PharmaCoNets

PharmaCoNets of Imipramine (S_PCN: 185.55 )

Imipramine regulated-network (S_DN: 24.91)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Imipramine

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Imipramine

hsa00040

Pentose and glucuronate interconversions

4.00E-02

P15121

AKR1B1

Imipramine

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Imipramine

hsa00053

Ascorbate and aldarate metabolism

3.63E-04

P51648, P14550, Q9UEF7

ALDH3A2, AKR1A1, KL

Imipramine

hsa00061

Fatty acid biosynthesis

4.83E-02

P33121

ACSL1

Imipramine

hsa00190

Oxidative phosphorylation

4.07E-05

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Imipramine

hsa00220

Arginine biosynthesis

1.97E-02

P15104, P49448

GLUL, GLUD2

Imipramine

hsa00240

Pyrimidine metabolism

4.29E-02

P21589, P04183

NT5E, TK1

Imipramine

hsa00250

Alanine, aspartate and glutamate metabolism

1.97E-02

P49448, P15104

GLUD2, GLUL

Imipramine

hsa00280

Valine, leucine and isoleucine degradation

4.55E-02

P21953, P51648

BCKDHB, ALDH3A2

Imipramine

hsa00500

Starch and sucrose metabolism

1.67E-02

O43451, P06737

MGAM, PYGL

Imipramine

hsa00513

Various types of N-glycan biosynthesis

4.96E-02

Q9NR34

MAN1C1

Imipramine

hsa00564

Glycerophospholipid metabolism

4.29E-02

Q6P1A2, P23743

MBOAT5, DGKA

Imipramine

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Imipramine

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Imipramine

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Imipramine

hsa00600

Sphingolipid metabolism

3.01E-02

Q9BX95, P06280

SGPP1, GLA

Imipramine

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.87E-03

P06865, O15466, Q9H4F1

HEXA, ST8SIA5, ST6GALNAC4

Imipramine

hsa00620

Pyruvate metabolism

3.17E-03

P40926, P07195, P14550, P11766

MDH2, LDHB, AKR1A1, ADH5

Imipramine

hsa00730

Thiamine metabolism

5.29E-03

P05186, P24666

ALPL, ACP1

Imipramine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Imipramine

hsa00790

Folate biosynthesis

2.02E-02

P15121

AKR1B1

Imipramine

hsa00830

Retinol metabolism

3.15E-02

P00325

ADH1B

Imipramine

hsa00910

Nitrogen metabolism

1.97E-02

P15104, P49448

GLUL, GLUD2

Imipramine

hsa00970

Aminoacyl-tRNA biosynthesis

3.49E-04

O95363, P14868, Q15046

FARS2, DARS, KARS

Imipramine

hsa00980

Metabolism of xenobiotics by cytochrome P450

6.38E-04

P78417, P09211, P11712

GSTO1, GSTP1, CYP2C9

Imipramine

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Imipramine

hsa00983

Drug metabolism - other enzymes

1.70E-04

P04183, P32320, P05164

TK1, CDA, MPO

Imipramine

hsa01100

Metabolic pathways

4.56E-02

P15144, P32320, P06280, P24666, P33121, P42330, Q13093, Q9NY28, Q9BX95, P09960, Q16718

ANPEP, CDA, GLA, ACP1, ACSL1, AKR1C3, PLA2G7, GALNT8, SGPP1, LTA4H, NDUFA5

Imipramine

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Imipramine

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Imipramine

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Imipramine

hsa01521

EGFR tyrosine kinase inhibitor resistance

3.18E-04

P04049, P08069

RAF1, IGF1R

Imipramine

hsa01522

Endocrine resistance

2.63E-05

P14780, P22694, P04049, Q9UM47, P08069, P10415, Q13323

MMP9, PRKACB, RAF1, NOTCH3, IGF1R, BCL2, BIK

Imipramine

hsa01523

Antifolate resistance

3.80E-02

Q92820, P04818

GGH, TYMS

Imipramine

hsa02010

ABC transporters

1.66E-04

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Imipramine

hsa03010

Ribosome

3.40E-09

P62753, P42677, P25398, P32969, P40429, P62917, P62829, P46776, Q9H0U6, Q07020, P62910, P18077, Q02878, P36578, P27635, P05386, P62249, P23396

RPS6, RPS27, RPS12, RPL9, RPL13A, RPL8, RPL23, RPL27A, MRPL18, RPL18, RPL32, RPL35A, RPL6, RPL4, RPL10, RPLP1, RPS16, RPS3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	P62753	RPS6	40S ribosomal protein S6	0.769
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P62753	RPS6	40S ribosomal protein S6	0.739
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P42677	RPS27	40S ribosomal protein S27	0.834
P02768	ALB	Albumin	P25398	RPS12	40S ribosomal protein S12	0.775
P02768	ALB	Albumin	P32969	RPL9	60S ribosomal protein L9	0.795
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P32969	RPL9	60S ribosomal protein L9	0.722
P09211	GSTP1	Glutathione S-transferase P	P40429	RPL13A	60S ribosomal protein L13a	0.741
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P40429	RPL13A	60S ribosomal protein L13a	0.825
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P62917	RPL8	60S ribosomal protein L8	0.866
P02768	ALB	Albumin	P62829	RPL23	60S ribosomal protein L23	0.757
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P46776	RPL27A	60S ribosomal protein L27a	0.758
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	Q9H0U6	MRPL18	39S ribosomal protein L18, mitochondrial	0.831
P09211	GSTP1	Glutathione S-transferase P	Q07020	RPL18	60S ribosomal protein L18	0.779
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	Q07020	RPL18	60S ribosomal protein L18	0.802
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P62910	RPL32	60S ribosomal protein L32	0.804
P02768	ALB	Albumin	P18077	RPL35A	60S ribosomal protein L35a	0.7
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	Q02878	RPL6	60S ribosomal protein L6	0.819
P02768	ALB	Albumin	P36578	RPL4	60S ribosomal protein L4	0.708
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P36578	RPL4	60S ribosomal protein L4	0.823
P09211	GSTP1	Glutathione S-transferase P	P27635	RPL10	60S ribosomal protein L10	0.772
P09211	GSTP1	Glutathione S-transferase P	P05386	RPLP1	60S acidic ribosomal protein P1	0.707
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P05386	RPLP1	60S acidic ribosomal protein P1	0.881
P09211	GSTP1	Glutathione S-transferase P	P62249	RPS16	40S ribosomal protein S16	0.702
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P62249	RPS16	40S ribosomal protein S16	0.818
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P23396	RPS3	40S ribosomal protein S3	0.886
P02768	ALB	Albumin	P62753	RPS6	40S ribosomal protein S6	0.769
P02768	ALB	Albumin	P25398	RPS12	40S ribosomal protein S12	0.775
P02768	ALB	Albumin	P32969	RPL9	60S ribosomal protein L9	0.795
P09211	GSTP1	Glutathione S-transferase P	P40429	RPL13A	60S ribosomal protein L13a	0.741
P02768	ALB	Albumin	P62829	RPL23	60S ribosomal protein L23	0.757
P09211	GSTP1	Glutathione S-transferase P	Q07020	RPL18	60S ribosomal protein L18	0.779
P02768	ALB	Albumin	P18077	RPL35A	60S ribosomal protein L35a	0.7
P02768	ALB	Albumin	P36578	RPL4	60S ribosomal protein L4	0.708
P09211	GSTP1	Glutathione S-transferase P	P27635	RPL10	60S ribosomal protein L10	0.772
P09211	GSTP1	Glutathione S-transferase P	P05386	RPLP1	60S acidic ribosomal protein P1	0.707
P09211	GSTP1	Glutathione S-transferase P	P62249	RPS16	40S ribosomal protein S16	0.702

Imipramine

hsa03013

RNA transport

3.98E-02

P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22748	CA4	Carbonic anhydrase 4	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.879
P22748	CA4	Carbonic anhydrase 4	O14893	GEMIN2	Gem-associated protein 2	-0.709
P22748	CA4	Carbonic anhydrase 4	P61326	MAGOH	Protein mago nashi homolog	-0.822
P22748	CA4	Carbonic anhydrase 4	Q7Z3B4	NUP54	Nucleoporin p54	-0.776
P22748	CA4	Carbonic anhydrase 4	P35658	NUP214	Nuclear pore complex protein Nup214	0.827
P22748	CA4	Carbonic anhydrase 4	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.786
P22748	CA4	Carbonic anhydrase 4	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.869
P22748	CA4	Carbonic anhydrase 4	P78345	RPP38	Ribonuclease P protein subunit p38	-0.731
P22748	CA4	Carbonic anhydrase 4	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.912
P08246	ELA2	Neutrophil elastase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.852
P22748	CA4	Carbonic anhydrase 4	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.879
P08246	ELA2	Neutrophil elastase	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.732
P08246	ELA2	Neutrophil elastase	O14893	GEMIN2	Gem-associated protein 2	-0.785
P22748	CA4	Carbonic anhydrase 4	O14893	GEMIN2	Gem-associated protein 2	-0.709
P22748	CA4	Carbonic anhydrase 4	P61326	MAGOH	Protein mago nashi homolog	-0.822
P08246	ELA2	Neutrophil elastase	Q7Z3B4	NUP54	Nucleoporin p54	-0.723
P22748	CA4	Carbonic anhydrase 4	Q7Z3B4	NUP54	Nucleoporin p54	-0.776
P08246	ELA2	Neutrophil elastase	P35658	NUP214	Nuclear pore complex protein Nup214	0.765
P22748	CA4	Carbonic anhydrase 4	P35658	NUP214	Nuclear pore complex protein Nup214	0.827
P08246	ELA2	Neutrophil elastase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.722
P22748	CA4	Carbonic anhydrase 4	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.786
P08246	ELA2	Neutrophil elastase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.825
P22748	CA4	Carbonic anhydrase 4	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.869
P08246	ELA2	Neutrophil elastase	P78345	RPP38	Ribonuclease P protein subunit p38	-0.795
P22748	CA4	Carbonic anhydrase 4	P78345	RPP38	Ribonuclease P protein subunit p38	-0.731
P08246	ELA2	Neutrophil elastase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.849
P22748	CA4	Carbonic anhydrase 4	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.912

Imipramine

hsa03020

RNA polymerase

2.72E-08

P30876, P24928, P62487, Q9GZM3, P52435

POLR2B, POLR2A, POLR2G, POLR2J2, POLR2J

Imipramine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Imipramine

hsa03050

Proteasome

1.21E-02

P28074

PSMB5

Imipramine

hsa03060

Protein export

4.46E-03

Q15070, O76094

OXA1L, SRP72

Imipramine

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Imipramine

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Imipramine

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Imipramine

hsa04010

MAPK signaling pathway

1.69E-03

P04049, P08069

RAF1, IGF1R

Imipramine

hsa04012

ErbB signaling pathway

1.82E-02

P04049

RAF1

Imipramine

hsa04014

Ras signaling pathway

1.30E-03

P04049, P08069

RAF1, IGF1R

Imipramine

hsa04015

Rap1 signaling pathway

1.25E-03

P04049, P08069, P25116, Q8TEU7, P08514, P17252

RAF1, IGF1R, F2R, RAPGEF6, ITGA2B, PRKCA

Imipramine

hsa04022

cGMP-PKG signaling pathway

6.45E-03

P04049, P18848, Q8WYR1, P05141, P0DP24

RAF1, ATF4, PIK3R5, SLC25A5, CALM2

Imipramine

hsa04024

cAMP signaling pathway

2.66E-03

P49019, P22694, P20020, P04049, P48058

HCAR3, PRKACB, ATP2B1, RAF1, GRIA4

Imipramine

hsa04062

Chemokine signaling pathway

3.98E-02

P04049

RAF1

Imipramine

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Imipramine

hsa04068

FoxO signaling pathway

3.80E-04

P04049, P08069

RAF1, IGF1R

Imipramine

hsa04071

Sphingolipid signaling pathway

2.69E-07

P04049, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2

RAF1, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.935
P22748	CA4	Carbonic anhydrase 4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.814
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.935
P19652	ORM2	Alpha-1-acid glycoprotein 2	P01375	TNF	Tumor necrosis factor	0.871
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P02763	ORM1	Alpha-1-acid glycoprotein 1	P01375	TNF	Tumor necrosis factor	0.871
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.838
P22748	CA4	Carbonic anhydrase 4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.758
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.838
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.727
P22748	CA4	Carbonic anhydrase 4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.88
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.727
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P19652	ORM2	Alpha-1-acid glycoprotein 2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P22748	CA4	Carbonic anhydrase 4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.863
P02763	ORM1	Alpha-1-acid glycoprotein 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P08246	ELA2	Neutrophil elastase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.725
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P08246	ELA2	Neutrophil elastase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.797
P22748	CA4	Carbonic anhydrase 4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.814
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P08246	ELA2	Neutrophil elastase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.865
P22748	CA4	Carbonic anhydrase 4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.758
P08246	ELA2	Neutrophil elastase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.847
P22748	CA4	Carbonic anhydrase 4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.88
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P22748	CA4	Carbonic anhydrase 4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.863
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866

