PharmaCoNets of Imiquimod (SPCN: 260.90 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Imiquimodhsa00010Glycolysis / Gluconeogenesis3.47E-047P04075, P14550, P11766, P07195, P06733, P04406, P60174ALDOA, AKR1A1, ADH5, LDHB, ENO1, GAPDH, TPI1More
Imiquimodhsa00020Citrate cycle (TCA cycle)1.71E-034P50213, O75390, P40926, O14521IDH3A, CS, MDH2, SDHDMore
Imiquimodhsa00030Pentose phosphate pathway1.80E-094P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Imiquimodhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Imiquimodhsa00051Fructose and mannose metabolism2.11E-066P15121, P19367, O14772, P08237, P60174, P04075AKR1B1, HK1, FPGT, PFKM, TPI1, ALDOAMore
Imiquimodhsa00052Galactose metabolism5.22E-067P06280, P08237, O43451, P15121, P35557, P19367, Q14376GLA, PFKM, MGAM, AKR1B1, GCK, HK1, GALEMore
Imiquimodhsa00061Fatty acid biosynthesis4.83E-021P33121ACSL1More
Imiquimodhsa00071Fatty acid degradation2.38E-023P11310, O75521, P33121ACADM, ECI2, ACSL1More
Imiquimodhsa00072Synthesis and degradation of ketone bodies2.78E-021Q01581HMGCS1More
Imiquimodhsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Imiquimodhsa00190Oxidative phosphorylation3.29E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Imiquimodhsa00220Arginine biosynthesis2.76E-053P15104, P05089, P49448GLUL, ARG1, GLUD2More
Imiquimodhsa00230Purine metabolism2.92E-034Q7LG56, P31350, P51828, P21589RRM2B, RRM2, ADCY7, NT5EMore
Imiquimodhsa00240Pyrimidine metabolism2.54E-043P31350, P21589, P04818RRM2, NT5E, TYMSMore
Imiquimodhsa00250Alanine, aspartate and glutamate metabolism6.84E-053Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Imiquimodhsa00270Cysteine and methionine metabolism2.39E-022Q96RQ9, P40926IL4I1, MDH2More
Imiquimodhsa00280Valine, leucine and isoleucine degradation1.93E-046P55809, Q9HCC0, Q96RQ9, P05166, Q02252, P11310OXCT1, MCCC2, IL4I1, PCCB, ALDH6A1, ACADMMore
Imiquimodhsa00310Lysine degradation1.30E-067Q9NVH6, Q96KQ7, Q8NEZ4, Q13029, O15047, Q02809, P51648TMLHE, EHMT2, MLL3, PRDM2, SETD1A, PLOD1, ALDH3A2More
Imiquimodhsa00330Arginine and proline metabolism2.73E-021P17707AMD1More
Imiquimodhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Imiquimodhsa00380Tryptophan metabolism3.02E-021Q16613AANATMore
Imiquimodhsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Imiquimodhsa00471D-Glutamine and D-glutamate metabolism1.54E-032Q7Z3D6, P49448C14orf159, GLUD2More
Imiquimodhsa00500Starch and sucrose metabolism4.14E-084O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Imiquimodhsa00510N-Glycan biosynthesis1.10E-034O94777, P15907, Q9BVK2, Q9NR34DPM2, ST6GAL1, ALG8, MAN1C1More
Imiquimodhsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Imiquimodhsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Imiquimodhsa00520Amino sugar and nucleotide sugar metabolism2.98E-053Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Imiquimodhsa00524Neomycin, kanamycin and gentamicin biosynthesis1.27E-021P35557GCKMore
Imiquimodhsa00531Glycosaminoglycan degradation3.78E-021P15586GNSMore
Imiquimodhsa00562Inositol phosphate metabolism4.54E-045Q9NRR6, P27987, O14732, P19174, P42338INPP5E, ITPKB, IMPA2, PLCG1, PIK3CBMore
Imiquimodhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.28E-032O94777, Q14442DPM2, PIGHMore
Imiquimodhsa00564Glycerophospholipid metabolism3.90E-068P48651, Q9Y6K0, P35790, Q9Y259, P23743, P49619, O14494, Q3LIE5PTDSS1, CEPT1, CHKA, CHKB, DGKA, DGKG, PLPP1, ADPRMMore
Imiquimodhsa00590Arachidonic acid metabolism2.97E-021P09917ALOX5More
Imiquimodhsa00600Sphingolipid metabolism1.99E-044Q9BX95, Q06136, P06280, P15289SGPP1, FVT1, GLA, ARSAMore
Imiquimodhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.27E-072P06865, O75752HEXA, B3GALNT1More
Imiquimodhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Imiquimodhsa00620Pyruvate metabolism9.80E-044P40926, P07195, P14550, P11766MDH2, LDHB, AKR1A1, ADH5More
Imiquimodhsa00630Glyoxylate and dicarboxylate metabolism8.62E-104P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Imiquimodhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Imiquimodhsa00670One carbon pool by folate1.56E-064O95954, P00374, P04818, Q99707FTCD, DHFR, TYMS, MTRMore
Imiquimodhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Imiquimodhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Imiquimodhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Imiquimodhsa00770Pantothenate and CoA biosynthesis3.98E-021Q6ZQY3GADL1More
Imiquimodhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Imiquimodhsa00790Folate biosynthesis7.87E-044P00374, Q92820, P05186, P42330DHFR, GGH, ALPL, AKR1C3More
Imiquimodhsa00830Retinol metabolism3.35E-045P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Imiquimodhsa00860Porphyrin and chlorophyll metabolism2.26E-033P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Imiquimodhsa00900Terpenoid backbone biosynthesis9.84E-043Q01581, P49354, Q9UHG3HMGCS1, FNTA, PCYOX1More
Imiquimodhsa00910Nitrogen metabolism4.40E-032P15104, P49448GLUL, GLUD2More
Imiquimodhsa00970Aminoacyl-tRNA biosynthesis2.45E-053O95363, P54136, P14868FARS2, RARS1, DARSMore
Imiquimodhsa00983Drug metabolism - other enzymes9.69E-085P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Imiquimodhsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Imiquimodhsa01100Metabolic pathways1.38E-0882Q9NR34, Q9Y234, P35790, Q9Y259, P05089, P21953, Q16772, Q9UJ14, P15144, P30041, P15104, P19367, P42338, Q9Y217, P48426, P27987, Q96DU7, P22557, Q6ZQY3, P32320, Q08828, Q13956, Q02153, P20839, P22748, P40926, P55809, P06280, O94777, Q16875, O43286, O43451, P53004, Q9Y6K0, P05186, P24666, P15121, P08237, P49619, Q86XP1, O95861, Q96RQ9, O95954, Q9HCC0, P33121, Q02318, Q9UHK6, P42330, Q13093, Q86VZ5, Q96G23, P09917, P48651, Q9BVK2, Q9NY28, P57054, Q14442, Q9UBX8, Q9UNP4, Q9H4F1, Q9BX95, P09960, Q9BRR6, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737, Q969G6, P05166, P14927, P12074, P05496, Q99437, O15239, Q16718, O15047, Q9NVH6MAN1C1, LIPT1, CHKA, CHKB, ARG1, BCKDHB, GSTA3, GGTL3, ANPEP, PRDX6, GLUL, HK1, PIK3CB, MTMR6, PIP4K2A, ITPKB, ITPKC, ALAS2, GADL1, CDA, ADCY1, PDE6H, GUCY1B3, IMPDH1, CA4, MDH2, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, BLVRA, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKG, DGKH, BPNT1, IL4I1, FTCD, MCCC2, ACSL1, CYP27A1, AMACR, AKR1C3, PLA2G7, SGMS1, LASS2, ALOX5, PTDSS1, ALG8, GALNT8, PIGP, PIGH, B4GALT6, ST3GAL5, ST6GALNAC4, SGPP1, LTA4H, ADPGK, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGL, RFK, PCCB, UQCRB, COX6A1, ATP5G1, ATP6V0B, NDUFA1, NDUFA5, SETD1A, TMLHEMore
