PharmaCoNets

PharmaCoNets of Larotrectinib (S_PCN: 45.27 )

Larotrectinib regulated-network (S_DN: 10.08)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Larotrectinib

hsa00030

Pentose phosphate pathway

9.38E-07

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Larotrectinib

hsa00071

Fatty acid degradation

3.50E-02

O75521, P00325, P11766, P33121

ECI2, ADH1B, ADH5, ACSL1

Larotrectinib

hsa00190

Oxidative phosphorylation

1.00E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Larotrectinib

hsa00220

Arginine biosynthesis

4.40E-02

P15104

GLUL

Larotrectinib

hsa00670

One carbon pool by folate

1.33E-02

P04818, Q99707

TYMS, MTR

Larotrectinib

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Larotrectinib

hsa00830

Retinol metabolism

2.20E-02

P00325, P11766, Q9BPW9, O75911

ADH1B, ADH5, DHRS9, DHRS3

Larotrectinib

hsa00983

Drug metabolism - other enzymes

3.32E-02

P04183, P32320, P05164

TK1, CDA, MPO

Larotrectinib

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Larotrectinib

hsa01230

Biosynthesis of amino acids

2.26E-03

P51854, P60891, P05089, P37837

TKTL1, PRPS1, ARG1, TALDO1

Larotrectinib

hsa01523

Antifolate resistance

2.09E-03

P41440, Q92820, P04818, P01375, P18054

SLC19A1, GGH, TYMS, TNF, ALOX12

Larotrectinib

hsa03010

Ribosome

7.34E-03

P62753, P62829, P62888, P61927, P61513, P36578

RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4

Larotrectinib

hsa03020

RNA polymerase

2.51E-02

P24928, P62487

POLR2A, POLR2G

Larotrectinib

hsa03320

PPAR signaling pathway

4.55E-02

O00767, Q02318

SCD, CYP27A1

Larotrectinib

hsa03450

Non-homologous end-joining

4.48E-03

P78527

PRKDC

Larotrectinib

hsa04012

ErbB signaling pathway

1.91E-02

P16333, P19174, P01106

NCK1, PLCG1, MYC

Larotrectinib

hsa04061

Viral protein interaction with cytokine and cytokine receptor

3.02E-02

P09341, P02775, Q13651

CXCL1, PPBP, IL10RA

Larotrectinib

hsa04064

NF-kappa B signaling pathway

1.40E-03

O00463, P14778, P01584, P01375, Q04759, Q13077, Q16548, P06239, Q8WV28, P24522, P09341, Q9NQC7

TRAF5, IL1R1, IL1B, TNF, PRKCQ, TRAF1, BCL2A1, LCK, BLNK, GADD45A, CXCL1, CYLD

Larotrectinib

hsa04070

Phosphatidylinositol signaling system

1.53E-02

Q86XP1, Q96DU7

DGKH, ITPKC

Larotrectinib

hsa04071

Sphingolipid signaling pathway

1.19E-02

P21453, Q9H228, P01375, Q13362

S1PR1, EDG8, TNF, PPP2R5C

Larotrectinib

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

Larotrectinib

hsa04110

Cell cycle

1.21E-03

Q9UBD5, P06493, P78527, Q14683, P30304, P33981, P01106

ORC3, CDK1, PRKDC, SMC1A, CDC25A, TTK, MYC

Larotrectinib

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Larotrectinib

hsa04217

Necroptosis

1.89E-06

P01375, P01568, P48023, Q13489, Q9NQC7, P42224, Q14765, P07900, P08238, P15104, P01584, Q6FI13, Q99878, Q93077, Q9H444, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, IL1B, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP4B, CHMP2A, PPID

Larotrectinib

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Larotrectinib

hsa04380

Osteoclast differentiation

2.05E-03

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPA

Larotrectinib

hsa04530

Tight junction

3.02E-02

Q8TEU7, O00501, P24844

RAPGEF6, CLDN5, MYL9

Larotrectinib

hsa04612

Antigen processing and presentation

3.84E-05

P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Larotrectinib

hsa04613

Neutrophil extracellular trap formation

1.86E-02

O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539

TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Larotrectinib

hsa04614

Renin-angiotensin system

2.74E-02

P15144, P08311, O75787

ANPEP, CTSG, ATP6AP2

Larotrectinib

hsa04621

NOD-like receptor signaling pathway

1.41E-04

P01584, P07900, Q14643, P10599, Q9H1Y0, P43490, O00463, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838

IL1B, HSP90AA1, ITPR1, TXN, ATG5, PBEF1, TRAF5, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Larotrectinib

hsa04623

Cytosolic DNA-sensing pathway

3.15E-02

P01568, P25963

IFNA21, NFKBIA

Larotrectinib

hsa04625

C-type lectin receptor signaling pathway

8.11E-03

Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539

CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14

Larotrectinib

hsa04640

Hematopoietic cell lineage

4.33E-03

P13612, P14778, P27930, P15144, P11836, P25063, P07766, P09693, P01732, P13765, P01375, P01584

ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, HLA-DOB, TNF, IL1B

Larotrectinib

hsa04650

Natural killer cell mediated cytotoxicity

3.19E-07

P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715

TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
Q04759	PRKCQ	Protein kinase C theta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.855
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
Q04759	PRKCQ	Protein kinase C theta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.849
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
Q04759	PRKCQ	Protein kinase C theta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.918
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
Q04759	PRKCQ	Protein kinase C theta type	P26717	KLRC2	NKG2-C type II integral membrane protein	0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
Q04759	PRKCQ	Protein kinase C theta type	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Larotrectinib

