PharmaCoNets of Ixabepilone (SPCN: 9.48 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ixabepilonehsa00010Glycolysis / Gluconeogenesis1.18E-022P60174, P06744TPI1, GPIMore
Ixabepilonehsa00053Ascorbate and aldarate metabolism1.80E-022P51648, Q9UEF7ALDH3A2, KLMore
Ixabepilonehsa00310Lysine degradation4.27E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Ixabepilonehsa00561Glycerolipid metabolism4.36E-033O14494, P51648, P23743PLPP1, ALDH3A2, DGKAMore
Ixabepilonehsa00630Glyoxylate and dicarboxylate metabolism2.42E-022P40925, P15104MDH1, GLULMore
Ixabepilonehsa01200Carbon metabolism1.99E-022P06744, P60174GPI, TPI1More
Ixabepilonehsa01521EGFR tyrosine kinase inhibitor resistance2.90E-023P17252, P10415, Q9NRA1PRKCA, BCL2, PDGFCMore
Ixabepilonehsa01524Platinum drug resistance4.02E-024Q13315, P10415, Q13489, P43246ATM, BCL2, BIRC3, MSH2More
Ixabepilonehsa03040Spliceosome1.45E-0411Q14562, O43143, O60508, P26368, P52298, Q13595, Q07955, Q01130, P84103, Q13243, P11142DHX8, DHX15, CDC40, U2AF2, NCBP2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8More
Ixabepilonehsa04020Calcium signaling pathway2.09E-025Q16566, P17252, P25116, P0DP23, Q9NRA1CAMK4, PRKCA, F2R, CALM1, PDGFCMore
Ixabepilonehsa04064NF-kappa B signaling pathway3.04E-038P10415, Q13489, P25963, P51617, Q13546, Q9UDY8, Q13315, O75293BCL2, BIRC3, NFKBIA, IRAK1, RIPK1, MALT1, ATM, GADD45BMore
Ixabepilonehsa04071Sphingolipid signaling pathway2.03E-024P17252, P21453, P10415, P01042PRKCA, S1PR1, BCL2, KNG1More
Ixabepilonehsa04072Phospholipase D signaling pathway1.06E-025P25116, P17252, O14494, P23743, Q9NRA1F2R, PRKCA, PLPP1, DGKA, PDGFCMore
Ixabepilonehsa04141Protein processing in endoplasmic reticulum2.77E-025P27824, P30101, P60604, P11142, P08238CANX, PDIA3, UBE2G2, HSPA8, HSP90AB1More
Ixabepilonehsa04145Phagosome2.46E-036Q15080, P14598, Q13509, P68371, Q13488, P27824NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, CANXMore
Ixabepilonehsa04217Necroptosis3.69E-058P01568, Q13489, Q13546, P42224, P08238, Q6FI13, P10415, O43633IFNA21, BIRC3, RIPK1, STAT1, HSP90AB1, H2AC18; H2AC19, BCL2, CHMP2AMore
Ixabepilonehsa04371Apelin signaling pathway1.12E-039P62873, P63218, P50151, Q13370, Q14344, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD4, SMAD3, CAMK4, CALM1More
Ixabepilonehsa04520Adherens junction8.77E-034Q13485, P84022, O95863, Q15223SMAD4, SMAD3, SNAI1, PVRL1More
Ixabepilonehsa04540Gap junction5.44E-034P17252, Q13509, P68371, Q9NRA1PRKCA, TUBB3, TUBB2C, PDGFCMore
Ixabepilonehsa04620Toll-like receptor signaling pathway7.24E-035P51617, Q13546, P01568, P42224, P25963IRAK1, RIPK1, IFNA21, STAT1, NFKBIAMore
Ixabepilonehsa04621NOD-like receptor signaling pathway4.54E-027P08238, P42224, P01568, P25963, Q13489, P10415, Q13546HSP90AB1, STAT1, IFNA21, NFKBIA, BIRC3, BCL2, RIPK1More
Ixabepilonehsa04623Cytosolic DNA-sensing pathway4.52E-053P01568, Q13546, P25963IFNA21, RIPK1, NFKBIAMore
Ixabepilonehsa04659Th17 cell differentiation1.64E-025P19174, P84022, Q13485, P08238, P07766PLCG1, SMAD3, SMAD4, HSP90AB1, CD3EMore
Ixabepilonehsa04664Fc epsilon RI signaling pathway2.35E-023P07948, P19174, P09917LYN, PLCG1, ALOX5More
Ixabepilonehsa04666Fc gamma R-mediated phagocytosis2.81E-024P23528, O14494, P14598, P17252CFL1, PLPP1, NCF1, PRKCAMore
Ixabepilonehsa04710Circadian rhythm1.79E-021O15516CLOCKMore
Ixabepilonehsa04720Long-term potentiation2.05E-023P17252, Q16566, P0DP23PRKCA, CAMK4, CALM1More
