| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Lacosamide | hsa00030 | Pentose phosphate pathway | 8.52E-04 | 4 | P60891, P51854, P08237, P37837 | PRPS1, TKTL1, PFKM, TALDO1 | More | | | Lacosamide | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Lacosamide | hsa00190 | Oxidative phosphorylation | 1.00E-02 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Lacosamide | hsa00220 | Arginine biosynthesis | 1.21E-02 | 1 | P15104 | GLUL | More | | | Lacosamide | hsa00250 | Alanine, aspartate and glutamate metabolism | 2.42E-02 | 1 | P15104 | GLUL | More | | | Lacosamide | hsa00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 3.43E-02 | 1 | Q9NY97 | B3GNT2 | More | | | Lacosamide | hsa00565 | Ether lipid metabolism | 4.93E-02 | 1 | Q8N661 | TMEM86B | More | | | Lacosamide | hsa00630 | Glyoxylate and dicarboxylate metabolism | 2.48E-02 | 2 | P40926, P15104 | MDH2, GLUL | More | | | Lacosamide | hsa00860 | Porphyrin and chlorophyll metabolism | 1.69E-02 | 2 | P36551, P30043 | CPOX, BLVRB | More | | | Lacosamide | hsa00910 | Nitrogen metabolism | 2.42E-02 | 1 | P15104 | GLUL | More | | | Lacosamide | hsa00970 | Aminoacyl-tRNA biosynthesis | 2.12E-02 | 1 | P14868 | DARS | More | | | Lacosamide | hsa01100 | Metabolic pathways | 1.03E-02 | 28 | Q9Y234, P35790, Q16772, P15144, P30041, O14732, Q02153, Q16774, P20839, P00918, P10768, P55809, P06280, Q9Y6K0, P08237, P21399, Q9UHK6, P51854, Q86VZ5, Q9BVK2, P15907, O96024, P37837, P50213, P43490, Q969G6, Q13029, Q9NVH6 | LIPT1, CHKA, GSTA3, ANPEP, PRDX6, IMPA2, GUCY1B3, GUK1, IMPDH1, CA2, ESD, OXCT1, GLA, CEPT1, PFKM, ACO1, AMACR, TKTL1, SGMS1, ALG8, ST6GAL1, B3GALT4, TALDO1, IDH3A, PBEF1, RFK, PRDM2, TMLHE | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9Y234 | LIPT1 | Lipoyltransferase 1, mitochondrial | 0.778 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P35790 | CHKA | Choline kinase alpha | -0.856 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q16772 | GSTA3 | Glutathione S-transferase A3 | -0.768 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P15144 | ANPEP | Aminopeptidase N | 0.846 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P30041 | PRDX6 | Peroxiredoxin-6 | 0.785 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | O14732 | IMPA2 | Inositol monophosphatase 2 | 0.738 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q02153 | GUCY1B3 | Guanylate cyclase soluble subunit beta-1 | -0.774 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q16774 | GUK1 | Guanylate kinase | 0.757 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | 1 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P00918 | CA2 | Carbonic anhydrase 2 | 0.772 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P10768 | ESD | S-formylglutathione hydrolase | -0.701 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P55809 | OXCT1 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial | -0.744 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P06280 | GLA | Alpha-galactosidase A | 0.728 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9Y6K0 | CEPT1 | Choline/ethanolaminephosphotransferase 1 | 0.771 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P08237 | PFKM | ATP-dependent 6-phosphofructokinase, muscle type | 0.868 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P21399 | ACO1 | Cytoplasmic aconitate hydratase | -0.739 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9UHK6 | AMACR | Alpha-methylacyl-CoA racemase | -0.784 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P51854 | TKTL1 | Transketolase-like protein 1 | -0.753 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q86VZ5 | SGMS1 | Phosphatidylcholine:ceramide cholinephosphotransferase 1 | -0.81 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9BVK2 | ALG8 | Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase | -0.726 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P15907 | ST6GAL1 | Beta-galactoside alpha-2,6-sialyltransferase 1 | -0.827 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | O96024 | B3GALT4 | Beta-1,3-galactosyltransferase 4 | 0.797 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P37837 | TALDO1 | Transaldolase | 0.732 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P50213 | IDH3A | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | -0.732 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | 0.702 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q969G6 | RFK | Riboflavin kinase | 0.705 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q13029 | PRDM2 | PR domain zinc finger protein 2 | 0.744 | | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | Q9NVH6 | TMLHE | Trimethyllysine dioxygenase, mitochondrial | -0.721 |
| | Lacosamide | hsa01200 | Carbon metabolism | 1.81E-02 | 6 | P51854, P08237, P37837, P50213, P21399, P10768 | TKTL1, PFKM, TALDO1, IDH3A, ACO1, ESD | More | | | Lacosamide | hsa01210 | 2-Oxocarboxylic acid metabolism | 1.73E-02 | 2 | P21399, P50213 | ACO1, IDH3A | More | | | Lacosamide | hsa01230 | Biosynthesis of amino acids | 5.58E-05 | 8 | P08237, P51854, P60891, Q99707, P21399, P50213, P15104, P37837 | PFKM, TKTL1, PRPS1, MTR, ACO1, IDH3A, GLUL, TALDO1 | More | | | Lacosamide | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 1.82E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa01522 | Endocrine resistance | 3.41E-02 | 6 | P14780, P22694, Q9UM47, P08069, P10415, Q13323 | MMP9, PRKACB, NOTCH3, IGF1R, BCL2, BIK | More | | | Lacosamide | hsa02010 | ABC transporters | 4.93E-02 | 1 | Q8IZY2 | ABCA7 | More | | | Lacosamide | hsa03008 | Ribosome biogenesis in eukaryotes | 1.88E-02 | 3 | O14980, O60832, Q9BVP2 | XPO1, DKC1, GNL3 | More | | | Lacosamide | hsa03013 | RNA transport | 2.48E-05 | 12 | O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5 | XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3 | More | | | Lacosamide | hsa03040 | Spliceosome | 1.46E-02 | 4 | P17844, P51991, P61978, P11142 | DDX5, HNRPA3, HNRPK, HSPA8 | More | | | Lacosamide | hsa03050 | Proteasome | 1.21E-02 | 1 | P28074 | PSMB5 | More | | | Lacosamide | hsa03450 | Non-homologous end-joining | 4.21E-02 | 1 | P13010 | XRCC5 | More | | | Lacosamide | hsa04010 | MAPK signaling pathway | 4.15E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa04014 | Ras signaling pathway | 3.65E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa04015 | Rap1 signaling pathway | 2.99E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 4.48E-02 | 5 | P09341, P19875, P25024, P25025, P14784 | CXCL1, CXCL2, CXCR1, CXCR2, IL2RB | More | | | Lacosamide | hsa04062 | Chemokine signaling pathway | 1.83E-02 | 8 | P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151 | CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10 | More | | | Lacosamide | hsa04064 | NF-kappa B signaling pathway | 6.48E-04 | 16 | P10415, Q13489, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, P24522, P09341, P19875, Q06643 | BCL2, BIRC3, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, GADD45A, CXCL1, CXCL2, LTB | More | | | Lacosamide | hsa04066 | HIF-1 signaling pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa04068 | FoxO signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa04071 | Sphingolipid signaling pathway | 4.62E-05 | 8 | P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415 | PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2 | More | | | Lacosamide | hsa04072 | Phospholipase D signaling pathway | 4.48E-02 | 5 | P42338, P43657, P25024, P25025, P19174 | PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1 | More | | | Lacosamide | hsa04080 | Neuroactive ligand-receptor interaction | 4.72E-02 | 8 | P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581 | CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1 | More | | | Lacosamide | hsa04114 | Oocyte meiosis | 2.99E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa04136 | Autophagy - other | 5.92E-03 | 2 | O94817, Q9H1Y0 | ATG12, ATG5 | More | | | Lacosamide | hsa04140 | Autophagy - animal | 6.54E-02 | 6 | P08069, P22694, Q14643, P10415, Q9H1Y0, Q04759 | IGF1R, PRKACB, ITPR1, BCL2, ATG5, PRKCQ | More | | | Lacosamide | hsa04141 | Protein processing in endoplasmic reticulum | 1.91E-03 | 6 | P18848, Q15437, Q99941, P11142, P07900, Q9NR31 | ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1A | More | | | Lacosamide | hsa04142 | Lysosome | 2.64E-02 | 2 | Q99437, P25774 | ATP6V0B, CTSS | More | | | Lacosamide | hsa04145 | Phagosome | 9.10E-03 | 10 | O75015, Q15080, P14598, Q13509, Q99437, P05164, O60603, P35443, P13765, P25774 | FCGR3B, NCF4, NCF1, TUBB3, ATP6V0B, MPO, TLR2, THBS4, HLA-DOB, CTSS | More | | | Lacosamide | hsa04146 | Peroxisome | 2.42E-02 | 5 | O43933, P56589, Q9UKG9, O75521, P33121 | PEX1, PEX3, CROT, ECI2, ACSL1 | More | | | Lacosamide | hsa04150 | mTOR signaling pathway | 2.32E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa04151 | PI3K-Akt signaling pathway | 3.91E-03 | 7 | P62753, P27348, P07900, P22105, Q99941, P18848, O00141 | RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGK | More | | | Lacosamide | hsa04152 | AMPK signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa04211 | Longevity regulating pathway | 5.33E-03 | 4 | P08069, P51828, Q99941, P18848 | IGF1R, ADCY7, CREBL1, ATF4 | More | | | Lacosamide | hsa04213 | Longevity regulating pathway - multiple species | 1.17E-02 | 5 | P42338, P08069, Q9Y4H2, P11142, Q13547 | PIK3CB, IGF1R, IRS2, HSPA8, HDAC1 | More | | | Lacosamide | hsa04215 | Apoptosis - multiple species | 1.56E-02 | 2 | Q13489, P10415 | BIRC3, BCL2 | More | | | Lacosamide | hsa04217 | Necroptosis | 2.87E-03 | 8 | P01568, Q13489, P42224, P08238, Q6FI13, Q93077, O43633, Q08752 | IFNA21, BIRC3, STAT1, HSP90AB1, H2AC18; H2AC19, HIST1H2AC, CHMP2A, PPID | More | | | Lacosamide | hsa04261 | Adrenergic signaling in cardiomyocytes | 1.46E-02 | 4 | P51828, Q99941, P18848, Q13557 | ADCY7, CREBL1, ATF4, CAMK2D | More | | | Lacosamide | hsa04330 | Notch signaling pathway | 3.28E-03 | 4 | Q92542, P49768, Q92830, P78504 | NCSTN, PSEN1, KAT2A, JAG1 | More | | | Lacosamide | hsa04340 | Hedgehog signaling pathway | 3.46E-02 | 4 | P49841, P22694, Q13635, P10415 | GSK3B, PRKACB, PTCH1, BCL2 | More | | | Lacosamide | hsa04390 | Hippo signaling pathway | 2.08E-02 | 3 | P84022, Q13485, Q13489 | SMAD3, SMAD4, BIRC3 | More | | | Lacosamide | hsa04510 | Focal adhesion | 3.48E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa04520 | Adherens junction | 8.29E-03 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa04610 | Complement and coagulation