PharmaCoNets of Isoprenaline (SPCN: 101.46 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Isoprenalinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Isoprenalinehsa00220Arginine biosynthesis2.33E-022P05089, P49448ARG1, GLUD2More
Isoprenalinehsa00500Starch and sucrose metabolism1.47E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Isoprenalinehsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.01E-021Q14442PIGHMore
Isoprenalinehsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Isoprenalinehsa00730Thiamine metabolism4.07E-022P05186, P24666ALPL, ACP1More
Isoprenalinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Isoprenalinehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Isoprenalinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Isoprenalinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Isoprenalinehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Isoprenalinehsa01522Endocrine resistance2.16E-021P04049RAF1More
Isoprenalinehsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Isoprenalinehsa02010ABC transporters3.01E-021P45844ABCG1More
Isoprenalinehsa03010Ribosome1.53E-058P62753, P62906, P46776, Q07020, P61513, P27635, P62249, P23396RPS6, RPL10A, RPL27A, RPL18, RPL37A, RPL10, RPS16, RPS3More
Isoprenalinehsa03013RNA transport4.49E-025P62826, Q9UBU9, P63279, P68104, Q14232RAN, NXF1, UBE2I, EEF1A1, EIF2B1More
Isoprenalinehsa03020RNA polymerase6.21E-044P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Isoprenalinehsa03040Spliceosome1.46E-024P17844, P51991, P61978, P11142DDX5, HNRPA3, HNRPK, HSPA8More
Isoprenalinehsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Isoprenalinehsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Isoprenalinehsa04014Ras signaling pathway3.65E-021P04049RAF1More
Isoprenalinehsa04015Rap1 signaling pathway2.99E-021P04049RAF1More
Isoprenalinehsa04020Calcium signaling pathway4.83E-024Q08828, P0DP23, P05141, P51828ADCY1, CALM1, SLC25A5, ADCY7More
Isoprenalinehsa04022cGMP-PKG signaling pathway1.31E-037P04049, P18848, P31751, Q08828, P51828, P05141, P0DP23RAF1, ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Isoprenalinehsa04024cAMP signaling pathway1.09E-025Q08828, P51828, P31751, P0DP23, P04049ADCY1, ADCY7, AKT2, CALM1, RAF1More
Isoprenalinehsa04060Cytokine-cytokine receptor interaction8.61E-039P14784, P27930, P14778, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, Q93038IL2RB, IL1R2, IL1R1, IL10RA, IL21R, CXCR1, XCL2, XCL1, TNFRSF25More
Isoprenalinehsa04061Viral protein interaction with cytokine and cytokine receptor2.06E-036Q8NHW4, P25024, P47992, Q9UBD3, Q13651, P14784CCL4L2, CXCR1, XCL1, XCL2, IL10RA, IL2RBMore
Isoprenalinehsa04062Chemokine signaling pathway1.66E-039P25024, P47992, Q9UBD3, P07948, P42338, P63218, P50151, P49407, P04049CXCR1, XCL1, XCL2, LYN, PIK3CB, GNG5, GNG10, ARRB1, RAF1More
Isoprenalinehsa04064NF-kappa B signaling pathway4.85E-0411O00463, P14778, P01584, Q13077, Q16548, Q8WV28, P63279, P24522, Q8NHW4, P09341, Q9NQC7TRAF5, IL1R1, IL1B, TRAF1, BCL2A1, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, CYLDMore
Isoprenalinehsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Isoprenalinehsa04070Phosphatidylinositol signaling system9.86E-034P0DP23, O14986, Q16760, P48426CALM1, PIP5K1B, DGKD, PIP4K2AMore
Isoprenalinehsa04071Sphingolipid signaling pathway3.35E-035P04049, P21453, Q9H228, P01375, Q13362RAF1, S1PR1, EDG8, TNF, PPP2R5CMore
Isoprenalinehsa04072Phospholipase D signaling pathway6.61E-047P04049, P31751, O14986, Q15438, Q08828, P51828, Q16760RAF1, AKT2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Isoprenalinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Isoprenalinehsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Isoprenalinehsa04114Oocyte meiosis1.35E-025P0DP23, Q08828, P51828, Q13362, Q14738CALM1, ADCY1, ADCY7, PPP2R5C, PPP2R5DMore
Isoprenalinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Isoprenalinehsa04140Autophagy - animal4.41E-036P31751, P04049, Q7L523, O75460, Q96GC9, Q8TEV9AKT2, RAF1, RRAGA, ERN1, TMEM49, SMCR8More
Isoprenalinehsa04141Protein processing in endoplasmic reticulum2.82E-048P18848, Q15437, Q15436, Q99941, P11142, P07900, Q9NR31, P14625ATF4, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, SAR1A, HSP90B1More
Isoprenalinehsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Isoprenalinehsa04151PI3K-Akt signaling pathway4.12E-049P62753, P27348, P07900, P14625, Q16363, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, HSP90B1, LAMA4, TNXB, CREBL1, ATF4, SGKMore
Isoprenalinehsa04210Apoptosis2.16E-021P04049RAF1More
Isoprenalinehsa04211Longevity regulating pathway1.32E-035P31751, Q08828, P51828, Q99941, P18848AKT2, ADCY1, ADCY7, CREBL1, ATF4More
Isoprenalinehsa04213Longevity regulating pathway - multiple species4.07E-035P31751, Q9Y4H2, Q08828, P51828, Q13547AKT2, IRS2, ADCY1, ADCY7, HDAC1More
Isoprenalinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Isoprenalinehsa04218Cellular senescence2.49E-021P04049RAF1More
Isoprenalinehsa04261Adrenergic signaling in cardiomyocytes2.54E-0611P07550, Q08828, P51828, P22694, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557ADRB2, ADCY1, ADCY7, PRKACB, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2DMore
Isoprenalinehsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Isoprenalinehsa04340Hedgehog signaling pathway3.01E-021Q9Y496KIF3AMore
Isoprenalinehsa04360Axon guidance2.49E-021P04049RAF1More
Isoprenalinehsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Isoprenalinehsa04371Apelin signaling pathway1.24E-025P31751, P04049, Q08828, P51828, P0DP23AKT2, RAF1, ADCY1, ADCY7, CALM1More
Isoprenalinehsa04380Osteoclast differentiation1.88E-024Q9NQC7, P23458, P31751, P01584CYLD, JAK1, AKT2, IL1BMore
Isoprenalinehsa04510Focal adhesion3.48E-021P04049RAF1More
Isoprenalinehsa04540Gap junction1.33E-021P04049RAF1More
Isoprenalinehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Isoprenalinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Isoprenalinehsa04613Neutrophil extracellular trap formation5.32E-056P04049, P11215, Q13547, P58876, Q16778, O60814RAF1, ITGAM, HDAC1, H2BC5, HIST2H2BE, H2BC12More
Isoprenalinehsa04620Toll-like receptor signaling pathway2.54E-033P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Isoprenalinehsa04623Cytosolic DNA-sensing pathway2.21E-043P01584, Q9Y535, Q8NHW4IL1B, POLR3H, CCL4L2More
Isoprenalinehsa04625C-type lectin receptor signaling pathway1.45E-035P04049, P01584, Q9NQC7, P31751, P0DP23RAF1, IL1B, CYLD, AKT2, CALM1More
Isoprenalinehsa04630JAK-STAT signaling pathway8.73E-034P31751, P23458, Q13651, P04049AKT2, JAK1, IL10RA, RAF1More
Isoprenalinehsa04640Hematopoietic cell lineage2.46E-038P14778, P27930, P25063, P07766, P01732, P01730, P06127, P09564IL1R1, IL1R2, CD24, CD3E, CD8A, CD4, CD5, CD7More
Isoprenalinehsa04650Natural killer cell mediated cytotoxicity2.93E-058P01375, P20963, P04049, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, RAF1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Isoprenalinehsa04657IL-17 signaling pathway3.33E-038O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Isoprenalinehsa04658Th1 and Th2 cell differentiation3.72E-047Q04759, P07766, P20963, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, LCK, TBX21, IL2RB, RUNX3More
Isoprenalinehsa04659Th17 cell differentiation2.58E-048Q04759, P06239, P14784, P14778, Q9HBE5, Q9UL17, P07766, P20963PRKCQ, LCK, IL2RB, IL1R1, IL21R, TBX21, CD3E, CD247More
Isoprenalinehsa04660T cell receptor signaling pathway2.37E-048Q04759, P42338, P07766, P20963, P01732, Q13191, P06239, P04049PRKCQ, PIK3CB, CD3E, CD247, CD8A, CBLB, LCK, RAF1More
Isoprenalinehsa04662B cell receptor signaling pathway2.69E-046P42338, P60033, P07948, P21854, Q8N149, P04049PIK3CB, CD81, LYN, CD72, LILRA2, RAF1More
Isoprenalinehsa04664Fc epsilon RI signaling pathway1.16E-021P04049RAF1More
Isoprenalinehsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Isoprenalinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Isoprenalinehsa04713Circadian entrainment4.54E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Isoprenalinehsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Isoprenalinehsa04720Long-term potentiation1.06E-024P0DP23, P18848, Q08828, P04049CALM1, ATF4, ADCY1, RAF1More
Isoprenalinehsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Isoprenalinehsa04725Cholinergic synapse7.81E-045Q08828, P51828, P18848, Q13557, P31751ADCY1, ADCY7, ATF4, CAMK2D, AKT2More
