PharmaCoNets of Irbesartan (SPCN: 262.69 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Irbesartanhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Irbesartanhsa00030Pentose phosphate pathway2.25E-033P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Irbesartanhsa00040Pentose and glucuronate interconversions9.59E-032P15121, P14550AKR1B1, AKR1A1More
Irbesartanhsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Irbesartanhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Irbesartanhsa00071Fatty acid degradation3.65E-034O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Irbesartanhsa00190Oxidative phosphorylation1.04E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Irbesartanhsa00220Arginine biosynthesis6.98E-043P15104, P05089, P49448GLUL, ARG1, GLUD2More
Irbesartanhsa00230Purine metabolism1.83E-033P21589, P20839, Q02153NT5E, IMPDH1, GUCY1B3More
Irbesartanhsa00240Pyrimidine metabolism1.94E-033P21589, P32320, P04183NT5E, CDA, TK1More
Irbesartanhsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Irbesartanhsa00310Lysine degradation2.86E-022Q96KQ7, Q02809EHMT2, PLOD1More
Irbesartanhsa00500Starch and sucrose metabolism5.62E-104O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Irbesartanhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Irbesartanhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Irbesartanhsa00520Amino sugar and nucleotide sugar metabolism4.15E-053Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Irbesartanhsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Irbesartanhsa00561Glycerolipid metabolism5.58E-043P15121, P14550, Q86XP1AKR1B1, AKR1A1, DGKHMore
Irbesartanhsa00564Glycerophospholipid metabolism2.00E-024P48651, Q9Y6K0, P35790, Q9Y259PTDSS1, CEPT1, CHKA, CHKBMore
Irbesartanhsa00565Ether lipid metabolism1.66E-052Q9Y6K0, Q8N661CEPT1, TMEM86BMore
Irbesartanhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Irbesartanhsa00591Linoleic acid metabolism1.29E-031P11712CYP2C9More
Irbesartanhsa00600Sphingolipid metabolism2.65E-033Q9BX95, Q06136, P15289SGPP1, FVT1, ARSAMore
Irbesartanhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series6.13E-052P06865, O75752HEXA, B3GALNT1More
Irbesartanhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Irbesartanhsa00630Glyoxylate and dicarboxylate metabolism3.82E-083P40925, P40926, P15104MDH1, MDH2, GLULMore
Irbesartanhsa00730Thiamine metabolism5.62E-103Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Irbesartanhsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Irbesartanhsa00760Nicotinate and nicotinamide metabolism6.37E-041P21589NT5EMore
Irbesartanhsa00770Pantothenate and CoA biosynthesis4.81E-073O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Irbesartanhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Irbesartanhsa00790Folate biosynthesis4.74E-022P07101, P42330TH, AKR1C3More
Irbesartanhsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Irbesartanhsa00920Sulfur metabolism3.18E-021Q16762TSTMore
Irbesartanhsa00970Aminoacyl-tRNA biosynthesis2.48E-084O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Irbesartanhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Irbesartanhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Irbesartanhsa00983Drug metabolism - other enzymes7.62E-053P04183, P32320, P05164TK1, CDA, MPOMore
Irbesartanhsa01100Metabolic pathways5.09E-0336Q9NR34, Q9Y234, P05089, Q6ZQY3, P32320, Q02153, P20839, P22748, P55809, P06280, Q16875, O43286, O43451, Q9Y6K0, P05186, P24666, Q86XP1, P14550, Q9HCC0, P33121, Q9UHK6, Q86VZ5, Q9BVK2, P57054, Q9UNP4, Q9BX95, P37837, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q99437, Q9NVH6MAN1C1, LIPT1, ARG1, GADL1, CDA, GUCY1B3, IMPDH1, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, CEPT1, ALPL, ACP1, DGKH, AKR1A1, MCCC2, ACSL1, AMACR, SGMS1, ALG8, PIGP, ST3GAL5, SGPP1, TALDO1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, ATP6V0B, TMLHEMore
Irbesartanhsa01230Biosynthesis of amino acids3.13E-036P51854, P60891, Q99707, P50213, P05089, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, TALDO1More
Irbesartanhsa01523Antifolate resistance1.72E-044P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Irbesartanhsa01524Platinum drug resistance1.13E-025P10415, Q13489, P78417, P23025, P43246BCL2, BIRC3, GSTO1, XPA, MSH2More
Irbesartanhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Irbesartanhsa03008Ribosome biogenesis in eukaryotes4.44E-047Q9NYH9, P19784, P67870, P78345, Q9BVP2, O15381, Q9GZY0UTP6, CSNK2A2, CSNK2B, RPP38, GNL3, NVL, NXF2; NXF2BMore