Imipramine

hsa04072

Phospholipase D signaling pathway

2.82E-02

P04049

RAF1

Imipramine

hsa04080

Neuroactive ligand-receptor interaction

2.95E-04

P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, P07550

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P08311	CTSG	Cathepsin G	-0.71
P07550	ADRB2	Beta-2 adrenergic receptor	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	-0.77
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.832
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	1
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.726
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	O00398	P2RY10	Putative P2Y purinoceptor 10	0.768
P07550	ADRB2	Beta-2 adrenergic receptor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.717
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P07550	ADRB2	Beta-2 adrenergic receptor	0.704
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P07550	ADRB2	Beta-2 adrenergic receptor	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	-0.77
P08246	ELA2	Neutrophil elastase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.846
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P08246	ELA2	Neutrophil elastase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.725
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P08246	ELA2	Neutrophil elastase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.797
P08246	ELA2	Neutrophil elastase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.793
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P07550	ADRB2	Beta-2 adrenergic receptor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.717
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1

Imipramine

hsa04110

Cell cycle

6.80E-03

P06493, O75293, P30304, P33981, P42773, P01106

CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC

Imipramine

hsa04114

Oocyte meiosis

1.43E-03

Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1R

Imipramine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Imipramine

hsa04137

Mitophagy - animal

3.55E-04

Q96CV9, Q9H1Y0, P18848, O43524

OPTN, ATG5, ATF4, FOXO3

Imipramine

hsa04140

Autophagy - animal

9.64E-03

P08069, P04049, P22694, Q14643, P10415

IGF1R, RAF1, PRKACB, ITPR1, BCL2

Imipramine

hsa04141

Protein processing in endoplasmic reticulum

1.39E-03

P18848, P30101, P49257, O60337, P60604, P11142, P07900, Q9H173

ATF4, PDIA3, LMAN1, MARH6, UBE2G2, HSPA8, HSP90AA1, SIL1

Imipramine

hsa04145

Phagosome

2.75E-02

Q15080, P14598, P68371, Q13488

NCF4, NCF1, TUBB2C, TCIRG1

Imipramine

hsa04146

Peroxisome

3.03E-04

O43933, O96011, P56589, Q9UKG9, O75521, P33121

PEX1, PEX11B, PEX3, CROT, ECI2, ACSL1

Imipramine

hsa04150

mTOR signaling pathway

5.20E-04

P08069, P04049

IGF1R, RAF1

Imipramine

hsa04151

PI3K-Akt signaling pathway

1.24E-03

P62753, P43657, O43521, P27348, P09603, Q9GZP0, Q8WYR1, P63218, P50151, P13612, O15335, Q13751, P18848, O00141, Q6ZUJ8

RPS6, P2RY5, BCL2L11, YWHAQ, CSF1, PDGFD, PIK3R5, GNG5, GNG10, ITGA4, CHAD, LAMB3, ATF4, SGK, PIK3AP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P61073	CXCR4	C-X-C chemokine receptor type 4	P62753	RPS6	40S ribosomal protein S6	0.709
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P61073	CXCR4	C-X-C chemokine receptor type 4	P27348	YWHAQ	14-3-3 protein theta	0.708
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.789
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.736
P61073	CXCR4	C-X-C chemokine receptor type 4	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.76
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.844
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.902
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P13612	ITGA4	Integrin alpha-4	0.77
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	O15335	CHAD	Chondroadherin	-0.729
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q13751	LAMB3	Laminin subunit beta-3	-0.794
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P61073	CXCR4	C-X-C chemokine receptor type 4	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.755
P61073	CXCR4	C-X-C chemokine receptor type 4	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.728
P61073	CXCR4	C-X-C chemokine receptor type 4	P62753	RPS6	40S ribosomal protein S6	0.709
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P61073	CXCR4	C-X-C chemokine receptor type 4	P27348	YWHAQ	14-3-3 protein theta	0.708
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.789
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.736
P61073	CXCR4	C-X-C chemokine receptor type 4	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.76
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.844
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.902
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P13612	ITGA4	Integrin alpha-4	0.77
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	O15335	CHAD	Chondroadherin	-0.729
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q13751	LAMB3	Laminin subunit beta-3	-0.794
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P61073	CXCR4	C-X-C chemokine receptor type 4	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.755
P61073	CXCR4	C-X-C chemokine receptor type 4	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.728

Imipramine

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Imipramine

hsa04210

Apoptosis

6.94E-04

O76075, P01375, Q9NR28, O75460, Q16548, O43521, P18848, P04049

DFFB, TNF, DIABLO, ERN1, BCL2A1, BCL2L11, ATF4, RAF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1

Imipramine

hsa04211

Longevity regulating pathway

2.16E-02

P08069

IGF1R

Imipramine

hsa04213

Longevity regulating pathway - multiple species

2.83E-03

P08069, Q9Y4H2, Q13547

IGF1R, IRS2, HDAC1

Imipramine

hsa04217

Necroptosis

9.04E-10

P01375, P01568, P48023, Q13489, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q13557, Q9H444, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CAMK2D, CHMP4B, CHMP2A, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	P01568	IFNA21	Interferon alpha-21	0.838
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.785
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.799
P61073	CXCR4	C-X-C chemokine receptor type 4	P15104	GLUL	Glutamine synthetase	0.754
P02768	ALB	Albumin	P15104	GLUL	Glutamine synthetase	0.717
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P61073	CXCR4	C-X-C chemokine receptor type 4	P0C0S5	H2AFZ	Histone H2A.Z	0.732
P02768	ALB	Albumin	P0C0S5	H2AFZ	Histone H2A.Z	0.756
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P61073	CXCR4	C-X-C chemokine receptor type 4	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.731
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.702
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.817
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P61073	CXCR4	C-X-C chemokine receptor type 4	P15104	GLUL	Glutamine synthetase	0.754
P02768	ALB	Albumin	P15104	GLUL	Glutamine synthetase	0.717
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P61073	CXCR4	C-X-C chemokine receptor type 4	P0C0S5	H2AFZ	Histone H2A.Z	0.732
P02768	ALB	Albumin	P0C0S5	H2AFZ	Histone H2A.Z	0.756
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P61073	CXCR4	C-X-C chemokine receptor type 4	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.731

Imipramine

hsa04218

Cellular senescence

8.08E-03

P01106, P04049, O75293, P30304, P06493

MYC, RAF1, GADD45B, CDC25A, CDK1

Imipramine

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Imipramine

hsa04270

Vascular smooth muscle contraction

2.32E-02

P04049

RAF1

Imipramine

hsa04340

Hedgehog signaling pathway

7.27E-04

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Imipramine

hsa04360

Axon guidance

2.49E-02

P04049

RAF1

Imipramine

hsa04370

VEGF signaling pathway

2.77E-04

P16298, Q05397, Q02750, P04049

PPP3CB, PTK2, MAP2K1, RAF1

Imipramine

hsa04371

Apelin signaling pathway

2.65E-02

P04049

RAF1

Imipramine

hsa04510

Focal adhesion

1.18E-03

P04049, P08069

RAF1, IGF1R

Imipramine

hsa04512

ECM-receptor interaction

4.41E-02

Q13751, P13612, O15335

LAMB3, ITGA4, CHAD

Imipramine

hsa04520

Adherens junction

8.29E-03

P08069

IGF1R

Imipramine

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Imipramine

hsa04540

Gap junction

5.06E-03

P22694, P68371, P04049, Q14643

PRKACB, TUBB2C, RAF1, ITPR1

Imipramine

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.61E-03

Q13873, P04049, Q02750, P08069, Q86SE9

BMPR2, RAF1, MAP2K1, IGF1R, PCGF5

Imipramine

hsa04610

Complement and coagulation cascades

1.15E-08

P0C0L4

C4A

Imipramine

hsa04611

Platelet activation

3.39E-02

P25116, P08514, P07359

F2R, ITGA2B, GP1BA

Imipramine

hsa04612

Antigen processing and presentation

1.07E-03

Q14953, P26715, P26717, Q13241, P01732, P01375

KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Imipramine

hsa04613

Neutrophil extracellular trap formation

1.49E-11

P04049, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

RAF1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P19652	ORM2	Alpha-1-acid glycoprotein 2	O60603	TLR2	Toll-like receptor 2	0.783
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
P02763	ORM1	Alpha-1-acid glycoprotein 1	O60603	TLR2	Toll-like receptor 2	0.783
P19652	ORM2	Alpha-1-acid glycoprotein 2	P05164	MPO	Myeloperoxidase	0.897
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P02763	ORM1	Alpha-1-acid glycoprotein 1	P05164	MPO	Myeloperoxidase	0.897
P19652	ORM2	Alpha-1-acid glycoprotein 2	P08246	ELA2	Neutrophil elastase	0.934
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P02763	ORM1	Alpha-1-acid glycoprotein 1	P08246	ELA2	Neutrophil elastase	0.934
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.897
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.897
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.755
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.755
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q15080	NCF4	Neutrophil cytosol factor 4	0.839
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.839
P19652	ORM2	Alpha-1-acid glycoprotein 2	P20160	AZU1	Azurocidin	0.863
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
P02763	ORM1	Alpha-1-acid glycoprotein 1	P20160	AZU1	Azurocidin	0.863
P19652	ORM2	Alpha-1-acid glycoprotein 2	P08311	CTSG	Cathepsin G	0.826
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P02763	ORM1	Alpha-1-acid glycoprotein 1	P08311	CTSG	Cathepsin G	0.826
P19652	ORM2	Alpha-1-acid glycoprotein 2	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P02763	ORM1	Alpha-1-acid glycoprotein 1	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P19652	ORM2	Alpha-1-acid glycoprotein 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.753
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P02763	ORM1	Alpha-1-acid glycoprotein 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.753
P19652	ORM2	Alpha-1-acid glycoprotein 2	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.751
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
P02763	ORM1	Alpha-1-acid glycoprotein 1	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.751
P19652	ORM2	Alpha-1-acid glycoprotein 2	P21462	FPR1	fMet-Leu-Phe receptor	0.815
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
P02763	ORM1	Alpha-1-acid glycoprotein 1	P21462	FPR1	fMet-Leu-Phe receptor	0.815
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767

Imipramine

hsa04621

NOD-like receptor signaling pathway

2.77E-03

Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838

ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9H1Y0	ATG5	Autophagy protein 5	-0.75
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9H1Y0	ATG5	Autophagy protein 5	-0.75
P19652	ORM2	Alpha-1-acid glycoprotein 2	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.739
P02763	ORM1	Alpha-1-acid glycoprotein 1	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.739
P19652	ORM2	Alpha-1-acid glycoprotein 2	O00463	TRAF5	TNF receptor-associated factor 5	-0.796
P02763	ORM1	Alpha-1-acid glycoprotein 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.796
P19652	ORM2	Alpha-1-acid glycoprotein 2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P02763	ORM1	Alpha-1-acid glycoprotein 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q05823	RNASEL	2-5A-dependent ribonuclease	0.771
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q05823	RNASEL	2-5A-dependent ribonuclease	0.771
P19652	ORM2	Alpha-1-acid glycoprotein 2	P01375	TNF	Tumor necrosis factor	0.871
P02763	ORM1	Alpha-1-acid glycoprotein 1	P01375	TNF	Tumor necrosis factor	0.871
P19652	ORM2	Alpha-1-acid glycoprotein 2	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P02763	ORM1	Alpha-1-acid glycoprotein 1	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P19652	ORM2	Alpha-1-acid glycoprotein 2	P12838	DEFA4	Neutrophil defensin 4	0.815
P02763	ORM1	Alpha-1-acid glycoprotein 1	P12838	DEFA4	Neutrophil defensin 4	0.815
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	Q9H1Y0	ATG5	Autophagy protein 5	-0.759
P08246	ELA2	Neutrophil elastase	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.702
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.734
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709

Imipramine

hsa04623

Cytosolic DNA-sensing pathway

3.15E-02

P01568, P25963

IFNA21, NFKBIA

Imipramine

hsa04625

C-type lectin receptor signaling pathway

1.49E-02

P04049

RAF1

Imipramine

hsa04630

JAK-STAT signaling pathway

1.49E-02

P04049

RAF1

Imipramine

hsa04640

Hematopoietic cell lineage

3.69E-02

P21926, P07766, P01730, P09564

CD9, CD3E, CD4, CD7

Imipramine

hsa04650

Natural killer cell mediated cytotoxicity

4.89E-07

P16298, P50591, P01375, P17252, O60880, P20963, Q02750, P04049, Q13241, P26718, P26717, Q14953, P26715

PPP3CB, TNFSF10, TNF, PRKCA, SH2D1A, CD247, MAP2K1, RAF1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	P17252	PRKCA	Protein kinase C alpha type	-0.727
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.71
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.717
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.717
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Imipramine

hsa04657

IL-17 signaling pathway

5.66E-05

P07900, O00463, Q16539, P49841, P19875, P14780, Q9UJX4, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL2, MMP9, ANAPC5, LCN2, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P22748	CA4	Carbonic anhydrase 4	O00463	TRAF5	TNF receptor-associated factor 5	-0.826
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P22748	CA4	Carbonic anhydrase 4	Q9UJX4	ANAPC5	Anaphase-promoting complex subunit 5	-0.723
P22748	CA4	Carbonic anhydrase 4	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P07550	ADRB2	Beta-2 adrenergic receptor	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.757
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P22748	CA4	Carbonic anhydrase 4	O00463	TRAF5	TNF receptor-associated factor 5	-0.826
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P22748	CA4	Carbonic anhydrase 4	Q9UJX4	ANAPC5	Anaphase-promoting complex subunit 5	-0.723
P07550	ADRB2	Beta-2 adrenergic receptor	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.757
P22748	CA4	Carbonic anhydrase 4	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718

