PharmaCoNets of Itraconazole (SPCN: 16.55 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Itraconazolehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Itraconazolehsa00500Starch and sucrose metabolism8.19E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Itraconazolehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Itraconazolehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Itraconazolehsa00730Thiamine metabolism7.19E-042P05186, P24666ALPL, ACP1More
Itraconazolehsa00770Pantothenate and CoA biosynthesis7.90E-033O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Itraconazolehsa00970Aminoacyl-tRNA biosynthesis7.90E-033O95363, P54136, Q15046FARS2, RARS1, KARSMore
Itraconazolehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Itraconazolehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Itraconazolehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Itraconazolehsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Itraconazolehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Itraconazolehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Itraconazolehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Itraconazolehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Itraconazolehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Itraconazolehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Itraconazolehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Itraconazolehsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Itraconazolehsa04650Natural killer cell mediated cytotoxicity6.45E-0512P16298, P50591, P01375, P06239, O60880, P20963, Q02750, Q13241, P26718, O75015, P26717, P26715PPP3CB, TNFSF10, TNF, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Itraconazolehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Itraconazolehsa04660T cell receptor signaling pathway2.78E-027P01375, Q08881, P20963, Q13191, P06239, Q16539, P49841TNF, ITK, CD247, CBLB, LCK, MAPK14, GSK3BMore
Itraconazolehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Itraconazolehsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Itraconazolehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Itraconazolehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Itraconazolehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Itraconazolehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Itraconazolehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Itraconazolehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Itraconazolehsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Itraconazolehsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Itraconazolehsa05144Malaria2.07E-024P60033, P01375, P35443, P26718CD81, TNF, THBS4, KLRK1More
Itraconazolehsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Itraconazolehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Itraconazolehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Itraconazolehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Itraconazolehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Itraconazolehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Itraconazolehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Itraconazolehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Itraconazolehsa05418Fluid shear stress and atherosclerosis3.61E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Itraconazole (SDC: 3.51)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P11511CYP19A1AromatasePredicted00.815610.15882.5666
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)