PharmaCoNets

PharmaCoNets of Ketotifen (S_PCN: 122.30 )

Ketotifen regulated-network (S_DN: 19.54)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Ketotifen

hsa00030

Pentose phosphate pathway

1.98E-05

P60891, P51854, P52209, P37837

PRPS1, TKTL1, PGD, TALDO1

Ketotifen

hsa00190

Oxidative phosphorylation

1.03E-05

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Ketotifen

hsa00220

Arginine biosynthesis

1.97E-02

P15104, P49448

GLUL, GLUD2

Ketotifen

hsa00250

Alanine, aspartate and glutamate metabolism

1.97E-02

P49448, P15104

GLUD2, GLUL

Ketotifen

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Ketotifen

hsa00670

One carbon pool by folate

3.15E-02

O95954, Q99707

FTCD, MTR

Ketotifen

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Ketotifen

hsa00860

Porphyrin and chlorophyll metabolism

3.15E-02

P36551, P30043

CPOX, BLVRB

Ketotifen

hsa00910

Nitrogen metabolism

1.97E-02

P15104, P49448

GLUL, GLUD2

Ketotifen

hsa00970

Aminoacyl-tRNA biosynthesis

2.24E-03

O95363, P14868, Q15046

FARS2, DARS, KARS

Ketotifen

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Ketotifen

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Ketotifen

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Ketotifen

hsa01522

Endocrine resistance

4.55E-02

P14780, P22694, Q9UM47, P10415, Q13323

MMP9, PRKACB, NOTCH3, BCL2, BIK

Ketotifen

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Ketotifen

hsa03013

RNA transport

7.52E-05

O14980, Q09161, P61326, Q9H307, Q7Z3B4, P35658, Q14152, O75822, Q14240, Q06787, P51114

XPO1, NCBP1, MAGOH, PNN, NUP54, NUP214, EIF3A, EIF3J, EIF4A2, FMR1, FXR1

Ketotifen

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Ketotifen

hsa03030

DNA replication

5.00E-02

P27694

RPA1

Ketotifen

hsa03040

Spliceosome

1.28E-05

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Ketotifen

hsa03050

Proteasome

1.21E-02

P28074

PSMB5

Ketotifen

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Ketotifen

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Ketotifen

hsa04010

MAPK signaling pathway

1.53E-02

Q9H2K8, Q12933

TAOK3, TRAF2

Ketotifen

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Ketotifen

hsa04015

Rap1 signaling pathway

1.79E-02

P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174

EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1

Ketotifen

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Ketotifen

hsa04062

Chemokine signaling pathway

5.65E-04

P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Ketotifen

hsa04064

NF-kappa B signaling pathway

8.74E-05

P10415, Q13489, P51617, O00463, P14778, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643

BCL2, BIRC3, IRAK1, TRAF5, IL1R1, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74

Ketotifen

hsa04070

Phosphatidylinositol signaling system

3.47E-02

P0DP23, Q14643, P23743, P17252

CALM1, ITPR1, DGKA, PRKCA

Ketotifen

hsa04071

Sphingolipid signaling pathway

5.55E-06

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q12933, Q02156

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, TRAF2, PRKCE

Ketotifen

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Ketotifen

hsa04080

Neuroactive ligand-receptor interaction

3.82E-03

P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2

Ketotifen

hsa04114

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Ketotifen

hsa04120

Ubiquitin mediated proteolysis

4.81E-03

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Ketotifen

hsa04140

Autophagy - animal

4.55E-02

P22694, Q14643, P10415, Q9H1Y0, Q04759

PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Ketotifen

hsa04145

Phagosome

7.48E-05

O75015, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Ketotifen

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Ketotifen

hsa04151

PI3K-Akt signaling pathway

7.37E-04

P42338, P43657, P25116, P09603, P20827, P49767, Q9GZP0, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P13612, P16144, O15335, Q13751, O60603, P14784, P01568, P10415, P17252, P30281

PIK3CB, P2RY5, F2R, CSF1, EFNA1, VEGFC, PDGFD, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGA4, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, BCL2, PRKCA, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.789
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.736
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.902
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P13612	ITGA4	Integrin alpha-4	0.77
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	O15335	CHAD	Chondroadherin	-0.729
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q13751	LAMB3	Laminin subunit beta-3	-0.794
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Ketotifen

