PharmaCoNets of Indacaterol (SPCN: 32.50 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Indacaterolhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Indacaterolhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Indacaterolhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Indacaterolhsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Indacaterolhsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Indacaterolhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Indacaterolhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Indacaterolhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Indacaterolhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Indacaterolhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Indacaterolhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Indacaterolhsa04071Sphingolipid signaling pathway6.08E-045P21453, Q9H228, P01375, Q13362, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Indacaterolhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Indacaterolhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Indacaterolhsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Indacaterolhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Indacaterolhsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Indacaterolhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Indacaterolhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Indacaterolhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Indacaterolhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Indacaterolhsa04613Neutrophil extracellular trap formation3.76E-0410P11215, Q13547, P04908, Q93077, P58876, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Indacaterolhsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Indacaterolhsa04657IL-17 signaling pathway2.10E-035P49841, P19875, P14780, P80188, P01375GSK3B, CXCL2, MMP9, LCN2, TNFMore
Indacaterolhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Indacaterolhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Indacaterolhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Indacaterolhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Indacaterolhsa04742Taste transduction1.01E-021P30939HTR1FMore
Indacaterolhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Indacaterolhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Indacaterolhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Indacaterolhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Indacaterolhsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Indacaterolhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Indacaterolhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Indacaterolhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Indacaterolhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Indacaterolhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Indacaterolhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Indacaterolhsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Indacaterolhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Indacaterolhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Indacaterolhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Indacaterolhsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Indacaterolhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Indacaterolhsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Indacaterolhsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Indacaterolhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Indacaterolhsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Indacaterolhsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Indacaterolhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Indacaterolhsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Indacaterolhsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Indacaterolhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Indacaterolhsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Indacaterolhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Indacaterol (SDC: 4.47)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
ADRB2P07550Ki16
ADRB2P07550Ki21
ADRB2P07550Ki61