Imiquimodhsa01200Carbon metabolism1.03E-039P04075, P04406, P52209, P60174, P37837, P06733, O14521, Q9P2R7, Q02252ALDOA, GAPDH, PGD, TPI1, TALDO1, ENO1, SDHD, SUCLA2, ALDH6A1More
Imiquimodhsa01212Fatty acid metabolism4.62E-022P33121, P11310ACSL1, ACADMMore
Imiquimodhsa01230Biosynthesis of amino acids5.83E-0610P60174, P04406, P06733, P04075, P51854, P60891, Q99707, P50213, P05089, P37837TPI1, GAPDH, ENO1, ALDOA, TKTL1, PRPS1, MTR, IDH3A, ARG1, TALDO1More
Imiquimodhsa01240Biosynthesis of cofactors2.85E-047Q969G6, P13716, P36551, P22557, O60701, P14618, Q9Y234RFK, ALAD, CPOX, ALAS2, UGDH, PKM2, LIPT1More
Imiquimodhsa01521EGFR tyrosine kinase inhibitor resistance3.45E-044P49841, P04049, P08069, Q9NRA1GSK3B, RAF1, IGF1R, PDGFCMore
Imiquimodhsa01522Endocrine resistance1.02E-047P04049, Q9UM47, P04637, P42773, P08069, P10415, Q13323RAF1, NOTCH3, TP53, CDKN2C, IGF1R, BCL2, BIKMore
Imiquimodhsa01523Antifolate resistance5.68E-064P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Imiquimodhsa01524Platinum drug resistance2.37E-058Q13489, Q14790, P48023, P78417, P40692, P23025, P52701, P31751BIRC3, CASP8, FASLG, GSTO1, MLH1, XPA, MSH6, AKT2More
Imiquimodhsa02010ABC transporters4.48E-021Q8IZY2ABCA7More
Imiquimodhsa03010Ribosome2.33E-1118P26373, P62753, P42677, P25398, P32969, P62917, P46776, Q9H0U6, Q07020, P62899, P62910, P18077, P61927, Q02878, P36578, P27635, P05386, P23396RPL13, RPS6, RPS27, RPS12, RPL9, RPL8, RPL27A, MRPL18, RPL18, RPL31, RPL32, RPL35A, RPL37, RPL6, RPL4, RPL10, RPLP1, RPS3More
Imiquimodhsa03013RNA transport1.05E-1830P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, Q9H777, P11940, Q13310, P20042, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, ELAC1, PABPC1, PABPC4, EIF2S2, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, FXR1More
Imiquimodhsa03015mRNA surveillance pathway5.50E-036Q9BZI7, Q13310, Q13362, O94913, Q15287, Q9UBU9UPF3B, PABPC4, PPP2R5C, PCF11, RNPS1, NXF1More
Imiquimodhsa03020RNA polymerase3.17E-116P30876, P24928, P62487, Q9GZM3, P52435, Q9Y535POLR2B, POLR2A, POLR2G, POLR2J2, POLR2J, POLR3HMore
Imiquimodhsa03022Basal transcription factors2.41E-021Q12962TAF10More
Imiquimodhsa03040Spliceosome3.37E-0815Q14562, O43143, O60508, P08579, P26368, O75940, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, SMNDC1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Imiquimodhsa03060Protein export5.79E-114Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Imiquimodhsa03320PPAR signaling pathway2.95E-045Q6PCB7, Q13418, Q9UNU6, Q13133, Q02318SLC27A1, ILK, CYP8B1, NR1H3, CYP27A1More
Imiquimodhsa03430Mismatch repair4.38E-021P20585MSH3More
Imiquimodhsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Imiquimodhsa03460Fanconi anemia pathway8.90E-043P40692, O60673, Q9UNA4MLH1, REV3L, POLIMore
Imiquimodhsa04010MAPK signaling pathway8.69E-054P04049, P08069, Q9H2K8, Q12933RAF1, IGF1R, TAOK3, TRAF2More
Imiquimodhsa04012ErbB signaling pathway3.84E-067Q13153, P16333, Q13191, P19174, P42338, P01106, P04049PAK1, NCK1, CBLB, PLCG1, PIK3CB, MYC, RAF1More
Imiquimodhsa04014Ras signaling pathway1.07E-0410P04049, P31751, Q9NRA1, P08069, Q13009, P0DP23, P62873, P63218, P50151, P19174RAF1, AKT2, PDGFC, IGF1R, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Imiquimodhsa04015Rap1 signaling pathway1.82E-0511P04049, P09603, Q9GZP0, P08069, P06213, P11215, O00522, P31751, P0DP23, Q86WV1, P19174RAF1, CSF1, PDGFD, IGF1R, INSR, ITGAM, KRIT1, AKT2, CALM1, SKAP1, PLCG1More
Imiquimodhsa04020Calcium signaling pathway4.43E-0813Q96DU7, Q08828, P21796, P45880, Q13557, P21860, P30679, P61073, P0DP24, P0DP23, P05141, P51828, P23634ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, ERBB3, GNA15, CXCR4, CALM2, CALM1, SLC25A5, ADCY7, ATP2B4More
Imiquimodhsa04022cGMP-PKG signaling pathway1.32E-0712Q02153, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Imiquimodhsa04024cAMP signaling pathway5.16E-0610P49019, Q08828, P51828, P22694, P31751, P0DP23, P20020, P04049, P48058, Q13153HCAR3, ADCY1, ADCY7, PRKACB, AKT2, CALM1, ATP2B1, RAF1, GRIA4, PAK1More
Imiquimodhsa04060Cytokine-cytokine receptor interaction6.46E-0517P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, P09341, P19875, P80075, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CXCL2, CCL8, CD4, TNFRSF25More
Imiquimodhsa04061Viral protein interaction with cytokine and cytokine receptor1.05E-0610Q8NHW4, P09341, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Imiquimodhsa04062Chemokine signaling pathway3.15E-0718P25024, P09341, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q13009, P14598, P42224, P04049, P25963CXCR1, CXCL1, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, TIAM1, NCF1, STAT1, RAF1, NFKBIAMore
Imiquimodhsa04064NF-kappa B signaling pathway1.16E-1724P10415, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, P67870, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, CSNK2B, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Imiquimodhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Imiquimodhsa04068FoxO signaling pathway4.41E-054P04049, P08069, P48023, Q96BR1RAF1, IGF1R, FASLG, SGK3More
Imiquimodhsa04070Phosphatidylinositol signaling system5.92E-0610P19174, P0DP23, O14986, P23743, P49619, Q86XP1, Q16760, P48426, P27987, Q96DU7PLCG1, CALM1, PIP5K1B, DGKA, DGKG, DGKH, DGKD, PIP4K2A, ITPKB, ITPKCMore