Irbesartanhsa03010Ribosome1.60E-029P30050, P40429, P62906, P62917, Q9H0U6, P36578, P05386, P62249, P23396RPL12, RPL13A, RPL10A, RPL8, MRPL18, RPL4, RPLP1, RPS16, RPS3More
Irbesartanhsa03013RNA transport4.77E-0821O14980, P52298, Q09161, O14893, P61326, P38919, Q15287, Q9UBU9, P37198, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, O75822, P78345, P20042, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, RNPS1, NXF1, NUP62, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF4A2, TACC3, FXR1More
Irbesartanhsa03020RNA polymerase3.74E-065P30876, P24928, P62487, Q9GZM3, P52435POLR2B, POLR2A, POLR2G, POLR2J2, POLR2JMore
Irbesartanhsa03022Basal transcription factors3.52E-033O00268, Q5H9L4, Q15544TAF4, TAF7L, TAF11More
Irbesartanhsa03030DNA replication1.48E-023P49005, P33993, P15927POLD2, MCM7, RPA2More
Irbesartanhsa03040Spliceosome2.58E-1222Q14562, O43143, O60508, Q99633, P17844, P08579, Q15427, P26368, P52298, P51991, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, Q9UMS4, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, PRPF18, DDX5, SNRPB2, SF3B4, U2AF2, NCBP2, HNRPA3, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, PRPF19, HSPA8, WBP11, PPIH, ASCC3L1More
Irbesartanhsa03050Proteasome1.53E-031P55036PSMD4More
Irbesartanhsa03060Protein export1.20E-032P37108, Q15005SRP14, SPCS2More
Irbesartanhsa03430Mismatch repair4.38E-021P20585MSH3More
Irbesartanhsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Irbesartanhsa03460Fanconi anemia pathway6.19E-033Q9BXW9, O94782, P07992FANCD2, USP1, ERCC1More
Irbesartanhsa04012ErbB signaling pathway3.74E-023P21860, Q13557, O14944ERBB3, CAMK2D, EREGMore
Irbesartanhsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Irbesartanhsa04015Rap1 signaling pathway2.00E-0516P20827, P49767, P06213, P63261, Q96FS4, P11215, P25116, Q8TEU7, Q13009, O00522, Q7LDG7, P42338, P0DP23, P08514, P17252, P19174EFNA1, VEGFC, INSR, ACTG1, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, KRIT1, RASGRP2, PIK3CB, CALM1, ITGA2B, PRKCA, PLCG1More
Irbesartanhsa04020Calcium signaling pathway5.60E-0916Q96DU7, P45880, Q16566, Q13557, P17252, P21860, O15399, P25116, P0DP23, P05141, P12236, P51828, P26678, P63092, P23634, P49767ITPKC, VDAC2, CAMK4, CAMK2D, PRKCA, ERBB3, GRIN2D, F2R, CALM1, SLC25A5, SLC25A6, ADCY7, PLN, GNAS, ATP2B4, VEGFCMore
Irbesartanhsa04022cGMP-PKG signaling pathway1.00E-0411P61586, P26678, Q99941, P18848, P23634, Q8WYR1, P51828, P05141, P12236, P45880, P0DP24RHOA, PLN, CREBL1, ATF4, ATP2B4, PIK3R5, ADCY7, SLC25A5, SLC25A6, VDAC2, CALM2More
Irbesartanhsa04024cAMP signaling pathway3.94E-0411P63092, P42338, P26678, P0DP23, P23634, P61586, Q16566, Q13370, O15399, P25116, Q13009GNAS, PIK3CB, PLN, CALM1, ATP2B4, RHOA, CAMK4, PDE3B, GRIN2D, F2R, TIAM1More
Irbesartanhsa04060Cytokine-cytokine receptor interaction3.25E-0519P27930, P14778, P26842, Q9UHF4, Q13651, P48551, P16871, P78552, P25024, Q9UBD3, P47992, P02775, O75509, P09341, P32248, P51684, P18510, P09603, P01730IL1R2, IL1R1, CD27, IL20RA, IL10RA, IFNAR2, IL7R, IL13RA1, CXCR1, XCL2, XCL1, PPBP, TNFRSF21, CXCL1, CCR7, CCR6, IL1RN, CSF1, CD4More
Irbesartanhsa04061Viral protein interaction with cytokine and cytokine receptor1.26E-057P51684, P32248, P09341, P02775, P47992, Q9UBD3, Q9UHF4CCR6, CCR7, CXCL1, PPBP, XCL1, XCL2, IL20RAMore
Irbesartanhsa04062Chemokine signaling pathway1.43E-0417P25024, P25025, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P49841, Q8WYR1CXCR1, CXCR2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, GSK3B, PIK3R5More
Irbesartanhsa04064NF-kappa B signaling pathway2.09E-0924P10415, P51617, Q12933, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, P19784, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7BCL2, IRAK1, TRAF2, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, CSNK2A2, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLDMore
Irbesartanhsa04066HIF-1 signaling pathway3.40E-023Q09472, P07195, P10415EP300, LDHB, BCL2More
Irbesartanhsa04068FoxO signaling pathway3.52E-021Q96BR1SGK3More
Irbesartanhsa04070Phosphatidylinositol signaling system4.87E-047P0DP23, Q14643, P42338, P23743, O14732, P27987, P17252CALM1, ITPR1, PIK3CB, DGKA, IMPA2, ITPKB, PRKCAMore
Irbesartanhsa04071Sphingolipid signaling pathway2.46E-0510P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415, Q9UQC2PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2, GAB2More
Irbesartanhsa04072Phospholipase D signaling pathway7.71E-045Q92529, P61586, O14986, Q14344, P63092SHC3, RHOA, PIP5K1B, GNA13, GNASMore