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Ketotifen

hsa04217

Necroptosis

7.46E-06

P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, P10415, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP2A, PPID

Ketotifen

hsa04261

Adrenergic signaling in cardiomyocytes

2.31E-03

P09493, P07550, P22694, P18848, Q13362, P0DP23, P17252, P10415

TPM1, ADRB2, PRKACB, ATF4, PPP2R5C, CALM1, PRKCA, BCL2

Ketotifen

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Ketotifen

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Ketotifen

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Ketotifen

hsa04512

ECM-receptor interaction

4.41E-02

Q13751, P13612, O15335

LAMB3, ITGA4, CHAD

Ketotifen

hsa04514

Cell adhesion molecules

1.22E-02

P23229, P30511

ITGA6, HLA-F

Ketotifen

hsa04540

Gap junction

1.29E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Ketotifen

hsa04610

Complement and coagulation cascades

2.78E-03

P0C0L4

C4A

Ketotifen

hsa04612

Antigen processing and presentation

1.07E-03

Q14953, P26715, P26717, Q13241, P01732, P01375

KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Ketotifen

hsa04613

Neutrophil extracellular trap formation

9.50E-05

P17252, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Ketotifen

hsa04622

RIG-I-like receptor signaling pathway

2.47E-02

Q12933

TRAF2

Ketotifen

hsa04623

Cytosolic DNA-sensing pathway

3.15E-02

P01568, P25963

IFNA21, NFKBIA

Ketotifen

hsa04640

Hematopoietic cell lineage

1.37E-02

P14778, P27930, P11215, P25063, P07766, P01732, P09564

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7

Ketotifen

hsa04650

Natural killer cell mediated cytotoxicity

3.09E-07

P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, P26717, Q14953, P26715

PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1

Ketotifen

hsa04657

IL-17 signaling pathway

2.41E-02

P19875, P14780, P80188, P01375

CXCL2, MMP9, LCN2, TNF

Ketotifen

hsa04658

Th1 and Th2 cell differentiation

2.21E-04

Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761

PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3

Ketotifen

hsa04659

Th17 cell differentiation

9.05E-05

Q04759, P19174, P06239, P14784, P14778, Q9UL17, P84022, Q13485, P08238, P07766, P20963

PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD247

Ketotifen

hsa04660

T cell receptor signaling pathway

3.37E-03

Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239

PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCK

Ketotifen

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Ketotifen

hsa04664

Fc epsilon RI signaling pathway

2.16E-03

P42338, P07948, P19174, P09917, P20292

PIK3CB, LYN, PLCG1, ALOX5, ALOX5AP

Ketotifen

hsa04666

Fc gamma R-mediated phagocytosis

3.08E-02

O75015, P06396, O14494, P14598, P17252

FCGR3B, GSN, PLPP1, NCF1, PRKCA

Ketotifen

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

Ketotifen

hsa04672

Intestinal immune network for IgA production

3.76E-03

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Ketotifen

hsa04713

Circadian entrainment

2.60E-02

P0DP23, P17252, P62873, Q14643

CALM1, PRKCA, GNB1, ITPR1

Ketotifen

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Ketotifen

hsa04720

Long-term potentiation

1.95E-03

P17252, P16298, P0DP23, P51812, Q02750, Q14643

PRKCA, PPP3CB, CALM1, RPS6KA3, MAP2K1, ITPR1

Ketotifen

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Ketotifen

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Ketotifen

hsa04723

Retrograde endocannabinoid signaling

1.88E-02

Q14643, P17252, P62873, Q16718

ITPR1, PRKCA, GNB1, NDUFA5

Ketotifen

hsa04724

Glutamatergic synapse

9.51E-03

O15399, P63218, P50151, P15104

GRIN2D, GNG5, GNG10, GLUL

Ketotifen

hsa04725

Cholinergic synapse

1.88E-02

Q14643, P17252, P62873, P10415

ITPR1, PRKCA, GNB1, BCL2

Ketotifen

hsa04727

GABAergic synapse

2.33E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Ketotifen

hsa04728

Dopaminergic synapse

3.55E-02

Q14643, P17252, P62873, Q13362, P0DP23

ITPR1, PRKCA, GNB1, PPP2R5C, CALM1

Ketotifen

hsa04730

Long-term depression

5.09E-03

Q14344, P07948

GNA13, LYN

Ketotifen

hsa04744

Phototransduction

1.02E-02

P62873, P0DP23

GNB1, CALM1

Ketotifen

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Ketotifen

hsa04810

