PharmaCoNets of Indapamide (SPCN: 93.26 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Indapamidehsa00020Citrate cycle (TCA cycle)2.78E-022O75390, P40926CS, MDH2More
Indapamidehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Indapamidehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Indapamidehsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Indapamidehsa00565Ether lipid metabolism3.52E-042Q9Y6K0, Q8N661CEPT1, TMEM86BMore
Indapamidehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Indapamidehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Indapamidehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Indapamidehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Indapamidehsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Indapamidehsa00970Aminoacyl-tRNA biosynthesis2.48E-023O95363, P54136, Q15046FARS2, RARS1, KARSMore
Indapamidehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Indapamidehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Indapamidehsa00983Drug metabolism - other enzymes4.06E-022P20839, Q16772IMPDH1, GSTA3More
Indapamidehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Indapamidehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Indapamidehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Indapamidehsa01522Endocrine resistance3.41E-026P14780, P22694, Q9UM47, P08069, P10415, Q13323MMP9, PRKACB, NOTCH3, IGF1R, BCL2, BIKMore
Indapamidehsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Indapamidehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Indapamidehsa03013RNA transport3.40E-0315P62826, P52298, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, Q14152, O75822, P78345, Q13310, P20042, Q9Y6A5RAN, NCBP2, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EIF3A, EIF3J, RPP38, PABPC4, EIF2S2, TACC3More
Indapamidehsa03015mRNA surveillance pathway4.25E-024Q13310, Q13362, Q15287, Q9UBU9PABPC4, PPP2R5C, RNPS1, NXF1More
Indapamidehsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Indapamidehsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Indapamidehsa04015Rap1 signaling pathway2.99E-021P08069IGF1RMore
Indapamidehsa04020Calcium signaling pathway4.11E-036Q96DU7, Q08828, Q13557, P61073, P05141, P51828ITPKC, ADCY1, CAMK2D, CXCR4, SLC25A5, ADCY7More
Indapamidehsa04061Viral protein interaction with cytokine and cytokine receptor1.28E-028P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P09603, P01375CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, CSF1, TNFMore
Indapamidehsa04062Chemokine signaling pathway2.45E-0211P25024, P25025, P09341, P47992, Q9UBD3, P07948, P63218, P50151, Q08881, P22694, P49841CXCR1, CXCR2, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, ITK, PRKACB, GSK3BMore
Indapamidehsa04064NF-kappa B signaling pathway1.26E-0618P10415, Q13489, P51617, O00463, P14778, P01584, P01375, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P24522, P09341, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, IL1R1, IL1B, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, GADD45A, CXCL1, CYLDMore
Indapamidehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Indapamidehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Indapamidehsa04071Sphingolipid signaling pathway1.24E-078P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Indapamidehsa04080Neuroactive ligand-receptor interaction1.43E-0410P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2More
Indapamidehsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Indapamidehsa04114Oocyte meiosis9.85E-036Q13557, Q08828, P51828, P27348, Q13362, P08069CAMK2D, ADCY1, ADCY7, YWHAQ, PPP2R5C, IGF1RMore
Indapamidehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Indapamidehsa04140Autophagy - animal6.13E-048P08069, Q9Y4H2, Q9NQL2, P22694, Q14643, P10415, Q9H1Y0, Q04759IGF1R, IRS2, RRAGD, PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Indapamidehsa04145Phagosome1.45E-038O75015, Q15080, P14598, Q13509, P05164, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, MPO, TLR2, THBS4, HLA-DOBMore
Indapamidehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Indapamidehsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Indapamidehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Indapamidehsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Indapamidehsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Indapamidehsa04213Longevity regulating pathway - multiple species1.66E-021P08069IGF1RMore
Indapamidehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Indapamidehsa04261Adrenergic signaling in cardiomyocytes2.34E-037P07550, Q08828, P51828, P22694, P18848, Q13362, Q13557ADRB2, ADCY1, ADCY7, PRKACB, ATF4, PPP2R5C, CAMK2DMore
Indapamidehsa04340Hedgehog signaling pathway2.62E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Indapamidehsa04380Osteoclast differentiation2.05E-0312Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Indapamidehsa04510Focal adhesion3.48E-021P08069IGF1RMore