Imiquimodhsa04071Sphingolipid signaling pathway1.38E-0510P04049, P21453, Q9H228, P01375, Q96G23, Q13362, Q9BX95, P10415, Q12933, Q02156RAF1, S1PR1, EDG8, TNF, LASS2, PPP2R5C, SGPP1, BCL2, TRAF2, PRKCEMore
Imiquimodhsa04072Phospholipase D signaling pathway4.96E-058P04049, P31751, Q9UQC2, O14986, Q15438, Q08828, P51828, Q16760RAF1, AKT2, GAB2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Imiquimodhsa04080Neuroactive ligand-receptor interaction2.70E-0716P08311, P78334, Q15722, P21453, Q9H228, P43657, O00398, Q01726, P41968, P21462, P21730, Q16581, P30939, P14416, P07550, P35318CTSG, GABRE, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, MC1R, MC3R, FPR1, C5AR1, C3AR1, HTR1F, DRD2, ADRB2, ADMMore
Imiquimodhsa04110Cell cycle1.99E-0912Q9UBD5, P30260, P06493, O60566, Q14683, P04637, P49918, P30304, P33981, P42773, P01106, Q13547ORC3, CDC27, CDK1, BUB1B, SMC1A, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Imiquimodhsa04114Oocyte meiosis6.42E-1113Q9Y6D9, P51812, Q02750, Q13557, P0DP23, P16298, Q17RY0, Q08828, P51828, P27348, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CAMK2D, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, YWHAQ, PPP2R5C, PPP2R5D, IGF1RMore
Imiquimodhsa04115p53 signaling pathway2.55E-048P24522, O15151, Q13315, P31350, Q53FA7, P06493, O95067, P10415GADD45A, MDM4, ATM, RRM2, TP53I3, CDK1, CCNB2, BCL2More
Imiquimodhsa04120Ubiquitin mediated proteolysis4.82E-032Q9UBT2, Q14669SAE2, TRIP12More
Imiquimodhsa04136Autophagy - other7.59E-032O94817, Q9H1Y0ATG12, ATG5More
Imiquimodhsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Imiquimodhsa04140Autophagy - animal3.90E-0515P08069, Q9Y4H2, P42338, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, PIK3CB, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Imiquimodhsa04141Protein processing in endoplasmic reticulum4.15E-0613P18848, Q12933, P30101, Q15436, P60604, Q99941, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9H173, Q9UNL2ATF4, TRAF2, PDIA3, SEC23A, UBE2G2, CREBL1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SIL1, SSR3More
Imiquimodhsa04142Lysosome1.11E-0511O14773, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916, Q04900TPP1, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2, CD164More
Imiquimodhsa04144Endocytosis8.76E-0719Q13191, P0DMV8, P11142, Q9H444, O43633, O75351, P62491, P25024, Q96B97, P43250, Q6WKZ4, Q15438, Q8WU79, Q14161, P14784, O95219, O75154, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, CHMP2A, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, RAB11FIP1, PSCD1, SMAP1L, GIT2, IL2RB, SNX4, RAB11FIP3, SNX12, SNX5More
Imiquimodhsa04145Phagosome1.29E-0613O75015, P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765FCGR3B, ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Imiquimodhsa04146Peroxisome1.43E-024O00623, P56589, Q9UKG9, P33121PEX12, PEX3, CROT, ACSL1More
Imiquimodhsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Imiquimodhsa04151PI3K-Akt signaling pathway5.77E-0830P62753, P21860, P43657, P01106, O43521, P04637, P27348, P09603, Q9GZP0, Q13362, P07900, P62873, P63218, P50151, P61952, P13612, P02452, P24821, Q16363, Q13751, P22105, P14784, P23458, P01568, Q99941, P18848, Q96BR1, O00141, Q6ZUJ8, P56279RPS6, ERBB3, P2RY5, MYC, BCL2L11, TP53, YWHAQ, CSF1, PDGFD, PPP2R5C, HSP90AA1, GNB1, GNG5, GNG10, GNG11, ITGA4, COL1A1, TNC, LAMA4, LAMB3, TNXB, IL2RB, JAK1, IFNA21, CREBL1, ATF4, SGK3, SGK, PIK3AP1, TCL1AMore
Imiquimodhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Imiquimodhsa04210Apoptosis5.51E-0412Q13315, P10415, O76075, Q14790, P48023, P24522, Q16548, P43234, P18848, Q14643, P42575, P04049ATM, BCL2, DFFB, CASP8, FASLG, GADD45A, BCL2A1, CTSO, ATF4, ITPR1, CASP2, RAF1More
Imiquimodhsa04211Longevity regulating pathway2.60E-046P31751, P08069, Q08828, P51828, P18848, Q96RR4AKT2, IGF1R, ADCY1, ADCY7, ATF4, CAMKK2More
Imiquimodhsa04213Longevity regulating pathway - multiple species1.23E-079P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Imiquimodhsa04217Necroptosis2.04E-1019Q12933, P01568, P23458, Q13489, Q9NQC7, Q13546, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q13557, Q9H444, O43633, O75351, P45880, Q08752TRAF2, IFNA21, JAK1, BIRC3, CYLD, RIPK1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, CAMK2D, CHMP4B, CHMP2A, VPS4B, VDAC2, PPIDMore
Imiquimodhsa04218Cellular senescence1.96E-047P31751, P04049, P30281, P0DP23, P01889, P10321, P12236AKT2, RAF1, CCND3, CALM1, HLA-B, HLA-C, SLC25A6More
Imiquimodhsa04260Cardiac muscle contraction4.06E-033P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Imiquimodhsa04261Adrenergic signaling in cardiomyocytes6.80E-0912P67936, Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP24, P0DP23, Q13557, P23634TPM4, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM2, CALM1, CAMK2D, ATP2B4More
Imiquimodhsa04270Vascular smooth muscle contraction1.71E-0611P24723, Q04759, Q14643, P0DP23, P04049, Q08828, P51828, P22694, P35579, P35749, P35318PRKCH, PRKCQ, ITPR1, CALM1, RAF1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADMMore
Imiquimodhsa04310Wnt signaling pathway2.28E-045P30279, Q13485, O43318, P17612, P67870CCND2, SMAD4, MAP3K7, PRKACA, CSNK2BMore
Imiquimodhsa04330Notch signaling pathway4.54E-044Q92542, P49768, P46531, Q9UM47NCSTN, PSEN1, NOTCH1, NOTCH3More
Imiquimodhsa04340Hedgehog signaling pathway2.58E-034P17612, P22694, Q13635, P10415PRKACA, PRKACB, PTCH1, BCL2More
Imiquimodhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Imiquimodhsa04360Axon guidance4.12E-047P16298, Q05397, Q13873, P42338, P04049, O14639, P24844PPP3CB, PTK2, BMPR2, PIK3CB, RAF1, ABLIM1, MYL9More
Imiquimodhsa04370VEGF signaling pathway6.18E-137P19174, P16298, P31751, P42338, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PTK2, MAP2K1, RAF1More
Imiquimodhsa04371Apelin signaling pathway6.52E-0714P62873, P63218, P50151, P61952, P31751, P04049, Q08828, P51828, Q13370, Q14344, P84022, P62753, P0DP23, P0DP24GNB1, GNG5, GNG10, GNG11, AKT2, RAF1, ADCY1, ADCY7, PDE3B, GNA13, SMAD3, RPS6, CALM1, CALM2More
