PharmaCoNets of Isoflurane (SPCN: 33.22 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Isofluranehsa00061Fatty acid biosynthesis4.83E-021P33121ACSL1More
Isofluranehsa00190Oxidative phosphorylation3.50E-022Q16718, Q13488NDUFA5, TCIRG1More
Isofluranehsa00230Purine metabolism4.60E-024Q13370, P36959, Q13956, P27707PDE3B, GMPR, PDE6H, DCKMore
Isofluranehsa00240Pyrimidine metabolism4.50E-022P32320, P27707CDA, DCKMore
Isofluranehsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Isofluranehsa00500Starch and sucrose metabolism2.86E-022O43451, P46976MGAM, GYG1More
Isofluranehsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin4.77E-021Q7LGA3HS2ST1More
Isofluranehsa00600Sphingolipid metabolism3.01E-022Q9BX95, P06280SGPP1, GLAMore
Isofluranehsa00620Pyruvate metabolism4.20E-022P40926, P14550MDH2, AKR1A1More
Isofluranehsa00670One carbon pool by folate3.99E-022O95954, Q99707FTCD, MTRMore
Isofluranehsa00730Thiamine metabolism1.75E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Isofluranehsa00770Pantothenate and CoA biosynthesis1.78E-022O95498, O95497VNN2, VNN1More
Isofluranehsa00920Sulfur metabolism3.01E-021O95571ETHE1More
Isofluranehsa01100Metabolic pathways6.77E-0332Q9Y234, P15144, Q99707, P29218, P11310, P27707, P32320, Q13370, P36959, Q13956, P06280, P30043, P24666, Q02252, O60701, O14772, O95954, P33121, Q02318, P42330, P04406, Q13093, Q9NY28, O15466, Q9BX95, P09960, Q9P2R7, Q9UHY7, P35573, Q13488, Q16718, Q02809LIPT1, ANPEP, MTR, IMPA1, ACADM, DCK, CDA, PDE3B, GMPR, PDE6H, GLA, BLVRB, ACP1, ALDH6A1, UGDH, FPGT, FTCD, ACSL1, CYP27A1, AKR1C3, GAPDH, PLA2G7, GALNT8, ST8SIA5, SGPP1, LTA4H, SUCLA2, ENOPH1, AGL, TCIRG1, NDUFA5, PLOD1More
Isofluranehsa01240Biosynthesis of cofactors3.34E-023P05186, Q9Y6K8, O75911ALPL, AK5, DHRS3More
Isofluranehsa01524Platinum drug resistance4.45E-024P10415, Q13489, P78417, P43246BCL2, BIRC3, GSTO1, MSH2More
Isofluranehsa02010ABC transporters4.89E-021Q99758ABCA3More
Isofluranehsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Isofluranehsa03010Ribosome3.56E-0614P62753, P42677, P32969, P40429, P62917, P46776, Q9H0U6, Q07020, P62910, Q02878, P36578, P05386, P62249, P23396RPS6, RPS27, RPL9, RPL13A, RPL8, RPL27A, MRPL18, RPL18, RPL32, RPL6, RPL4, RPLP1, RPS16, RPS3More
Isofluranehsa03013RNA transport4.79E-022P62826, P63279RAN, UBE2IMore
Isofluranehsa03015mRNA surveillance pathway3.62E-023O43148, P61326, P52298RNMT, MAGOH, NCBP2More
Isofluranehsa03020RNA polymerase9.86E-072Q9GZM3, P52435POLR2J2, POLR2JMore
Isofluranehsa03040Spliceosome1.11E-0718Q14562, O43143, O60508, P17844, O14776, P08579, O75940, P52298, P09651, Q15365, O75494, Q07955, Q01130, Q13243, P11142, O95777, O43447, P61326DHX8, DHX15, CDC40, DDX5, TCERG1, SNRPB2, SMNDC1, NCBP2, HNRNPA1, PCBP1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, LSM8, PPIH, MAGOHMore
Isofluranehsa03050Proteasome2.10E-043P55036, P43686, P28070PSMD4, PSMC4, PSMB4More
Isofluranehsa03320PPAR signaling pathway2.18E-022O00767, Q02318SCD, CYP27A1More
