PharmaCoNets

PharmaCoNets of Kappadione (S_PCN: 9.67 )

Kappadione regulated-network (S_DN: 9.21)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Kappadione

hsa00030

Pentose phosphate pathway

5.07E-03

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Kappadione

hsa00220

Arginine biosynthesis

1.54E-02

P05089, P49448

ARG1, GLUD2

Kappadione

hsa00500

Starch and sucrose metabolism

3.86E-02

O43451, P46976, P06737

MGAM, GYG1, PYGL

Kappadione

hsa00520

Amino sugar and nucleotide sugar metabolism

2.24E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Kappadione

hsa00630

Glyoxylate and dicarboxylate metabolism

1.29E-02

P40925, P15104

MDH1, GLUL

Kappadione

hsa00910

Nitrogen metabolism

2.93E-02

P22748, P49448

CA4, GLUD2

Kappadione

hsa00970

Aminoacyl-tRNA biosynthesis

5.32E-03

O95363, P54136, Q15046

FARS2, RARS1, KARS

Kappadione

hsa00983

Drug metabolism - other enzymes

2.16E-03

P04183, P32320, P05164

TK1, CDA, MPO

Kappadione

hsa03040

Spliceosome

1.26E-02

P17844, P51991, P61978, Q15365, Q01130, P11142

DDX5, HNRPA3, HNRPK, PCBP1, SFRS2, HSPA8

Kappadione

hsa03060

Protein export

3.37E-02

P37108, Q15005

SRP14, SPCS2

Kappadione

hsa04060

Cytokine-cytokine receptor interaction

1.74E-04

P14784, P27930, P14778, P08476, P26842, Q06643, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, P01375, P09341, P19875, P18510, P01730, Q93038

IL2RB, IL1R2, IL1R1, INHBA, CD27, LTB, IL10RA, IL21R, CXCR1, XCL2, XCL1, TNF, CXCL1, CXCL2, IL1RN, CD4, TNFRSF25

Kappadione

hsa04061

Viral protein interaction with cytokine and cytokine receptor

3.36E-04

P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNF

Kappadione

hsa04062

Chemokine signaling pathway

5.37E-03

P25024, P09341, P19875, P07948, P42338, P19174, P63218, P50151, P43250

CXCR1, CXCL1, CXCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6

Kappadione

hsa04064

NF-kappa B signaling pathway

3.72E-06

P10415, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q16548, P07948, P06239, Q13315, P24522, O75293, P09341, P19875, Q06643

