PharmaCoNets of Idelalisib (SPCN: 351.98 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Idelalisibhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Idelalisibhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Idelalisibhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Idelalisibhsa00051Fructose and mannose metabolism2.84E-045P15121, P19367, P08237, P60174, P04075AKR1B1, HK1, PFKM, TPI1, ALDOAMore
Idelalisibhsa00052Galactose metabolism3.77E-045P06280, P08237, O43451, P15121, P19367GLA, PFKM, MGAM, AKR1B1, HK1More
Idelalisibhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Idelalisibhsa00190Oxidative phosphorylation1.94E-063Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Idelalisibhsa00220Arginine biosynthesis1.26E-033P15104, P05089, P49448GLUL, ARG1, GLUD2More
Idelalisibhsa00230Purine metabolism4.93E-021P21589NT5EMore
Idelalisibhsa00240Pyrimidine metabolism1.81E-021P21589NT5EMore
Idelalisibhsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Idelalisibhsa00310Lysine degradation2.36E-034Q96KQ7, Q8NEZ4, Q13029, P51648EHMT2, MLL3, PRDM2, ALDH3A2More
Idelalisibhsa00500Starch and sucrose metabolism3.06E-054O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Idelalisibhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Idelalisibhsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Idelalisibhsa00520Amino sugar and nucleotide sugar metabolism7.84E-043Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Idelalisibhsa00562Inositol phosphate metabolism1.45E-033Q14642, P29218, P19174INPP5A, IMPA1, PLCG1More
Idelalisibhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.01E-021Q14442PIGHMore
Idelalisibhsa00564Glycerophospholipid metabolism3.49E-047P48651, Q9Y6K0, P35790, Q9Y259, P23743, P49619, Q3LIE5PTDSS1, CEPT1, CHKA, CHKB, DGKA, DGKG, ADPRMMore
Idelalisibhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Idelalisibhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Idelalisibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Idelalisibhsa00600Sphingolipid metabolism1.77E-034Q9BX95, Q8TCT0, Q06136, P15289SGPP1, CERK, FVT1, ARSAMore
Idelalisibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series7.02E-032P06865, O75752HEXA, B3GALNT1More
Idelalisibhsa00630Glyoxylate and dicarboxylate metabolism1.57E-053P40925, P40926, P15104MDH1, MDH2, GLULMore
Idelalisibhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Idelalisibhsa00670One carbon pool by folate7.39E-043O95954, P04818, Q99707FTCD, TYMS, MTRMore
Idelalisibhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Idelalisibhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Idelalisibhsa00760Nicotinate and nicotinamide metabolism9.09E-031P21589NT5EMore
Idelalisibhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Idelalisibhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Idelalisibhsa00830Retinol metabolism2.17E-034P00325, P00352, Q9BPW9, O75911ADH1B, ALDH1A1, DHRS9, DHRS3More
Idelalisibhsa00860Porphyrin and chlorophyll metabolism8.96E-042P36551, P30043CPOX, BLVRBMore
Idelalisibhsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Idelalisibhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Idelalisibhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Idelalisibhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Idelalisibhsa00983Drug metabolism - other enzymes1.43E-033P04183, P32320, P05164TK1, CDA, MPOMore
Idelalisibhsa01040Biosynthesis of unsaturated fatty acids2.92E-022P22307, Q9H5J4SCP2, ELOVL6More
Idelalisibhsa01100Metabolic pathways5.45E-0445Q9NR34, Q9Y234, P35790, P05089, Q16772, P30041, P19367, P48426, Q14642, P29218, P22557, P32320, P20839, P22748, P55809, P06280, Q16875, O43286, O43451, Q9Y6K0, Q14376, P05186, P24666, P15121, P08237, O95861, P07101, Q9HCC0, P33121, Q9UHK6, Q86VZ5, P48651, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P14927, P12074MAN1C1, LIPT1, CHKA, ARG1, GSTA3, PRDX6, HK1, PIP4K2A, INPP5A, IMPA1, ALAS2, CDA, IMPDH1, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, CEPT1, GALE, ALPL, ACP1, AKR1B1, PFKM, BPNT1, TH, MCCC2, ACSL1, AMACR, SGMS1, PTDSS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, UQCRB, COX6A1More