Indapamidehsa04520Adherens junction8.29E-031P08069IGF1RMore
Indapamidehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Indapamidehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Indapamidehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Indapamidehsa04612Antigen processing and presentation3.47E-059P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Indapamidehsa04613Neutrophil extracellular trap formation4.56E-0823P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Indapamidehsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Indapamidehsa04621NOD-like receptor signaling pathway1.54E-0313Q16539, Q14643, P21796, P10599, Q9H1Y0, P43490, O00463, P10415, P29728, Q05823, P01375, P09341, P12838MAPK14, ITPR1, VDAC1, TXN, ATG5, PBEF1, TRAF5, BCL2, OAS2, RNASEL, TNF, CXCL1, DEFA4More
Indapamidehsa04625C-type lectin receptor signaling pathway8.11E-039Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Indapamidehsa04640Hematopoietic cell lineage5.36E-0516P13612, P14778, P27930, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P09603, P01584ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, CSF1, IL1BMore
Indapamidehsa04650Natural killer cell mediated cytotoxicity7.65E-0711P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Indapamidehsa04657IL-17 signaling pathway3.14E-0510O00463, Q16539, P49841, P09341, P19875, P14780, Q9UJX4, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, ANAPC5, LCN2, TNF, IL1BMore
Indapamidehsa04658Th1 and Th2 cell differentiation2.05E-0912Q04759, P07766, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOB, JAK1, RUNX3More
Indapamidehsa04659Th17 cell differentiation1.25E-0512Q04759, Q16539, P06239, P13765, P14778, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458PRKCQ, MAPK14, LCK, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1More
Indapamidehsa04660T cell receptor signaling pathway2.01E-0814P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Indapamidehsa04666Fc gamma R-mediated phagocytosis3.08E-025O75015, P06396, O14494, P14598, P17252FCGR3B, GSN, PLPP1, NCF1, PRKCAMore
Indapamidehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Indapamidehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Indapamidehsa04723Retrograde endocannabinoid signaling4.40E-025Q14643, P63218, P50151, P22694, Q16539ITPR1, GNG5, GNG10, PRKACB, MAPK14More
Indapamidehsa04725Cholinergic synapse2.45E-024Q08828, P51828, P18848, Q13557ADCY1, ADCY7, ATF4, CAMK2DMore
Indapamidehsa04730Long-term depression1.16E-021P08069IGF1RMore
Indapamidehsa04750Inflammatory mediator regulation of TRP channels4.12E-0511P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, Q14643, P24723, Q04759, P0DP24IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, ITPR1, PRKCH, PRKCQ, CALM2More
Indapamidehsa04911Insulin secretion4.73E-034Q08828, P51828, P18848, Q13557ADCY1, ADCY7, ATF4, CAMK2DMore
Indapamidehsa04912GnRH signaling pathway4.27E-039Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP24, P22694ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM2, PRKACBMore
Indapamidehsa04913Ovarian steroidogenesis7.72E-033P42330, P22694, P08069AKR1C3, PRKACB, IGF1RMore
Indapamidehsa04914Progesterone-mediated oocyte maturation2.16E-021P08069IGF1RMore
Indapamidehsa04916Melanogenesis3.73E-023Q13557, Q08828, P51828CAMK2D, ADCY1, ADCY7More
Indapamidehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Indapamidehsa04924Renin secretion8.77E-043P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Indapamidehsa04925Aldosterone synthesis and secretion1.77E-024P18848, Q08828, P51828, Q13557ATF4, ADCY1, ADCY7, CAMK2DMore
Indapamidehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Indapamidehsa04927Cortisol synthesis and secretion1.12E-034P18848, Q08828, P51828, P22694ATF4, ADCY1, ADCY7, PRKACBMore
Indapamidehsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Indapamidehsa04932Non-alcoholic fatty liver disease1.18E-038P01375, P49841, P18848, P48023, O75460, P01584, P12074, O15239TNF, GSK3B, ATF4, FASLG, ERN1, IL1B, COX6A1, NDUFA1More
Indapamidehsa04934Cushing syndrome1.22E-024P18848, Q08828, P51828, Q13557ATF4, ADCY1, ADCY7, CAMK2DMore
Indapamidehsa04940Type I diabetes mellitus2.61E-034P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Indapamidehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Indapamidehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Indapamidehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Indapamidehsa04971Gastric acid secretion4.73E-034Q08828, P51828, P15311, Q13557ADCY1, ADCY7, VIL2, CAMK2DMore
Indapamidehsa05010Alzheimer disease1.50E-029O15239, P05496, P12074, Q00535, O75460, P01584, P18848, P05141, P28070NDUFA1, ATP5G1, COX6A1, CDK5, ERN1, IL1B, ATF4, SLC25A5, PSMB4More
Indapamidehsa05012Parkinson disease1.20E-028O15239, P12074, P05496, P05141, O75460, P18848, P28070, Q13557NDUFA1, COX6A1, ATP5G1, SLC25A5, ERN1, ATF4, PSMB4, CAMK2DMore
