| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Ingenol-mebutate | hsa00030 | Pentose phosphate pathway | 1.79E-04 | 3 | P60891, P51854, P37837 | PRPS1, TKTL1, TALDO1 | More | | | Ingenol-mebutate | hsa00100 | Steroid biosynthesis | 3.94E-02 | 1 | P35610 | SOAT1 | More | | | Ingenol-mebutate | hsa00190 | Oxidative phosphorylation | 8.71E-03 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Ingenol-mebutate | hsa00220 | Arginine biosynthesis | 2.64E-04 | 2 | P15104, P49448 | GLUL, GLUD2 | More | | | Ingenol-mebutate | hsa00250 | Alanine, aspartate and glutamate metabolism | 4.40E-03 | 2 | P49448, P15104 | GLUD2, GLUL | More | | | Ingenol-mebutate | hsa00471 | D-Glutamine and D-glutamate metabolism | 3.94E-02 | 1 | P49448 | GLUD2 | More | | | Ingenol-mebutate | hsa00531 | Glycosaminoglycan degradation | 3.78E-02 | 1 | P15586 | GNS | More | | | Ingenol-mebutate | hsa00562 | Inositol phosphate metabolism | 4.13E-03 | 3 | P27987, P19174, P42338 | ITPKB, PLCG1, PIK3CB | More | | | Ingenol-mebutate | hsa00910 | Nitrogen metabolism | 4.40E-03 | 2 | P15104, P49448 | GLUL, GLUD2 | More | | | Ingenol-mebutate | hsa00983 | Drug metabolism - other enzymes | 1.97E-03 | 4 | P04183, P20839, P32320, P05164 | TK1, IMPDH1, CDA, MPO | More | | | Ingenol-mebutate | hsa01100 | Metabolic pathways | 9.60E-03 | 11 | P21953, P15104, P42338, P27987, P53004, P09917, Q9UNP4, P32321, P49448, Q9BPW9, P46976 | BCKDHB, GLUL, PIK3CB, ITPKB, BLVRA, ALOX5, ST3GAL5, DCTD, GLUD2, DHRS9, GYG1 | More | | | Ingenol-mebutate | hsa01230 | Biosynthesis of amino acids | 3.21E-02 | 4 | P51854, P60891, P05089, P37837 | TKTL1, PRPS1, ARG1, TALDO1 | More | | | Ingenol-mebutate | hsa01523 | Antifolate resistance | 3.32E-02 | 3 | P41440, Q92820, P01375 | SLC19A1, GGH, TNF | More | | | Ingenol-mebutate | hsa01524 | Platinum drug resistance | 3.91E-02 | 2 | Q14790, P48023 | CASP8, FASLG | More | | | Ingenol-mebutate | hsa03010 | Ribosome | 7.34E-03 | 6 | P62753, P62829, P62888, P61927, P61513, P36578 | RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4 | More | | | Ingenol-mebutate | hsa03013 | RNA transport | 8.19E-04 | 7 | Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042 | RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2 | More | | | Ingenol-mebutate | hsa03020 | RNA polymerase | 2.51E-02 | 2 | P24928, P62487 | POLR2A, POLR2G | More | | | Ingenol-mebutate | hsa03040 | Spliceosome | 3.98E-02 | 4 | Q15427, P38159, P61978, P11142 | SF3B4, RBMX, HNRPK, HSPA8 | More | | | Ingenol-mebutate | hsa03060 | Protein export | 9.07E-04 | 2 | P37108, Q15005 | SRP14, SPCS2 | More | | | Ingenol-mebutate | hsa04010 | MAPK signaling pathway | 1.53E-02 | 2 | Q9H2K8, Q12933 | TAOK3, TRAF2 | More | | | Ingenol-mebutate | hsa04012 | ErbB signaling pathway | 3.57E-03 | 6 | P21860, Q13191, Q13557, P19174, O14944, P42338 | ERBB3, CBLB, CAMK2D, PLCG1, EREG, PIK3CB | More | | | Ingenol-mebutate | hsa04020 | Calcium signaling pathway | 2.19E-05 | 10 | Q96DU7, Q08828, P45880, Q13557, P21860, P61073, P0DP24, P05141, P51828, P23634 | ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, CXCR4, CALM2, SLC25A5, ADCY7, ATP2B4 | More | | | Ingenol-mebutate | hsa04022 | cGMP-PKG signaling pathway | 2.45E-03 | 8 | Q99941, P18848, P23634, Q08828, P51828, P05141, P45880, P0DP24 | CREBL1, ATF4, ATP2B4, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2 | More | | | Ingenol-mebutate | hsa04024 | cAMP signaling pathway | 9.17E-04 | 2 | Q02930, P15498 | CREB5, VAV1 | More | | | Ingenol-mebutate | hsa04060 | Cytokine-cytokine receptor interaction | 2.09E-02 | 8 | P14784, P14778, Q06643, Q13651, Q9HBE5, P09341, P19875, Q93038 | IL2RB, IL1R1, LTB, IL10RA, IL21R, CXCL1, CXCL2, TNFRSF25 | More | | | Ingenol-mebutate | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 1.91E-02 | 3 | Q8NHW4, P61073, Q13651 | CCL4L2, CXCR4, IL10RA | More | | | Ingenol-mebutate | hsa04062 | Chemokine signaling pathway | 2.94E-02 | 4 | P07948, P42338, P50151, P49407 | LYN, PIK3CB, GNG10, ARRB1 | More | | | Ingenol-mebutate | hsa04064 | NF-kappa B signaling pathway | 7.65E-06 | 21 | P10415, Q13489, O00463, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7 | BCL2, BIRC3, TRAF5, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD | More | | | Ingenol-mebutate | hsa04068 | FoxO signaling pathway | 1.25E-02 | 2 | P48023, Q96BR1 | FASLG, SGK3 | More | | | Ingenol-mebutate | hsa04070 | Phosphatidylinositol signaling system | 3.47E-02 | 4 | P0DP23, Q14643, P23743, P17252 | CALM1, ITPR1, DGKA, PRKCA | More | | | Ingenol-mebutate | hsa04071 | Sphingolipid signaling pathway | 3.68E-04 | 9 | P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q12933, Q02156 | PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, TRAF2, PRKCE | More | | | Ingenol-mebutate | hsa04080 | Neuroactive ligand-receptor interaction | 2.16E-02 | 7 | P08311, Q15722, P21453, Q9H228, P21462, P21730, P07550 | CTSG, LTB4R, S1PR1, EDG8, FPR1, C5AR1, ADRB2 | More | | | Ingenol-mebutate | hsa04114 | Oocyte meiosis | 4.36E-02 | 5 | Q13557, P0DP24, Q08828, P51828, P27348 | CAMK2D, CALM2, ADCY1, ADCY7, YWHAQ | More | | | Ingenol-mebutate | hsa04140 | Autophagy - animal | 1.56E-02 | 4 | Q9Y4H2, P42338, Q9NQL2, Q04759 | IRS2, PIK3CB, RRAGD, PRKCQ | More | | | Ingenol-mebutate | hsa04141 | Protein processing in endoplasmic reticulum | 3.64E-02 | 5 | Q99941, O75460, P11142, Q9H3Z4, P07900 | CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1 | More | | | Ingenol-mebutate | hsa04145 | Phagosome | 1.36E-04 | 11 | O75015, Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765 | FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOB | More | | | Ingenol-mebutate | hsa04151 | PI3K-Akt signaling pathway | 4.50E-02 | 9 | P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252 | F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCA | More | | | Ingenol-mebutate | hsa04152 | AMPK signaling pathway | 4.44E-02 | 1 | Q02930 | CREB5 | More | | | Ingenol-mebutate | hsa04210 | Apoptosis | 1.67E-02 | 3 | Q14790, P48023, P42575 | CASP8, FASLG, CASP2 | More | | | Ingenol-mebutate | hsa04211 | Longevity regulating pathway | 1.21E-02 | 5 | Q08828, P51828, Q99941, P18848, Q02930 | ADCY1, ADCY7, CREBL1, ATF4, CREB5 | More | | | Ingenol-mebutate | hsa04213 | Longevity regulating pathway - multiple species | 1.56E-02 | 4 | P42338, Q9Y4H2, P11142, Q13547 | PIK3CB, IRS2, HSPA8, HDAC1 | More | | | Ingenol-mebutate | hsa04217 | Necroptosis | 1.79E-06 | 16 | P01568, P23458, Q13489, Q9NQC7, P42224, P07900, P15104, P05141, P01584, P0C0S5, Q6FI13, P10415, Q13557, Q9H444, O43633, Q08752 | IFNA21, JAK1, BIRC3, CYLD, STAT1, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, BCL2, CAMK2D, CHMP4B, CHMP2A, PPID | More | | | Ingenol-mebutate | hsa04261 | Adrenergic signaling in cardiomyocytes | 1.49E-04 | 12 | P09493, Q08828, P51828, Q99941, P18848, Q13362, P0DP23, P0DP24, Q13557, P17252, P10415, P23634 | TPM1, ADCY1, ADCY7, CREBL1, ATF4, PPP2R5C, CALM1, CALM2, CAMK2D, PRKCA, BCL2, ATP2B4 | More | | | Ingenol-mebutate | hsa04310 | Wnt signaling pathway | 1.79E-02 | 2 | P17612, P67870 | PRKACA, CSNK2B | More | | | Ingenol-mebutate | hsa04330 | Notch signaling pathway | 4.34E-02 | 2 | Q92542, P46531 | NCSTN, NOTCH1 | More | | | Ingenol-mebutate | hsa04340 | Hedgehog signaling pathway | 3.91E-02 | 1 | P17612 | PRKACA | More | | | Ingenol-mebutate | hsa04360 | Axon guidance | 2.19E-02 | 3 | P42338, O14639, P24844 | PIK3CB, ABLIM1, MYL9 | More | | | Ingenol-mebutate | hsa04370 | VEGF signaling pathway | 4.05E-02 | 2 | P19174, P42338 | PLCG1, PIK3CB | More | | | Ingenol-mebutate | hsa04380 | Osteoclast differentiation | 4.98E-02 | 4 | Q9NQC7, Q9UQC2, P23458, P01584 | CYLD, GAB2, JAK1, IL1B | More | | | Ingenol-mebutate | hsa04540 | Gap junction | 1.29E-02 | 4 | P17252, Q13509, P68371, Q14643 | PRKCA, TUBB3, TUBB2C, ITPR1 | More | | | Ingenol-mebutate | hsa04611 | Platelet activation | 2.12E-02 | 2 | Q9Y490, P17612 | TLN1, PRKACA | More | | | Ingenol-mebutate | hsa04612 | Antigen processing and presentation | 