Idelalisibhsa01230Biosynthesis of amino acids1.29E-059P60174, P04075, P51854, P60891, Q99707, O75390, P50213, P15104, P37837TPI1, ALDOA, TKTL1, PRPS1, MTR, CS, IDH3A, GLUL, TALDO1More
Idelalisibhsa01240Biosynthesis of cofactors3.44E-035Q969G6, P36551, P22557, O60701, Q9Y234RFK, CPOX, ALAS2, UGDH, LIPT1More
Idelalisibhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Idelalisibhsa01522Endocrine resistance2.60E-048P22694, P04049, Q02750, Q9UM47, P46527, P08069, P10415, Q13323PRKACB, RAF1, MAP2K1, NOTCH3, CDKN1B, IGF1R, BCL2, BIKMore
Idelalisibhsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Idelalisibhsa01524Platinum drug resistance4.78E-021P31751AKT2More
Idelalisibhsa02010ABC transporters1.39E-042P45844, Q8IZY2ABCG1, ABCA7More
Idelalisibhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Idelalisibhsa03013RNA transport2.45E-1119O14980, P52298, Q09161, O14893, P61326, P38919, Q9H307, P37198, Q7Z3B4, P35658, Q14152, P55884, O75822, Q14240, Q9BZI7, P23588, Q9Y6A5, Q06787, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, PNN, NUP62, NUP54, NUP214, EIF3A, EIF3B, EIF3J, EIF4A2, UPF3B, EIF4B, TACC3, FMR1, FXR1More
Idelalisibhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Idelalisibhsa03020RNA polymerase1.64E-033P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Idelalisibhsa03040Spliceosome4.66E-1019Q14562, O43143, O60508, P17844, P08579, P26368, O75940, P51991, P61978, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, DDX5, SNRPB2, U2AF2, SMNDC1, HNRPA3, HNRPK, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Idelalisibhsa03050Proteasome4.83E-021P55036PSMD4More
Idelalisibhsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Idelalisibhsa03450Non-homologous end-joining1.58E-043Q9NP87, P78527, P13010POLM, PRKDC, XRCC5More
Idelalisibhsa03460Fanconi anemia pathway2.71E-021O94782USP1More
Idelalisibhsa04010MAPK signaling pathway1.69E-032P04049, P08069RAF1, IGF1RMore
Idelalisibhsa04012ErbB signaling pathway6.84E-045P16333, Q13191, P19174, P01106, P04049NCK1, CBLB, PLCG1, MYC, RAF1More
Idelalisibhsa04014Ras signaling pathway1.00E-0515Q02750, P04049, P31751, P20827, Q15389, Q9NRA1, P49767, P08069, P17252, P21359, P0DP23, P62873, P62879, P19174, P22694MAP2K1, RAF1, AKT2, EFNA1, ANGPT1, PDGFC, VEGFC, IGF1R, PRKCA, NF1, CALM1, GNB1, GNB2, PLCG1, PRKACBMore
Idelalisibhsa04015Rap1 signaling pathway5.94E-0510P04049, P20827, Q9NRA1, P49767, P08069, P11215, P31751, P0DP23, P17252, P19174RAF1, EFNA1, PDGFC, VEGFC, IGF1R, ITGAM, AKT2, CALM1, PRKCA, PLCG1More
Idelalisibhsa04020Calcium signaling pathway2.71E-037P27987, P17252, P19174, P0DP23, P20020, Q9NRA1, P49767ITPKB, PRKCA, PLCG1, CALM1, ATP2B1, PDGFC, VEGFCMore
Idelalisibhsa04022cGMP-PKG signaling pathway2.62E-043P04049, P31751, P0DP23RAF1, AKT2, CALM1More
Idelalisibhsa04024cAMP signaling pathway1.30E-043P31751, P0DP23, P04049AKT2, CALM1, RAF1More
Idelalisibhsa04060Cytokine-cytokine receptor interaction8.46E-0414P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, P78552, P25024, Q9UBD3, P47992, P09341, P80075, P01730IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CCL8, CD4More
Idelalisibhsa04061Viral protein interaction with cytokine and cytokine receptor1.70E-038P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RBMore
Idelalisibhsa04062Chemokine signaling pathway1.90E-0414P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, P04049CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RAF1More
Idelalisibhsa04064NF-kappa B signaling pathway4.81E-1226P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Idelalisibhsa04066HIF-1 signaling pathway1.49E-025P08069, P17252, Q15389, Q02750, P46527IGF1R, PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Idelalisibhsa04068FoxO signaling pathway3.80E-042P04049, P08069RAF1, IGF1RMore
Idelalisibhsa04070Phosphatidylinositol signaling system1.86E-0711P19174, P0DP23, Q14643, P23743, P49619, Q86XP1, P29218, Q14642, P27987, Q96DU7, P17252PLCG1, CALM1, ITPR1, DGKA, DGKG, DGKH, IMPA1, INPP5A, ITPKB, ITPKC, PRKCAMore
Idelalisibhsa04071Sphingolipid signaling pathway1.82E-037P04049, P17252, P21453, Q9H228, Q13362, Q9BX95, P10415RAF1, PRKCA, S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Idelalisibhsa04072Phospholipase D signaling pathway2.31E-026P04049, P42338, P43657, P25024, P25025, P19174RAF1, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Idelalisibhsa04080Neuroactive ligand-receptor interaction3.22E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1More
