PharmaCoNets

PharmaCoNets of Iloperidone (S_PCN: 152.82 )

Iloperidone regulated-network (S_DN: 20.54)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Iloperidone

hsa00030

Pentose phosphate pathway

1.08E-05

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Iloperidone

hsa00052

Galactose metabolism

1.06E-03

P06280, O43451

GLA, MGAM

Iloperidone

hsa00120

Primary bile acid biosynthesis

3.72E-02

P22680, P22307

CYP7A1, SCP2

Iloperidone

hsa00190

Oxidative phosphorylation

1.28E-05

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Iloperidone

hsa00280

Valine, leucine and isoleucine degradation

3.41E-03

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Iloperidone

hsa00310

Lysine degradation

4.14E-02

Q02809

PLOD1

Iloperidone

hsa00500

Starch and sucrose metabolism

2.32E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Iloperidone

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Iloperidone

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Iloperidone

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Iloperidone

hsa00630

Glyoxylate and dicarboxylate metabolism

6.94E-03

P40925, P15104

MDH1, GLUL

Iloperidone

hsa00730

Thiamine metabolism

2.53E-04

P05186, P24666

ALPL, ACP1

Iloperidone

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Iloperidone

hsa00860

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Iloperidone

hsa00970

Aminoacyl-tRNA biosynthesis

3.78E-02

O95363, Q15046

FARS2, KARS

Iloperidone

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Iloperidone

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Iloperidone

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Iloperidone

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Iloperidone

hsa01210

2-Oxocarboxylic acid metabolism

1.40E-02

P50213

IDH3A

Iloperidone

hsa01230

Biosynthesis of amino acids

2.22E-03

P51854, P60891, Q99707, P37837

TKTL1, PRPS1, MTR, TALDO1

Iloperidone

hsa01522

Endocrine resistance

4.74E-02

P22694, P10415, Q13323

PRKACB, BCL2, BIK

Iloperidone

hsa01524

Platinum drug resistance

4.67E-02

Q13489, P98170, P78417, P43246

BIRC3, BIRC4, GSTO1, MSH2

Iloperidone

hsa02010

ABC transporters

1.98E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Iloperidone

hsa03008

Ribosome biogenesis in eukaryotes

1.88E-02

O14980, O60832, Q9BVP2

XPO1, DKC1, GNL3

Iloperidone

hsa03013

RNA transport

1.01E-06

O14980, P52298, Q09161, O14893, P61326, P38919, P37198, Q7Z3B4, P35658, P47813, Q14152, P55884, O75822, Q14240, P23588, Q9Y6A5, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, NUP62, NUP54, NUP214, EIF1AX, EIF3A, EIF3B, EIF3J, EIF4A2, EIF4B, TACC3, FXR1

Iloperidone

hsa03015

mRNA surveillance pathway

2.95E-02

O94913, Q9H307, Q13148

PCF11, PNN, TARDBP

Iloperidone

hsa03020

RNA polymerase

4.40E-02

P24928, P62487

POLR2A, POLR2G

Iloperidone

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Iloperidone

hsa03040

Spliceosome

2.94E-08

Q14562, O43143, O60508, P08579, P26368, O75940, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX8, DHX15, CDC40, SNRPB2, U2AF2, SMNDC1, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.853
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.818
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.809
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75940	SMNDC1	Survival of motor neuron-related-splicing factor 30	0.786
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75494	FUSIP1	Serine/arginine-rich splicing factor 10	0.73
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.879
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.776
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.806
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.758
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.87
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Iloperidone

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Iloperidone

hsa03410

Base excision repair

7.59E-03

P27695

APEX1

Iloperidone

hsa04014

Ras signaling pathway

1.30E-03

P42338, P20827, Q9NRA1, P49767, Q13009, P17252, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174

PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, PRKCA, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1

Iloperidone

hsa04015

Rap1 signaling pathway

2.42E-03

P20827, Q9NRA1, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P0DP23, P17252, P19174