Imipramine

hsa04660

T cell receptor signaling pathway

1.66E-02

P04049

RAF1

Imipramine

hsa04662

B cell receptor signaling pathway

9.95E-03

P04049

RAF1

Imipramine

hsa04664

Fc epsilon RI signaling pathway

1.16E-02

P04049

RAF1

Imipramine

hsa04666

Fc gamma R-mediated phagocytosis

2.32E-02

P04049

RAF1

Imipramine

hsa04668

TNF signaling pathway

2.67E-03

P01375, P18848, P19875, P01584, P14780, P20333

TNF, ATF4, CXCL2, IL1B, MMP9, TNFRSF1B

Imipramine

hsa04672

Intestinal immune network for IgA production

1.35E-02

P29965, P13765

CD40LG, HLA-DOB

Imipramine

hsa04713

Circadian entrainment

1.69E-02

P17252, P48058, P22694

PRKCA, GRIA4, PRKACB

Imipramine

hsa04714

Thermogenesis

4.53E-04

P22694, Q16539, P33121, Q16718, O14521

PRKACB, MAPK14, ACSL1, NDUFA5, SDHD

Imipramine

hsa04720

Long-term potentiation

4.88E-03

P16298, P51812, Q02750, P04049

PPP3CB, RPS6KA3, MAP2K1, RAF1

Imipramine

hsa04721

Synaptic vesicle cycle

6.59E-04

Q13488, P31645

TCIRG1, SLC6A4

Imipramine

hsa04722

Neurotrophin signaling pathway

7.10E-03

P04049, P49841, O43524, P48023

RAF1, GSK3B, FOXO3, FASLG

Imipramine

hsa04723

Retrograde endocannabinoid signaling

1.20E-03

P17252, P48058, P22694, Q16718

PRKCA, GRIA4, PRKACB, NDUFA5

Imipramine

hsa04724

Glutamatergic synapse

3.36E-04

P48058, O15399, P22694, P17252, P63218, P50151, P15104

GRIA4, GRIN2D, PRKACB, PRKCA, GNG5, GNG10, GLUL

Imipramine

hsa04725

Cholinergic synapse

3.74E-02

P22694, Q14643, P10415

PRKACB, ITPR1, BCL2

Imipramine

hsa04726

Serotonergic synapse

2.69E-03

P22694, P17252, P31645, P04049

PRKACB, PRKCA, SLC6A4, RAF1

Imipramine

hsa04727

GABAergic synapse

2.44E-03

P63218, P50151, P15104

GNG5, GNG10, GLUL

Imipramine

hsa04730

Long-term depression

2.64E-03

Q14344, P08069, P04049, P07948

GNA13, IGF1R, RAF1, LYN

Imipramine

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Imipramine

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Imipramine

hsa04810

Regulation of actin cytoskeleton

3.81E-02

P04049

RAF1

Imipramine

hsa04910

Insulin signaling pathway

2.51E-03

P22694, P06737, P04049, P49841

PRKACB, PYGL, RAF1, GSK3B

Imipramine

hsa04911

Insulin secretion

3.01E-02

P22694, P17252

PRKACB, PRKCA

Imipramine

hsa04912

GnRH signaling pathway

1.82E-02

P04049

RAF1

Imipramine

hsa04913

Ovarian steroidogenesis

2.13E-05

P42330, P22694, P08069

AKR1C3, PRKACB, IGF1R

Imipramine

hsa04914

Progesterone-mediated oocyte maturation

2.97E-04

P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049

IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1

Imipramine

hsa04915

Estrogen signaling pathway

2.99E-02

P04049

RAF1

Imipramine

hsa04916

Melanogenesis

1.33E-02

P04049

RAF1

Imipramine

hsa04917

Prolactin signaling pathway

6.63E-03

P04049

RAF1

Imipramine

hsa04918

Thyroid hormone synthesis

1.94E-03

P22694, P17252, P27824

PRKACB, PRKCA, CANX

Imipramine

hsa04919

Thyroid hormone signaling pathway

6.83E-04

P49841, P04049, P22694, O60244, Q9NVC6

GSK3B, RAF1, PRKACB, MED14, MED17

Imipramine

hsa04921

Oxytocin signaling pathway

2.32E-02

P04049

RAF1

Imipramine

hsa04924

Renin secretion

2.90E-04

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Imipramine

hsa04925

Aldosterone synthesis and secretion

9.86E-03

P17252, P22694, P20020

PRKCA, PRKACB, ATP2B1

Imipramine

hsa04926

Relaxin signaling pathway

6.24E-03

P18848, P22694, P14780, P04049, P30679

ATF4, PRKACB, MMP9, RAF1, GNA15

Imipramine

hsa04927

Cortisol synthesis and secretion

1.27E-03

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Imipramine

hsa04928

Parathyroid hormone synthesis, secretion and action

2.75E-03

Q14643, P22694, P23771, P04049, P10415

ITPR1, PRKACB, GATA3, RAF1, BCL2

Imipramine

hsa04929

GnRH secretion

4.98E-03

P04049

RAF1

Imipramine

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Imipramine

hsa04932

Non-alcoholic fatty liver disease

4.65E-07

P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, O15239, Q16718, O14521

TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, NDUFA1, NDUFA5, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Imipramine

hsa04934

Cushing syndrome

4.74E-02

Q14643, P22694, P04628

ITPR1, PRKACB, WNT1

Imipramine

hsa04935

Growth hormone synthesis, secretion and action

2.16E-02

P04049

RAF1

Imipramine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Imipramine

hsa04961

Endocrine and other factor-regulated calcium reabsorption

9.85E-05

P20020, P17252, P22694

ATP2B1, PRKCA, PRKACB

Imipramine

hsa04962

Vasopressin-regulated water reabsorption

6.61E-03

P22694, Q13561

PRKACB, DCTN2

Imipramine

hsa04964

Proximal tubule bicarbonate reclamation

2.17E-03

P00918

CA2

Imipramine

hsa04966

Collecting duct acid secretion

9.41E-05

P02730, P00918

SLC4A1, CA2

Imipramine

hsa04970

Salivary secretion

2.08E-05

P07550, P22694, Q14643, P20020, P17252, P49913

ADRB2, PRKACB, ITPR1, ATP2B1, PRKCA, CAMP

Imipramine

hsa04972

Pancreatic secretion

6.57E-05

P20020, P17252, Q08828, P62491

ATP2B1, PRKCA, ADCY1, RAB11A

Imipramine

hsa04976

Bile secretion

1.16E-04

O43315, P22694, P08183

AQP9, PRKACB, ABCB1

Imipramine

hsa05010

Alzheimer disease

1.12E-04

O15239, P13073, O15399, Q9NZJ5, O75460, P0DP24, Q13564, P01584, P18848, Q71U36, O15169, P67870, P09603, P05141, P12236, P21796, P28070, P43686

NDUFA1, COX4I1, GRIN2D, EIF2AK3, ERN1, CALM2, APPBP1, IL1B, ATF4, TUBA1A, AXIN1, CSNK2B, CSF1, SLC25A5, SLC25A6, VDAC1, PSMB4, PSMC4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.753
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.839
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.707
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.728
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.873
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.742
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.85
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	O15169	AXIN1	Axin-1	0.712
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P67870	CSNK2B	Casein kinase II subunit beta	0.733
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.789
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P12236	SLC25A6	ADP/ATP translocase 3	0.766
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.88
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P28070	PSMB4	Proteasome subunit beta type-4	0.73
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.707
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.728
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.873
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.85
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.789
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.88

Imipramine

hsa05012

Parkinson disease

2.05E-04

O15239, P13073, P05141, P12236, O75460, P18848, P28070, P43686, P0DP24, Q13557

NDUFA1, COX4I1, SLC25A5, SLC25A6, ERN1, ATF4, PSMB4, PSMC4, CALM2, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.753
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.839
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P12236	SLC25A6	ADP/ATP translocase 3	0.766
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.742
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P28070	PSMB4	Proteasome subunit beta type-4	0.73
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75

Imipramine

hsa05016

Huntington disease

1.34E-05

O15239, P13073, Q9GZM3, P24928, P30876, P62487, P52435, P05141, Q9NYC9, O75460

NDUFA1, COX4I1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, DNAH9, ERN1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9GZM3	POLR2J2	DNA-directed RNA polymerase II subunit RPB11-b1	0.76
P61073	CXCR4	C-X-C chemokine receptor type 4	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.714
P02768	ALB	Albumin	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.708
P61073	CXCR4	C-X-C chemokine receptor type 4	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.756
P02768	ALB	Albumin	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.78
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	P52435	POLR2J	DNA-directed RNA polymerase II subunit RPB11-a	0.76
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9GZM3	POLR2J2	DNA-directed RNA polymerase II subunit RPB11-b1	0.76
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9NYC9	DNAH9	Dynein axonemal heavy chain 9	0.785
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P61073	CXCR4	C-X-C chemokine receptor type 4	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.714
P02768	ALB	Albumin	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.708
P61073	CXCR4	C-X-C chemokine receptor type 4	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.756
P02768	ALB	Albumin	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.78
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702

Imipramine

hsa05017

Spinocerebellar ataxia

1.29E-02

P28070, P28074, P43686, P05141, P12236

PSMB4, PSMB5, PSMC4, SLC25A5, SLC25A6

Imipramine

hsa05020

Prion disease

1.31E-06

P13591, P01584, P46531, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P12236, P28070, P43686, P49841, P67870, P51636, Q16539

NCAM1, IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, GSK3B, CSNK2B, CAV2, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	P13591	NCAM1	Neural cell adhesion molecule 1	0.701
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.75
P02768	ALB	Albumin	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.72
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.753
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.839
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.742
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P12236	SLC25A6	ADP/ATP translocase 3	0.766
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P28070	PSMB4	Proteasome subunit beta type-4	0.73
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P67870	CSNK2B	Casein kinase II subunit beta	0.733
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P51636	CAV2	Caveolin-2	-0.75
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P02768	ALB	Albumin	P13591	NCAM1	Neural cell adhesion molecule 1	0.701
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.72
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Imipramine

hsa05022

Pathways of neurodegeneration - multiple diseases

2.34E-07

P49841, P67870, O15239, Q16718, O14521, P13073, O75460, P18848, Q13561, P48058, P05141, P12236, P17252, P20333, Q16539, O15169, P01584, Q08752, P0DP24, Q13557, P28070, P43686

GSK3B, CSNK2B, NDUFA1, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, GRIA4, SLC25A5, SLC25A6, PRKCA, TNFRSF1B, MAPK14, AXIN1, IL1B, PPID, CALM2, CAMK2D, PSMB4, PSMC4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P67870	CSNK2B	Casein kinase II subunit beta	0.733
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.753
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.837
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.839
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.742
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	Q13561	DCTN2	Dynactin subunit 2	0.812
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	P48058	GRIA4	Glutamate receptor 4	0.707
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P12236	SLC25A6	ADP/ATP translocase 3	0.766
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	P17252	PRKCA	Protein kinase C alpha type	-0.727
P61073	CXCR4	C-X-C chemokine receptor type 4	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.706
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.879
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	O15169	AXIN1	Axin-1	0.712
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.804
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P28070	PSMB4	Proteasome subunit beta type-4	0.73
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P61073	CXCR4	C-X-C chemokine receptor type 4	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.706
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75

Imipramine

hsa05031

Amphetamine addiction

1.94E-03

P48058, P22694, P18848, P17252, Q13547

GRIA4, PRKACB, ATF4, PRKCA, HDAC1

Imipramine

hsa05032

Morphine addiction

1.34E-02

P63218, P50151, Q07343, P43250

GNG5, GNG10, PDE4B, GRK6

Imipramine

hsa05034

Alcoholism

1.81E-06

Q13547, P04049, Q93077, P58876, P62807, Q16778, O60814, P68431

HDAC1, RAF1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Imipramine

hsa05100

Bacterial invasion of epithelial cells

1.82E-03

Q14141, Q05397, Q92529, Q96JJ3

SEPT6, PTK2, SHC3, ELMO2

Imipramine

hsa05110

Vibrio cholerae infection

3.01E-02

P17252, P22694

PRKCA, PRKACB

Imipramine

hsa05131

Shigellosis

3.32E-03

P01375, O00463, Q04759, Q9UDY8, Q9H1Y0, P20810, O43524, P10415, Q96A32

TNF, TRAF5, PRKCQ, MALT1, ATG5, CAST, FOXO3, BCL2, MYLPF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P19652	ORM2	Alpha-1-acid glycoprotein 2	P01375	TNF	Tumor necrosis factor	0.871
P02763	ORM1	Alpha-1-acid glycoprotein 1	P01375	TNF	Tumor necrosis factor	0.871
P19652	ORM2	Alpha-1-acid glycoprotein 2	O00463	TRAF5	TNF receptor-associated factor 5	-0.796
P02763	ORM1	Alpha-1-acid glycoprotein 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.796
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q04759	PRKCQ	Protein kinase C theta type	-0.802
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q04759	PRKCQ	Protein kinase C theta type	-0.802
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.766
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.766
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9H1Y0	ATG5	Autophagy protein 5	-0.75
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9H1Y0	ATG5	Autophagy protein 5	-0.75
P19652	ORM2	Alpha-1-acid glycoprotein 2	P20810	CAST	Calpastatin	-0.775
P02763	ORM1	Alpha-1-acid glycoprotein 1	P20810	CAST	Calpastatin	-0.775
P19652	ORM2	Alpha-1-acid glycoprotein 2	O43524	FOXO3	Forkhead box protein O3	0.736
P02763	ORM1	Alpha-1-acid glycoprotein 1	O43524	FOXO3	Forkhead box protein O3	0.736
P19652	ORM2	Alpha-1-acid glycoprotein 2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P02763	ORM1	Alpha-1-acid glycoprotein 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.726
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.726
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P08246	ELA2	Neutrophil elastase	Q9H1Y0	ATG5	Autophagy protein 5	-0.759
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.724