Irbesartanhsa04080Neuroactive ligand-receptor interaction2.76E-026Q15722, P21453, O00398, P25116, P21462, Q16581LTB4R, S1PR1, P2RY10, F2R, FPR1, C3AR1More
Irbesartanhsa04110Cell cycle2.12E-0612Q9UJX4, P06493, O60566, Q09472, P24522, O75293, P04637, P49918, P30304, P33981, P42773, P01106ANAPC5, CDK1, BUB1B, EP300, GADD45A, GADD45B, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYCMore
Irbesartanhsa04114Oocyte meiosis3.54E-055Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Irbesartanhsa04120Ubiquitin mediated proteolysis2.51E-036Q14145, Q13042, P62837, Q15751, O95071, P0CG47KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBBMore
Irbesartanhsa04122Sulfur relay system3.18E-021Q16762TSTMore
Irbesartanhsa04137Mitophagy - animal6.72E-044P19784, P67870, Q07817, P0CG47CSNK2A2, CSNK2B, BCL2L1, UBBMore
Irbesartanhsa04140Autophagy - animal2.86E-036Q9NQL2, P22694, Q14643, P10415, Q9H1Y0, Q04759RRAGD, PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Irbesartanhsa04141Protein processing in endoplasmic reticulum2.94E-048P18848, Q15437, Q99941, O75460, P11142, Q9H3Z4, P07900, Q9NR31ATF4, SEC23B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, SAR1AMore
Irbesartanhsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Irbesartanhsa04144Endocytosis2.89E-038P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Irbesartanhsa04145Phagosome5.64E-0713O75015, P63261, Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P27824, P13765FCGR3B, ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, CANX, HLA-DOBMore
Irbesartanhsa04150mTOR signaling pathway2.23E-036P42338, Q02750, Q9NQL2, P51812, Q13322, P49841PIK3CB, MAP2K1, RRAGD, RPS6KA3, GRB10, GSK3BMore
Irbesartanhsa04151PI3K-Akt signaling pathway2.31E-0625P62753, P42338, P21860, P43657, O43521, P27348, P20827, O14944, P49767, P07900, P08238, Q15831, Q8WYR1, P63218, P50151, O15335, Q13751, P22105, P14784, Q99941, P18848, O00141, Q6ZUJ8, P30281, O95988RPS6, PIK3CB, ERBB3, P2RY5, BCL2L11, YWHAQ, EFNA1, EREG, VEGFC, HSP90AA1, HSP90AB1, STK11, PIK3R5, GNG5, GNG10, CHAD, LAMB3, TNXB, IL2RB, CREBL1, ATF4, SGK, PIK3AP1, CCND3, TCL1BMore
Irbesartanhsa04210Apoptosis3.78E-0514P04637, P10415, O76075, P01375, Q9NR28, O75460, P24522, Q16548, Q13077, O43521, P43234, Q9UBR2, P18848, Q14643TP53, BCL2, DFFB, TNF, DIABLO, ERN1, GADD45A, BCL2A1, TRAF1, BCL2L11, CTSO, CTSZ, ATF4, ITPR1More
Irbesartanhsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Irbesartanhsa04213Longevity regulating pathway - multiple species2.82E-023Q08828, P51828, P0DMV8ADCY1, ADCY7, HSPA1AMore
Irbesartanhsa04217Necroptosis5.40E-0819P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, P10415, Q9H444, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP4B, CHMP2A, PPIDMore
Irbesartanhsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Irbesartanhsa04261Adrenergic signaling in cardiomyocytes2.59E-0512P63092, P51828, Q99941, P18848, P26678, Q16537, P0DP23, Q13557, P17252, P10415, P20020, P23634GNAS, ADCY7, CREBL1, ATF4, PLN, PPP2R5E, CALM1, CAMK2D, PRKCA, BCL2, ATP2B1, ATP2B4More
Irbesartanhsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Irbesartanhsa04310Wnt signaling pathway2.00E-044P61586, P17612, P19784, P67870RHOA, PRKACA, CSNK2A2, CSNK2BMore
Irbesartanhsa04330Notch signaling pathway2.46E-033Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Irbesartanhsa04340Hedgehog signaling pathway2.36E-033P49841, P17612, P22694GSK3B, PRKACA, PRKACBMore
Irbesartanhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Irbesartanhsa04360Axon guidance2.47E-037P16333, P20827, O95631, P42338, P07332, P23528, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1More
Irbesartanhsa04370VEGF signaling pathway2.22E-063P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Irbesartanhsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Irbesartanhsa04380Osteoclast differentiation1.86E-0514Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P42338, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, PIK3CB, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Irbesartanhsa04390Hippo signaling pathway3.06E-046P63261, Q13485, P04628, Q9UJU2, O43623, Q13489ACTG1, SMAD4, WNT1, LEF1, SNAI2, BIRC3More
Irbesartanhsa04510Focal adhesion3.86E-039Q15942, O14986, P17252, P61586, Q16363, Q13489, P10415, P49767, P63261ZYX, PIP5K1B, PRKCA, RHOA, LAMA4, BIRC3, BCL2, VEGFC, ACTG1More
Irbesartanhsa04512ECM-receptor interaction3.73E-022P07359, P08514GP1BA, ITGA2BMore
Irbesartanhsa04514Cell adhesion molecules8.19E-033P16109, P56750, O00501SELP, CLDN17, CLDN5More
