PharmaCoNets of Isoniazid (SPCN: 9.03 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Isoniazidhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Isoniazidhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Isoniazidhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Isoniazidhsa00670One carbon pool by folate3.62E-021P00374DHFRMore
Isoniazidhsa00790Folate biosynthesis3.62E-021P00374DHFRMore
Isoniazidhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Isoniazidhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Isoniazidhsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Isoniazidhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Isoniazidhsa03015mRNA surveillance pathway4.42E-024O60942, O43148, P52298, Q53GS7RNGTT, RNMT, NCBP2, GLE1More
Isoniazidhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Isoniazidhsa04064NF-kappa B signaling pathway1.60E-028P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Isoniazidhsa04071Sphingolipid signaling pathway2.96E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Isoniazidhsa04080Neuroactive ligand-receptor interaction3.22E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1More
Isoniazidhsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Isoniazidhsa04145Phagosome2.61E-025P63261, Q15080, P14598, Q13509, P68371ACTG1, NCF4, NCF1, TUBB3, TUBB2CMore
Isoniazidhsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Isoniazidhsa04217Necroptosis5.89E-037P01568, Q13489, Q13546, P07384, Q6FI13, P10415, O43633IFNA21, BIRC3, RIPK1, CAPN1, H2AC18; H2AC19, BCL2, CHMP2AMore
Isoniazidhsa04510Focal adhesion4.64E-026O75369, Q15942, Q13489, P10415, P49767, P63261FLNB, ZYX, BIRC3, BCL2, VEGFC, ACTG1More
Isoniazidhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Isoniazidhsa04612Antigen processing and presentation3.21E-026P13765, P48382, P26715, P26717, Q13241, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8AMore
Isoniazidhsa04613Neutrophil extracellular trap formation2.18E-037P04908, Q93077, P62807, O60814, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Isoniazidhsa04623Cytosolic DNA-sensing pathway2.46E-022P01568, Q13546IFNA21, RIPK1More
Isoniazidhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Isoniazidhsa04725Cholinergic synapse4.83E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Isoniazidhsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Isoniazidhsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Isoniazidhsa04927Cortisol synthesis and secretion8.60E-033Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Isoniazidhsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Isoniazidhsa04932Non-alcoholic fatty liver disease3.62E-023P49841, Q16718, O14521GSK3B, NDUFA5, SDHDMore
Isoniazidhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Isoniazidhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Isoniazidhsa05022Pathways of neurodegeneration - multiple diseases1.25E-0313O15399, Q13509, P68371, P49841, P10415, Q16718, O14521, Q13561, Q16539, P07384, P04628, Q08752, P0DP23GRIN2D, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, DCTN2, MAPK14, CAPN1, WNT1, PPID, CALM1More
Isoniazidhsa05034Alcoholism1.68E-046P62879, Q9BTM1, Q93077, P62807, O60814, P68431GNB2, H2AFJ, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Isoniazidhsa05132Salmonella infection6.88E-038P63261, Q13546, Q13489, P10415, O75369, Q13561, Q13509, P68371ACTG1, RIPK1, BIRC3, BCL2, FLNB, DCTN2, TUBB3, TUBB2CMore
Isoniazidhsa05168Herpes simplex virus 1 infection1.17E-0210Q9UKJ0, Q06124, P01568, Q01130, Q13489, Q13398, Q9NR11, Q03923, Q9UDV6, P10415PILRB, PTPN11, IFNA21, SFRS2, BIRC3, ZNF211, ZNF302, ZNF85, ZNF212, BCL2More
Isoniazidhsa05200Pathways in cancer4.70E-023P17301, P20585, P62879ITGA2, MSH3, GNB2More
Isoniazidhsa05202Transcriptional misregulation in cancer1.77E-0211Q15532, Q13315, P14780, Q15744, Q16548, O15550, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, MMP9, CEBPE, BCL2A1, UTX, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Isoniazidhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Isoniazidhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Isoniazidhsa05321Inflammatory bowel disease2.29E-024P13765, Q14765, P23771, Q9HBE5HLA-DOB, STAT4, GATA3, IL21RMore
Isoniazidhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Isoniazidhsa05332Graft-versus-host disease7.89E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Isoniazidhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Isoniazid (SDC: 1.81)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P33260CYP2C18Cytochrome P450 2C18Predicted10.02390.07560.15280.316
P00374DHFRDihydrofolate reductasePredicted00.3380.18680.22630.7688
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)