Isofluranehsa03460Fanconi anemia pathway3.70E-033Q9NPI8, O60673, Q9UNA4FANCF, REV3L, POLIMore
Isofluranehsa04014Ras signaling pathway2.65E-039P31751, P20827, P49767, Q13009, P17252, Q15311, P0DP23, P62873, P19174AKT2, EFNA1, VEGFC, TIAM1, PRKCA, RALBP1, CALM1, GNB1, PLCG1More
Isofluranehsa04015Rap1 signaling pathway5.41E-039P20827, P49767, Q13009, Q08828, P51828, P31751, P0DP23, P17252, P19174EFNA1, VEGFC, TIAM1, ADCY1, ADCY7, AKT2, CALM1, PRKCA, PLCG1More
Isofluranehsa04020Calcium signaling pathway1.04E-0611P27987, Q08828, Q13557, P17252, O15399, P19174, P61073, P0DP23, P51828, P23634, P49767ITPKB, ADCY1, CAMK2D, PRKCA, GRIN2D, PLCG1, CXCR4, CALM1, ADCY7, ATP2B4, VEGFCMore
Isofluranehsa04024cAMP signaling pathway4.61E-0516P49019, P63092, Q08828, P51828, P22694, P31751, P26678, P0DP23, P20020, P23634, P61586, Q13557, Q13370, P48058, O15399, Q13009HCAR3, GNAS, ADCY1, ADCY7, PRKACB, AKT2, PLN, CALM1, ATP2B1, ATP2B4, RHOA, CAMK2D, PDE3B, GRIA4, GRIN2D, TIAM1More
Isofluranehsa04062Chemokine signaling pathway2.04E-0210P51684, Q8NHW4, P19174, P62873, Q08828, P51828, Q13009, P14598, P42224, P31751CCR6, CCL4L2, PLCG1, GNB1, ADCY1, ADCY7, TIAM1, NCF1, STAT1, AKT2More
Isofluranehsa04064NF-kappa B signaling pathway2.28E-049P10415, Q13489, P51617, P01584, P29965, P19174, O75293, Q8NHW4, Q9NQC7BCL2, BIRC3, IRAK1, IL1B, CD40LG, PLCG1, GADD45B, CCL4L2, CYLDMore
Isofluranehsa04070Phosphatidylinositol signaling system5.66E-046P19174, P0DP23, P23743, P48426, P27987, P17252PLCG1, CALM1, DGKA, PIP4K2A, ITPKB, PRKCAMore
Isofluranehsa04071Sphingolipid signaling pathway3.36E-026P17252, Q13510, Q13362, P10415, Q9UQC2, P01042PRKCA, ASAH1, PPP2R5C, BCL2, GAB2, KNG1More
Isofluranehsa04072Phospholipase D signaling pathway2.69E-0311P31751, P61586, P19174, P17252, O14986, Q15438, P63092, Q08828, P51828, P23743, P00734AKT2, RHOA, PLCG1, PRKCA, PIP5K1B, PSCD1, GNAS, ADCY1, ADCY7, DGKA, F2More
Isofluranehsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Isofluranehsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Isofluranehsa04140Autophagy - animal2.58E-027P31751, Q7L523, Q96RR4, O75460, P10415, Q96GC9, Q8TEV9AKT2, RRAGA, CAMKK2, ERN1, BCL2, TMEM49, SMCR8More
Isofluranehsa04144Endocytosis8.99E-0312P11142, Q9H444, O43633, O75351, Q9NZZ3, Q15438, Q14161, P14784, Q96QK1, Q9UMY4, Q9Y5X3, Q9UNH7HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, PSCD1, GIT2, IL2RB, VPS35, SNX12, SNX5, SNX6More
Isofluranehsa04145Phagosome4.88E-049P60709, P63261, Q15075, Q15080, P14598, Q13509, P68371, Q13488, O60603ACTB, ACTG1, EEA1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2More
Isofluranehsa04151PI3K-Akt signaling pathway4.68E-0318O43521, P27348, P20827, P49767, Q13362, P08238, P62873, P16144, P48551, P14784, P23458, P01568, P15336, P18848, P10415, P17252, Q16513, Q6ZUJ8BCL2L11, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AB1, GNB1, ITGB4, IFNAR2, IL2RB, JAK1, IFNA21, ATF2, ATF4, BCL2, PRKCA, PKN2, PIK3AP1More
Isofluranehsa04210Apoptosis6.18E-033P07384, P60709, P63261CAPN1, ACTB, ACTG1More