Regulation of actin cytoskeleton

2.68E-02

P23229, Q14344

ITGA6, GNA13

Ketotifen

hsa04912

GnRH signaling pathway

3.89E-02

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Ketotifen

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Ketotifen

hsa04914

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Ketotifen

hsa04922

Glucagon signaling pathway

3.47E-02

Q12778, Q13370, P0DP23, Q14643

FOXO1, PDE3B, CALM1, ITPR1

Ketotifen

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Ketotifen

hsa04924

Renin secretion

7.38E-04

P22694, P07550, Q14643, Q13370, P0DP23

PRKACB, ADRB2, ITPR1, PDE3B, CALM1

Ketotifen

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Ketotifen

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Ketotifen

hsa04930

Type II diabetes mellitus

2.47E-02

Q02156

PRKCE

Ketotifen

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Ketotifen

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.19E-03

P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174

SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1

Ketotifen

hsa04940

Type I diabetes mellitus

2.61E-03

P10747, P48023, P13765, P01375

CD28, FASLG, HLA-DOB, TNF

Ketotifen

hsa04962

Vasopressin-regulated water reabsorption

2.18E-02

P52566, P62491

ARHGDIB, RAB11A

Ketotifen

hsa04966

Collecting duct acid secretion

2.86E-02

Q13488, Q9Y666

TCIRG1, SLC12A7

Ketotifen

hsa04970

Salivary secretion

1.91E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

Ketotifen

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Ketotifen

hsa04974

Protein digestion and absorption

2.47E-02

Q7Z2H8

SLC36A1

Ketotifen

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Ketotifen

hsa05010

Alzheimer disease

4.45E-03

Q16718, O14521, Q14643, O15399, Q9NZJ5, P0DP23, Q13564, Q71U36, Q13509, P68371, P09603, P21796, Q08752

NDUFA5, SDHD, ITPR1, GRIN2D, EIF2AK3, CALM1, APPBP1, TUBA1A, TUBB3, TUBB2C, CSF1, VDAC1, PPID

Ketotifen

hsa05012

Parkinson disease

2.25E-02

Q16718, O14521, Q14643, P0DP23, Q13509, P68371

NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C

Ketotifen

hsa05017

Spinocerebellar ataxia

2.43E-02

P28074

PSMB5

Ketotifen

hsa05020

Prion disease

1.31E-03

Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539

NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14

Ketotifen

hsa05022

Pathways of neurodegeneration - multiple diseases

2.00E-04

Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, Q13561, P17252, Q16539, Q08752, P0DP23

ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, MAPK14, PPID, CALM1

Ketotifen

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Ketotifen

hsa05032

Morphine addiction

1.34E-02

P63218, P50151, Q07343, P43250

GNG5, GNG10, PDE4B, GRK6

Ketotifen

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.78E-03

P09341, P19875, P19174, P25024, P25025

CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Ketotifen

hsa05131

Shigellosis

3.33E-03

Q12933, P68431, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752

TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID

Ketotifen

hsa05132

Salmonella infection

1.11E-02

Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371

LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Ketotifen

hsa05133

Pertussis

4.94E-02

P0C0L4

C4A

Ketotifen

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Ketotifen

hsa05140

Leishmaniasis

3.76E-06

O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, P51617, Q15080

FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, IRAK1, NCF4

Ketotifen

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Ketotifen

hsa05144

Malaria

1.91E-02

P01375, P35443, P26718

TNF, THBS4, KLRK1

Ketotifen

hsa05145

Toxoplasmosis

1.11E-02

P10415, Q13489, P42224, P13765, O60603, P29965

BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Ketotifen

hsa05146

Amoebiasis

2.05E-05

P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814

CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1

Ketotifen

hsa05150

Staphylococcus aureus infection

1.65E-02

P21730, P21462, O75015, P13765, Q16581, P49913

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMP

Ketotifen

hsa05152

Tuberculosis

3.37E-05

Q13488, P0DP23, O75015, P42224, P48382, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, P51617

