| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Indomethacin | hsa00030 | Pentose phosphate pathway | 3.06E-04 | 3 | P60891, P51854, P37837 | PRPS1, TKTL1, TALDO1 | More | | | Indomethacin | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Indomethacin | hsa00190 | Oxidative phosphorylation | 8.12E-04 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Indomethacin | hsa00220 | Arginine biosynthesis | 1.94E-03 | 3 | P15104, P05089, P49448 | GLUL, ARG1, GLUD2 | More | | | Indomethacin | hsa00230 | Purine metabolism | 1.81E-02 | 2 | P20839, Q02153 | IMPDH1, GUCY1B3 | More | | | Indomethacin | hsa00240 | Pyrimidine metabolism | 4.29E-02 | 2 | P21589, P04183 | NT5E, TK1 | More | | | Indomethacin | hsa00250 | Alanine, aspartate and glutamate metabolism | 4.32E-02 | 2 | P49448, P15104 | GLUD2, GLUL | More | | | Indomethacin | hsa00260 | Glycine, serine and threonine metabolism | 1.99E-02 | 1 | P22557 | ALAS2 | More | | | Indomethacin | hsa00310 | Lysine degradation | 4.24E-05 | 3 | Q96KQ7, Q02809, P51648 | EHMT2, PLOD1, ALDH3A2 | More | | | Indomethacin | hsa00480 | Glutathione metabolism | 3.29E-04 | 4 | Q9UJ14, Q16772, P09211, P30041 | GGTL3, GSTA3, GSTP1, PRDX6 | More | | | Indomethacin | hsa00500 | Starch and sucrose metabolism | 1.42E-03 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Indomethacin | hsa00510 | N-Glycan biosynthesis | 1.00E-02 | 2 | O94777, Q9BVK2 | DPM2, ALG8 | More | | | Indomethacin | hsa00512 | Mucin type O-glycan biosynthesis | 3.19E-03 | 3 | O95395, Q8N4A0, Q9NY28 | GCNT3, GALNT4, GALNT8 | More | | | Indomethacin | hsa00513 | Various types of N-glycan biosynthesis | 4.96E-02 | 1 | Q9NR34 | MAN1C1 | More | | | Indomethacin | hsa00515 | Mannose type O-glycan biosynthesis | 4.96E-02 | 1 | O75072 | FCMD | More | | | Indomethacin | hsa00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 1.91E-02 | 1 | Q9NY97 | B3GNT2 | More | | | Indomethacin | hsa00561 | Glycerolipid metabolism | 1.49E-03 | 4 | P51648, P14550, P23743, Q86XP1 | ALDH3A2, AKR1A1, DGKA, DGKH | More | | | Indomethacin | hsa00562 | Inositol phosphate metabolism | 7.30E-04 | 4 | P27987, Q96PE3, P19174, P42338 | ITPKB, INPP4A, PLCG1, PIK3CB | More | | | Indomethacin | hsa00563 | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 3.47E-03 | 2 | O94777, Q14442 | DPM2, PIGH | More | | | Indomethacin | hsa00564 | Glycerophospholipid metabolism | 4.29E-02 | 2 | Q6P1A2, P23743 | MBOAT5, DGKA | More | | | Indomethacin | hsa00565 | Ether lipid metabolism | 1.44E-05 | 2 | Q9Y6K0, Q8N661 | CEPT1, TMEM86B | More | | | Indomethacin | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Indomethacin | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Indomethacin | hsa00600 | Sphingolipid metabolism | 4.47E-02 | 2 | Q96G23, Q86VZ5 | LASS2, SGMS1 | More | | | Indomethacin | hsa00601 | Glycosphingolipid biosynthesis - lacto and neolacto series | 3.78E-02 | 1 | Q9NY97 | B3GNT2 | More | | | Indomethacin | hsa00620 | Pyruvate metabolism | 7.73E-05 | 4 | P40925, P40926, P51648, P14550 | MDH1, MDH2, ALDH3A2, AKR1A1 | More | | | Indomethacin | hsa00630 | Glyoxylate and dicarboxylate metabolism | 3.33E-10 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Indomethacin | hsa00670 | One carbon pool by folate | 3.15E-02 | 2 | O95954, Q99707 | FTCD, MTR | More | | | Indomethacin | hsa00730 | Thiamine metabolism | 2.54E-03 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Indomethacin | hsa00860 | Porphyrin and chlorophyll metabolism | 3.15E-02 | 2 | P36551, P30043 | CPOX, BLVRB | More | | | Indomethacin | hsa00910 | Nitrogen metabolism | 4.32E-02 | 2 | P15104, P49448 | GLUL, GLUD2 | More | | | Indomethacin | hsa00920 | Sulfur metabolism | 4.01E-04 | 1 | Q16762 | TST | More | | | Indomethacin | hsa00970 | Aminoacyl-tRNA biosynthesis | 3.78E-02 | 2 | O95363, Q15046 | FARS2, KARS | More | | | Indomethacin | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-05 | 4 | Q16772, P78417, P09211, P11712 | GSTA3, GSTO1, GSTP1, CYP2C9 | More | | | Indomethacin | hsa00982 | Drug metabolism - cytochrome P450 | 1.77E-04 | 4 | P11712, Q16772, P09211, P78417 | CYP2C9, GSTA3, GSTP1, GSTO1 | More | | | Indomethacin | hsa00983 | Drug metabolism - other enzymes | 1.72E-02 | 2 | Q16772, P09211 | GSTA3, GSTP1 | More | | | Indomethacin | hsa01100 | Metabolic pathways | 5.59E-06 | 36 | Q9Y234, P35790, Q16772, P09211, Q9UJ14, P30041, P15104, P51648, P42338, Q96PE3, P19174, P27987, Q6ZQY3, Q13370, P20839, P40925, P40926, O94777, Q7KZN9, Q9Y6K0, P15121, P23743, Q86XP1, P14550, Q9UHK6, P43034, Q86VZ5, Q96G23, P09917, Q9BVK2, Q14442, Q53FZ2, Q9BQB6, Q06055, Q99437, Q9NVH6 | LIPT1, CHKA, GSTA3, GSTP1, GGTL3, PRDX6, GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, GADL1, PDE3B, IMPDH1, MDH1, MDH2, DPM2, COX15, CEPT1, AKR1B1, DGKA, DGKH, AKR1A1, AMACR, PAFAH1B1, SGMS1, LASS2, ALOX5, ALG8, PIGH, ACSM3, VKORC1, ATP5G2, ATP6V0B, TMLHE | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P10145 | IL8 | Interleukin-8 | Q9Y234 | LIPT1 | Lipoyltransferase 1, mitochondrial | 0.766 | | P15121 | AKR1B1 | Aldo-keto reductase family 1 member B1 | P35790 | CHKA | Choline kinase alpha | -0.717 | | P15121 | AKR1B1 | Aldo-keto reductase family 1 member B1 | Q16772 | GSTA3 | Glutathione S-transferase A3 | -0.793 | | P15121 | AKR1B1 | Aldo-keto reductase family 1 member B1 | P09211 | GSTP1 | Glutathione S-transferase P | 0.712 | | P15121 | AKR1B1 | Aldo-keto reductase family 1 member B1 | Q9UJ14 | GGTL3 | Glutathione hydrolase 7 | 0.748 | | P15121 | AKR1B1 | Aldo-keto reductase family 1 member B1 | P30041 | PRDX6 | Peroxiredoxin-6 | 0.75 | | P06746 | POLB | DNA polymerase beta | P15104 | GLUL | Glutamine synthetase | -0.71 | | P06746 | POLB | DNA polymerase beta | P51648 | ALDH3A2 | Aldehyde dehydrogenase family 3 member A2 | 0.845 | | P06746 | POLB | DNA polymerase beta | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.74 | | P06746 | POLB | DNA polymerase beta | Q96PE3 | INPP4A | Inositol polyphosphate-4-phosphatase type I A | 0.711 | | P06746 | POLB | DNA polymerase beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.787 | | P06746 | POLB | DNA polymerase beta | P27987 | ITPKB | Inositol-trisphosphate 3-kinase B | 0.835 | | P10145 | IL8 | Interleukin-8 | Q6ZQY3 | GADL1 | Acidic amino acid decarboxylase GADL1 | 0.753 | | P06746 | POLB | DNA polymerase beta | Q13370 | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | -0.758 | | P10145 | IL8 | Interleukin-8 | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | 0.764 | | P06746 | POLB | DNA polymerase beta | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | 0.837 | | P15121 | AKR1B1 | Aldo-keto reductase family 1 member B1 | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | 0.81 | | P10145 | IL8 | Interleukin-8 | O94777 | DPM2 | Dolichol phosphate-mannose biosynthesis regulatory protein | 0.757 | | P15121 | AKR1B1 | Aldo-keto reductase family 1 member B1 | Q7KZN9 | COX15 | Cytochrome c oxidase assembly protein COX15 homolog | 0.764 | | P10145 | IL8 | Interleukin-8 | Q9Y6K0 | CEPT1 | Choline/ethanolaminephosphotransferase 1 | 0.758 | | P15121 | AKR1B1 | Aldo-keto reductase family 1 member B1 | P15121 | AKR1B1 | Aldo-keto reductase family 1 member B1 | 1 | | P06746 | POLB | DNA polymerase beta | P23743 | DGKA | Diacylglycerol kinase alpha | 0.814 | | P10145 | IL8 | Interleukin-8 | Q86XP1 | DGKH | Diacylglycerol kinase eta | -0.805 | | P10145 | IL8 | Interleukin-8 | P14550 | AKR1A1 | Aldo-keto reductase family 1 member A1 | 0.723 | | P15121 | AKR1B1 | Aldo-keto reductase family 1 member B1 | Q9UHK6 | AMACR | Alpha-methylacyl-CoA racemase | -0.704 | | P10145 | IL8 | Interleukin-8 | Q9UHK6 | AMACR | Alpha-methylacyl-CoA racemase | -0.744 | | P06746 | POLB | DNA polymerase beta | P43034 | PAFAH1B1 | Platelet-activating factor acetylhydrolase IB subunit beta | 0.726 | | P15121 | AKR1B1 | Aldo-keto reductase family 1 member B1 | Q86VZ5 | SGMS1 | Phosphatidylcholine:ceramide cholinephosphotransferase 1 | -0.736 | | P10145 | IL8 | Interleukin-8 | Q86VZ5 | SGMS1 | Phosphatidylcholine:ceramide cholinephosphotransferase 1 | -0.758 | | P10145 | IL8 | Interleukin-8 | Q96G23 | LASS2 | Ceramide synthase 2 | -0.796 | | P06746 | POLB | DNA polymerase beta | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | -0.789 | | P10145 | IL8 | Interleukin-8 | Q9BVK2 | ALG8 | Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase | -0.844 | | P10145 | IL8 | Interleukin-8 | Q14442 | PIGH | Phosphatidylinositol N-acetylglucosaminyltransferase subunit H | -0.752 | | P06746 | POLB | DNA polymerase beta | Q53FZ2 | ACSM3 | Acyl-coenzyme A synthetase ACSM3, mitochondrial | -0.744 | | P15121 | AKR1B1 | Aldo-keto reductase family 1 member B1 | Q9BQB6 | VKORC1 | Vitamin K epoxide reductase complex subunit 1 | 0.731 | | P10145 | IL8 | Interleukin-8 | Q06055 | ATP5G2 | ATP synthase F(0) complex subunit C2, mitochondrial | -0.753 | | P10145 | IL8 | Interleukin-8 | Q99437 | ATP6V0B | V-type proton ATPase 21 kDa proteolipid subunit c'' | 0.732 | | P10145 | IL8 | Interleukin-8 | Q9NVH6 | TMLHE | Trimethyllysine dioxygenase, mitochondrial | -0.73 |
| | Indomethacin | hsa01200 | Carbon metabolism | 4.32E-02 | 3 | P51854, P37837, P60891 | TKTL1, TALDO1, PRPS1 | More | | | Indomethacin | hsa01210 | 2-Oxocarboxylic acid metabolism | 2.63E-04 | 1 | P50213 | IDH3A | More | | | Indomethacin | hsa01230 | Biosynthesis of amino acids | 2.60E-02 | 3 | P51854, P60891, P37837 | TKTL1, PRPS1, TALDO1 | More | | | Indomethacin | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 2.46E-04 | 5 | Q92529, P19174, P42338, P08069, Q9NRA1 | SHC3, PLCG1, PIK3CB, IGF1R, PDGFC | More | | | Indomethacin | hsa01522 | Endocrine resistance | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Indomethacin | hsa01524 | Platinum drug resistance | 8.70E-04 | 7 | P10415, Q13489, Q16772, P09211, P78417, P23025, P43246 | BCL2, BIRC3, GSTA3, GSTP1, GSTO1, XPA, MSH2 | More | | | Indomethacin | hsa02010 | ABC transporters | 2.17E-03 | 1 | Q8IZY2 | ABCA7 | More | | | Indomethacin | hsa03008 | Ribosome biogenesis in eukaryotes | 2.52E-02 | 3 | P78345, O15381, Q9GZY0 | RPP38, NVL, NXF2; NXF2B | More | | | Indomethacin | hsa03010 | Ribosome | 1.88E-02 | 6 | P62753, P25398, P32969, P62829, P18077, P36578 | RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4 | More | | | Indomethacin | hsa03013 | RNA transport | 5.40E-10 | 21 | O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, O75822, P78345, P20042, Q14240, Q9Y6A5, Q06787, P51114 | XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF4A2, TACC3, FMR1, FXR1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q9UBU7 | DBF4 | Protein DBF4 homolog A | O14980 | XPO1 | Exportin-1 | 0.943 | | P21462 | FPR1 | fMet-Leu-Phe receptor | O14980 | XPO1 | Exportin-1 | -0.742 | | P08246 | ELA2 | Neutrophil elastase | P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | -0.852 | | P22748 | CA4 | Carbonic anhydrase 4 | P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | -0.879 