Imipramine

hsa05132

Salmonella infection

4.98E-02

P04049

RAF1

Imipramine

hsa05133

Pertussis

3.47E-04

P0C0L4

C4A

Imipramine

hsa05134

Legionellosis

1.28E-02

P01584, P68104, P11142

IL1B, EEF1A1, HSPA8

Imipramine

hsa05135

Yersinia infection

3.29E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Imipramine

hsa05140

Leishmaniasis

1.56E-02

P14598, P42224, P25963, P29350, Q15080

NCF1, STAT1, NFKBIA, PTPN6, NCF4

Imipramine

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Imipramine

hsa05144

Malaria

6.73E-06

P69905, P68871, O60603, P01375, P35443, P26718

HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Imipramine

hsa05146

Amoebiasis

2.41E-02

P19875, P01375, P30679, P22694

CXCL2, TNF, GNA15, PRKACB

Imipramine

hsa05150

Staphylococcus aureus infection

1.17E-04

P0C0L4, P21730, P21462, O75015, P13646, P12838, P49913

C4A, C5AR1, FPR1, FCGR3B, KRT13, DEFA4, CAMP

Imipramine

hsa05152

Tuberculosis

1.17E-03

P04049, O75015, P48382, O60603, P01375, P10415, P49913, Q9UDY8

RAF1, FCGR3B, RFX5, TLR2, TNF, BCL2, CAMP, MALT1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P19652	ORM2	Alpha-1-acid glycoprotein 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.753
P02763	ORM1	Alpha-1-acid glycoprotein 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.753
P19652	ORM2	Alpha-1-acid glycoprotein 2	P48382	RFX5	DNA-binding protein RFX5	-0.912
P02763	ORM1	Alpha-1-acid glycoprotein 1	P48382	RFX5	DNA-binding protein RFX5	-0.912
P19652	ORM2	Alpha-1-acid glycoprotein 2	O60603	TLR2	Toll-like receptor 2	0.783
P02763	ORM1	Alpha-1-acid glycoprotein 1	O60603	TLR2	Toll-like receptor 2	0.783
P19652	ORM2	Alpha-1-acid glycoprotein 2	P01375	TNF	Tumor necrosis factor	0.871
P02763	ORM1	Alpha-1-acid glycoprotein 1	P01375	TNF	Tumor necrosis factor	0.871
P19652	ORM2	Alpha-1-acid glycoprotein 2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P02763	ORM1	Alpha-1-acid glycoprotein 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P19652	ORM2	Alpha-1-acid glycoprotein 2	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P02763	ORM1	Alpha-1-acid glycoprotein 1	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.766
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.766
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P08246	ELA2	Neutrophil elastase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.71
P08246	ELA2	Neutrophil elastase	P48382	RFX5	DNA-binding protein RFX5	-0.895
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734

Imipramine

hsa05160

Hepatitis C

1.40E-03

P60033, P04049, P49841, P01375, P48023

CD81, RAF1, GSK3B, TNF, FASLG

Imipramine

hsa05161

Hepatitis B

1.99E-02

P04049

RAF1

Imipramine

hsa05162

Measles

4.02E-02

P11142, P01584, Q9NP90

HSPA8, IL1B, RAB9B

Imipramine

hsa05163

Human cytomegalovirus infection

4.98E-02

P04049

RAF1

Imipramine

hsa05164

Influenza A

3.65E-02

P04049

RAF1

Imipramine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

3.15E-02

P04049

RAF1

Imipramine

hsa05168

Herpes simplex virus 1 infection

3.38E-03

P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212

Imipramine

hsa05170

Human immunodeficiency virus 1 infection

3.48E-02

P04049

RAF1

Imipramine

hsa05171

Coronavirus disease - COVID-19

5.35E-08

P01584, P23396, P62753, P25398, P62249, P42677, P40429, P36578, Q02878, P62917, P32969, P27635, Q07020, P46776, P62910, P18077, P05386, P62829

IL1B, RPS3, RPS6, RPS12, RPS16, RPS27, RPL13A, RPL4, RPL6, RPL8, RPL9, RPL10, RPL18, RPL27A, RPL32, RPL35A, RPLP1, RPL23

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P23396	RPS3	40S ribosomal protein S3	0.886
P02768	ALB	Albumin	P62753	RPS6	40S ribosomal protein S6	0.769
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P62753	RPS6	40S ribosomal protein S6	0.739
P02768	ALB	Albumin	P25398	RPS12	40S ribosomal protein S12	0.775
P09211	GSTP1	Glutathione S-transferase P	P62249	RPS16	40S ribosomal protein S16	0.702
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P62249	RPS16	40S ribosomal protein S16	0.818
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P42677	RPS27	40S ribosomal protein S27	0.834
P09211	GSTP1	Glutathione S-transferase P	P40429	RPL13A	60S ribosomal protein L13a	0.741
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P40429	RPL13A	60S ribosomal protein L13a	0.825
P02768	ALB	Albumin	P36578	RPL4	60S ribosomal protein L4	0.708
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P36578	RPL4	60S ribosomal protein L4	0.823
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	Q02878	RPL6	60S ribosomal protein L6	0.819
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P62917	RPL8	60S ribosomal protein L8	0.866
P02768	ALB	Albumin	P32969	RPL9	60S ribosomal protein L9	0.795
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P32969	RPL9	60S ribosomal protein L9	0.722
P09211	GSTP1	Glutathione S-transferase P	P27635	RPL10	60S ribosomal protein L10	0.772
P09211	GSTP1	Glutathione S-transferase P	Q07020	RPL18	60S ribosomal protein L18	0.779
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	Q07020	RPL18	60S ribosomal protein L18	0.802
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P46776	RPL27A	60S ribosomal protein L27a	0.758
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P62910	RPL32	60S ribosomal protein L32	0.804
P02768	ALB	Albumin	P18077	RPL35A	60S ribosomal protein L35a	0.7
P09211	GSTP1	Glutathione S-transferase P	P05386	RPLP1	60S acidic ribosomal protein P1	0.707
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P05386	RPLP1	60S acidic ribosomal protein P1	0.881
P02768	ALB	Albumin	P62829	RPL23	60S ribosomal protein L23	0.757
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P62753	RPS6	40S ribosomal protein S6	0.769
P02768	ALB	Albumin	P25398	RPS12	40S ribosomal protein S12	0.775
P09211	GSTP1	Glutathione S-transferase P	P62249	RPS16	40S ribosomal protein S16	0.702
P09211	GSTP1	Glutathione S-transferase P	P40429	RPL13A	60S ribosomal protein L13a	0.741
P02768	ALB	Albumin	P36578	RPL4	60S ribosomal protein L4	0.708
P02768	ALB	Albumin	P32969	RPL9	60S ribosomal protein L9	0.795
P09211	GSTP1	Glutathione S-transferase P	P27635	RPL10	60S ribosomal protein L10	0.772
P09211	GSTP1	Glutathione S-transferase P	Q07020	RPL18	60S ribosomal protein L18	0.779
P02768	ALB	Albumin	P18077	RPL35A	60S ribosomal protein L35a	0.7
P09211	GSTP1	Glutathione S-transferase P	P05386	RPLP1	60S acidic ribosomal protein P1	0.707
P02768	ALB	Albumin	P62829	RPL23	60S ribosomal protein L23	0.757

Imipramine

hsa05202

Transcriptional misregulation in cancer

1.25E-04

Q15532, P41732, P14780, P27930, P14923, Q16548, P11215, Q13077, O15550, P08069, P35226, P05164, P08246, Q13547, P12980, P24522

SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, ITGAM, TRAF1, UTX, IGF1R, BMI1, MPO, ELA2, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769

Imipramine

hsa05203

Viral carcinogenesis

1.22E-03

Q13547, Q15283, P58876, P62807, Q16778, O60814

HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Imipramine

hsa05204

Chemical carcinogenesis

1.09E-03

P09211, P78417, P11712

GSTP1, GSTO1, CYP2C9

Imipramine

hsa05205

Proteoglycans in cancer

3.95E-04

Q12955, P04049, Q14247, P14780, P17252, P01375, P08069, P23588, Q13635, P22694, P08962

ANK3, RAF1, CTTN, MMP9, PRKCA, TNF, IGF1R, EIF4B, PTCH1, PRKACB, CD63

Imipramine

hsa05206

MicroRNAs in cancer

3.15E-02

P04049

RAF1

Imipramine

hsa05210

Colorectal cancer

1.66E-02

P04049

RAF1

Imipramine

hsa05211

Renal cell carcinoma

1.16E-02

P04049

RAF1

Imipramine

hsa05212

Pancreatic cancer

1.16E-02

P04049

RAF1

Imipramine

hsa05213

Endometrial cancer

9.95E-03

P04049

RAF1

Imipramine

hsa05214

Glioma

9.08E-05

P08069, P04049

IGF1R, RAF1

Imipramine

hsa05215

Prostate cancer

1.65E-04

P08069, P04049

IGF1R, RAF1

Imipramine

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Imipramine

hsa05218

Melanoma

7.23E-05

P08069, P09619, Q9GZP0, Q02750, P04049

IGF1R, PDGFRB, PDGFD, MAP2K1, RAF1

Imipramine

hsa05219

Bladder cancer

4.98E-03

P04049

RAF1

Imipramine

hsa05220

Chronic myeloid leukemia

9.95E-03

P04049

RAF1

Imipramine

hsa05221

Acute myeloid leukemia

8.29E-03

P04049

RAF1

Imipramine

hsa05223

Non-small cell lung cancer

6.95E-04

P10826, P04049, Q9HC35, O75293

RARB, RAF1, EML4, GADD45B

Imipramine

hsa05224

Breast cancer

1.47E-03

P04049, P46531, Q9UM47, P08069, O15169

RAF1, NOTCH1, NOTCH3, IGF1R, AXIN1

Imipramine

hsa05225

Hepatocellular carcinoma

1.65E-04

P04049, P08069

RAF1, IGF1R

Imipramine

hsa05226

Gastric cancer

8.29E-03

P04049

RAF1

Imipramine

hsa05230

Central carbon metabolism in cancer

9.95E-03

P04049

RAF1

Imipramine

hsa05231

Choline metabolism in cancer

1.49E-03

Q02750, P04049, P09619, Q9GZP0, O15245

MAP2K1, RAF1, PDGFRB, PDGFD, SLC22A1

Imipramine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.21E-03

P07766, P06239, P04049, Q9HC35, P01730

CD3E, LCK, RAF1, EML4, CD4

Imipramine

hsa05310

Asthma

1.35E-02

P13765, P29965

HLA-DOB, CD40LG

Imipramine

hsa05320

Autoimmune thyroid disease

3.16E-02

P13765, P29965

HLA-DOB, CD40LG

Imipramine

hsa05321

Inflammatory bowel disease

1.91E-02

P01375, Q14765, Q9UL17

TNF, STAT4, TBX21

Imipramine

hsa05322

Systemic lupus erythematosus

4.80E-06

P09871, Q93077, P58876, P62807, Q16778, O60814, P68431

C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08246	ELA2	Neutrophil elastase	P05455	SSB	Lupus La protein	-0.717

Imipramine

hsa05330

Allograft rejection

1.76E-03

P13765, P29965, P48023, P01375

HLA-DOB, CD40LG, FASLG, TNF

Imipramine

hsa05332

Graft-versus-host disease

7.27E-04

P48023, P01375, P26715, Q13241

FASLG, TNF, KLRC1, KLRD1

Imipramine

hsa05340

Primary immunodeficiency

1.28E-03

P01730, P11912, P07766, P06239

CD4, CD79A, CD3E, LCK

Imipramine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

3.75E-05

Q8IZS8, P54284, P14923, P08514, P13612, Q9UJU2

CACNA2D3, CACNB3, JUP, ITGA2B, ITGA4, LEF1

Imipramine

hsa05414

Dilated cardiomyopathy

2.58E-03

Q8IZS8, P54284, P13612, P26678

CACNA2D3, CACNB3, ITGA4, PLN

Imipramine

hsa05415

Diabetic cardiomyopathy

4.88E-06

P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557, P04406

PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2D, GAPDH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P17252	PRKCA	Protein kinase C alpha type	-0.732
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	P17252	PRKCA	Protein kinase C alpha type	0.707
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	P14598	NCF1	Neutrophil cytosol factor 1	-0.738
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	Q15080	NCF4	Neutrophil cytosol factor 4	-0.723
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.754
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P09960	LTA4H	Leukotriene A-4 hydrolase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.725
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75