Imiquimodhsa04380Osteoclast differentiation2.25E-0710Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Imiquimodhsa04390Hippo signaling pathway3.37E-055O95835, P04628, Q9UJU2, O43623, Q13489LATS1, WNT1, LEF1, SNAI2, BIRC3More
Imiquimodhsa04392Hippo signaling pathway - multiple species2.11E-053O95835, Q13153, Q6V0I7LATS1, PAK1, FAT4More
Imiquimodhsa04510Focal adhesion1.63E-035Q15942, P51636, P30281, P04049, P08069ZYX, CAV2, CCND3, RAF1, IGF1RMore
Imiquimodhsa04512ECM-receptor interaction2.77E-056P02452, P24821, P07359, P26012, P08514, P16070COL1A1, TNC, GP1BA, ITGB8, ITGA2B, CD44More
Imiquimodhsa04520Adherens junction1.81E-033Q13485, O43318, P08069SMAD4, MAP3K7, IGF1RMore
Imiquimodhsa04540Gap junction5.01E-055Q13509, P68371, Q71U36, P04049, Q9NRA1TUBB3, TUBB2C, TUBA1A, RAF1, PDGFCMore
Imiquimodhsa04550Signaling pathways regulating pluripotency of stem cells1.61E-035Q13873, P04049, Q02750, P08069, Q86SE9BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Imiquimodhsa04610Complement and coagulation cascades1.45E-084P09871, P0C0L4, P20023, P05107C1S, C4A, CR2, ITGB2More
Imiquimodhsa04611Platelet activation2.65E-056Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Imiquimodhsa04612Antigen processing and presentation6.12E-1112P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P30101, P11142, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, PDIA3, HSPA8, TNFMore
Imiquimodhsa04613Neutrophil extracellular trap formation4.35E-0723P19174, P04049, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q99878, P62807, Q16778, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PLCG1, RAF1, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC14, HIST1H2BC, HIST2H2BE, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Imiquimodhsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Imiquimodhsa04620Toll-like receptor signaling pathway2.48E-055Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Imiquimodhsa04621NOD-like receptor signaling pathway2.55E-0312P01584, P07900, Q14643, P23458, P45880, P10599, P43490, O00463, P29728, P01375, P09341, P12838IL1B, HSP90AA1, ITPR1, JAK1, VDAC2, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4More
Imiquimodhsa04622RIG-I-like receptor signaling pathway1.29E-075P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Imiquimodhsa04623Cytosolic DNA-sensing pathway6.85E-136P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2More
Imiquimodhsa04625C-type lectin receptor signaling pathway4.61E-0810Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Imiquimodhsa04630JAK-STAT signaling pathway1.01E-048P01106, P31751, P42224, P23458, P14784, P16871, Q13651, P04049MYC, AKT2, STAT1, JAK1, IL2RB, IL7R, IL10RA, RAF1More
Imiquimodhsa04640Hematopoietic cell lineage1.08E-1018P13612, P07359, P08514, P14778, P27930, P11215, P15144, P20023, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P09603ITGA4, GP1BA, ITGA2B, IL1R1, IL1R2, ITGAM, ANPEP, CR2, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, CSF1More
Imiquimodhsa04650Natural killer cell mediated cytotoxicity1.55E-2019P16298, P50591, P19174, P01375, P17252, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, PRKCA, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Imiquimodhsa04657IL-17 signaling pathway2.69E-0713P25963, P07900, P08238, O00463, Q12933, Q07955, Q16539, P49841, P09341, P14780, P80188, P01375, P06702NFKBIA, HSP90AA1, HSP90AB1, TRAF5, TRAF2, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, S100A9More
Imiquimodhsa04658Th1 and Th2 cell differentiation1.37E-3017P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, RUNX3More
Imiquimodhsa04659Th17 cell differentiation1.37E-2219P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Imiquimodhsa04660T cell receptor signaling pathway7.03E-2019P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Imiquimodhsa04662B cell receptor signaling pathway3.04E-1213P31751, P42338, P20023, P60033, P13164, P16298, Q8WV28, P07948, P11912, P21854, Q8N149, Q02750, P04049AKT2, PIK3CB, CR2, CD81, IFITM1, PPP3CB, BLNK, LYN, CD79A, CD72, LILRA2, MAP2K1, RAF1More
Imiquimodhsa04664Fc epsilon RI signaling pathway4.26E-0910P01375, P31751, P04141, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917TNF, AKT2, CSF2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5More
Imiquimodhsa04666Fc gamma R-mediated phagocytosis4.61E-034P08637, O75015, P04049, P06396FCGR3A, FCGR3B, RAF1, GSNMore
Imiquimodhsa04668TNF signaling pathway4.51E-0511P01375, Q12933, O00463, Q16539, Q99941, P18848, P01584, P20749, P14780, P20333, O95429TNF, TRAF2, TRAF5, MAPK14, CREBL1, ATF4, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Imiquimodhsa04710Circadian rhythm4.86E-021O15516CLOCKMore
Imiquimodhsa04713Circadian entrainment8.78E-0913P0DP23, P0DP24, Q13557, Q02153, P17252, P62873, P63218, P50151, P61952, P48058, Q08828, P51828, P22694CALM1, CALM2, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG5, GNG10, GNG11, GRIA4, ADCY1, ADCY7, PRKACBMore
Imiquimodhsa04714Thermogenesis3.95E-035P22694, Q16539, P33121, Q16718, O14521PRKACB, MAPK14, ACSL1, NDUFA5, SDHDMore
Imiquimodhsa04720Long-term potentiation5.72E-1010Q13557, P16298, P0DP23, P0DP24, Q15418, P51812, P18848, Q08828, Q02750, P04049CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1More
Imiquimodhsa04721Synaptic vesicle cycle3.77E-053Q13488, P43003, P31645TCIRG1, SLC1A3, SLC6A4More
Imiquimodhsa04722Neurotrophin signaling pathway9.79E-067Q05655, P31751, P04049, P52566, P51617, P10415, P0DP23PRKCD, AKT2, RAF1, ARHGDIB, IRAK1, BCL2, CALM1More
Imiquimodhsa04723Retrograde endocannabinoid signaling2.12E-048P17252, P62873, P61952, P48058, Q08828, P22694, O15239, Q16718PRKCA, GNB1, GNG11, GRIA4, ADCY1, PRKACB, NDUFA1, NDUFA5More
Imiquimodhsa04724Glutamatergic synapse6.46E-0810P48058, O15399, Q08828, P22694, P17252, P62873, P63218, P50151, P61952, P15104GRIA4, GRIN2D, ADCY1, PRKACB, PRKCA, GNB1, GNG5, GNG10, GNG11, GLULMore