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | 0.888 | | P21462 | FPR1 | fMet-Leu-Phe receptor | P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | -0.874 | | P08246 | ELA2 | Neutrophil elastase | Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | -0.732 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | 0.742 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | 0.742 | | P21462 | FPR1 | fMet-Leu-Phe receptor | Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | -0.78 | | P08246 | ELA2 | Neutrophil elastase | O14893 | GEMIN2 | Gem-associated protein 2 | -0.785 | | P22748 | CA4 | Carbonic anhydrase 4 | O14893 | GEMIN2 | Gem-associated protein 2 | -0.709 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O14893 | GEMIN2 | Gem-associated protein 2 | 0.853 | | P21462 | FPR1 | fMet-Leu-Phe receptor | O14893 | GEMIN2 | Gem-associated protein 2 | -0.87 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | P61326 | MAGOH | Protein mago nashi homolog | 0.737 | | P22748 | CA4 | Carbonic anhydrase 4 | P61326 | MAGOH | Protein mago nashi homolog | -0.822 | | P21462 | FPR1 | fMet-Leu-Phe receptor | P61326 | MAGOH | Protein mago nashi homolog | -0.835 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Q15287 | RNPS1 | RNA-binding protein with serine-rich domain 1 | 0.756 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Q9UBU9 | NXF1 | Nuclear RNA export factor 1 | 0.723 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | Q9H307 | PNN | Pinin | 0.722 | | P08246 | ELA2 | Neutrophil elastase | Q7Z3B4 | NUP54 | Nucleoporin p54 | -0.723 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | Q7Z3B4 | NUP54 | Nucleoporin p54 | 0.787 | | P22748 | CA4 | Carbonic anhydrase 4 | Q7Z3B4 | NUP54 | Nucleoporin p54 | -0.776 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q7Z3B4 | NUP54 | Nucleoporin p54 | 0.774 | | P21462 | FPR1 | fMet-Leu-Phe receptor | Q7Z3B4 | NUP54 | Nucleoporin p54 | -0.903 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P35658 | NUP214 | Nuclear pore complex protein Nup214 | -0.725 | | P08246 | ELA2 | Neutrophil elastase | P35658 | NUP214 | Nuclear pore complex protein Nup214 | 0.765 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | P35658 | NUP214 | Nuclear pore complex protein Nup214 | -0.781 | | P22748 | CA4 | Carbonic anhydrase 4 | P35658 | NUP214 | Nuclear pore complex protein Nup214 | 0.827 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35658 | NUP214 | Nuclear pore complex protein Nup214 | -0.751 | | P21462 | FPR1 | fMet-Leu-Phe receptor | P35658 | NUP214 | Nuclear pore complex protein Nup214 | 0.971 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.736 | | P08246 | ELA2 | Neutrophil elastase | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | -0.722 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | 0.902 | | P22748 | CA4 | Carbonic anhydrase 4 | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | -0.786 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | 0.734 | | P21462 | FPR1 | fMet-Leu-Phe receptor | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | -0.89 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P55884 | EIF3B | Eukaryotic translation initiation factor 3 subunit B | -0.731 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | O15371 | EIF3D | Eukaryotic translation initiation factor 3 subunit D | 0.77 | | P08246 | ELA2 | Neutrophil elastase | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | -0.825 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | 0.83 | | P22748 | CA4 | Carbonic anhydrase 4 | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | -0.869 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | 0.837 | | P21462 | FPR1 | fMet-Leu-Phe receptor | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | -0.953 | | P08246 | ELA2 | Neutrophil elastase | P78345 | RPP38 | Ribonuclease P protein subunit p38 | -0.795 | | P22748 | CA4 | Carbonic anhydrase 4 | P78345 | RPP38 | Ribonuclease P protein subunit p38 | -0.731 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P78345 | RPP38 | Ribonuclease P protein subunit p38 | 0.852 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P20042 | EIF2S2 | Eukaryotic translation initiation factor 2 subunit 2 | 0.733 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | Q14240 | EIF4A2 | Eukaryotic initiation factor 4A-II | 0.867 | | P21462 | FPR1 | fMet-Leu-Phe receptor | Q14240 | EIF4A2 | Eukaryotic initiation factor 4A-II | -0.721 | | P08246 | ELA2 | Neutrophil elastase | Q9Y6A5 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | 0.849 | | P22748 | CA4 | Carbonic anhydrase 4 | Q9Y6A5 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | 0.912 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9Y6A5 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | -0.812 | | P21462 | FPR1 | fMet-Leu-Phe receptor | Q9Y6A5 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | 0.904 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | Q06787 | FMR1 | Synaptic functional regulator FMR1 | 0.772 | | Q9UBU7 | DBF4 | Protein DBF4 homolog A | P51114 | FXR1 | Fragile X mental retardation syndrome-related protein 1 | 0.854 | | P21462 | FPR1 | fMet-Leu-Phe receptor | P51114 | FXR1 | Fragile X mental retardation syndrome-related protein 1 | -0.713 |
| | Indomethacin | hsa03020 | RNA polymerase | 3.59E-02 | 2 | P30876, P62487 | POLR2B, POLR2G | More | | | Indomethacin | hsa03030 | DNA replication | 5.00E-02 | 1 | P27694 | RPA1 | More | | | Indomethacin | hsa03040 | Spliceosome | 4.09E-13 | 19 | Q14562, O43143, O60508, Q99633, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, Q9UMS4, P11142, Q9Y2W2, O43447, O75643 | DHX8, DHX15, CDC40, PRPF18, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, PRPF19, HSPA8, WBP11, PPIH, ASCC3L1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P29375 | JARID1A | Lysine-specific demethylase 5A | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.781 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.775 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | -0.819 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.794 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.871 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.76 | | P46091 | GPR1 | Chemerin-like receptor 2 | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.816 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.875 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.716 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.812 | | O15529 | GPR42 | G-protein coupled receptor 42 | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.728 | | P46091 | GPR1 | Chemerin-like receptor 2 | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.778 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q99633 | PRPF18 | Pre-mRNA-splicing factor 18 | -0.711 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.822 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Q15427 | SF3B4 | Splicing factor 3B subunit 4 | 0.71 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.751 | | O15529 | GPR42 | G-protein coupled receptor 42 | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.867 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P38159 | RBMX | RNA-binding motif protein, X chromosome | 0.733 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P61978 | HNRPK | Heterogeneous nuclear ribonucleoprotein K | 0.784 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.74 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.753 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.827 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.749 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.783 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.798 | | O15529 | GPR42 | G-protein coupled receptor 42 | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.731 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.746 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.773 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.943 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.822 | | O15529 | GPR42 | G-protein coupled receptor 42 | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.747 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q9UMS4 | PRPF19 | Pre-mRNA-processing factor 19 | 0.703 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.876 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.766 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.802 | | O15529 | GPR42 | G-protein coupled receptor 42 | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.738 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | -0.743 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.766 | | O15529 | GPR42 | G-protein coupled receptor 42 | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.706 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | -0.745 |
| | Indomethacin | hsa03050 | Proteasome | 4.83E-02 | 1 | P55036 | PSMD4 | More | | | Indomethacin | hsa03060 | Protein export | 5.99E-04 | 4 | Q15070, P37108, O76094, Q15005 | OXA1L, SRP14, SRP72, SPCS2 | More | | | Indomethacin | hsa03450 | Non-homologous end-joining | 4.96E-02 | 1 | Q9NP87 | POLM | More | | | Indomethacin | hsa04010 | MAPK signaling pathway | 4.15E-02 | 1 | P08069 | IGF1R | More | | | Indomethacin | hsa04012 | ErbB signaling pathway | 8.47E-05 | 8 | P21860, P16333, Q92529, Q13557, P19174, O14944, P42338, P01106 | ERBB3, NCK1, SHC3, CAMK2D, PLCG1, EREG, PIK3CB, MYC | More | | | Indomethacin | hsa04014 | Ras signaling pathway | 1.22E-06 | 13 | P42338, Q92529, P20827, Q9NRA1, P49767, P08069, Q13009, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174 | PIK3CB, SHC3, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1 | More | | | Indomethacin | hsa04015 | Rap1 signaling pathway | 4.11E-06 | 16 | P20827, Q9NRA1, P49767, P08069, P63261, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P0DP23, P08514, P17252, P19174 | EFNA1, PDGFC, VEGFC, IGF1R, ACTG1, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, CALM1, ITGA2B, PRKCA, PLCG1 | More | | | Indomethacin | hsa04020 | Calcium signaling pathway | 2.25E-07 | 15 | P27987, Q96DU7, P45880, Q16566, Q13557, P17252, P21860, O15399, P19174, P25116, P0DP23, P51828, P23634, Q9NRA1, P49767 | ITPKB, ITPKC, VDAC2, CAMK4, CAMK2D, PRKCA, ERBB3, GRIN2D, PLCG1, F2R, CALM1, ADCY7, ATP2B4, PDGFC, VEGFC | More | | | Indomethacin | hsa04022 | cGMP-PKG signaling pathway | 4.72E-02 | 4 | Q99941, P23634, P51828, P45880 | CREBL1, ATP2B4, ADCY7, VDAC2 | More | | | Indomethacin | hsa04024 | cAMP signaling pathway | 3.34E-03 | 8 | P42338, P0DP23, P23634, Q16566, Q13370, O15399, P25116, Q13009 | PIK3CB, CALM1, ATP2B4, CAMK4, PDE3B, GRIN2D, F2R, TIAM1 | More | | | Indomethacin | hsa04062 | Chemokine signaling pathway | 2.26E-07 | 19 | P25024, P25025, P09769, P07948, P42338, P19174, Q92529, P62873, P63218, P50151, P43250, P49407, Q7LDG7, Q13009, P14598, P42224, P25963, P49841, Q8WYR1 | CXCR1, CXCR2, FGR, LYN, PIK3CB, PLCG1, SHC3, GNB1, GNG5, GNG10, GRK6, ARRB1, RASGRP2, TIAM1, NCF1, STAT1, NFKBIA, GSK3B, PIK3R5 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | 0.909 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.86 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P09769 | FGR | Tyrosine-protein kinase Fgr | 0.796 | | P06746 | POLB | DNA polymerase beta | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.804 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.782 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.795 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.971 | | P06746 | POLB | DNA polymerase beta | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.74 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.751 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P06746 | POLB | DNA polymerase beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.787 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P06746 | POLB | DNA polymerase beta | Q92529 | SHC3 | SHC-transforming protein 3 | -0.785 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | P06746 | POLB | DNA polymerase beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.736 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.733 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P06746 | POLB | DNA polymerase beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.804 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.875 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43250 | GRK6 | G protein-coupled receptor kinase 6 | 0.818 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P49407 | ARRB1 | Beta-arrestin-1 | -0.853 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.746 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.785 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.812 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 |
| | Indomethacin | hsa04064 | NF-kappa B signaling pathway | 5.59E-07 | 14 | P10415, Q13489, P25963, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, Q13315, P24522, P09341 | BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, ATM, GADD45A, CXCL1 | More | | | Indomethacin | hsa04066 | HIF-1 signaling pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Indomethacin | hsa04068 | FoxO signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Indomethacin | hsa04070 | Phosphatidylinositol signaling system | 9.31E-06 | 6 | P19174, P0DP23, P42338, P23743, Q96PE3, P27987 | PLCG1, CALM1, PIK3CB, DGKA, INPP4A, ITPKB | More | | | Indomethacin | hsa04071 | Sphingolipid signaling pathway | 2.70E-10 | 9 | P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2 | PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q15722 | LTB4R | Leukotriene B4 receptor 1 | P17252 | PRKCA | Protein kinase C alpha type | -0.757 | | P08246 | ELA2 | Neutrophil elastase | P17252 | PRKCA | Protein kinase C alpha type | -0.735 | | P21462 | FPR1 | fMet-Leu-Phe receptor | P17252 | PRKCA | Protein kinase C alpha type | -0.731 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | 0.934 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | -0.832 | | P08246 | ELA2 | Neutrophil elastase | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | -0.725 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P21453 | S1PR1 | Sphingosine 1-phosphate receptor 1 | 0.704 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | 0.777 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.841 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.733 | | P08246 | ELA2 | Neutrophil elastase | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.797 | | P22748 | CA4 | Carbonic anhydrase 4 | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.814 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | 0.809 | | P21462 | FPR1 | fMet-Leu-Phe receptor | Q9H228 | EDG8 | Sphingosine 1-phosphate receptor 5 | -0.716 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P01375 | TNF | Tumor necrosis factor | 0.759 | | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | | P22748 | CA4 | Carbonic anhydrase 4 | P01375 | TNF | Tumor necrosis factor | 0.744 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P01375 | TNF | Tumor necrosis factor | -0.755 | | P21462 | FPR1 | fMet-Leu-Phe receptor | P01375 | TNF | Tumor necrosis factor | 0.77 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.721 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.716 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.773 | | P08246 | ELA2 | Neutrophil elastase | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.865 | | P22748 | CA4 | Carbonic anhydrase 4 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.758 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.712 | | P21462 | FPR1 | fMet-Leu-Phe receptor | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | -0.878 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | 0.7 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.781 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.884 | | P08246 | ELA2 | Neutrophil elastase | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.847 | | P22748 | CA4 | Carbonic anhydrase 4 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.88 | | P21462 | FPR1 | fMet-Leu-Phe receptor | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.932 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.721 | | P22748 | CA4 | Carbonic anhydrase 4 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.767 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.713 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.766 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.865 | | P08246 | ELA2 | Neutrophil elastase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.942 | | P22748 | CA4 | Carbonic anhydrase 4 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.863 | | P21462 | FPR1 | fMet-Leu-Phe receptor | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.855 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9UQC2 | GAB2 | GRB2-associated-binding protein 2 | 0.822 |
| | Indomethacin | hsa04072 | Phospholipase D signaling pathway | 1.85E-04 | 6 | P42338, Q92529, P19174, Q14344, P23743, Q9NRA1 | PIK3CB, SHC3, PLCG1, GNA13, DGKA, PDGFC | More | | | Indomethacin | hsa04080 | Neuroactive ligand-receptor interaction | 3.78E-06 | 11 | P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550, P35318 | CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2, ADM | More | | | Indomethacin | hsa04110 | Cell cycle | 1.44E-02 | 7 | P06493, O75293, P30304, P33981, P42773, P01106, Q13547 | CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1 | More | | | Indomethacin | hsa04114 | Oocyte meiosis | 2.99E-02 | 1 | P08069 | IGF1R | More | | | Indomethacin | hsa04115 | p53 signaling pathway | 3.57E-02 | 5 | P24522, Q13315, Q53FA7, O95067, P10415 | GADD45A, ATM, TP53I3, CCNB2, BCL2 | More | | | Indomethacin | hsa04120 | Ubiquitin mediated proteolysis | 3.55E-03 | 4 | Q13042, Q15751, O95071, P0CG47 | CDC16, HERC1, UBR5, UBB | More | | | Indomethacin | hsa04122 | Sulfur relay system | 4.01E-04 | 1 | Q16762 | TST | More | | | Indomethacin | hsa04136 | Autophagy - other | 3.53E-02 | 1 | O94817 | ATG12 | More | | | Indomethacin | hsa04137 | Mitophagy - animal | 9.52E-03 | 2 | Q07817, P0CG47 | BCL2L1, UBB | More | | | Indomethacin | hsa04140 | Autophagy - animal | 2.95E-02 | 5 | P08069, P22694, Q14643, P10415, Q04759 | IGF1R, PRKACB, ITPR1, BCL2, PRKCQ | More | | | Indomethacin | hsa04141 | Protein processing in endoplasmic reticulum | 1.09E-05 | 12 | P18848, P30101, O60337, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9H173, Q9UNL2 | ATF4, PDIA3, MARH6, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SIL1, SSR3 | More | | | Indomethacin | hsa04145 | Phagosome | 3.39E-09 | 14 | O75015, P11215, P63261, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, O60603, P35443, P27824, P13765 | FCGR3B, ITGAM, ACTG1, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, CANX, HLA-DOB | More | | | Indomethacin | hsa04146 | Peroxisome | 2.42E-02 | 5 | O43933, P56589, Q9UKG9, O75521, P33121 | PEX1, PEX3, CROT, ECI2, ACSL1 | More | | | Indomethacin | hsa04150 | mTOR signaling pathway | 2.47E-02 | 5 | P08069, P42338, Q9NQL2, Q13322, P49841 | IGF1R, PIK3CB, RRAGD, GRB10, GSK3B | More | | | Indomethacin | hsa04151 | PI3K-Akt signaling pathway | 7.72E-04 | 13 | P42338, P43657, P20827, Q9NRA1, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281 | PIK3CB, P2RY5, EFNA1, PDGFC, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3 | More | | | Indomethacin | hsa04152 | AMPK signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Indomethacin | hsa04210 | Apoptosis | 1.54E-03 | 11 | Q13315, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, Q14643 | ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ITPR1 | More | | | Indomethacin | hsa04211 | Longevity regulating pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Indomethacin | hsa04213 | Longevity regulating pathway - multiple species | 1.66E-02 | 1 | P08069 | IGF1R | More | | | Indomethacin | hsa04217 | Necroptosis | 7.72E-06 | 14 | P01568, Q13489, P42224, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q93077, Q13557, O43633, Q08752 | IFNA21, BIRC3, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, HIST1H2AC, CAMK2D, CHMP2A, PPID | More | | | Indomethacin | hsa04261 | Adrenergic signaling in cardiomyocytes | 3.03E-03 | 8 | P07550, P51828, P22694, Q99941, P18848, Q13362, Q13557, P23634 | ADRB2, ADCY7, PRKACB, CREBL1, ATF4, PPP2R5C, CAMK2D, ATP2B4 | More | | | Indomethacin | hsa04330 | Notch signaling pathway | 2.70E-03 | 4 | Q92542, P49768, P78504, P46531 | NCSTN, PSEN1, JAG1, NOTCH1 | More | | | Indomethacin | hsa04340 | Hedgehog signaling pathway | 1.05E-03 | 4 | P49841, P22694, Q13635, P10415 | GSK3B, PRKACB, PTCH1, BCL2 | More | | | Indomethacin | hsa04350 | TGF-beta signaling pathway | 4.88E-02 | 1 | P37173 | TGFBR2 | More | | | Indomethacin | hsa04360 | Axon guidance | 2.47E-03 | 7 | P16333, P20827, O95631, P42338, P07332, P23528, P19174 | NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1 | More | | | Indomethacin | hsa04370 | VEGF signaling pathway | 1.56E-02 | 2 | P19174, P42338 | PLCG1, PIK3CB | More | | | Indomethacin | hsa04371 | Apelin signaling pathway | 1.71E-06 | 10 | P62873, P63218, P50151, Q8WYR1, Q13370, Q14814, Q14344, Q13485, P84022, P0DP23 | GNB1, GNG5, GNG10, PIK3R5, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CALM1 | More | | | Indomethacin | hsa04380 | Osteoclast differentiation | 4.71E-02 | 6 | Q16539, P06239, P42338, P14778, O75015, Q8N149 | MAPK14, LCK, PIK3CB, IL1R1, FCGR3B, LILRA2 | More | | | Indomethacin | hsa04390 | Hippo signaling pathway | 2.11E-03 | 6 | P63261, Q13485, O15105, Q9UJU2, O43623, Q13489 | ACTG1, SMAD4, SMAD7, LEF1, SNAI2, BIRC3 | More | | | Indomethacin | hsa04510 | Focal adhesion | 4.84E-04 | 11 | P42338, Q15942, P17252, O15335, Q13489, P10415, P08069, Q9NRA1, P49767, Q92529, P63261 | PIK3CB, ZYX, PRKCA, CHAD, BIRC3, BCL2, IGF1R, PDGFC, VEGFC, SHC3, ACTG1 | More | | | Indomethacin | hsa04512 | ECM-receptor interaction | 2.00E-02 | 2 | P07359, P08514 | GP1BA, ITGA2B | More | | | Indomethacin | hsa04514 | Cell adhesion molecules | 7.16E-05 | 4 | P23229, P16109, P30511, O00501 | ITGA6, SELP, HLA-F, CLDN5 | More | | | Indomethacin | hsa04520 | Adherens junction | 2.26E-03 | 5 | Q13485, Q9UJU2, O43623, P08069, P63261 | SMAD4, LEF1, SNAI2, IGF1R, ACTG1 | More | | | Indomethacin | hsa04530 | Tight junction | 3.70E-04 | 7 | P63261, P16989, P56750, O00501, Q92974, Q14247, P24844 | ACTG1, CSDA, CLDN17, CLDN5, ARHGEF2, CTTN, MYL9 | More | | | Indomethacin | hsa04540 | Gap junction | 1.30E-03 | 5 | P17252, Q13509, P68371, Q71U36, Q9NRA1 | PRKCA, TUBB3, TUBB2C, TUBA1A, PDGFC | More | | | Indomethacin | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 1.58E-03 | 3 | P04628, P40189, P08069 | WNT1, IL6ST, IGF1R | More | | | Indomethacin | hsa04610 | Complement and coagulation cascades | 1.01E-06 | 1 | P0C0L4 | C4A | More | | | Indomethacin | hsa04611 | Platelet activation | 1.00E-05 | 8 | P25116, P08514, P42338, Q14344, Q15746, Q8WYR1, P07359, P07948 | F2R, ITGA2B, PIK3CB, GNA13, MYLK, PIK3R5, GP1BA, LYN | More | | | Indomethacin | hsa04612 | Antigen processing and presentation | 2.58E-04 | 7 | P13765, Q14953, P26715, P26717, Q13241, P01732, P01375 | HLA-DOB, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF | More | | | Indomethacin | hsa04613 | Neutrophil extracellular trap formation | 2.84E-10 | 24 | P17252, P16109, O60603, P05164, P08246, Q9UM07, Q6FI13, Q99878, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539 | PRKCA, SELP, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, H2AC14, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| Q15722 | LTB4R | Leukotriene B4 receptor 1 | P17252 | PRKCA | Protein kinase C alpha type | -0.757 | | P08246 | ELA2 | Neutrophil elastase | P17252 | PRKCA | Protein kinase C alpha type | -0.735 | | P16109 | SELP | P-selectin | P16109 | SELP | P-selectin | 1 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | O60603 | TLR2 | Toll-like receptor 2 | -0.717 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O60603 | TLR2 | Toll-like receptor 2 | 0.836 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O60603 | TLR2 | Toll-like receptor 2 | 0.942 | | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | | P22748 | CA4 | Carbonic anhydrase 4 | O60603 | TLR2 | Toll-like receptor 2 | 0.919 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P05164 | MPO | Myeloperoxidase | -0.866 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P05164 | MPO | Myeloperoxidase | 0.858 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P05164 | MPO | Myeloperoxidase | 0.805 | | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | | P22748 | CA4 | Carbonic anhydrase 4 | P05164 | MPO | Myeloperoxidase | 0.826 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P08246 | ELA2 | Neutrophil elastase | -0.76 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P08246 | ELA2 | Neutrophil elastase | 0.817 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P08246 | ELA2 | Neutrophil elastase | 0.846 | | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | | P22748 | CA4 | Carbonic anhydrase 4 | P08246 | ELA2 | Neutrophil elastase | 0.921 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | -0.819 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.813 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.799 | | P08246 | ELA2 | Neutrophil elastase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.889 | | P22748 | CA4 | Carbonic anhydrase 4 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.856 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.833 | | P08246 | ELA2 | Neutrophil elastase | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.907 | | P22748 | CA4 | Carbonic anhydrase 4 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.866 | | P16109 | SELP | P-selectin | Q99878 | H2AC14 | Histone H2A type 1-J | 0.839 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | | P08246 | ELA2 | Neutrophil elastase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.762 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.731 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.836 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.918 | | P08246 | ELA2 | Neutrophil elastase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.945 | | P22748 | CA4 | Carbonic anhydrase 4 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.951 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P20160 | AZU1 | Azurocidin | -0.799 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P20160 | AZU1 | Azurocidin | 0.781 | | P08246 | ELA2 | Neutrophil elastase | P20160 | AZU1 | Azurocidin | 0.842 | | P22748 | CA4 | Carbonic anhydrase 4 | P20160 | AZU1 | Azurocidin | 0.747 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P08311 | CTSG | Cathepsin G | -0.811 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P08311 | CTSG | Cathepsin G | 0.829 | | P08246 | ELA2 | Neutrophil elastase | P08311 | CTSG | Cathepsin G | 0.792 | | P22748 | CA4 | Carbonic anhydrase 4 | P08311 | CTSG | Cathepsin G | 0.717 | | P08246 | ELA2 | Neutrophil elastase | P49913 | CAMP | Cathelicidin antimicrobial peptide | 0.807 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.852 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.737 | | P22748 | CA4 | Carbonic anhydrase 4 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.81 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | -0.772 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.888 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.875 | | P08246 | ELA2 | Neutrophil elastase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.703 | | P22748 | CA4 | Carbonic anhydrase 4 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.826 | | P16109 | SELP | P-selectin | P08514 | ITGA2B | Integrin alpha-IIb | 0.781 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.833 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.888 | | P08246 | ELA2 | Neutrophil elastase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.85 | | P22748 | CA4 | Carbonic anhydrase 4 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.895 | | P16109 | SELP | P-selectin | P07359 | GP1BA | Platelet glycoprotein Ib alpha chain | 0.794 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O43315 | AQP9 | Aquaporin-9 | 0.897 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O43315 | AQP9 | Aquaporin-9 | 0.79 | | P22748 | CA4 | Carbonic anhydrase 4 | O43315 | AQP9 | Aquaporin-9 | 0.771 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.721 | | P22748 | CA4 | Carbonic anhydrase 4 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.767 |
| | Indomethacin | hsa04614 | Renin-angiotensin system | 1.52E-02 | 1 | P50052 | AGTR2 | More | | | Indomethacin | hsa04621 | NOD-like receptor signaling pathway | 3.34E-04 | 14 | Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838 | MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4 | More | | | Indomethacin | hsa04623 | Cytosolic DNA-sensing pathway | 1.31E-03 | 2 | P01568, P25963 | IFNA21, NFKBIA | More | | | Indomethacin | hsa04630 | JAK-STAT signaling pathway | 3.09E-03 | 3 | O75925, P40189, Q06124 | PIAS1, IL6ST, PTPN11 | More | | | Indomethacin | hsa04650 | Natural killer cell mediated cytotoxicity | 1.27E-05 | 10 | P01375, P06239, O60880, P20963, Q13241, P26718, O14931, P26717, Q14953, P26715 | TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1 | More | | | Indomethacin | hsa04657 | IL-17 signaling pathway | 1.79E-05 | 11 | P07900, O00463, Q16539, P49841, P09341, P19875, P14780, Q9UJX4, P80188, P01375, P01584 | HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, ANAPC5, LCN2, TNF, IL1B | More | | | Indomethacin | hsa04658 | Th1 and Th2 cell differentiation | 1.71E-13 | 16 | Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P42226, P23771, Q9UL17, P14784, P13765, Q13761 | PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, STAT6, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q04759 | PRKCQ | Protein kinase C theta type | 0.776 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q04759 | PRKCQ | Protein kinase C theta type | -0.812 | | P06746 | POLB | DNA polymerase beta | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.736 | | P13612 | ITGA4 | Integrin alpha-4 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.729 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.852 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.761 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.74 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.728 | | P13612 | ITGA4 | Integrin alpha-4 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.768 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.775 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.744 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.723 | | P13612 | ITGA4 | Integrin alpha-4 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.85 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.817 | | P06746 | POLB | DNA polymerase beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.787 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.762 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.84 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.708 | | P13612 | ITGA4 | Integrin alpha-4 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.732 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.825 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.767 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.75 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.742 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.736 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P42226 | STAT6 | Signal transducer and activator of transcription 6 | 0.852 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.85 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.753 | | P13612 | ITGA4 | Integrin alpha-4 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.764 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.735 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.738 | | P13612 | ITGA4 | Integrin alpha-4 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.822 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.752 | | P06746 | POLB | DNA polymerase beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.766 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.795 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.795 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.845 | | P06746 | POLB | DNA polymerase beta | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.738 | | P13612 | ITGA4 | Integrin alpha-4 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.78 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | Q13761 | RUNX3 | Runt-related transcription factor 3 | -0.725 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | -0.721 |
