PharmaCoNets of Indinavir (SPCN: 56.92 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Indinavirhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Indinavirhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Indinavirhsa00220Arginine biosynthesis3.83E-022P05089, P49448ARG1, GLUD2More
Indinavirhsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Indinavirhsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Indinavirhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Indinavirhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Indinavirhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Indinavirhsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Indinavirhsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Indinavirhsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Indinavirhsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Indinavirhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Indinavirhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Indinavirhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Indinavirhsa01522Endocrine resistance1.69E-023Q9UM47, P10415, Q13323NOTCH3, BCL2, BIKMore
Indinavirhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Indinavirhsa03040Spliceosome1.46E-024P17844, P51991, P61978, P11142DDX5, HNRPA3, HNRPK, HSPA8More
Indinavirhsa03430Mismatch repair4.38E-021P20585MSH3More
Indinavirhsa04015Rap1 signaling pathway9.14E-032P06213, O00522INSR, KRIT1More
Indinavirhsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Indinavirhsa04061Viral protein interaction with cytokine and cytokine receptor1.32E-026P09341, P25024, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RBMore
Indinavirhsa04062Chemokine signaling pathway6.73E-039P25024, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881CXCR1, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITKMore
Indinavirhsa04064NF-kappa B signaling pathway7.62E-0412P10415, P51617, O00463, P14778, Q04759, Q9UDY8, Q13077, P07948, P06239, P24522, P09341, Q06643BCL2, IRAK1, TRAF5, IL1R1, PRKCQ, MALT1, TRAF1, LYN, LCK, GADD45A, CXCL1, LTBMore
Indinavirhsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Indinavirhsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Indinavirhsa04151PI3K-Akt signaling pathway3.91E-037P62753, P27348, P07900, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGKMore
Indinavirhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Indinavirhsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Indinavirhsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Indinavirhsa04261Adrenergic signaling in cardiomyocytes1.46E-024P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Indinavirhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Indinavirhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Indinavirhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Indinavirhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Indinavirhsa04612Antigen processing and presentation1.75E-026P13765, P01730, P26715, P26717, Q13241, P01732HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8AMore
Indinavirhsa04613Neutrophil extracellular trap formation1.02E-048P11215, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431ITGAM, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Indinavirhsa04640Hematopoietic cell lineage1.60E-0410P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P09564, P13765ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOBMore
Indinavirhsa04650Natural killer cell mediated cytotoxicity3.08E-038P06239, O60880, P20963, Q13241, P26718, O14931, P26717, P26715LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Indinavirhsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Indinavirhsa04658Th1 and Th2 cell differentiation2.44E-0711Q04759, P07766, P20963, P09693, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Indinavirhsa04659Th17 cell differentiation4.63E-0611Q04759, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Indinavirhsa04660T cell receptor signaling pathway8.91E-049Q04759, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239PRKCQ, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
Indinavirhsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Indinavirhsa04722Neurotrophin signaling pathway3.76E-023P51617, P10415, P0DP23IRAK1, BCL2, CALM1More
Indinavirhsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Indinavirhsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Indinavirhsa04740Olfactory transduction2.07E-022P62873, P0DP23GNB1, CALM1More
Indinavirhsa04744Phototransduction2.27E-032P62873, P0DP23GNB1, CALM1More
Indinavirhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Indinavirhsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Indinavirhsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Indinavirhsa04913Ovarian steroidogenesis2.52E-021P06213INSRMore
Indinavirhsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Indinavirhsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Indinavirhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Indinavirhsa04923Regulation of lipolysis in adipocytes3.76E-021P06213INSRMore
Indinavirhsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Indinavirhsa04926Relaxin signaling pathway3.34E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Indinavirhsa04927Cortisol synthesis and secretion4.16E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Indinavirhsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Indinavirhsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Indinavirhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Indinavirhsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Indinavirhsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Indinavirhsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Indinavirhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Indinavirhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Indinavirhsa04975Fat digestion and absorption4.83E-021O14494PLPP1More
Indinavirhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Indinavirhsa05022Pathways of neurodegeneration - multiple diseases2.95E-022Q06055, O15020ATP5G2, SPTBN2More
Indinavirhsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Indinavirhsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Indinavirhsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Indinavirhsa05132Salmonella infection3.04E-036P51617, Q9UJU2, P10415, O75369, Q9BQS8, Q13509IRAK1, LEF1, BCL2, FLNB, FYCO1, TUBB3More
Indinavirhsa05133Pertussis4.20E-021P0C0L4C4AMore
Indinavirhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Indinavirhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Indinavirhsa05146Amoebiasis9.73E-036P09341, P14778, P27930, P05089, P12814, P08311CXCL1, IL1R1, IL1R2, ARG1, ACTN1, CTSGMore
Indinavirhsa05152Tuberculosis2.90E-035P0DP23, P48382, P10415, Q9UDY8, P51617CALM1, RFX5, BCL2, MALT1, IRAK1More
Indinavirhsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Indinavirhsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Indinavirhsa05170Human immunodeficiency virus 1 infection1.99E-025P62873, P0DP23, P51617, P10415, Q9Y6Q5GNB1, CALM1, IRAK1, BCL2, AP1M2More
Indinavirhsa05200Pathways in cancer4.99E-027Q9UJU2, P14923, P10415, Q13077, P62873, Q9UM47, P0DP23LEF1, JUP, BCL2, TRAF1, GNB1, NOTCH3, CALM1More
Indinavirhsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Indinavirhsa05203Viral carcinogenesis9.17E-0510Q99941, P18848, P27348, Q13547, Q15283, P61978, P58876, P62807, Q16778, O60814CREBL1, ATF4, YWHAQ, HDAC1, RASA2, HNRPK, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Indinavirhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Indinavirhsa05205Proteoglycans in cancer4.10E-024Q13009, Q12955, O75369, P08962TIAM1, ANK3, FLNB, CD63More
Indinavirhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer9.73E-036P07766, P20963, P09693, P06239, Q04759, P01730CD3E, CD247, CD3G, LCK, PRKCQ, CD4More
Indinavirhsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Indinavirhsa05332Graft-versus-host disease3.93E-023P13765, P26715, Q13241HLA-DOB, KLRC1, KLRD1More
Indinavirhsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Indinavirhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Indinavir (SDC: 5.38)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)