Idelalisibhsa04110Cell cycle3.67E-069Q9UBD5, P06493, O60566, P78527, Q14683, P30304, P33981, P42773, P01106ORC3, CDK1, BUB1B, PRKDC, SMC1A, CDC25A, TTK, CDKN2C, MYCMore
Idelalisibhsa04114Oocyte meiosis1.41E-046Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1RMore
Idelalisibhsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Idelalisibhsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Idelalisibhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Idelalisibhsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Idelalisibhsa04140Autophagy - animal4.11E-027P08069, P04049, P22694, Q14643, P10415, Q9H1Y0, Q04759IGF1R, RAF1, PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Idelalisibhsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Idelalisibhsa04142Lysosome2.45E-039Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Idelalisibhsa04144Endocytosis1.13E-0314Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5More
Idelalisibhsa04145Phagosome4.65E-0513O75015, Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Idelalisibhsa04150mTOR signaling pathway1.32E-035P08069, P04049, Q02750, Q9NQL2, P51812IGF1R, RAF1, MAP2K1, RRAGD, RPS6KA3More
Idelalisibhsa04151PI3K-Akt signaling pathway1.13E-0316P62753, P25116, P27348, P49767, Q13362, P07900, P62873, P16144, P22105, O60603, P01568, Q99941, P18848, P10415, P17252, O00141RPS6, F2R, YWHAQ, VEGFC, PPP2R5C, HSP90AA1, GNB1, ITGB4, TNXB, TLR2, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGKMore
Idelalisibhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Idelalisibhsa04210Apoptosis4.14E-039Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643, P04049ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1, RAF1More
Idelalisibhsa04211Longevity regulating pathway1.71E-047Q12778, P08069, P51828, Q99941, P18848, Q9UEF7, Q96KQ7FOXO1, IGF1R, ADCY7, CREBL1, ATF4, KL, EHMT2More
Idelalisibhsa04213Longevity regulating pathway - multiple species3.95E-058P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Idelalisibhsa04217Necroptosis2.89E-0714P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, P10415, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP2A, PPIDMore
Idelalisibhsa04218Cellular senescence1.14E-047P31751, P04049, P0DP23, P01889, P10321, P05141, P12236AKT2, RAF1, CALM1, HLA-B, HLA-C, SLC25A5, SLC25A6More
Idelalisibhsa04261Adrenergic signaling in cardiomyocytes2.02E-0410P09493, P51828, P31751, Q99941, P18848, Q13362, P0DP23, Q13557, P17252, P10415TPM1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2More
Idelalisibhsa04270Vascular smooth muscle contraction2.48E-047P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Idelalisibhsa04310Wnt signaling pathway1.48E-033O15169, P17612, P67870AXIN1, PRKACA, CSNK2BMore
Idelalisibhsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Idelalisibhsa04340Hedgehog signaling pathway1.04E-044P17612, Q9Y496, O43791, P30279PRKACA, KIF3A, SPOP, CCND2More
Idelalisibhsa04360Axon guidance5.35E-046P16333, P20827, O95631, P17252, P04049, P19174NCK1, EFNA1, NTN1, PRKCA, RAF1, PLCG1More
Idelalisibhsa04370VEGF signaling pathway4.83E-075P16298, P31751, Q05397, Q02750, P04049PPP3CB, AKT2, PTK2, MAP2K1, RAF1More
Idelalisibhsa04371Apelin signaling pathway1.43E-043P31751, P04049, P0DP23AKT2, RAF1, CALM1More
Idelalisibhsa04380Osteoclast differentiation2.72E-048Q9NQC7, Q9UQC2, Q16539, P31751, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, AKT2, IL1R1, FCGR3B, TNF, LILRA2More
Idelalisibhsa04390Hippo signaling pathway5.79E-034P04628, Q9UJU2, O43623, Q13489WNT1, LEF1, SNAI2, BIRC3More
Idelalisibhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Idelalisibhsa04510Focal adhesion1.18E-032P04049, P08069RAF1, IGF1RMore
Idelalisibhsa04520Adherens junction8.29E-031P08069IGF1RMore
Idelalisibhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Idelalisibhsa04540Gap junction1.05E-058P17252, P22694, Q13509, P68371, Q02750, P04049, Q9NRA1, Q14643PRKCA, PRKACB, TUBB3, TUBB2C, MAP2K1, RAF1, PDGFC, ITPR1More
