2More
Lemborexanthsa05226Gastric cancer2.61E-057P04049, Q02750, P31751, O15169, P84022, Q13485, P10415RAF1, MAP2K1, AKT2, AXIN1, SMAD3, SMAD4, BCL2More
Lemborexanthsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Lemborexanthsa05231Choline metabolism in cancer2.31E-0811P04049, P31751, Q9NRA1, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494, P17252RAF1, AKT2, PDGFC, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1, PRKCAMore
Lemborexanthsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer9.71E-2018P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P23458, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, JAK1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Lemborexanthsa05310Asthma3.13E-123P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Lemborexanthsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Lemborexanthsa05321Inflammatory bowel disease6.81E-208O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Lemborexanthsa05322Systemic lupus erythematosus6.11E-1218P08637, O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P14678, P12814, P05455FCGR3A, FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SNRPB, ACTN1, SSBMore
Lemborexanthsa05323Rheumatoid arthritis7.52E-068P01375, Q06643, P13765, Q13488, P10747, P09341, P19875, O60603TNF, LTB, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2More
Lemborexanthsa05330Allograft rejection5.42E-066P13765, P30511, P29965, P48023, P10747, P01375HLA-DOB, HLA-F, CD40LG, FASLG, CD28, TNFMore
Lemborexanthsa05332Graft-versus-host disease1.27E-177P13765, P48023, P30511, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, HLA-F, CD28, TNF, KLRC1, KLRD1More
Lemborexanthsa05340Primary immunodeficiency2.12E-066P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Lemborexanthsa05410Hypertrophic cardiomyopathy1.42E-032P26012, P09493ITGB8, TPM1More
Lemborexanthsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Lemborexanthsa05414Dilated cardiomyopathy3.78E-034P54284, P26012, P09493, P26678CACNB3, ITGB8, TPM1, PLNMore
Lemborexanthsa05415Diabetic cardiomyopathy2.01E-0510P17252, P30405, P14598, Q15080, Q16718, O14521, Q16539, P14780, P37173, P04406PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, MAPK14, MMP9, TGFBR2, GAPDHMore
Lemborexanthsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Lemborexanthsa05418Fluid shear stress and atherosclerosis2.37E-0713Q16539, P31751, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238MAPK14, AKT2, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Lemborexant (SDC: 13.33)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
O00767SCDStearoylNoneCoA desaturasePredicted10.16860.1870.19970.6581
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
Q9NZJ5EIF2AK3Eukaryotic translation initiation factor 2Nonealpha kinase 3Predicted10.09390.15740.63981.0015
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P13866SLC5A1Sodium/glucose cotransporter 1Predicted00.37190.11050.1050.512
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P10619CTSALysosomal protective proteinPredicted00.12260.15310.19010.5575
O60282KIF5CKinesin heavy chain isoform 5CPredicted00.06410.00550.59220.6352
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
Q15722LTB4RLeukotriene B4 receptor 1Predicted00.06770.219900.4736
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P20839IMPDH1InosineNone5'Nonemonophosphate dehydrogenase 1Predicted00.19280.13070.16530.5231
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
Q14145KEAP1KelchNonelike ECHNoneassociated protein 1Predicted10.02350.08370.40730.5864
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
P49760CLK2Dual specificity protein kinase CLK2Predicted00.03030.295100.6053
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
Q13370PDE3BcGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase BPredicted00.09060.16140.35580.7239
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
Q9Y6R4MAP3K4MitogenNoneactivated protein kinase kinase kinase 4Predicted00.35280.24520.1730.8399
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
Q9H2K8TAOK3Serine/threonineNoneprotein kinase TAO3Predicted00.06460.24520.14870.6715
Q9P289STK26Serine/threonineNoneprotein kinase 26Predicted10.02850.262800.5399
Q9Y6E0STK24Serine/threonineNoneprotein kinase 24Predicted00.54580.245200.7634
Q8IVH8MAP4K3MitogenNoneactivated protein kinase kinase kinase kinase 3Predicted00.38330.26730.14870.875
Q13523PRPF4BSerine/threonineNoneprotein kinase PRP4 homologPredicted00.13760.245200.5593
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
O95835LATS1Serine/threonineNoneprotein kinase LATS1Predicted00.43320.24520.02170.7288
O43283MAP3K13MitogenNoneactivated protein kinase kinase kinase 13Predicted00.45650.24520.14870.8674
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
O95747OXSR1Serine/threonineNoneprotein kinase OSR1Predicted00.18390.245200.5825
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
O14976GAKCyclinNoneGNoneassociated kinasePredicted10.57280.256200.7989
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
Q9H422HIPK3HomeodomainNoneinteracting protein kinase 3Predicted00.3650.25080.2180.902
O94806PRKD3Serine/threonineNoneprotein kinase D3Predicted00.23120.24340.16920.7715
Q00536PCTK1CyclinNonedependent kinase 16Predicted00.27140.25600.6478
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
Q16513PKN2Serine/threonineNoneprotein kinase N2Predicted00.04210.27780.33910.9157
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q9UEW8STK39STE20/SPS1Nonerelated prolineNonealanineNonerich protein kinasePredicted00.25730.245200.6191
Q96BR1SGK3Serine/threonineNoneprotein kinase Sgk3Predicted00.0260.26840.31140.8612
Q9NQU5PAK6Serine/threonineNoneprotein kinase PAK 6Predicted00.4090.26690.50031.2386
Q8NI60CABC1Atypical kinase COQ8A, mitochondrialPredicted00.62760.245200.8043
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
Q86Z02HIPK1HomeodomainNoneinteracting protein kinase 1Predicted00.46310.28160.2181.0128
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P32298GRK4G proteinNonecoupled receptor kinase 4Predicted00.03520.23860.29480.7896
Q15831STK11Serine/threonineNoneprotein kinase STK11Predicted00.15110.24410.45491.0186
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
Q8IVW4CDKL3CyclinNonedependent kinaseNonelike 3Predicted00.41490.241600.6906
Q13873BMPR2Bone morphogenetic protein receptor typeNone2Predicted10.34760.24520.35481.019
O75460ERN1Serine/threonineNoneprotein kinase/endoribonuclease IRE1Predicted10.68060.29440.5571.4862
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
Q16566CAMK4Calcium/calmodulinNonedependent protein kinase type IVPredicted00.07180.24410.61761.1417
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
P07332FESTyrosineNoneprotein kinase Fes/FpsPredicted00.27220.26280.15130.8131
Q99759MAP3K3MitogenNoneactivated protein kinase kinase kinase 3Predicted00.35450.24520.43781.1055
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P45985MAP2K4Dual specificity mitogenNoneactivated protein kinase kinase 4Predicted00.42480.24730.74031.4474
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P20292ALOX5APArachidonate 5NonelipoxygenaseNoneactivating proteinPredicted00.13030.24180.09070.6395
Q6V1X1DPP8Dipeptidyl peptidase 8Predicted00.28410.125900.3939
Q9H5J4ELOVL6Elongation of very long chain fatty acids protein 6Predicted00.07880.03270.16660.2713
Q9Y6K0CEPT1Choline/ethanolaminephosphotransferase 1Predicted00.22610.01630.15910.3047
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)