PharmaCoNets

PharmaCoNets of Iloprost (S_PCN: 14.50 )

Iloprost regulated-network (S_DN: 11.69)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Iloprost

hsa00030

Pentose phosphate pathway

5.07E-03

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Iloprost

hsa00220

Arginine biosynthesis

1.54E-02

P05089, P49448

ARG1, GLUD2

Iloprost

hsa00310

Lysine degradation

6.96E-03

Q96KQ7, P51648

EHMT2, ALDH3A2

Iloprost

hsa00500

Starch and sucrose metabolism

3.86E-02

O43451, P46976, P06737

MGAM, GYG1, PYGL

Iloprost

hsa00515

Mannose type O-glycan biosynthesis

4.96E-02

O75072

FCMD

Iloprost

hsa00620

Pyruvate metabolism

2.18E-02

P40925, P51648

MDH1, ALDH3A2

Iloprost

hsa00630

Glyoxylate and dicarboxylate metabolism

4.32E-05

P40925, P15104

MDH1, GLUL

Iloprost

hsa00910

Nitrogen metabolism

2.93E-02

P22748, P49448

CA4, GLUD2

Iloprost

hsa00970

Aminoacyl-tRNA biosynthesis

5.32E-03

O95363, P54136, Q15046

FARS2, RARS1, KARS

Iloprost

hsa00983

Drug metabolism - other enzymes

2.16E-03

P04183, P32320, P05164

TK1, CDA, MPO

Iloprost

hsa01524

Platinum drug resistance

1.13E-02

P10415, Q13489, P78417, P23025, P43246

BCL2, BIRC3, GSTO1, XPA, MSH2

Iloprost

hsa03008

Ribosome biogenesis in eukaryotes

2.52E-02

P78345, O15381, Q9GZY0

RPP38, NVL, NXF2; NXF2B

Iloprost

hsa03013

RNA transport

7.27E-03

O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, Q14240, Q9Y6A5, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, EIF4A2, TACC3, FXR1

Iloprost

hsa03040

Spliceosome

3.37E-05

Q14562, O43143, O60508, Q99633, P26368, Q13595, Q01130, Q13243, Q9UMS4, P11142, O43447

DHX8, DHX15, CDC40, PRPF18, U2AF2, TRA2A, SFRS2, SFRS5, PRPF19, HSPA8, PPIH

Iloprost

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Iloprost

hsa03450

Non-homologous end-joining

4.96E-02

Q9NP87

POLM

Iloprost

hsa04015

Rap1 signaling pathway

1.58E-02

P20827, P49767, P63261, P25116, P0DP23, P17252

EFNA1, VEGFC, ACTG1, F2R, CALM1, PRKCA

Iloprost

hsa04020

Calcium signaling pathway

1.16E-03

Q16566, P17252, O15399, P25116, P0DP23, P23634, P49767

CAMK4, PRKCA, GRIN2D, F2R, CALM1, ATP2B4, VEGFC

Iloprost

hsa04024

cAMP signaling pathway

2.84E-02

P0DP23, P23634, Q16566, O15399, P25116

CALM1, ATP2B4, CAMK4, GRIN2D, F2R

Iloprost

hsa04060

Cytokine-cytokine receptor interaction

1.74E-04

P14784, P27930, P14778, P08476, P26842, Q06643, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, P01375, P09341, P19875, P18510, P01730, Q93038

IL2RB, IL1R2, IL1R1, INHBA, CD27, LTB, IL10RA, IL21R, CXCR1, XCL2, XCL1, TNF, CXCL1, CXCL2, IL1RN, CD4, TNFRSF25

Iloprost

hsa04061

Viral protein interaction with cytokine and cytokine receptor

3.36E-04

P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNF

Iloprost

hsa04062

Chemokine signaling pathway

5.37E-03

P25024, P09341, P19875, P07948, P42338, P19174, P63218, P50151, P43250

CXCR1, CXCL1, CXCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6

Iloprost

hsa04064

NF-kappa B signaling pathway

3.72E-06

P10415, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q16548, P07948, P06239, Q13315, P24522, O75293, P09341, P19875, Q06643