EFNA1, PDGFC, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, CALM1, PRKCA, PLCG1

Iloperidone

hsa04020

Calcium signaling pathway

1.01E-03

P17252, P30679, O15399, P19174, P0DP23, P07550, P20020, P23634, Q9NRA1, P49767

PRKCA, GNA15, GRIN2D, PLCG1, CALM1, ADRB2, ATP2B1, ATP2B4, PDGFC, VEGFC

Iloperidone

hsa04022

cGMP-PKG signaling pathway

2.55E-02

P18848, Q8WYR1, P05141, P0DP24

ATF4, PIK3R5, SLC25A5, CALM2

Iloperidone

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Iloperidone

hsa04062

Chemokine signaling pathway

7.15E-05

P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P07948	LYN	Tyrosine-protein kinase Lyn	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P43250	GRK6	G protein-coupled receptor kinase 6	0.815
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.771
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Iloperidone

hsa04064

NF-kappa B signaling pathway

2.15E-02

P14778, P19174, Q04759, P06239, P09341, P19875, Q06643

IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTB

Iloperidone

hsa04070

Phosphatidylinositol signaling system

4.40E-02

P19174, P0DP23, P23743, P17252

PLCG1, CALM1, DGKA, PRKCA

Iloperidone

hsa04071

Sphingolipid signaling pathway

6.08E-04

P21453, Q9H228, P01375, Q13362, Q9UQC2

S1PR1, EDG8, TNF, PPP2R5C, GAB2

Iloperidone

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Iloperidone

hsa04080

Neuroactive ligand-receptor interaction

2.95E-04

P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, P07550

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2

Iloperidone

hsa04114

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Iloperidone

hsa04120

Ubiquitin mediated proteolysis

3.42E-03

Q14145, Q13042, P30260, Q13191, P62837, Q15751

KEAP1, CDC16, CDC27, CBLB, UBE2D2, HERC1

Iloperidone

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Iloperidone

hsa04140

Autophagy - animal

4.74E-02

P22694, Q14643, P10415

PRKACB, ITPR1, BCL2

Iloperidone

hsa04145

Phagosome

4.68E-02

Q15080, P14598, Q13509, P68371, Q13488

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1

Iloperidone

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Iloperidone

hsa04151

PI3K-Akt signaling pathway

1.67E-03

P62753, P42338, P43657, O43521, P27348, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P18848, O00141, Q6ZUJ8, P30281

RPS6, PIK3CB, P2RY5, BCL2L11, YWHAQ, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, ATF4, SGK, PIK3AP1, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P61073	CXCR4	C-X-C chemokine receptor type 4	P62753	RPS6	40S ribosomal protein S6	0.709
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P61073	CXCR4	C-X-C chemokine receptor type 4	P27348	YWHAQ	14-3-3 protein theta	0.708
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P61073	CXCR4	C-X-C chemokine receptor type 4	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P61073	CXCR4	C-X-C chemokine receptor type 4	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.755
P61073	CXCR4	C-X-C chemokine receptor type 4	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Iloperidone

hsa04210

Apoptosis

4.66E-03

O76075, P01375, Q9NR28, O75460, Q16548, O43521, P18848

DFFB, TNF, DIABLO, ERN1, BCL2A1, BCL2L11, ATF4

Iloperidone

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Iloperidone

hsa04217

Necroptosis

1.46E-08

P01375, P01568, P48023, Q13489, P98170, P42224, Q14765, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q9H444, O43633, P21796, Q08752

TNF, IFNA21, FASLG, BIRC3, BIRC4, STAT1, STAT4, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP4B, CHMP2A, VDAC1, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P01568	IFNA21	Interferon alpha-21	0.729
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P98170	BIRC4	E3 ubiquitin-protein ligase XIAP	0.716
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.826
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.724
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P15104	GLUL	Glutamine synthetase	0.745
P61073	CXCR4	C-X-C chemokine receptor type 4	P15104	GLUL	Glutamine synthetase	0.754
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P61073	CXCR4	C-X-C chemokine receptor type 4	P0C0S5	H2AFZ	Histone H2A.Z	0.732
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.75
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q93077	HIST1H2AC	Histone H2A type 1-C	0.715
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P61073	CXCR4	C-X-C chemokine receptor type 4	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.731
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.881
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	-0.844
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.728
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771