Imiquimodhsa04725Cholinergic synapse8.02E-0813Q08828, P51828, P22694, Q14643, P62873, P63218, P50151, P61952, P18848, Q13557, P42338, P31751, P10415ADCY1, ADCY7, PRKACB, ITPR1, GNB1, GNG5, GNG10, GNG11, ATF4, CAMK2D, PIK3CB, AKT2, BCL2More
Imiquimodhsa04726Serotonergic synapse4.14E-048P22694, P17252, P31645, P62873, P63218, P50151, P09917, P04049PRKACB, PRKCA, SLC6A4, GNB1, GNG5, GNG10, ALOX5, RAF1More
Imiquimodhsa04727GABAergic synapse1.20E-099Q08828, P51828, P62873, P63218, P50151, P61952, P15104, P46459, Q15111ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, GLUL, NSF, PLCL1More
Imiquimodhsa04728Dopaminergic synapse9.23E-0916P62873, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP24, P0DP23, O15516, P48058GNB1, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM2, CALM1, CLOCK, GRIA4More
Imiquimodhsa04730Long-term depression4.37E-034Q14344, P08069, P04049, P07948GNA13, IGF1R, RAF1, LYNMore
Imiquimodhsa04740Olfactory transduction4.52E-054P62873, Q13557, P0DP23, P0DP24GNB1, CAMK2D, CALM1, CALM2More
Imiquimodhsa04742Taste transduction1.18E-032P30939, P17612HTR1F, PRKACAMore
Imiquimodhsa04744Phototransduction8.90E-093P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Imiquimodhsa04750Inflammatory mediator regulation of TRP channels4.55E-1011P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM2, CALM1More
Imiquimodhsa04810Regulation of actin cytoskeleton1.78E-026Q13009, P04049, P11215, P16144, P60709, P01042TIAM1, RAF1, ITGAM, ITGB4, ACTB, KNG1More
Imiquimodhsa04910Insulin signaling pathway2.40E-053P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Imiquimodhsa04911Insulin secretion7.78E-107Q08828, P51828, P22694, P17252, Q99941, P18848, Q13557ADCY1, ADCY7, PRKACB, PRKCA, CREBL1, ATF4, CAMK2DMore
Imiquimodhsa04912GnRH signaling pathway3.69E-078Q08828, P51828, P18848, Q13557, Q9Y6R4, P0DP23, P04049, P45985ADCY1, ADCY7, ATF4, CAMK2D, MAP3K4, CALM1, RAF1, MAP2K4More
Imiquimodhsa04913Ovarian steroidogenesis1.69E-044P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Imiquimodhsa04914Progesterone-mediated oocyte maturation1.58E-086P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Imiquimodhsa04915Estrogen signaling pathway3.14E-1016P14780, P22694, P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, Q14643, P0DP23, P0DP24, Q15788, P10415MMP9, PRKACB, RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, ITPR1, CALM1, CALM2, NCOA1, BCL2More
Imiquimodhsa04916Melanogenesis6.89E-067Q13557, P0DP23, Q08828, P51828, P49841, Q01726, P04049CAMK2D, CALM1, ADCY1, ADCY7, GSK3B, MC1R, RAF1More
Imiquimodhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Imiquimodhsa04918Thyroid hormone synthesis4.65E-068P22694, Q08828, P17252, Q99941, P18848, Q14643, P02768, P05543PRKACB, ADCY1, PRKCA, CREBL1, ATF4, ITPR1, ALB, SERPINA7More
Imiquimodhsa04919Thyroid hormone signaling pathway1.21E-047P19174, P04049, P42224, P60709, Q13547, Q9UM47, P01106PLCG1, RAF1, STAT1, ACTB, HDAC1, NOTCH3, MYCMore
Imiquimodhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Imiquimodhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Imiquimodhsa04922Glucagon signaling pathway4.86E-044P14618, P06737, P31751, P0DP23PKM2, PYGL, AKT2, CALM1More
Imiquimodhsa04923Regulation of lipolysis in adipocytes5.39E-064Q08828, P51828, P06213, P31751ADCY1, ADCY7, INSR, AKT2More
Imiquimodhsa04924Renin secretion3.14E-054P22694, P07550, Q14643, P0DP23PRKACB, ADRB2, ITPR1, CALM1More
Imiquimodhsa04925Aldosterone synthesis and secretion2.56E-1111Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, P17252, Q13557, P22694, P20020, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, PRKCA, CAMK2D, PRKACB, ATP2B1, ATP2B4More
Imiquimodhsa04926Relaxin signaling pathway1.62E-0714P31751, P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P49767, Q08828, P51828, P04049, P30679, P49407AKT2, PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, GNA15, ARRB1More
Imiquimodhsa04927Cortisol synthesis and secretion7.91E-086Q14643, Q99941, P18848, Q08828, P51828, P22694ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACBMore
Imiquimodhsa04928Parathyroid hormone synthesis, secretion and action9.56E-036Q14643, P22694, P23771, P04049, P18848, P10415ITPR1, PRKACB, GATA3, RAF1, ATF4, BCL2More
Imiquimodhsa04929GnRH secretion6.93E-064P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Imiquimodhsa04930Type II diabetes mellitus6.29E-053P06213, Q05655, Q02156INSR, PRKCD, PRKCEMore
Imiquimodhsa04932Non-alcoholic fatty liver disease1.14E-1312P31751, Q14790, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, O95298, P19404AKT2, CASP8, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2, NDUFV2More
Imiquimodhsa04934Cushing syndrome1.92E-086Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Imiquimodhsa04935Growth hormone synthesis, secretion and action5.87E-046Q08828, P51828, P04049, P18848, P31751, P45985ADCY1, ADCY7, RAF1, ATF4, AKT2, MAP2K4More
Imiquimodhsa04940Type I diabetes mellitus1.55E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Imiquimodhsa04950Maturity onset diabetes of the young1.27E-021P35557GCKMore
Imiquimodhsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Imiquimodhsa04961Endocrine and other factor-regulated calcium reabsorption9.85E-053P20020, P17252, P22694ATP2B1, PRKCA, PRKACBMore
Imiquimodhsa04962Vasopressin-regulated water reabsorption6.61E-032P22694, Q13561PRKACB, DCTN2More
Imiquimodhsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Imiquimodhsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Imiquimodhsa04970Salivary secretion7.02E-1112P07550, Q08828, P51828, P22694, Q14643, P20020, P23634, P17252, P0DP24, P0DP23, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B1, ATP2B4, PRKCA, CALM2, CALM1, GUCY1B3, CAMPMore
Imiquimodhsa04971Gastric acid secretion5.11E-096Q08828, P51828, P15311, P0DP24, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM2, CALM1, CAMK2DMore
Imiquimodhsa04972Pancreatic secretion1.48E-032P20020, P17252ATP2B1, PRKCAMore