Indapamidehsa05016Huntington disease1.72E-028O15239, P12074, P05496, P30876, P62487, P05141, O75460, P28070NDUFA1, COX6A1, ATP5G1, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Indapamidehsa05020Prion disease3.72E-028P01584, P46531, O15239, P05496, P12074, P18848, P05141, P28070IL1B, NOTCH1, NDUFA1, ATP5G1, COX6A1, ATF4, SLC25A5, PSMB4More
Indapamidehsa05022Pathways of neurodegeneration - multiple diseases1.74E-0210O15239, P12074, P05496, O75460, P18848, P05141, Q00535, P01584, Q13557, P28070NDUFA1, COX6A1, ATP5G1, ERN1, ATF4, SLC25A5, CDK5, IL1B, CAMK2D, PSMB4More
Indapamidehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Indapamidehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Indapamidehsa05120Epithelial cell signaling in Helicobacter pylori infection2.84E-025Q16539, P09341, P25024, P25025, P07948MAPK14, CXCL1, CXCR1, CXCR2, LYNMore
Indapamidehsa05131Shigellosis3.15E-0212P01375, O00463, P14778, Q16539, Q04759, P61088, Q9NQL2, Q9H1Y0, P12814, Q14643, P49841, P21796TNF, TRAF5, IL1R1, MAPK14, PRKCQ, UBE2N, RRAGD, ATG5, ACTN1, ITPR1, GSK3B, VDAC1More
Indapamidehsa05133Pertussis4.20E-021P0C0L4C4AMore
Indapamidehsa05140Leishmaniasis5.35E-0511P13612, O75015, P14598, P23458, P13765, O60603, P01375, P01584, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, JAK1, HLA-DOB, TLR2, TNF, IL1B, MAPK14, IRAK1, NCF4More
Indapamidehsa05143African trypanosomiasis8.62E-054P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Indapamidehsa05144Malaria2.43E-048P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1More
Indapamidehsa05146Amoebiasis2.23E-0512P01584, P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Indapamidehsa05150Staphylococcus aureus infection9.78E-049P21730, P21462, O75015, P13765, Q16581, Q14532, P59665, P59666, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Indapamidehsa05152Tuberculosis8.54E-039O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Indapamidehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Indapamidehsa05163Human cytomegalovirus infection1.38E-0317P01375, P63218, P50151, Q14643, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, P18848, O00463TNF, GNG5, GNG10, ITPR1, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, ATF4, TRAF5More
Indapamidehsa05168Herpes simplex virus 1 infection4.79E-028P25963, Q07955, Q01130, Q9Y2A4, P51522, P17038, P52738, O75820NFKBIA, SFRS1, SFRS2, ZNF443, ZNF83, ZNF43, ZNF140, ZNF189More
Indapamidehsa05169Epstein-Barr virus infection2.52E-0212P13765, Q13547, O00463, Q16539, P07948, Q13761, P24522, P01375, P29728, P07766, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, LYN, RUNX3, GADD45A, TNF, OAS2, CD3E, CD3G, CD247More
Indapamidehsa05202Transcriptional misregulation in cancer2.88E-0824Q12778, Q15532, Q13315, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Indapamidehsa05203Viral carcinogenesis8.57E-038P18848, P23458, P27348, Q7KZF4, Q15283, P61978, P62807, O60814ATF4, JAK1, YWHAQ, SND1, RASA2, HNRPK, HIST1H2BC, H2BC12More
Indapamidehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Indapamidehsa05205Proteoglycans in cancer1.09E-026P14780, P01375, P08069, P23588, Q13635, P22694MMP9, TNF, IGF1R, EIF4B, PTCH1, PRKACBMore
Indapamidehsa05214Glioma9.95E-031P08069IGF1RMore
Indapamidehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Indapamidehsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Indapamidehsa05218Melanoma6.63E-031P08069IGF1RMore
Indapamidehsa05224Breast cancer1.49E-021P08069IGF1RMore
Indapamidehsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Indapamidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.93E-0410O95267, P07766, P20963, P09693, P06239, P23458, O60603, P10747, Q04759, Q16539RASGRP1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, CD28, PRKCQ, MAPK14More
Indapamidehsa05310Asthma4.16E-053P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Indapamidehsa05321Inflammatory bowel disease1.45E-107O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Indapamidehsa05322Systemic lupus erythematosus1.24E-0413O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Indapamidehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Indapamidehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Indapamidehsa05332Graft-versus-host disease1.01E-086P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Indapamidehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Indapamide (SDC: 5.79)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P35790CHKACholine kinase alphaPredicted00.5830.03390.16390.5233
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P63279UBE2ISUMONoneconjugating enzyme UBC9Predicted00.23320.05120.49830.7173
Q16875PFKFB36NonephosphofructoNone2Nonekinase/fructoseNone2,6Nonebisphosphatase 3Predicted10.04620.08860.23420.4345
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)