PharmaCoNets of Ivermectin (SPCN: 3.30 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ivermectinhsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Ivermectinhsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Ivermectinhsa03050Proteasome1.40E-021P55036PSMD4More
Ivermectinhsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Ivermectinhsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Ivermectinhsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Ivermectinhsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Ivermectinhsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Ivermectinhsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Ivermectinhsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Ivermectinhsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Ivermectinhsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Ivermectinhsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Ivermectinhsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Ivermectinhsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Ivermectinhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Ivermectinhsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Ivermectinhsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Ivermectinhsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Ivermectinhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Ivermectinhsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Ivermectinhsa05163Human cytomegalovirus infection2.09E-024P62873, P61586, P63092, P61769GNB1, RHOA, GNAS, B2MMore
Ivermectinhsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Ivermectinhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Ivermectinhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore

Community members of Ivermectin (SDC: 1.10)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Predicted00.32530.5650.15791.4506
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonPredicted00.13940.40970.15791.0469
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)