Imiquimodhsa04973Carbohydrate digestion and absorption2.41E-021P31751AKT2More
Imiquimodhsa04974Protein digestion and absorption1.22E-032Q7Z2H8, P02452SLC36A1, COL1A1More
Imiquimodhsa04975Fat digestion and absorption4.83E-021O14494PLPP1More
Imiquimodhsa04976Bile secretion1.68E-066O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Imiquimodhsa04979Cholesterol metabolism1.37E-023P38571, P61916, P45880LIPA, NPC2, VDAC2More
Imiquimodhsa05010Alzheimer disease3.56E-1121P49768, Q92542, O15239, O95298, P19404, P05496, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, Q12933, P18848, O15169, P67870, P31751, P05141, P28070, P43686PSEN1, NCSTN, NDUFA1, NDUFC2, NDUFV2, ATP5G1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, TRAF2, ATF4, AXIN1, CSNK2B, AKT2, SLC25A5, PSMB4, PSMC4More
Imiquimodhsa05012Parkinson disease1.79E-0619O15239, O95298, P13073, P12074, P05496, P05141, P12236, P60604, O75460, P18848, P28070, P43686, P19174, P0DP23, P0DP24, Q13557, Q71U36, Q13509, P68371NDUFA1, NDUFC2, COX4I1, COX6A1, ATP5G1, SLC25A5, SLC25A6, UBE2G2, ERN1, ATF4, PSMB4, PSMC4, PLCG1, CALM1, CALM2, CAMK2D, TUBA1A, TUBB3, TUBB2CMore
Imiquimodhsa05014Amyotrophic lateral sclerosis4.18E-025P19404, P12074, O75460, P28070, Q8TEV9NDUFV2, COX6A1, ERN1, PSMB4, SMCR8More
Imiquimodhsa05016Huntington disease5.66E-1017O15239, O95298, P19404, P13073, P12074, P05496, Q9GZM3, P24928, P30876, P62487, P52435, P05141, P45880, Q9NYC9, O75460, P28070, O00232NDUFA1, NDUFC2, NDUFV2, COX4I1, COX6A1, ATP5G1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, VDAC2, DNAH9, ERN1, PSMB4, PSMD12More
Imiquimodhsa05017Spinocerebellar ataxia1.88E-049Q92915, O75460, Q8TB72, O15399, P42338, P31751, P28070, P05141, P21796FGF14, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1More
Imiquimodhsa05020Prion disease1.85E-0616P01584, P46531, P0DMV8, P11142, O15239, O95298, P05496, P13073, P12074, P18848, P05141, P12236, P28070, P43686, P67870, Q99941IL1B, NOTCH1, HSPA1A, HSPA8, NDUFA1, NDUFC2, ATP5G1, COX4I1, COX6A1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, CSNK2B, CREBL1More
Imiquimodhsa05022Pathways of neurodegeneration - multiple diseases8.92E-1131P67870, O15239, Q16718, O95298, P19404, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, Q12933, Q13561, P48058, P05141, P45880, P17252, Q15078, Q00535, O15169, P01584, P49768, Q08752, O15020, P0DP24, P0DP23, Q13557, P62987, P28070, P43686CSNK2B, NDUFA1, NDUFA5, NDUFC2, NDUFV2, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, TRAF2, DCTN2, GRIA4, SLC25A5, VDAC2, PRKCA, CDK5R1, CDK5, AXIN1, IL1B, PSEN1, PPID, SPTBN2, CALM2, CALM1, CAMK2D, UBA52, PSMB4, PSMC4More
Imiquimodhsa05030Cocaine addiction5.99E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Imiquimodhsa05031Amphetamine addiction2.45E-068P48058, P0DP24, P0DP23, Q13557, P22694, Q99941, P18848, P17252GRIA4, CALM2, CALM1, CAMK2D, PRKACB, CREBL1, ATF4, PRKCAMore
Imiquimodhsa05032Morphine addiction4.54E-058P62873, P63218, P50151, Q13370, Q07343, P78334, P32298, P43250GNB1, GNG5, GNG10, PDE3B, PDE4B, GABRE, GRK4, GRK6More
Imiquimodhsa05033Nicotine addiction4.01E-021P78334GABREMore
Imiquimodhsa05034Alcoholism4.64E-0512Q99941, P18848, Q13547, P0DP24, P62873, P62879, P61952, P04049, P0C0S5, Q9BTM1, P62807, Q16778CREBL1, ATF4, HDAC1, CALM2, GNB1, GNB2, GNG11, RAF1, H2AFZ, H2AFJ, HIST1H2BC, HIST2H2BEMore
Imiquimodhsa05100Bacterial invasion of epithelial cells2.23E-044Q14141, Q05397, Q92529, Q96JJ3SEPT6, PTK2, SHC3, ELMO2More
Imiquimodhsa05110Vibrio cholerae infection2.47E-044Q99437, P17252, P17612, P22694ATP6V0B, PRKCA, PRKACA, PRKACBMore
Imiquimodhsa05120Epithelial cell signaling in Helicobacter pylori infection1.33E-1213Q16539, P25963, Q13488, Q99437, Q13153, P09341, P19875, P10145, P19174, P25024, P25025, P41240, P07948MAPK14, NFKBIA, TCIRG1, ATP6V0B, PAK1, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2, CSK, LYNMore
Imiquimodhsa05130Pathogenic Escherichia coli infection3.26E-0412Q71U36, P16333, Q13509, P68371, P60709, Q14344, P25963, P04406, P29350, Q15438, P35579, P55061TUBA1A, NCK1, TUBB3, TUBB2C, ACTB, GNA13, NFKBIA, GAPDH, PTPN6, PSCD1, MYH9, TEGTMore
Imiquimodhsa05131Shigellosis2.79E-0514Q12933, Q13546, Q05655, Q02156, Q9UDY8, Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q12778, Q13315, P10415, P07737TRAF2, RIPK1, PRKCD, PRKCE, MALT1, RRAGD, UBB, SEPT6, ELMO2, PTK2, FOXO1, ATM, BCL2, PFN1More
Imiquimodhsa05132Salmonella infection3.22E-0920P51617, P25963, P08238, P04049, Q9UJU2, P01106, P84095, P60709, Q13546, Q13489, P10415, P04406, O75369, P07737, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754IRAK1, NFKBIA, HSP90AB1, RAF1, LEF1, MYC, RHOG, ACTB, RIPK1, BIRC3, BCL2, GAPDH, FLNB, PFN1, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41More
Imiquimodhsa05133Pertussis1.43E-053P05107, P10145, P0C0L4ITGB2, IL8, C4AMore
Imiquimodhsa05134Legionellosis3.53E-099P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Imiquimodhsa05135Yersinia infection1.86E-048Q05397, P51812, P06239, P19174, Q02750, P42338, Q96JJ3, P01732PTK2, RPS6KA3, LCK, PLCG1, MAP2K1, PIK3CB, ELMO2, CD8AMore
Imiquimodhsa05140Leishmaniasis3.81E-0813P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Imiquimodhsa05142Chagas disease2.70E-022P48023, Q14790FASLG, CASP8More
Imiquimodhsa05143African trypanosomiasis2.11E-032P69905, P68871HBA2, HBBMore
Imiquimodhsa05144Malaria5.55E-069P60033, P69905, P68871, O60603, P01375, P05107, P35443, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL8, KLRK1More
Imiquimodhsa05146Amoebiasis5.20E-1712P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Imiquimodhsa05150Staphylococcus aureus infection5.41E-0815P09871, P0C0L4, P21730, P21462, O75015, P31995, P13765, P13646, Q14532, P05107, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, FCGR2C, HLA-DOB, KRT13, KRT32, ITGB2, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Imiquimodhsa05152Tuberculosis1.04E-047P04049, P0DP23, P48382, P31751, P10415, Q9UDY8, P51617RAF1, CALM1, RFX5, AKT2, BCL2, MALT1, IRAK1More
