PharmaCoNets of Isavuconazole (SPCN: 42.81 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Isavuconazolehsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Isavuconazolehsa00061Fatty acid biosynthesis4.83E-021P33121ACSL1More
Isavuconazolehsa00071Fatty acid degradation2.54E-033O75521, P11766, P33121ECI2, ADH5, ACSL1More
Isavuconazolehsa00190Oxidative phosphorylation3.50E-022Q16718, Q13488NDUFA5, TCIRG1More
Isavuconazolehsa00500Starch and sucrose metabolism2.37E-063O43451, P46976, P06737MGAM, GYG1, PYGLMore
Isavuconazolehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Isavuconazolehsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Isavuconazolehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Isavuconazolehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Isavuconazolehsa00600Sphingolipid metabolism3.01E-022Q9BX95, P06280SGPP1, GLAMore
Isavuconazolehsa00620Pyruvate metabolism4.20E-022P40926, P14550MDH2, AKR1A1More
Isavuconazolehsa00630Glyoxylate and dicarboxylate metabolism4.12E-032P40925, P15104MDH1, GLULMore
Isavuconazolehsa00730Thiamine metabolism6.59E-073Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Isavuconazolehsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Isavuconazolehsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Isavuconazolehsa00770Pantothenate and CoA biosynthesis2.27E-022O95498, O95497VNN2, VNN1More
Isavuconazolehsa00970Aminoacyl-tRNA biosynthesis4.85E-074O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Isavuconazolehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Isavuconazolehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Isavuconazolehsa01100Metabolic pathways1.01E-0335Q9NR34, P05089, O95455, P21953, P15144, P32320, P22748, P11766, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P42330, Q13093, Q08477, P15907, Q9NY28, P57054, Q9UNP4, Q9BX95, P09960, P37837, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q16718MAN1C1, ARG1, TGDS, BCKDHB, ANPEP, CDA, CA4, ADH5, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, AKR1C3, PLA2G7, CYP4F3, ST6GAL1, GALNT8, PIGP, ST3GAL5, SGPP1, LTA4H, TALDO1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, NDUFA5More
Isavuconazolehsa01240Biosynthesis of cofactors2.05E-022P36551, O60701CPOX, UGDHMore
Isavuconazolehsa03010Ribosome3.56E-0614P62753, P42677, P32969, P40429, P62917, P46776, Q9H0U6, Q07020, P62910, Q02878, P36578, P05386, P62249, P23396RPS6, RPS27, RPL9, RPL13A, RPL8, RPL27A, MRPL18, RPL18, RPL32, RPL6, RPL4, RPLP1, RPS16, RPS3More
Isavuconazolehsa03020RNA polymerase9.86E-072Q9GZM3, P52435POLR2J2, POLR2JMore
Isavuconazolehsa03040Spliceosome1.28E-0513O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Isavuconazolehsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Isavuconazolehsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Isavuconazolehsa04024cAMP signaling pathway1.53E-024P49019, P22694, P20020, P48058HCAR3, PRKACB, ATP2B1, GRIA4More
Isavuconazolehsa04060Cytokine-cytokine receptor interaction3.57E-034P37173, P78552, O75509, P80075TGFBR2, IL13RA1, TNFRSF21, CCL8More
Isavuconazolehsa04062Chemokine signaling pathway9.23E-0310P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Isavuconazolehsa04064NF-kappa B signaling pathway1.14E-0311Q13489, O00463, Q13546, P14778, Q9UDY8, Q13077, Q16548, Q8WV28, P24522, P09341, Q9UNE0BIRC3, TRAF5, RIPK1, IL1R1, MALT1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1, EDARMore
Isavuconazolehsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Isavuconazolehsa04072Phospholipase D signaling pathway9.70E-032Q92529, Q14344SHC3, GNA13More
Isavuconazolehsa04145Phagosome2.75E-024Q15080, P14598, P68371, Q13488NCF4, NCF1, TUBB2C, TCIRG1More
Isavuconazolehsa04150mTOR signaling pathway2.23E-023P42338, Q13322, P49841PIK3CB, GRB10, GSK3BMore
Isavuconazolehsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Isavuconazolehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Isavuconazolehsa04217Necroptosis1.48E-036P01568, Q13489, Q13546, P08238, O43633, Q08752IFNA21, BIRC3, RIPK1, HSP90AB1, CHMP2A, PPIDMore
Isavuconazolehsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Isavuconazolehsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Isavuconazolehsa04380Osteoclast differentiation4.80E-024P06239, P42338, P14778, Q8N149LCK, PIK3CB, IL1R1, LILRA2More
Isavuconazolehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Isavuconazolehsa04612Antigen processing and presentation1.51E-027P13765, P48382, P26715, P26717, Q13241, O43908, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8AMore
Isavuconazolehsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Isavuconazolehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Isavuconazolehsa04621NOD-like receptor signaling pathway3.36E-0311Q16539, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, Q13546, P01375, P09341, P12838MAPK14, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, RIPK1, TNF, CXCL1, DEFA4More
Isavuconazolehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Isavuconazolehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Isavuconazolehsa04650Natural killer cell mediated cytotoxicity1.15E-039P17252, P78314, O60880, P20963, Q13241, P26718, O75015, P26717, P26715PRKCA, SH3BP2, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Isavuconazolehsa04657IL-17 signaling pathway1.38E-036O00463, Q16539, P49841, P09341, P14780, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNFMore
Isavuconazolehsa04659Th17 cell differentiation2.08E-038P19174, P06239, P14784, P14778, P84022, Q13485, P08238, P07766PLCG1, LCK, IL2RB, IL1R1, SMAD3, SMAD4, HSP90AB1, CD3EMore
Isavuconazolehsa04660T cell receptor signaling pathway1.81E-028O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Isavuconazolehsa04662B cell receptor signaling pathway4.56E-046P49841, P42338, P60033, P07948, P21854, Q8N149GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2More
Isavuconazolehsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Isavuconazolehsa04713Circadian entrainment1.69E-023P17252, P48058, P22694PRKCA, GRIA4, PRKACBMore
Isavuconazolehsa04714Thermogenesis3.16E-023P22694, P33121, Q16718PRKACB, ACSL1, NDUFA5More
Isavuconazolehsa04721Synaptic vesicle cycle1.14E-022Q13488, P31645TCIRG1, SLC6A4More
Isavuconazolehsa04723Retrograde endocannabinoid signaling1.20E-034P17252, P48058, P22694, Q16718PRKCA, GRIA4, PRKACB, NDUFA5More
Isavuconazolehsa04724Glutamatergic synapse1.31E-023P48058, P22694, P17252GRIA4, PRKACB, PRKCAMore
Isavuconazolehsa04726Serotonergic synapse2.62E-023P22694, P17252, P31645PRKACB, PRKCA, SLC6A4More
Isavuconazolehsa04730Long-term depression3.52E-021Q14344GNA13More
Isavuconazolehsa04750Inflammatory mediator regulation of TRP channels3.72E-023P14778, P42338, P24723IL1R1, PIK3CB, PRKCHMore
Isavuconazolehsa04911Insulin secretion3.01E-022P22694, P17252PRKACB, PRKCAMore
Isavuconazolehsa04913Ovarian steroidogenesis1.28E-022P42330, P22694AKR1C3, PRKACBMore
Isavuconazolehsa04918Thyroid hormone synthesis3.01E-022P22694, P17252PRKACB, PRKCAMore
Isavuconazolehsa04925Aldosterone synthesis and secretion9.86E-033P17252, P22694, P20020PRKCA, PRKACB, ATP2B1More
Isavuconazolehsa04929GnRH secretion3.63E-022P42338, P49407PIK3CB, ARRB1More
Isavuconazolehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Isavuconazolehsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Isavuconazolehsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Isavuconazolehsa04961Endocrine and other factor-regulated calcium reabsorption9.85E-053P20020, P17252, P22694ATP2B1, PRKCA, PRKACBMore
Isavuconazolehsa04962Vasopressin-regulated water reabsorption6.61E-032P22694, Q13561PRKACB, DCTN2More
Isavuconazolehsa04970Salivary secretion7.14E-033P22694, P20020, P17252PRKACB, ATP2B1, PRKCAMore
Isavuconazolehsa04972Pancreatic secretion1.48E-032P20020, P17252ATP2B1, PRKCAMore
Isavuconazolehsa04973Carbohydrate digestion and absorption4.12E-032O43451, P42338MGAM, PIK3CBMore
Isavuconazolehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Isavuconazolehsa04976Bile secretion3.01E-022P22694, P08183PRKACB, ABCB1More
Isavuconazolehsa05010Alzheimer disease7.11E-039O15239, P13073, P18848, O15169, P67870, P05141, P12236, P28070, P43686NDUFA1, COX4I1, ATF4, AXIN1, CSNK2B, SLC25A5, SLC25A6, PSMB4, PSMC4More
Isavuconazolehsa05012Parkinson disease2.14E-027O15239, P13073, P05141, P12236, P18848, P28070, P43686NDUFA1, COX4I1, SLC25A5, SLC25A6, ATF4, PSMB4, PSMC4More
