PharmaCoNets of Istradefylline (SPCN: 73.11 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Istradefyllinehsa00030Pentose phosphate pathway1.08E-053P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Istradefyllinehsa00220Arginine biosynthesis1.43E-022P05089, P49448ARG1, GLUD2More
Istradefyllinehsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Istradefyllinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Istradefyllinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Istradefyllinehsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Istradefyllinehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Istradefyllinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Istradefyllinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Istradefyllinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Istradefyllinehsa01230Biosynthesis of amino acids2.22E-034P51854, P60891, Q99707, P37837TKTL1, PRPS1, MTR, TALDO1More
Istradefyllinehsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Istradefyllinehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Istradefyllinehsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Istradefyllinehsa03020RNA polymerase3.00E-023P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Istradefyllinehsa03040Spliceosome1.46E-024P17844, P51991, P61978, P11142DDX5, HNRPA3, HNRPK, HSPA8More
Istradefyllinehsa03050Proteasome4.83E-021P55036PSMD4More
Istradefyllinehsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Istradefyllinehsa03410Base excision repair7.59E-031P27695APEX1More
Istradefyllinehsa04020Calcium signaling pathway4.45E-023P0DP24, P51828, P23634CALM2, ADCY7, ATP2B4More
Istradefyllinehsa04024cAMP signaling pathway3.79E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Istradefyllinehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Istradefyllinehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Istradefyllinehsa04064NF-kappa B signaling pathway1.69E-0311P14778, P01584, P19174, Q04759, P06239, P63279, Q8NHW4, P09341, P19875, Q06643, Q9NQC7IL1R1, IL1B, PLCG1, PRKCQ, LCK, UBE2I, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Istradefyllinehsa04071Sphingolipid signaling pathway6.91E-046P21453, Q9H228, P01375, Q13510, Q13362, Q9UQC2S1PR1, EDG8, TNF, ASAH1, PPP2R5C, GAB2More
Istradefyllinehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Istradefyllinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Istradefyllinehsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Istradefyllinehsa04114Oocyte meiosis8.69E-034P0DP24, P51828, P27348, Q13362CALM2, ADCY7, YWHAQ, PPP2R5CMore
Istradefyllinehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Istradefyllinehsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Istradefyllinehsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Istradefyllinehsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Istradefyllinehsa04151PI3K-Akt signaling pathway3.91E-037P62753, P27348, P07900, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGKMore
Istradefyllinehsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Istradefyllinehsa04213Longevity regulating pathway - multiple species2.70E-037P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Istradefyllinehsa04261Adrenergic signaling in cardiomyocytes4.86E-059P07550, P51828, P22694, Q99941, P18848, Q13362, P0DP24, Q13557, P23634ADRB2, ADCY7, PRKACB, CREBL1, ATF4, PPP2R5C, CALM2, CAMK2D, ATP2B4More
Istradefyllinehsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Istradefyllinehsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Istradefyllinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Istradefyllinehsa04612Antigen processing and presentation1.12E-059P48382, Q14953, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375RFX5, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNFMore
Istradefyllinehsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Istradefyllinehsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Istradefyllinehsa04621NOD-like receptor signaling pathway2.27E-029Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Istradefyllinehsa04623Cytosolic DNA-sensing pathway1.65E-022P01584, Q8NHW4IL1B, CCL4L2More
Istradefyllinehsa04640Hematopoietic cell lineage2.18E-039P14778, P27930, P11215, P25063, P07766, P01732, P01730, P06127, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD4, CD5, CD7More
Istradefyllinehsa04650Natural killer cell mediated cytotoxicity2.86E-1014P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, Q07444, Q14953, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1More
Istradefyllinehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Istradefyllinehsa04658Th1 and Th2 cell differentiation6.40E-0810Q04759, P07766, P20963, P09693, P19174, P06239, P23771, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, GATA3, TBX21, IL2RB, RUNX3More
Istradefyllinehsa04659Th17 cell differentiation1.02E-0510Q04759, P19174, P06239, P14784, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Istradefyllinehsa04660T cell receptor signaling pathway1.19E-0511Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Istradefyllinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Istradefyllinehsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Istradefyllinehsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Istradefyllinehsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Istradefyllinehsa04750Inflammatory mediator regulation of TRP channels7.85E-049P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Istradefyllinehsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Istradefyllinehsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Istradefyllinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Istradefyllinehsa04915Estrogen signaling pathway4.95E-049Q99941, P18848, Q08828, P51828, P07900, P0DMV8, P11142, P0DP23, Q15788CREBL1, ATF4, ADCY1, ADCY7, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1More
Istradefyllinehsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Istradefyllinehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Istradefyllinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Istradefyllinehsa04925Aldosterone synthesis and secretion5.96E-056Q99941, P18848, P51828, P0DP24, Q13557, P23634CREBL1, ATF4, ADCY7, CALM2, CAMK2D, ATP2B4More
Istradefyllinehsa04926Relaxin signaling pathway2.06E-036Q99941, P18848, P22694, P14780, P51828, P30679CREBL1, ATF4, PRKACB, MMP9, ADCY7, GNA15More
Istradefyllinehsa04927Cortisol synthesis and secretion2.72E-044Q99941, P18848, P51828, P22694CREBL1, ATF4, ADCY7, PRKACBMore
Istradefyllinehsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Istradefyllinehsa04932Non-alcoholic fatty liver disease1.39E-026O43521, O75460, P01584, P13073, P12074, O95298BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2More
Istradefyllinehsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Istradefyllinehsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Istradefyllinehsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Istradefyllinehsa04970Salivary secretion3.60E-058P07550, Q08828, P51828, P22694, P23634, P0DP24, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ATP2B4, CALM2, CALM1, CAMPMore
Istradefyllinehsa04972Pancreatic secretion4.94E-033P23634, P51828, P62491ATP2B4, ADCY7, RAB11AMore
Istradefyllinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Istradefyllinehsa04976Bile secretion4.78E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Istradefyllinehsa05016Huntington disease2.46E-029O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12More
Istradefyllinehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Istradefyllinehsa05031Amphetamine addiction8.84E-045Q13557, P22694, Q99941, P18848, Q13547CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Istradefyllinehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Istradefyllinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Istradefyllinehsa05134Legionellosis8.80E-047P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Istradefyllinehsa05144Malaria1.72E-034P60033, P01375, P35443, P26718CD81, TNF, THBS4, KLRK1More
Istradefyllinehsa05146Amoebiasis1.95E-0612P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Istradefyllinehsa05150Staphylococcus aureus infection1.02E-037P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Istradefyllinehsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Istradefyllinehsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Istradefyllinehsa05163Human cytomegalovirus infection3.31E-027P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RAMore
Istradefyllinehsa05203Viral carcinogenesis2.63E-037Q99941, P18848, P27348, Q15283, P61978, P62807, O60814CREBL1, ATF4, YWHAQ, RASA2, HNRPK, HIST1H2BC, H2BC12More
Istradefyllinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Istradefyllinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Istradefyllinehsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Istradefyllinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.32E-048P42338, O95267, P19174, P07766, P20963, P09693, P06239, Q04759PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQMore
Istradefyllinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Istradefyllinehsa05322Systemic lupus erythematosus1.49E-058P08311, P09871, Q93077, P62807, Q16778, O60814, P68431, P12814CTSG, C1S, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1More
Istradefyllinehsa05332Graft-versus-host disease8.79E-033P01375, P26715, Q13241TNF, KLRC1, KLRD1More

Community members of Istradefylline (SDC: 5.72)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)