Ixabepilonehsa04724Glutamatergic synapse4.43E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Ixabepilonehsa04725Cholinergic synapse8.04E-034P17252, P62873, Q16566, P10415PRKCA, GNB1, CAMK4, BCL2More
Ixabepilonehsa04727GABAergic synapse4.43E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Ixabepilonehsa04744Phototransduction8.61E-052P62873, P0DP23GNB1, CALM1More
Ixabepilonehsa04916Melanogenesis2.90E-023P0DP23, Q9UJU2, P17252CALM1, LEF1, PRKCAMore
Ixabepilonehsa04925Aldosterone synthesis and secretion3.91E-023P0DP23, P17252, Q16566CALM1, PRKCA, CAMK4More
Ixabepilonehsa04961Endocrine and other factor-regulated calcium reabsorption1.22E-023P20020, Q9UEF7, P17252ATP2B1, KL, PRKCAMore
Ixabepilonehsa05032Morphine addiction4.43E-023P63218, P50151, P43250GNG5, GNG10, GRK6More
Ixabepilonehsa05132Salmonella infection1.58E-0511P51617, P25963, P08238, Q9UJU2, Q13546, Q13489, P10415, O75369, Q13561, Q13509, P68371IRAK1, NFKBIA, HSP90AB1, LEF1, RIPK1, BIRC3, BCL2, FLNB, DCTN2, TUBB3, TUBB2CMore
Ixabepilonehsa05140Leishmaniasis4.05E-036P14598, P42224, P25963, P29350, P51617, Q15080NCF1, STAT1, NFKBIA, PTPN6, IRAK1, NCF4More
Ixabepilonehsa05145Toxoplasmosis1.95E-026P51617, P25963, P10415, Q13489, P42224, P11142IRAK1, NFKBIA, BCL2, BIRC3, STAT1, HSPA8More
Ixabepilonehsa05152Tuberculosis6.22E-048Q13488, P0DP23, P42224, P25208, P10415, P01568, Q9UDY8, P51617TCIRG1, CALM1, STAT1, NFYB, BCL2, IFNA21, MALT1, IRAK1More
Ixabepilonehsa05162Measles4.50E-038P51617, P01568, P25963, P42224, P14784, P10747, P11142, P10415IRAK1, IFNA21, NFKBIA, STAT1, IL2RB, CD28, HSPA8, BCL2More
Ixabepilonehsa05166Human T-cell leukemia virus 1 infection1.77E-028P27824, P30279, P21796, P84022, Q13485, P07766, Q92830, P06746CANX, CCND2, VDAC1, SMAD3, SMAD4, CD3E, KAT2A, POLBMore
Ixabepilonehsa05168Herpes simplex virus 1 infection5.65E-0414P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P51617, Q13398, Q9NR11, P17097, P17038, Q03923, P10415NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, ZNF211, ZNF302, ZNF7, ZNF43, ZNF85, BCL2More
Ixabepilonehsa05170Human immunodeficiency virus 1 infection3.95E-0511P62873, P0DP23, P17252, Q13546, P01568, P51617, P25963, Q13315, P23528, P10415, Q9Y6Q5GNB1, CALM1, PRKCA, RIPK1, IFNA21, IRAK1, NFKBIA, ATM, CFL1, BCL2, AP1M2More
Ixabepilonehsa05200Pathways in cancer2.19E-0527P04628, Q13751, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, P14923, P30279, P10415, Q13489, Q12778, P25116, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784, P01042WNT1, LAMB3, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, JUP, CCND2, BCL2, BIRC3, FOXO1, F2R, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB, KNG1More
Ixabepilonehsa05203Viral carcinogenesis1.90E-026P06746, Q92830, P07948, P30279, P29083, Q93079POLB, KAT2A, LYN, CCND2, GTF2E1, H2BC9More
Ixabepilonehsa05214Glioma2.90E-023P0DP23, Q16566, P17252CALM1, CAMK4, PRKCAMore
Ixabepilonehsa05215Prostate cancer6.15E-035P10415, Q9UJU2, Q12778, Q9NRA1, P08238BCL2, LEF1, FOXO1, PDGFC, HSP90AB1More
Ixabepilonehsa05231Choline metabolism in cancer5.44E-034Q9NRA1, P23743, O14494, P17252PDGFC, DGKA, PLPP1, PRKCAMore

Community members of Ixabepilone (SDC: 1.38)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q13509TUBB3Tubulin betaNone3 chainReported00.09040.09610.64840.8858
Q13885TUBB2ATubulin betaNone2A chainPredicted00.03980.09630.64840.8609
P68371TUBB2CTubulin betaNone4B chainPredicted00.28660.0970.64840.9857
Q71U36TUBA1ATubulin alphaNone1A chainPredicted00.58880.07010.70941.1439
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)