Isavuconazolehsa05016Huntington disease2.46E-053Q9GZM3, P52435, Q9NYC9POLR2J2, POLR2J, DNAH9More
Isavuconazolehsa05017Spinocerebellar ataxia4.66E-024P28070, P43686, P05141, P12236PSMB4, PSMC4, SLC25A5, SLC25A6More
Isavuconazolehsa05020Prion disease1.55E-0310P46531, O15239, P13073, P18848, P05141, P12236, P28070, P43686, P67870, P51636NOTCH1, NDUFA1, COX4I1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, CSNK2B, CAV2More
Isavuconazolehsa05022Pathways of neurodegeneration - multiple diseases5.20E-0415P67870, O15239, Q16718, P13073, P18848, Q13561, P48058, P05141, P12236, P17252, P20333, O15169, Q08752, P28070, P43686CSNK2B, NDUFA1, NDUFA5, COX4I1, ATF4, DCTN2, GRIA4, SLC25A5, SLC25A6, PRKCA, TNFRSF1B, AXIN1, PPID, PSMB4, PSMC4More
Isavuconazolehsa05031Amphetamine addiction1.69E-023P48058, P22694, P17252GRIA4, PRKACB, PRKCAMore
Isavuconazolehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Isavuconazolehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Isavuconazolehsa05110Vibrio cholerae infection3.01E-022P17252, P22694PRKCA, PRKACBMore
Isavuconazolehsa05120Epithelial cell signaling in Helicobacter pylori infection1.36E-034Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Isavuconazolehsa05132Salmonella infection9.85E-034Q13546, Q13489, O60282, P68371RIPK1, BIRC3, KIF5C, TUBB2CMore
Isavuconazolehsa05140Leishmaniasis1.77E-037P13612, O75015, P13765, O60603, P01375, P49006, Q16539ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MARCKSL1, MAPK14More
Isavuconazolehsa05144Malaria3.30E-024P60033, O60603, P35443, P26718CD81, TLR2, THBS4, KLRK1More
Isavuconazolehsa05146Amoebiasis5.00E-036P09341, P14778, P27930, P01375, O60603, P05089CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1More
Isavuconazolehsa05163Human cytomegalovirus infection3.44E-039P01375, P50151, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463TNF, GNG10, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Isavuconazolehsa05171Coronavirus disease - COVID-191.08E-0413P23396, P62753, P62249, P42677, P40429, P36578, Q02878, P62917, P32969, Q07020, P46776, P62910, P05386RPS3, RPS6, RPS16, RPS27, RPL13A, RPL4, RPL6, RPL8, RPL9, RPL18, RPL27A, RPL32, RPLP1More
Isavuconazolehsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Isavuconazolehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Isavuconazolehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Isavuconazolehsa05210Colorectal cancer3.43E-022Q9UKG1, P37173APPL1, TGFBR2More
Isavuconazolehsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Isavuconazolehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Isavuconazolehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Isavuconazolehsa05224Breast cancer4.51E-037P46531, Q9UM47, O15169, P49841, Q92837, P04637, P24522NOTCH1, NOTCH3, AXIN1, GSK3B, FRAT1, TP53, GADD45AMore
Isavuconazolehsa05225Hepatocellular carcinoma1.85E-022Q92529, P51531SHC3, SMARCA2More
Isavuconazolehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.55E-025O95267, P09693, O60603, Q16539, P01730RASGRP1, CD3G, TLR2, MAPK14, CD4More
Isavuconazolehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Isavuconazolehsa05415Diabetic cardiomyopathy3.54E-036P17252, P30405, P14598, Q15080, Q16718, P37173PRKCA, PPIF, NCF1, NCF4, NDUFA5, TGFBR2More
Isavuconazolehsa05418Fluid shear stress and atherosclerosis2.04E-048Q16539, P42338, P10599, P14780, P01375, P04637, P14778, P27930MAPK14, PIK3CB, TXN, MMP9, TNF, TP53, IL1R1, IL1R2More

Community members of Isavuconazole (SDC: 3.67)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P16389KCNA2Potassium voltageNonegated channel subfamily A member 2Predicted00.01310.083500.1736
P17658KCNA6Potassium voltageNonegated channel subfamily A member 6Predicted00.28270.078500.2984
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
P78508KCNJ10ATPNonesensitive inward rectifier potassium channel 10Predicted00.07310.08780.20670.4189
Q99712KCNJ15ATPNonesensitive inward rectifier potassium channel 15Predicted00.15870.07790.12670.3619
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
Q9ULS6KCNS2Potassium voltageNonegated channel subfamily S member 2Predicted00.19550.041200.1801
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)