Isofluranehsa04217Necroptosis2.10E-0916P01568, P23458, Q13489, Q9NQC7, P42224, P08238, P01584, P0C0S5, Q6FI13, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351, Q08752IFNA21, JAK1, BIRC3, CYLD, STAT1, HSP90AB1, IL1B, H2AFZ, H2AC18; H2AC19, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4B, PPIDMore
Isofluranehsa04261Adrenergic signaling in cardiomyocytes4.43E-0611P09493, Q08828, P51828, P31751, P18848, Q13362, P0DP23, Q13557, P17252, P10415, P23634TPM1, ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4More
Isofluranehsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Isofluranehsa04360Axon guidance8.44E-048P61073, P16333, P20827, O95631, P17252, Q13557, P23528, P19174CXCR4, NCK1, EFNA1, NTN1, PRKCA, CAMK2D, CFL1, PLCG1More
Isofluranehsa04371Apelin signaling pathway3.08E-027P62873, P31751, Q08828, P51828, Q13370, Q13485, P0DP23GNB1, AKT2, ADCY1, ADCY7, PDE3B, SMAD4, CALM1More
Isofluranehsa04380Osteoclast differentiation4.18E-027Q9NQC7, Q9UQC2, P23458, P42224, P01584, Q15080, P14598CYLD, GAB2, JAK1, STAT1, IL1B, NCF4, NCF1More
Isofluranehsa04390Hippo signaling pathway2.80E-022P60709, P63261ACTB, ACTG1More
Isofluranehsa04510Focal adhesion5.43E-0310P16144, O75369, Q15942, O14986, P17252, P61586, Q16363, Q13489, P10415, P49767ITGB4, FLNB, ZYX, PIP5K1B, PRKCA, RHOA, LAMA4, BIRC3, BCL2, VEGFCMore
Isofluranehsa04520Adherens junction8.17E-055P19784, P67870, P61586, P60709, P63261CSNK2A2, CSNK2B, RHOA, ACTB, ACTG1More
Isofluranehsa04530Tight junction3.88E-033P60709, P63261, P60660ACTB, ACTG1, MYL6More
Isofluranehsa04540Gap junction4.08E-025P17252, Q13509, P68371, Q08828, P51828PRKCA, TUBB3, TUBB2C, ADCY1, ADCY7More
Isofluranehsa04611Platelet activation2.61E-022P60709, P63261ACTB, ACTG1More
Isofluranehsa04620Toll-like receptor signaling pathway1.33E-025P51617, P01568, P31751, P42224, Q8NHW4IRAK1, IFNA21, AKT2, STAT1, CCL4L2More
Isofluranehsa04621NOD-like receptor signaling pathway5.84E-0313P01584, P08238, P23458, P42224, P01568, Q9H3M7, Q13489, P43490, P10415, P01375, P59665, P59666, P12838IL1B, HSP90AB1, JAK1, STAT1, IFNA21, TXNIP, BIRC3, PBEF1, BCL2, TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Isofluranehsa04623Cytosolic DNA-sensing pathway4.25E-022P01568, Q8NHW4IFNA21, CCL4L2More
Isofluranehsa04630JAK-STAT signaling pathway1.16E-028P31751, P10415, P42224, P23458, P14784, P16871, Q13651, P01568AKT2, BCL2, STAT1, JAK1, IL2RB, IL7R, IL10RA, IFNA21More
Isofluranehsa04640Hematopoietic cell lineage6.17E-047P08514, P21926, P14778, P07766, P01730, P09564, P13765ITGA2B, CD9, IL1R1, CD3E, CD4, CD7, HLA-DOBMore
Isofluranehsa04650Natural killer cell mediated cytotoxicity2.11E-024P17252, O60880, P26717, P26715PRKCA, SH2D1A, KLRC2, KLRC1More
Isofluranehsa04659Th17 cell differentiation2.73E-024Q16539, P01730, P13765, P14778MAPK14, CD4, HLA-DOB, IL1R1More
Isofluranehsa04662B cell receptor signaling pathway3.68E-022P25963, P20023NFKBIA, CR2More