Iloperidone

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Iloperidone

hsa04330

Notch signaling pathway

2.77E-02

Q92542, P49768

NCSTN, PSEN1

Iloperidone

hsa04340

Hedgehog signaling pathway

7.27E-04

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Iloperidone

hsa04360

Axon guidance

3.14E-03

P16333, P20827, O95631, P17252, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PRKCA, PIK3CB, FES, PLCG1

Iloperidone

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Iloperidone

hsa04371

Apelin signaling pathway

2.03E-05

P62873, P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23

GNB1, GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1

Iloperidone

hsa04380

Osteoclast differentiation

1.02E-02

Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2

Iloperidone

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Iloperidone

hsa04540

Gap junction

1.19E-03

P17252, P22694, Q13509, P68371, Q9NRA1, Q14643

PRKCA, PRKACB, TUBB3, TUBB2C, PDGFC, ITPR1

Iloperidone

hsa04550

Signaling pathways regulating pluripotency of stem cells

2.16E-02

P04628, P40189

WNT1, IL6ST

Iloperidone

hsa04610

Complement and coagulation cascades

1.91E-03

P0C0L4

C4A

Iloperidone

hsa04612

Antigen processing and presentation

1.07E-03

Q14953, P26715, P26717, Q13241, P01732, P01375

KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Iloperidone

hsa04613

Neutrophil extracellular trap formation

2.18E-03

P04908, Q93077, P62807, O60814, P68431, O43315, Q16539

H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14

Iloperidone

hsa04623

Cytosolic DNA-sensing pathway

1.66E-03

P01568, P25963

IFNA21, NFKBIA

Iloperidone

hsa04625

C-type lectin receptor signaling pathway

3.87E-02

Q9ULY5, P20749, P01375, Q16539

CLEC4E, BCL3, TNF, MAPK14

Iloperidone

hsa04630

JAK-STAT signaling pathway

3.09E-03

O75925, P40189, Q06124

PIAS1, IL6ST, PTPN11

Iloperidone

hsa04640

Hematopoietic cell lineage

1.37E-02

P14778, P27930, P11215, P25063, P07766, P01732, P09564

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7

Iloperidone

hsa04650

Natural killer cell mediated cytotoxicity

3.09E-07

P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, P26717, Q14953, P26715

PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1

Iloperidone

hsa04657

IL-17 signaling pathway

9.87E-06

P25963, P08238, O00463, Q07955, Q16539, P49841, P19875, P14780, P04141, P80188, P01375, P06702

NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL2, MMP9, CSF2, LCN2, TNF, S100A9