hsa04657

IL-17 signaling pathway

1.65E-04

P07900, O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, IL1B

Larotrectinib

hsa04658

Th1 and Th2 cell differentiation

1.40E-05

Q04759, P07766, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765, P23458

PRKCQ, CD3E, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOB, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q04759	PRKCQ	Protein kinase C theta type	Q14765	STAT4	Signal transducer and activator of transcription 4	0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
Q04759	PRKCQ	Protein kinase C theta type	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.867
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
Q04759	PRKCQ	Protein kinase C theta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.843
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q04759	PRKCQ	Protein kinase C theta type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.82
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Larotrectinib

hsa04659

Th17 cell differentiation

6.58E-05

Q04759, Q16539, P06239, P13765, P14778, Q9HBE5, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458

PRKCQ, MAPK14, LCK, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q04759	PRKCQ	Protein kinase C theta type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.82
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q04759	PRKCQ	Protein kinase C theta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.8
Q04759	PRKCQ	Protein kinase C theta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.843
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
Q04759	PRKCQ	Protein kinase C theta type	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.867
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Larotrectinib

hsa04660

T cell receptor signaling pathway

3.35E-05

P01375, Q04759, O95267, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
Q04759	PRKCQ	Protein kinase C theta type	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q04759	PRKCQ	Protein kinase C theta type	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.803
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
Q04759	PRKCQ	Protein kinase C theta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.861
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
Q04759	PRKCQ	Protein kinase C theta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.767
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Larotrectinib

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

Larotrectinib

hsa04710

Circadian rhythm

4.40E-02

O15516

CLOCK

Larotrectinib

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Larotrectinib

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Larotrectinib

hsa04750

Inflammatory mediator regulation of TRP channels

1.17E-02

P14778, P01584, P51828, P22694, Q16539, Q14643, Q04759, P0DP24

IL1R1, IL1B, ADCY7, PRKACB, MAPK14, ITPR1, PRKCQ, CALM2

Larotrectinib

hsa04912

GnRH signaling pathway

4.33E-02

P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694

ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB

Larotrectinib

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Larotrectinib

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Larotrectinib

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Larotrectinib

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Larotrectinib

hsa04932

Non-alcoholic fatty liver disease

2.36E-03

P01375, P49841, P48023, P01584, P12074, O15239

TNF, GSK3B, FASLG, IL1B, COX6A1, NDUFA1

Larotrectinib

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Larotrectinib

hsa04960

Aldosterone-regulated sodium reabsorption

4.40E-02

O00141

SGK

Larotrectinib

hsa04970

Salivary secretion

1.91E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

Larotrectinib

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Larotrectinib

hsa05140

Leishmaniasis

1.29E-03

P13612, O75015, P14598, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, Q16539, Q15080

ITGA4, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MAPK14, NCF4

Larotrectinib

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Larotrectinib

hsa05144

Malaria

1.52E-04

P60033, O60603, P01375, P35443, P01584, P26718

CD81, TLR2, TNF, THBS4, IL1B, KLRK1

Larotrectinib

hsa05146

Amoebiasis

8.10E-05

P01584, P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P12814, P08311

IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, ACTN1, CTSG

Larotrectinib

hsa05150

Staphylococcus aureus infection

1.02E-03

P21730, P21462, O75015, P59665, P59666, P12838, P49913

C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Larotrectinib

hsa05160

Hepatitis C

1.52E-03

P60033, O00501, P29728, P49841, P01375, P48023, P01106

CD81, CLDN5, OAS2, GSK3B, TNF, FASLG, MYC

Larotrectinib

hsa05168

Herpes simplex virus 1 infection

3.38E-03

P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212

Larotrectinib

hsa05169

Epstein-Barr virus infection

3.13E-02

P13765, Q13547, O00463, P24522, P01375, P29728, P07766, P09693, P20963

HLA-DOB, HDAC1, TRAF5, GADD45A, TNF, OAS2, CD3E, CD3G, CD247

Larotrectinib

hsa05171

Coronavirus disease - COVID-19

3.18E-03

P01584, P62753, P36578, P62888, P61927, P61513, P62829

IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23

Larotrectinib

hsa05202

Transcriptional misregulation in cancer

9.93E-04

P17844, P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

DDX5, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
Q04759	PRKCQ	Protein kinase C theta type	P14780	MMP9	Matrix metalloproteinase-9	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
Q04759	PRKCQ	Protein kinase C theta type	P27930	IL1R2	Interleukin-1 receptor type 2	-0.733
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q04759	PRKCQ	Protein kinase C theta type	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.745
Q04759	PRKCQ	Protein kinase C theta type	Q16548	BCL2A1	Bcl-2-related protein A1	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
Q04759	PRKCQ	Protein kinase C theta type	P05164	MPO	Myeloperoxidase	-0.88
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
Q04759	PRKCQ	Protein kinase C theta type	P12838	DEFA4	Neutrophil defensin 4	-0.833
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
Q04759	PRKCQ	Protein kinase C theta type	P08246	ELA2	Neutrophil elastase	-0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
Q04759	PRKCQ	Protein kinase C theta type	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
Q04759	PRKCQ	Protein kinase C theta type	Q13547	HDAC1	Histone deacetylase 1	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
Q04759	PRKCQ	Protein kinase C theta type	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819