| | Indomethacin | hsa04659 | Th17 cell differentiation | 8.49E-11 | 20 | P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P42226, P14784, P13765, P14778, P40189, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963 | NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, STAT6, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q04759 | PRKCQ | Protein kinase C theta type | 0.776 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q04759 | PRKCQ | Protein kinase C theta type | -0.812 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.817 | | P06746 | POLB | DNA polymerase beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.787 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.762 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.84 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.708 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.825 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.767 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.75 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P42226 | STAT6 | Signal transducer and activator of transcription 6 | 0.852 | | P06746 | POLB | DNA polymerase beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.766 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.717 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.795 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.795 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.845 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.936 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.764 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.735 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.738 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.752 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.85 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.753 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | -0.77 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | P06746 | POLB | DNA polymerase beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.834 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 1 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | P06746 | POLB | DNA polymerase beta | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.736 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.852 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.761 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.838 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.744 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.723 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.74 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.728 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.775 |
| | Indomethacin | hsa04660 | T cell receptor signaling pathway | 2.78E-08 | 19 | P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841 | TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P06737 | PYGL | Glycogen phosphorylase, liver form | P01375 | TNF | Tumor necrosis factor | 0.759 | | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.723 | | P08246 | ELA2 | Neutrophil elastase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.896 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q04759 | PRKCQ | Protein kinase C theta type | 0.776 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q04759 | PRKCQ | Protein kinase C theta type | -0.812 | | P08246 | ELA2 | Neutrophil elastase | Q04759 | PRKCQ | Protein kinase C theta type | -0.748 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.751 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | 0.794 | | P08246 | ELA2 | Neutrophil elastase | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | -0.854 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.73 | | P13612 | ITGA4 | Integrin alpha-4 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.834 | | P08246 | ELA2 | Neutrophil elastase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.724 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.746 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.8 | | P13612 | ITGA4 | Integrin alpha-4 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | | P08246 | ELA2 | Neutrophil elastase | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.782 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.762 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P16333 | NCK1 | Cytoplasmic protein NCK1 | -0.781 | | P13612 | ITGA4 | Integrin alpha-4 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.729 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.852 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.761 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.74 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.728 | | P13612 | ITGA4 | Integrin alpha-4 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.768 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.775 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.744 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.723 | | P13612 | ITGA4 | Integrin alpha-4 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.85 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.84 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.708 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.92 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.72 | | P13612 | ITGA4 | Integrin alpha-4 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.7 | | P13612 | ITGA4 | Integrin alpha-4 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.83 | | P13612 | ITGA4 | Integrin alpha-4 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.732 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.825 | | P30304 | CDC25A | M-phase inducer phosphatase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.767 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.817 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.815 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.812 |
| | Indomethacin | hsa04662 | B cell receptor signaling pathway | 1.46E-05 | 6 | P49841, P42338, P60033, P07948, P21854, Q8N149 | GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2 | More | | | Indomethacin | hsa04664 | Fc epsilon RI signaling pathway | 1.47E-07 | 6 | P04141, Q16539, P42338, P07948, P19174, P09917 | CSF2, MAPK14, PIK3CB, LYN, PLCG1, ALOX5 | More | | | Indomethacin | hsa04666 | Fc gamma R-mediated phagocytosis | 1.40E-04 | 8 | P07948, P42338, P19174, P23528, P06396, O14494, P14598, P17252 | LYN, PIK3CB, PLCG1, CFL1, GSN, PLPP1, NCF1, PRKCA | More | | | Indomethacin | hsa04668 | TNF signaling pathway | 4.02E-04 | 12 | P01375, O00463, Q13489, P25963, Q99941, P18848, P19875, P01584, P20749, Q13077, P14780, O95429 | TNF, TRAF5, BIRC3, NFKBIA, CREBL1, ATF4, CXCL2, IL1B, BCL3, TRAF1, MMP9, BAG4 | More | | | Indomethacin | hsa04670 | Leukocyte transendothelial migration | 4.20E-02 | 7 | P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681 | MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK | More | | | Indomethacin | hsa04672 | Intestinal immune network for IgA production | 6.10E-04 | 3 | P29965, P10747, P13765 | CD40LG, CD28, HLA-DOB | More | | | Indomethacin | hsa04710 | Circadian rhythm | 1.67E-02 | 2 | Q16526, Q9Y478 | CRY1, PRKAB1 | More | | | Indomethacin | hsa04713 | Circadian entrainment | 2.18E-02 | 4 | P0DP23, P62873, P63218, P50151 | CALM1, GNB1, GNG5, GNG10 | More | | | Indomethacin | hsa04720 | Long-term potentiation | 2.74E-03 | 4 | P17252, Q16566, P0DP23, O15399 | PRKCA, CAMK4, CALM1, GRIN2D | More | | | Indomethacin | hsa04721 | Synaptic vesicle cycle | 2.82E-03 | 4 | Q13488, Q99437, P43005, P31645 | TCIRG1, ATP6V0B, SLC1A1, SLC6A4 | More | | | Indomethacin | hsa04722 | Neurotrophin signaling pathway | 4.87E-02 | 3 | P42338, P19174, Q92529 | PIK3CB, PLCG1, SHC3 | More | | | Indomethacin | hsa04723 | Retrograde endocannabinoid signaling | 1.71E-03 | 8 | Q14643, P17252, P63218, P50151, P48058, P22694, Q16539, Q16718 | ITPR1, PRKCA, GNG5, GNG10, GRIA4, PRKACB, MAPK14, NDUFA5 | More | | | Indomethacin | hsa04724 | Glutamatergic synapse | 1.67E-05 | 6 | P48058, P43003, P62873, P63218, P50151, P15104 | GRIA4, SLC1A3, GNB1, GNG5, GNG10, GLUL | More | | | Indomethacin | hsa04725 | Cholinergic synapse | 1.73E-02 | 3 | P63218, P50151, P42338 | GNG5, GNG10, PIK3CB | More | | | Indomethacin | hsa04726 | Serotonergic synapse | 3.50E-03 | 4 | P62873, P63218, P50151, P09917 | GNB1, GNG5, GNG10, ALOX5 | More | | | Indomethacin | hsa04727 | GABAergic synapse | 7.25E-05 | 4 | P62873, P63218, P50151, P15104 | GNB1, GNG5, GNG10, GLUL | More | | | Indomethacin | hsa04728 | Dopaminergic synapse | 2.35E-02 | 6 | P63218, P50151, P49841, Q16539, P49407, P48058 | GNG5, GNG10, GSK3B, MAPK14, ARRB1, GRIA4 | More | | | Indomethacin | hsa04730 | Long-term depression | 3.78E-06 | 3 | Q14344, P08069, P07948 | GNA13, IGF1R, LYN | More | | | Indomethacin | hsa04744 | Phototransduction | 2.97E-04 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Indomethacin | hsa04750 | Inflammatory mediator regulation of TRP channels | 3.74E-02 | 3 | P01584, P51828, Q13557 | IL1B, ADCY7, CAMK2D | More | | | Indomethacin | hsa04810 | Regulation of actin cytoskeleton | 2.68E-02 | 2 | P23229, Q14344 | ITGA6, GNA13 | More | | | Indomethacin | hsa04910 | Insulin signaling pathway | 4.11E-02 | 3 | Q92529, Q13370, P42338 | SHC3, PDE3B, PIK3CB | More | | | Indomethacin | hsa04911 | Insulin secretion | 1.48E-02 | 3 | P51828, Q99941, Q13557 | ADCY7, CREBL1, CAMK2D | More | | | Indomethacin | hsa04912 | GnRH signaling pathway | 3.14E-03 | 5 | P17252, Q16539, Q9Y6R4, Q14643, P22694 | PRKCA, MAPK14, MAP3K4, ITPR1, PRKACB | More | | | Indomethacin | hsa04913 | Ovarian steroidogenesis | 7.72E-03 | 3 | P42330, P22694, P08069 | AKR1C3, PRKACB, IGF1R | More | | | Indomethacin | hsa04914 | Progesterone-mediated oocyte maturation | 8.48E-04 | 4 | P08069, P42338, Q13370, P08238 | IGF1R, PIK3CB, PDE3B, HSP90AB1 | More | | | Indomethacin | hsa04915 | Estrogen signaling pathway | 7.27E-04 | 7 | Q99941, P51828, P42338, Q92529, P07900, P08238, P11142 | CREBL1, ADCY7, PIK3CB, SHC3, HSP90AA1, HSP90AB1, HSPA8 | More | | | Indomethacin | hsa04916 | Melanogenesis | 4.47E-03 | 4 | P0DP23, Q9UJU2, P17252, P04628 | CALM1, LEF1, PRKCA, WNT1 | More | | | Indomethacin | hsa04918 | Thyroid hormone synthesis | 3.16E-02 | 2 | P17252, P27824 | PRKCA, CANX | More | | | Indomethacin | hsa04920 | Adipocytokine signaling pathway | 3.17E-04 | 7 | P25963, Q06124, P33121, Q9Y478, Q04759, Q96RR4, P01375 | NFKBIA, PTPN11, ACSL1, PRKAB1, PRKCQ, CAMKK2, TNF | More | | | Indomethacin | hsa04921 | Oxytocin signaling pathway | 6.41E-03 | 6 | Q15746, P0DP23, P17252, Q16566, P63261, Q8WYR1 | MYLK, CALM1, PRKCA, CAMK4, ACTG1, PIK3R5 | More | | | Indomethacin | hsa04922 | Glucagon signaling pathway | 