cascades | 7.40E-04 | 3 | P00734, P0C0L4, P21730 | F2, C4A, C5AR1 | More | | | Lacosamide | hsa04612 | Antigen processing and presentation | 2.40E-02 | 8 | P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375 | HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF | More | | | Lacosamide | hsa04613 | Neutrophil extracellular trap formation | 1.86E-05 | 16 | P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539 | PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | | Lacosamide | hsa04621 | NOD-like receptor signaling pathway | 2.62E-02 | 11 | Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838 | MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4 | More | | | Lacosamide | hsa04623 | Cytosolic DNA-sensing pathway | 3.15E-02 | 2 | P01568, P25963 | IFNA21, NFKBIA | More | | | Lacosamide | hsa04640 | Hematopoietic cell lineage | 1.37E-02 | 7 | P14778, P27930, P11215, P25063, P07766, P01732, P09564 | IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7 | More | | | Lacosamide | hsa04650 | Natural killer cell mediated cytotoxicity | 2.48E-03 | 8 | P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931 | PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3 | More | | | Lacosamide | hsa04657 | IL-17 signaling pathway | 5.21E-03 | 8 | O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375 | TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF | More | | | Lacosamide | hsa04658 | Th1 and Th2 cell differentiation | 1.54E-05 | 13 | Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761 | PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | | Lacosamide | hsa04659 | Th17 cell differentiation | 1.43E-04 | 11 | P25963, Q04759, P19174, P06239, P14784, P14778, Q9UL17, P84022, Q13485, P07766, P20963 | NFKBIA, PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, SMAD3, SMAD4, CD3E, CD247 | More | | | Lacosamide | hsa04660 | T cell receptor signaling pathway | 5.05E-05 | 15 | P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841 | TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B | More | | | Lacosamide | hsa04666 | Fc gamma R-mediated phagocytosis | 3.08E-02 | 5 | O75015, P06396, O14494, P14598, P17252 | FCGR3B, GSN, PLPP1, NCF1, PRKCA | More | | | Lacosamide | hsa04714 | Thermogenesis | 3.31E-02 | 4 | P51828, P62753, P12074, O15239 | ADCY7, RPS6, COX6A1, NDUFA1 | More | | | Lacosamide | hsa04721 | Synaptic vesicle cycle | 3.15E-02 | 2 | Q13488, P31645 | TCIRG1, SLC6A4 | More | | | Lacosamide | hsa04725 | Cholinergic synapse | 2.17E-02 | 3 | P51828, P18848, Q13557 | ADCY7, ATF4, CAMK2D | More | | | Lacosamide | hsa04728 | Dopaminergic synapse | 4.78E-02 | 3 | Q99941, P18848, Q13557 | CREBL1, ATF4, CAMK2D | More | | | Lacosamide | hsa04730 | Long-term depression | 1.16E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa04750 | Inflammatory mediator regulation of TRP channels | 7.24E-03 | 5 | P14778, P19174, P42338, P24723, Q04759 | IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ | More | | | Lacosamide | hsa04911 | Insulin secretion | 4.03E-04 | 4 | P51828, Q99941, P18848, Q13557 | ADCY7, CREBL1, ATF4, CAMK2D | More | | | Lacosamide | hsa04912 | GnRH signaling pathway | 2.17E-02 | 3 | P51828, P18848, Q13557 | ADCY7, ATF4, CAMK2D | More | | | Lacosamide | hsa04913 | Ovarian steroidogenesis | 1.16E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa04914 | Progesterone-mediated oocyte maturation | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa04915 | Estrogen signaling pathway | 2.75E-03 | 5 | Q99941, P18848, P51828, P07900, P11142 | CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8 | More | | | Lacosamide | hsa04918 | Thyroid hormone synthesis | 1.69E-03 | 4 | P51828, Q99941, P18848, P02768 | ADCY7, CREBL1, ATF4, ALB | More | | | Lacosamide | hsa04923 | Regulation of lipolysis in adipocytes | 2.24E-02 | 3 | P07550, P42338, Q9Y4H2 | ADRB2, PIK3CB, IRS2 | More | | | Lacosamide | hsa04925 | Aldosterone synthesis and secretion | 1.69E-03 | 4 | Q99941, P18848, P51828, Q13557 | CREBL1, ATF4, ADCY7, CAMK2D | More | | | Lacosamide | hsa04926 | Relaxin signaling pathway | 3.34E-02 | 3 | Q99941, P18848, P51828 | CREBL1, ATF4, ADCY7 | More | | | Lacosamide | hsa04927 | Cortisol synthesis and secretion | 4.16E-03 | 3 | Q99941, P18848, P51828 | CREBL1, ATF4, ADCY7 | More | | | Lacosamide | hsa04928 | Parathyroid hormone synthesis, secretion and action | 2.17E-02 | 3 | P51828, Q99941, P18848 | ADCY7, CREBL1, ATF4 | More | | | Lacosamide | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.25E-02 | 3 | P84022, Q13485, P10415 | SMAD3, SMAD4, BCL2 | More | | | Lacosamide | hsa04934 | Cushing syndrome | 1.12E-03 | 4 | Q99941, P18848, P51828, Q13557 | CREBL1, ATF4, ADCY7, CAMK2D | More | | | Lacosamide | hsa04935 | Growth hormone synthesis, secretion and action | 2.72E-02 | 3 | P51828, Q99941, P18848 | ADCY7, CREBL1, ATF4 | More | | | Lacosamide | hsa04940 | Type I diabetes mellitus | 4.18E-02 | 3 | P10747, P13765, P01375 | CD28, HLA-DOB, TNF | More | | | Lacosamide | hsa04964 | Proximal tubule bicarbonate reclamation | 4.93E-02 | 1 | P00918 | CA2 | More | | | Lacosamide | hsa04966 | Collecting duct acid secretion | 4.93E-02 | 1 | P00918 | CA2 | More | | | Lacosamide | hsa04973 | Carbohydrate digestion and absorption | 1.29E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | | Lacosamide | hsa04975 | Fat digestion and absorption | 3.43E-02 | 1 | O14494 | PLPP1 | More | | | Lacosamide | hsa05017 | Spinocerebellar ataxia | 2.43E-02 | 1 | P28074 | PSMB5 | More | | | Lacosamide | hsa05030 | Cocaine addiction | 4.87E-02 | 2 | Q99941, P18848 | CREBL1, ATF4 | More | | | Lacosamide | hsa05031 | Amphetamine addiction | 6.41E-03 | 3 | Q13557, Q99941, P18848 | CAMK2D, CREBL1, ATF4 | More | | | Lacosamide | hsa05110 | Vibrio cholerae infection | 4.78E-02 | 1 | Q99437 | ATP6V0B | More | | | Lacosamide | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.78E-03 | 5 | P09341, P19875, P19174, P25024, P25025 | CXCL1, CXCL2, PLCG1, CXCR1, CXCR2 | More | | | Lacosamide | hsa05132 | Salmonella infection | 2.04E-02 | 4 | P25963, Q13489, P10415, Q9BQS8 | NFKBIA, BIRC3, BCL2, FYCO1 | More | | | Lacosamide | hsa05133 | Pertussis | 4.20E-02 | 1 | P0C0L4 | C4A | More | | | Lacosamide | hsa05134 | Legionellosis | 1.29E-02 | 4 | P11215, P11142, P09341, P19875 | ITGAM, HSPA8, CXCL1, CXCL2 | More | | | Lacosamide | hsa05140 | Leishmaniasis | 2.68E-05 | 12 | P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, P51617, Q15080 | ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, IRAK1, NCF4 | More | | | Lacosamide | hsa05143 | African trypanosomiasis | 1.31E-02 | 2 | P69905, P68871 | HBA2, HBB | More | | | Lacosamide | hsa05144 | Malaria | 3.32E-03 | 4 | P69905, P68871, O60603, P10145 | HBA2, HBB, TLR2, IL8 | More | | | Lacosamide | hsa05145 | Toxoplasmosis | 2.78E-02 | 3 | P25963, P10415, Q13489 | NFKBIA, BCL2, BIRC3 | More | | | Lacosamide | hsa05146 | Amoebiasis | 7.41E-05 | 12 | P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311 | CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG | More | | | Lacosamide | hsa05150 | Staphylococcus aureus infection | 3.25E-03 | 8 | P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, P49913 | C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, CAMP | More | | | Lacosamide | hsa05152 | Tuberculosis | 9.75E-03 | 11 | Q99437, O75015, P48382, O60603, P01375, P10415, P13765, P25774, P49913, Q9UDY8, P51617 | ATP6V0B, FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CTSS, CAMP, MALT1, IRAK1 | More | | | Lacosamide | hsa05161 | Hepatitis B | 9.85E-04 | 7 | Q99941, P18848, P25963, Q13485, P10415, P27348, P84022 | CREBL1, ATF4, NFKBIA, SMAD4, BCL2, YWHAQ, SMAD3 | More | | | Lacosamide | hsa05168 | Herpes simplex virus 1 infection | 3.38E-03 | 12 | P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6 | NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212 | More | | | Lacosamide | hsa05202 | Transcriptional misregulation in cancer | 6.44E-06 | 20 | Q12778, Q15532, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522 | FOXO1, SS18, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A | More | | | Lacosamide | hsa05203 | Viral carcinogenesis | 1.46E-02 | 4 | Q99941, P18848, P27348, P61978 | CREBL1, ATF4, YWHAQ, HNRPK | More | | | Lacosamide | hsa05205 | Proteoglycans in cancer | 3.48E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa05210 | Colorectal cancer | 1.78E-02 | 3 | P84022, Q13485, P10415 | SMAD3, SMAD4, BCL2 | More | | | Lacosamide | hsa05212 | Pancreatic cancer | 3.52E-02 | 2 | P84022, Q13485 | SMAD3, SMAD4 | More | | | Lacosamide | hsa05214 | Glioma | 9.95E-03 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa05215 | Prostate cancer | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa05218 | Melanoma | 6.63E-03 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa05220 | Chronic myeloid leukemia | 1.25E-02 | 3 | Q13485, P25963, P84022 | SMAD4, NFKBIA, SMAD3 | More | | | Lacosamide | hsa05222 | Small cell lung cancer | 1.50E-02 | 3 | Q13489, P10415, P25963 | BIRC3, BCL2, NFKBIA | More | | | Lacosamide | hsa05224 | Breast cancer | 1.49E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa05225 | Hepatocellular carcinoma | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Lacosamide | hsa05226 | Gastric cancer | 2.78E-02 | 3 | P84022, Q13485, P10415 | SMAD3, SMAD4, BCL2 | More | | | Lacosamide | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 8.27E-03 | 6 | P42338, P19174, P07766, P20963, P06239, Q04759 | PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQ | More | | | Lacosamide | hsa05310 | Asthma | 9.08E-04 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Lacosamide | hsa05321 | Inflammatory bowel disease | 9.03E-05 | 6 | O60603, P01375, P13765, Q14765, Q9UL17, P23771 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3 | More | | | Lacosamide | hsa05322 | Systemic lupus erythematosus | 2.82E-02 | 8 | O75015, P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455 | FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSB | More | | | Lacosamide | hsa05332 | Graft-versus-host disease | 1.64E-03 | 5 | P13765, P10747, P01375, P26715, Q13241 | HLA-DOB, CD28, TNF, KLRC1, KLRD1 | More | | | Lacosamide | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.93E-02 | 1 | P54284 | CACNB3 | More | | | Lacosamide | hsa05415 | Diabetic cardiomyopathy | 1.07E-02 | 6 | P17252, P14598, Q15080, Q16718, O14521, P04406 | PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDH | More | |
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