PharmaCoNets of Ketazolam (SPCN: 37.45 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ketazolamhsa00030Pentose phosphate pathway7.84E-032P06744, P37837GPI, TALDO1More
Ketazolamhsa00240Pyrimidine metabolism2.20E-023P21589, P32320, P04183NT5E, CDA, TK1More
Ketazolamhsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Ketazolamhsa00500Starch and sucrose metabolism3.88E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Ketazolamhsa00730Thiamine metabolism3.79E-022P05186, P24666ALPL, ACP1More
Ketazolamhsa00790Folate biosynthesis4.74E-022P07101, P42330TH, AKR1C3More
Ketazolamhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Ketazolamhsa00983Drug metabolism - other enzymes1.35E-023P04183, P32320, P05164TK1, CDA, MPOMore
Ketazolamhsa01200Carbon metabolism7.69E-033P06744, P37837, P40926GPI, TALDO1, MDH2More
Ketazolamhsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Ketazolamhsa03013RNA transport8.19E-047Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2More
Ketazolamhsa03040Spliceosome3.98E-024Q15427, P38159, P61978, P11142SF3B4, RBMX, HNRPK, HSPA8More
Ketazolamhsa03050Proteasome1.40E-021P55036PSMD4More
Ketazolamhsa03060Protein export1.43E-022P37108, Q15005SRP14, SPCS2More
Ketazolamhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Ketazolamhsa04012ErbB signaling pathway3.74E-023P21860, Q13557, O14944ERBB3, CAMK2D, EREGMore
Ketazolamhsa04014Ras signaling pathway1.74E-023Q15283, P61586, P62873RASA2, RHOA, GNB1More
Ketazolamhsa04020Calcium signaling pathway6.50E-046Q96DU7, P45880, Q13557, P21860, P51828, P23634ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4More
Ketazolamhsa04022cGMP-PKG signaling pathway4.72E-024Q99941, P23634, P51828, P45880CREBL1, ATP2B4, ADCY7, VDAC2More
Ketazolamhsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Ketazolamhsa04060Cytokine-cytokine receptor interaction3.33E-028P48551, Q9UBD3, P47992, P02775, P09341, P32248, P51684, P01730IFNAR2, XCL2, XCL1, PPBP, CXCL1, CCR7, CCR6, CD4More
Ketazolamhsa04061Viral protein interaction with cytokine and cytokine receptor4.51E-036P51684, P32248, P09341, P02775, P47992, Q9UBD3CCR6, CCR7, CXCL1, PPBP, XCL1, XCL2More
Ketazolamhsa04064NF-kappa B signaling pathway1.86E-0313P10415, Q13489, O00463, Q13546, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, P24522, P09341, Q9UNE0BCL2, BIRC3, TRAF5, RIPK1, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1, EDARMore
Ketazolamhsa04071Sphingolipid signaling pathway2.06E-027Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Ketazolamhsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Ketazolamhsa04080Neuroactive ligand-receptor interaction2.54E-027P08311, Q15722, Q9H228, P21462, P21730, Q16581, P35318CTSG, LTB4R, EDG8, FPR1, C5AR1, C3AR1, ADMMore
Ketazolamhsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Ketazolamhsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Ketazolamhsa04140Autophagy - animal2.09E-024Q9NQL2, Q14643, P10415, Q04759RRAGD, ITPR1, BCL2, PRKCQMore
Ketazolamhsa04141Protein processing in endoplasmic reticulum3.64E-025Q99941, O75460, P11142, Q9H3Z4, P07900CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Ketazolamhsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Ketazolamhsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Ketazolamhsa04261Adrenergic signaling in cardiomyocytes3.98E-024P51828, Q99941, Q13557, P23634ADCY7, CREBL1, CAMK2D, ATP2B4More
Ketazolamhsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Ketazolamhsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Ketazolamhsa04340Hedgehog signaling pathway1.43E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Ketazolamhsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Ketazolamhsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Ketazolamhsa04613Neutrophil extracellular trap formation1.37E-0212O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Ketazolamhsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Ketazolamhsa04621NOD-like receptor signaling pathway1.18E-0315Q16539, Q14643, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, P01375, P09341, P59665, P59666, P12838MAPK14, ITPR1, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, TNF, CXCL1, DEFA1; DEFA1B, DEFA3, DEFA4More
Ketazolamhsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Ketazolamhsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Ketazolamhsa04657IL-17 signaling pathway1.28E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Ketazolamhsa04658Th1 and Th2 cell differentiation1.70E-0410Q04759, P20963, P09693, Q16539, P01730, Q14765, P42226, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, CD4, STAT4, STAT6, GATA3, TBX21, HLA-DOBMore