Iloperidone

hsa04658

Th1 and Th2 cell differentiation

2.21E-04

Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761

PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3

Iloperidone

hsa04659

Th17 cell differentiation

9.05E-05

Q04759, P19174, P06239, P14784, P14778, Q9UL17, P84022, Q13485, P08238, P07766, P20963

PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD247

Iloperidone

hsa04660

T cell receptor signaling pathway

4.48E-04

P04141, P25963, Q04759, P42338, P10747, P19174, P16333, P07766, P20963, P01732, Q13191, P06239, P29350

CSF2, NFKBIA, PRKCQ, PIK3CB, CD28, PLCG1, NCK1, CD3E, CD247, CD8A, CBLB, LCK, PTPN6

Iloperidone

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Iloperidone

hsa04664

Fc epsilon RI signaling pathway

2.40E-03

P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917

TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5

Iloperidone

hsa04668

TNF signaling pathway

1.71E-04

P01375, O00463, Q16539, P18848, P19875, P01584, P20749, P14780, P20333

TNF, TRAF5, MAPK14, ATF4, CXCL2, IL1B, BCL3, MMP9, TNFRSF1B

Iloperidone

hsa04713

Circadian entrainment

2.13E-04

O15399, P0DP23, P17252, P62873, P63218, P50151, O15055

GRIN2D, CALM1, PRKCA, GNB1, GNG5, GNG10, PER2

Iloperidone

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Iloperidone

hsa04720

Long-term potentiation

9.85E-04

Q16566, P16298, P0DP23, P51812, O15399, Q02750

CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, MAP2K1

Iloperidone

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Iloperidone

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Iloperidone

hsa04724

Glutamatergic synapse

1.11E-03

O15399, P62873, P63218, P50151, P15104

GRIN2D, GNB1, GNG5, GNG10, GLUL

Iloperidone

hsa04725

Cholinergic synapse

9.05E-04

P22694, Q14643, P62873, P63218, P50151, Q16566, P10415

PRKACB, ITPR1, GNB1, GNG5, GNG10, CAMK4, BCL2

Iloperidone

hsa04726

Serotonergic synapse

2.38E-02

P62873, P63218, P50151, P09917

GNB1, GNG5, GNG10, ALOX5

Iloperidone

hsa04727

GABAergic synapse

2.45E-03

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Iloperidone

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Iloperidone

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Iloperidone

hsa04744

Phototransduction

8.39E-05

P62873, P0DP23

GNB1, CALM1

Iloperidone

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Iloperidone

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Iloperidone

hsa04913

Ovarian steroidogenesis

1.27E-03

P42330, P22694

AKR1C3, PRKACB

Iloperidone

hsa04914

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Iloperidone

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Iloperidone

hsa04920

Adipocytokine signaling pathway

4.76E-03

Q06124, Q9Y478

PTPN11, PRKAB1

Iloperidone

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Iloperidone

hsa04924

Renin secretion

2.90E-04

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Iloperidone

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Iloperidone

hsa04927

Cortisol synthesis and secretion

1.27E-03

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Iloperidone

hsa04928

Parathyroid hormone synthesis, secretion and action

1.02E-02

Q14643, P22694, P23771, P10415

ITPR1, PRKACB, GATA3, BCL2

Iloperidone

hsa04931

Insulin resistance

9.16E-04

P01375, P49841, Q06124, P06737, Q9Y478

TNF, GSK3B, PTPN11, PYGL, PRKAB1

Iloperidone

hsa04932

Non-alcoholic fatty liver disease

1.52E-05

P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, Q16718, O14521

TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, NDUFA5, SDHD

Iloperidone

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.52E-03

P84022, Q13485, P42224, P42338, Q12778, P49767, P17252, P19174

SMAD3, SMAD4, STAT1, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1

Iloperidone

hsa04934

Cushing syndrome

4.74E-02

Q14643, P22694, P04628

ITPR1, PRKACB, WNT1

Iloperidone

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Iloperidone

hsa04964

Proximal tubule bicarbonate reclamation

4.48E-02

P00918

CA2

Iloperidone

hsa04966

Collecting duct acid secretion

4.48E-02

P00918

CA2

Iloperidone

hsa04970

Salivary secretion

9.44E-04

P07550, P22694, Q14643, P49913

ADRB2, PRKACB, ITPR1, CAMP

Iloperidone

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Iloperidone

hsa04976

Bile secretion

1.67E-03

O43315, P22694, P08183

AQP9, PRKACB, ABCB1

Iloperidone

hsa05010

Alzheimer disease

2.78E-02

P13073, O75460, P0DP24, P01584, P18848, P05141

COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5

Iloperidone

hsa05012

Parkinson disease

6.61E-03

Q16718, O14521, P13073, P05141, O75460, P18848, P19174, P0DP23, P0DP24, Q13509, P68371

NDUFA5, SDHD, COX4I1, SLC25A5, ERN1, ATF4, PLCG1, CALM1, CALM2, TUBB3, TUBB2C

Iloperidone

hsa05016

Huntington disease

4.87E-02

P13073, P24928, P62487, P05141, O75460

COX4I1, POLR2A, POLR2G, SLC25A5, ERN1

Iloperidone

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Iloperidone

hsa05022

Pathways of neurodegeneration - multiple diseases

1.15E-04

Q13509, P68371, P49841, Q16718, O14521, P13073, O75460, P18848, Q13561, P19174, P05141, P17252, P20333, Q16539, P01584, Q08752, P0DP23, P0DP24

