PharmaCoNets of Ketoconazole (SPCN: 161.34 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ketoconazolehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Ketoconazolehsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Ketoconazolehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Ketoconazolehsa00220Arginine biosynthesis1.26E-033P15104, P05089, P49448GLUL, ARG1, GLUD2More
Ketoconazolehsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Ketoconazolehsa00280Valine, leucine and isoleucine degradation4.31E-022P26440, Q02252IVD, ALDH6A1More
Ketoconazolehsa00310Lysine degradation3.15E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Ketoconazolehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Ketoconazolehsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Ketoconazolehsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Ketoconazolehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Ketoconazolehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Ketoconazolehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Ketoconazolehsa00630Glyoxylate and dicarboxylate metabolism1.48E-042P40925, P15104MDH1, GLULMore
Ketoconazolehsa00730Thiamine metabolism1.29E-053Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Ketoconazolehsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Ketoconazolehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Ketoconazolehsa00830Retinol metabolism2.27E-035P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Ketoconazolehsa00860Porphyrin and chlorophyll metabolism5.29E-032P53004, P30043BLVRA, BLVRBMore
Ketoconazolehsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Ketoconazolehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Ketoconazolehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Ketoconazolehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Ketoconazolehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Ketoconazolehsa01230Biosynthesis of amino acids5.53E-032P15104, P37837GLUL, TALDO1More
Ketoconazolehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Ketoconazolehsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Ketoconazolehsa01523Antifolate resistance2.04E-022P04818, P18054TYMS, ALOX12More
Ketoconazolehsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Ketoconazolehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Ketoconazolehsa03013RNA transport8.19E-047Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2More
Ketoconazolehsa03015mRNA surveillance pathway4.42E-024O60942, O43148, P52298, Q53GS7RNGTT, RNMT, NCBP2, GLE1More
Ketoconazolehsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Ketoconazolehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Ketoconazolehsa03040Spliceosome3.79E-0817Q14562, O43143, O60508, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Ketoconazolehsa03050Proteasome4.83E-021P55036PSMD4More
Ketoconazolehsa03060Protein export1.43E-022P37108, Q15005SRP14, SPCS2More
Ketoconazolehsa03320PPAR signaling pathway4.55E-022O00767, Q02318SCD, CYP27A1More
Ketoconazolehsa03450Non-homologous end-joining1.58E-043Q9NP87, P78527, P13010POLM, PRKDC, XRCC5More
Ketoconazolehsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Ketoconazolehsa04012ErbB signaling pathway1.66E-037P21860, P16333, Q13557, P19174, O14944, P42338, P01106ERBB3, NCK1, CAMK2D, PLCG1, EREG, PIK3CB, MYCMore
Ketoconazolehsa04014Ras signaling pathway1.72E-0411P42338, P20827, Q9NRA1, P49767, P08069, Q13009, P0DP23, P62873, P63218, P50151, P19174PIK3CB, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Ketoconazolehsa04015Rap1 signaling pathway1.42E-039P20827, Q9NRA1, P49767, P08069, P11215, Q13009, P42338, P0DP23, P19174EFNA1, PDGFC, VEGFC, IGF1R, ITGAM, TIAM1, PIK3CB, CALM1, PLCG1More
Ketoconazolehsa04020Calcium signaling pathway1.09E-0412P27987, Q96DU7, P21796, P45880, Q13557, P21860, P19174, P0DP23, P51828, P23634, Q9NRA1, P49767ITPKB, ITPKC, VDAC1, VDAC2, CAMK2D, ERBB3, PLCG1, CALM1, ADCY7, ATP2B4, PDGFC, VEGFCMore
Ketoconazolehsa04022cGMP-PKG signaling pathway4.72E-024Q99941, P23634, P51828, P45880CREBL1, ATP2B4, ADCY7, VDAC2More
Ketoconazolehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Ketoconazolehsa04061Viral protein interaction with cytokine and cytokine receptor1.33E-037P09341, P25024, P02775, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCR1, PPBP, XCL1, XCL2, IL10RA, IL2RBMore