TCIRG1, CALM1, FCGR3B, STAT1, RFX5, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, IRAK1

Ketotifen

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Ketotifen

hsa05163

Human cytomegalovirus infection

4.31E-02

P30511, Q14344

HLA-F, GNA13

Ketotifen

hsa05165

Human papillomavirus infection

3.10E-02

P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315

ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM

Ketotifen

hsa05167

Kaposi sarcoma-associated herpesvirus infection

3.04E-03

P01568, P42224, P62873, P62879, P16298, Q14643, Q02750, P0DP23, P0CG47, Q9UJU2

IFNA21, STAT1, GNB1, GNB2, PPP3CB, ITPR1, MAP2K1, CALM1, UBB, LEF1

Ketotifen

hsa05168

Herpes simplex virus 1 infection

3.38E-03

P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212

Ketotifen

hsa05170

Human immunodeficiency virus 1 infection

8.44E-05

Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5, P20333

MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2, TNFRSF1B

Ketotifen

hsa05200

Pathways in cancer

1.55E-03

Q13751, P42338, P08238, P42224, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P49767, Q12778, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784

LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, FOXO1, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Ketotifen

hsa05202

Transcriptional misregulation in cancer

2.35E-02

Q12778, Q15532, P14780, P14923, Q16548, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0, P24522

FOXO1, SS18, MMP9, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11B, GADD45A

Ketotifen

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Ketotifen

hsa05212

Pancreatic cancer

3.94E-02

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Ketotifen

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Ketotifen

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Ketotifen

hsa05226

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Ketotifen

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

8.27E-03

P42338, P19174, P07766, P20963, P06239, Q04759

PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQ

Ketotifen

hsa05310

Asthma

1.92E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Ketotifen

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Ketotifen

hsa05321

Inflammatory bowel disease

6.75E-04

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Ketotifen

hsa05322

Systemic lupus erythematosus

5.06E-04

O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, P68431, P05455

FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB

Ketotifen

hsa05323

Rheumatoid arthritis

1.29E-02

P13765, Q13488, P10747, O60603

HLA-DOB, TCIRG1, CD28, TLR2

Ketotifen

hsa05330

Allograft rejection

1.04E-03

P13765, P29965, P48023, P10747, P01375

HLA-DOB, CD40LG, FASLG, CD28, TNF

Ketotifen

hsa05332

Graft-versus-host disease

7.00E-05

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Ketotifen

hsa05415

Diabetic cardiomyopathy

5.60E-05

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH

Ketotifen

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Community members of Ketotifen (S_DC: 6.26)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

PGD

6Nonephosphogluconate dehydrogenase, decarboxylating

Reported

0.195

0.1454

0.2642

0.6525

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

Q9UBU7

DBF4

Protein DBF4 homolog A

Predicted

0.0075

0.1961

0.259

0.655

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P61088

UBE2N

UbiquitinNoneconjugating enzyme E2 N

Predicted

0.1102

0.3825

0.3736

1.1937

P30531

SLC6A1

SodiumNone and chlorideNonedependent GABA transporter 1

Predicted

0.0889

0.5202

0.1047

1.1894

P22894

MMP8

Neutrophil collagenase

Predicted

0.1061

0.357

0.767

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P17252

PRKCA

Protein kinase C alpha type

Predicted

0.1409

0.6948

2.4601

Q02156

PRKCE

Protein kinase C epsilon type

Predicted

0.1175

0.5287

0.5377

1.6539

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P28074

PSMB5

Proteasome subunit beta typeNone5

Predicted

0.2839

0.4723

0.5439

1.6305

P27694

RPA1

Replication protein A 70 kDa DNANonebinding subunit

Predicted

0.2273

0.1756

0.2746

0.7395

Gene name	UniProt_ID	Bioactivity	Value (nM)
PGD	P52209	IC50	8400
PGD	P52209	Ki	8300

PharmaCoNets of Ketotifen (SPCN: 122.30 )

Ketotifen regulated-network (SDN: 19.54)

Community members of Ketotifen (SDC: 6.26)

PharmaCoNets of Ketotifen (S_PCN: 122.30 )

Ketotifen regulated-network (S_DN: 19.54)

Community members of Ketotifen (S_DC: 6.26)