PharmaCoNets of Isopropamide (SPCN: 9.22 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Isopropamidehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Isopropamidehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Isopropamidehsa00630Glyoxylate and dicarboxylate metabolism4.46E-032P40925, P15104MDH1, GLULMore
Isopropamidehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Isopropamidehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Isopropamidehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Isopropamidehsa03040Spliceosome2.96E-025O60508, P08579, Q07955, Q01130, Q9Y2W2CDC40, SNRPB2, SFRS1, SFRS2, WBP11More
Isopropamidehsa04014Ras signaling pathway2.54E-025P42338, P20827, P49767, Q13009, P50151PIK3CB, EFNA1, VEGFC, TIAM1, GNG10More
Isopropamidehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Isopropamidehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Isopropamidehsa04151PI3K-Akt signaling pathway1.14E-028P42338, P43657, P20827, P49767, P50151, O15335, Q13751, P14784PIK3CB, P2RY5, EFNA1, VEGFC, GNG10, CHAD, LAMB3, IL2RBMore
Isopropamidehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Isopropamidehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Isopropamidehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Isopropamidehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Isopropamidehsa04662B cell receptor signaling pathway9.78E-045P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Isopropamidehsa04664Fc epsilon RI signaling pathway1.82E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Isopropamidehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Isopropamidehsa04724Glutamatergic synapse3.24E-023P43003, P50151, P15104SLC1A3, GNG10, GLULMore
Isopropamidehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Isopropamidehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Isopropamidehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Isopropamidehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Isopropamidehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Isopropamidehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Isopropamidehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Isopropamidehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Isopropamidehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Isopropamidehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore

Community members of Isopropamide (SDC: 2.67)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P35610SOAT1Sterol ONoneacyltransferase 1Predicted10.38550.29360.01650.7964
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)