3.30E-05 | 10 | P13765, P48382, P26715, P26717, Q07444, Q13241, P01732, P30101, P11142, P01375 | HLA-DOB, RFX5, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, PDIA3, HSPA8, TNF | More | | | Ingenol-mebutate | hsa04613 | Neutrophil extracellular trap formation | 1.80E-03 | 15 | P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462 | PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1 | More | | | Ingenol-mebutate | hsa04621 | NOD-like receptor signaling pathway | 2.12E-03 | 10 | P01584, P07900, Q14643, P10599, P43490, O00463, P29728, P01375, P09341, P12838 | IL1B, HSP90AA1, ITPR1, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4 | More | | | Ingenol-mebutate | hsa04622 | RIG-I-like receptor signaling pathway | 2.47E-02 | 1 | Q12933 | TRAF2 | More | | | Ingenol-mebutate | hsa04623 | Cytosolic DNA-sensing pathway | 1.20E-02 | 2 | P01584, Q8NHW4 | IL1B, CCL4L2 | More | | | Ingenol-mebutate | hsa04640 | Hematopoietic cell lineage | 1.32E-03 | 10 | P14778, P27930, P11215, P25063, P07766, P09693, P01732, P09564, P13765, P01375 | IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF | More | | | Ingenol-mebutate | hsa04650 | Natural killer cell mediated cytotoxicity | 5.18E-09 | 14 | P19174, P01375, P06239, O60880, P20963, P42338, P15498, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715 | PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, VAV1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P24723 | PRKCH | Protein kinase C eta type | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.767 | | Q04759 | PRKCQ | Protein kinase C theta type | P01375 | TNF | Tumor necrosis factor | -0.725 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P01375 | TNF | Tumor necrosis factor | -0.813 | | Q04759 | PRKCQ | Protein kinase C theta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.779 | | P24723 | PRKCH | Protein kinase C eta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.912 | | Q04759 | PRKCQ | Protein kinase C theta type | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.855 | | P24723 | PRKCH | Protein kinase C eta type | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.835 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.912 | | Q04759 | PRKCQ | Protein kinase C theta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.92 | | P24723 | PRKCH | Protein kinase C eta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.939 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.776 | | P24723 | PRKCH | Protein kinase C eta type | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | P15498 | VAV1 | Proto-oncogene vav | P15498 | VAV1 | Proto-oncogene vav | 1 | | Q04759 | PRKCQ | Protein kinase C theta type | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.849 | | P24723 | PRKCH | Protein kinase C eta type | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.768 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.883 | | Q04759 | PRKCQ | Protein kinase C theta type | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.918 | | P24723 | PRKCH | Protein kinase C eta type | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.822 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.794 | | P24723 | PRKCH | Protein kinase C eta type | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.828 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | -0.704 | | Q04759 | PRKCQ | Protein kinase C theta type | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.803 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.972 | | P24723 | PRKCH | Protein kinase C eta type | Q07444 | KLRC3 | NKG2-E type II integral membrane protein | 0.723 | | Q04759 | PRKCQ | Protein kinase C theta type | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.803 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.972 |
