PharmaCoNets of Isradipine (SPCN: 11.96 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Isradipinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Isradipinehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Isradipinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Isradipinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Isradipinehsa00604Glycosphingolipid biosynthesis - ganglio series1.34E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Isradipinehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Isradipinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Isradipinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Isradipinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Isradipinehsa03050Proteasome4.83E-021P55036PSMD4More
Isradipinehsa04064NF-kappa B signaling pathway4.58E-034Q13489, Q13546, Q9UDY8, Q9UNE0BIRC3, RIPK1, MALT1, EDARMore
Isradipinehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Isradipinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Isradipinehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Isradipinehsa04217Necroptosis2.93E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Isradipinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Isradipinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Isradipinehsa04610Complement and coagulation cascades4.69E-031P0C0L4C4AMore
Isradipinehsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Isradipinehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Isradipinehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Isradipinehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Isradipinehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Isradipinehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Isradipinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Isradipinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Isradipinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Isradipinehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Isradipinehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Isradipinehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Isradipinehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Isradipinehsa05150Staphylococcus aureus infection4.36E-022P0C0L4, P13646C4A, KRT13More
Isradipinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Isradipinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Isradipinehsa05214Glioma4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Isradipinehsa05218Melanoma1.34E-022P09619, Q02750PDGFRB, MAP2K1More
Isradipinehsa05230Central carbon metabolism in cancer4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Isradipinehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More

Community members of Isradipine (SDC: 3.52)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P54284CACNB3VoltageNonedependent LNonetype calcium channel subunit betaNone3Predicted00.10260.15390.32910.6881
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)