BCL2, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, BCL2A1, LYN, LCK, ATM, GADD45A, GADD45B, CXCL1, CXCL2, LTB

Iloprost

hsa04071

Sphingolipid signaling pathway

3.20E-05

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Iloprost

hsa04080

Neuroactive ligand-receptor interaction

6.23E-03

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1

Iloprost

hsa04141

Protein processing in endoplasmic reticulum

1.41E-02

P30101, P60604, P11142, P08238

PDIA3, UBE2G2, HSPA8, HSP90AB1

Iloprost

hsa04145

Phagosome

7.94E-05

O75015, P63261, Q15080, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P27824, P13765

FCGR3B, ACTG1, NCF4, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, CANX, HLA-DOB

Iloprost

hsa04210

Apoptosis

2.59E-02

P10415, O76075, P01375, P24522, Q16548, P43234, P18848, Q14643

BCL2, DFFB, TNF, GADD45A, BCL2A1, CTSO, ATF4, ITPR1

Iloprost

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Iloprost

hsa04340

Hedgehog signaling pathway

4.63E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Iloprost

hsa04350

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Iloprost

hsa04390

Hippo signaling pathway

1.47E-02

P63261, Q13485, Q9UJU2, O43623, Q13489

ACTG1, SMAD4, LEF1, SNAI2, BIRC3

Iloprost

hsa04510

Focal adhesion

3.21E-02

Q15942, P17252, Q13489, P10415, P49767, P63261

ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1

Iloprost

hsa04520

Adherens junction

3.36E-02

Q13485, Q9UJU2, O43623, P63261

SMAD4, LEF1, SNAI2, ACTG1

Iloprost

hsa04540

Gap junction

4.76E-02

P17252, Q13509, P68371

PRKCA, TUBB3, TUBB2C

Iloprost

hsa04612

Antigen processing and presentation

7.95E-06

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Iloprost

hsa04613

Neutrophil extracellular trap formation

6.03E-04

P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Iloprost

hsa04614

Renin-angiotensin system

1.52E-02

P50052

AGTR2

Iloprost

hsa04640

Hematopoietic cell lineage

2.66E-04

P13612, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF

Iloprost

hsa04650

Natural killer cell mediated cytotoxicity

7.60E-07

P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O75015, P26717, P26715

PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P24158	PRTN3	Myeloblastin	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.816
P51124	GZMM	Granzyme M	O60880	SH2D1A	SH2 domain-containing protein 1A	0.743
P49863	GZMK	Granzyme K	O60880	SH2D1A	SH2 domain-containing protein 1A	0.899
P08311	CTSG	Cathepsin G	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.92
P24158	PRTN3	Myeloblastin	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.729
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
P24158	PRTN3	Myeloblastin	Q13241	KLRD1	Natural killer cells antigen CD94	-0.732
P49863	GZMK	Granzyme K	Q13241	KLRD1	Natural killer cells antigen CD94	0.809
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P24158	PRTN3	Myeloblastin	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.76
P51124	GZMM	Granzyme M	P26718	KLRK1	NKG2-D type II integral membrane protein	0.713
P49863	GZMK	Granzyme K	P26718	KLRK1	NKG2-D type II integral membrane protein	0.96
P08311	CTSG	Cathepsin G	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.875
P49863	GZMK	Granzyme K	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.775
P24158	PRTN3	Myeloblastin	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.77
P49863	GZMK	Granzyme K	P26717	KLRC2	NKG2-C type II integral membrane protein	0.891
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P24158	PRTN3	Myeloblastin	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
P49863	GZMK	Granzyme K	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.891
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867

Iloprost

hsa04657

IL-17 signaling pathway

8.05E-04

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Iloprost

hsa04658

Th1 and Th2 cell differentiation

1.80E-10

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49863	GZMK	Granzyme K	Q04759	PRKCQ	Protein kinase C theta type	0.874
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P49863	GZMK	Granzyme K	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.756
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P49863	GZMK	Granzyme K	Q14765	STAT4	Signal transducer and activator of transcription 4	0.848
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P49863	GZMK	Granzyme K	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.768
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P51124	GZMM	Granzyme M	Q9UL17	TBX21	T-box transcription factor TBX21	0.755
P49863	GZMK	Granzyme K	Q9UL17	TBX21	T-box transcription factor TBX21	0.918
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P51124	GZMM	Granzyme M	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.887
P49863	GZMK	Granzyme K	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.882
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P51124	GZMM	Granzyme M	Q13761	RUNX3	Runt-related transcription factor 3	0.849
P49863	GZMK	Granzyme K	Q13761	RUNX3	Runt-related transcription factor 3	0.704