| | Ingenol-mebutate | hsa04657 | IL-17 signaling pathway | 3.33E-03 | 7 | P07900, O00463, P09341, P14780, P80188, P01375, P01584 | HSP90AA1, TRAF5, CXCL1, MMP9, LCN2, TNF, IL1B | More | | | Ingenol-mebutate | hsa04658 | Th1 and Th2 cell differentiation | 9.85E-10 | 12 | Q04759, P07766, P20963, P09693, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761 | PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q04759 | PRKCQ | Protein kinase C theta type | Q04759 | PRKCQ | Protein kinase C theta type | 1 | | P24723 | PRKCH | Protein kinase C eta type | Q04759 | PRKCQ | Protein kinase C theta type | 0.791 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q04759 | PRKCQ | Protein kinase C theta type | 0.755 | | Q04759 | PRKCQ | Protein kinase C theta type | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.713 | | P24723 | PRKCH | Protein kinase C eta type | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.887 | | Q04759 | PRKCQ | Protein kinase C theta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.92 | | P24723 | PRKCH | Protein kinase C eta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.939 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.776 | | Q04759 | PRKCQ | Protein kinase C theta type | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.756 | | P24723 | PRKCH | Protein kinase C eta type | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.767 | | Q04759 | PRKCQ | Protein kinase C theta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.779 | | P24723 | PRKCH | Protein kinase C eta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.912 | | Q04759 | PRKCQ | Protein kinase C theta type | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.746 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.928 | | Q04759 | PRKCQ | Protein kinase C theta type | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.867 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.715 | | Q04759 | PRKCQ | Protein kinase C theta type | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.843 | | P24723 | PRKCH | Protein kinase C eta type | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.856 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.852 | | P24723 | PRKCH | Protein kinase C eta type | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.876 | | Q04759 | PRKCQ | Protein kinase C theta type | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.82 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.76 | | P24723 | PRKCH | Protein kinase C eta type | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.915 |
| | Ingenol-mebutate | hsa04659 | Th17 cell differentiation | 7.86E-08 | 12 | Q04759, P19174, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P07766, P09693, P20963 | PRKCQ, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, CD3E, CD3G, CD247 | More | | | Ingenol-mebutate | hsa04660 | T cell receptor signaling pathway | 3.50E-09 | 14 | P01375, Q04759, P42338, P10747, O95267, Q08881, P19174, P15498, P07766, P20963, P09693, P01732, Q13191, P06239 | TNF, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, VAV1, CD3E, CD247, CD3G, CD8A, CBLB, LCK | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q04759 | PRKCQ | Protein kinase C theta type | P01375 | TNF | Tumor necrosis factor | -0.725 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P01375 | TNF | Tumor necrosis factor | -0.813 | | Q04759 | PRKCQ | Protein kinase C theta type | Q04759 | PRKCQ | Protein kinase C theta type | 1 | | P24723 | PRKCH | Protein kinase C eta type | Q04759 | PRKCQ | Protein kinase C theta type | 0.791 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q04759 | PRKCQ | Protein kinase C theta type | 0.755 | | P24723 | PRKCH | Protein kinase C eta type | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | 0.79 | | Q04759 | PRKCQ | Protein kinase C theta type | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.733 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.754 | | Q04759 | PRKCQ | Protein kinase C theta type | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.803 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.873 | | P24723 | PRKCH | Protein kinase C eta type | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.767 | | P15498 | VAV1 | Proto-oncogene vav | P15498 | VAV1 | Proto-oncogene vav | 1 | | Q04759 | PRKCQ | Protein kinase C theta type | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.713 | | P24723 | PRKCH | Protein kinase C eta type | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.887 | | Q04759 | PRKCQ | Protein kinase C theta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.92 | | P24723 | PRKCH | Protein kinase C eta type | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.939 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.776 | | Q04759 | PRKCQ | Protein kinase C theta type | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.756 | | Q04759 | PRKCQ | Protein kinase C theta type | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.861 | | P24723 | PRKCH | Protein kinase C eta type | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.838 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.812 | | Q04759 | PRKCQ | Protein kinase C theta type | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.767 | | P24723 | PRKCH | Protein kinase C eta type | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.779 | | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.734 | | Q04759 | PRKCQ | Protein kinase C theta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.779 | | P24723 | PRKCH | Protein kinase C eta type | P06239 | LCK | Tyrosine-protein kinase Lck | 0.912 |
| | Ingenol-mebutate | hsa04662 | B cell receptor signaling pathway | 1.23E-04 | 6 | P15498, P42338, P60033, P07948, P21854, Q8N149 | VAV1, PIK3CB, CD81, LYN, CD72, LILRA2 | More | | | Ingenol-mebutate | hsa04664 | Fc epsilon RI signaling pathway | 3.53E-04 | 4 | P42338, P07948, P15498, P09917 | PIK3CB, LYN, VAV1, ALOX5 | More | | | Ingenol-mebutate | hsa04668 | TNF signaling pathway | 1.17E-02 | 4 | Q99941, Q02930, P01584, O95429 | CREBL1, CREB5, IL1B, BAG4 | More | | | Ingenol-mebutate | hsa04670 | Leukocyte transendothelial migration | 3.12E-02 | 1 | P15498 | VAV1 | More | | | Ingenol-mebutate | hsa04672 | Intestinal immune network for IgA production | 3.76E-03 | 3 | P29965, P10747, P13765 | CD40LG, CD28, HLA-DOB | More | | | Ingenol-mebutate | hsa04710 | Circadian rhythm | 4.40E-02 | 1 | O15516 | CLOCK | More | | | Ingenol-mebutate | hsa04713 | Circadian entrainment | 1.25E-03 | 8 | P0DP23, P0DP24, Q13557, P17252, P62873, Q14643, Q08828, P51828 | CALM1, CALM2, CAMK2D, PRKCA, GNB1, ITPR1, ADCY1, ADCY7 | More | | | Ingenol-mebutate | hsa04720 | Long-term potentiation | 1.63E-03 | 7 | P17252, Q13557, P0DP23, P0DP24, P18848, Q08828, Q14643 | PRKCA, CAMK2D, CALM1, CALM2, ATF4, ADCY1, ITPR1 | More | | | Ingenol-mebutate | hsa04722 | Neurotrophin signaling pathway | 9.39E-03 | 2 | Q05655, P52566 | PRKCD, ARHGDIB | More | | | Ingenol-mebutate | hsa04723 | Retrograde endocannabinoid signaling | 1.88E-02 | 4 | Q14643, P17252, P62873, Q16718 | ITPR1, PRKCA, GNB1, NDUFA5 | More | | | Ingenol-mebutate | hsa04725 | Cholinergic synapse | 1.01E-03 | 9 | Q08828, P51828, Q14643, P17252, P62873, P18848, Q02930, Q13557, P10415 | ADCY1, ADCY7, ITPR1, PRKCA, GNB1, ATF4, CREB5, CAMK2D, BCL2 | More | | | Ingenol-mebutate | hsa04727 | GABAergic synapse | 3.63E-02 | 2 | P50151, P15104 | GNG10, GLUL | More | | | Ingenol-mebutate | hsa04728 | Dopaminergic synapse | 2.57E-03 | 10 | Q14643, P17252, P62873, Q99941, P18848, Q13557, Q13362, P0DP23, P0DP24, O15516 | ITPR1, PRKCA, GNB1, CREBL1, ATF4, CAMK2D, PPP2R5C, CALM1, CALM2, CLOCK | More | | | Ingenol-mebutate | hsa04742 | Taste transduction | 3.91E-02 | 1 | P17612 | PRKACA | More | | | Ingenol-mebutate | hsa04744 | Phototransduction | 1.02E-02 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Ingenol-mebutate | hsa04750 | Inflammatory mediator regulation of TRP channels | 3.18E-06 | 10 | P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP24 | IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM2 | More | | | Ingenol-mebutate | hsa04911 | Insulin secretion | 1.11E-05 | 6 | Q08828, P51828, Q99941, P18848, Q02930, Q13557 | ADCY1, ADCY7, CREBL1, ATF4, CREB5, CAMK2D | More | | | Ingenol-mebutate | hsa04912 | GnRH signaling pathway | 5.97E-04 | 8 | P17252, Q08828, P51828, P18848, Q13557, Q14643, P0DP23, P0DP24 | PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, ITPR1, CALM1, CALM2 | More | | | Ingenol-mebutate | hsa04915 | Estrogen signaling pathway | 4.72E-02 | 4 | Q99941, P51828, P07900, P11142 | CREBL1, ADCY7, HSP90AA1, HSPA8 | More | | | Ingenol-mebutate | hsa04916 | Melanogenesis | 7.61E-03 | 4 | Q13557, P0DP24, Q08828, P51828 | CAMK2D, CALM2, ADCY1, ADCY7 | More | | | Ingenol-mebutate | hsa04918 | Thyroid hormone synthesis | 1.66E-03 | 6 | Q08828, P51828, Q99941, P18848, Q02930, P02768 | ADCY1, ADCY7, CREBL1, ATF4, CREB5, ALB | More | | | Ingenol-mebutate | hsa04922 | Glucagon signaling pathway | 1.01E-02 | 5 | Q02930, Q12778, Q13370, P0DP23, Q14643 | CREB5, FOXO1, PDE3B, CALM1, ITPR1 | More | | | Ingenol-mebutate | hsa04924 | Renin secretion | 2.75E-04 | 5 | P22694, P07550, Q14643, Q13370, P0DP23 | PRKACB, ADRB2, ITPR1, PDE3B, CALM1 | More | | | Ingenol-mebutate | hsa04925 | Aldosterone synthesis and secretion | 3.39E-06 | 8 | Q99941, P18848, Q02930, Q08828, P51828, P0DP24, Q13557, P23634 | CREBL1, ATF4, CREB5, ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4 | More | | | Ingenol-mebutate | hsa04926 | Relaxin signaling pathway | 5.54E-03 | 4 | P42338, P50151, Q02930, P49407 | PIK3CB, GNG10, CREB5, ARRB1 | More | | | Ingenol-mebutate | hsa04927 | Cortisol synthesis and secretion | 1.20E-03 | 5 | Q99941, P18848, Q02930, Q08828, P51828 | CREBL1, ATF4, CREB5, ADCY1, ADCY7 | More | | | Ingenol-mebutate | hsa04928 | Parathyroid hormone synthesis, secretion and action | 1.21E-02 | 5 | Q08828, P51828, Q99941, P18848, Q02930 | ADCY1, ADCY7, CREBL1, ATF4, CREB5 | More | | | Ingenol-mebutate | hsa04929 | GnRH secretion | 1.40E-02 | 2 | P42338, P49407 | PIK3CB, ARRB1 | More | | | Ingenol-mebutate | hsa04930 | Type II diabetes mellitus | 9.83E-04 | 2 | Q05655, Q02156 | PRKCD, PRKCE | More | | | Ingenol-mebutate | hsa04931 | Insulin resistance | 2.68E-02 | 1 | Q02930 | CREB5 | More | | | Ingenol-mebutate | hsa04932 | Non-alcoholic fatty liver disease | 2.87E-04 | 7 | Q14790, P18848, P48023, O75460, P01584, P12074, O15239 | CASP8, ATF4, FASLG, ERN1, IL1B, COX6A1, NDUFA1 | More | | | Ingenol-mebutate | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.27E-02 | 5 | P42224, P10415, Q12778, P49767, P17252 | STAT1, BCL2, FOXO1, VEGFC, PRKCA | More | | | Ingenol-mebutate | hsa04934 | Cushing syndrome | 1.56E-06 | 7 | Q99941, P18848, Q02930, Q08828, P51828, O15169, Q13557 | CREBL1, ATF4, CREB5, ADCY1, ADCY7, AXIN1, CAMK2D | More | | | Ingenol-mebutate | hsa04935 | Growth hormone synthesis, secretion and action | 1.80E-02 | 5 | Q08828, P51828, Q99941, P18848, Q02930 | ADCY1, ADCY7, CREBL1, ATF4, CREB5 | More | | | Ingenol-mebutate | hsa04940 | Type I diabetes mellitus | 1.55E-02 | 3 | P10747, P13765, P01375 | CD28, HLA-DOB, TNF | More | | | Ingenol-mebutate | hsa04960 | Aldosterone-regulated sodium reabsorption | 4.40E-02 | 1 | O00141 | SGK | More | | | Ingenol-mebutate | hsa04962 | Vasopressin-regulated water reabsorption | 3.12E-02 | 1 | Q02930 | CREB5 | More | | | Ingenol-mebutate | hsa04966 | Collecting duct acid secretion | 2.86E-02 | 2 | Q13488, Q9Y666 | TCIRG1, SLC12A7 | More | | | Ingenol-mebutate | hsa04970 | Salivary secretion | 1.39E-03 | 7 | P07550, Q08828, P51828, P22694, Q14643, P0DP24, P49913 | ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, CALM2, CAMP | More | | | Ingenol-mebutate | hsa04971 | Gastric acid secretion | 2.95E-05 | 5 | Q08828, P51828, P15311, P0DP24, Q13557 | ADCY1, ADCY7, VIL2, CALM2, CAMK2D | More | | | Ingenol-mebutate | hsa04974 | Protein digestion and absorption | 2.47E-02 | 1 | Q7Z2H8 | SLC36A1 | More | | | Ingenol-mebutate | hsa05010 | Alzheimer disease | 3.93E-05 | 21 | Q92542, O15239, Q16718, O14521, P05496, P12074, Q14643, Q00535, O75460, P0DP23, P0DP24, P01584, P18848, Q13509, P68371, O15169, P05141, P45880, Q08752, P28070, P43686 | NCSTN, NDUFA1, NDUFA5, SDHD, ATP5G1, COX6A1, ITPR1, CDK5, ERN1, CALM1, CALM2, IL1B, ATF4, TUBB3, TUBB2C, AXIN1, SLC25A5, VDAC2, PPID, PSMB4, PSMC4 | More | | | Ingenol-mebutate | hsa05012 | Parkinson disease | 4.70E-04 | 15 | O15239, Q16718, O14521, P12074, P05141, O75460, P18848, P28070, P43686, Q14643, P0DP23, P0DP24, Q13557, Q13509, P68371 | NDUFA1, NDUFA5, SDHD, COX6A1, SLC25A5, ERN1, ATF4, PSMB4, PSMC4, ITPR1, CALM1, CALM2, CAMK2D, TUBB3, TUBB2C | More | | | Ingenol-mebutate | hsa05016 | Huntington disease | 3.54E-02 | 8 | O15239, P12074, P24928, P62487, P05141, O75460, P28070, P43686 | NDUFA1, COX6A1, POLR2A, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4 | More | | | Ingenol-mebutate | hsa05020 | Prion disease | 9.80E-05 | 19 | P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P12074, Q14643, P18848, P05141, P45880, P28070, P43686, Q13509, P68371, Q99941, P14598, Q15080 | IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX6A1, ITPR1, ATF4, SLC25A5, VDAC2, PSMB4, PSMC4, TUBB3, TUBB2C, CREBL1, NCF1, NCF4 | More | | | Ingenol-mebutate | hsa05022 | Pathways of neurodegeneration - multiple diseases | 2.41E-05 | 23 | Q14643, Q13509, P68371, P10415, O15239, Q16718, O14521, P12074, Q8TEV9, O75460, P18848, Q13561, P05141, P17252, Q00535, O15169, P01584, Q08752, P0DP23, P0DP24, Q13557, P28070, P43686 | ITPR1, TUBB3, TUBB2C, BCL2, NDUFA1, NDUFA5, SDHD, COX6A1, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, CDK5, AXIN1, IL1B, PPID, CALM1, CALM2, CAMK2D, PSMB4, PSMC4 | More | | | Ingenol-mebutate | hsa05030 | Cocaine addiction | 9.62E-03 | 4 | Q00535, Q99941, P18848, Q02930 | CDK5, CREBL1, ATF4, CREB5 | More | | | Ingenol-mebutate | hsa05031 | Amphetamine addiction | 2.50E-03 | 5 | P0DP24, Q13557, Q99941, P18848, Q02930 | CALM2, CAMK2D, CREBL1, ATF4, CREB5 | More | | | Ingenol-mebutate | hsa05110 | Vibrio cholerae infection | 2.11E-03 | 2 | Q99437, P17612 | ATP6V0B, PRKACA | More | | | Ingenol-mebutate | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 4.95E-02 | 3 | P09341, P19875, P19174 | CXCL1, CXCL2, PLCG1 | More | | | Ingenol-mebutate | hsa05131 | Shigellosis | 4.98E-04 | 12 | Q12933, P68431, Q05655, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752, P07737 | TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID, PFN1 | More | | | Ingenol-mebutate | hsa05132 | Salmonella infection | 6.68E-03 | 10 | Q9UJU2, P84095, Q13489, P10415, P07737, O60603, Q9BQS8, Q13561, Q13509, P68371 | LEF1, RHOG, BIRC3, BCL2, PFN1, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C | More | | | Ingenol-mebutate | hsa05134 | Legionellosis | 4.88E-03 | 4 | P11215, P11142, P09341, P19875 | ITGAM, HSPA8, CXCL1, CXCL2 | More | | | Ingenol-mebutate | hsa05135 | Yersinia infection | 4.39E-02 | 4 | P06239, P19174, P42338, P01732 | LCK, PLCG1, PIK3CB, CD8A | More | | | Ingenol-mebutate | hsa05140 | Leishmaniasis | 2.17E-03 | 6 | P14598, P42224, P13765, O60603, P29350, Q15080 | NCF1, STAT1, HLA-DOB, TLR2, PTPN6, NCF4 | More | | | Ingenol-mebutate | hsa05142 | Chagas disease | 2.70E-02 | 2 | P48023, Q14790 | FASLG, CASP8 | More | | | Ingenol-mebutate | hsa05145 | Toxoplasmosis | 1.11E-02 | 6 | P10415, Q13489, P42224, P13765, O60603, P29965 | BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG | More | | | Ingenol-mebutate | hsa05146 | Amoebiasis | 2.28E-07 | 11 | P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P22694, P12814, P08311 | CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG | More | | | Ingenol-mebutate | hsa05150 | Staphylococcus aureus infection | 2.66E-03 | 6 | P21730, P21462, O75015, P13765, P12838, P49913 | C5AR1, FPR1, FCGR3B, HLA-DOB, DEFA4, CAMP | More | | | Ingenol-mebutate | hsa05152 | Tuberculosis | 7.93E-04 | 8 | Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8 | TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1 | More | | | Ingenol-mebutate | hsa05163 | Human cytomegalovirus