Ketoconazolehsa04062Chemokine signaling pathway9.17E-0616P25024, P09341, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q13009, P14598, P42224, P25963CXCR1, CXCL1, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, TIAM1, NCF1, STAT1, NFKBIAMore
Ketoconazolehsa04064NF-kappa B signaling pathway3.08E-0414O00463, P14778, P01584, P01375, Q04759, Q13077, Q16548, P07948, P06239, Q8WV28, P24522, P09341, Q06643, Q9NQC7TRAF5, IL1R1, IL1B, TNF, PRKCQ, TRAF1, BCL2A1, LYN, LCK, BLNK, GADD45A, CXCL1, LTB, CYLDMore
Ketoconazolehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Ketoconazolehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Ketoconazolehsa04070Phosphatidylinositol signaling system9.58E-047P19174, P0DP23, P42338, P23743, Q86XP1, P27987, Q96DU7PLCG1, CALM1, PIK3CB, DGKA, DGKH, ITPKB, ITPKCMore
Ketoconazolehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Ketoconazolehsa04072Phospholipase D signaling pathway4.67E-025P42338, P19174, Q14344, P23743, Q9NRA1PIK3CB, PLCG1, GNA13, DGKA, PDGFCMore
Ketoconazolehsa04110Cell cycle1.35E-021P78527PRKDCMore
Ketoconazolehsa04114Oocyte meiosis3.19E-035P51812, Q02750, P16298, Q17RY0, P08069RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1RMore
Ketoconazolehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Ketoconazolehsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Ketoconazolehsa04141Protein processing in endoplasmic reticulum3.64E-025Q99941, O75460, P11142, Q9H3Z4, P07900CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Ketoconazolehsa04142Lysosome2.64E-022Q99437, P25774ATP6V0B, CTSSMore
Ketoconazolehsa04144Endocytosis2.81E-026Q13191, P11142, P25024, P43250, P14784, Q9Y5X3CBLB, HSPA8, CXCR1, GRK6, IL2RB, SNX5More
Ketoconazolehsa04145Phagosome8.90E-037P63261, Q15080, P14598, Q13509, P68371, Q99437, P25774ACTG1, NCF4, NCF1, TUBB3, TUBB2C, ATP6V0B, CTSSMore
Ketoconazolehsa04150mTOR signaling pathway7.74E-034P08069, Q02750, Q9NQL2, P51812IGF1R, MAP2K1, RRAGD, RPS6KA3More
Ketoconazolehsa04151PI3K-Akt signaling pathway5.62E-0312P42338, P01106, P20827, Q9NRA1, P49767, P08238, P62873, P63218, P50151, O15335, P14784, P01568PIK3CB, MYC, EFNA1, PDGFC, VEGFC, HSP90AB1, GNB1, GNG5, GNG10, CHAD, IL2RB, IFNA21More
Ketoconazolehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Ketoconazolehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Ketoconazolehsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Ketoconazolehsa04213Longevity regulating pathway - multiple species2.83E-033P08069, Q9Y4H2, Q13547IGF1R, IRS2, HDAC1More
Ketoconazolehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Ketoconazolehsa04217Necroptosis4.33E-0411P01375, P01568, P48023, Q13489, Q13546, Q14765, P07384, Q6FI13, Q99878, P10415, O43633TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT4, CAPN1, H2AC18; H2AC19, H2AC14, BCL2, CHMP2AMore
Ketoconazolehsa04261Adrenergic signaling in cardiomyocytes3.98E-024P51828, Q99941, Q13557, P23634ADCY7, CREBL1, CAMK2D, ATP2B4More
Ketoconazolehsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Ketoconazolehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Ketoconazolehsa04360Axon guidance2.87E-025P16333, P20827, O95631, P42338, P19174NCK1, EFNA1, NTN1, PIK3CB, PLCG1More
Ketoconazolehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Ketoconazolehsa04371Apelin signaling pathway2.41E-037P62873, P63218, P50151, Q13370, Q14814, Q14344, P0DP23GNB1, GNG5, GNG10, PDE3B, MEF2D, GNA13, CALM1More
Ketoconazolehsa04380Osteoclast differentiation2.05E-0312Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Ketoconazolehsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Ketoconazolehsa04510Focal adhesion1.54E-027O75369, Q15942, Q13489, P10415, P08069, P49767, P63261FLNB, ZYX, BIRC3, BCL2, IGF1R, VEGFC, ACTG1More
Ketoconazolehsa04520Adherens junction8.29E-031P08069IGF1RMore
Ketoconazolehsa04530Tight junction2.45E-036Q8TEU7, P16989, P56750, O00501, Q14247, P24844RAPGEF6, CSDA, CLDN17, CLDN5, CTTN, MYL9More
Ketoconazolehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Ketoconazolehsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Ketoconazolehsa04612Antigen processing and presentation1.75E-026P13765, P01730, P26715, P26717, Q13241, P01732HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8AMore
