PharmaCoNets of Imatinib (SPCN: 290.45 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Imatinibhsa00010Glycolysis / Gluconeogenesis1.89E-035P04075, P14550, P11766, P07195, P60174ALDOA, AKR1A1, ADH5, LDHB, TPI1More
Imatinibhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Imatinibhsa00030Pentose phosphate pathway7.01E-114P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Imatinibhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Imatinibhsa00051Fructose and mannose metabolism2.63E-055P15121, P19367, P08237, P60174, P04075AKR1B1, HK1, PFKM, TPI1, ALDOAMore
Imatinibhsa00052Galactose metabolism1.02E-066P06280, P08237, O43451, P15121, P19367, Q14376GLA, PFKM, MGAM, AKR1B1, HK1, GALEMore
Imatinibhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Imatinibhsa00071Fatty acid degradation2.23E-035P11310, O75521, P00325, P11766, P33121ACADM, ECI2, ADH1B, ADH5, ACSL1More
Imatinibhsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Imatinibhsa00190Oxidative phosphorylation4.50E-063Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Imatinibhsa00220Arginine biosynthesis4.50E-083P15104, P05089, P49448GLUL, ARG1, GLUD2More
Imatinibhsa00230Purine metabolism3.35E-022Q7LG56, P51828RRM2B, ADCY7More
Imatinibhsa00250Alanine, aspartate and glutamate metabolism3.77E-063Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Imatinibhsa00270Cysteine and methionine metabolism2.39E-022Q96RQ9, P40926IL4I1, MDH2More
Imatinibhsa00280Valine, leucine and isoleucine degradation1.93E-046P55809, Q9HCC0, Q96RQ9, P05166, Q02252, P11310OXCT1, MCCC2, IL4I1, PCCB, ALDH6A1, ACADMMore
Imatinibhsa00310Lysine degradation2.14E-057Q9NVH6, Q96KQ7, Q8NEZ4, Q13029, O15047, Q02809, P51648TMLHE, EHMT2, MLL3, PRDM2, SETD1A, PLOD1, ALDH3A2More
Imatinibhsa00330Arginine and proline metabolism2.73E-021P17707AMD1More
Imatinibhsa00380Tryptophan metabolism3.02E-021Q16613AANATMore
Imatinibhsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Imatinibhsa00471D-Glutamine and D-glutamate metabolism1.54E-032Q7Z3D6, P49448C14orf159, GLUD2More
Imatinibhsa00500Starch and sucrose metabolism1.65E-094O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Imatinibhsa00510N-Glycan biosynthesis1.10E-034O94777, P15907, Q9BVK2, Q9NR34DPM2, ST6GAL1, ALG8, MAN1C1More
Imatinibhsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Imatinibhsa00520Amino sugar and nucleotide sugar metabolism2.98E-053Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Imatinibhsa00531Glycosaminoglycan degradation3.78E-021P15586GNSMore
Imatinibhsa00562Inositol phosphate metabolism4.54E-045Q9NRR6, P27987, O14732, P19174, P42338INPP5E, ITPKB, IMPA2, PLCG1, PIK3CBMore
Imatinibhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.28E-032O94777, Q14442DPM2, PIGHMore
Imatinibhsa00564Glycerophospholipid metabolism1.25E-046P48651, Q9Y6K0, P35790, P23743, O14494, Q3LIE5PTDSS1, CEPT1, CHKA, DGKA, PLPP1, ADPRMMore
Imatinibhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Imatinibhsa00590Arachidonic acid metabolism2.48E-033P11712, P09917, P09960CYP2C9, ALOX5, LTA4HMore
Imatinibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Imatinibhsa00600Sphingolipid metabolism2.90E-043Q9BX95, Q06136, P15289SGPP1, FVT1, ARSAMore
Imatinibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.27E-072P06865, O75752HEXA, B3GALNT1More
Imatinibhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Imatinibhsa00620Pyruvate metabolism9.80E-044P40926, P07195, P14550, P11766MDH2, LDHB, AKR1A1, ADH5More
Imatinibhsa00630Glyoxylate and dicarboxylate metabolism1.13E-104P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Imatinibhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Imatinibhsa00670One carbon pool by folate1.72E-053O95954, P04818, Q99707FTCD, TYMS, MTRMore
Imatinibhsa00730Thiamine metabolism2.39E-052P05186, P24666ALPL, ACP1More
Imatinibhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Imatinibhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Imatinibhsa00770Pantothenate and CoA biosynthesis2.82E-053O95498, Q6ZQY3, Q9NRN7VNN2, GADL1, AASDHPPTMore
Imatinibhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Imatinibhsa00790Folate biosynthesis1.04E-023Q92820, P05186, P42330GGH, ALPL, AKR1C3More
Imatinibhsa00830Retinol metabolism2.70E-065P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Imatinibhsa00860Porphyrin and chlorophyll metabolism7.35E-053P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Imatinibhsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Imatinibhsa00910Nitrogen metabolism1.75E-042P15104, P49448GLUL, GLUD2More
Imatinibhsa00970Aminoacyl-tRNA biosynthesis1.30E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Imatinibhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Imatinibhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Imatinibhsa00983Drug metabolism - other enzymes5.42E-095P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Imatinibhsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Imatinibhsa01100Metabolic pathways8.01E-0769Q9NR34, Q9Y234, P35790, P05089, P21953, Q16772, Q9UJ14, P30041, P15104, P19367, P42338, Q9Y217, P48426, P27987, Q96DU7, P22557, Q6ZQY3, P32320, Q08828, Q02153, P20839, P22748, P40926, P55809, P06280, O94777, Q16875, O43286, O43451, P53004, Q9Y6K0, P05186, P24666, P15121, P08237, Q86XP1, O95861, Q96RQ9, Q9HCC0, P33121, Q9UHK6, Q86VZ5, Q96G23, P09917, P48651, Q9BVK2, P57054, Q14442, Q9UNP4, Q9H4F1, Q9BX95, Q9BRR6, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P05166, P14927, P12074, P05496, Q99437, O15239, O15047, Q9NVH6MAN1C1, LIPT1, CHKA, ARG1, BCKDHB, GSTA3, GGTL3, PRDX6, GLUL, HK1, PIK3CB, MTMR6, PIP4K2A, ITPKB, ITPKC, ALAS2, GADL1, CDA, ADCY1, GUCY1B3, IMPDH1, CA4, MDH2, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, BLVRA, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKH, BPNT1, IL4I1, MCCC2, ACSL1, AMACR, SGMS1, LASS2, ALOX5, PTDSS1, ALG8, PIGP, PIGH, ST3GAL5, ST6GALNAC4, SGPP1, ADPGK, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, PCCB, UQCRB, COX6A1, ATP5G1, ATP6V0B, NDUFA1, SETD1A, TMLHEMore