BCL2, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, BCL2A1, LYN, LCK, ATM, GADD45A, GADD45B, CXCL1, CXCL2, LTB

Kappadione

hsa04071

Sphingolipid signaling pathway

2.25E-02

P21453, Q9H228, P01375, Q13362, P10415

S1PR1, EDG8, TNF, PPP2R5C, BCL2

Kappadione

hsa04080

Neuroactive ligand-receptor interaction

6.23E-03

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1

Kappadione

hsa04141

Protein processing in endoplasmic reticulum

6.04E-03

P18848, Q15437, Q99941, O75460, P11142, Q9H3Z4, P07900, Q9NR31

ATF4, SEC23B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, SAR1A

Kappadione

hsa04145

Phagosome

2.35E-02

Q15080, P05164, P78380, O60603, P35443, P13765

NCF4, MPO, OLR1, TLR2, THBS4, HLA-DOB

Kappadione

hsa04151

PI3K-Akt signaling pathway

9.80E-03

O43521, P27348, Q13362, P07900, P22105, P23458, Q99941, P18848, O00141, Q6ZUJ8

BCL2L11, YWHAQ, PPP2R5C, HSP90AA1, TNXB, JAK1, CREBL1, ATF4, SGK, PIK3AP1

Kappadione

hsa04210

Apoptosis

2.59E-02

P10415, O76075, P01375, P24522, Q16548, P43234, P18848, Q14643

BCL2, DFFB, TNF, GADD45A, BCL2A1, CTSO, ATF4, ITPR1

Kappadione

hsa04211

Longevity regulating pathway

4.57E-02

P51828, Q99941, P18848, Q96RR4

ADCY7, CREBL1, ATF4, CAMKK2

Kappadione

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Kappadione

hsa04217

Necroptosis

5.00E-03

P23458, Q9NQC7, P07900, P05141, P01584, Q9H444, O75351

JAK1, CYLD, HSP90AA1, SLC25A5, IL1B, CHMP4B, VPS4B

Kappadione

hsa04261

Adrenergic signaling in cardiomyocytes

1.26E-02

P67936, P51828, Q99941, P18848, Q13362, P23634

TPM4, ADCY7, CREBL1, ATF4, PPP2R5C, ATP2B4

Kappadione

hsa04340

Hedgehog signaling pathway

4.63E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Kappadione

hsa04610

Complement and coagulation cascades

3.16E-03

P00734, P0C0L4

F2, C4A

Kappadione

hsa04612

Antigen processing and presentation

7.95E-06

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Kappadione

hsa04613

Neutrophil extracellular trap formation

1.72E-02

O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, P21730, P21462

TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, C5AR1, FPR1

Kappadione

hsa04621

NOD-like receptor signaling pathway

2.39E-02

P01584, P07900, P23458, Q9H3M7, P43490

IL1B, HSP90AA1, JAK1, TXNIP, PBEF1

Kappadione

hsa04640

Hematopoietic cell lineage

2.66E-04

P13612, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF

Kappadione

hsa04650

Natural killer cell mediated cytotoxicity

7.60E-07

P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O75015, P26717, P26715

PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P24158	PRTN3	Myeloblastin	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.816
P51124	GZMM	Granzyme M	O60880	SH2D1A	SH2 domain-containing protein 1A	0.743
P49863	GZMK	Granzyme K	O60880	SH2D1A	SH2 domain-containing protein 1A	0.899
P08311	CTSG	Cathepsin G	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.92
P24158	PRTN3	Myeloblastin	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.729
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
P24158	PRTN3	Myeloblastin	Q13241	KLRD1	Natural killer cells antigen CD94	-0.732
P49863	GZMK	Granzyme K	Q13241	KLRD1	Natural killer cells antigen CD94	0.809
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P24158	PRTN3	Myeloblastin	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.76
P51124	GZMM	Granzyme M	P26718	KLRK1	NKG2-D type II integral membrane protein	0.713
P49863	GZMK	Granzyme K	P26718	KLRK1	NKG2-D type II integral membrane protein	0.96
P08311	CTSG	Cathepsin G	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.875
P49863	GZMK	Granzyme K	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.775
P24158	PRTN3	Myeloblastin	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.77
P49863	GZMK	Granzyme K	P26717	KLRC2	NKG2-C type II integral membrane protein	0.891
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P24158	PRTN3	Myeloblastin	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
P49863	GZMK	Granzyme K	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.891
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867

Kappadione

hsa04657

IL-17 signaling pathway

8.05E-04

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Kappadione

hsa04658

Th1 and Th2 cell differentiation

1.80E-10

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49863	GZMK	Granzyme K	Q04759	PRKCQ	Protein kinase C theta type	0.874
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P49863	GZMK	Granzyme K	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.756
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P49863	GZMK	Granzyme K	Q14765	STAT4	Signal transducer and activator of transcription 4	0.848
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P49863	GZMK	Granzyme K	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.768
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P51124	GZMM	Granzyme M	Q9UL17	TBX21	T-box transcription factor TBX21	0.755
P49863	GZMK	Granzyme K	Q9UL17	TBX21	T-box transcription factor TBX21	0.918
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P51124	GZMM	Granzyme M	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.887
P49863	GZMK	Granzyme K	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.882
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P51124	GZMM	Granzyme M	Q13761	RUNX3	Runt-related transcription factor 3	0.849
P49863	GZMK	Granzyme K	Q13761	RUNX3	Runt-related transcription factor 3	0.704