Imipramine

hsa05416

Viral myocarditis

4.29E-02

P13765, P29965

HLA-DOB, CD40LG

Trimipramine

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Trimipramine

hsa00040

Pentose and glucuronate interconversions

4.00E-02

P15121

AKR1B1

Trimipramine

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Trimipramine

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Trimipramine

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Trimipramine

hsa00220

Arginine biosynthesis

1.97E-02

P15104, P49448

GLUL, GLUD2

Trimipramine

hsa00230

Purine metabolism

4.93E-02

P21589

NT5E

Trimipramine

hsa00240

Pyrimidine metabolism

3.20E-03

P21589, P04183

NT5E, TK1

Trimipramine

hsa00250

Alanine, aspartate and glutamate metabolism

1.97E-02

P49448, P15104

GLUD2, GLUL

Trimipramine

hsa00500

Starch and sucrose metabolism

1.67E-02

O43451, P06737

MGAM, PYGL

Trimipramine

hsa00513

Various types of N-glycan biosynthesis

4.96E-02

Q9NR34

MAN1C1

Trimipramine

hsa00564

Glycerophospholipid metabolism

4.29E-02

Q6P1A2, P23743

MBOAT5, DGKA

Trimipramine

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Trimipramine

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Trimipramine

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Trimipramine

hsa00600

Sphingolipid metabolism

3.76E-02

P15289

ARSA

Trimipramine

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.87E-03

P06865, O15466, Q9H4F1

HEXA, ST8SIA5, ST6GALNAC4

Trimipramine

hsa00620

Pyruvate metabolism

3.90E-02

P07195, P11766

LDHB, ADH5

Trimipramine

hsa00730

Thiamine metabolism

5.29E-03

P05186, P24666

ALPL, ACP1

Trimipramine

hsa00760

Nicotinate and nicotinamide metabolism

6.37E-04

P21589

NT5E

Trimipramine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Trimipramine

hsa00790

Folate biosynthesis

2.02E-02

P15121

AKR1B1

Trimipramine

hsa00830

Retinol metabolism

3.15E-02

P00325

ADH1B

Trimipramine

hsa00910

Nitrogen metabolism

1.97E-02

P15104, P49448

GLUL, GLUD2

Trimipramine

hsa00970

Aminoacyl-tRNA biosynthesis

2.12E-02

P14868

DARS

Trimipramine

hsa00980

Metabolism of xenobiotics by cytochrome P450

6.38E-04

P78417, P09211, P11712

GSTO1, GSTP1, CYP2C9

Trimipramine

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Trimipramine

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Trimipramine

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Trimipramine

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Trimipramine

hsa01240

Biosynthesis of cofactors

2.52E-02

Q9BQB6, P14550

VKORC1, AKR1A1

Trimipramine

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P04049

RAF1

Trimipramine

hsa01522

Endocrine resistance

2.16E-02

P04049

RAF1

Trimipramine

hsa01523

Antifolate resistance

3.80E-02

Q92820, P04818

GGH, TYMS

Trimipramine

hsa02010

ABC transporters

2.17E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Trimipramine

hsa03010

Ribosome

1.08E-04

P62753, P25398, P32969, P40429, P62829, Q07020, P18077, P36578, P27635, P05386, P62249

RPS6, RPS12, RPL9, RPL13A, RPL23, RPL18, RPL35A, RPL4, RPL10, RPLP1, RPS16

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	P62753	RPS6	40S ribosomal protein S6	0.769
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P62753	RPS6	40S ribosomal protein S6	0.739
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P42677	RPS27	40S ribosomal protein S27	0.834
P02768	ALB	Albumin	P25398	RPS12	40S ribosomal protein S12	0.775
P02768	ALB	Albumin	P32969	RPL9	60S ribosomal protein L9	0.795
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P32969	RPL9	60S ribosomal protein L9	0.722
P09211	GSTP1	Glutathione S-transferase P	P40429	RPL13A	60S ribosomal protein L13a	0.741
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P40429	RPL13A	60S ribosomal protein L13a	0.825
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P62917	RPL8	60S ribosomal protein L8	0.866
P02768	ALB	Albumin	P62829	RPL23	60S ribosomal protein L23	0.757
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P46776	RPL27A	60S ribosomal protein L27a	0.758
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	Q9H0U6	MRPL18	39S ribosomal protein L18, mitochondrial	0.831
P09211	GSTP1	Glutathione S-transferase P	Q07020	RPL18	60S ribosomal protein L18	0.779
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	Q07020	RPL18	60S ribosomal protein L18	0.802
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P62910	RPL32	60S ribosomal protein L32	0.804
P02768	ALB	Albumin	P18077	RPL35A	60S ribosomal protein L35a	0.7
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	Q02878	RPL6	60S ribosomal protein L6	0.819
P02768	ALB	Albumin	P36578	RPL4	60S ribosomal protein L4	0.708
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P36578	RPL4	60S ribosomal protein L4	0.823
P09211	GSTP1	Glutathione S-transferase P	P27635	RPL10	60S ribosomal protein L10	0.772
P09211	GSTP1	Glutathione S-transferase P	P05386	RPLP1	60S acidic ribosomal protein P1	0.707
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P05386	RPLP1	60S acidic ribosomal protein P1	0.881
P09211	GSTP1	Glutathione S-transferase P	P62249	RPS16	40S ribosomal protein S16	0.702
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P62249	RPS16	40S ribosomal protein S16	0.818
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P23396	RPS3	40S ribosomal protein S3	0.886
P02768	ALB	Albumin	P62753	RPS6	40S ribosomal protein S6	0.769
P02768	ALB	Albumin	P25398	RPS12	40S ribosomal protein S12	0.775
P02768	ALB	Albumin	P32969	RPL9	60S ribosomal protein L9	0.795
P09211	GSTP1	Glutathione S-transferase P	P40429	RPL13A	60S ribosomal protein L13a	0.741
P02768	ALB	Albumin	P62829	RPL23	60S ribosomal protein L23	0.757
P09211	GSTP1	Glutathione S-transferase P	Q07020	RPL18	60S ribosomal protein L18	0.779
P02768	ALB	Albumin	P18077	RPL35A	60S ribosomal protein L35a	0.7
P02768	ALB	Albumin	P36578	RPL4	60S ribosomal protein L4	0.708
P09211	GSTP1	Glutathione S-transferase P	P27635	RPL10	60S ribosomal protein L10	0.772
P09211	GSTP1	Glutathione S-transferase P	P05386	RPLP1	60S acidic ribosomal protein P1	0.707
P09211	GSTP1	Glutathione S-transferase P	P62249	RPS16	40S ribosomal protein S16	0.702

Trimipramine

hsa03013

RNA transport

4.92E-03

P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22748	CA4	Carbonic anhydrase 4	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.879
P22748	CA4	Carbonic anhydrase 4	O14893	GEMIN2	Gem-associated protein 2	-0.709
P22748	CA4	Carbonic anhydrase 4	P61326	MAGOH	Protein mago nashi homolog	-0.822
P22748	CA4	Carbonic anhydrase 4	Q7Z3B4	NUP54	Nucleoporin p54	-0.776
P22748	CA4	Carbonic anhydrase 4	P35658	NUP214	Nuclear pore complex protein Nup214	0.827
P22748	CA4	Carbonic anhydrase 4	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.786
P22748	CA4	Carbonic anhydrase 4	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.869
P22748	CA4	Carbonic anhydrase 4	P78345	RPP38	Ribonuclease P protein subunit p38	-0.731
P22748	CA4	Carbonic anhydrase 4	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.912
P08246	ELA2	Neutrophil elastase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.852
P22748	CA4	Carbonic anhydrase 4	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.879
P08246	ELA2	Neutrophil elastase	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.732
P08246	ELA2	Neutrophil elastase	O14893	GEMIN2	Gem-associated protein 2	-0.785
P22748	CA4	Carbonic anhydrase 4	O14893	GEMIN2	Gem-associated protein 2	-0.709
P22748	CA4	Carbonic anhydrase 4	P61326	MAGOH	Protein mago nashi homolog	-0.822
P08246	ELA2	Neutrophil elastase	Q7Z3B4	NUP54	Nucleoporin p54	-0.723
P22748	CA4	Carbonic anhydrase 4	Q7Z3B4	NUP54	Nucleoporin p54	-0.776
P08246	ELA2	Neutrophil elastase	P35658	NUP214	Nuclear pore complex protein Nup214	0.765
P22748	CA4	Carbonic anhydrase 4	P35658	NUP214	Nuclear pore complex protein Nup214	0.827
P08246	ELA2	Neutrophil elastase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.722
P22748	CA4	Carbonic anhydrase 4	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.786
P08246	ELA2	Neutrophil elastase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.825
P22748	CA4	Carbonic anhydrase 4	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.869
P08246	ELA2	Neutrophil elastase	P78345	RPP38	Ribonuclease P protein subunit p38	-0.795
P22748	CA4	Carbonic anhydrase 4	P78345	RPP38	Ribonuclease P protein subunit p38	-0.731
P08246	ELA2	Neutrophil elastase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.849
P22748	CA4	Carbonic anhydrase 4	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.912

Trimipramine

hsa03020

RNA polymerase

1.27E-04

P30876, P24928, P62487

POLR2B, POLR2A, POLR2G

Trimipramine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Trimipramine

hsa03050

Proteasome

1.21E-02

P28074

PSMB5

Trimipramine

hsa03060

Protein export

4.46E-03

Q15070, O76094

OXA1L, SRP72

Trimipramine

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Trimipramine

hsa03410

Base excision repair

2.52E-02

P49005, P29372

POLD2, MPG

Trimipramine

hsa03430

Mismatch repair

4.38E-02

P20585

MSH3

Trimipramine

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Trimipramine

hsa03460

Fanconi anemia pathway

2.71E-02

O94782

USP1

Trimipramine

hsa04010

MAPK signaling pathway

4.15E-02

P04049

RAF1

Trimipramine

hsa04012

ErbB signaling pathway

1.82E-02

P04049

RAF1

Trimipramine

hsa04014

Ras signaling pathway

3.65E-02

P04049

RAF1

Trimipramine

hsa04015

Rap1 signaling pathway

3.75E-04

P04049, P06213, P25116, Q8TEU7, O00522, P08514, P17252

RAF1, INSR, F2R, RAPGEF6, KRIT1, ITGA2B, PRKCA

Trimipramine

hsa04022

cGMP-PKG signaling pathway

6.45E-03

P04049, P18848, Q8WYR1, P05141, P0DP24

RAF1, ATF4, PIK3R5, SLC25A5, CALM2

Trimipramine

hsa04024

cAMP signaling pathway

2.49E-02

P04049

RAF1

Trimipramine

hsa04060

Cytokine-cytokine receptor interaction

4.71E-02

P78552, O75509

IL13RA1, TNFRSF21

Trimipramine

hsa04062

Chemokine signaling pathway

3.98E-02

P04049

RAF1

Trimipramine

hsa04064

NF-kappa B signaling pathway

1.91E-04

P10415, Q13489, P25963, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45A

Trimipramine

hsa04068

FoxO signaling pathway

1.99E-02

P04049

RAF1

Trimipramine

hsa04071

Sphingolipid signaling pathway

1.10E-06

P04049, P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2

RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.935
P22748	CA4	Carbonic anhydrase 4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.814
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.935
P19652	ORM2	Alpha-1-acid glycoprotein 2	P01375	TNF	Tumor necrosis factor	0.871
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P02763	ORM1	Alpha-1-acid glycoprotein 1	P01375	TNF	Tumor necrosis factor	0.871
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.838
P22748	CA4	Carbonic anhydrase 4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.758
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.838
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.727
P22748	CA4	Carbonic anhydrase 4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.88
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.727
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P19652	ORM2	Alpha-1-acid glycoprotein 2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P22748	CA4	Carbonic anhydrase 4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.863
P02763	ORM1	Alpha-1-acid glycoprotein 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P08246	ELA2	Neutrophil elastase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.725
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P08246	ELA2	Neutrophil elastase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.797
P22748	CA4	Carbonic anhydrase 4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.814
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P07550	ADRB2	Beta-2 adrenergic receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.712
P08246	ELA2	Neutrophil elastase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.865
P22748	CA4	Carbonic anhydrase 4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.758
P08246	ELA2	Neutrophil elastase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.847
P22748	CA4	Carbonic anhydrase 4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.88
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P22748	CA4	Carbonic anhydrase 4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.863
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866

Trimipramine

hsa04072

Phospholipase D signaling pathway

7.52E-04

P04049, Q92529, Q14344

RAF1, SHC3, GNA13

Trimipramine

hsa04080

Neuroactive ligand-receptor interaction

1.02E-03

P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, P07550

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, ADRB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P08311	CTSG	Cathepsin G	-0.71
P07550	ADRB2	Beta-2 adrenergic receptor	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	-0.77
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.832
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	1
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.726
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	O00398	P2RY10	Putative P2Y purinoceptor 10	0.768
P07550	ADRB2	Beta-2 adrenergic receptor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.717
P21453	S1PR1	Sphingosine 1-phosphate receptor 1	P07550	ADRB2	Beta-2 adrenergic receptor	0.704
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P07550	ADRB2	Beta-2 adrenergic receptor	P28472	GABRB3	Gamma-aminobutyric acid receptor subunit beta-3	-0.77
P08246	ELA2	Neutrophil elastase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.846
P07550	ADRB2	Beta-2 adrenergic receptor	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.704
P08246	ELA2	Neutrophil elastase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.725
P07550	ADRB2	Beta-2 adrenergic receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.809
P08246	ELA2	Neutrophil elastase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.797
P08246	ELA2	Neutrophil elastase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.793
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P07550	ADRB2	Beta-2 adrenergic receptor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.717
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P07550	ADRB2	Beta-2 adrenergic receptor	P07550	ADRB2	Beta-2 adrenergic receptor	1