Isofluranehsa04666Fc gamma R-mediated phagocytosis2.78E-026P08575, P19174, P23528, Q9UQC2, P14598, P17252PTPRC, PLCG1, CFL1, GAB2, NCF1, PRKCAMore
Isofluranehsa04670Leukocyte transendothelial migration4.07E-022P60709, P63261ACTB, ACTG1More
Isofluranehsa04713Circadian entrainment7.13E-0710O15399, P0DP23, Q13557, P17252, P62873, P48058, Q08828, P51828, P22694, P63092GRIN2D, CALM1, CAMK2D, PRKCA, GNB1, GRIA4, ADCY1, ADCY7, PRKACB, GNASMore
Isofluranehsa04714Thermogenesis2.20E-047P22694, P15336, P60709, P63261, P33121, Q16718, P36542PRKACB, ATF2, ACTB, ACTG1, ACSL1, NDUFA5, ATP5C1More
Isofluranehsa04720Long-term potentiation3.26E-036P17252, Q13557, P0DP23, P18848, O15399, Q08828PRKCA, CAMK2D, CALM1, ATF4, GRIN2D, ADCY1More
Isofluranehsa04721Synaptic vesicle cycle1.14E-022Q13488, P31645TCIRG1, SLC6A4More
Isofluranehsa04723Retrograde endocannabinoid signaling1.47E-046P17252, P48169, P62873, P48058, P22694, Q16718PRKCA, GABRA4, GNB1, GRIA4, PRKACB, NDUFA5More
Isofluranehsa04724Glutamatergic synapse3.72E-059P48058, O15399, Q08828, P51828, P63092, P22694, P17252, P62873, P15104GRIA4, GRIN2D, ADCY1, ADCY7, GNAS, PRKACB, PRKCA, GNB1, GLULMore
Isofluranehsa04725Cholinergic synapse4.42E-048Q08828, P51828, P17252, P62873, P18848, Q13557, P31751, P10415ADCY1, ADCY7, PRKCA, GNB1, ATF4, CAMK2D, AKT2, BCL2More
Isofluranehsa04726Serotonergic synapse1.84E-035P63092, P22694, P17252, P31645, P62873GNAS, PRKACB, PRKCA, SLC6A4, GNB1More
Isofluranehsa04727GABAergic synapse4.08E-025Q08828, P51828, P62873, P46459, P17252ADCY1, ADCY7, GNB1, NSF, PRKCAMore
Isofluranehsa04740Olfactory transduction2.61E-023P62873, Q13557, P0DP23GNB1, CAMK2D, CALM1More
Isofluranehsa04744Phototransduction1.30E-052P62873, P0DP23GNB1, CALM1More
Isofluranehsa04750Inflammatory mediator regulation of TRP channels4.32E-058P01584, Q08828, P51828, Q13557, P19174, P17252, P0DP23, P01042IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PRKCA, CALM1, KNG1More
Isofluranehsa04911Insulin secretion3.01E-035Q08828, P22694, P17252, P18848, Q13557ADCY1, PRKACB, PRKCA, ATF4, CAMK2DMore
Isofluranehsa04912GnRH signaling pathway2.85E-025P17252, Q08828, P18848, Q13557, P0DP23PRKCA, ADCY1, ATF4, CAMK2D, CALM1More
Isofluranehsa04913Ovarian steroidogenesis1.28E-022P42330, P22694AKR1C3, PRKACBMore
Isofluranehsa04914Progesterone-mediated oocyte maturation3.26E-026Q08828, P51828, P31751, Q13370, Q9UJX4, P08238ADCY1, ADCY7, AKT2, PDE3B, ANAPC5, HSP90AB1More
Isofluranehsa04915Estrogen signaling pathway3.28E-039P18848, Q08828, P51828, P31751, P08238, P11142, P0DP23, Q15788, P10415ATF4, ADCY1, ADCY7, AKT2, HSP90AB1, HSPA8, CALM1, NCOA1, BCL2More
Isofluranehsa04918Thyroid hormone synthesis3.01E-022P22694, P17252PRKACB, PRKCAMore
Isofluranehsa04919Thyroid hormone signaling pathway3.20E-022P60709, P63261ACTB, ACTG1More
Isofluranehsa04921Oxytocin signaling pathway1.77E-033P60660, P60709, P63261MYL6, ACTB, ACTG1More
Isofluranehsa04923Regulation of lipolysis in adipocytes2.12E-024Q08828, P51828, Q13370, P31751ADCY1, ADCY7, PDE3B, AKT2More