Ketazolamhsa04659Th17 cell differentiation4.05E-039Q04759, Q16539, P01730, P42226, P13765, Q9UL17, P23771, P09693, P20963PRKCQ, MAPK14, CD4, STAT6, HLA-DOB, TBX21, GATA3, CD3G, CD247More
Ketazolamhsa04660T cell receptor signaling pathway1.07E-029P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, MAPK14, GSK3BMore
Ketazolamhsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Ketazolamhsa04710Circadian rhythm2.43E-021O15516CLOCKMore
Ketazolamhsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Ketazolamhsa04723Retrograde endocannabinoid signaling3.13E-032P48169, P62873GABRA4, GNB1More
Ketazolamhsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Ketazolamhsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Ketazolamhsa04727GABAergic synapse3.69E-022P62873, P48169GNB1, GABRA4More
Ketazolamhsa04742Taste transduction4.80E-021P48169GABRA4More
Ketazolamhsa04750Inflammatory mediator regulation of TRP channels3.74E-023P01584, P51828, Q13557IL1B, ADCY7, CAMK2DMore
Ketazolamhsa04911Insulin secretion1.48E-023P51828, Q99941, Q13557ADCY7, CREBL1, CAMK2DMore
Ketazolamhsa04915Estrogen signaling pathway4.72E-024Q99941, P51828, P07900, P11142CREBL1, ADCY7, HSP90AA1, HSPA8More
Ketazolamhsa04925Aldosterone synthesis and secretion5.19E-034Q99941, P51828, Q13557, P23634CREBL1, ADCY7, CAMK2D, ATP2B4More
Ketazolamhsa04934Cushing syndrome3.48E-034Q99941, P51828, O15169, Q13557CREBL1, ADCY7, AXIN1, CAMK2DMore
Ketazolamhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Ketazolamhsa04966Collecting duct acid secretion2.52E-022P02730, Q9Y666SLC4A1, SLC12A7More
Ketazolamhsa04971Gastric acid secretion1.48E-023P51828, P15311, Q13557ADCY7, VIL2, CAMK2DMore
Ketazolamhsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Ketazolamhsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Ketazolamhsa05010Alzheimer disease2.07E-027Q92542, P05496, P12074, O75460, P01584, O15169, P45880NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2More
Ketazolamhsa05020Prion disease1.81E-027P01584, P46531, P11142, P05496, P12074, P45880, Q99941IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1More
Ketazolamhsa05032Morphine addiction3.02E-065P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Ketazolamhsa05033Nicotine addiction2.43E-021P48169GABRA4More
Ketazolamhsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Ketazolamhsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Ketazolamhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Ketazolamhsa05150Staphylococcus aureus infection3.62E-038P21730, P21462, O75015, P13765, Q16581, P59665, P59666, P12838C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, DEFA1; DEFA1B, DEFA3, DEFA4More
Ketazolamhsa05163Human cytomegalovirus infection2.09E-024P62873, P61586, P63092, P61769GNB1, RHOA, GNAS, B2MMore
Ketazolamhsa05169Epstein-Barr virus infection5.93E-0314P13765, P04637, O00463, P16070, P10415, Q16539, P24522, Q8WV28, P48551, P01375, O60603, P29728, P09693, P20963HLA-DOB, TP53, TRAF5, CD44, BCL2, MAPK14, GADD45A, BLNK, IFNAR2, TNF, TLR2, OAS2, CD3G, CD247More
Ketazolamhsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Ketazolamhsa05202Transcriptional misregulation in cancer8.07E-0414Q15532, P14780, P27930, Q16548, Q13077, Q15652, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P24522SS18, MMP9, IL1R2, BCL2A1, TRAF1, JMJD1C, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, GADD45AMore
Ketazolamhsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Ketazolamhsa05213Endometrial cancer4.59E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Ketazolamhsa05214Glioma4.59E-023Q16566, P04637, P24522CAMK4, TP53, GADD45AMore
Ketazolamhsa05216Thyroid cancer1.35E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Ketazolamhsa05217Basal cell carcinoma1.80E-045Q13635, P49841, Q9UJU2, P04637, P24522PTCH1, GSK3B, LEF1, TP53, GADD45AMore
Ketazolamhsa05226Gastric cancer3.41E-025Q9UJU2, P04637, P24522, P14923, P10415LEF1, TP53, GADD45A, JUP, BCL2More
Ketazolamhsa05321Inflammatory bowel disease7.62E-047O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3More
Ketazolamhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Ketazolamhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Ketazolamhsa05414Dilated cardiomyopathy2.68E-022P09493, P26678TPM1, PLNMore

Community members of Ketazolam (SDC: 3.83)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
P06737PYGLGlycogen phosphorylase, liver formPredicted00.37330.22110.31690.9457
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P32249GPR183GNoneprotein coupled receptor 183Predicted00.0710.048500.1324
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P61586RHOATransforming protein RhoAPredicted00.35410.068911.3149
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)