TUBB3, TUBB2C, GSK3B, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, PLCG1, SLC25A5, PRKCA, TNFRSF1B, MAPK14, IL1B, PPID, CALM1, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13509	TUBB3	Tubulin beta-3 chain	-0.808
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P68371	TUBB2C	Tubulin beta-4B chain	-0.721
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.812
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.712
P61073	CXCR4	C-X-C chemokine receptor type 4	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.717
P61073	CXCR4	C-X-C chemokine receptor type 4	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.702
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13561	DCTN2	Dynactin subunit 2	-0.744
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P17252	PRKCA	Protein kinase C alpha type	0.832
P61073	CXCR4	C-X-C chemokine receptor type 4	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.706
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.728
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P0DP23	CALM1	Calmodulin-1	-0.761
P61073	CXCR4	C-X-C chemokine receptor type 4	P0DP24	CALM2	Calmodulin-2	0.759

Iloperidone

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Iloperidone

hsa05032

Morphine addiction

1.34E-02

P62873, P63218, P50151, P43250

GNB1, GNG5, GNG10, GRK6

Iloperidone

hsa05033

Nicotine addiction

1.22E-02

P28472, O15399

GABRB3, GRIN2D

Iloperidone

hsa05034

Alcoholism

4.45E-05

O15399, Q16566, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431

GRIN2D, CAMK4, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Iloperidone

hsa05110

Vibrio cholerae infection

1.98E-02

Q13488, P17252, P19174

TCIRG1, PRKCA, PLCG1

Iloperidone

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.78E-03

P09341, P19875, P19174, P25024, P25025

CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Iloperidone

hsa05132

Salmonella infection

1.70E-02

P25963, P08238, P04406, O75369, Q13561, Q13509, P68371, P49754

NFKBIA, HSP90AB1, GAPDH, FLNB, DCTN2, TUBB3, TUBB2C, VPS41

Iloperidone

hsa05133

Pertussis

3.51E-02

P0C0L4

C4A

Iloperidone

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Iloperidone

hsa05140

Leishmaniasis

7.29E-04

P14598, P42224, P25963, P29350, Q15080

NCF1, STAT1, NFKBIA, PTPN6, NCF4

Iloperidone

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Iloperidone

hsa05144

Malaria

1.91E-02

P01375, P35443, P26718

TNF, THBS4, KLRK1

Iloperidone

hsa05146

Amoebiasis

2.05E-05

P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814

CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1

Iloperidone

hsa05150

Staphylococcus aureus infection

1.62E-03

P0C0L4, P21462, P13646, Q14532, P59665, P59666

C4A, FPR1, KRT13, KRT32, DEFA1; DEFA1B, DEFA3

Iloperidone

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Iloperidone

hsa05163

Human cytomegalovirus infection

1.64E-03

P01375, P62873, P63218, P50151, P0DP23, P49841, P14778, P25025, Q16539, O00463, P30101, P01568

TNF, GNB1, GNG5, GNG10, CALM1, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5, PDIA3, IFNA21

Iloperidone

hsa05167

Kaposi sarcoma-associated herpesvirus infection

2.17E-05

P01568, P42224, P25963, P40189, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P04141, P0DP23, P0CG47

IFNA21, STAT1, NFKBIA, IL6ST, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, CSF2, CALM1, UBB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P01568	IFNA21	Interferon alpha-21	0.729
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P40189	IL6ST	Interleukin-6 receptor subunit beta	-0.746
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.833
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P07948	LYN	Tyrosine-protein kinase Lyn	0.767
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	0.757
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P0DP23	CALM1	Calmodulin-1	-0.761
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741