Trimipramine

hsa04110

Cell cycle

6.80E-03

P06493, O75293, P30304, P33981, P42773, P01106

CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC

Trimipramine

hsa04114

Oocyte meiosis

6.23E-03

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Trimipramine

hsa04115

p53 signaling pathway

3.57E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Trimipramine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Trimipramine

hsa04140

Autophagy - animal

2.82E-02

P04049

RAF1

Trimipramine

hsa04141

Protein processing in endoplasmic reticulum

4.88E-02

P18848, O60337, P11142, P07900

ATF4, MARH6, HSPA8, HSP90AA1

Trimipramine

hsa04145

Phagosome

1.98E-02

Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765

NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Trimipramine

hsa04146

Peroxisome

2.42E-02

O43933, P56589, Q9UKG9, O75521, P33121

PEX1, PEX3, CROT, ECI2, ACSL1

Trimipramine

hsa04150

mTOR signaling pathway

2.32E-02

P04049

RAF1

Trimipramine

hsa04151

PI3K-Akt signaling pathway

1.24E-03

P62753, P43657, O43521, P27348, P09603, Q9GZP0, Q8WYR1, P63218, P50151, P13612, O15335, Q13751, P18848, O00141, Q6ZUJ8

RPS6, P2RY5, BCL2L11, YWHAQ, CSF1, PDGFD, PIK3R5, GNG5, GNG10, ITGA4, CHAD, LAMB3, ATF4, SGK, PIK3AP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P61073	CXCR4	C-X-C chemokine receptor type 4	P62753	RPS6	40S ribosomal protein S6	0.709
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P61073	CXCR4	C-X-C chemokine receptor type 4	P27348	YWHAQ	14-3-3 protein theta	0.708
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.789
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.736
P61073	CXCR4	C-X-C chemokine receptor type 4	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.76
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.844
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.902
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P13612	ITGA4	Integrin alpha-4	0.77
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	O15335	CHAD	Chondroadherin	-0.729
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q13751	LAMB3	Laminin subunit beta-3	-0.794
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P61073	CXCR4	C-X-C chemokine receptor type 4	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.755
P61073	CXCR4	C-X-C chemokine receptor type 4	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.728
P61073	CXCR4	C-X-C chemokine receptor type 4	P62753	RPS6	40S ribosomal protein S6	0.709
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P61073	CXCR4	C-X-C chemokine receptor type 4	P27348	YWHAQ	14-3-3 protein theta	0.708
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.789
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.736
P61073	CXCR4	C-X-C chemokine receptor type 4	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.76
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.844
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.902
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P13612	ITGA4	Integrin alpha-4	0.77
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	O15335	CHAD	Chondroadherin	-0.729
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q13751	LAMB3	Laminin subunit beta-3	-0.794
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P61073	CXCR4	C-X-C chemokine receptor type 4	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.755
P61073	CXCR4	C-X-C chemokine receptor type 4	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.728

Trimipramine

hsa04210

Apoptosis

5.34E-05

Q13315, P10415, Q13489, O76075, P25963, P01375, Q9NR28, O75460, P24522, Q16548, Q13077, O43521, P18848, Q14643, P04049

ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, DIABLO, ERN1, GADD45A, BCL2A1, TRAF1, BCL2L11, ATF4, ITPR1, RAF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1

Trimipramine

hsa04213

Longevity regulating pathway - multiple species

2.85E-02

Q9Y4H2, Q13547

IRS2, HDAC1

Trimipramine

hsa04217

Necroptosis

8.10E-07

P01375, P48023, Q14765, P07900, P15104, P05141, P01584, P0C0S5, Q99878, Q13557, Q9H444

TNF, FASLG, STAT4, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CAMK2D, CHMP4B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	P01568	IFNA21	Interferon alpha-21	0.838
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.785
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.799
P61073	CXCR4	C-X-C chemokine receptor type 4	P15104	GLUL	Glutamine synthetase	0.754
P02768	ALB	Albumin	P15104	GLUL	Glutamine synthetase	0.717
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P61073	CXCR4	C-X-C chemokine receptor type 4	P0C0S5	H2AFZ	Histone H2A.Z	0.732
P02768	ALB	Albumin	P0C0S5	H2AFZ	Histone H2A.Z	0.756
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P61073	CXCR4	C-X-C chemokine receptor type 4	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.731
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.702
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.817
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P61073	CXCR4	C-X-C chemokine receptor type 4	P15104	GLUL	Glutamine synthetase	0.754
P02768	ALB	Albumin	P15104	GLUL	Glutamine synthetase	0.717
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P61073	CXCR4	C-X-C chemokine receptor type 4	P0C0S5	H2AFZ	Histone H2A.Z	0.732
P02768	ALB	Albumin	P0C0S5	H2AFZ	Histone H2A.Z	0.756
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P61073	CXCR4	C-X-C chemokine receptor type 4	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.731

Trimipramine

hsa04218

Cellular senescence

8.08E-03

P01106, P04049, O75293, P30304, P06493

MYC, RAF1, GADD45B, CDC25A, CDK1

Trimipramine

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Trimipramine

hsa04270

Vascular smooth muscle contraction

2.32E-02

P04049

RAF1

Trimipramine

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Trimipramine

hsa04360

Axon guidance

2.49E-02

P04049

RAF1

Trimipramine

hsa04370

VEGF signaling pathway

2.77E-04

P16298, Q05397, Q02750, P04049

PPP3CB, PTK2, MAP2K1, RAF1

Trimipramine

hsa04371

Apelin signaling pathway

2.65E-02

P04049

RAF1

Trimipramine

hsa04510

Focal adhesion

3.48E-02

P04049

RAF1

Trimipramine

hsa04512

ECM-receptor interaction

4.41E-02

Q13751, P13612, O15335

LAMB3, ITGA4, CHAD

Trimipramine

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Trimipramine

hsa04540

Gap junction

1.33E-02

P04049

RAF1

Trimipramine

hsa04550

Signaling pathways regulating pluripotency of stem cells

9.61E-03

Q13873, P04049, Q02750, Q86SE9

BMPR2, RAF1, MAP2K1, PCGF5

Trimipramine

hsa04610

Complement and coagulation cascades

6.23E-06

P0C0L4

C4A

Trimipramine

hsa04611

Platelet activation

3.39E-02

P25116, P08514, P07359

F2R, ITGA2B, GP1BA

Trimipramine

hsa04612

Antigen processing and presentation

1.07E-03

Q14953, P26715, P26717, Q13241, P01732, P01375

KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Trimipramine

hsa04613

Neutrophil extracellular trap formation

1.84E-09

P17252, P04049, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PRKCA, RAF1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P19652	ORM2	Alpha-1-acid glycoprotein 2	O60603	TLR2	Toll-like receptor 2	0.783
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
P02763	ORM1	Alpha-1-acid glycoprotein 1	O60603	TLR2	Toll-like receptor 2	0.783
P19652	ORM2	Alpha-1-acid glycoprotein 2	P05164	MPO	Myeloperoxidase	0.897
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P02763	ORM1	Alpha-1-acid glycoprotein 1	P05164	MPO	Myeloperoxidase	0.897
P19652	ORM2	Alpha-1-acid glycoprotein 2	P08246	ELA2	Neutrophil elastase	0.934
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P02763	ORM1	Alpha-1-acid glycoprotein 1	P08246	ELA2	Neutrophil elastase	0.934
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.897
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.897
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.755
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.755
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q15080	NCF4	Neutrophil cytosol factor 4	0.839
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.839
P19652	ORM2	Alpha-1-acid glycoprotein 2	P20160	AZU1	Azurocidin	0.863
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
P02763	ORM1	Alpha-1-acid glycoprotein 1	P20160	AZU1	Azurocidin	0.863
P19652	ORM2	Alpha-1-acid glycoprotein 2	P08311	CTSG	Cathepsin G	0.826
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P02763	ORM1	Alpha-1-acid glycoprotein 1	P08311	CTSG	Cathepsin G	0.826
P19652	ORM2	Alpha-1-acid glycoprotein 2	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P02763	ORM1	Alpha-1-acid glycoprotein 1	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P19652	ORM2	Alpha-1-acid glycoprotein 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.753
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P02763	ORM1	Alpha-1-acid glycoprotein 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.753
P19652	ORM2	Alpha-1-acid glycoprotein 2	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.751
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
P02763	ORM1	Alpha-1-acid glycoprotein 1	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.751
P19652	ORM2	Alpha-1-acid glycoprotein 2	P21462	FPR1	fMet-Leu-Phe receptor	0.815
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
P02763	ORM1	Alpha-1-acid glycoprotein 1	P21462	FPR1	fMet-Leu-Phe receptor	0.815
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767

Trimipramine

hsa04621

NOD-like receptor signaling pathway

3.10E-03

Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838

ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9H1Y0	ATG5	Autophagy protein 5	-0.75
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9H1Y0	ATG5	Autophagy protein 5	-0.75
P19652	ORM2	Alpha-1-acid glycoprotein 2	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.739
P02763	ORM1	Alpha-1-acid glycoprotein 1	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.739
P19652	ORM2	Alpha-1-acid glycoprotein 2	O00463	TRAF5	TNF receptor-associated factor 5	-0.796
P02763	ORM1	Alpha-1-acid glycoprotein 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.796
P19652	ORM2	Alpha-1-acid glycoprotein 2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P02763	ORM1	Alpha-1-acid glycoprotein 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q05823	RNASEL	2-5A-dependent ribonuclease	0.771
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q05823	RNASEL	2-5A-dependent ribonuclease	0.771
P19652	ORM2	Alpha-1-acid glycoprotein 2	P01375	TNF	Tumor necrosis factor	0.871
P02763	ORM1	Alpha-1-acid glycoprotein 1	P01375	TNF	Tumor necrosis factor	0.871
P19652	ORM2	Alpha-1-acid glycoprotein 2	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P02763	ORM1	Alpha-1-acid glycoprotein 1	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P19652	ORM2	Alpha-1-acid glycoprotein 2	P12838	DEFA4	Neutrophil defensin 4	0.815
P02763	ORM1	Alpha-1-acid glycoprotein 1	P12838	DEFA4	Neutrophil defensin 4	0.815
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	Q9H1Y0	ATG5	Autophagy protein 5	-0.759
P08246	ELA2	Neutrophil elastase	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.702
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.734
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709

Trimipramine

hsa04625

C-type lectin receptor signaling pathway

1.49E-02

P04049

RAF1

Trimipramine

hsa04630

JAK-STAT signaling pathway

1.49E-02

P04049

RAF1

Trimipramine

hsa04640

Hematopoietic cell lineage

3.69E-02

P21926, P07766, P01730, P09564

CD9, CD3E, CD4, CD7

Trimipramine

hsa04650

Natural killer cell mediated cytotoxicity

5.84E-06

P16298, P50591, P01375, P20963, Q02750, P04049, Q13241, P26718, P26717, Q14953, P26715

PPP3CB, TNFSF10, TNF, CD247, MAP2K1, RAF1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	P17252	PRKCA	Protein kinase C alpha type	-0.727
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.71
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.717
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.717
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Trimipramine

hsa04657

IL-17 signaling pathway

5.66E-05

P07900, O00463, Q16539, P49841, P19875, P14780, Q9UJX4, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL2, MMP9, ANAPC5, LCN2, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P22748	CA4	Carbonic anhydrase 4	O00463	TRAF5	TNF receptor-associated factor 5	-0.826
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P22748	CA4	Carbonic anhydrase 4	Q9UJX4	ANAPC5	Anaphase-promoting complex subunit 5	-0.723
P22748	CA4	Carbonic anhydrase 4	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P07550	ADRB2	Beta-2 adrenergic receptor	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.757
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
P22748	CA4	Carbonic anhydrase 4	O00463	TRAF5	TNF receptor-associated factor 5	-0.826
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P22748	CA4	Carbonic anhydrase 4	Q9UJX4	ANAPC5	Anaphase-promoting complex subunit 5	-0.723
P07550	ADRB2	Beta-2 adrenergic receptor	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.757
P22748	CA4	Carbonic anhydrase 4	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718