Isoprenalinehsa04726Serotonergic synapse1.33E-021P04049RAF1More
Isoprenalinehsa04728Dopaminergic synapse1.01E-037P31751, Q99941, P18848, Q13557, Q13362, Q14738, P0DP23AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1More
Isoprenalinehsa04730Long-term depression1.16E-021P04049RAF1More
Isoprenalinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Isoprenalinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Isoprenalinehsa04750Inflammatory mediator regulation of TRP channels4.76E-048P14778, P01584, Q08828, P51828, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PIK3CB, PRKCH, PRKCQ, CALM1More
Isoprenalinehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Isoprenalinehsa04910Insulin signaling pathway1.49E-021P04049RAF1More
Isoprenalinehsa04911Insulin secretion4.09E-055Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Isoprenalinehsa04912GnRH signaling pathway1.65E-046Q08828, P51828, P18848, Q13557, P0DP23, P04049ADCY1, ADCY7, ATF4, CAMK2D, CALM1, RAF1More
Isoprenalinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Isoprenalinehsa04914Progesterone-mediated oocyte maturation2.16E-021P04049RAF1More
Isoprenalinehsa04915Estrogen signaling pathway5.89E-059P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P11142, P0DP23RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA8, CALM1More
Isoprenalinehsa04916Melanogenesis4.54E-034P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Isoprenalinehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Isoprenalinehsa04918Thyroid hormone synthesis1.98E-045P51828, Q99941, P18848, P14625, P02768ADCY7, CREBL1, ATF4, HSP90B1, ALBMore
Isoprenalinehsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Isoprenalinehsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Isoprenalinehsa04923Regulation of lipolysis in adipocytes5.15E-033Q08828, P51828, P31751ADCY1, ADCY7, AKT2More
Isoprenalinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Isoprenalinehsa04925Aldosterone synthesis and secretion5.46E-056Q99941, P18848, Q08828, P51828, P0DP23, Q13557CREBL1, ATF4, ADCY1, ADCY7, CALM1, CAMK2DMore
Isoprenalinehsa04926Relaxin signaling pathway4.78E-059P31751, Q99941, P18848, P22694, P14780, Q08828, P51828, P04049, P30679AKT2, CREBL1, ATF4, PRKACB, MMP9, ADCY1, ADCY7, RAF1, GNA15More
Isoprenalinehsa04927Cortisol synthesis and secretion1.02E-055Q99941, P18848, Q08828, P51828, P22694CREBL1, ATF4, ADCY1, ADCY7, PRKACBMore
Isoprenalinehsa04928Parathyroid hormone synthesis, secretion and action3.95E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Isoprenalinehsa04929GnRH secretion4.98E-031P04049RAF1More
Isoprenalinehsa04932Non-alcoholic fatty liver disease5.87E-048P31751, P01375, P49841, P18848, P48023, O75460, P01584, O95298AKT2, TNF, GSK3B, ATF4, FASLG, ERN1, IL1B, NDUFC2More
Isoprenalinehsa04934Cushing syndrome2.20E-045Q99941, P18848, Q08828, P51828, Q13557CREBL1, ATF4, ADCY1, ADCY7, CAMK2DMore
Isoprenalinehsa04935Growth hormone synthesis, secretion and action3.68E-046Q08828, P51828, P04049, Q99941, P18848, P31751ADCY1, ADCY7, RAF1, CREBL1, ATF4, AKT2More
Isoprenalinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Isoprenalinehsa04970Salivary secretion7.22E-046P07550, Q08828, P51828, P22694, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CAMPMore
Isoprenalinehsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Isoprenalinehsa04976Bile secretion1.59E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Isoprenalinehsa05010Alzheimer disease4.94E-039O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4More
Isoprenalinehsa05016Huntington disease2.24E-027O95298, P24928, P30876, P62487, P05141, O75460, P28070NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Isoprenalinehsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Isoprenalinehsa05022Pathways of neurodegeneration - multiple diseases1.67E-029O95298, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, P28070NDUFC2, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, PSMB4More
Isoprenalinehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Isoprenalinehsa05031Amphetamine addiction8.84E-045Q13557, P22694, Q99941, P18848, Q13547CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Isoprenalinehsa05034Alcoholism1.49E-045Q13547, P04049, P58876, Q16778, O60814HDAC1, RAF1, H2BC5, HIST2H2BE, H2BC12More
Isoprenalinehsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Isoprenalinehsa05132Salmonella infection4.98E-021P04049RAF1More
Isoprenalinehsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Isoprenalinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Isoprenalinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Isoprenalinehsa05146Amoebiasis3.65E-0512P09341, P19875, P14778, P27930, P01375, O60603, P42338, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Isoprenalinehsa05152Tuberculosis3.98E-021P04049RAF1More
Isoprenalinehsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Isoprenalinehsa05161Hepatitis B5.33E-034P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Isoprenalinehsa05163Human cytomegalovirus infection4.86E-0517P31751, P04049, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463AKT2, RAF1, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5More
Isoprenalinehsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Isoprenalinehsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Isoprenalinehsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-021P04049RAF1More
Isoprenalinehsa05170Human immunodeficiency virus 1 infection3.48E-021P04049RAF1More
Isoprenalinehsa05171Coronavirus disease - COVID-194.36E-058P23396, P62753, P62249, P62906, P27635, Q07020, P46776, P61513RPS3, RPS6, RPS16, RPL10A, RPL10, RPL18, RPL27A, RPL37AMore
Isoprenalinehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Isoprenalinehsa05203Viral carcinogenesis5.38E-048Q99941, P18848, P27348, Q13547, P61978, P58876, Q16778, O60814CREBL1, ATF4, YWHAQ, HDAC1, HNRPK, H2BC5, HIST2H2BE, H2BC12More
Isoprenalinehsa05205Proteoglycans in cancer1.09E-026P04049, P14780, P01375, P23588, Q13635, P22694RAF1, MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Isoprenalinehsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Isoprenalinehsa05210Colorectal cancer1.66E-021P04049RAF1More
Isoprenalinehsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Isoprenalinehsa05212Pancreatic cancer3.52E-034P31751, P04049, Q15311, P23458AKT2, RAF1, RALBP1, JAK1More
Isoprenalinehsa05213Endometrial cancer9.95E-031P04049RAF1More
Isoprenalinehsa05214Glioma9.95E-031P04049RAF1More
Isoprenalinehsa05215Prostate cancer3.72E-033P18848, P14625, P04049ATF4, HSP90B1, RAF1More
Isoprenalinehsa05218Melanoma6.63E-031P04049RAF1More
Isoprenalinehsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Isoprenalinehsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Isoprenalinehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Isoprenalinehsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Isoprenalinehsa05224Breast cancer1.24E-025P04049, P49841, Q92837, P04637, P24522RAF1, GSK3B, FRAT1, TP53, GADD45AMore
Isoprenalinehsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Isoprenalinehsa05226Gastric cancer8.29E-031P04049RAF1More
Isoprenalinehsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Isoprenalinehsa05231Choline metabolism in cancer5.74E-034P04049, P31751, Q16760, O14986RAF1, AKT2, DGKD, PIP5K1BMore
Isoprenalinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.57E-0411P42338, O95267, P07766, P20963, P09693, P06239, P04049, O60603, Q04759, Q16539, P01730PIK3CB, RASGRP1, CD3E, CD247, CD3G, LCK, RAF1, TLR2, PRKCQ, MAPK14, CD4More
Isoprenalinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Isoprenalinehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Isoprenalinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Isoprenalinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Isoprenalinehsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Isoprenaline (SDC: 4.32)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
P00441SOD1Superoxide dismutase [CuNoneZn]Reported10.53850.07130.48710.8991
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P14625HSP90B1EndoplasminPredicted00.23360.14970.53840.9546
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
Q15131CDK10CyclinNonedependent kinase 10Predicted00.36120.032300.2453
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
ADRB2P07550Ki2.4
ADRB2P07550Ki46
ADRB2P07550Ki136
ADRB2P07550Kd50
ADRB2P07550Kd251