Iloperidone

hsa05168

Herpes simplex virus 1 infection

9.23E-06

P25963, P01568, Q05823, Q9GZY0, P42224, Q07955, Q01130, P84103, Q13243, Q13489, P30101, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9NZL3, Q9UDV6

NFKBIA, IFNA21, RNASEL, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS3, SFRS5, BIRC3, PDIA3, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF224, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P01568	IFNA21	Interferon alpha-21	0.729
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P09960	LTA4H	Leukotriene A-4 hydrolase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.752
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.704
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.776
P09960	LTA4H	Leukotriene A-4 hydrolase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.732
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.806
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.758
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.703
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.87
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.819
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.731
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P30101	PDIA3	Protein disulfide-isomerase A3	-0.825
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q13398	ZNF211	Zinc finger protein 211	-0.759
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13398	ZNF211	Zinc finger protein 211	0.729
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13398	ZNF211	Zinc finger protein 211	-0.886
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9HCX3	ZNF304	Zinc finger protein 304	-0.746
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q03923	ZNF85	Zinc finger protein 85	0.79
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P52738	ZNF140	Zinc finger protein 140	0.717
P09960	LTA4H	Leukotriene A-4 hydrolase	P52738	ZNF140	Zinc finger protein 140	-0.724
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75820	ZNF189	Zinc finger protein 189	0.715
P09960	LTA4H	Leukotriene A-4 hydrolase	O75820	ZNF189	Zinc finger protein 189	-0.722
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q9NZL3	ZNF224	Zinc finger protein 224	-0.762
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q9UDV6	ZNF212	Zinc finger protein 212	-0.808
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9UDV6	ZNF212	Zinc finger protein 212	0.824

Iloperidone

hsa05170

Human immunodeficiency virus 1 infection

3.86E-04

Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P23528, P20333

MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, CFL1, TNFRSF1B

Iloperidone

hsa05171

Coronavirus disease - COVID-19

1.36E-02

P25963, P42224, P01568, P40189, P04141, P19174, P17252

NFKBIA, STAT1, IFNA21, IL6ST, CSF2, PLCG1, PRKCA

Iloperidone

hsa05200

Pathways in cancer

2.06E-06

Q13751, P42338, P08238, P42224, P25963, P19174, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, Q13489, P98170, P49767, Q12778, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P40189, P01042

LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BIRC3, BIRC4, VEGFC, FOXO1, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13751	LAMB3	Laminin subunit beta-3	0.868
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.826
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.724
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.912
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.739
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P17252	PRKCA	Protein kinase C alpha type	0.832
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P43246	MSH2	DNA mismatch repair protein Msh2	-0.768
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P43246	MSH2	DNA mismatch repair protein Msh2	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.847
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.899
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P14923	JUP	Junction plakoglobin	0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.715
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P98170	BIRC4	E3 ubiquitin-protein ligase XIAP	0.716
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P49767	VEGFC	Vascular endothelial growth factor C	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Q12778	FOXO1	Forkhead box protein O1	0.753
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.833
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.709
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.759
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.744
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P78417	GSTO1	Glutathione S-transferase omega-1	0.754
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.713
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.708
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P0DP23	CALM1	Calmodulin-1	-0.761
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P0DP23	CALM1	Calmodulin-1	-0.724
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P01568	IFNA21	Interferon alpha-21	0.729
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01568	IFNA21	Interferon alpha-21	0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
Q13370	PDE3B	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	P40189	IL6ST	Interleukin-6 receptor subunit beta	-0.746
Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	P01042	KNG1	Kininogen-1	0.708