4.23E-02 | 4 | P22694, P06737, Q12778, Q14643 | PRKACB, PYGL, FOXO1, ITPR1 | More | | | Indomethacin | hsa04923 | Regulation of lipolysis in adipocytes | 3.64E-02 | 2 | Q13370, P42338 | PDE3B, PIK3CB | More | | | Indomethacin | hsa04924 | Renin secretion | 7.49E-05 | 5 | P22694, P07550, Q14643, Q13370, P0DP23 | PRKACB, ADRB2, ITPR1, PDE3B, CALM1 | More | | | Indomethacin | hsa04925 | Aldosterone synthesis and secretion | 1.07E-04 | 7 | Q99941, P51828, P0DP23, P17252, Q16566, Q13557, P23634 | CREBL1, ADCY7, CALM1, PRKCA, CAMK4, CAMK2D, ATP2B4 | More | | | Indomethacin | hsa04926 | Relaxin signaling pathway | 1.18E-04 | 9 | P42338, P63218, P50151, P18848, P22694, P49767, P14780, Q92529, P30679 | PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, SHC3, GNA15 | More | | | Indomethacin | hsa04927 | Cortisol synthesis and secretion | 2.54E-02 | 2 | P18848, P22694 | ATF4, PRKACB | More | | | Indomethacin | hsa04928 | Parathyroid hormone synthesis, secretion and action | 4.10E-03 | 5 | Q14643, P22694, P23771, P17252, P10415 | ITPR1, PRKACB, GATA3, PRKCA, BCL2 | More | | | Indomethacin | hsa04931 | Insulin resistance | 1.48E-02 | 2 | Q06124, Q9Y478 | PTPN11, PRKAB1 | More | | | Indomethacin | hsa04932 | Non-alcoholic fatty liver disease | 9.70E-03 | 4 | P18848, P01584, P13073, O15239 | ATF4, IL1B, COX4I1, NDUFA1 | More | | | Indomethacin | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 3.90E-04 | 7 | P84022, Q13485, P10415, P42338, P49767, P17252, P19174 | SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PRKCA, PLCG1 | More | | | Indomethacin | hsa04934 | Cushing syndrome | 3.48E-03 | 4 | Q99941, P51828, O15169, Q13557 | CREBL1, ADCY7, AXIN1, CAMK2D | More | | | Indomethacin | hsa04935 | Growth hormone synthesis, secretion and action | 2.78E-02 | 3 | P19174, P42338, Q92529 | PLCG1, PIK3CB, SHC3 | More | | | Indomethacin | hsa04964 | Proximal tubule bicarbonate reclamation | 2.17E-03 | 1 | P00918 | CA2 | More | | | Indomethacin | hsa04966 | Collecting duct acid secretion | 2.17E-03 | 1 | P00918 | CA2 | More | | | Indomethacin | hsa04970 | Salivary secretion | 2.70E-04 | 7 | P07550, P22694, Q14643, P23634, P17252, P0DP23, P49913 | ADRB2, PRKACB, ITPR1, ATP2B4, PRKCA, CALM1, CAMP | More | | | Indomethacin | hsa04971 | Gastric acid secretion | 1.87E-03 | 6 | P51828, P17252, P15311, P63261, P0DP23, Q13557 | ADCY7, PRKCA, VIL2, ACTG1, CALM1, CAMK2D | More | | | Indomethacin | hsa04973 | Carbohydrate digestion and absorption | 1.57E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | | Indomethacin | hsa04978 | Mineral absorption | 3.94E-02 | 2 | P23634, Q9BXS9 | ATP2B4, SLC26A6 | More | | | Indomethacin | hsa05010 | Alzheimer disease | 2.07E-02 | 7 | Q92542, P05496, P12074, O75460, P01584, O15169, P45880 | NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2 | More | | | Indomethacin | hsa05012 | Parkinson disease | 1.60E-04 | 12 | O15239, P13073, P05141, P21796, P60604, P18848, P19174, P0DP23, Q13557, Q71U36, Q13509, P68371 | NDUFA1, COX4I1, SLC25A5, VDAC1, UBE2G2, ATF4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3, TUBB2C | More | | | Indomethacin | hsa05014 | Amyotrophic lateral sclerosis | 4.31E-02 | 7 | O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0 | GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2B | More | | | Indomethacin | hsa05016 | Huntington disease | 3.21E-02 | 5 | O15239, P13073, P30876, P62487, P05141 | NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5 | More | | | Indomethacin | hsa05020 | Prion disease | 1.80E-05 | 15 | P13591, P01584, P46531, P11142, O15239, P05496, P13073, P12074, P18848, P05141, P21796, P45880, Q71U36, Q13509, Q99941 | NCAM1, IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX4I1, COX6A1, ATF4, SLC25A5, VDAC1, VDAC2, TUBA1A, TUBB3, CREBL1 | More | | | Indomethacin | hsa05022 | Pathways of neurodegeneration - multiple diseases | 4.29E-03 | 11 | Q71U36, Q13509, O15239, P13073, P21796, P18848, P05141, P04628, P01584, Q13557, P60604 | TUBA1A, TUBB3, NDUFA1, COX4I1, VDAC1, ATF4, SLC25A5, WNT1, IL1B, CAMK2D, UBE2G2 | More | | | Indomethacin | hsa05031 | Amphetamine addiction | 1.61E-03 | 7 | O15399, P0DP23, Q16566, P22694, P18848, P17252, Q13547 | GRIN2D, CALM1, CAMK4, PRKACB, ATF4, PRKCA, HDAC1 | More | | | Indomethacin | hsa05032 | Morphine addiction | 1.32E-03 | 4 | P62873, P63218, P50151, Q13370 | GNB1, GNG5, GNG10, PDE3B | More | | | Indomethacin | hsa05034 | Alcoholism | 2.89E-03 | 4 | Q93077, P62807, O60814, P68431 | HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Indomethacin | hsa05100 | Bacterial invasion of epithelial cells | 3.64E-02 | 2 | P42338, Q92529 | PIK3CB, SHC3 | More | | | Indomethacin | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 7.84E-05 | 9 | Q16539, P25963, Q13488, Q99437, P10145, P19174, P25024, P25025, P07948 | MAPK14, NFKBIA, TCIRG1, ATP6V0B, IL8, PLCG1, CXCR1, CXCR2, LYN | More | | | Indomethacin | hsa05130 | Pathogenic Escherichia coli infection | 3.19E-02 | 6 | Q71U36, P16333, Q13509, P68371, Q14344, P25963 | TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA | More | | | Indomethacin | hsa05131 | Shigellosis | 3.34E-02 | 11 | P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32 | TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF | More | | | Indomethacin | hsa05132 | Salmonella infection | 5.59E-05 | 17 | P51617, P25963, P01375, P08238, Q9UJU2, P63261, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754 | IRAK1, NFKBIA, TNF, HSP90AB1, LEF1, ACTG1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41 | More | | | Indomethacin | hsa05133 | Pertussis | 2.28E-05 | 5 | P0DP23, P10145, P23528, P09871, P0C0L4 | CALM1, IL8, CFL1, C1S, C4A | More | | | Indomethacin | hsa05134 | Legionellosis | 2.12E-03 | 5 | P01584, P25963, P11215, P68104, P11142 | IL1B, NFKBIA, ITGAM, EEF1A1, HSPA8 | More | | | Indomethacin | hsa05135 | Yersinia infection | 9.51E-03 | 6 | P13612, P06239, Q16539, P42338, P49841, P01730 | ITGA4, LCK, MAPK14, PIK3CB, GSK3B, CD4 | More | | | Indomethacin | hsa05140 | Leishmaniasis | 8.06E-05 | 10 | P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P51617, Q15080 | NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, IRAK1, NCF4 | More | | | Indomethacin | hsa05143 | African trypanosomiasis | 1.31E-02 | 2 | P69905, P68871 | HBA2, HBB | More | | | Indomethacin | hsa05144 | Malaria | 1.44E-03 | 5 | P69905, P68871, P01375, P35443, P26718 | HBA2, HBB, TNF, THBS4, KLRK1 | More | | | Indomethacin | hsa05145 | Toxoplasmosis | 3.07E-02 | 7 | P51617, P25963, P01375, P10415, Q13489, P13765, O60603 | IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2 | More | | | Indomethacin | hsa05146 | Amoebiasis | 2.41E-02 | 4 | P19875, P01375, P30679, P22694 | CXCL2, TNF, GNA15, PRKACB | More | | | Indomethacin | hsa05150 | Staphylococcus aureus infection | 6.28E-04 | 10 | P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, Q14532, P16109, P12838 | C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, KRT32, SELP, DEFA4 | More | | | Indomethacin | hsa05152 | Tuberculosis | 2.89E-05 | 13 | Q13488, P0DP23, O75015, P48382, O60603, P01375, P10415, P13765, P01568, P49913, Q9UDY8, Q16539, P51617 | TCIRG1, CALM1, FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, IFNA21, CAMP, MALT1, MAPK14, IRAK1 | More | | | Indomethacin | hsa05161 | Hepatitis B | 2.33E-02 | 8 | P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765 | PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4 | More | | | Indomethacin | hsa05162 | Measles | 4.15E-03 | 6 | P14784, P07766, P42338, P11142, P01584, Q9NP90 | IL2RB, CD3E, PIK3CB, HSPA8, IL1B, RAB9B | More | | | Indomethacin | hsa05163 | Human cytomegalovirus infection | 3.34E-07 | 16 | P42338, P30511, P25963, P62873, P63218, P50151, P0DP23, Q14344, P49841, P14778, Q13651, P25025, Q16539, O00463, P30101, P01568 | PIK3CB, HLA-F, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, TRAF5, PDIA3, IFNA21 | More | | | Indomethacin | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 3.95E-06 | 11 | P01568, P42224, P25963, P42338, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23 | IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1 | More | | | Indomethacin | hsa05168 | Herpes simplex virus 1 infection | 1.66E-06 | 19 | Q9UKJ0, P25963, P01568, Q05823, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9UDV6, P10415 | PILRB, NFKBIA, IFNA21, RNASEL, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212, BCL2 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P46091 | GPR1 | Chemerin-like receptor 2 | Q9UKJ0 | PILRB | Paired immunoglobulin-like type 2 receptor beta | -0.781 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.768 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P01568 | IFNA21 | Interferon alpha-21 | -0.764 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P01568 | IFNA21 | Interferon alpha-21 | -0.733 | | P46091 | GPR1 | Chemerin-like receptor 2 | P01568 | IFNA21 | Interferon alpha-21 | 0.724 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q05823 | RNASEL | 2-5A-dependent ribonuclease | 0.752 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q9GZY0 | NXF2; NXF2B | Nuclear RNA export factor 2 | 0.707 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.787 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.732 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.827 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.783 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.746 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.819 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.943 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.721 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.759 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.83 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13398 | ZNF211 | Zinc finger protein 211 | 0.729 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13398 | ZNF211 | Zinc finger protein 211 | 0.763 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q13398 | ZNF211 | Zinc finger protein 211 | 0.849 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q13398 | ZNF211 | Zinc finger protein 211 | -0.71 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q9HCX3 | ZNF304 | Zinc finger protein 304 | -0.746 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q03923 | ZNF85 | Zinc finger protein 85 | -0.73 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q03923 | ZNF85 | Zinc finger protein 85 | 0.705 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P52738 | ZNF140 | Zinc finger protein 140 | -0.724 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | O75820 | ZNF189 | Zinc finger protein 189 | -0.722 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O75820 | ZNF189 | Zinc finger protein 189 | -0.766 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q9UDV6 | ZNF212 | Zinc finger protein 212 | 0.824 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q9UDV6 | ZNF212 | Zinc finger protein 212 | 0.776 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q9UDV6 | ZNF212 | Zinc finger protein 212 | -0.75 | | P46091 | GPR1 | Chemerin-like receptor 2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.808 |