Iloprost

hsa04659

Th17 cell differentiation

9.49E-08

Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49863	GZMK	Granzyme K	Q04759	PRKCQ	Protein kinase C theta type	0.874
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P49863	GZMK	Granzyme K	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.756
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P51124	GZMM	Granzyme M	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.887
P49863	GZMK	Granzyme K	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.882
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P51124	GZMM	Granzyme M	P14778	IL1R1	Interleukin-1 receptor type 1	-0.886
P49863	GZMK	Granzyme K	Q9HBE5	IL21R	Interleukin-21 receptor	0.722
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763
P51124	GZMM	Granzyme M	Q9UL17	TBX21	T-box transcription factor TBX21	0.755
P49863	GZMK	Granzyme K	Q9UL17	TBX21	T-box transcription factor TBX21	0.918
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P49863	GZMK	Granzyme K	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.768
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888

Iloprost

hsa04660

T cell receptor signaling pathway

3.88E-07

P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49863	GZMK	Granzyme K	P01375	TNF	Tumor necrosis factor	-0.8
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P49863	GZMK	Granzyme K	Q04759	PRKCQ	Protein kinase C theta type	0.874
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P51124	GZMM	Granzyme M	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.834
P49863	GZMK	Granzyme K	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.872
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
P49863	GZMK	Granzyme K	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.952
P08311	CTSG	Cathepsin G	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P51124	GZMM	Granzyme M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.783
P51124	GZMM	Granzyme M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.916
P49863	GZMK	Granzyme K	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.745
P51124	GZMM	Granzyme M	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.824
P49863	GZMK	Granzyme K	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.893
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P49863	GZMK	Granzyme K	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.786
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P51124	GZMM	Granzyme M	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P49863	GZMK	Granzyme K	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.784
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P49863	GZMK	Granzyme K	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.793
P51124	GZMM	Granzyme M	P06239	LCK	Tyrosine-protein kinase Lck	0.862
P49863	GZMK	Granzyme K	P06239	LCK	Tyrosine-protein kinase Lck	0.846
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P49863	GZMK	Granzyme K	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.756
P49863	GZMK	Granzyme K	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.716

