PharmaCoNets of Indecainide (SPCN: 52.50 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Indecainidehsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Indecainidehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Indecainidehsa00270Cysteine and methionine metabolism1.92E-022Q96RQ9, P40926IL4I1, MDH2More
Indecainidehsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Indecainidehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Indecainidehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Indecainidehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Indecainidehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Indecainidehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Indecainidehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Indecainidehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Indecainidehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Indecainidehsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Indecainidehsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Indecainidehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Indecainidehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Indecainidehsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Indecainidehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Indecainidehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Indecainidehsa04010MAPK signaling pathway4.76E-025Q15283, P21860, Q12933, P01584, O14944RASA2, ERBB3, TRAF2, IL1B, EREGMore
Indecainidehsa04020Calcium signaling pathway3.61E-024Q96DU7, Q08828, Q13557, P21860ITPKC, ADCY1, CAMK2D, ERBB3More
Indecainidehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Indecainidehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Indecainidehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Indecainidehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Indecainidehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Indecainidehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Indecainidehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Indecainidehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Indecainidehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Indecainidehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Indecainidehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Indecainidehsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Indecainidehsa04530Tight junction3.60E-035P63261, P16989, P56750, Q92974, Q14247ACTG1, CSDA, CLDN17, ARHGEF2, CTTNMore
Indecainidehsa04613Neutrophil extracellular trap formation2.18E-037P04908, Q93077, P62807, O60814, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Indecainidehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Indecainidehsa04650Natural killer cell mediated cytotoxicity1.30E-0411P16298, P50591, P19174, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931PPP3CB, TNFSF10, PLCG1, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3More
Indecainidehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Indecainidehsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Indecainidehsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Indecainidehsa04668TNF signaling pathway1.26E-024Q12933, Q99941, P01584, O95429TRAF2, CREBL1, IL1B, BAG4More
Indecainidehsa04713Circadian entrainment4.25E-023Q13557, Q02153, Q08828CAMK2D, GUCY1B3, ADCY1More
Indecainidehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Indecainidehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Indecainidehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Indecainidehsa04750Inflammatory mediator regulation of TRP channels8.18E-048P14778, P01584, Q08828, Q13557, P19174, P42338, P24723, Q04759IL1R1, IL1B, ADCY1, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQMore
Indecainidehsa04911Insulin secretion2.23E-023Q08828, Q99941, Q13557ADCY1, CREBL1, CAMK2DMore
Indecainidehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Indecainidehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Indecainidehsa04932Non-alcoholic fatty liver disease2.44E-049P01375, P49841, P48023, Q12933, P01584, P12074, O15239, Q16718, O14521TNF, GSK3B, FASLG, TRAF2, IL1B, COX6A1, NDUFA1, NDUFA5, SDHDMore
Indecainidehsa04934Cushing syndrome6.07E-034Q99941, Q08828, O15169, Q13557CREBL1, ADCY1, AXIN1, CAMK2DMore
Indecainidehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Indecainidehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Indecainidehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Indecainidehsa05010Alzheimer disease1.23E-028Q92542, O15239, P05496, P12074, P01584, Q12933, O15169, P43686NCSTN, NDUFA1, ATP5G1, COX6A1, IL1B, TRAF2, AXIN1, PSMC4More
Indecainidehsa05012Parkinson disease3.53E-026P62987, O15239, P12074, P05496, P43686, Q13557UBA52, NDUFA1, COX6A1, ATP5G1, PSMC4, CAMK2DMore
Indecainidehsa05014Amyotrophic lateral sclerosis2.99E-027O15239, P12074, P05496, Q12933, P43686, P37198, P35658NDUFA1, COX6A1, ATP5G1, TRAF2, PSMC4, NUP62, NUP214More
Indecainidehsa05020Prion disease1.94E-0311P01584, P46531, O15239, Q16718, O14521, P05496, P12074, P43686, P49841, Q99941, Q16539IL1B, NOTCH1, NDUFA1, NDUFA5, SDHD, ATP5G1, COX6A1, PSMC4, GSK3B, CREBL1, MAPK14More
Indecainidehsa05022Pathways of neurodegeneration - multiple diseases2.29E-0415P49841, O15239, Q16718, O14521, P12074, P05496, Q12933, Q13561, Q16539, O15169, P01584, Q08752, Q13557, P62987, P43686GSK3B, NDUFA1, NDUFA5, SDHD, COX6A1, ATP5G1, TRAF2, DCTN2, MAPK14, AXIN1, IL1B, PPID, CAMK2D, UBA52, PSMC4More
Indecainidehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Indecainidehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Indecainidehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Indecainidehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Indecainidehsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Indecainidehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Indecainidehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Indecainidehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Indecainidehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Indecainidehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Indecainidehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Indecainidehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Indecainidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Indecainidehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Indecainidehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Indecainidehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Indecainidehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Indecainide (SDC: 5.64)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P11511CYP19A1AromatasePredicted00.815610.15882.5666
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
Q6V1X1DPP8Dipeptidyl peptidase 8Predicted00.28410.125900.3939
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)