| | Indomethacin | hsa05169 | Epstein-Barr virus infection | 5.28E-04 | 17 | P13765, Q13547, O00463, P16070, P10415, Q16539, P42338, P07948, P30101, Q13761, P24522, Q8WV28, P01375, O60603, P07766, P09693, P20963 | HLA-DOB, HDAC1, TRAF5, CD44, BCL2, MAPK14, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, BLNK, TNF, TLR2, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P06737 | PYGL | Glycogen phosphorylase, liver form | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.845 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.773 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.924 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.719 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P16070 | CD44 | CD44 antigen | 0.803 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.766 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.863 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.817 | | P06746 | POLB | DNA polymerase beta | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.74 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.751 | | P06746 | POLB | DNA polymerase beta | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.804 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.795 | | P06746 | POLB | DNA polymerase beta | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.751 | | P06746 | POLB | DNA polymerase beta | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.738 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | Q13761 | RUNX3 | Runt-related transcription factor 3 | -0.725 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.822 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.724 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q8WV28 | BLNK | B-cell linker protein | -0.706 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P01375 | TNF | Tumor necrosis factor | 0.759 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O60603 | TLR2 | Toll-like receptor 2 | 0.836 | | P06746 | POLB | DNA polymerase beta | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.736 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.852 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.723 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.728 | | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.775 |
| | Indomethacin | hsa05170 | Human immunodeficiency virus 1 infection | 4.57E-08 | 23 | P42338, P62873, P63218, P50151, P0DP23, P01375, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P23528, P07766, P10415, Q13619, Q93034, Q9Y6Q5 | PIK3CB, GNB1, GNG5, GNG10, CALM1, TNF, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CFL1, CD3E, BCL2, CUL4A, CUL5, AP1M2 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P06746 | POLB | DNA polymerase beta | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.74 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.777 | | P06746 | POLB | DNA polymerase beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.736 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | P06746 | POLB | DNA polymerase beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.804 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P0DP23 | CALM1 | Calmodulin-1 | 0.775 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P0DP23 | CALM1 | Calmodulin-1 | -0.772 | | P08246 | ELA2 | Neutrophil elastase | P01375 | TNF | Tumor necrosis factor | 0.751 | | P08246 | ELA2 | Neutrophil elastase | P17252 | PRKCA | Protein kinase C alpha type | -0.735 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P17252 | PRKCA | Protein kinase C alpha type | 0.844 | | P08246 | ELA2 | Neutrophil elastase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.814 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.773 | | P06746 | POLB | DNA polymerase beta | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.751 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.83 | | P08246 | ELA2 | Neutrophil elastase | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.816 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.858 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P01568 | IFNA21 | Interferon alpha-21 | -0.733 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P01568 | IFNA21 | Interferon alpha-21 | 0.721 | | P08246 | ELA2 | Neutrophil elastase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.734 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 0.807 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P08246 | ELA2 | Neutrophil elastase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.701 | | P08246 | ELA2 | Neutrophil elastase | O60603 | TLR2 | Toll-like receptor 2 | 0.853 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | O60603 | TLR2 | Toll-like receptor 2 | -0.884 | | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | | P08246 | ELA2 | Neutrophil elastase | O95067 | CCNB2 | G2/mitotic-specific cyclin-B2 | 0.711 | | P06746 | POLB | DNA polymerase beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.787 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P23528 | CFL1 | Cofilin-1 | 0.741 | | P06746 | POLB | DNA polymerase beta | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.736 | | P08246 | ELA2 | Neutrophil elastase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.942 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 1 | | P08246 | ELA2 | Neutrophil elastase | Q13619 | CUL4A | Cullin-4A | -0.707 | | P08246 | ELA2 | Neutrophil elastase | Q93034 | CUL5 | Cullin-5 | -0.744 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q93034 | CUL5 | Cullin-5 | 0.704 | | P08246 | ELA2 | Neutrophil elastase | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | 0.811 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | -0.901 |
| | Indomethacin | hsa05171 | Coronavirus disease - COVID-19 | 9.72E-03 | 7 | P01584, P62753, P25398, P36578, P32969, P18077, P62829 | IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23 | More | | | Indomethacin | hsa05200 | Pathways in cancer | 1.02E-07 | 31 | Q13751, P42338, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, Q13547, P14923, P30281, P10415, Q13489, P49767, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P40189 | LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | | P06746 | POLB | DNA polymerase beta | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.74 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P06746 | POLB | DNA polymerase beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.834 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 1 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P06746 | POLB | DNA polymerase beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.787 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.736 | | P46091 | GPR1 | Chemerin-like receptor 2 | P17252 | PRKCA | Protein kinase C alpha type | 0.741 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.87 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.816 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.811 | | P46091 | GPR1 | Chemerin-like receptor 2 | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.838 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | -0.77 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.809 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P20585 | MSH3 | DNA mismatch repair protein Msh3 | 0.825 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.754 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14923 | JUP | Junction plakoglobin | -0.735 | | P46091 | GPR1 | Chemerin-like receptor 2 | P14923 | JUP | Junction plakoglobin | 0.883 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | | P46091 | GPR1 | Chemerin-like receptor 2 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.808 | | P46091 | GPR1 | Chemerin-like receptor 2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.759 | | P06746 | POLB | DNA polymerase beta | P49767 | VEGFC | Vascular endothelial growth factor C | -0.78 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | | P46091 | GPR1 | Chemerin-like receptor 2 | P49767 | VEGFC | Vascular endothelial growth factor C | 0.718 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | | P46091 | GPR1 | Chemerin-like receptor 2 | P25116 | F2R | Proteinase-activated receptor 1 | 0.76 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.82 | | P06746 | POLB | DNA polymerase beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.736 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.703 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P06746 | POLB | DNA polymerase beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.804 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.704 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P06746 | POLB | DNA polymerase beta | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | -0.75 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | -0.756 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | P46091 | GPR1 | Chemerin-like receptor 2 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | 0.738 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.748 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.742 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.731 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P0DP23 | CALM1 | Calmodulin-1 | 0.755 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P0DP23 | CALM1 | Calmodulin-1 | 0.775 | | P46091 | GPR1 | Chemerin-like receptor 2 | P0DP23 | CALM1 | Calmodulin-1 | -0.846 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P01568 | IFNA21 | Interferon alpha-21 | -0.733 | | P46091 | GPR1 | Chemerin-like receptor 2 | P01568 | IFNA21 | Interferon alpha-21 | 0.724 | | P06746 | POLB | DNA polymerase beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.766 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.717 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 |