Isofluranehsa04925Aldosterone synthesis and secretion3.12E-059P18848, Q08828, P51828, P0DP23, P17252, Q13557, P22694, P20020, P23634ATF4, ADCY1, ADCY7, CALM1, PRKCA, CAMK2D, PRKACB, ATP2B1, ATP2B4More
Isofluranehsa04933AGE-RAGE signaling pathway in diabetic complications2.04E-068Q13485, P01584, P42224, P10415, P31751, P49767, P17252, P19174SMAD4, IL1B, STAT1, BCL2, AKT2, VEGFC, PRKCA, PLCG1More
Isofluranehsa04935Growth hormone synthesis, secretion and action3.93E-026P19174, Q08828, P51828, P17252, P31751, P42224PLCG1, ADCY1, ADCY7, PRKCA, AKT2, STAT1More
Isofluranehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Isofluranehsa04961Endocrine and other factor-regulated calcium reabsorption9.85E-053P20020, P17252, P22694ATP2B1, PRKCA, PRKACBMore
Isofluranehsa04962Vasopressin-regulated water reabsorption6.61E-032P22694, Q13561PRKACB, DCTN2More
Isofluranehsa04970Salivary secretion5.78E-057Q08828, P51828, P22694, P20020, P23634, P17252, P0DP23ADCY1, ADCY7, PRKACB, ATP2B1, ATP2B4, PRKCA, CALM1More
Isofluranehsa04971Gastric acid secretion1.02E-022P60709, P63261ACTB, ACTG1More
Isofluranehsa04972Pancreatic secretion1.74E-068P20020, P23634, P17252, P63092, Q08828, P51828, P62491, P61586ATP2B1, ATP2B4, PRKCA, GNAS, ADCY1, ADCY7, RAB11A, RHOAMore
Isofluranehsa04976Bile secretion3.01E-022P22694, P08183PRKACB, ABCB1More
Isofluranehsa05010Alzheimer disease7.11E-039O15239, P13073, P18848, O15169, P67870, P05141, P12236, P28070, P43686NDUFA1, COX4I1, ATF4, AXIN1, CSNK2B, SLC25A5, SLC25A6, PSMB4, PSMC4More
Isofluranehsa05012Parkinson disease2.14E-027O15239, P13073, P05141, P12236, P18848, P28070, P43686NDUFA1, COX4I1, SLC25A5, SLC25A6, ATF4, PSMB4, PSMC4More
Isofluranehsa05014Amyotrophic lateral sclerosis2.98E-023P36542, P60709, P63261ATP5C1, ACTB, ACTG1More
Isofluranehsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Isofluranehsa05017Spinocerebellar ataxia4.93E-0410P17252, O75460, Q8TB72, O15399, P31751, P28070, P43686, O00232, P05141, P12236PRKCA, ERN1, PUM2, GRIN2D, AKT2, PSMB4, PSMC4, PSMD12, SLC25A5, SLC25A6More
Isofluranehsa05020Prion disease1.55E-0310P46531, O15239, P13073, P18848, P05141, P12236, P28070, P43686, P67870, P51636NOTCH1, NDUFA1, COX4I1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, CSNK2B, CAV2More
Isofluranehsa05022Pathways of neurodegeneration - multiple diseases5.20E-0415P67870, O15239, Q16718, P13073, P18848, Q13561, P48058, P05141, P12236, P17252, P20333, O15169, Q08752, P28070, P43686CSNK2B, NDUFA1, NDUFA5, COX4I1, ATF4, DCTN2, GRIA4, SLC25A5, SLC25A6, PRKCA, TNFRSF1B, AXIN1, PPID, PSMB4, PSMC4More
Isofluranehsa05031Amphetamine addiction2.07E-037O15399, P48058, P0DP23, Q13557, P22694, P18848, P17252GRIN2D, GRIA4, CALM1, CAMK2D, PRKACB, ATF4, PRKCAMore
Isofluranehsa05032Morphine addiction1.20E-049Q08828, P51828, P62873, Q13370, P48169, P78334, P63092, P17252, P32298ADCY1, ADCY7, GNB1, PDE3B, GABRA4, GABRE, GNAS, PRKCA, GRK4More
Isofluranehsa05100Bacterial invasion of epithelial cells8.79E-043P60709, P63261, Q92529ACTB, ACTG1, SHC3More