Imatinibhsa01200Carbon metabolism2.13E-022P52209, P37837PGD, TALDO1More
Imatinibhsa01212Fatty acid metabolism4.62E-022P33121, P11310ACSL1, ACADMMore
Imatinibhsa01230Biosynthesis of amino acids2.18E-067P51854, P60891, Q99707, P50213, P05089, P15104, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, GLUL, TALDO1More
Imatinibhsa01240Biosynthesis of cofactors3.32E-057Q969G6, P13716, P36551, P22557, O60701, P14618, Q9Y234RFK, ALAD, CPOX, ALAS2, UGDH, PKM2, LIPT1More
Imatinibhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Imatinibhsa01522Endocrine resistance1.23E-058P04049, Q9UM47, P04637, P42773, P46527, P08069, P10415, Q13323RAF1, NOTCH3, TP53, CDKN2C, CDKN1B, IGF1R, BCL2, BIKMore
Imatinibhsa01523Antifolate resistance2.08E-044P41440, Q92820, P04818, P01375SLC19A1, GGH, TYMS, TNFMore
Imatinibhsa01524Platinum drug resistance2.37E-058Q13489, Q14790, P48023, P78417, P40692, P23025, P52701, P31751BIRC3, CASP8, FASLG, GSTO1, MLH1, XPA, MSH6, AKT2More
Imatinibhsa02010ABC transporters1.66E-043P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Imatinibhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Imatinibhsa03010Ribosome8.92E-1421P26373, P62753, P42677, P25398, P32969, P62917, P62829, P46776, Q9H0U6, Q07020, P62888, P62899, P62910, P18077, P61927, P61513, Q02878, P36578, P27635, P05386, P23396RPL13, RPS6, RPS27, RPS12, RPL9, RPL8, RPL23, RPL27A, MRPL18, RPL18, RPL30, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPL6, RPL4, RPL10, RPLP1, RPS3More
Imatinibhsa03013RNA transport1.66E-2130P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, Q9H777, P11940, P20042, Q14240, Q9BZI7, P23588, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, ELAC1, PABPC1, EIF2S2, EIF4A2, UPF3B, EIF4B, TACC3, EIF2B1, FMR1, FXR1More
Imatinibhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Imatinibhsa03020RNA polymerase3.33E-124P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Imatinibhsa03022Basal transcription factors2.68E-043O00268, Q5H9L4, Q15544TAF4, TAF7L, TAF11More
Imatinibhsa03040Spliceosome3.39E-0818Q14562, O43143, O60508, P17844, P08579, P26368, O75940, P51991, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, DDX5, SNRPB2, U2AF2, SMNDC1, HNRPA3, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Imatinibhsa03050Proteasome4.83E-021P55036PSMD4More
Imatinibhsa03060Protein export3.67E-094Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Imatinibhsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Imatinibhsa03430Mismatch repair4.38E-021P20585MSH3More
Imatinibhsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Imatinibhsa03460Fanconi anemia pathway8.90E-043P40692, O60673, Q9UNA4MLH1, REV3L, POLIMore
Imatinibhsa04010MAPK signaling pathway8.69E-054P04049, P08069, Q9H2K8, Q12933RAF1, IGF1R, TAOK3, TRAF2More
Imatinibhsa04012ErbB signaling pathway3.61E-057Q13153, P16333, Q13191, P19174, P42338, P01106, P04049PAK1, NCK1, CBLB, PLCG1, PIK3CB, MYC, RAF1More
Imatinibhsa04014Ras signaling pathway2.30E-054P04049, P31751, P08069, P0DP23RAF1, AKT2, IGF1R, CALM1More
Imatinibhsa04015Rap1 signaling pathway3.20E-076P04049, P08069, P06213, O00522, P31751, P0DP23RAF1, IGF1R, INSR, KRIT1, AKT2, CALM1More
Imatinibhsa04020Calcium signaling pathway2.78E-0612Q96DU7, Q08828, P21796, P45880, Q13557, P21860, P30679, P0DP24, P0DP23, P05141, P51828, P23634ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, ERBB3, GNA15, CALM2, CALM1, SLC25A5, ADCY7, ATP2B4More
Imatinibhsa04022cGMP-PKG signaling pathway1.15E-0813Q02153, P04049, Q99941, P18848, P23634, Q8WYR1, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, PIK3R5, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Imatinibhsa04024cAMP signaling pathway1.08E-046Q08828, P51828, P31751, P0DP23, P04049, Q13153ADCY1, ADCY7, AKT2, CALM1, RAF1, PAK1More
Imatinibhsa04060Cytokine-cytokine receptor interaction8.92E-0621P14784, P27930, P14778, P37173, P08476, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, P25025, Q9UBD3, P47992, P01375, P09341, P19875, P80075, P18510, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, INHBA, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, CXCR2, XCL2, XCL1, TNF, CXCL1, CXCL2, CCL8, IL1RN, CD4, TNFRSF25More
Imatinibhsa04061Viral protein interaction with cytokine and cytokine receptor3.46E-0710Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Imatinibhsa04062Chemokine signaling pathway5.11E-0720P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q13009, P14598, P42224, P04049, P25963CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, TIAM1, NCF1, STAT1, RAF1, NFKBIAMore
Imatinibhsa04064NF-kappa B signaling pathway1.07E-1825P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Imatinibhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Imatinibhsa04068FoxO signaling pathway4.41E-054P04049, P08069, P48023, Q96BR1RAF1, IGF1R, FASLG, SGK3More
Imatinibhsa04070Phosphatidylinositol signaling system7.50E-0612P19174, P0DP23, Q14643, O14986, P23743, P49619, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252PLCG1, CALM1, ITPR1, PIP5K1B, DGKA, DGKG, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Imatinibhsa04071Sphingolipid signaling pathway1.30E-0713P04049, P17252, P21453, Q9H228, P01375, Q96G23, Q13362, Q9BX95, Q16539, P10415, Q9UQC2, Q12933, Q02156RAF1, PRKCA, S1PR1, EDG8, TNF, LASS2, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2, TRAF2, PRKCEMore
Imatinibhsa04072Phospholipase D signaling pathway1.18E-0513P04049, P31751, P42338, Q9UQC2, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760RAF1, AKT2, PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Imatinibhsa04080Neuroactive ligand-receptor interaction1.86E-0511P08311, P78334, Q15722, P21453, Q9H228, P43657, P21462, P21730, P30939, P07550, P35318CTSG, GABRE, LTB4R, S1PR1, EDG8, P2RY5, FPR1, C5AR1, HTR1F, ADRB2, ADMMore