Irbesartanhsa04520Adherens junction1.66E-047Q13485, Q9UJU2, O43623, P19784, P67870, P61586, P63261SMAD4, LEF1, SNAI2, CSNK2A2, CSNK2B, RHOA, ACTG1More
Irbesartanhsa04530Tight junction2.47E-055Q8TEU7, P16989, P56750, O00501, Q14247RAPGEF6, CSDA, CLDN17, CLDN5, CTTNMore
Irbesartanhsa04540Gap junction1.53E-034P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Irbesartanhsa04610Complement and coagulation cascades2.48E-077P25116, P09871, P00734, P0C0L4, P12259, P11215, P05107F2R, C1S, F2, C4A, F5, ITGAM, ITGB2More
Irbesartanhsa04611Platelet activation2.96E-067P25116, Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359F2R, TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Irbesartanhsa04612Antigen processing and presentation6.84E-069P13765, P48382, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNFMore
Irbesartanhsa04613Neutrophil extracellular trap formation2.34E-0830P19174, P17252, P57764, P16109, P11215, O60603, P05164, P08246, P05107, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q93077, P62807, P33778, Q16778, O60814, P68431, P14598, Q15080, P08311, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PLCG1, PRKCA, GSDMDC1, SELP, ITGAM, TLR2, MPO, ELA2, ITGB2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, CTSG, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Irbesartanhsa04614Renin-angiotensin system7.48E-034P50052, P15144, P08311, O75787AGTR2, ANPEP, CTSG, ATP6AP2More
Irbesartanhsa04621NOD-like receptor signaling pathway3.40E-028Q14643, P10599, P43490, O00463, P29728, P01375, P09341, P12838ITPR1, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4More
Irbesartanhsa04623Cytosolic DNA-sensing pathway6.28E-075P01584, P01568, Q13546, P25963, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, CCL4L2More
Irbesartanhsa04625C-type lectin receptor signaling pathway9.91E-049Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Irbesartanhsa04640Hematopoietic cell lineage1.22E-0617P13612, P21926, P14778, P27930, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P09603, P01584ITGA4, CD9, IL1R1, IL1R2, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, CSF1, IL1BMore
Irbesartanhsa04650Natural killer cell mediated cytotoxicity2.17E-1215P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Irbesartanhsa04657IL-17 signaling pathway2.46E-058O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Irbesartanhsa04658Th1 and Th2 cell differentiation1.02E-1517Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P78504, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, JAG1, HLA-DOB, JAK1, RUNX3More
Irbesartanhsa04659Th17 cell differentiation3.95E-1421Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Irbesartanhsa04660T cell receptor signaling pathway4.28E-1113P01375, Q9UDY8, Q04759, O95267, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Irbesartanhsa04662B cell receptor signaling pathway2.89E-066P49841, P42338, P60033, P07948, P21854, Q8N149GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2More
Irbesartanhsa04664Fc epsilon RI signaling pathway1.62E-047P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5More
Irbesartanhsa04666Fc gamma R-mediated phagocytosis8.04E-067P42338, P23528, P49006, P06396, O14494, P14598, P17252PIK3CB, CFL1, MARCKSL1, GSN, PLPP1, NCF1, PRKCAMore
Irbesartanhsa04668TNF signaling pathway1.99E-0410P01375, O00463, Q16539, Q99941, P18848, P01584, P20749, P14780, P20333, O95429TNF, TRAF5, MAPK14, CREBL1, ATF4, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Irbesartanhsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Irbesartanhsa04713Circadian entrainment3.41E-035P0DP23, P17252, P62873, Q14643, P63092CALM1, PRKCA, GNB1, ITPR1, GNASMore
Irbesartanhsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Irbesartanhsa04720Long-term potentiation5.78E-088P17252, Q16566, P16298, P0DP23, P51812, O15399, Q02750, Q14643PRKCA, CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, MAP2K1, ITPR1More
Irbesartanhsa04721Synaptic vesicle cycle1.98E-044Q13488, Q99437, P43005, P31645TCIRG1, ATP6V0B, SLC1A1, SLC6A4More
Irbesartanhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Irbesartanhsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Irbesartanhsa04724Glutamatergic synapse4.09E-068P48058, O15399, P43003, P63092, P62873, P63218, P50151, P15104GRIA4, GRIN2D, SLC1A3, GNAS, GNB1, GNG5, GNG10, GLULMore
Irbesartanhsa04725Cholinergic synapse2.61E-0511P51828, Q14643, P17252, P62873, P63218, P50151, P18848, Q16566, Q13557, P42338, P10415ADCY7, ITPR1, PRKCA, GNB1, GNG5, GNG10, ATF4, CAMK4, CAMK2D, PIK3CB, BCL2More