Isofluranehsa05110Vibrio cholerae infection4.61E-044P17252, P22694, P60709, P63261PRKCA, PRKACB, ACTB, ACTG1More
Isofluranehsa05131Shigellosis1.91E-023P60709, P63261, P07384ACTB, ACTG1, CAPN1More
Isofluranehsa05132Salmonella infection3.99E-0413P51617, P01584, P08238, Q96RF0, Q13489, P10415, P08575, O75369, Q13561, Q13509, P68371, P49754, Q9NP90IRAK1, IL1B, HSP90AB1, SNAG1, BIRC3, BCL2, PTPRC, FLNB, DCTN2, TUBB3, TUBB2C, VPS41, RAB9BMore
Isofluranehsa05133Pertussis3.94E-045P0DP23, P01584, P23528, P09871, P51617CALM1, IL1B, CFL1, C1S, IRAK1More
Isofluranehsa05135Yersinia infection3.88E-033P60709, P63261, Q16513ACTB, ACTG1, PKN2More
Isofluranehsa05140Leishmaniasis2.58E-025P14598, O60603, P25963, P29350, Q15080NCF1, TLR2, NFKBIA, PTPN6, NCF4More
Isofluranehsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Isofluranehsa05143African trypanosomiasis3.56E-035P01375, P01584, P48023, P17252, P01042TNF, IL1B, FASLG, PRKCA, KNG1More
Isofluranehsa05145Toxoplasmosis5.28E-059P51617, P10415, Q13489, P23458, P42224, P31751, P11142, P29965, Q13651IRAK1, BCL2, BIRC3, JAK1, STAT1, AKT2, HSPA8, CD40LG, IL10RAMore
Isofluranehsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Isofluranehsa05161Hepatitis B1.31E-0410P17252, P18848, P23458, Q13485, P31751, P10415, P27348, P01568, P42224, P51617PRKCA, ATF4, JAK1, SMAD4, AKT2, BCL2, YWHAQ, IFNA21, STAT1, IRAK1More
Isofluranehsa05162Measles1.74E-0410P51617, P01568, P23458, P42224, P14784, P31751, P11142, P01584, Q9NP90, P10415IRAK1, IFNA21, JAK1, STAT1, IL2RB, AKT2, HSPA8, IL1B, RAB9B, BCL2More
Isofluranehsa05163Human cytomegalovirus infection3.92E-0416P31751, P62873, P0DP23, P61586, Q8NHW4, Q08828, P51828, P23458, P01584, P61073, P17252, Q13651, P18848, P63092, P61769, P01568AKT2, GNB1, CALM1, RHOA, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, CXCR4, PRKCA, IL10RA, ATF4, GNAS, B2M, IFNA21More
Isofluranehsa05164Influenza A7.10E-033P48551, P60709, P63261IFNAR2, ACTB, ACTG1More
Isofluranehsa05168Herpes simplex virus 1 infection2.45E-0518P01568, P01584, Q9UBU9, P23458, P42224, Q07955, Q01130, Q13243, Q13489, P51617, P61769, P31751, Q13398, Q6P280, Q03923, Q9UDV6, P10415, Q14232IFNA21, IL1B, NXF1, JAK1, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, B2M, AKT2, ZNF211, ZNF529, ZNF85, ZNF212, BCL2, EIF2B1More
Isofluranehsa05170Human immunodeficiency virus 1 infection4.12E-0512P31751, P62873, P0DP23, P61073, P17252, P61769, P01568, P51617, P19174, P23528, P10415, Q9Y6Q5AKT2, GNB1, CALM1, CXCR4, PRKCA, B2M, IFNA21, IRAK1, PLCG1, CFL1, BCL2, AP1M2More
Isofluranehsa05171Coronavirus disease - COVID-196.74E-0715P23396, P62753, P62249, P42677, P40429, Q9UHA3, P36578, Q02878, P62917, P32969, Q07020, P46776, P62910, P05386, O14786RPS3, RPS6, RPS16, RPS27, RPL13A, RSL24D1, RPL4, RPL6, RPL8, RPL9, RPL18, RPL27A, RPL32, RPLP1, NRP1More