Imatinibhsa04110Cell cycle4.62E-0712Q9UBD5, P30260, P06493, O60566, Q14683, P04637, P49918, P30304, P33981, P42773, P01106, Q13547ORC3, CDC27, CDK1, BUB1B, SMC1A, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Imatinibhsa04114Oocyte meiosis2.64E-1111Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Imatinibhsa04115p53 signaling pathway2.54E-023O15151, Q13315, P10415MDM4, ATM, BCL2More
Imatinibhsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Imatinibhsa04136Autophagy - other4.46E-052O94817, Q9H1Y0ATG12, ATG5More
Imatinibhsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Imatinibhsa04140Autophagy - animal3.90E-0515P08069, Q9Y4H2, P42338, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, PIK3CB, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Imatinibhsa04141Protein processing in endoplasmic reticulum3.01E-0714P18848, Q12933, P30101, Q15437, Q15436, O60337, P60604, Q99941, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9UNL2ATF4, TRAF2, PDIA3, SEC23B, SEC23A, MARH6, UBE2G2, CREBL1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SSR3More
Imatinibhsa04142Lysosome1.89E-0613Q99437, P25774, O14773, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916, Q04900ATP6V0B, CTSS, TPP1, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2, CD164More
Imatinibhsa04144Endocytosis2.52E-0719Q13191, P0DMV8, P11142, Q9H444, O43633, O75351, P62491, P25024, Q96B97, P43250, Q6WKZ4, Q15438, Q8WU79, Q14161, P14784, O95219, O75154, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, CHMP2A, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, RAB11FIP1, PSCD1, SMAP1L, GIT2, IL2RB, SNX4, RAB11FIP3, SNX12, SNX5More
Imatinibhsa04145Phagosome3.59E-0613O75015, Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Imatinibhsa04146Peroxisome1.01E-036O43933, O00623, P56589, Q9UKG9, O75521, P33121PEX1, PEX12, PEX3, CROT, ECI2, ACSL1More
Imatinibhsa04150mTOR signaling pathway1.32E-035P08069, P04049, Q02750, Q9NQL2, P51812IGF1R, RAF1, MAP2K1, RRAGD, RPS6KA3More
Imatinibhsa04151PI3K-Akt signaling pathway2.13E-1028P62753, P21860, P25116, O43521, P04637, P27348, P49767, Q13362, P07900, Q8WYR1, P62873, P61952, P16144, P02452, P24821, Q16363, P22105, O60603, P23458, P01568, Q99941, P18848, P10415, P17252, Q96BR1, O00141, Q6ZUJ8, P56279RPS6, ERBB3, F2R, BCL2L11, TP53, YWHAQ, VEGFC, PPP2R5C, HSP90AA1, PIK3R5, GNB1, GNG11, ITGB4, COL1A1, TNC, LAMA4, TNXB, TLR2, JAK1, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGK3, SGK, PIK3AP1, TCL1AMore
Imatinibhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Imatinibhsa04210Apoptosis5.52E-0511O76075, Q14790, P01375, P48023, Q9NR28, O75460, Q16548, O43521, P18848, P42575, P04049DFFB, CASP8, TNF, FASLG, DIABLO, ERN1, BCL2A1, BCL2L11, ATF4, CASP2, RAF1More
Imatinibhsa04211Longevity regulating pathway2.10E-057P31751, P08069, Q08828, P51828, Q99941, P18848, Q96RR4AKT2, IGF1R, ADCY1, ADCY7, CREBL1, ATF4, CAMKK2More
Imatinibhsa04213Longevity regulating pathway - multiple species2.09E-099P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Imatinibhsa04217Necroptosis9.96E-1824P01375, Q12933, P01568, P23458, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P07900, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, P10415, Q13557, Q9H444, O43633, O75351, P45880, Q08752TNF, TRAF2, IFNA21, JAK1, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, BCL2, CAMK2D, CHMP4B, CHMP2A, VPS4B, VDAC2, PPIDMore
Imatinibhsa04218Cellular senescence1.96E-047P31751, P04049, P30281, P0DP23, P01889, P10321, P12236AKT2, RAF1, CCND3, CALM1, HLA-B, HLA-C, SLC25A6More
Imatinibhsa04260Cardiac muscle contraction3.70E-046P09493, P07951, P67936, P13073, P12074, P14927TPM1, TPM2, TPM4, COX4I1, COX6A1, UQCRBMore
Imatinibhsa04261Adrenergic signaling in cardiomyocytes3.91E-1015P09493, P67936, Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, P0DP24, Q13557, P17252, P10415, P23634TPM1, TPM4, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CALM2, CAMK2D, PRKCA, BCL2, ATP2B4More
Imatinibhsa04270Vascular smooth muscle contraction3.81E-0811P24723, Q04759, Q14643, P0DP23, P04049, Q08828, P51828, P22694, P35579, P35749, P35318PRKCH, PRKCQ, ITPR1, CALM1, RAF1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADMMore
Imatinibhsa04310Wnt signaling pathway2.28E-045P30279, Q13485, O43318, P17612, P67870CCND2, SMAD4, MAP3K7, PRKACA, CSNK2BMore
Imatinibhsa04330Notch signaling pathway4.54E-044Q92542, P49768, P46531, Q9UM47NCSTN, PSEN1, NOTCH1, NOTCH3More
Imatinibhsa04340Hedgehog signaling pathway2.59E-045P49841, P17612, P22694, Q13635, P10415GSK3B, PRKACA, PRKACB, PTCH1, BCL2More
Imatinibhsa04360Axon guidance4.12E-047P16298, Q05397, Q13873, P42338, P04049, O14639, P24844PPP3CB, PTK2, BMPR2, PIK3CB, RAF1, ABLIM1, MYL9More
Imatinibhsa04370VEGF signaling pathway5.06E-157P19174, P16298, P31751, P42338, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PTK2, MAP2K1, RAF1More
Imatinibhsa04371Apelin signaling pathway1.43E-049P62873, P61952, P31751, P04049, Q08828, P51828, P62753, P0DP23, P0DP24GNB1, GNG11, AKT2, RAF1, ADCY1, ADCY7, RPS6, CALM1, CALM2More
Imatinibhsa04380Osteoclast differentiation2.23E-0914Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Imatinibhsa04390Hippo signaling pathway4.05E-067P35240, O95835, Q92796, P04628, Q9UJU2, O43623, Q13489NF2, LATS1, DLG3, WNT1, LEF1, SNAI2, BIRC3More
Imatinibhsa04392Hippo signaling pathway - multiple species2.11E-053O95835, Q13153, Q6V0I7LATS1, PAK1, FAT4More
Imatinibhsa04510Focal adhesion1.63E-035Q15942, P51636, P30281, P04049, P08069ZYX, CAV2, CCND3, RAF1, IGF1RMore
Imatinibhsa04512ECM-receptor interaction2.77E-056P02452, P24821, P07359, P26012, P08514, P16070COL1A1, TNC, GP1BA, ITGB8, ITGA2B, CD44More
Imatinibhsa04520Adherens junction1.81E-033Q13485, O43318, P08069SMAD4, MAP3K7, IGF1RMore
Imatinibhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Imatinibhsa04540Gap junction6.48E-056P17252, Q13509, P68371, P04049, Q9NRA1, Q14643PRKCA, TUBB3, TUBB2C, RAF1, PDGFC, ITPR1More