Trimipramine

hsa04660

T cell receptor signaling pathway

8.18E-03

P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P04049

TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, RAF1

Trimipramine

hsa04662

B cell receptor signaling pathway

9.95E-03

P04049

RAF1

Trimipramine

hsa04664

Fc epsilon RI signaling pathway

1.16E-02

P04049

RAF1

Trimipramine

hsa04666

Fc gamma R-mediated phagocytosis

2.32E-02

P04049

RAF1

Trimipramine

hsa04668

TNF signaling pathway

2.79E-04

P01375, O00463, Q13489, P25963, P18848, P19875, P01584, P20749, Q13077, P14780, P20333

TNF, TRAF5, BIRC3, NFKBIA, ATF4, CXCL2, IL1B, BCL3, TRAF1, MMP9, TNFRSF1B

Trimipramine

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Trimipramine

hsa04672

Intestinal immune network for IgA production

1.35E-02

P29965, P13765

CD40LG, HLA-DOB

Trimipramine

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Trimipramine

hsa04720

Long-term potentiation

4.88E-03

P16298, P51812, Q02750, P04049

PPP3CB, RPS6KA3, MAP2K1, RAF1

Trimipramine

hsa04722

Neurotrophin signaling pathway

7.10E-03

P04049, P49841, O43524, P48023

RAF1, GSK3B, FOXO3, FASLG

Trimipramine

hsa04724

Glutamatergic synapse

9.51E-03

O15399, P63218, P50151, P15104

GRIN2D, GNG5, GNG10, GLUL

Trimipramine

hsa04726

Serotonergic synapse

1.33E-02

P04049

RAF1

Trimipramine

hsa04727

GABAergic synapse

2.33E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Trimipramine

hsa04730

Long-term depression

1.26E-03

Q14344, P04049, P07948

GNA13, RAF1, LYN

Trimipramine

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Trimipramine

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Trimipramine

hsa04810

Regulation of actin cytoskeleton

3.81E-02

P04049

RAF1

Trimipramine

hsa04910

Insulin signaling pathway

2.51E-03

P22694, P06737, P04049, P49841

PRKACB, PYGL, RAF1, GSK3B

Trimipramine

hsa04912

GnRH signaling pathway

1.82E-02

P04049

RAF1

Trimipramine

hsa04913

Ovarian steroidogenesis

2.45E-03

P42330, P22694, P06213

AKR1C3, PRKACB, INSR

Trimipramine

hsa04914

Progesterone-mediated oocyte maturation

1.91E-03

Q17RY0, Q9Y6D9, P51812, Q02750, P04049

CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1

Trimipramine

hsa04915

Estrogen signaling pathway

2.99E-02

P04049

RAF1

Trimipramine

hsa04916

Melanogenesis

1.33E-02

P04049

RAF1

Trimipramine

hsa04917

Prolactin signaling pathway

6.63E-03

P04049

RAF1

Trimipramine

hsa04918

Thyroid hormone synthesis

3.16E-02

P17252, P27824

PRKCA, CANX

Trimipramine

hsa04919

Thyroid hormone signaling pathway

6.83E-04

P49841, P04049, P22694, O60244, Q9NVC6

GSK3B, RAF1, PRKACB, MED14, MED17

Trimipramine

hsa04920

Adipocytokine signaling pathway

4.49E-02

P25963, P33121, Q04759, P01375

NFKBIA, ACSL1, PRKCQ, TNF

Trimipramine

hsa04921

Oxytocin signaling pathway

2.32E-02

P04049

RAF1

Trimipramine

hsa04923

Regulation of lipolysis in adipocytes

3.76E-02

P06213

INSR

Trimipramine

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Trimipramine

hsa04926

Relaxin signaling pathway

6.24E-03

P18848, P22694, P14780, P04049, P30679

ATF4, PRKACB, MMP9, RAF1, GNA15

Trimipramine

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Trimipramine

hsa04928

Parathyroid hormone synthesis, secretion and action

1.99E-02

P04049

RAF1

Trimipramine

hsa04929

GnRH secretion

4.98E-03

P04049

RAF1

Trimipramine

hsa04930

Type II diabetes mellitus

3.14E-02

P06213

INSR

Trimipramine

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Trimipramine

hsa04932

Non-alcoholic fatty liver disease

4.65E-07

P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, O15239, Q16718, O14521

TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, NDUFA1, NDUFA5, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Trimipramine

hsa04935

Growth hormone synthesis, secretion and action

2.16E-02

P04049

RAF1

Trimipramine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Trimipramine

hsa04960

Aldosterone-regulated sodium reabsorption

2.32E-03

P06213, P48048

INSR, KCNJ1

Trimipramine

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Trimipramine

hsa04966

Collecting duct acid secretion

1.38E-03

P02730, P00918

SLC4A1, CA2

Trimipramine

hsa04970

Salivary secretion

2.82E-03

P07550, P22694, Q14643, P17252, P49913

ADRB2, PRKACB, ITPR1, PRKCA, CAMP

Trimipramine

hsa04972

Pancreatic secretion

1.31E-02

Q08828, P62491

ADCY1, RAB11A

Trimipramine

hsa04976

Bile secretion

1.67E-03

O43315, P22694, P08183

AQP9, PRKACB, ABCB1

Trimipramine

hsa05010

Alzheimer disease

4.88E-03

P13073, O15399, Q9NZJ5, O75460, P0DP24, Q13564, P01584, P18848, Q71U36, P09603, P05141, P21796

COX4I1, GRIN2D, EIF2AK3, ERN1, CALM2, APPBP1, IL1B, ATF4, TUBA1A, CSF1, SLC25A5, VDAC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.753
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.839
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.707
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.728
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.873
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.742
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.85
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	O15169	AXIN1	Axin-1	0.712
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P67870	CSNK2B	Casein kinase II subunit beta	0.733
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.789
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P12236	SLC25A6	ADP/ATP translocase 3	0.766
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.88
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P28070	PSMB4	Proteasome subunit beta type-4	0.73
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.707
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.728
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.873
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.85
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.789
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.88

Trimipramine

hsa05012

Parkinson disease

2.77E-03

O15239, P13073, P05141, O75460, P18848, P0DP24, Q13557

NDUFA1, COX4I1, SLC25A5, ERN1, ATF4, CALM2, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.753
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.839
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P12236	SLC25A6	ADP/ATP translocase 3	0.766
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.742
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P28070	PSMB4	Proteasome subunit beta type-4	0.73
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75

Trimipramine

hsa05016

Huntington disease

4.33E-03

O15239, P13073, P24928, P30876, P62487, P05141, O75460

NDUFA1, COX4I1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9GZM3	POLR2J2	DNA-directed RNA polymerase II subunit RPB11-b1	0.76
P61073	CXCR4	C-X-C chemokine receptor type 4	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.714
P02768	ALB	Albumin	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.708
P61073	CXCR4	C-X-C chemokine receptor type 4	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.756
P02768	ALB	Albumin	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.78
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	P52435	POLR2J	DNA-directed RNA polymerase II subunit RPB11-a	0.76
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9GZM3	POLR2J2	DNA-directed RNA polymerase II subunit RPB11-b1	0.76
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9NYC9	DNAH9	Dynein axonemal heavy chain 9	0.785
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P61073	CXCR4	C-X-C chemokine receptor type 4	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.714
P02768	ALB	Albumin	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.708
P61073	CXCR4	C-X-C chemokine receptor type 4	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.756
P02768	ALB	Albumin	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.78
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702

Trimipramine

hsa05017

Spinocerebellar ataxia

2.43E-02

P28074

PSMB5

Trimipramine

hsa05020

Prion disease

3.73E-04

P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539

NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	P13591	NCAM1	Neural cell adhesion molecule 1	0.701
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.75
P02768	ALB	Albumin	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.72
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.753
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.839
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.742
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P12236	SLC25A6	ADP/ATP translocase 3	0.766
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P28070	PSMB4	Proteasome subunit beta type-4	0.73
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P67870	CSNK2B	Casein kinase II subunit beta	0.733
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P51636	CAV2	Caveolin-2	-0.75
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P02768	ALB	Albumin	P13591	NCAM1	Neural cell adhesion molecule 1	0.701
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.72
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Trimipramine

hsa05022

Pathways of neurodegeneration - multiple diseases

9.19E-05

P49841, O15239, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P20333, Q16539, P01584, Q08752, P0DP24, Q13557

GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, IL1B, PPID, CALM2, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P67870	CSNK2B	Casein kinase II subunit beta	0.733
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.753
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.837
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.839
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.742
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	Q13561	DCTN2	Dynactin subunit 2	0.812
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	P48058	GRIA4	Glutamate receptor 4	0.707
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P05141	SLC25A5	ADP/ATP translocase 2	0.721
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P12236	SLC25A6	ADP/ATP translocase 3	0.766
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	P17252	PRKCA	Protein kinase C alpha type	-0.727
P61073	CXCR4	C-X-C chemokine receptor type 4	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.706
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.879
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	O15169	AXIN1	Axin-1	0.712
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P16389	KCNA2	Potassium voltage-gated channel subfamily A member 2	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.804
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P28070	PSMB4	Proteasome subunit beta type-4	0.73
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P02768	ALB	Albumin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.88
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P61073	CXCR4	C-X-C chemokine receptor type 4	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.706
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75

Trimipramine

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Trimipramine

hsa05032

Morphine addiction

1.34E-02

P63218, P50151, Q07343, P43250

GNG5, GNG10, PDE4B, GRK6

Trimipramine

hsa05034

Alcoholism

1.81E-06

Q13547, P04049, Q93077, P58876, P62807, Q16778, O60814, P68431

HDAC1, RAF1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Trimipramine

hsa05100

Bacterial invasion of epithelial cells

2.85E-02

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Trimipramine

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P19652	ORM2	Alpha-1-acid glycoprotein 2	P01375	TNF	Tumor necrosis factor	0.871
P02763	ORM1	Alpha-1-acid glycoprotein 1	P01375	TNF	Tumor necrosis factor	0.871
P19652	ORM2	Alpha-1-acid glycoprotein 2	O00463	TRAF5	TNF receptor-associated factor 5	-0.796
P02763	ORM1	Alpha-1-acid glycoprotein 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.796
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q04759	PRKCQ	Protein kinase C theta type	-0.802
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q04759	PRKCQ	Protein kinase C theta type	-0.802
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.766
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.766
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9H1Y0	ATG5	Autophagy protein 5	-0.75
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9H1Y0	ATG5	Autophagy protein 5	-0.75
P19652	ORM2	Alpha-1-acid glycoprotein 2	P20810	CAST	Calpastatin	-0.775
P02763	ORM1	Alpha-1-acid glycoprotein 1	P20810	CAST	Calpastatin	-0.775
P19652	ORM2	Alpha-1-acid glycoprotein 2	O43524	FOXO3	Forkhead box protein O3	0.736
P02763	ORM1	Alpha-1-acid glycoprotein 1	O43524	FOXO3	Forkhead box protein O3	0.736
P19652	ORM2	Alpha-1-acid glycoprotein 2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P02763	ORM1	Alpha-1-acid glycoprotein 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.726
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.726
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P08246	ELA2	Neutrophil elastase	Q9H1Y0	ATG5	Autophagy protein 5	-0.759
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.724

Trimipramine

hsa05132

Salmonella infection

1.81E-02

P51617, P25963, P01375, P04049, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509

IRAK1, NFKBIA, TNF, RAF1, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3

Trimipramine

hsa05133

Pertussis

4.24E-03

P0C0L4

C4A

Trimipramine

hsa05134

Legionellosis

1.28E-02

P01584, P68104, P11142

IL1B, EEF1A1, HSPA8

Trimipramine

hsa05135

Yersinia infection

3.29E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Trimipramine

hsa05140

Leishmaniasis

1.18E-02

P14598, P13765, O60603, P25963, P01375, P51617, Q15080

NCF1, HLA-DOB, TLR2, NFKBIA, TNF, IRAK1, NCF4

Trimipramine

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Trimipramine

hsa05144

Malaria

1.44E-03

P69905, P68871, P01375, P35443, P26718

HBA2, HBB, TNF, THBS4, KLRK1

Trimipramine

hsa05145

Toxoplasmosis

3.07E-02

P51617, P25963, P01375, P10415, Q13489, P13765, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2

Trimipramine

hsa05146

Amoebiasis

2.41E-02

P19875, P01375, P30679, P22694

CXCL2, TNF, GNA15, PRKACB

Trimipramine

hsa05152

Tuberculosis

1.41E-02

P04049, Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

RAF1, TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P19652	ORM2	Alpha-1-acid glycoprotein 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.753
P02763	ORM1	Alpha-1-acid glycoprotein 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.753
P19652	ORM2	Alpha-1-acid glycoprotein 2	P48382	RFX5	DNA-binding protein RFX5	-0.912
P02763	ORM1	Alpha-1-acid glycoprotein 1	P48382	RFX5	DNA-binding protein RFX5	-0.912
P19652	ORM2	Alpha-1-acid glycoprotein 2	O60603	TLR2	Toll-like receptor 2	0.783
P02763	ORM1	Alpha-1-acid glycoprotein 1	O60603	TLR2	Toll-like receptor 2	0.783
P19652	ORM2	Alpha-1-acid glycoprotein 2	P01375	TNF	Tumor necrosis factor	0.871
P02763	ORM1	Alpha-1-acid glycoprotein 1	P01375	TNF	Tumor necrosis factor	0.871
P19652	ORM2	Alpha-1-acid glycoprotein 2	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P02763	ORM1	Alpha-1-acid glycoprotein 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.791
P19652	ORM2	Alpha-1-acid glycoprotein 2	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P02763	ORM1	Alpha-1-acid glycoprotein 1	P49913	CAMP	Cathelicidin antimicrobial peptide	0.832
P19652	ORM2	Alpha-1-acid glycoprotein 2	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.766
P02763	ORM1	Alpha-1-acid glycoprotein 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.766
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P08246	ELA2	Neutrophil elastase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.71
P08246	ELA2	Neutrophil elastase	P48382	RFX5	DNA-binding protein RFX5	-0.895
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734