Irbesartanhsa04726Serotonergic synapse3.41E-035P63092, Q14643, P17252, P62873, P33260GNAS, ITPR1, PRKCA, GNB1, CYP2C18More
Irbesartanhsa04727GABAergic synapse1.56E-033P63218, P50151, P15104GNG5, GNG10, GLULMore
Irbesartanhsa04728Dopaminergic synapse4.12E-039P14416, P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407DRD2, GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1More
Irbesartanhsa04730Long-term depression3.52E-021Q14344GNA13More
Irbesartanhsa04742Taste transduction3.91E-021P17612PRKACAMore
Irbesartanhsa04744Phototransduction3.21E-042P62873, P0DP23GNB1, CALM1More
Irbesartanhsa04750Inflammatory mediator regulation of TRP channels1.99E-0513P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Irbesartanhsa04810Regulation of actin cytoskeleton2.58E-023Q15746, P08514, P25116MYLK, ITGA2B, F2RMore
Irbesartanhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Irbesartanhsa04911Insulin secretion2.87E-075P51828, P63092, Q99941, P18848, Q13557ADCY7, GNAS, CREBL1, ATF4, CAMK2DMore
Irbesartanhsa04912GnRH signaling pathway8.90E-0510P17252, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694PRKCA, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACBMore
Irbesartanhsa04913Ovarian steroidogenesis2.52E-021P06213INSRMore
Irbesartanhsa04914Progesterone-mediated oocyte maturation1.15E-057Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1More
Irbesartanhsa04915Estrogen signaling pathway7.24E-059Q99941, P18848, Q08828, P51828, P07900, P0DMV8, P11142, P0DP23, Q15788CREBL1, ATF4, ADCY1, ADCY7, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1More
Irbesartanhsa04916Melanogenesis4.47E-034P0DP23, Q9UJU2, P17252, P04628CALM1, LEF1, PRKCA, WNT1More
Irbesartanhsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Irbesartanhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Irbesartanhsa04921Oxytocin signaling pathway4.19E-024P0DP23, P17252, Q16566, P63261CALM1, PRKCA, CAMK4, ACTG1More
Irbesartanhsa04923Regulation of lipolysis in adipocytes3.76E-021P06213INSRMore
Irbesartanhsa04924Renin secretion3.77E-022Q13370, P0DP23PDE3B, CALM1More
Irbesartanhsa04925Aldosterone synthesis and secretion1.25E-1011Q14643, Q99941, P18848, P51828, P0DP23, P63092, P17252, Q16566, Q13557, P20020, P23634ITPR1, CREBL1, ATF4, ADCY7, CALM1, GNAS, PRKCA, CAMK4, CAMK2D, ATP2B1, ATP2B4More
Irbesartanhsa04926Relaxin signaling pathway5.00E-048P42338, P63218, P50151, Q99941, P18848, P49767, P51828, P49407PIK3CB, GNG5, GNG10, CREBL1, ATF4, VEGFC, ADCY7, ARRB1More
Irbesartanhsa04927Cortisol synthesis and secretion3.00E-044Q99941, P18848, P51828, P63092CREBL1, ATF4, ADCY7, GNASMore
Irbesartanhsa04928Parathyroid hormone synthesis, secretion and action1.39E-035P51828, P63092, P61586, Q99941, P18848ADCY7, GNAS, RHOA, CREBL1, ATF4More
Irbesartanhsa04929GnRH secretion3.30E-032P42338, P49407PIK3CB, ARRB1More
Irbesartanhsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Irbesartanhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Irbesartanhsa04932Non-alcoholic fatty liver disease7.37E-0610P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O95298TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFC2More
Irbesartanhsa04933AGE-RAGE signaling pathway in diabetic complications2.93E-037P84022, Q13485, P10415, P42338, P49767, P17252, P19174SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PRKCA, PLCG1More
Irbesartanhsa04934Cushing syndrome5.03E-086Q99941, P18848, P51828, P63092, O15169, Q13557CREBL1, ATF4, ADCY7, GNAS, AXIN1, CAMK2DMore
Irbesartanhsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Irbesartanhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Irbesartanhsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Irbesartanhsa04960Aldosterone-regulated sodium reabsorption2.32E-032P06213, P48048INSR, KCNJ1More
Irbesartanhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Irbesartanhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Irbesartanhsa04966Collecting duct acid secretion5.23E-064Q13488, P02730, P00918, Q9Y666TCIRG1, SLC4A1, CA2, SLC12A7More
Irbesartanhsa04970Salivary secretion1.12E-047Q08828, P51828, Q14643, P20020, P23634, P17252, P0DP23ADCY1, ADCY7, ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1More
Irbesartanhsa04971Gastric acid secretion1.87E-036P51828, P17252, P15311, P63261, P0DP23, Q13557ADCY7, PRKCA, VIL2, ACTG1, CALM1, CAMK2DMore
Irbesartanhsa04972Pancreatic secretion1.42E-035Q14643, P20020, P17252, P63092, P61586ITPR1, ATP2B1, PRKCA, GNAS, RHOAMore
