PharmaCoNets of Isoflurophate (SPCN: 2.14 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Isoflurophatehsa00830Retinol metabolism3.49E-021P00325ADH1BMore
Isoflurophatehsa00920Sulfur metabolism1.78E-021Q16762TSTMore
Isoflurophatehsa01522Endocrine resistance3.67E-025P14780, P22694, Q9UM47, P46527, P10415MMP9, PRKACB, NOTCH3, CDKN1B, BCL2More
Isoflurophatehsa03013RNA transport4.56E-029P52298, Q09161, O14893, P37198, P35658, Q14152, O75822, Q9Y6A5, Q06787NCBP2, NCBP1, GEMIN2, NUP62, NUP214, EIF3A, EIF3J, TACC3, FMR1More
Isoflurophatehsa03015mRNA surveillance pathway3.71E-026O43148, Q13362, O94913, Q12996, Q09161, P52298RNMT, PPP2R5C, PCF11, CSTF3, NCBP1, NCBP2More
Isoflurophatehsa04014Ras signaling pathway4.65E-023Q15311, P0DP23, P17612RALBP1, CALM1, PRKACAMore
Isoflurophatehsa04114Oocyte meiosis2.15E-023P0DP23, P17612, Q13362CALM1, PRKACA, PPP2R5CMore
Isoflurophatehsa04122Sulfur relay system1.78E-021Q16762TSTMore
Isoflurophatehsa04136Autophagy - other3.53E-021O94817ATG12More
Isoflurophatehsa04137Mitophagy - animal3.24E-024Q96CV9, Q9H1Y0, P18848, O43524OPTN, ATG5, ATF4, FOXO3More
Isoflurophatehsa04144Endocytosis4.07E-035Q9H444, O75351, P42566, Q15438, Q14161CHMP4B, VPS4B, EPS15, PSCD1, GIT2More
Isoflurophatehsa04217Necroptosis4.56E-034P23458, Q9NQC7, Q9H444, O75351JAK1, CYLD, CHMP4B, VPS4BMore
Isoflurophatehsa04261Adrenergic signaling in cardiomyocytes2.50E-023P17612, Q13362, P0DP23PRKACA, PPP2R5C, CALM1More
Isoflurophatehsa04514Cell adhesion molecules2.37E-022P16109, O00501SELP, CLDN5More
Isoflurophatehsa04530Tight junction3.82E-022O00501, P24844CLDN5, MYL9More
Isoflurophatehsa04613Neutrophil extracellular trap formation2.76E-0210O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P49913, O75015, P21462TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, CAMP, FCGR3B, FPR1More
Isoflurophatehsa04621NOD-like receptor signaling pathway7.61E-0310P25963, Q9H1Y0, O00463, P10415, Q05823, P01375, P49913, P59665, P59666, P12838NFKBIA, ATG5, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Isoflurophatehsa04657IL-17 signaling pathway1.53E-026P25963, O00463, P14780, P80188, P01375, P06702NFKBIA, TRAF5, MMP9, LCN2, TNF, S100A9More
Isoflurophatehsa04713Circadian entrainment4.42E-022P0DP23, P17612CALM1, PRKACAMore
Isoflurophatehsa04720Long-term potentiation4.42E-022P0DP23, P17612CALM1, PRKACAMore
Isoflurophatehsa04728Dopaminergic synapse1.55E-023P17612, Q13362, P0DP23PRKACA, PPP2R5C, CALM1More
Isoflurophatehsa04740Olfactory transduction6.71E-032P0DP23, P17612CALM1, PRKACAMore
Isoflurophatehsa04910Insulin signaling pathway3.62E-022P0DP23, P17612CALM1, PRKACAMore
Isoflurophatehsa04916Melanogenesis2.87E-022P17612, P0DP23PRKACA, CALM1More
Isoflurophatehsa04921Oxytocin signaling pathway1.84E-023P0DP23, P17612, Q96RR4CALM1, PRKACA, CAMKK2More
Isoflurophatehsa04924Renin secretion1.09E-022P17612, P0DP23PRKACA, CALM1More
Isoflurophatehsa04970Salivary secretion2.20E-022P17612, P0DP23PRKACA, CALM1More
Isoflurophatehsa04971Gastric acid secretion2.87E-022P17612, P0DP23PRKACA, CALM1More
Isoflurophatehsa04976Bile secretion2.20E-022P17612, Q14032PRKACA, BAATMore
Isoflurophatehsa05031Amphetamine addiction2.87E-022P0DP23, P17612CALM1, PRKACAMore
Isoflurophatehsa05034Alcoholism1.29E-023P17612, P0DP23, Q96RR4PRKACA, CALM1, CAMKK2More
Isoflurophatehsa05140Leishmaniasis2.04E-027O75015, P14598, O60603, P25963, P01375, P29350, Q15080FCGR3B, NCF1, TLR2, NFKBIA, TNF, PTPN6, NCF4More
Isoflurophatehsa05150Staphylococcus aureus infection3.71E-026P21462, O75015, P59665, P59666, P12838, P49913FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Isoflurophatehsa05152Tuberculosis3.04E-029Q13488, O75015, P48382, P25208, O60603, P01375, P10415, P49913, Q9UDY8TCIRG1, FCGR3B, RFX5, NFYB, TLR2, TNF, BCL2, CAMP, MALT1More
Isoflurophatehsa05202Transcriptional misregulation in cancer8.78E-0310Q13315, P14780, P46527, P35226, O60583, P05164, P59665, P59666, P12838, P08246ATM, MMP9, CDKN1B, BMI1, CCNT2, MPO, DEFA1; DEFA1B, DEFA3, DEFA4, ELA2More
Isoflurophatehsa05212Pancreatic cancer2.87E-022Q15311, P23458RALBP1, JAK1More

Community members of Isoflurophate (SDC: 0.49)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P10619CTSALysosomal protective proteinPredicted00.12260.15310.19010.5575
P02788LTFLactotransferrinPredicted10.48660.052100.3474
Q8NFZ4NLGN2NeuroliginNone2Predicted00.5660.06920.16270.5841
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)