Trimipramine

hsa05160

Hepatitis C

1.40E-03

P60033, P04049, P49841, P01375, P48023

CD81, RAF1, GSK3B, TNF, FASLG

Trimipramine

hsa05161

Hepatitis B

4.82E-03

P17252, P04049, P14780, P25963, P01375, P10415, P51617, O60603, Q14765

PRKCA, RAF1, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4

Trimipramine

hsa05162

Measles

4.02E-02

P11142, P01584, Q9NP90

HSPA8, IL1B, RAB9B

Trimipramine

hsa05163

Human cytomegalovirus infection

4.98E-02

P04049

RAF1

Trimipramine

hsa05164

Influenza A

3.65E-02

P04049

RAF1

Trimipramine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

3.15E-02

P04049

RAF1

Trimipramine

hsa05170

Human immunodeficiency virus 1 infection

2.93E-04

P04049, P01375, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5

RAF1, TNF, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2

Trimipramine

hsa05171

Coronavirus disease - COVID-19

6.98E-05

P01584, P62753, P25398, P62249, P40429, P36578, P32969, P27635, Q07020, P18077, P05386, P62829

IL1B, RPS6, RPS12, RPS16, RPL13A, RPL4, RPL9, RPL10, RPL18, RPL35A, RPLP1, RPL23

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P23396	RPS3	40S ribosomal protein S3	0.886
P02768	ALB	Albumin	P62753	RPS6	40S ribosomal protein S6	0.769
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P62753	RPS6	40S ribosomal protein S6	0.739
P02768	ALB	Albumin	P25398	RPS12	40S ribosomal protein S12	0.775
P09211	GSTP1	Glutathione S-transferase P	P62249	RPS16	40S ribosomal protein S16	0.702
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P62249	RPS16	40S ribosomal protein S16	0.818
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P42677	RPS27	40S ribosomal protein S27	0.834
P09211	GSTP1	Glutathione S-transferase P	P40429	RPL13A	60S ribosomal protein L13a	0.741
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P40429	RPL13A	60S ribosomal protein L13a	0.825
P02768	ALB	Albumin	P36578	RPL4	60S ribosomal protein L4	0.708
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P36578	RPL4	60S ribosomal protein L4	0.823
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	Q02878	RPL6	60S ribosomal protein L6	0.819
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P62917	RPL8	60S ribosomal protein L8	0.866
P02768	ALB	Albumin	P32969	RPL9	60S ribosomal protein L9	0.795
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P32969	RPL9	60S ribosomal protein L9	0.722
P09211	GSTP1	Glutathione S-transferase P	P27635	RPL10	60S ribosomal protein L10	0.772
P09211	GSTP1	Glutathione S-transferase P	Q07020	RPL18	60S ribosomal protein L18	0.779
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	Q07020	RPL18	60S ribosomal protein L18	0.802
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P46776	RPL27A	60S ribosomal protein L27a	0.758
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P62910	RPL32	60S ribosomal protein L32	0.804
P02768	ALB	Albumin	P18077	RPL35A	60S ribosomal protein L35a	0.7
P09211	GSTP1	Glutathione S-transferase P	P05386	RPLP1	60S acidic ribosomal protein P1	0.707
Q9ULS6	KCNS2	Potassium voltage-gated channel subfamily S member 2	P05386	RPLP1	60S acidic ribosomal protein P1	0.881
P02768	ALB	Albumin	P62829	RPL23	60S ribosomal protein L23	0.757
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718
P02768	ALB	Albumin	P62753	RPS6	40S ribosomal protein S6	0.769
P02768	ALB	Albumin	P25398	RPS12	40S ribosomal protein S12	0.775
P09211	GSTP1	Glutathione S-transferase P	P62249	RPS16	40S ribosomal protein S16	0.702
P09211	GSTP1	Glutathione S-transferase P	P40429	RPL13A	60S ribosomal protein L13a	0.741
P02768	ALB	Albumin	P36578	RPL4	60S ribosomal protein L4	0.708
P02768	ALB	Albumin	P32969	RPL9	60S ribosomal protein L9	0.795
P09211	GSTP1	Glutathione S-transferase P	P27635	RPL10	60S ribosomal protein L10	0.772
P09211	GSTP1	Glutathione S-transferase P	Q07020	RPL18	60S ribosomal protein L18	0.779
P02768	ALB	Albumin	P18077	RPL35A	60S ribosomal protein L35a	0.7
P09211	GSTP1	Glutathione S-transferase P	P05386	RPLP1	60S acidic ribosomal protein P1	0.707
P02768	ALB	Albumin	P62829	RPL23	60S ribosomal protein L23	0.757

Trimipramine

hsa05202

Transcriptional misregulation in cancer

1.61E-06

Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q16548, P11215, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522

FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, ITGAM, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769

Trimipramine

hsa05203

Viral carcinogenesis

1.22E-03

Q13547, Q15283, P58876, P62807, Q16778, O60814

HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Trimipramine

hsa05204

Chemical carcinogenesis

1.09E-03

P09211, P78417, P11712

GSTP1, GSTO1, CYP2C9

Trimipramine

hsa05205

Proteoglycans in cancer

1.38E-03

Q12955, P04049, Q14247, P14780, P17252, P01375, P23588, Q13635, P22694, P08962

ANK3, RAF1, CTTN, MMP9, PRKCA, TNF, EIF4B, PTCH1, PRKACB, CD63

Trimipramine

hsa05206

MicroRNAs in cancer

3.15E-02

P04049

RAF1

Trimipramine

hsa05210

Colorectal cancer

1.66E-02

P04049

RAF1

Trimipramine

hsa05211

Renal cell carcinoma

1.16E-02

P04049

RAF1

Trimipramine

hsa05212

Pancreatic cancer

1.16E-02

P04049

RAF1

Trimipramine

hsa05213

Endometrial cancer

9.95E-03

P04049

RAF1

Trimipramine

hsa05214

Glioma

9.95E-03

P04049

RAF1

Trimipramine

hsa05215

Prostate cancer

1.33E-02

P04049

RAF1

Trimipramine

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Trimipramine

hsa05218

Melanoma

9.63E-04

P09619, Q9GZP0, Q02750, P04049

PDGFRB, PDGFD, MAP2K1, RAF1

Trimipramine

hsa05219

Bladder cancer

4.98E-03

P04049

RAF1

Trimipramine

hsa05220

Chronic myeloid leukemia

9.95E-03

P04049

RAF1

Trimipramine

hsa05221

Acute myeloid leukemia

8.29E-03

P04049

RAF1

Trimipramine

hsa05222

Small cell lung cancer

2.79E-02

Q13489, P10415, P25963, Q13077, O00463, P24522

BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Trimipramine

hsa05223

Non-small cell lung cancer

6.95E-04

P10826, P04049, Q9HC35, O75293

RARB, RAF1, EML4, GADD45B

Trimipramine

hsa05224

Breast cancer

1.49E-02

P04049

RAF1

Trimipramine

hsa05225

Hepatocellular carcinoma

6.30E-04

P04049, Q92529, P51531

RAF1, SHC3, SMARCA2

Trimipramine

hsa05226

Gastric cancer

8.29E-03

P04049

RAF1

Trimipramine

hsa05230

Central carbon metabolism in cancer

9.95E-03

P04049

RAF1

Trimipramine

hsa05231

Choline metabolism in cancer

1.49E-03

Q02750, P04049, P09619, Q9GZP0, O15245

MAP2K1, RAF1, PDGFRB, PDGFD, SLC22A1

Trimipramine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.21E-03

P07766, P06239, P04049, Q9HC35, P01730

CD3E, LCK, RAF1, EML4, CD4

Trimipramine

hsa05310

Asthma

1.70E-03

P13765, P29965, P12724, P01375

HLA-DOB, CD40LG, RNASE3, TNF

Trimipramine

hsa05320

Autoimmune thyroid disease

3.16E-02

P13765, P29965

HLA-DOB, CD40LG

Trimipramine

hsa05321

Inflammatory bowel disease

7.13E-04

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Trimipramine

hsa05322

Systemic lupus erythematosus

1.52E-05

P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P05455

ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08246	ELA2	Neutrophil elastase	P05455	SSB	Lupus La protein	-0.717

Trimipramine

hsa05330

Allograft rejection

1.76E-03

P13765, P29965, P48023, P01375

HLA-DOB, CD40LG, FASLG, TNF

Trimipramine

hsa05332

Graft-versus-host disease

2.32E-05

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Trimipramine

hsa05340

Primary immunodeficiency

1.28E-03

P01730, P11912, P07766, P06239

CD4, CD79A, CD3E, LCK

Trimipramine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

2.60E-04

Q8IZS8, P54284, P14923, P08514, P13612, Q9UJU2

CACNA2D3, CACNB3, JUP, ITGA2B, ITGA4, LEF1

Trimipramine

hsa05414

Dilated cardiomyopathy

2.11E-02

Q8IZS8, P54284, P13612, P26678

CACNA2D3, CACNB3, ITGA4, PLN

Trimipramine

hsa05415

Diabetic cardiomyopathy

1.02E-03

P05141, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557

SLC25A5, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09960	LTA4H	Leukotriene A-4 hydrolase	P17252	PRKCA	Protein kinase C alpha type	-0.732
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	P17252	PRKCA	Protein kinase C alpha type	0.707
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	P14598	NCF1	Neutrophil cytosol factor 1	-0.738
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	Q15080	NCF4	Neutrophil cytosol factor 4	-0.723
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
P17658	KCNA6	Potassium voltage-gated channel subfamily A member 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.754
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75
P09960	LTA4H	Leukotriene A-4 hydrolase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.725
P02768	ALB	Albumin	P05141	SLC25A5	ADP/ATP translocase 2	0.81
P02768	ALB	Albumin	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
P02768	ALB	Albumin	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.747
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P02768	ALB	Albumin	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.75

Trimipramine

hsa05416

Viral myocarditis

4.29E-02

P13765, P29965

HLA-DOB, CD40LG

Community members of Imipramine (S_DC: 7.45)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

SLC6A4

SodiumNonedependent serotonin transporter

Reported

0.0477

0.0203

2.0442

P14416

DRD2

D(2) dopamine receptor

Reported

0.0604

0.4779

2.5081

O95259

KCNH1

Potassium voltageNonegated channel subfamily H member 1

Reported

0.0425

0.0465

0.1143

P19652

ORM2

AlphaNone1Noneacid glycoprotein 2

Reported

0.0938

0.0579

0.1628

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

O15245

SLC22A1

Solute carrier family 22 member 1

Predicted

0.0149

0.0219

2.0294

P04156

PRNP

Major prion protein

Predicted

0.5909

0.1737

0.6429

P09211

GSTP1

Glutathione SNonetransferase P

Predicted

0.3204

0.3523

0.4566

1.3213

P25116

F2R

ProteinaseNoneactivated receptor 1

Predicted

0.2038

0.3196

0.5136

1.2547

P52732

KIF11

KinesinNonelike protein KIF11

Predicted

0.0082

0.8281

1.6602

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P22748

CA4

Carbonic anhydrase 4

Predicted

0.0056

0.8267

0.1609

1.8171

P02768

ALB

Albumin

Predicted

0.2848

0.9111

0.0857

2.0502

P61073

CXCR4

CNoneXNoneC chemokine receptor type 4

Predicted

0.2823

0.4018

0.648

1.5927

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P28074

PSMB5

Proteasome subunit beta typeNone5

Predicted

0.2839

0.4723

0.5439

1.6305

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

P22001

KCNA3

Potassium voltageNonegated channel subfamily A member 3

Predicted

0.1396

0.5055

1.0809

P37840

SNCA

AlphaNonesynuclein

Predicted

0.0853

0.1324

0.3321

0.6395

P08069

IGF1R

InsulinNonelike growth factor 1 receptor

Predicted

0.2082

0.9561

0.9883

3.0047

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

P61088

UBE2N

UbiquitinNoneconjugating enzyme E2 N

Predicted

0.1102

0.3825

0.3736

1.1937

P21453

S1PR1

Sphingosine 1Nonephosphate receptor 1

Predicted

0.1434

0.3847

0.221

1.0621

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

P04049

RAF1

RAF protoNoneoncogene serine/threonineNoneprotein kinase

Predicted

0.557

0.7572

2.7929

Q05397

PTK2

Focal adhesion kinase 1

Predicted

0.2153

0.5864

0.9713

2.2518

P16083

NQO2

Ribosyldihydronicotinamide dehydrogenase [quinone]

Predicted

0.2958

0.3134

0.7747

P30531

SLC6A1

SodiumNone and chlorideNonedependent GABA transporter 1

Predicted

0.0889

0.5202

0.1047

1.1894

P48029

SLC6A8

SodiumNone and chlorideNonedependent creatine transporter 1

Predicted

0.2161

0.2328

0.5737

P02763

ORM1

AlphaNone1Noneacid glycoprotein 1

Predicted

0.0553

0.0579

0.1435

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P16389

KCNA2

Potassium voltageNonegated channel subfamily A member 2

Predicted

0.0131

0.0835

0.1736

P22001

KCNA3

Potassium voltageNonegated channel subfamily A member 3

Predicted

0.1396

0.5055

1.0809

P17658

KCNA6

Potassium voltageNonegated channel subfamily A member 6

Predicted

0.2827

0.0785

0.2984

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

Q9ULS6

KCNS2

Potassium voltageNonegated channel subfamily S member 2

Predicted

0.1955

0.0412

0.1801

Gene name	UniProt_ID	Bioactivity	Value (nM)
SLC6A4	P31645	IC50	2.6
SLC6A4	P31645	IC50	5.1
SLC6A4	P31645	IC50	6.8
SLC6A4	P31645	Ki	0.15
SLC6A4	P31645	Ki	0.77
SLC6A4	P31645	Ki	1
DRD2	P14416	IC50	410
DRD2	P14416	Ki	620
DRD2	P14416	Ki	726
SLC6A4	P31645	Ki	149

PharmaCoNets of Imipramine (SPCN: 185.55 )

Imipramine regulated-network (SDN: 24.91)

Community members of Imipramine (SDC: 7.45)

PharmaCoNets of Imipramine (S_PCN: 185.55 )

Imipramine regulated-network (S_DN: 24.91)

Community members of Imipramine (S_DC: 7.45)