Irbesartanhsa04973Carbohydrate digestion and absorption4.12E-032O43451, P42338MGAM, PIK3CBMore
Irbesartanhsa04976Bile secretion2.51E-035Q08828, P51828, P22694, P08183, Q14032ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Irbesartanhsa04978Mineral absorption3.94E-022P23634, Q9BXS9ATP2B4, SLC26A6More
Irbesartanhsa05010Alzheimer disease8.47E-0515Q92542, O15239, P05496, P13073, P12074, O75460, P0DP24, P01584, P18848, O15169, P05141, P12236, P45880, P43686, P62195NCSTN, NDUFA1, ATP5G1, COX4I1, COX6A1, ERN1, CALM2, IL1B, ATF4, AXIN1, SLC25A5, SLC25A6, VDAC2, PSMC4, PSMC5More
Irbesartanhsa05012Parkinson disease3.66E-0412O15239, P13073, P05496, P05141, P12236, P63092, O75460, P18848, P43686, P62195, P0DP24, Q13557NDUFA1, COX4I1, ATP5G1, SLC25A5, SLC25A6, GNAS, ERN1, ATF4, PSMC4, PSMC5, CALM2, CAMK2DMore
Irbesartanhsa05014Amyotrophic lateral sclerosis4.61E-0315O15399, P10415, P20333, O15239, P05496, P18848, Q13509, P68371, P43686, P62195, P51991, Q53GS7, P35658, P63261, Q9GZY0GRIN2D, BCL2, TNFRSF1B, NDUFA1, ATP5G1, ATF4, TUBB3, TUBB2C, PSMC4, PSMC5, HNRPA3, GLE1, NUP214, ACTG1, NXF2; NXF2BMore
Irbesartanhsa05016Huntington disease1.17E-0413O95298, P13073, P12074, Q9GZM3, P24928, P30876, P62487, P52435, P05141, O75460, P28070, P55036, O00232NDUFC2, COX4I1, COX6A1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, ERN1, PSMB4, PSMD4, PSMD12More
Irbesartanhsa05020Prion disease1.30E-0419P01584, P46531, P11142, O15239, O14521, P05496, P12074, Q14643, P18848, P05141, P12236, P45880, P43686, P62195, Q13509, P68371, Q99941, P14598, Q15080IL1B, NOTCH1, HSPA8, NDUFA1, SDHD, ATP5G1, COX6A1, ITPR1, ATF4, SLC25A5, SLC25A6, VDAC2, PSMC4, PSMC5, TUBB3, TUBB2C, CREBL1, NCF1, NCF4More
Irbesartanhsa05022Pathways of neurodegeneration - multiple diseases2.22E-0422Q14643, Q13509, P68371, P10415, O15239, O14521, P13073, P05496, O75460, P18848, Q13561, P05141, P12236, P17252, P20333, O15169, P01584, P0DP24, P0DP23, Q13557, P43686, P62195ITPR1, TUBB3, TUBB2C, BCL2, NDUFA1, SDHD, COX4I1, ATP5G1, ERN1, ATF4, DCTN2, SLC25A5, SLC25A6, PRKCA, TNFRSF1B, AXIN1, IL1B, CALM2, CALM1, CAMK2D, PSMC4, PSMC5More
Irbesartanhsa05030Cocaine addiction2.63E-033P63092, Q99941, P18848GNAS, CREBL1, ATF4More
Irbesartanhsa05031Amphetamine addiction3.94E-068O15399, P0DP23, Q16566, Q13557, P63092, Q99941, P18848, P17252GRIN2D, CALM1, CAMK4, CAMK2D, GNAS, CREBL1, ATF4, PRKCAMore
Irbesartanhsa05032Morphine addiction2.47E-033P62873, P48169, P63092GNB1, GABRA4, GNASMore
Irbesartanhsa05034Alcoholism1.13E-058Q13547, P63218, P50151, Q93077, P62807, Q16778, O60814, P68431HDAC1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Irbesartanhsa05100Bacterial invasion of epithelial cells4.54E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Irbesartanhsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Irbesartanhsa05120Epithelial cell signaling in Helicobacter pylori infection1.91E-047Q16539, Q99437, P09341, P10145, P25024, P25025, P07948MAPK14, ATP6V0B, CXCL1, IL8, CXCR1, CXCR2, LYNMore
Irbesartanhsa05130Pathogenic Escherichia coli infection7.39E-034Q14247, P56750, O00501, P25116CTTN, CLDN17, CLDN5, F2RMore
Irbesartanhsa05131Shigellosis2.93E-026Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q13315RRAGD, UBB, SEPT6, ELMO2, PTK2, ATMMore
Irbesartanhsa05132Salmonella infection2.45E-0813P51617, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371IRAK1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2CMore
Irbesartanhsa05133Pertussis8.18E-087P11215, P05107, P0DP23, P23528, P09871, P0C0L4, Q02556ITGAM, ITGB2, CALM1, CFL1, C1S, C4A, IRF8More
Irbesartanhsa05134Legionellosis2.82E-023P01584, Q9NR31, P0DMV8IL1B, SAR1A, HSPA1AMore
Irbesartanhsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Irbesartanhsa05140Leishmaniasis2.05E-0815P13612, O75015, P14598, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Irbesartanhsa05143African trypanosomiasis5.26E-064P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Irbesartanhsa05144Malaria6.64E-089P60033, P69905, P68871, O60603, P01375, P35443, P01584, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, IL8, KLRK1More
Irbesartanhsa05145Toxoplasmosis3.96E-022P28068, Q16787HLA-DMB, LAMA3More
Irbesartanhsa05146Amoebiasis2.21E-0811P01584, Q13751, P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311IL1B, LAMB3, CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSGMore
Irbesartanhsa05152Tuberculosis8.64E-059Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Irbesartanhsa05160Hepatitis C1.16E-036P52630, P60033, Q9NZJ5, P49841, P01375, P48023STAT2, CD81, EIF2AK3, GSK3B, TNF, FASLGMore
Irbesartanhsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Irbesartanhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Irbesartanhsa05163Human cytomegalovirus infection4.52E-0724P01375, P62873, P63218, P50151, Q14643, P0DP23, P61586, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P17252, Q13651, P25025, Q16539, P63092, P04637, Q13546, O00463, P61769, P01568TNF, GNB1, GNG5, GNG10, ITPR1, CALM1, RHOA, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, PRKCA, IL10RA, CXCR2, MAPK14, GNAS, TP53, RIPK1, TRAF5, B2M, IFNA21More
Irbesartanhsa05165Human papillomavirus infection2.01E-023Q16787, Q02930, Q13315LAMA3, CREB5, ATMMore
Irbesartanhsa05166Human T-cell leukemia virus 1 infection2.91E-023Q02930, P28068, Q13315CREB5, HLA-DMB, ATMMore
Irbesartanhsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Irbesartanhsa05168Herpes simplex virus 1 infection1.04E-0518Q9UKJ0, P25963, P01568, Q05823, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13489, P42338, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9UDV6, P10415PILRB, NFKBIA, IFNA21, RNASEL, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PIK3CB, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Irbesartanhsa05169Epstein-Barr virus infection4.60E-0620P13765, Q13547, Q92769, P04637, Q13546, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, P48551, P01375, O60603, P29728, P51617, P07766, P09693, P20963HLA-DOB, HDAC1, HDAC2, TP53, RIPK1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, IFNAR2, TNF, TLR2, OAS2, IRAK1, CD3E, CD3G, CD247More
Irbesartanhsa05170Human immunodeficiency virus 1 infection1.97E-0920Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q13546, O00463, Q14643, P01568, P51617, O60603, Q13315, P23528, P09693, P10415, Q93034, Q9Y6Q5, P20333MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, RIPK1, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, ATM, CFL1, CD3G, BCL2, CUL5, AP1M2, TNFRSF1BMore
Irbesartanhsa05200Pathways in cancer1.36E-0534Q13751, P42338, P08238, P42224, P19174, P04637, Q9UJU2, P17252, Q09472, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, Q13077, P49767, P43657, P25116, P63218, P50151, Q14344, O95267, Q7LDG7, P78417, P24522, O75293, P0DP23, P01568, P14784, P40189, P16871LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, TP53, LEF1, PRKCA, EP300, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, TRAF1, VEGFC, P2RY5, F2R, GNG5, GNG10, GNA13, RASGRP1, RASGRP2, GSTO1, GADD45A, GADD45B, CALM1, IFNA21, IL2RB, IL6ST, IL7RMore
Irbesartanhsa05202Transcriptional misregulation in cancer8.16E-0827Q92570, Q12778, Q15532, Q13315, O94812, P58340, P10145, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522NR4A3, FOXO1, SS18, ATM, BAIAP3, MLF1, IL8, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Irbesartanhsa05203Viral carcinogenesis5.69E-0714Q12933, Q99941, P18848, P06746, P07948, P27348, Q13547, Q15283, P61586, P12814, P61978, P62807, Q16778, O60814TRAF2, CREBL1, ATF4, POLB, LYN, YWHAQ, HDAC1, RASA2, RHOA, ACTN1, HNRPK, HIST1H2BC, HIST2H2BE, H2BC12More
Irbesartanhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Irbesartanhsa05205Proteoglycans in cancer1.09E-0210Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63More
Irbesartanhsa05206MicroRNAs in cancer1.62E-047P15311, P21860, P61978, P46531, P63279, P22105, P61586VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RHOAMore
Irbesartanhsa05210Colorectal cancer2.41E-024P10415, P04637, Q9UJU2, P24522BCL2, TP53, LEF1, GADD45AMore
Irbesartanhsa05212Pancreatic cancer4.96E-046P42338, P42224, P37173, P84022, Q13485, O75293PIK3CB, STAT1, TGFBR2, SMAD3, SMAD4, GADD45BMore
Irbesartanhsa05213Endometrial cancer1.98E-045O15169, Q9UJU2, Q02750, P04637, P24522AXIN1, LEF1, MAP2K1, TP53, GADD45AMore
Irbesartanhsa05214Glioma5.64E-067P0DP23, Q16566, P17252, P42338, P04637, P24522, O75293CALM1, CAMK4, PRKCA, PIK3CB, TP53, GADD45A, GADD45BMore
Irbesartanhsa05215Prostate cancer1.94E-024P10415, Q9UJU2, Q09472, P04637BCL2, LEF1, EP300, TP53More
Irbesartanhsa05216Thyroid cancer8.01E-075P01106, Q9UJU2, P04637, P24522, O75293MYC, LEF1, TP53, GADD45A, GADD45BMore
Irbesartanhsa05217Basal cell carcinoma8.10E-076Q13635, P04628, P49841, Q9UJU2, P04637, P24522PTCH1, WNT1, GSK3B, LEF1, TP53, GADD45AMore
Irbesartanhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Irbesartanhsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Irbesartanhsa05222Small cell lung cancer1.94E-024P10415, Q13077, P04637, P24522BCL2, TRAF1, TP53, GADD45AMore
Irbesartanhsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Irbesartanhsa05224Breast cancer5.34E-035Q9UJU2, P49841, Q92837, P04637, P24522LEF1, GSK3B, FRAT1, TP53, GADD45AMore
Irbesartanhsa05225Hepatocellular carcinoma1.85E-022Q92529, P51531SHC3, SMARCA2More
Irbesartanhsa05226Gastric cancer7.56E-057Q02750, Q9UJU2, O15169, P04637, P24522, P14923, P10415MAP2K1, LEF1, AXIN1, TP53, GADD45A, JUP, BCL2More
Irbesartanhsa05230Central carbon metabolism in cancer4.04E-022P07195, P04637LDHB, TP53More
Irbesartanhsa05231Choline metabolism in cancer3.79E-024O15245, P35790, Q9Y259, P19174SLC22A1, CHKA, CHKB, PLCG1More
Irbesartanhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.82E-0814O95267, P19174, P07766, P20963, P09693, P06239, P23458, P42224, O60603, Q04759, Q16539, P19784, Q9HC35, P01730RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, STAT1, TLR2, PRKCQ, MAPK14, CSNK2A2, EML4, CD4More
Irbesartanhsa05310Asthma2.79E-043P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Irbesartanhsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Irbesartanhsa05321Inflammatory bowel disease2.41E-088O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Irbesartanhsa05322Systemic lupus erythematosus1.69E-089P08311, P0C0L4, P09871, Q93077, P62807, Q16778, O60814, P68431, P12814CTSG, C4A, C1S, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1More
Irbesartanhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Irbesartanhsa05332Graft-versus-host disease5.02E-055P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Irbesartanhsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Irbesartanhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Irbesartanhsa05415Diabetic cardiomyopathy6.60E-0412P17252, P05141, P12236, P14598, Q15080, O15239, Q16718, O14521, P05496, Q13557, P04406, P26678PRKCA, SLC25A5, SLC25A6, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, ATP5G1, CAMK2D, GAPDH, PLNMore
Irbesartanhsa05418Fluid shear stress and atherosclerosis2.18E-0816Q16539, P42338, Q14145, P14598, P78417, P10599, P14780, P01375, P63261, P04637, P10415, P14778, P27930, P0DP23, P08238, Q92974MAPK14, PIK3CB, KEAP1, NCF1, GSTO1, TXN, MMP9, TNF, ACTG1, TP53, BCL2, IL1R1, IL1R2, CALM1, HSP90AB1, ARHGEF2More

Community members of Irbesartan (SDC: 9.57)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Predicted00.32530.5650.15791.4506
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
Q9NZJ5EIF2AK3Eukaryotic translation initiation factor 2Nonealpha kinase 3Predicted10.09390.15740.63981.0015
P13866SLC5A1Sodium/glucose cotransporter 1Predicted00.37190.11050.1050.512
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P40926MDH2Malate dehydrogenase, mitochondrialPredicted00.47210.16110.24740.8055
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P98170BIRC4E3 ubiquitinNoneprotein ligase XIAPPredicted00.29740.22980.791.3984
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
O94782USP1Ubiquitin carboxylNoneterminal hydrolase 1Predicted00.4410.08980.02130.4215
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
O75643ASCC3L1U5 small nuclear ribonucleoprotein 200 kDa helicasePredicted00.24550.03240.2850.4726
P38919EIF4A3Eukaryotic initiation factor 4ANoneIIIPredicted00.36460.03340.48860.7378
P32249GPR183GNoneprotein coupled receptor 183Predicted00.0710.048500.1324
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P18054ALOX12Polyunsaturated fatty acid lipoxygenase ALOX12Predicted00.00750.37030.24160.986
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q13489BIRC3Baculoviral IAP repeatNonecontaining protein 3Predicted00.33620.04930.84721.114
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P78508KCNJ10ATPNonesensitive inward rectifier potassium channel 10Predicted00.07310.08780.20670.4189
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P51684CCR6CNoneC chemokine receptor type 6Predicted00.0850.17410.33040.7212
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P46091GPR1ChemerinNonelike receptor 2Predicted00.24760.137200.3982
P32248CCR7CNoneC chemokine receptor type 7Predicted10.13910.04610.33040.4922
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P43657P2RY5Lysophosphatidic acid receptor 6Predicted00.75390.04480.37080.8373
P32302CXCR5CNoneXNoneC chemokine receptor type 5Predicted00.24550.04590.33040.545
Q99527GPER1GNoneprotein coupled estrogen receptor 1Predicted00.02490.12940.21380.485
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)