Iloprost

hsa04662

B cell receptor signaling pathway

1.07E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Iloprost

hsa04664

Fc epsilon RI signaling pathway

1.29E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Iloprost

hsa04668

TNF signaling pathway

3.19E-02

P01375, O00463, Q16539, P09341, P20749, Q13077, P14780

TNF, TRAF5, MAPK14, CXCL1, BCL3, TRAF1, MMP9

Iloprost

hsa04720

Long-term potentiation

2.74E-03

P17252, Q16566, P0DP23, O15399

PRKCA, CAMK4, CALM1, GRIN2D

Iloprost

hsa04723

Retrograde endocannabinoid signaling

1.75E-02

Q14643, P17252, P22694, Q16539, Q16718

ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5

Iloprost

hsa04724

Glutamatergic synapse

2.81E-02

P43003, P63218, P50151, P15104

SLC1A3, GNG5, GNG10, GLUL

Iloprost

hsa04725

Cholinergic synapse

3.86E-02

P22694, Q14643, P18848, P10415

PRKACB, ITPR1, ATF4, BCL2

Iloprost

hsa04730

Long-term depression

1.35E-02

Q14344, P07948

GNA13, LYN

Iloprost

hsa04750

Inflammatory mediator regulation of TRP channels

4.06E-03

P14778, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759

IL1R1, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ

Iloprost

hsa04912

GnRH signaling pathway

3.14E-03

P17252, Q16539, Q9Y6R4, Q14643, P22694

PRKCA, MAPK14, MAP3K4, ITPR1, PRKACB

Iloprost

hsa04915

Estrogen signaling pathway

2.25E-02

P14780, P22694, P18848, Q14643, P10415

MMP9, PRKACB, ATF4, ITPR1, BCL2

Iloprost

hsa04916

Melanogenesis

3.55E-02

P0DP23, Q9UJU2, P17252

CALM1, LEF1, PRKCA

Iloprost

hsa04918

Thyroid hormone synthesis

2.91E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Iloprost

hsa04921

Oxytocin signaling pathway

4.19E-02

P0DP23, P17252, Q16566, P63261

CALM1, PRKCA, CAMK4, ACTG1

Iloprost

hsa04925

Aldosterone synthesis and secretion

7.20E-03

P0DP23, P17252, Q16566, P23634

CALM1, PRKCA, CAMK4, ATP2B4

Iloprost

hsa04927

Cortisol synthesis and secretion

7.04E-03

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Iloprost

hsa04928

Parathyroid hormone synthesis, secretion and action

1.65E-03

Q14643, P22694, P23771, P17252, P18848, P10415

ITPR1, PRKACB, GATA3, PRKCA, ATF4, BCL2

Iloprost

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.36E-02

Q13485, P10415, P49767, P17252

SMAD4, BCL2, VEGFC, PRKCA

Iloprost

hsa04934

Cushing syndrome

4.06E-02

Q14643, P22694, P49841, Q9UJU2, O00170

ITPR1, PRKACB, GSK3B, LEF1, AIP

Iloprost

hsa04964

Proximal tubule bicarbonate reclamation

2.93E-02

P22748, P49448

CA4, GLUD2

Iloprost

hsa04970

Salivary secretion

3.55E-02

P23634, P17252, P0DP23

ATP2B4, PRKCA, CALM1

Iloprost

hsa04971

Gastric acid secretion

4.76E-02

P17252, P63261, P0DP23

PRKCA, ACTG1, CALM1

Iloprost

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Iloprost

hsa04978

Mineral absorption

3.94E-02

P23634, Q9BXS9

ATP2B4, SLC26A6

Iloprost

hsa05012

Parkinson disease

2.31E-02

P21796, P60604, Q71U36, Q13509

VDAC1, UBE2G2, TUBA1A, TUBB3

Iloprost

hsa05014

Amyotrophic lateral sclerosis

4.31E-02

O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0

GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2B

Iloprost

hsa05020

Prion disease

3.50E-02

P11142, P21796, Q71U36, Q13509

HSPA8, VDAC1, TUBA1A, TUBB3

Iloprost

hsa05022

Pathways of neurodegeneration - multiple diseases

4.20E-02

Q71U36, Q13509, P21796, P04628, P60604

TUBA1A, TUBB3, VDAC1, WNT1, UBE2G2

Iloprost

hsa05031

Amphetamine addiction

1.49E-02

O15399, P0DP23, Q16566, P17252

GRIN2D, CALM1, CAMK4, PRKCA

Iloprost

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.78E-03

P09341, P19875, P19174, P25024, P07948

CXCL1, CXCL2, PLCG1, CXCR1, LYN

Iloprost

hsa05132

Salmonella infection

4.98E-02

Q9UJU2, P63261, Q13489, P10415, Q13509, P68371

LEF1, ACTG1, BIRC3, BCL2, TUBB3, TUBB2C

Iloprost

hsa05133

Pertussis

2.52E-02

P0DP23, P23528, P09871

CALM1, CFL1, C1S

Iloprost

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Iloprost

hsa05135

Yersinia infection

4.26E-02

P13612, P06239, Q16539, P01375, P49841, P01732

ITGA4, LCK, MAPK14, TNF, GSK3B, CD8A

Iloprost

hsa05144

Malaria

