PharmaCoNets of Ivosidenib (SPCN: 1.54 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ivosidenibhsa00220Arginine biosynthesis1.21E-021P15104GLULMore
Ivosidenibhsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Ivosidenibhsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Ivosidenibhsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Ivosidenibhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Ivosidenibhsa00730Thiamine metabolism1.15E-032Q9Y6K8, P24666AK5, ACP1More
Ivosidenibhsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Ivosidenibhsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Ivosidenibhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Ivosidenibhsa01230Biosynthesis of amino acids5.53E-032P15104, P37837GLUL, TALDO1More
Ivosidenibhsa04142Lysosome2.64E-022Q99437, P25774ATP6V0B, CTSSMore
Ivosidenibhsa04145Phagosome3.11E-022Q99437, P25774ATP6V0B, CTSSMore
Ivosidenibhsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Ivosidenibhsa04530Tight junction4.35E-022P63261, Q92974ACTG1, ARHGEF2More
Ivosidenibhsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Ivosidenibhsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Ivosidenibhsa05152Tuberculosis4.16E-022Q99437, P25774ATP6V0B, CTSSMore

Community members of Ivosidenib (SDC: 1.86)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)