Ketoconazolehsa04613Neutrophil extracellular trap formation4.27E-0627P42338, P19174, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q93077, P58876, P62807, Q93079, Q16778, O60814, P68431, P21796, P14598, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539PIK3CB, PLCG1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, HIST1H2AC, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Ketoconazolehsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Ketoconazolehsa04620Toll-like receptor signaling pathway4.00E-024P01568, P42224, P25963, P42338IFNA21, STAT1, NFKBIA, PIK3CBMore
Ketoconazolehsa04623Cytosolic DNA-sensing pathway1.48E-033P01568, Q13546, P25963IFNA21, RIPK1, NFKBIAMore
Ketoconazolehsa04625C-type lectin receptor signaling pathway5.57E-0413Q9ULY5, P01584, Q9NQC7, P42224, P20749, P25963, Q14643, P01375, Q13191, P42338, P0DP24, P0DP23, Q16539CLEC4E, IL1B, CYLD, STAT1, BCL3, NFKBIA, ITPR1, TNF, CBLB, PIK3CB, CALM2, CALM1, MAPK14More
Ketoconazolehsa04640Hematopoietic cell lineage1.16E-0414P13612, P14778, P27930, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, IL1BMore
Ketoconazolehsa04650Natural killer cell mediated cytotoxicity4.42E-0514P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Ketoconazolehsa04657IL-17 signaling pathway3.31E-038O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Ketoconazolehsa04658Th1 and Th2 cell differentiation1.14E-0917P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Ketoconazolehsa04659Th17 cell differentiation6.59E-1020P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Ketoconazolehsa04660T cell receptor signaling pathway6.78E-0513P01375, Q04759, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Ketoconazolehsa04662B cell receptor signaling pathway1.23E-036P25963, P42338, P60033, P07948, P21854, Q8N149NFKBIA, PIK3CB, CD81, LYN, CD72, LILRA2More
Ketoconazolehsa04664Fc epsilon RI signaling pathway1.34E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Ketoconazolehsa04666Fc gamma R-mediated phagocytosis2.92E-024P07948, P42338, P19174, P14598LYN, PIK3CB, PLCG1, NCF1More
Ketoconazolehsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Ketoconazolehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Ketoconazolehsa04713Circadian entrainment4.00E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Ketoconazolehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Ketoconazolehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Ketoconazolehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Ketoconazolehsa04724Glutamatergic synapse1.62E-035O15399, P62873, P63218, P50151, P15104GRIN2D, GNB1, GNG5, GNG10, GLULMore
Ketoconazolehsa04725Cholinergic synapse2.92E-024P62873, P63218, P50151, P42338GNB1, GNG5, GNG10, PIK3CBMore
Ketoconazolehsa04727GABAergic synapse8.92E-044P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Ketoconazolehsa04730Long-term depression1.16E-021P08069IGF1RMore
Ketoconazolehsa04744Phototransduction1.32E-022P62873, P0DP23GNB1, CALM1More
Ketoconazolehsa04750Inflammatory mediator regulation of TRP channels1.72E-0413P14778, P01584, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Ketoconazolehsa04810Regulation of actin cytoskeleton2.61E-026P12814, Q13009, P42338, P11215, Q14344, Q9NRA1ACTN1, TIAM1, PIK3CB, ITGAM, GNA13, PDGFCMore
Ketoconazolehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Ketoconazolehsa04911Insulin secretion1.48E-023P51828, Q99941, Q13557ADCY7, CREBL1, CAMK2DMore
Ketoconazolehsa04912GnRH signaling pathway4.33E-026P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACBMore
Ketoconazolehsa04913Ovarian steroidogenesis1.16E-021P08069IGF1RMore
Ketoconazolehsa04914Progesterone-mediated oocyte maturation1.85E-038P08069, Q17RY0, P42338, Q13370, P30304, P08238, P51812, Q02750IGF1R, CPEB4, PIK3CB, PDE3B, CDC25A, HSP90AB1, RPS6KA3, MAP2K1More
Ketoconazolehsa04915Estrogen signaling pathway4.72E-024Q99941, P51828, P07900, P11142CREBL1, ADCY7, HSP90AA1, HSPA8More
Ketoconazolehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Ketoconazolehsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Ketoconazolehsa04925Aldosterone synthesis and secretion5.19E-034Q99941, P51828, Q13557, P23634CREBL1, ADCY7, CAMK2D, ATP2B4More
Ketoconazolehsa04926Relaxin signaling pathway8.74E-036P25963, P42338, P62873, P63218, P50151, P49767NFKBIA, PIK3CB, GNB1, GNG5, GNG10, VEGFCMore
Ketoconazolehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Ketoconazolehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Ketoconazolehsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Ketoconazolehsa04934Cushing syndrome3.48E-034Q99941, P51828, O15169, Q13557CREBL1, ADCY7, AXIN1, CAMK2DMore
Ketoconazolehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Ketoconazolehsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Ketoconazolehsa04971Gastric acid secretion1.48E-023P51828, P15311, Q13557ADCY7, VIL2, CAMK2DMore
Ketoconazolehsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Ketoconazolehsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Ketoconazolehsa05010Alzheimer disease2.07E-027Q92542, P05496, P12074, O75460, P01584, O15169, P45880NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2More
Ketoconazolehsa05012Parkinson disease4.01E-026P21796, P60604, P19174, P0DP23, Q71U36, Q13509VDAC1, UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3More
Ketoconazolehsa05017Spinocerebellar ataxia2.22E-024Q92915, O15399, P42338, P21796FGF14, GRIN2D, PIK3CB, VDAC1More
Ketoconazolehsa05020Prion disease1.37E-0311P01584, P46531, P11142, Q16718, O14521, P05496, P12074, P45880, P49841, Q99941, Q16539IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, VDAC2, GSK3B, CREBL1, MAPK14More
Ketoconazolehsa05022Pathways of neurodegeneration - multiple diseases1.25E-0313O15399, Q13509, P68371, P49841, P10415, Q16718, O14521, Q13561, Q16539, P07384, P04628, Q08752, P0DP23GRIN2D, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, DCTN2, MAPK14, CAPN1, WNT1, PPID, CALM1More
Ketoconazolehsa05032Morphine addiction7.60E-035P62873, P63218, P50151, Q13370, P43250GNB1, GNG5, GNG10, PDE3B, GRK6More
Ketoconazolehsa05034Alcoholism1.63E-0612Q13547, P0DP23, P62873, P63218, P50151, Q93077, P58876, P62807, Q93079, Q16778, O60814, P68431HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Ketoconazolehsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Ketoconazolehsa05132Salmonella infection5.20E-0515P25963, P08238, P01106, P63261, P42338, Q13546, Q13489, P10415, O75369, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, MYC, ACTG1, PIK3CB, RIPK1, BIRC3, BCL2, FLNB, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41More
Ketoconazolehsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Ketoconazolehsa05140Leishmaniasis2.29E-029P13612, O75015, P23458, P13765, O60603, P01375, P01584, Q16539, Q15080ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MAPK14, NCF4More
Ketoconazolehsa05143African trypanosomiasis3.01E-034P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Ketoconazolehsa05144Malaria2.43E-026P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Ketoconazolehsa05145Toxoplasmosis2.87E-035P25963, P10415, Q13489, P28068, Q16787NFKBIA, BCL2, BIRC3, HLA-DMB, LAMA3More
Ketoconazolehsa05146Amoebiasis1.86E-0310P01584, P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311IL1B, CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSGMore
Ketoconazolehsa05152Tuberculosis4.16E-022Q99437, P25774ATP6V0B, CTSSMore
Ketoconazolehsa05160Hepatitis C1.52E-037P60033, O00501, P29728, P49841, P01375, P48023, P01106CD81, CLDN5, OAS2, GSK3B, TNF, FASLG, MYCMore
Ketoconazolehsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Ketoconazolehsa05162Measles1.84E-027P01568, P25963, P42224, P14784, P07766, P42338, P11142IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8More
Ketoconazolehsa05163Human cytomegalovirus infection4.19E-0410P42338, P25963, P62873, P63218, P50151, P0DP23, Q14344, P01106, P30101, P01568PIK3CB, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, MYC, PDIA3, IFNA21More
Ketoconazolehsa05165Human papillomavirus infection2.01E-023Q16787, Q02930, Q13315LAMA3, CREB5, ATMMore
Ketoconazolehsa05166Human T-cell leukemia virus 1 infection2.91E-023Q02930, P28068, Q13315CREB5, HLA-DMB, ATMMore
Ketoconazolehsa05167Kaposi sarcoma-associated herpesvirus infection4.21E-0615P01568, P42224, P25963, P42338, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P01106, P0DP23, P0CG47IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, MYC, CALM1, UBBMore
Ketoconazolehsa05168Herpes simplex virus 1 infection1.91E-0317Q9UKJ0, Q06124, P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q13398, Q9NR11, Q03923, O75820, Q9UDV6, P10415PILRB, PTPN11, NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF302, ZNF85, ZNF189, ZNF212, BCL2More