1.80E-02

O60603, P01375, P35443, P26718

TLR2, TNF, THBS4, KLRK1

Iloprost

hsa05146

Amoebiasis

1.05E-08

Q13751, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

LAMB3, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Iloprost

hsa05152

Tuberculosis

1.77E-03

Q13488, O75015, P48382, O60603, P01375, P10415, P13765, Q9UDY8, Q16539

TCIRG1, FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, MALT1, MAPK14

Iloprost

hsa05163

Human cytomegalovirus infection

2.64E-02

P42338, P63218, P50151, P01106, P14778, Q13651, P30101

PIK3CB, GNG5, GNG10, MYC, IL1R1, IL10RA, PDIA3

Iloprost

hsa05167

Kaposi sarcoma-associated herpesvirus infection

7.60E-03

P42338, P63218, P50151, P09341, P19875, P19174, P07948, P01106

PIK3CB, GNG5, GNG10, CXCL1, CXCL2, PLCG1, LYN, MYC

Iloprost

hsa05168

Herpes simplex virus 1 infection

1.94E-02

Q9UKJ0, P01568, Q9GZY0, Q01130, Q13489, Q13398, Q03923, Q9UDV6, P10415

PILRB, IFNA21, NXF2; NXF2B, SFRS2, BIRC3, ZNF211, ZNF85, ZNF212, BCL2

Iloprost

hsa05169

Epstein-Barr virus infection

1.27E-02

P01106, Q13547, P42338, P07948, P30101, Q13761, O75293, P07766, P20963

MYC, HDAC1, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, CD3E, CD247

Iloprost

hsa05170

Human immunodeficiency virus 1 infection

3.15E-02

P42338, P63218, P50151, P30101, P01730, P19174, P07766, P20963

PIK3CB, GNG5, GNG10, PDIA3, CD4, PLCG1, CD3E, CD247

Iloprost

hsa05200

Pathways in cancer

1.51E-02

Q9UJU2, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P25116, P78417, P0DP23, P01568

LEF1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, F2R, GSTO1, CALM1, IFNA21

Iloprost

hsa05202

Transcriptional misregulation in cancer

3.38E-06

Q12778, Q15532, Q13315, P41732, P14780, P27930, Q15744, Q16548, Q13489, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522

FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, BIRC3, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	Q12778	FOXO1	Forkhead box protein O1	-0.769
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15532	SS18	Protein SSXT	-0.803
P24158	PRTN3	Myeloblastin	Q15532	SS18	Protein SSXT	-0.732
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
Q15722	LTB4R	Leukotriene B4 receptor 1	P41732	TSPAN7	Tetraspanin-7	0.775
Q15722	LTB4R	Leukotriene B4 receptor 1	P14780	MMP9	Matrix metalloproteinase-9	0.861
P24158	PRTN3	Myeloblastin	P14780	MMP9	Matrix metalloproteinase-9	0.837
P08311	CTSG	Cathepsin G	P14780	MMP9	Matrix metalloproteinase-9	0.79
Q15722	LTB4R	Leukotriene B4 receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.734
P24158	PRTN3	Myeloblastin	P27930	IL1R2	Interleukin-1 receptor type 2	0.735
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P24158	PRTN3	Myeloblastin	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.741
P08311	CTSG	Cathepsin G	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.909
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16548	BCL2A1	Bcl-2-related protein A1	0.837
P24158	PRTN3	Myeloblastin	Q16548	BCL2A1	Bcl-2-related protein A1	0.802
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.797
Q15722	LTB4R	Leukotriene B4 receptor 1	O15550	UTX	Lysine-specific demethylase 6A	0.789
P24158	PRTN3	Myeloblastin	O15550	UTX	Lysine-specific demethylase 6A	0.776
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P24158	PRTN3	Myeloblastin	P05164	MPO	Myeloperoxidase	0.979
P08311	CTSG	Cathepsin G	P05164	MPO	Myeloperoxidase	0.956
P08311	CTSG	Cathepsin G	P12838	DEFA4	Neutrophil defensin 4	0.817
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P24158	PRTN3	Myeloblastin	P08246	ELA2	Neutrophil elastase	0.894
P08311	CTSG	Cathepsin G	P08246	ELA2	Neutrophil elastase	0.792
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.808
P24158	PRTN3	Myeloblastin	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.777
P08311	CTSG	Cathepsin G	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.853
Q15722	LTB4R	Leukotriene B4 receptor 1	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.764
P24158	PRTN3	Myeloblastin	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.772
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799