PharmaCoNets of Lactose (SPCN: 10.05 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Lactosehsa00052Galactose metabolism1.51E-021P16278GLB1More
Lactosehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Lactosehsa00071Fatty acid degradation3.77E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Lactosehsa00220Arginine biosynthesis2.21E-022P15104, P49448GLUL, GLUD2More
Lactosehsa00250Alanine, aspartate and glutamate metabolism2.21E-022P49448, P15104GLUD2, GLULMore
Lactosehsa00500Starch and sucrose metabolism8.76E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Lactosehsa00511Other glycan degradation9.09E-031P16278GLB1More
Lactosehsa00531Glycosaminoglycan degradation1.51E-021P16278GLB1More
Lactosehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Lactosehsa00600Sphingolipid metabolism1.81E-021P16278GLB1More
Lactosehsa00604Glycosphingolipid biosynthesis - ganglio series9.09E-031P16278GLB1More
Lactosehsa00910Nitrogen metabolism2.21E-022P15104, P49448GLUL, GLUD2More
Lactosehsa00970Aminoacyl-tRNA biosynthesis1.46E-054O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Lactosehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Lactosehsa03010Ribosome4.16E-022P46777, P50914RPL5, RPL14More
Lactosehsa03030DNA replication1.81E-021P15927RPA2More
Lactosehsa03420Nucleotide excision repair1.51E-021P15927RPA2More
Lactosehsa03430Mismatch repair1.81E-021P15927RPA2More
Lactosehsa03440Homologous recombination1.81E-021P15927RPA2More
Lactosehsa03460Fanconi anemia pathway1.81E-021P15927RPA2More
Lactosehsa04061Viral protein interaction with cytokine and cytokine receptor2.91E-026P09341, P25024, P25025, P47992, Q9UBD3, P01375CXCL1, CXCR1, CXCR2, XCL1, XCL2, TNFMore
Lactosehsa04080Neuroactive ligand-receptor interaction1.36E-039P08311, P48058, Q15722, Q9H228, P43657, P21462, P21730, P14416, P35318CTSG, GRIA4, LTB4R, EDG8, P2RY5, FPR1, C5AR1, DRD2, ADMMore
Lactosehsa04218Cellular senescence2.19E-026P01106, Q9H422, P42338, Q16539, P24522, P30304MYC, HIPK3, PIK3CB, MAPK14, GADD45A, CDC25AMore
Lactosehsa04370VEGF signaling pathway4.16E-022P42338, Q16539PIK3CB, MAPK14More
Lactosehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Lactosehsa04612Antigen processing and presentation1.03E-027P48382, P26715, P26717, Q13241, O43908, P01732, P01375RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Lactosehsa04613Neutrophil extracellular trap formation1.31E-0211O60603, P05164, Q9UM07, Q13547, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, PADI4, HDAC1, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Lactosehsa04640Hematopoietic cell lineage1.13E-028P13612, P14778, P27930, P15144, P07766, P09693, P01732, P01730ITGA4, IL1R1, IL1R2, ANPEP, CD3E, CD3G, CD8A, CD4More
Lactosehsa04650Natural killer cell mediated cytotoxicity6.22E-0510P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Lactosehsa04657IL-17 signaling pathway2.19E-026O00463, Q16539, P49841, P09341, P14780, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNFMore
Lactosehsa04658Th1 and Th2 cell differentiation1.27E-049Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, P23771, Q9UL17PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, GATA3, TBX21More
Lactosehsa04659Th17 cell differentiation2.40E-0510Q04759, Q16539, P01730, P06239, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, CD4, LCK, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Lactosehsa04660T cell receptor signaling pathway6.29E-0410Q04759, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841PRKCQ, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Lactosehsa04724Glutamatergic synapse1.17E-024P48058, P43003, P50151, P15104GRIA4, SLC1A3, GNG10, GLULMore
Lactosehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Lactosehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Lactosehsa04973Carbohydrate digestion and absorption7.81E-032O43451, P42338MGAM, PIK3CBMore
Lactosehsa04976Bile secretion3.87E-023O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Lactosehsa05120Epithelial cell signaling in Helicobacter pylori infection3.46E-034Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Lactosehsa05133Pertussis4.20E-021P0C0L4C4AMore
Lactosehsa05135Yersinia infection1.93E-037P13612, P06239, Q16539, P42338, P49841, P01730, P01732ITGA4, LCK, MAPK14, PIK3CB, GSK3B, CD4, CD8AMore
Lactosehsa05140Leishmaniasis4.59E-025O75015, O60603, P01375, Q16539, Q15080FCGR3B, TLR2, TNF, MAPK14, NCF4More
Lactosehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Lactosehsa05144Malaria2.98E-036P69905, P68871, O60603, P01375, P35443, P26718HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Lactosehsa05146Amoebiasis7.20E-059P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSGMore
Lactosehsa05163Human cytomegalovirus infection2.62E-026P42338, P50151, P01106, P14778, Q13651, Q16539PIK3CB, GNG10, MYC, IL1R1, IL10RA, MAPK14More
Lactosehsa05166Human T-cell leukemia virus 1 infection1.78E-029P01106, O60566, P14778, P27930, P07766, P42338, P42773, P06239, P01730MYC, BUB1B, IL1R1, IL1R2, CD3E, PIK3CB, CDKN2C, LCK, CD4More
Lactosehsa05213Endometrial cancer3.83E-023P01106, P42338, P24522MYC, PIK3CB, GADD45AMore
Lactosehsa05224Breast cancer1.64E-024P42338, P01106, Q92837, P24522PIK3CB, MYC, FRAT1, GADD45AMore
Lactosehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.87E-048P42338, P07766, P20963, P09693, P06239, Q04759, Q16539, P01730PIK3CB, CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, CD4More
Lactosehsa05340Primary immunodeficiency3.76E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Lactosehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Lactosehsa05418Fluid shear stress and atherosclerosis3.77E-037Q16539, P42338, P10599, P14780, P01375, P14778, P27930MAPK14, PIK3CB, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Lactose (SDC: 1.59)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P16278GLB1BetaNonegalactosidaseReported10.6880.02440.3220.7148
O43451MGAMMaltaseNoneglucoamylasePredicted10.19540.16780.1910.6242
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P05162LGALS2GalectinNone2Predicted00.00380.018900.0396
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)