Isofluranehsa05200Pathways in cancer4.30E-0928P23458, P08238, P42224, P19174, Q15311, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P31751, Q08828, P51828, P62873, P61073, P78417, O75293, Q15788, P0DP23, Q13557, O43521, P01568, P14784, P16871, P00734, P01042JAK1, HSP90AB1, STAT1, PLCG1, RALBP1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, AKT2, ADCY1, ADCY7, GNB1, CXCR4, GSTO1, GADD45B, NCOA1, CALM1, CAMK2D, BCL2L11, IFNA21, IL2RB, IL7R, F2, KNG1More
Isofluranehsa05204Chemical carcinogenesis3.70E-033P00325, P78417, P33260ADH1B, GSTO1, CYP2C18More
Isofluranehsa05206MicroRNAs in cancer4.07E-022P15311, P63279VIL2, UBE2IMore
Isofluranehsa05212Pancreatic cancer5.55E-036P31751, Q15311, P23458, P42224, Q13485, O75293AKT2, RALBP1, JAK1, STAT1, SMAD4, GADD45BMore
Isofluranehsa05214Glioma1.87E-056P0DP23, Q13557, P17252, P31751, P19174, O75293CALM1, CAMK2D, PRKCA, AKT2, PLCG1, GADD45BMore
Isofluranehsa05224Breast cancer3.88E-023P46531, Q9UM47, O15169NOTCH1, NOTCH3, AXIN1More
Isofluranehsa05225Hepatocellular carcinoma4.07E-022P60709, P63261ACTB, ACTG1More
Isofluranehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Isofluranehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Isofluranehsa05340Primary immunodeficiency1.06E-034P01730, P11912, Q8WV28, P07766CD4, CD79A, BLNK, CD3EMore
Isofluranehsa05410Hypertrophic cardiomyopathy1.02E-022P60709, P63261ACTB, ACTG1More
Isofluranehsa05412Arrhythmogenic right ventricular cardiomyopathy8.96E-032P60709, P63261ACTB, ACTG1More
Isofluranehsa05414Dilated cardiomyopathy1.73E-022P60709, P63261ACTB, ACTG1More
Isofluranehsa05415Diabetic cardiomyopathy2.75E-024P17252, P14598, Q15080, Q16718PRKCA, NCF1, NCF4, NDUFA5More
Isofluranehsa05416Viral myocarditis8.96E-032P60709, P63261ACTB, ACTG1More
Isofluranehsa05418Fluid shear stress and atherosclerosis3.64E-038P14598, P78417, P60709, P63261, P10415, P0DP23, P08238, Q92974NCF1, GSTO1, ACTB, ACTG1, BCL2, CALM1, HSP90AB1, ARHGEF2More

Community members of Isoflurane (SDC: 1.84)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P0DP23CALM1CalmodulinNone1Reported00.45520.147911.5235
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
P16389KCNA2Potassium voltageNonegated channel subfamily A member 2Predicted00.01310.083500.1736
P17658KCNA6Potassium voltageNonegated channel subfamily A member 6Predicted00.28270.078500.2984
P48058GRIA4Glutamate receptor 4Predicted00.40370.12090.37480.8184
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
P0DP25CALM3CalmodulinNone3Predicted00.56610.147900.5789
P0DP24CALM2CalmodulinNone2Predicted00.43760.147900.5147
Q9ULS6KCNS2Potassium voltageNonegated channel subfamily S member 2Predicted00.19550.041200.1801
P60660MYL6Myosin light polypeptide 6Predicted00.55950.06870.21750.6346
P24844MYL9Myosin regulatory light polypeptide 9Predicted00.00640.0630.60260.7318
P14649MYL6BMyosin light chain 6BPredicted00.04770.06530.21750.3719
P05976MYL1Myosin light chain 1/3, skeletal muscle isoformPredicted00.25810.061900.2528
O15182CETN3CentrinNone3Predicted00.18720.059400.2123
Q96A32MYLPFMyosin regulatory light chain 2, skeletal muscle isoformPredicted00.01350.04730.54120.6425
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)