Imiquimodhsa05160Hepatitis C2.32E-033Q13546, P01568, P04049RIPK1, IFNA21, RAF1More
Imiquimodhsa05161Hepatitis B4.32E-034P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Imiquimodhsa05162Measles5.20E-046P23458, P31751, P0DMV8, P01584, P67870, Q9NP90JAK1, AKT2, HSPA1A, IL1B, CSNK2B, RAB9BMore
Imiquimodhsa05163Human cytomegalovirus infection2.12E-1430P31751, P04049, P01375, P25963, P62873, P63218, P50151, P61952, Q14643, P0DP23, P0DP24, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P30101, P61769, P01568AKT2, RAF1, TNF, NFKBIA, GNB1, GNG5, GNG10, GNG11, ITPR1, CALM1, CALM2, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, PDIA3, B2M, IFNA21More
Imiquimodhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Imiquimodhsa05165Human papillomavirus infection2.80E-0410P02452, P24821, Q16363, P30281, Q9UM47, P01568, P01889, P10321, Q99437, P04628COL1A1, TNC, LAMA4, CCND3, NOTCH3, IFNA21, HLA-B, HLA-C, ATP6V0B, WNT1More
Imiquimodhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Imiquimodhsa05167Kaposi sarcoma-associated herpesvirus infection1.42E-0713P01568, P31751, P42224, P25963, P62873, P63218, P50151, P19174, P04049, P07948, P01106, P04141, P0DP23IFNA21, AKT2, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, RAF1, LYN, MYC, CSF2, CALM1More
Imiquimodhsa05168Herpes simplex virus 1 infection5.93E-0422O00463, O60603, P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q16629, P30101, Q9Y2A4, Q13398, P51522, Q9NR11, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415TRAF5, TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, SFRS7, PDIA3, ZNF443, ZNF211, ZNF83, ZNF302, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Imiquimodhsa05169Epstein-Barr virus infection1.72E-0617P13765, P01106, Q13547, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, P42224, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, STAT1, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Imiquimodhsa05170Human immunodeficiency virus 1 infection1.28E-0718P31751, P04049, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P51617, P25963, Q13315, P19174, P10415, Q9Y6Q5AKT2, RAF1, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, IRAK1, NFKBIA, ATM, PLCG1, BCL2, AP1M2More
Imiquimodhsa05171Coronavirus disease - COVID-193.96E-0917P23396, P62753, P25398, P42677, P36578, Q02878, P62917, P32969, P27635, P26373, Q07020, P46776, P62899, P62910, P18077, P61927, P05386RPS3, RPS6, RPS12, RPS27, RPL4, RPL6, RPL8, RPL9, RPL10, RPL13, RPL18, RPL27A, RPL31, RPL32, RPL35A, RPL37, RPLP1More
Imiquimodhsa05200Pathways in cancer2.72E-0930P17301, P08238, P42224, P25963, P19174, P01106, Q9UJU2, P43246, P84022, Q13485, P20585, P52701, P14923, P30279, P10415, Q13077, P14921, P31751, P62873, P62879, P63218, P50151, Q14344, Q9UM47, P78417, O75293, P0DP23, P01568, P14784, P01042ITGA2, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, LEF1, MSH2, SMAD3, SMAD4, MSH3, MSH6, JUP, CCND2, BCL2, TRAF1, ETS1, AKT2, GNB1, GNB2, GNG5, GNG10, GNA13, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1More
Imiquimodhsa05202Transcriptional misregulation in cancer4.01E-0919Q12778, Q15532, Q13315, P41732, P14780, P27930, Q15744, Q16548, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Imiquimodhsa05203Viral carcinogenesis6.92E-0616Q12933, Q99941, P18848, P23458, P30281, P27348, Q7KZF4, Q13547, P06396, P12814, P01889, P10321, P61978, P06493, P62807, Q16778TRAF2, CREBL1, ATF4, JAK1, CCND3, YWHAQ, SND1, HDAC1, GSN, ACTN1, HLA-B, HLA-C, HNRPK, CDK1, HIST1H2BC, HIST2H2BEMore
Imiquimodhsa05205Proteoglycans in cancer6.79E-0510Q13009, Q12955, O75369, P60709, P04049, P01106, P08069, P19174, P29350, P08962TIAM1, ANK3, FLNB, ACTB, RAF1, MYC, IGF1R, PLCG1, PTPN6, CD63More
Imiquimodhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Imiquimodhsa05210Colorectal cancer1.47E-049Q9UKG1, Q13485, P43246, P04049, P01106, P52701, P20585, P37173, O75293APPL1, SMAD4, MSH2, RAF1, MYC, MSH6, MSH3, TGFBR2, GADD45BMore
Imiquimodhsa05211Renal cell carcinoma5.09E-053Q13153, P31751, P04049PAK1, AKT2, RAF1More
Imiquimodhsa05212Pancreatic cancer2.41E-058P31751, P04049, Q15311, P23458, P42224, P37173, P84022, O75293AKT2, RAF1, RALBP1, JAK1, STAT1, TGFBR2, SMAD3, GADD45BMore
Imiquimodhsa05213Endometrial cancer5.61E-053Q13418, P31751, P04049ILK, AKT2, RAF1More
Imiquimodhsa05214Glioma2.19E-066P08069, P0DP23, P04049, P31751, P19174, O75293IGF1R, CALM1, RAF1, AKT2, PLCG1, GADD45BMore
Imiquimodhsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Imiquimodhsa05217Basal cell carcinoma4.31E-022P04628, Q9UJU2WNT1, LEF1More
Imiquimodhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Imiquimodhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Imiquimodhsa05220Chronic myeloid leukemia9.63E-042P31751, P04049AKT2, RAF1More
Imiquimodhsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Imiquimodhsa05222Small cell lung cancer4.78E-021P31751AKT2More
Imiquimodhsa05223Non-small cell lung cancer3.49E-042P31751, P04049AKT2, RAF1More
Imiquimodhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Imiquimodhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Imiquimodhsa05226Gastric cancer6.81E-042P04049, P31751RAF1, AKT2More
Imiquimodhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Imiquimodhsa05231Choline metabolism in cancer1.89E-079P04049, P31751, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494RAF1, AKT2, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1More
Imiquimodhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.46E-1417P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Imiquimodhsa05310Asthma7.64E-083P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Imiquimodhsa05321Inflammatory bowel disease6.51E-157O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Imiquimodhsa05322Systemic lupus erythematosus3.82E-0511P08637, O75015, P08246, P08311, P01375, P10747, P13765, P62807, Q16778, P14678, P12814FCGR3A, FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, HIST1H2BC, HIST2H2BE, SNRPB, ACTN1More