Idelalisibhsa04550Signaling pathways regulating pluripotency of stem cells3.80E-042P04049, P08069RAF1, IGF1RMore
Idelalisibhsa04610Complement and coagulation cascades5.97E-092P00734, P0C0L4F2, C4AMore
Idelalisibhsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Idelalisibhsa04612Antigen processing and presentation3.15E-059P13765, P48382, P01730, P26715, P26717, Q13241, P01732, P11142, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, CD8A, HSPA8, TNFMore
Idelalisibhsa04613Neutrophil extracellular trap formation1.65E-0615P19174, P17252, P04049, P11215, O60603, P08246, Q13547, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P21462PLCG1, PRKCA, RAF1, ITGAM, TLR2, ELA2, HDAC1, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1More
Idelalisibhsa04620Toll-like receptor signaling pathway4.81E-033Q13546, P01568, P31751RIPK1, IFNA21, AKT2More
Idelalisibhsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Idelalisibhsa04622RIG-I-like receptor signaling pathway1.02E-033P01568, Q9NQC7, Q13546IFNA21, CYLD, RIPK1More
Idelalisibhsa04623Cytosolic DNA-sensing pathway9.08E-085P01584, P01568, Q13546, P25963, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, CCL4L2More
Idelalisibhsa04625C-type lectin receptor signaling pathway2.59E-058Q9ULY5, P04049, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, RAF1, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Idelalisibhsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Idelalisibhsa04640Hematopoietic cell lineage7.70E-0714P13612, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNFMore
Idelalisibhsa04650Natural killer cell mediated cytotoxicity7.34E-1019P16298, P50591, P19174, P01375, P06239, O60880, P20963, Q29983, P10321, P01889, P42338, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, MICA, HLA-C, HLA-B, PIK3CB, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Idelalisibhsa04657IL-17 signaling pathway1.11E-0511P25963, P08238, O00463, Q07955, Q16539, P49841, P09341, P14780, P04141, P01375, P06702NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, CSF2, TNF, S100A9More
Idelalisibhsa04658Th1 and Th2 cell differentiation3.59E-1316P25963, Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, RUNX3More
Idelalisibhsa04659Th17 cell differentiation3.30E-1117P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Idelalisibhsa04660T cell receptor signaling pathway2.07E-0920P01375, P04141, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P29350, P04049TNF, CSF2, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, PTPN6, RAF1More
Idelalisibhsa04662B cell receptor signaling pathway3.15E-067P31751, P42338, P60033, P07948, P21854, Q8N149, P04049AKT2, PIK3CB, CD81, LYN, CD72, LILRA2, RAF1More
Idelalisibhsa04664Fc epsilon RI signaling pathway3.97E-069P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P04049, P09917, P20292TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, RAF1, ALOX5, ALOX5APMore
Idelalisibhsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Idelalisibhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Idelalisibhsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Idelalisibhsa04710Circadian rhythm3.74E-032O00327, O15055ARNTL, PER2More
Idelalisibhsa04713Circadian entrainment2.17E-035P0DP23, P17252, P62873, Q14643, O15055CALM1, PRKCA, GNB1, ITPR1, PER2More
Idelalisibhsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Idelalisibhsa04720Long-term potentiation2.05E-0811P17252, P16298, P0DP23, Q15418, P51812, P18848, P17612, P22694, Q02750, P04049, Q14643PRKCA, PPP3CB, CALM1, RPS6KA1, RPS6KA3, ATF4, PRKACA, PRKACB, MAP2K1, RAF1, ITPR1More
Idelalisibhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Idelalisibhsa04722Neurotrophin signaling pathway3.42E-058P31751, P04049, P49841, O43524, P48023, P51617, P10415, P0DP23AKT2, RAF1, GSK3B, FOXO3, FASLG, IRAK1, BCL2, CALM1More
Idelalisibhsa04723Retrograde endocannabinoid signaling1.43E-036Q14643, P17252, P48169, P62873, P17612, Q16718ITPR1, PRKCA, GABRA4, GNB1, PRKACA, NDUFA5More
Idelalisibhsa04724Glutamatergic synapse3.88E-044O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Idelalisibhsa04725Cholinergic synapse2.70E-0714P51828, P17612, P22694, Q14643, P17252, P62873, P62879, P63218, P50151, P18848, Q13557, P42338, P10415, Q02750ADCY7, PRKACA, PRKACB, ITPR1, PRKCA, GNB1, GNB2, GNG5, GNG10, ATF4, CAMK2D, PIK3CB, BCL2, MAP2K1More