| | Indomethacin | hsa05202 | Transcriptional misregulation in cancer | 4.11E-13 | 20 | Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q16548, Q13489, Q13077, Q15652, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P24522 | FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, BIRC3, TRAF1, JMJD1C, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, GADD45A | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q12778 | FOXO1 | Forkhead box protein O1 | 0.795 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q12778 | FOXO1 | Forkhead box protein O1 | -0.769 | | P08246 | ELA2 | Neutrophil elastase | Q12778 | FOXO1 | Forkhead box protein O1 | -0.75 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q12778 | FOXO1 | Forkhead box protein O1 | 0.794 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q15532 | SS18 | Protein SSXT | -0.772 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q15532 | SS18 | Protein SSXT | -0.803 | | P08246 | ELA2 | Neutrophil elastase | Q15532 | SS18 | Protein SSXT | -0.806 | | P22748 | CA4 | Carbonic anhydrase 4 | Q15532 | SS18 | Protein SSXT | -0.862 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q15532 | SS18 | Protein SSXT | 0.877 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q13315 | ATM | Serine-protein kinase ATM | 0.723 | | P08246 | ELA2 | Neutrophil elastase | Q13315 | ATM | Serine-protein kinase ATM | -0.742 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P41732 | TSPAN7 | Tetraspanin-7 | 0.775 | | P22748 | CA4 | Carbonic anhydrase 4 | P41732 | TSPAN7 | Tetraspanin-7 | 0.706 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.746 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.917 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.861 | | P08246 | ELA2 | Neutrophil elastase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.859 | | P22748 | CA4 | Carbonic anhydrase 4 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.925 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.765 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.881 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.734 | | P22748 | CA4 | Carbonic anhydrase 4 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.708 | | P08246 | ELA2 | Neutrophil elastase | P14923 | JUP | Junction plakoglobin | -0.811 | | P22748 | CA4 | Carbonic anhydrase 4 | P14923 | JUP | Junction plakoglobin | -0.772 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P14923 | JUP | Junction plakoglobin | 0.861 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.701 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.967 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.837 | | P08246 | ELA2 | Neutrophil elastase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.766 | | P22748 | CA4 | Carbonic anhydrase 4 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.833 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.746 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.797 | | P08246 | ELA2 | Neutrophil elastase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.716 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.848 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.783 | | P08246 | ELA2 | Neutrophil elastase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.725 | | P22748 | CA4 | Carbonic anhydrase 4 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.718 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.816 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q15652 | JMJD1C | Probable JmjC domain-containing histone demethylation protein 2C | 0.754 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | O15550 | UTX | Lysine-specific demethylase 6A | -0.778 | | P06737 | PYGL | Glycogen phosphorylase, liver form | O15550 | UTX | Lysine-specific demethylase 6A | 0.724 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O15550 | UTX | Lysine-specific demethylase 6A | 0.789 | | P22748 | CA4 | Carbonic anhydrase 4 | O15550 | UTX | Lysine-specific demethylase 6A | 0.714 | | P08069 | IGF1R | Insulin-like growth factor 1 receptor | P08069 | IGF1R | Insulin-like growth factor 1 receptor | 1 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.73 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.779 | | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | | P22748 | CA4 | Carbonic anhydrase 4 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.834 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.78 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.73 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.779 | | P08246 | ELA2 | Neutrophil elastase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.824 | | P22748 | CA4 | Carbonic anhydrase 4 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.834 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.78 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P05164 | MPO | Myeloperoxidase | -0.866 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P05164 | MPO | Myeloperoxidase | 0.858 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P05164 | MPO | Myeloperoxidase | 0.805 | | P08246 | ELA2 | Neutrophil elastase | P05164 | MPO | Myeloperoxidase | 0.903 | | P22748 | CA4 | Carbonic anhydrase 4 | P05164 | MPO | Myeloperoxidase | 0.826 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P05164 | MPO | Myeloperoxidase | -0.81 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P12838 | DEFA4 | Neutrophil defensin 4 | 0.7 | | P08246 | ELA2 | Neutrophil elastase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.709 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P08246 | ELA2 | Neutrophil elastase | -0.76 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P08246 | ELA2 | Neutrophil elastase | 0.817 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P08246 | ELA2 | Neutrophil elastase | 0.846 | | P08246 | ELA2 | Neutrophil elastase | P08246 | ELA2 | Neutrophil elastase | 1 | | P22748 | CA4 | Carbonic anhydrase 4 | P08246 | ELA2 | Neutrophil elastase | 0.921 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | P08246 | ELA2 | Neutrophil elastase | -0.942 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.879 | | P06737 | PYGL | Glycogen phosphorylase, liver form | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.742 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.808 | | P08246 | ELA2 | Neutrophil elastase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.75 | | P10415 | BCL2 | Apoptosis regulator Bcl-2 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.766 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.847 | | P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.734 | | P06737 | PYGL | Glycogen phosphorylase, liver form | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.822 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.764 | | P08246 | ELA2 | Neutrophil elastase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.7 | | P22748 | CA4 | Carbonic anhydrase 4 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.769 |
| | Indomethacin | hsa05203 | Viral carcinogenesis | 6.22E-03 | 5 | Q12933, P42229, Q15283, P62807, O60814 | TRAF2, STAT5A, RASA2, HIST1H2BC, H2BC12 | More | | | Indomethacin | hsa05204 | Chemical carcinogenesis | 1.77E-04 | 4 | Q16772, P09211, P78417, P11712 | GSTA3, GSTP1, GSTO1, CYP2C9 | More | | | Indomethacin | hsa05205 | Proteoglycans in cancer | 8.61E-05 | 15 | Q13009, Q12955, Q14643, O75369, Q14247, P14780, P17252, O60603, P01375, P08069, P23588, P04628, Q13635, P22694, P08962 | TIAM1, ANK3, ITPR1, FLNB, CTTN, MMP9, PRKCA, TLR2, TNF, IGF1R, EIF4B, WNT1, PTCH1, PRKACB, CD63 | More | | | Indomethacin | hsa05206 | MicroRNAs in cancer | 2.97E-03 | 6 | P15311, P21860, P61978, P46531, P63279, P22105 | VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB | More | | | Indomethacin | hsa05212 | Pancreatic cancer | 6.92E-05 | 6 | P42338, P42224, P37173, P84022, Q13485, O75293 | PIK3CB, STAT1, TGFBR2, SMAD3, SMAD4, GADD45B | More | | | Indomethacin | hsa05214 | Glioma | 1.00E-06 | 8 | P08069, P0DP23, Q16566, P17252, Q92529, P42338, P19174, O75293 | IGF1R, CALM1, CAMK4, PRKCA, SHC3, PIK3CB, PLCG1, GADD45B | More | | | Indomethacin | hsa05215 | Prostate cancer | 5.38E-03 | 4 | P08069, Q9NRA1, P08238, P42338 | IGF1R, PDGFC, HSP90AB1, PIK3CB | More | | | Indomethacin | hsa05217 | Basal cell carcinoma | 1.43E-02 | 4 | Q13635, P49841, Q9UJU2, P24522 | PTCH1, GSK3B, LEF1, GADD45A | More | | | Indomethacin | hsa05218 | Melanoma | 2.85E-03 | 3 | P08069, Q9NRA1, P42338 | IGF1R, PDGFC, PIK3CB | More | | | Indomethacin | hsa05220 | Chronic myeloid leukemia | 2.16E-02 | 5 | Q13547, Q13485, P84022, P42338, O75293 | HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B | More | | | Indomethacin | hsa05222 | Small cell lung cancer | 2.79E-02 | 6 | Q13489, P10415, P25963, Q13077, O00463, P24522 | BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A | More | | | Indomethacin | hsa05223 | Non-small cell lung cancer | 4.24E-02 | 3 | P19174, Q9HC35, O75293 | PLCG1, EML4, GADD45B | More | | | Indomethacin | hsa05224 | Breast cancer | 1.49E-02 | 1 | P08069 | IGF1R | More | | | Indomethacin | hsa05225 | Hepatocellular carcinoma | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Indomethacin | hsa05226 | Gastric cancer | 2.94E-02 | 2 | P04628, P10826 | WNT1, RARB | More | | | Indomethacin | hsa05231 | Choline metabolism in cancer | 2.05E-04 | 6 | P42338, Q9NRA1, Q9Y259, P19174, P23743, P49619 | PIK3CB, PDGFC, CHKB, PLCG1, DGKA, DGKG | More | | | Indomethacin | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 7.84E-06 | 13 | P42338, P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730 | PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4 | More | | | Indomethacin | hsa05310 | Asthma | 1.70E-03 | 4 | P13765, P29965, P12724, P01375 | HLA-DOB, CD40LG, RNASE3, TNF | More | | | Indomethacin | hsa05320 | Autoimmune thyroid disease | 7.98E-04 | 4 | P13765, P29965, P01568, P10747 | HLA-DOB, CD40LG, IFNA21, CD28 | More | | | Indomethacin | hsa05321 | Inflammatory bowel disease | 1.35E-09 | 7 | O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771 | TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3 | More | | | Indomethacin | hsa05322 | Systemic lupus erythematosus | 2.09E-04 | 12 | P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455 | ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB | More | | | Indomethacin | hsa05323 | Rheumatoid arthritis | 1.60E-02 | 4 | P13765, P10747, P09341, O60603 | HLA-DOB, CD28, CXCL1, TLR2 | More | | | Indomethacin | hsa05330 | Allograft rejection | 3.16E-02 | 2 | P13765, P29965 | HLA-DOB, CD40LG | More | | | Indomethacin | hsa05332 | Graft-versus-host disease | 1.35E-07 | 5 | P13765, P10747, P01375, P26715, Q13241 | HLA-DOB, CD28, TNF, KLRC1, KLRD1 | More | | | Indomethacin | hsa05340 | Primary immunodeficiency | 4.24E-02 | 3 | P01730, P07766, P06239 | CD4, CD3E, LCK | More | | | Indomethacin | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 3.28E-04 | 4 | P54284, P14923, P08514, Q9UJU2 | CACNB3, JUP, ITGA2B, LEF1 | More | | | Indomethacin | hsa05414 | Dilated cardiomyopathy | 4.55E-02 | 2 | P54284, P26678 | CACNB3, PLN | More | | | Indomethacin | hsa05415 | Diabetic cardiomyopathy | 1.49E-03 | 10 | P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q13557, P04406 | PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, CAMK2D, GAPDH | More | | | Indomethacin | hsa05416 | Viral myocarditis | 4.29E-02 | 2 | P13765, P29965 | HLA-DOB, CD40LG | More | | | Indomethacin | hsa05418 | Fluid shear stress and atherosclerosis | 2.33E-03 | 8 | P42338, P14598, P78417, P63261, P10415, P0DP23, P08238, Q92974 | PIK3CB, NCF1, GSTO1, ACTG1, BCL2, CALM1, HSP90AB1, ARHGEF2 | More | |
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