infection | 2.62E-04 | 10 | P0DP24, Q8NHW4, Q08828, P51828, P23458, P01584, P61073, Q13651, Q99941, P18848 | CALM2, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, CXCR4, IL10RA, CREBL1, ATF4 | More | | | Ingenol-mebutate | hsa05165 | Human papillomavirus infection | 3.10E-02 | 8 | P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315 | ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM | More | | | Ingenol-mebutate | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 4.73E-02 | 6 | P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2 | IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1 | More | | | Ingenol-mebutate | hsa05169 | Epstein-Barr virus infection | 3.13E-02 | 9 | P13765, Q13547, O00463, P24522, P01375, P29728, P07766, P09693, P20963 | HLA-DOB, HDAC1, TRAF5, GADD45A, TNF, OAS2, CD3E, CD3G, CD247 | More | | | Ingenol-mebutate | hsa05170 | Human immunodeficiency virus 1 infection | 4.67E-03 | 9 | P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5 | GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2 | More | | | Ingenol-mebutate | hsa05171 | Coronavirus disease - COVID-19 | 3.18E-03 | 7 | P01584, P62753, P36578, P62888, P61927, P61513, P62829 | IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23 | More | | | Ingenol-mebutate | hsa05200 | Pathways in cancer | 4.99E-02 | 12 | P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568 | STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21 | More | | | Ingenol-mebutate | hsa05202 | Transcriptional misregulation in cancer | 5.08E-04 | 14 | Q12778, Q13315, P41732, P14780, P27930, Q15744, Q16548, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P24522 | FOXO1, ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, GADD45A | More | | | Ingenol-mebutate | hsa05206 | MicroRNAs in cancer | 2.97E-03 | 6 | P15311, P21860, P61978, P46531, P63279, P22105 | VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB | More | | | Ingenol-mebutate | hsa05215 | Prostate cancer | 4.00E-02 | 1 | Q02930 | CREB5 | More | | | Ingenol-mebutate | hsa05221 | Acute myeloid leukemia | 4.95E-02 | 3 | P42338, Q15744, P11215 | PIK3CB, CEBPE, ITGAM | More | | | Ingenol-mebutate | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 1.34E-04 | 8 | P42338, O95267, P19174, P07766, P20963, P09693, P06239, Q04759 | PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ | More | | | Ingenol-mebutate | hsa05310 | Asthma | 9.34E-05 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Ingenol-mebutate | hsa05320 | Autoimmune thyroid disease | 1.27E-03 | 4 | P13765, P29965, P01568, P10747 | HLA-DOB, CD40LG, IFNA21, CD28 | More | | | Ingenol-mebutate | hsa05321 | Inflammatory bowel disease | 1.69E-06 | 6 | P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5 | TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R | More | | | Ingenol-mebutate | hsa05322 | Systemic lupus erythematosus | 7.03E-04 | 10 | O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, P68431 | FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Ingenol-mebutate | hsa05323 | Rheumatoid arthritis | 1.18E-04 | 8 | P01375, Q06643, P13765, Q13488, P10747, P09341, P19875, O60603 | TNF, LTB, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2 | More | | | Ingenol-mebutate | hsa05330 | Allograft rejection | 9.93E-04 | 4 | P13765, P29965, P10747, P01375 | HLA-DOB, CD40LG, CD28, TNF | More | | | Ingenol-mebutate | hsa05332 | Graft-versus-host disease | 8.97E-06 | 5 | P13765, P10747, P01375, P26715, Q13241 | HLA-DOB, CD28, TNF, KLRC1, KLRD1 | More | | | Ingenol-mebutate | hsa05340 | Primary immunodeficiency | 4.95E-02 | 3 | P01732, P07766, P06239 | CD8A, CD3E, LCK | More | | | Ingenol-mebutate | hsa05415 | Diabetic cardiomyopathy | 3.55E-02 | 5 | P17252, P14598, Q15080, Q16718, O14521 | PRKCA, NCF1, NCF4, NDUFA5, SDHD | More | | | Ingenol-mebutate | hsa05416 | Viral myocarditis | 2.62E-02 | 3 | P13765, P29965, P10747 | HLA-DOB, CD40LG, CD28 | More | |
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