Idelalisibhsa04726Serotonergic synapse4.46E-035P22694, P17252, P62879, P04049, Q02750PRKACB, PRKCA, GNB2, RAF1, MAP2K1More
Idelalisibhsa04727GABAergic synapse2.27E-0510P62873, P62879, P63218, P50151, P48169, P15104, P17612, P22694, O60296, P17252GNB1, GNB2, GNG5, GNG10, GABRA4, GLUL, PRKACA, PRKACB, TRAK2, PRKCAMore
Idelalisibhsa04728Dopaminergic synapse1.80E-0511P17612, Q14643, P17252, P62873, P31751, Q99941, P18848, Q13557, Q13362, P0DP23, O15516PRKACA, ITPR1, PRKCA, GNB1, AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, CALM1, CLOCKMore
Idelalisibhsa04730Long-term depression1.25E-042P08069, P04049IGF1R, RAF1More
Idelalisibhsa04740Olfactory transduction8.48E-053P62873, P0DP23, P17612GNB1, CALM1, PRKACAMore
Idelalisibhsa04742Taste transduction2.53E-042P48169, P17612GABRA4, PRKACAMore
Idelalisibhsa04744Phototransduction3.25E-092P62873, P0DP23GNB1, CALM1More
Idelalisibhsa04750Inflammatory mediator regulation of TRP channels7.85E-049P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Idelalisibhsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Idelalisibhsa04910Insulin signaling pathway1.27E-056Q14642, P0DP23, P04049, P31751, Q13191, Q9Y4H2INPP5A, CALM1, RAF1, AKT2, CBLB, IRS2More
Idelalisibhsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Idelalisibhsa04912GnRH signaling pathway1.31E-037P17252, P51828, P18848, Q13557, Q14643, P0DP23, P04049PRKCA, ADCY7, ATF4, CAMK2D, ITPR1, CALM1, RAF1More
Idelalisibhsa04913Ovarian steroidogenesis1.16E-021P08069IGF1RMore
Idelalisibhsa04914Progesterone-mediated oocyte maturation7.06E-056P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1More
Idelalisibhsa04915Estrogen signaling pathway8.72E-0615P14780, P22694, P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, Q14643, P0DP23, Q15788, P10415MMP9, PRKACB, RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, ITPR1, CALM1, NCOA1, BCL2More
Idelalisibhsa04916Melanogenesis1.47E-032P0DP23, P04049CALM1, RAF1More
Idelalisibhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Idelalisibhsa04918Thyroid hormone synthesis1.47E-047P22694, P51828, Q99941, P18848, Q14643, P02768, P05543PRKACB, ADCY7, CREBL1, ATF4, ITPR1, ALB, SERPINA7More
Idelalisibhsa04919Thyroid hormone signaling pathway4.56E-036P17252, P04049, Q02750, P22694, Q12778, Q9UM47PRKCA, RAF1, MAP2K1, PRKACB, FOXO1, NOTCH3More
Idelalisibhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Idelalisibhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Idelalisibhsa04922Glucagon signaling pathway2.33E-035Q12778, P31751, Q13370, P0DP23, Q14643FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Idelalisibhsa04923Regulation of lipolysis in adipocytes3.88E-034P07550, P42338, Q9Y4H2, P31751ADRB2, PIK3CB, IRS2, AKT2More
Idelalisibhsa04924Renin secretion1.70E-033Q14643, Q13370, P0DP23ITPR1, PDE3B, CALM1More
Idelalisibhsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Idelalisibhsa04926Relaxin signaling pathway1.38E-049P42338, P63218, P50151, Q99941, P18848, P49767, P51828, P04049, P49407PIK3CB, GNG5, GNG10, CREBL1, ATF4, VEGFC, ADCY7, RAF1, ARRB1More
Idelalisibhsa04927Cortisol synthesis and secretion2.37E-045Q14643, Q99941, P18848, P51828, P22694ITPR1, CREBL1, ATF4, ADCY7, PRKACBMore
Idelalisibhsa04928Parathyroid hormone synthesis, secretion and action9.81E-0511Q14643, P51828, P22694, P23771, P04049, Q02750, P17252, Q99941, P18848, P10415, Q9Y5Q3ITPR1, ADCY7, PRKACB, GATA3, RAF1, MAP2K1, PRKCA, CREBL1, ATF4, BCL2, MAFBMore
Idelalisibhsa04929GnRH secretion2.28E-044P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Idelalisibhsa04932Non-alcoholic fatty liver disease7.56E-049P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, O95298TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFC2More
Idelalisibhsa04933AGE-RAGE signaling pathway in diabetic complications6.00E-046P42224, P10415, Q12778, P49767, P17252, P19174STAT1, BCL2, FOXO1, VEGFC, PRKCA, PLCG1More
Idelalisibhsa04934Cushing syndrome6.81E-056Q99941, P18848, P51828, P17612, O15169, Q13557CREBL1, ATF4, ADCY7, PRKACA, AXIN1, CAMK2DMore