Iloperidone

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Iloperidone

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Iloperidone

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Iloperidone

hsa05210

Colorectal cancer

4.67E-02

P84022, Q13485, P43246, O75293

SMAD3, SMAD4, MSH2, GADD45B

Iloperidone

hsa05212

Pancreatic cancer

3.46E-03

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Iloperidone

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Iloperidone

hsa05214

Glioma

8.71E-04

P0DP23, Q16566, P17252, P19174, O75293

CALM1, CAMK4, PRKCA, PLCG1, GADD45B

Iloperidone

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Iloperidone

hsa05222

Small cell lung cancer

3.80E-02

Q13751, Q13489, P98170, O75293

LAMB3, BIRC3, BIRC4, GADD45B

Iloperidone

hsa05226

Gastric cancer

8.67E-03

Q02750, O15169, P04628, P10826

MAP2K1, AXIN1, WNT1, RARB

Iloperidone

hsa05231

Choline metabolism in cancer

2.25E-03

Q9NRA1, Q9Y259, P19174, P23743, P17252

PDGFC, CHKB, PLCG1, DGKA, PRKCA

Iloperidone

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

7.13E-04

P25963, P42338, P19174, P07766, P20963, P06239, P29350, P42224, P10747, Q04759

NFKBIA, PIK3CB, PLCG1, CD3E, CD247, LCK, PTPN6, STAT1, CD28, PRKCQ

Iloperidone

hsa05321

Inflammatory bowel disease

1.91E-02

P01375, Q14765, Q9UL17

TNF, STAT4, TBX21

Iloperidone

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Iloperidone

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Iloperidone

hsa05332

Graft-versus-host disease

7.27E-04

P48023, P01375, P26715, Q13241

FASLG, TNF, KLRC1, KLRD1

Iloperidone

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.48E-02

P54284

CACNB3

Iloperidone

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Iloperidone

hsa05415

Diabetic cardiomyopathy

1.87E-05

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH

Iloperidone

hsa05418

Fluid shear stress and atherosclerosis

1.08E-03

Q16539, Q14145, P10599, P14780, P01375, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2

Community members of Iloperidone (S_DC: 7.44)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

DRD2

D(2) dopamine receptor

Reported

0.0604

0.4779

2.5081

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

P27695

APEX1

DNANone(apurinic or apyrimidinic site) endonuclease

Predicted

0.402

0.221

0.1217

0.7647

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

Q96KQ7

EHMT2

HistoneNonelysine NNonemethyltransferase EHMT2

Predicted

0.0728

0.2165

0.2909

0.7603

P26358

DNMT1

DNA

Predicted

0.3404

0.2809

0.2659

0.998

P61073

CXCR4

CNoneXNoneC chemokine receptor type 4

Predicted

0.2823

0.4018

0.648

1.5927

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

Q13370

PDE3B

cGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase B

Predicted

0.0906

0.1614

0.3558

0.7239

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P21453

S1PR1

Sphingosine 1Nonephosphate receptor 1

Predicted

0.1434

0.3847

0.221

1.0621

P30679

GNA15

Guanine nucleotideNonebinding protein subunit alphaNone15

Predicted

0.0373

0.1146

0.2891

0.5369

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

Q92769

HDAC2

Histone deacetylase 2

Predicted

0.0473

0.986

3.0097

Q9Y478

PRKAB1

5'NoneAMPNoneactivated protein kinase subunit betaNone1

Predicted

0.1478

0.1088

0.5564

0.8479

P49768

PSEN1

PresenilinNone1

Predicted

0.2677

0.6599

0.3308

1.7845

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

Gene name	UniProt_ID	Bioactivity	Value (nM)
DRD2	P14416	IC50	110
DRD2	P14416	Ki	0.35
DRD2	P14416	Ki	3.3
DRD2	P14416	Ki	6.3

PharmaCoNets of Iloperidone (SPCN: 152.82 )

Iloperidone regulated-network (SDN: 20.54)

Community members of Iloperidone (SDC: 7.44)

PharmaCoNets of Iloperidone (S_PCN: 152.82 )

Iloperidone regulated-network (S_DN: 20.54)

Community members of Iloperidone (S_DC: 7.44)