Imatinibhsa04550Signaling pathways regulating pluripotency of stem cells1.61E-035Q13873, P04049, Q02750, P08069, Q86SE9BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Imatinibhsa04610Complement and coagulation cascades6.18E-124P09871, P0C0L4, P20023, P05107C1S, C4A, CR2, ITGB2More
Imatinibhsa04611Platelet activation2.65E-056Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Imatinibhsa04612Antigen processing and presentation1.30E-0911P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, P01732, P30101, P11142, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, PDIA3, HSPA8, TNFMore
Imatinibhsa04613Neutrophil extracellular trap formation1.18E-1133P19174, P17252, P04049, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q99878, Q93077, P58876, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PLCG1, PRKCA, RAF1, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Imatinibhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Imatinibhsa04620Toll-like receptor signaling pathway2.48E-055Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Imatinibhsa04621NOD-like receptor signaling pathway2.41E-0517P01584, P07900, Q14643, P23458, P45880, P25963, P10599, P43490, O00463, Q14790, P29728, P01375, P09341, P49913, P59665, P59666, P12838IL1B, HSP90AA1, ITPR1, JAK1, VDAC2, NFKBIA, TXN, PBEF1, TRAF5, CASP8, OAS2, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Imatinibhsa04622RIG-I-like receptor signaling pathway1.29E-075P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Imatinibhsa04623Cytosolic DNA-sensing pathway1.82E-105P01584, P01568, Q13546, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, POLR3H, CCL4L2More
Imatinibhsa04625C-type lectin receptor signaling pathway4.35E-0913Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Imatinibhsa04630JAK-STAT signaling pathway1.01E-048P01106, P31751, P42224, P23458, P14784, P16871, Q13651, P04049MYC, AKT2, STAT1, JAK1, IL2RB, IL7R, IL10RA, RAF1More
Imatinibhsa04640Hematopoietic cell lineage5.69E-1319P13612, P07359, P08514, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, GP1BA, ITGA2B, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Imatinibhsa04650Natural killer cell mediated cytotoxicity3.37E-2319P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Imatinibhsa04657IL-17 signaling pathway9.60E-1115P25963, P07900, P08238, O00463, Q12933, Q07955, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375, P06702, P01584NFKBIA, HSP90AA1, HSP90AB1, TRAF5, TRAF2, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF, S100A9, IL1BMore
Imatinibhsa04658Th1 and Th2 cell differentiation5.66E-3818P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, P23458, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, JAK1, RUNX3More
Imatinibhsa04659Th17 cell differentiation1.45E-2720P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Imatinibhsa04660T cell receptor signaling pathway3.51E-2519P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Imatinibhsa04662B cell receptor signaling pathway2.42E-1313P31751, P42338, P20023, P60033, P13164, P16298, Q8WV28, P07948, P11912, P21854, Q8N149, Q02750, P04049AKT2, PIK3CB, CR2, CD81, IFITM1, PPP3CB, BLNK, LYN, CD79A, CD72, LILRA2, MAP2K1, RAF1More
Imatinibhsa04664Fc epsilon RI signaling pathway5.52E-089P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P04049, P09917, P20292TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, RAF1, ALOX5, ALOX5APMore
Imatinibhsa04666Fc gamma R-mediated phagocytosis4.61E-034P08637, O75015, P04049, P06396FCGR3A, FCGR3B, RAF1, GSNMore
Imatinibhsa04668TNF signaling pathway3.69E-0611P01375, Q12933, O00463, Q16539, Q99941, P18848, P01584, P20749, P14780, P20333, O95429TNF, TRAF2, TRAF5, MAPK14, CREBL1, ATF4, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Imatinibhsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Imatinibhsa04710Circadian rhythm2.11E-031O15516CLOCKMore
Imatinibhsa04713Circadian entrainment1.85E-0710P0DP23, P0DP24, Q13557, Q02153, P17252, P62873, P61952, Q14643, Q08828, P51828CALM1, CALM2, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG11, ITPR1, ADCY1, ADCY7More
Imatinibhsa04714Thermogenesis1.49E-048Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHDMore
Imatinibhsa04720Long-term potentiation4.83E-1212P17252, Q13557, P16298, P0DP23, P0DP24, Q15418, P51812, P18848, Q08828, Q02750, P04049, Q14643PRKCA, CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1, ITPR1More
Imatinibhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Imatinibhsa04722Neurotrophin signaling pathway1.76E-0610Q05655, P31751, P04049, P49841, O43524, P48023, P52566, P51617, P10415, P0DP23PRKCD, AKT2, RAF1, GSK3B, FOXO3, FASLG, ARHGDIB, IRAK1, BCL2, CALM1More
Imatinibhsa04723Retrograde endocannabinoid signaling1.69E-037Q14643, P17252, P62873, P61952, Q08828, O15239, Q16718ITPR1, PRKCA, GNB1, GNG11, ADCY1, NDUFA1, NDUFA5More
Imatinibhsa04724Glutamatergic synapse2.84E-057O15399, Q08828, P62873, P63218, P50151, P61952, P15104GRIN2D, ADCY1, GNB1, GNG5, GNG10, GNG11, GLULMore
Imatinibhsa04725Cholinergic synapse2.86E-0813Q08828, P51828, Q14643, P17252, P62873, P63218, P50151, P61952, P18848, Q13557, P42338, P31751, P10415ADCY1, ADCY7, ITPR1, PRKCA, GNB1, GNG5, GNG10, GNG11, ATF4, CAMK2D, PIK3CB, AKT2, BCL2More
Imatinibhsa04726Serotonergic synapse3.64E-033P62879, P04049, Q02750GNB2, RAF1, MAP2K1More
Imatinibhsa04727GABAergic synapse5.15E-099Q08828, P51828, P62873, P63218, P50151, P61952, P15104, P46459, Q15111ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, GLUL, NSF, PLCL1More
Imatinibhsa04728Dopaminergic synapse2.02E-1018Q14643, P17252, P62873, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP23, P0DP24, O15516, P48058ITPR1, PRKCA, GNB1, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM1, CALM2, CLOCK, GRIA4More
Imatinibhsa04730Long-term depression3.10E-034Q14344, P08069, P04049, P07948GNA13, IGF1R, RAF1, LYNMore
Imatinibhsa04740Olfactory transduction4.52E-054P62873, Q13557, P0DP23, P0DP24GNB1, CAMK2D, CALM1, CALM2More
Imatinibhsa04742Taste transduction1.18E-032P30939, P17612HTR1F, PRKACAMore