Imiquimodhsa05323Rheumatoid arthritis1.89E-047P01375, Q06643, P13765, P10747, P09341, P19875, O60603TNF, LTB, HLA-DOB, CD28, CXCL1, CXCL2, TLR2More
Imiquimodhsa05330Allograft rejection2.83E-023P13765, P10747, P01375HLA-DOB, CD28, TNFMore
Imiquimodhsa05332Graft-versus-host disease7.36E-135P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Imiquimodhsa05340Primary immunodeficiency2.96E-046P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Imiquimodhsa05410Hypertrophic cardiomyopathy3.63E-022P26012, P09493ITGB8, TPM1More
Imiquimodhsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Imiquimodhsa05414Dilated cardiomyopathy3.78E-034P54284, P26012, P09493, P26678CACNB3, ITGB8, TPM1, PLNMore
Imiquimodhsa05415Diabetic cardiomyopathy3.30E-049P17252, P30405, P14598, Q15080, Q16718, O14521, Q16539, P14780, P37173PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, MAPK14, MMP9, TGFBR2More
Imiquimodhsa05418Fluid shear stress and atherosclerosis3.43E-0610Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Imiquimod (SDC: 10.98)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P43250GRK6G proteinNonecoupled receptor kinase 6Predicted10.15470.09550.29480.5632
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P63279UBE2ISUMONoneconjugating enzyme UBC9Predicted00.23320.05120.49830.7173
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1APredicted10.4320.269500.7551
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
P00374DHFRDihydrofolate reductasePredicted00.3380.18680.22630.7688
P04818TYMSThymidylate synthasePredicted10.45530.27060.18930.9582
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
Q9Y6R4MAP3K4MitogenNoneactivated protein kinase kinase kinase 4Predicted00.35280.24520.1730.8399
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
Q15831STK11Serine/threonineNoneprotein kinase STK11Predicted00.15110.24410.45491.0186
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
Q8IVW4CDKL3CyclinNonedependent kinaseNonelike 3Predicted00.41490.241600.6906
Q13873BMPR2Bone morphogenetic protein receptor typeNone2Predicted10.34760.24520.35481.019
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
O75460ERN1Serine/threonineNoneprotein kinase/endoribonuclease IRE1Predicted10.68060.29440.5571.4862
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
Q16566CAMK4Calcium/calmodulinNonedependent protein kinase type IVPredicted00.07180.24410.61761.1417
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
P07332FESTyrosineNoneprotein kinase Fes/FpsPredicted00.27220.26280.15130.8131
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
Q99759MAP3K3MitogenNoneactivated protein kinase kinase kinase 3Predicted00.35450.24520.43781.1055
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P45985MAP2K4Dual specificity mitogenNoneactivated protein kinase kinase 4Predicted00.42480.24730.74031.4474
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
Q9Y6E0STK24Serine/threonineNoneprotein kinase 24Predicted00.54580.245200.7634
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
Q8IVH8MAP4K3MitogenNoneactivated protein kinase kinase kinase kinase 3Predicted00.38330.26730.14870.875
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
Q13523PRPF4BSerine/threonineNoneprotein kinase PRP4 homologPredicted00.13760.245200.5593
P49760CLK2Dual specificity protein kinase CLK2Predicted00.03030.295100.6053
Q9H2K8TAOK3Serine/threonineNoneprotein kinase TAO3Predicted00.06460.24520.14870.6715
Q9P289STK26Serine/threonineNoneprotein kinase 26Predicted10.02850.262800.5399
Q9NQU5PAK6Serine/threonineNoneprotein kinase PAK 6Predicted00.4090.26690.50031.2386
Q8NI60CABC1Atypical kinase COQ8A, mitochondrialPredicted00.62760.245200.8043
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
O95747OXSR1Serine/threonineNoneprotein kinase OSR1Predicted00.18390.245200.5825
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
O14976GAKCyclinNoneGNoneassociated kinasePredicted10.57280.256200.7989
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
O95835LATS1Serine/threonineNoneprotein kinase LATS1Predicted00.43320.24520.02170.7288
O43283MAP3K13MitogenNoneactivated protein kinase kinase kinase 13Predicted00.45650.24520.14870.8674
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
Q9H422HIPK3HomeodomainNoneinteracting protein kinase 3Predicted00.3650.25080.2180.902
O94806PRKD3Serine/threonineNoneprotein kinase D3Predicted00.23120.24340.16920.7715
Q00536PCTK1CyclinNonedependent kinase 16Predicted00.27140.25600.6478
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
Q16513PKN2Serine/threonineNoneprotein kinase N2Predicted00.04210.27780.33910.9157
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q9UEW8STK39STE20/SPS1Nonerelated prolineNonealanineNonerich protein kinasePredicted00.25730.245200.6191
Q96BR1SGK3Serine/threonineNoneprotein kinase Sgk3Predicted00.0260.26840.31140.8612
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
Q86Z02HIPK1HomeodomainNoneinteracting protein kinase 1Predicted00.46310.28160.2181.0128
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P32298GRK4G proteinNonecoupled receptor kinase 4Predicted00.03520.23860.29480.7896
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P04406GAPDHGlyceraldehydeNone3Nonephosphate dehydrogenasePredicted00.45350.12230.46660.938
P16389KCNA2Potassium voltageNonegated channel subfamily A member 2Predicted00.01310.083500.1736
P17658KCNA6Potassium voltageNonegated channel subfamily A member 6Predicted00.28270.078500.2984
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
Q01726MC1RMelanocyteNonestimulating hormone receptorPredicted10.0470.23750.0110.5095
P41968MC3RMelanocortin receptor 3Predicted10.22350.263700.6392
P35557GCKHexokinaseNone4Predicted00.00490.05580.32420.4382
Q13418ILKIntegrinNonelinked protein kinasePredicted00.58850.03880.3940.7658
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)