PharmaCoNets of Lactulose (SPCN: 6.58 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Lactulosehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Lactulosehsa00071Fatty acid degradation3.77E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Lactulosehsa00500Starch and sucrose metabolism8.76E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Lactulosehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Lactulosehsa00970Aminoacyl-tRNA biosynthesis1.49E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Lactulosehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Lactulosehsa04061Viral protein interaction with cytokine and cytokine receptor2.91E-026P09341, P25024, P25025, P47992, Q9UBD3, P01375CXCL1, CXCR1, CXCR2, XCL1, XCL2, TNFMore
Lactulosehsa04080Neuroactive ligand-receptor interaction1.36E-039P08311, P48058, Q15722, Q9H228, P43657, P21462, P21730, P14416, P35318CTSG, GRIA4, LTB4R, EDG8, P2RY5, FPR1, C5AR1, DRD2, ADMMore
Lactulosehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Lactulosehsa04612Antigen processing and presentation1.03E-027P48382, P26715, P26717, Q13241, O43908, P01732, P01375RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Lactulosehsa04613Neutrophil extracellular trap formation1.31E-0211O60603, P05164, Q9UM07, Q13547, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, PADI4, HDAC1, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Lactulosehsa04640Hematopoietic cell lineage1.13E-028P13612, P14778, P27930, P15144, P07766, P09693, P01732, P01730ITGA4, IL1R1, IL1R2, ANPEP, CD3E, CD3G, CD8A, CD4More
Lactulosehsa04650Natural killer cell mediated cytotoxicity6.22E-0510P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Lactulosehsa04657IL-17 signaling pathway2.19E-026O00463, Q16539, P49841, P09341, P14780, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNFMore
Lactulosehsa04658Th1 and Th2 cell differentiation1.27E-049Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, P23771, Q9UL17PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, GATA3, TBX21More
Lactulosehsa04659Th17 cell differentiation1.64E-0410Q04759, Q16539, P01730, P06239, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, CD4, LCK, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Lactulosehsa04660T cell receptor signaling pathway6.29E-0410Q04759, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841PRKCQ, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Lactulosehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Lactulosehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Lactulosehsa04976Bile secretion3.87E-023O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Lactulosehsa05120Epithelial cell signaling in Helicobacter pylori infection3.46E-034Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Lactulosehsa05133Pertussis4.20E-021P0C0L4C4AMore
Lactulosehsa05135Yersinia infection1.52E-026P13612, P06239, Q16539, P49841, P01730, P01732ITGA4, LCK, MAPK14, GSK3B, CD4, CD8AMore
Lactulosehsa05140Leishmaniasis4.59E-025O75015, O60603, P01375, Q16539, Q15080FCGR3B, TLR2, TNF, MAPK14, NCF4More
Lactulosehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Lactulosehsa05144Malaria2.98E-036P69905, P68871, O60603, P01375, P35443, P26718HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Lactulosehsa05146Amoebiasis7.20E-059P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSGMore
Lactulosehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.79E-037P07766, P20963, P09693, P06239, Q04759, Q16539, P01730CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, CD4More
Lactulosehsa05340Primary immunodeficiency3.76E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Lactulosehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Lactulosehsa05418Fluid shear stress and atherosclerosis4.81E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Lactulose (SDC: 1.63)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O43451MGAMMaltaseNoneglucoamylasePredicted10.19540.16780.1910.6242
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)