Imatinibhsa04744Phototransduction1.02E-083P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Imatinibhsa04750Inflammatory mediator regulation of TRP channels1.51E-1114P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Imatinibhsa04810Regulation of actin cytoskeleton1.78E-026Q13009, P04049, P11215, P16144, P60709, P01042TIAM1, RAF1, ITGAM, ITGB4, ACTB, KNG1More
Imatinibhsa04910Insulin signaling pathway2.43E-056P0DP23, P22694, P06737, P04049, P31751, P49841CALM1, PRKACB, PYGL, RAF1, AKT2, GSK3BMore
Imatinibhsa04911Insulin secretion2.66E-095Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Imatinibhsa04912GnRH signaling pathway5.74E-0813P17252, Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694, P04049, P45985PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM1, CALM2, PRKACB, RAF1, MAP2K4More
Imatinibhsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Imatinibhsa04914Progesterone-mediated oocyte maturation1.42E-096P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Imatinibhsa04915Estrogen signaling pathway1.30E-1112P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, P0DP24, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, CALM2, NCOA1More
Imatinibhsa04916Melanogenesis7.31E-044P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Imatinibhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Imatinibhsa04918Thyroid hormone synthesis2.03E-066Q08828, P51828, Q99941, P18848, P02768, P05543ADCY1, ADCY7, CREBL1, ATF4, ALB, SERPINA7More
Imatinibhsa04919Thyroid hormone signaling pathway3.02E-0611P49841, P19174, P04049, P42224, P22694, P60709, Q13547, O60244, Q9NVC6, Q9UM47, P01106GSK3B, PLCG1, RAF1, STAT1, PRKACB, ACTB, HDAC1, MED14, MED17, NOTCH3, MYCMore
Imatinibhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Imatinibhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Imatinibhsa04922Glucagon signaling pathway3.10E-047P14618, P06737, Q12778, P31751, Q13370, P0DP23, Q14643PKM2, PYGL, FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Imatinibhsa04923Regulation of lipolysis in adipocytes4.29E-077Q08828, P51828, P07550, P06213, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, INSR, PIK3CB, IRS2, AKT2More
Imatinibhsa04924Renin secretion8.24E-075P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Imatinibhsa04925Aldosterone synthesis and secretion1.65E-108Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, CAMK2D, ATP2B4More
Imatinibhsa04926Relaxin signaling pathway1.66E-0814P31751, P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P49767, Q08828, P51828, P04049, P30679, P49407AKT2, PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, GNA15, ARRB1More
Imatinibhsa04927Cortisol synthesis and secretion4.39E-074Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Imatinibhsa04928Parathyroid hormone synthesis, secretion and action3.95E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Imatinibhsa04929GnRH secretion6.93E-064P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Imatinibhsa04930Type II diabetes mellitus6.29E-053P06213, Q05655, Q02156INSR, PRKCD, PRKCEMore
Imatinibhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Imatinibhsa04932Non-alcoholic fatty liver disease1.13E-1716P31751, P01375, P49841, Q14790, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, P19404, O14521AKT2, TNF, GSK3B, CASP8, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHDMore
Imatinibhsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Imatinibhsa04934Cushing syndrome2.90E-096Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Imatinibhsa04935Growth hormone synthesis, secretion and action4.62E-057Q08828, P51828, P04049, Q99941, P18848, P31751, P45985ADCY1, ADCY7, RAF1, CREBL1, ATF4, AKT2, MAP2K4More
Imatinibhsa04940Type I diabetes mellitus7.38E-044P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Imatinibhsa04960Aldosterone-regulated sodium reabsorption7.59E-032O00141, P06213SGK, INSRMore
Imatinibhsa04962Vasopressin-regulated water reabsorption2.95E-043P52566, P62491, P46459ARHGDIB, RAB11A, NSFMore
Imatinibhsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Imatinibhsa04966Collecting duct acid secretion1.26E-043Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Imatinibhsa04970Salivary secretion2.10E-0910P07550, Q08828, P51828, P22694, Q14643, P23634, P0DP24, P0DP23, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, CALM2, CALM1, GUCY1B3, CAMPMore
Imatinibhsa04971Gastric acid secretion3.36E-076Q08828, P51828, P15311, P0DP24, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM2, CALM1, CAMK2DMore
Imatinibhsa04972Pancreatic secretion1.31E-022Q08828, P62491ADCY1, RAB11AMore
Imatinibhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Imatinibhsa04974Protein digestion and absorption1.22E-032Q7Z2H8, P02452SLC36A1, COL1A1More
Imatinibhsa04975Fat digestion and absorption4.83E-021O14494PLPP1More
Imatinibhsa04976Bile secretion8.33E-076O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Imatinibhsa04979Cholesterol metabolism1.37E-023P38571, P61916, P45880LIPA, NPC2, VDAC2More
Imatinibhsa05010Alzheimer disease1.77E-1027P49768, Q92542, O15239, Q16718, O95298, P19404, O14521, P05496, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P0DP24, P01584, Q12933, P18848, Q13509, P68371, O15169, P67870, P31751, P05141, Q08752, P28070, P43686PSEN1, NCSTN, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, CALM2, IL1B, TRAF2, ATF4, TUBB3, TUBB2C, AXIN1, CSNK2B, AKT2, SLC25A5, PPID, PSMB4, PSMC4More
Imatinibhsa05012Parkinson disease1.03E-0619O15239, Q16718, O95298, O14521, P13073, P12074, P05496, P05141, P12236, O75460, P18848, P28070, P43686, Q14643, P0DP23, P0DP24, Q13557, Q13509, P68371NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, COX6A1, ATP5G1, SLC25A5, SLC25A6, ERN1, ATF4, PSMB4, PSMC4, ITPR1, CALM1, CALM2, CAMK2D, TUBB3, TUBB2CMore
Imatinibhsa05014Amyotrophic lateral sclerosis4.18E-025P19404, P12074, O75460, P28070, Q8TEV9NDUFV2, COX6A1, ERN1, PSMB4, SMCR8More