Kappadione

hsa04659

Th17 cell differentiation

9.49E-08

Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49863	GZMK	Granzyme K	Q04759	PRKCQ	Protein kinase C theta type	0.874
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P49863	GZMK	Granzyme K	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.756
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P51124	GZMM	Granzyme M	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.887
P49863	GZMK	Granzyme K	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.882
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P51124	GZMM	Granzyme M	P14778	IL1R1	Interleukin-1 receptor type 1	-0.886
P49863	GZMK	Granzyme K	Q9HBE5	IL21R	Interleukin-21 receptor	0.722
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763
P51124	GZMM	Granzyme M	Q9UL17	TBX21	T-box transcription factor TBX21	0.755
P49863	GZMK	Granzyme K	Q9UL17	TBX21	T-box transcription factor TBX21	0.918
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P49863	GZMK	Granzyme K	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.768
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888

Kappadione

hsa04660

T cell receptor signaling pathway

3.88E-07

P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P49863	GZMK	Granzyme K	Q04759	PRKCQ	Protein kinase C theta type	0.874
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
P49863	GZMK	Granzyme K	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.872
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
P49863	GZMK	Granzyme K	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.952
P08311	CTSG	Cathepsin G	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P49863	GZMK	Granzyme K	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.784
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P49863	GZMK	Granzyme K	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.793
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P49863	GZMK	Granzyme K	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.756
P49863	GZMK	Granzyme K	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.716

Kappadione

hsa04662

B cell receptor signaling pathway

1.07E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Kappadione

hsa04664

Fc epsilon RI signaling pathway

1.29E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Kappadione

hsa04668

TNF signaling pathway

3.19E-02

P01375, O00463, Q16539, P09341, P20749, Q13077, P14780

TNF, TRAF5, MAPK14, CXCL1, BCL3, TRAF1, MMP9

Kappadione

hsa04724

Glutamatergic synapse

2.81E-02

P43003, P63218, P50151, P15104

SLC1A3, GNG5, GNG10, GLUL

Kappadione

hsa04725

Cholinergic synapse

3.86E-02

P22694, Q14643, P18848, P10415

PRKACB, ITPR1, ATF4, BCL2

Kappadione

hsa04750

Inflammatory mediator regulation of TRP channels

4.06E-03

P14778, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759

IL1R1, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ

Kappadione

hsa04911

Insulin secretion

4.85E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Kappadione

hsa04915

Estrogen signaling pathway

1.20E-03

P14780, P22694, Q99941, P18848, P51828, P07900, P11142, Q14643, Q15788, P10415

MMP9, PRKACB, CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8, ITPR1, NCOA1, BCL2