Idelalisibhsa04935Growth hormone synthesis, secretion and action5.33E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Idelalisibhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Idelalisibhsa04962Vasopressin-regulated water reabsorption7.22E-032P52566, P62491ARHGDIB, RAB11AMore
Idelalisibhsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Idelalisibhsa04966Collecting duct acid secretion1.26E-043Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Idelalisibhsa04970Salivary secretion1.22E-036Q08828, P51828, P22694, P17252, P0DP23, P49913ADCY1, ADCY7, PRKACB, PRKCA, CALM1, CAMPMore
Idelalisibhsa04971Gastric acid secretion4.78E-021P0DP23CALM1More
Idelalisibhsa04972Pancreatic secretion1.31E-022Q08828, P62491ADCY1, RAB11AMore
Idelalisibhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Idelalisibhsa04975Fat digestion and absorption1.43E-031O14494PLPP1More
Idelalisibhsa04976Bile secretion4.78E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Idelalisibhsa05010Alzheimer disease3.97E-0516Q16718, O14521, P13073, Q14643, Q00535, P0DP23, P18848, Q13509, P68371, O15169, P67870, P31751, P05141, P12236, Q08752, P28070NDUFA5, SDHD, COX4I1, ITPR1, CDK5, CALM1, ATF4, TUBB3, TUBB2C, AXIN1, CSNK2B, AKT2, SLC25A5, SLC25A6, PPID, PSMB4More
Idelalisibhsa05012Parkinson disease2.02E-0413Q16718, O14521, P13073, P05141, P12236, P17612, P18848, P28070, Q14643, P19174, P0DP23, Q13509, P68371NDUFA5, SDHD, COX4I1, SLC25A5, SLC25A6, PRKACA, ATF4, PSMB4, ITPR1, PLCG1, CALM1, TUBB3, TUBB2CMore
Idelalisibhsa05016Huntington disease2.46E-029O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12More
Idelalisibhsa05017Spinocerebellar ataxia2.22E-024Q92915, O15399, P42338, P21796FGF14, GRIN2D, PIK3CB, VDAC1More
Idelalisibhsa05020Prion disease1.63E-0414P17612, Q16718, O14521, P13073, Q14643, P18848, P05141, P12236, P28070, Q13509, P68371, P67870, P14598, Q15080PRKACA, NDUFA5, SDHD, COX4I1, ITPR1, ATF4, SLC25A5, SLC25A6, PSMB4, TUBB3, TUBB2C, CSNK2B, NCF1, NCF4More
Idelalisibhsa05022Pathways of neurodegeneration - multiple diseases2.65E-0521Q14643, Q13509, P68371, P67870, P10415, Q16718, O14521, P13073, Q06055, P18848, Q13561, P19174, P05141, P12236, P17252, Q00535, O15169, Q08752, O15020, P0DP23, P28070ITPR1, TUBB3, TUBB2C, CSNK2B, BCL2, NDUFA5, SDHD, COX4I1, ATP5G2, ATF4, DCTN2, PLCG1, SLC25A5, SLC25A6, PRKCA, CDK5, AXIN1, PPID, SPTBN2, CALM1, PSMB4More
Idelalisibhsa05030Cocaine addiction6.96E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Idelalisibhsa05031Amphetamine addiction9.24E-044P0DP23, Q13557, Q99941, P18848CALM1, CAMK2D, CREBL1, ATF4More
Idelalisibhsa05032Morphine addiction1.01E-023P17612, P62873, P48169PRKACA, GNB1, GABRA4More
Idelalisibhsa05034Alcoholism4.09E-0711P17612, P18848, P0DP23, Q96RR4, P62873, P04049, Q93077, P62807, O60814, P84243, P68431PRKACA, ATF4, CALM1, CAMKK2, GNB1, RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Idelalisibhsa05110Vibrio cholerae infection1.35E-065Q13488, Q99437, P17252, P19174, P17612TCIRG1, ATP6V0B, PRKCA, PLCG1, PRKACAMore
Idelalisibhsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Idelalisibhsa05130Pathogenic Escherichia coli infection4.08E-023Q15438, P35579, P55061PSCD1, MYH9, TEGTMore
Idelalisibhsa05131Shigellosis2.27E-028P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Idelalisibhsa05132Salmonella infection5.06E-0917P51617, P25963, P08238, P04049, Q9UJU2, Q13546, Q13489, P10415, P04406, O75369, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371, P49754IRAK1, NFKBIA, HSP90AB1, RAF1, LEF1, RIPK1, BIRC3, BCL2, GAPDH, FLNB, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C, VPS41More
Idelalisibhsa05133Pertussis2.60E-042P0DP23, P0C0L4CALM1, C4AMore
Idelalisibhsa05134Legionellosis1.51E-057P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Idelalisibhsa05140Leishmaniasis1.39E-0913P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4More
Idelalisibhsa05143African trypanosomiasis8.39E-064P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Idelalisibhsa05144Malaria1.53E-037P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Idelalisibhsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Idelalisibhsa05146Amoebiasis1.62E-0712P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Idelalisibhsa05150Staphylococcus aureus infection1.16E-036P0C0L4, P13646, Q14532, P59665, P59666, P49913C4A, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Idelalisibhsa05152Tuberculosis4.74E-0714P04049, Q13488, Q99437, P0DP23, P42224, P48382, O60603, P31751, P10415, P13765, P25774, P01568, Q9UDY8, P51617RAF1, TCIRG1, ATP6V0B, CALM1, STAT1, RFX5, TLR2, AKT2, BCL2, HLA-DOB, CTSS, IFNA21, MALT1, IRAK1More
Idelalisibhsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Idelalisibhsa05161Hepatitis B5.33E-034P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Idelalisibhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Idelalisibhsa05163Human cytomegalovirus infection1.52E-0522P31751, P04049, P01375, P01889, P10321, P62873, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P17612, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463AKT2, RAF1, TNF, HLA-B, HLA-C, GNB1, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, PRKACA, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5More
Idelalisibhsa05164Influenza A3.65E-021P04049RAF1More
Idelalisibhsa05165Human papillomavirus infection5.80E-0414P46527, Q02750, P16144, P35443, Q92796, Q05086, Q9UM47, P01568, P42224, Q13488, P22694, Q13362, Q12778, Q13315CDKN1B, MAP2K1, ITGB4, THBS4, DLG3, UBE3A, NOTCH3, IFNA21, STAT1, TCIRG1, PRKACB, PPP2R5C, FOXO1, ATMMore
Idelalisibhsa05166Human T-cell leukemia virus 1 infection7.39E-037Q9Y490, P01889, P10321, P05141, P12236, P17612, P18848TLN1, HLA-B, HLA-C, SLC25A5, SLC25A6, PRKACA, ATF4More
Idelalisibhsa05167Kaposi sarcoma-associated herpesvirus infection3.00E-0819P01568, P31751, P42224, P25963, P40189, P01889, P10321, P62873, P62879, P19174, P16298, Q14643, P04049, Q02750, Q29983, P04141, P0DP23, P0CG47, Q9UJU2IFNA21, AKT2, STAT1, NFKBIA, IL6ST, HLA-B, HLA-C, GNB1, GNB2, PLCG1, PPP3CB, ITPR1, RAF1, MAP2K1, MICA, CSF2, CALM1, UBB, LEF1More
Idelalisibhsa05168Herpes simplex virus 1 infection1.16E-0415P25963, P01568, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212More
Idelalisibhsa05169Epstein-Barr virus infection5.94E-0412P13765, P01106, Q13547, O00463, P42338, P07948, Q13761, P24522, O75293, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, CD3E, CD3G, CD247More
Idelalisibhsa05170Human immunodeficiency virus 1 infection9.21E-0817P31751, P04049, Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q14643, P01568, P51617, O60603, Q13315, P10415, Q9Y6Q5, P20333AKT2, RAF1, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, ITPR1, IFNA21, IRAK1, TLR2, ATM, BCL2, AP1M2, TNFRSF1BMore
Idelalisibhsa05171Coronavirus disease - COVID-191.36E-027P25963, P42224, P01568, P40189, P04141, P19174, P17252NFKBIA, STAT1, IFNA21, IL6ST, CSF2, PLCG1, PRKCAMore
Idelalisibhsa05200Pathways in cancer1.37E-0522P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P14923, P10415, Q13489, Q13077, P49767, Q12778, P31751, P25116, P62873, Q9UM47, O75293, P0DP23, P01568, P14784, P40189HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, JUP, BCL2, BIRC3, TRAF1, VEGFC, FOXO1, AKT2, F2R, GNB1, NOTCH3, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Idelalisibhsa05202Transcriptional misregulation in cancer8.84E-0617Q12778, Q15532, Q13315, P14780, P27930, Q15744, Q16548, Q13077, O15550, P08069, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Idelalisibhsa05203Viral carcinogenesis1.94E-0612Q99941, P18848, P30279, P27348, Q13547, Q15283, P01889, P10321, P61978, P17612, P62807, O60814CREBL1, ATF4, CCND2, YWHAQ, HDAC1, RASA2, HLA-B, HLA-C, HNRPK, PRKACA, HIST1H2BC, H2BC12More
Idelalisibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Idelalisibhsa05205Proteoglycans in cancer2.26E-036Q13009, Q12955, O75369, P04049, P08069, P08962TIAM1, ANK3, FLNB, RAF1, IGF1R, CD63More
Idelalisibhsa05206MicroRNAs in cancer1.08E-0414P30304, P46527, P09493, P30279, Q9Y4H2, Q9UM47, P16070, Q13547, Q13315, P20827, P17252, P19174, P04049, Q02750CDC25A, CDKN1B, TPM1, CCND2, IRS2, NOTCH3, CD44, HDAC1, ATM, EFNA1, PRKCA, PLCG1, RAF1, MAP2K1More
Idelalisibhsa05210Colorectal cancer2.55E-033Q9UKG1, P04049, P37173APPL1, RAF1, TGFBR2More
Idelalisibhsa05211Renal cell carcinoma1.29E-032P31751, P04049AKT2, RAF1More
Idelalisibhsa05212Pancreatic cancer1.29E-032P31751, P04049AKT2, RAF1More