Imatinibhsa05016Huntington disease3.16E-0813O15239, O95298, P19404, P13073, P12074, P24928, P30876, P62487, P05141, P45880, O75460, P28070, O00232NDUFA1, NDUFC2, NDUFV2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, VDAC2, ERN1, PSMB4, PSMD12More
Imatinibhsa05017Spinocerebellar ataxia1.88E-049Q92915, O75460, Q8TB72, O15399, P42338, P31751, P28070, P05141, P21796FGF14, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1More
Imatinibhsa05020Prion disease1.70E-0926P13591, P01584, P46531, P0DMV8, P11142, O15239, Q16718, O95298, O14521, P05496, P13073, P12074, Q14643, P18848, P05141, P12236, P28070, P43686, Q13509, P68371, P49841, P67870, Q99941, P14598, Q15080, Q16539NCAM1, IL1B, NOTCH1, HSPA1A, HSPA8, NDUFA1, NDUFA5, NDUFC2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, TUBB3, TUBB2C, GSK3B, CSNK2B, CREBL1, NCF1, NCF4, MAPK14More
Imatinibhsa05022Pathways of neurodegeneration - multiple diseases3.39E-1338Q14643, Q13509, P68371, P49841, P67870, P10415, O15239, Q16718, O95298, P19404, O14521, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, Q12933, Q13561, P05141, P45880, P17252, P20333, Q16539, Q15078, Q00535, O15169, P01584, P49768, Q08752, O15020, P0DP23, P0DP24, Q13557, P62987, P28070, P43686ITPR1, TUBB3, TUBB2C, GSK3B, CSNK2B, BCL2, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, TRAF2, DCTN2, SLC25A5, VDAC2, PRKCA, TNFRSF1B, MAPK14, CDK5R1, CDK5, AXIN1, IL1B, PSEN1, PPID, SPTBN2, CALM1, CALM2, CAMK2D, UBA52, PSMB4, PSMC4More
Imatinibhsa05030Cocaine addiction7.19E-043Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Imatinibhsa05031Amphetamine addiction8.44E-075P0DP24, P0DP23, Q13557, Q99941, P18848CALM2, CALM1, CAMK2D, CREBL1, ATF4More
Imatinibhsa05032Morphine addiction5.68E-032P78334, P32298GABRE, GRK4More
Imatinibhsa05033Nicotine addiction4.01E-021P78334GABREMore
Imatinibhsa05034Alcoholism1.22E-0816Q99941, P18848, Q13547, P0DP24, Q96RR4, P62873, P61952, P04049, P0C0S5, Q93077, P58876, P62807, Q16778, O60814, P84243, P68431CREBL1, ATF4, HDAC1, CALM2, CAMKK2, GNB1, GNG11, RAF1, H2AFZ, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Imatinibhsa05100Bacterial invasion of epithelial cells3.14E-033Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Imatinibhsa05110Vibrio cholerae infection1.86E-042Q99437, P17612ATP6V0B, PRKACAMore
Imatinibhsa05120Epithelial cell signaling in Helicobacter pylori infection3.72E-1311Q16539, Q99437, Q13153, P09341, P19875, P10145, P19174, P25024, P25025, P41240, P07948MAPK14, ATP6V0B, PAK1, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2, CSK, LYNMore
Imatinibhsa05130Pathogenic Escherichia coli infection2.72E-0411P16333, Q13509, P60709, P25963, P04406, P29350, Q06124, Q15438, P35579, P55061, O95487NCK1, TUBB3, ACTB, NFKBIA, GAPDH, PTPN6, PTPN11, PSCD1, MYH9, TEGT, SEC24BMore
Imatinibhsa05131Shigellosis3.55E-0618Q12933, Q13546, P68431, Q05655, Q02156, Q9UDY8, Q9NQL2, P0CG47, Q14141, Q14247, Q96JJ3, Q05397, Q14643, Q12778, Q13315, P10415, Q08752, P07737TRAF2, RIPK1, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCE, MALT1, RRAGD, UBB, SEPT6, CTTN, ELMO2, PTK2, ITPR1, FOXO1, ATM, BCL2, PPID, PFN1More
Imatinibhsa05132Salmonella infection1.26E-0920P51617, P25963, P08238, P04049, Q9UJU2, P01106, P84095, P60709, Q13546, Q13489, P10415, P04406, O75369, P07737, O60603, Q9BQS8, Q13561, Q13509, P68371, P49754IRAK1, NFKBIA, HSP90AB1, RAF1, LEF1, MYC, RHOG, ACTB, RIPK1, BIRC3, BCL2, GAPDH, FLNB, PFN1, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C, VPS41More
Imatinibhsa05133Pertussis1.55E-063P05107, P10145, P0C0L4ITGB2, IL8, C4AMore
Imatinibhsa05134Legionellosis6.43E-119P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Imatinibhsa05135Yersinia infection1.86E-048Q05397, P51812, P06239, P19174, Q02750, P42338, Q96JJ3, P01732PTK2, RPS6KA3, LCK, PLCG1, MAP2K1, PIK3CB, ELMO2, CD8AMore
Imatinibhsa05140Leishmaniasis2.26E-0915P13612, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, NCF4More
Imatinibhsa05142Chagas disease2.70E-022P48023, Q14790FASLG, CASP8More
Imatinibhsa05143African trypanosomiasis5.79E-064P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Imatinibhsa05144Malaria8.71E-0810P60033, P69905, P68871, O60603, P01375, P05107, P35443, P01584, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL1B, IL8, KLRK1More
Imatinibhsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Imatinibhsa05146Amoebiasis1.48E-1913P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Imatinibhsa05150Staphylococcus aureus infection8.75E-1015P09871, P0C0L4, P21730, P21462, O75015, P31995, P13765, P13646, Q14532, P05107, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, FCGR2C, HLA-DOB, KRT13, KRT32, ITGB2, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Imatinibhsa05152Tuberculosis4.74E-0714P04049, Q13488, Q99437, P0DP23, P42224, P48382, O60603, P31751, P10415, P13765, P25774, P01568, Q9UDY8, P51617RAF1, TCIRG1, ATP6V0B, CALM1, STAT1, RFX5, TLR2, AKT2, BCL2, HLA-DOB, CTSS, IFNA21, MALT1, IRAK1More
Imatinibhsa05160Hepatitis C1.84E-059Q13546, P01568, P52630, P60033, Q9NZJ5, P04049, P49841, P01375, P48023RIPK1, IFNA21, STAT2, CD81, EIF2AK3, RAF1, GSK3B, TNF, FASLGMore
Imatinibhsa05161Hepatitis B4.11E-044P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Imatinibhsa05162Measles6.91E-057P23458, P31751, P0DMV8, P11142, P01584, P67870, Q9NP90JAK1, AKT2, HSPA1A, HSPA8, IL1B, CSNK2B, RAB9BMore
Imatinibhsa05163Human cytomegalovirus infection1.17E-1127P31751, P04049, P01375, P62873, P63218, P50151, P61952, Q14643, P0DP23, P0DP24, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P30101, P61769AKT2, RAF1, TNF, GNB1, GNG5, GNG10, GNG11, ITPR1, CALM1, CALM2, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, PDIA3, B2MMore
Imatinibhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Imatinibhsa05165Human papillomavirus infection7.06E-0517P16144, P02452, P24821, Q16363, Q05086, P30281, Q9UM47, P01568, P42224, P01889, P10321, Q13488, Q99437, Q13362, Q12778, P04628, Q13315ITGB4, COL1A1, TNC, LAMA4, UBE3A, CCND3, NOTCH3, IFNA21, STAT1, HLA-B, HLA-C, TCIRG1, ATP6V0B, PPP2R5C, FOXO1, WNT1, ATMMore
Imatinibhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Imatinibhsa05167Kaposi sarcoma-associated herpesvirus infection6.03E-0615P01568, P31751, P42224, P25963, P62873, P62879, P19174, P16298, Q14643, P04049, Q02750, P01106, P0DP23, P0CG47, Q9UJU2IFNA21, AKT2, STAT1, NFKBIA, GNB1, GNB2, PLCG1, PPP3CB, ITPR1, RAF1, MAP2K1, MYC, CALM1, UBB, LEF1More
Imatinibhsa05168Herpes simplex virus 1 infection4.64E-0317O00463, O60603, P25963, Q05823, Q07955, Q01130, Q16629, Q9Y2A4, P51522, Q9NR11, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415TRAF5, TLR2, NFKBIA, RNASEL, SFRS1, SFRS2, SFRS7, ZNF443, ZNF83, ZNF302, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Imatinibhsa05169Epstein-Barr virus infection6.88E-0817P13765, P01106, Q13547, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, P42224, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, STAT1, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Imatinibhsa05170Human immunodeficiency virus 1 infection3.94E-1118P31751, P04049, Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q14643, P01568, P51617, O60603, Q13315, P23528, P10415, Q9Y6Q5, P20333AKT2, RAF1, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, ITPR1, IFNA21, IRAK1, TLR2, ATM, CFL1, BCL2, AP1M2, TNFRSF1BMore
Imatinibhsa05171Coronavirus disease - COVID-192.21E-1221P01584, P23396, P62753, P25398, P42677, P36578, Q02878, P62917, P32969, P27635, P26373, Q07020, P62888, P46776, P62899, P62910, P18077, P61927, P61513, P05386, P62829IL1B, RPS3, RPS6, RPS12, RPS27, RPL4, RPL6, RPL8, RPL9, RPL10, RPL13, RPL18, RPL30, RPL27A, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPLP1, RPL23More
Imatinibhsa05200Pathways in cancer9.39E-0730P08238, P42224, P25963, P19174, P01106, Q9UJU2, P17252, P43246, Q13485, P20585, P52701, P14923, P30279, P10415, Q13489, Q13077, P49767, P14921, Q12778, P31751, P25116, P62873, P63218, Q9UM47, P78417, O75293, P0DP23, P01568, P14784, P01042HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, LEF1, PRKCA, MSH2, SMAD4, MSH3, MSH6, JUP, CCND2, BCL2, BIRC3, TRAF1, VEGFC, ETS1, FOXO1, AKT2, F2R, GNB1, GNG5, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1More
Imatinibhsa05202Transcriptional misregulation in cancer6.48E-1330Q12778, Q15532, P01106, Q13315, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, P11215, Q13077, O15550, P08069, P46527, P35226, O60583, P05164, P59665, P59666, P12838, P08246, P42773, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, MYC, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, ITGAM, TRAF1, UTX, IGF1R, CDKN1B, BMI1, CCNT2, MPO, DEFA1; DEFA1B, DEFA3, DEFA4, ELA2, CDKN2C, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Imatinibhsa05203Viral carcinogenesis2.40E-0817Q12933, Q99941, P18848, P30281, P27348, Q13547, Q15283, P06396, P12814, P01889, P10321, P61978, P06493, P58876, P62807, Q16778, O60814TRAF2, CREBL1, ATF4, CCND3, YWHAQ, HDAC1, RASA2, GSN, ACTN1, HLA-B, HLA-C, HNRPK, CDK1, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Imatinibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Imatinibhsa05205Proteoglycans in cancer6.79E-0510Q13009, Q12955, O75369, P60709, P04049, P01106, P08069, P19174, P29350, P08962TIAM1, ANK3, FLNB, ACTB, RAF1, MYC, IGF1R, PLCG1, PTPN6, CD63More
Imatinibhsa05206MicroRNAs in cancer8.54E-034P16070, Q13315, P04049, Q02750CD44, ATM, RAF1, MAP2K1More
Imatinibhsa05210Colorectal cancer1.47E-049Q9UKG1, Q13485, P43246, P04049, P01106, P52701, P20585, P37173, O75293APPL1, SMAD4, MSH2, RAF1, MYC, MSH6, MSH3, TGFBR2, GADD45BMore
Imatinibhsa05211Renal cell carcinoma6.14E-064Q06124, Q13153, P31751, P04049PTPN11, PAK1, AKT2, RAF1More
Imatinibhsa05212Pancreatic cancer5.93E-044P31751, P04049, Q15311, P23458AKT2, RAF1, RALBP1, JAK1More
Imatinibhsa05213Endometrial cancer4.41E-044O15169, P31751, Q02750, P04049AXIN1, AKT2, MAP2K1, RAF1More
Imatinibhsa05214Glioma6.68E-066P08069, P0DP23, P04049, P31751, P19174, O75293IGF1R, CALM1, RAF1, AKT2, PLCG1, GADD45BMore
Imatinibhsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Imatinibhsa05217Basal cell carcinoma7.91E-035Q13635, P04628, P49841, Q9UJU2, P24522PTCH1, WNT1, GSK3B, LEF1, GADD45AMore
Imatinibhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Imatinibhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Imatinibhsa05220Chronic myeloid leukemia4.54E-045P01106, P25963, P46527, P31751, P04049MYC, NFKBIA, CDKN1B, AKT2, RAF1More
Imatinibhsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Imatinibhsa05222Small cell lung cancer4.78E-021P31751AKT2More
Imatinibhsa05223Non-small cell lung cancer3.49E-042P31751, P04049AKT2, RAF1More
Imatinibhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Imatinibhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Imatinibhsa05226Gastric cancer3.48E-044P04049, Q02750, P31751, O15169RAF1, MAP2K1, AKT2, AXIN1More
Imatinibhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Imatinibhsa05231Choline metabolism in cancer2.51E-069P04049, P31751, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494RAF1, AKT2, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1More
Imatinibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.09E-1718P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P23458, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, JAK1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Imatinibhsa05310Asthma1.21E-093P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Imatinibhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Imatinibhsa05321Inflammatory bowel disease4.09E-1710O60603, P01375, P28068, P13765, Q14765, Q9UL17, P42226, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DMB, HLA-DOB, STAT4, TBX21, STAT6, GATA3, IL1B, IL21RMore
Imatinibhsa05322Systemic lupus erythematosus1.83E-1018P08637, O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P14678, P12814FCGR3A, FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SNRPB, ACTN1More