Ketoconazolehsa05169Epstein-Barr virus infection1.94E-0516P13765, P01106, Q13547, O00463, P25963, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, P01568, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, NFKBIA, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, IFNA21, CD3E, CD3G, CD247More
Ketoconazolehsa05170Human immunodeficiency virus 1 infection5.72E-0515P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P25963, P19174, P07766, P20333PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, NFKBIA, PLCG1, CD3E, TNFRSF1BMore
Ketoconazolehsa05200Pathways in cancer1.82E-0317P42338, P08238, P42224, P25963, P19174, P01106, P43246, Q13547, P49767, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, HDAC1, VEGFC, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Ketoconazolehsa05202Transcriptional misregulation in cancer2.98E-0417P17844, P14780, P27930, Q16548, P11215, Q13077, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522DDX5, MMP9, IL1R2, BCL2A1, ITGAM, TRAF1, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Ketoconazolehsa05203Viral carcinogenesis2.90E-0513P42338, P06746, P07948, P29083, Q13547, Q15283, P12814, P25963, P58876, P62807, Q93079, Q16778, O60814PIK3CB, POLB, LYN, GTF2E1, HDAC1, RASA2, ACTN1, NFKBIA, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12More
Ketoconazolehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Ketoconazolehsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Ketoconazolehsa05206MicroRNAs in cancer4.00E-0413P30304, P09493, P15311, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P20827, P19174CDC25A, TPM1, VIL2, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, EFNA1, PLCG1More
Ketoconazolehsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Ketoconazolehsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Ketoconazolehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Ketoconazolehsa05214Glioma2.01E-035P08069, P0DP23, P42338, P19174, O75293IGF1R, CALM1, PIK3CB, PLCG1, GADD45BMore
Ketoconazolehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Ketoconazolehsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Ketoconazolehsa05218Melanoma2.77E-034P08069, Q9NRA1, P42338, O75293IGF1R, PDGFC, PIK3CB, GADD45BMore
Ketoconazolehsa05220Chronic myeloid leukemia1.14E-037Q13547, P01106, Q13485, P25963, P84022, P42338, O75293HDAC1, MYC, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45BMore
Ketoconazolehsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Ketoconazolehsa05224Breast cancer1.49E-021P08069IGF1RMore
Ketoconazolehsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Ketoconazolehsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Ketoconazolehsa05231Choline metabolism in cancer2.92E-035P42338, Q9NRA1, Q9Y259, P19174, P23743PIK3CB, PDGFC, CHKB, PLCG1, DGKAMore
Ketoconazolehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.08E-0414P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, P42224, O60603, Q04759, Q16539, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, STAT1, TLR2, PRKCQ, MAPK14, CD4More
Ketoconazolehsa05321Inflammatory bowel disease1.21E-027O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Ketoconazolehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Ketoconazolehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Ketoconazolehsa05332Graft-versus-host disease3.75E-035P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Ketoconazolehsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Ketoconazolehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Ketoconazole (SDC: 6.99)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Reported10.03150.949301.9143
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P40925MDH1Malate dehydrogenase, cytoplasmicPredicted00.35660.27460.24260.97
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P13866SLC5A1Sodium/glucose cotransporter 1Predicted00.37190.11050.1050.512
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
O15151MDM4Protein Mdm4Predicted00.10140.08980.24890.4791
O00767SCDStearoylNoneCoA desaturasePredicted10.16860.1870.19970.6581
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P78527PRKDCDNANonedependent protein kinase catalytic subunitPredicted00.1780.19440.24960.7273
P33260CYP2C18Cytochrome P450 2C18Predicted10.02390.07560.15280.316
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)