Idelalisibhsa05213Endometrial cancer4.41E-044O15169, P31751, Q02750, P04049AXIN1, AKT2, MAP2K1, RAF1More
Idelalisibhsa05214Glioma9.11E-087P08069, P0DP23, P17252, P04049, P31751, P19174, O75293IGF1R, CALM1, PRKCA, RAF1, AKT2, PLCG1, GADD45BMore
Idelalisibhsa05215Prostate cancer1.65E-042P08069, P04049IGF1R, RAF1More
Idelalisibhsa05217Basal cell carcinoma4.31E-022P04628, Q9UJU2WNT1, LEF1More
Idelalisibhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Idelalisibhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Idelalisibhsa05220Chronic myeloid leukemia9.63E-042P31751, P04049AKT2, RAF1More
Idelalisibhsa05221Acute myeloid leukemia8.16E-042P31751, P04049AKT2, RAF1More
Idelalisibhsa05222Small cell lung cancer4.78E-021P31751AKT2More
Idelalisibhsa05223Non-small cell lung cancer3.49E-042P31751, P04049AKT2, RAF1More
Idelalisibhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Idelalisibhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Idelalisibhsa05226Gastric cancer3.48E-044P04049, Q02750, P31751, O15169RAF1, MAP2K1, AKT2, AXIN1More
Idelalisibhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Idelalisibhsa05231Choline metabolism in cancer1.89E-077P04049, Q9NRA1, Q9Y259, P19174, P23743, P49619, P17252RAF1, PDGFC, CHKB, PLCG1, DGKA, DGKG, PRKCAMore
Idelalisibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer6.41E-0716P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P42224, O60603, P10747, Q04759, Q16539, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, STAT1, TLR2, CD28, PRKCQ, MAPK14, CD4More
Idelalisibhsa05310Asthma1.92E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Idelalisibhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Idelalisibhsa05321Inflammatory bowel disease1.27E-057O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Idelalisibhsa05322Systemic lupus erythematosus4.80E-0610P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P62807, O60814, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Idelalisibhsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Idelalisibhsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Idelalisibhsa05332Graft-versus-host disease5.54E-066P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Idelalisibhsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Idelalisibhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Idelalisibhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Idelalisibhsa05415Diabetic cardiomyopathy2.37E-048P17252, P30405, P14598, Q15080, Q16718, O14521, P37173, P04406PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, TGFBR2, GAPDHMore
Idelalisibhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Idelalisibhsa05418Fluid shear stress and atherosclerosis1.27E-0510Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Idelalisib (SDC: 11.22)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P78527PRKDCDNANonedependent protein kinase catalytic subunitPredicted00.1780.19440.24960.7273
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
O94782USP1Ubiquitin carboxylNoneterminal hydrolase 1Predicted00.4410.08980.02130.4215
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
Q96SW2CRBNProtein cereblonPredicted00.2490.042700.2099
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
Q09472EP300Histone acetyltransferase p300Predicted00.41820.06720.93071.2742
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
Q9UBU7DBF4Protein DBF4 homolog APredicted00.00750.19610.2590.655
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
P00441SOD1Superoxide dismutase [CuNoneZn]Predicted10.53850.07130.48710.8991
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P42224STAT1Signal transducer and activator of transcription 1Nonealpha/betaPredicted10.22450.042511.1973
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P67870CSNK2BCasein kinase II subunit betaPredicted00.76770.02730.52970.9682
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
Q13370PDE3BcGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase BPredicted00.09060.16140.35580.7239
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P20292ALOX5APArachidonate 5NonelipoxygenaseNoneactivating proteinPredicted00.13030.24180.09070.6395
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)