Imatinibhsa05323Rheumatoid arthritis7.52E-068P01375, Q06643, P13765, Q13488, P10747, P09341, P19875, O60603TNF, LTB, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2More
Imatinibhsa05330Allograft rejection7.88E-055P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Imatinibhsa05332Graft-versus-host disease9.84E-146P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Imatinibhsa05340Primary immunodeficiency4.07E-056P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Imatinibhsa05410Hypertrophic cardiomyopathy1.24E-032P26012, P09493ITGB8, TPM1More
Imatinibhsa05412Arrhythmogenic right ventricular cardiomyopathy2.97E-053P54284, P15924, P26012CACNB3, DSP, ITGB8More
Imatinibhsa05414Dilated cardiomyopathy3.78E-034P54284, P26012, P09493, P26678CACNB3, ITGB8, TPM1, PLNMore
Imatinibhsa05415Diabetic cardiomyopathy2.62E-0614P17252, P30405, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557, P14780, P37173PRKCA, PPIF, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2D, MMP9, TGFBR2More
Imatinibhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Imatinibhsa05418Fluid shear stress and atherosclerosis1.27E-0510Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Imatinib (SDC: 12.83)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09619PDGFRBPlateletNonederived growth factor receptor betaReported00.04960.94440.74082.6543
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
O14976GAKCyclinNoneGNoneassociated kinasePredicted10.57280.256200.7989
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
Q9Y6R4MAP3K4MitogenNoneactivated protein kinase kinase kinase 4Predicted00.35280.24520.1730.8399
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
Q9H422HIPK3HomeodomainNoneinteracting protein kinase 3Predicted00.3650.25080.2180.902
O94806PRKD3Serine/threonineNoneprotein kinase D3Predicted00.23120.24340.16920.7715
Q00536PCTK1CyclinNonedependent kinase 16Predicted00.27140.25600.6478
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q16513PKN2Serine/threonineNoneprotein kinase N2Predicted00.04210.27780.33910.9157
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q9UEW8STK39STE20/SPS1Nonerelated prolineNonealanineNonerich protein kinasePredicted00.25730.245200.6191
Q96BR1SGK3Serine/threonineNoneprotein kinase Sgk3Predicted00.0260.26840.31140.8612
P49760CLK2Dual specificity protein kinase CLK2Predicted00.03030.295100.6053
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
O95835LATS1Serine/threonineNoneprotein kinase LATS1Predicted00.43320.24520.02170.7288
O43283MAP3K13MitogenNoneactivated protein kinase kinase kinase 13Predicted00.45650.24520.14870.8674
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
O95747OXSR1Serine/threonineNoneprotein kinase OSR1Predicted00.18390.245200.5825
Q9H2K8TAOK3Serine/threonineNoneprotein kinase TAO3Predicted00.06460.24520.14870.6715
Q9P289STK26Serine/threonineNoneprotein kinase 26Predicted10.02850.262800.5399
Q9NQU5PAK6Serine/threonineNoneprotein kinase PAK 6Predicted00.4090.26690.50031.2386
Q8NI60CABC1Atypical kinase COQ8A, mitochondrialPredicted00.62760.245200.8043
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
Q86Z02HIPK1HomeodomainNoneinteracting protein kinase 1Predicted00.46310.28160.2181.0128
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P32298GRK4G proteinNonecoupled receptor kinase 4Predicted00.03520.23860.29480.7896
Q9Y6E0STK24Serine/threonineNoneprotein kinase 24Predicted00.54580.245200.7634
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
Q8IVH8MAP4K3MitogenNoneactivated protein kinase kinase kinase kinase 3Predicted00.38330.26730.14870.875
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
Q13523PRPF4BSerine/threonineNoneprotein kinase PRP4 homologPredicted00.13760.245200.5593
Q15831STK11Serine/threonineNoneprotein kinase STK11Predicted00.15110.24410.45491.0186
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
Q8IVW4CDKL3CyclinNonedependent kinaseNonelike 3Predicted00.41490.241600.6906
Q13873BMPR2Bone morphogenetic protein receptor typeNone2Predicted10.34760.24520.35481.019
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
O75460ERN1Serine/threonineNoneprotein kinase/endoribonuclease IRE1Predicted10.68060.29440.5571.4862
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
Q16566CAMK4Calcium/calmodulinNonedependent protein kinase type IVPredicted00.07180.24410.61761.1417
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
P07332FESTyrosineNoneprotein kinase Fes/FpsPredicted00.27220.26280.15130.8131
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q99759MAP3K3MitogenNoneactivated protein kinase kinase kinase 3Predicted00.35450.24520.43781.1055
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P45985MAP2K4Dual specificity mitogenNoneactivated protein kinase kinase 4Predicted00.42480.24730.74031.4474
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P42226STAT6Signal transducer and activator of transcription 6Predicted00.31610.03530.5090.7378
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
Q8TCT0CERKCeramide kinasePredicted00.24120.00560.09570.2274
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q9NZJ5EIF2AK3Eukaryotic translation initiation factor 2Nonealpha kinase 3Predicted10.09390.15740.63981.0015
Q15046KARSLysineNoneNonetRNA ligasePredicted00.10330.0580.00270.1702
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q15743GPR68Ovarian cancer GNoneprotein coupled receptor 1Predicted00.06580.013700.0602
P53609PGGT1BGeranylgeranyl transferase typeNone1 subunit betaPredicted00.04990.02700.0789
P20292ALOX5APArachidonate 5NonelipoxygenaseNoneactivating proteinPredicted00.13030.24180.09070.6395
O75381PEX14Peroxisomal membrane protein PEX14Predicted00.19070.09950.10970.4039
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
O60880SH2D1ASH2 domainNonecontaining protein 1APredicted00.03520.01650.18070.2313
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
PDGFRBP09619IC5050
PDGFRBP09619IC5072
PDGFRBP09619IC50240
PDGFRBP09619Ki3
PDGFRBP09619Kd14
PDGFRBP09619Kd28