Kappadione

hsa04918

Thyroid hormone synthesis

2.05E-03

P22694, P51828, Q99941, P18848, Q14643, P05543

PRKACB, ADCY7, CREBL1, ATF4, ITPR1, SERPINA7

Kappadione

hsa04925

Aldosterone synthesis and secretion

2.50E-02

Q99941, P18848, P51828, P23634

CREBL1, ATF4, ADCY7, ATP2B4

Kappadione

hsa04927

Cortisol synthesis and secretion

7.21E-04

Q14643, Q99941, P18848, P51828, P22694

ITPR1, CREBL1, ATF4, ADCY7, PRKACB

Kappadione

hsa04928

Parathyroid hormone synthesis, secretion and action

1.60E-02

Q14643, P22694, P23771, P18848, P10415

ITPR1, PRKACB, GATA3, ATF4, BCL2

Kappadione

hsa04934

Cushing syndrome

4.06E-02

Q14643, P22694, P49841, Q9UJU2, O00170

ITPR1, PRKACB, GSK3B, LEF1, AIP

Kappadione

hsa04964

Proximal tubule bicarbonate reclamation

2.93E-02

P22748, P49448

CA4, GLUD2

Kappadione

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Kappadione

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.78E-03

P09341, P19875, P19174, P25024, P07948

CXCL1, CXCL2, PLCG1, CXCR1, LYN

Kappadione

hsa05133

Pertussis

2.24E-02

P0DP23, P0C0L4

CALM1, C4A

Kappadione

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Kappadione

hsa05135

Yersinia infection

4.26E-02

P13612, P06239, Q16539, P01375, P49841, P01732

ITGA4, LCK, MAPK14, TNF, GSK3B, CD8A

Kappadione

hsa05143

African trypanosomiasis

4.81E-02

P69905, P68871

HBA2, HBB

Kappadione

hsa05144

Malaria

1.80E-02

O60603, P01375, P35443, P26718

TLR2, TNF, THBS4, KLRK1

Kappadione

hsa05146

Amoebiasis

1.05E-08

Q13751, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

LAMB3, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Kappadione

hsa05152

Tuberculosis

4.71E-02

P48382, O60603, P01375, P10415, P13765, Q9UDY8

RFX5, TLR2, TNF, BCL2, HLA-DOB, MALT1

Kappadione

hsa05163

Human cytomegalovirus infection

3.61E-03

P42338, P63218, P50151, P51828, P23458, P01106, P14778, P01584, P61073, Q13651, Q99941, P18848, P30101

PIK3CB, GNG5, GNG10, ADCY7, JAK1, MYC, IL1R1, IL1B, CXCR4, IL10RA, CREBL1, ATF4, PDIA3

Kappadione

hsa05167

Kaposi sarcoma-associated herpesvirus infection

7.60E-03

P42338, P63218, P50151, P09341, P19875, P19174, P07948, P01106

PIK3CB, GNG5, GNG10, CXCL1, CXCL2, PLCG1, LYN, MYC

Kappadione

hsa05169

Epstein-Barr virus infection

1.27E-02

P01106, Q13547, P42338, P07948, P30101, Q13761, O75293, P07766, P20963

MYC, HDAC1, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, CD3E, CD247

Kappadione

hsa05170

Human immunodeficiency virus 1 infection

3.15E-02

P42338, P63218, P50151, P30101, P01730, P19174, P07766, P20963

PIK3CB, GNG5, GNG10, PDIA3, CD4, PLCG1, CD3E, CD247

Kappadione

hsa05202

Transcriptional misregulation in cancer

4.42E-04

Q15532, Q13315, P14780, P27930, Q15744, Q16548, O15550, P05164, P12838, P08246, Q9C0K0, P24522

SS18, ATM, MMP9, IL1R2, CEBPE, BCL2A1, UTX, MPO, DEFA4, ELA2, BCL11B, GADD45A

Kappadione

hsa05203

Viral carcinogenesis

1.26E-02

Q99941, P18848, P23458, P27348, Q7KZF4, P61978

CREBL1, ATF4, JAK1, YWHAQ, SND1, HNRPK

Kappadione

hsa05217

Basal cell carcinoma

3.39E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Kappadione

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

6.30E-05

P42338, O95267, P19174, P07766, P20963, P09693, P06239, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, CD4

Kappadione

hsa05310

Asthma

5.72E-05

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Kappadione

hsa05321

Inflammatory bowel disease

7.40E-08

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Kappadione

hsa05322

Systemic lupus erythematosus

3.90E-02

P08246, P08311, P01375, P13765, Q16778, P12814

ELA2, CTSG, TNF, HLA-DOB, HIST2H2BE, ACTN1

Kappadione

hsa05323

Rheumatoid arthritis

2.72E-02

P01375, P13765, P09341, O60603

TNF, HLA-DOB, CXCL1, TLR2

Kappadione

hsa05332

Graft-versus-host disease

5.25E-05

P13765, P01375, P26715, Q13241

HLA-DOB, TNF, KLRC1, KLRD1

Community members of Kappadione (S_DC: 1.05)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

Prothrombin

0.0963

0.707

0.4977

1.9598

P22891

PROZ

Vitamin KNonedependent protein Z

Predicted

0.7981

0.0168

0.4327

P49863

GZMK

Granzyme K

Predicted

0.0107

0.0325

0.0704

P24158

PRTN3

Myeloblastin

Predicted

0.0516

0.0511

0.1281

P08311

CTSG

Cathepsin G

Predicted

0.4949

0.1874

0.6478

1.2701

P51124

GZMM

Granzyme M

Predicted

0.0528

0.0301

0.0867

PharmaCoNets of Kappadione (SPCN: 9.67 )

Kappadione regulated-network (SDN: 9.21)

Community members of Kappadione (SDC: 1.05)

PharmaCoNets of Kappadione (S_PCN: 9.67 )

Kappadione regulated-network (S_DN: 9.21)

Community members of Kappadione (S_DC: 1.05)