PharmaCoNets

PharmaCoNets of Icosapent (S_PCN: 41.61 )

Icosapent regulated-network (S_DN: 14.45)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Icosapent

hsa00061

Fatty acid biosynthesis

1.52E-03

Q9UKU0

ACSL6

Icosapent

hsa00071

Fatty acid degradation

4.55E-03

Q9UKU0

ACSL6

Icosapent

hsa00280

Valine, leucine and isoleucine degradation

3.30E-02

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Icosapent

hsa00310

Lysine degradation

6.96E-03

Q96KQ7, P51648

EHMT2, ALDH3A2

Icosapent

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Icosapent

hsa00515

Mannose type O-glycan biosynthesis

4.96E-02

O75072

FCMD

Icosapent

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Icosapent

hsa00620

Pyruvate metabolism

2.18E-02

P40925, P51648

MDH1, ALDH3A2

Icosapent

hsa00630

Glyoxylate and dicarboxylate metabolism

1.10E-05

P40925, P15104

MDH1, GLUL

Icosapent

hsa00920

Sulfur metabolism

3.18E-02

Q16762

TST

Icosapent

hsa00970

Aminoacyl-tRNA biosynthesis

3.78E-02

O95363, Q15046

FARS2, KARS

Icosapent

hsa01212

Fatty acid metabolism

7.59E-03

Q9UKU0

ACSL6

Icosapent

hsa03013

RNA transport

8.19E-04

Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042

RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2

Icosapent

hsa03040

Spliceosome

1.85E-09

O43143, O60508, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
O14843	FFAR3	Free fatty acid receptor 3	O60508	CDC40	Pre-mRNA-processing factor 17	-0.728
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
O14843	FFAR3	Free fatty acid receptor 3	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.867
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
O14843	FFAR3	Free fatty acid receptor 3	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
O14843	FFAR3	Free fatty acid receptor 3	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.747
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
O14843	FFAR3	Free fatty acid receptor 3	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.738
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
O14843	FFAR3	Free fatty acid receptor 3	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Icosapent

hsa03060

Protein export

1.43E-02

P37108, Q15005

SRP14, SPCS2

Icosapent

hsa03320

PPAR signaling pathway

9.10E-03

Q9UKU0

ACSL6

Icosapent

hsa03450

Non-homologous end-joining

4.96E-02

Q9NP87

POLM

Icosapent

hsa04012

ErbB signaling pathway

3.74E-02

P21860, Q13557, O14944

ERBB3, CAMK2D, EREG

Icosapent

hsa04014

Ras signaling pathway

1.98E-03

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Icosapent

hsa04015

Rap1 signaling pathway

2.69E-03

P20827, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P08514, P19174

EFNA1, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, ITGA2B, PLCG1

Icosapent

hsa04020

Calcium signaling pathway

6.50E-04

Q96DU7, P45880, Q13557, P21860, P51828, P23634

ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4

Icosapent

hsa04022

cGMP-PKG signaling pathway

4.72E-02

Q99941, P23634, P51828, P45880

CREBL1, ATP2B4, ADCY7, VDAC2

Icosapent

hsa04062

Chemokine signaling pathway

9.23E-03

P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Icosapent

hsa04071

Sphingolipid signaling pathway

1.62E-04

P17252, P21453, Q9H228, Q13362, Q9BX95, Q16539, P10415, Q9UQC2

PRKCA, S1PR1, EDG8, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2

Icosapent

hsa04114

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Icosapent

hsa04122

Sulfur relay system

3.18E-02

Q16762

TST

Icosapent

hsa04141

Protein processing in endoplasmic reticulum

1.29E-03

P30101, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238

PDIA3, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1

Icosapent

hsa04145

Phagosome

1.81E-02

O75015, Q15080, Q13488, P05164, O60603, P35443, P13765

FCGR3B, NCF4, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Icosapent

hsa04146

Peroxisome

1.37E-02

Q9UKU0

ACSL6

Icosapent

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Icosapent

hsa04151

PI3K-Akt signaling pathway

1.89E-03

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P35610	SOAT1	Sterol O-acyltransferase 1	O15335	CHAD	Chondroadherin	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P35610	SOAT1	Sterol O-acyltransferase 1	Q13751	LAMB3	Laminin subunit beta-3	-0.805
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P35610	SOAT1	Sterol O-acyltransferase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Icosapent

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Icosapent

hsa04216

Ferroptosis

1.52E-02

Q9UKU0

ACSL6

Icosapent

hsa04261

Adrenergic signaling in cardiomyocytes

3.98E-02

P51828, Q99941, Q13557, P23634

ADCY7, CREBL1, CAMK2D, ATP2B4

Icosapent

hsa04330

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Icosapent

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Icosapent

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Icosapent

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Icosapent

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Icosapent

hsa04512

ECM-receptor interaction

3.73E-02

P07359, P08514

GP1BA, ITGA2B

Icosapent

hsa04514

Cell adhesion molecules

8.19E-03

P16109, P56750, O00501

SELP, CLDN17, CLDN5

Icosapent

hsa04530

Tight junction

1.38E-04

Q8TEU7, P16989, P56750, O00501, Q14247

RAPGEF6, CSDA, CLDN17, CLDN5, CTTN

Icosapent

hsa04610

Complement and coagulation cascades

4.47E-02

P25116, P09871

F2R, C1S

Icosapent

hsa04611

Platelet activation

5.18E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Icosapent

hsa04613

Neutrophil extracellular trap formation

1.54E-04

P17252, P16109, O60603, P05164, P08246, Q9UM07, Q6FI13, O60814, P68431, Q15080, O75015, P21730, P08514, P21462, P07359, O43315, Q16539

PRKCA, SELP, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	P17252	PRKCA	Protein kinase C alpha type	-0.757
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	P17252	PRKCA	Protein kinase C alpha type	-0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
Q15722	LTB4R	Leukotriene B4 receptor 1	O60603	TLR2	Toll-like receptor 2	0.942
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	O60603	TLR2	Toll-like receptor 2	0.903
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	P05164	MPO	Myeloperoxidase	0.7
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	P08246	ELA2	Neutrophil elastase	0.768
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.799
Q15722	LTB4R	Leukotriene B4 receptor 1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.833
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.788
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	-0.757
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.918
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.893
Q15722	LTB4R	Leukotriene B4 receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.737
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.878
Q15722	LTB4R	Leukotriene B4 receptor 1	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.875
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.843
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
Q15722	LTB4R	Leukotriene B4 receptor 1	P21462	FPR1	fMet-Leu-Phe receptor	0.888
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	P21462	FPR1	fMet-Leu-Phe receptor	0.916
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
Q15722	LTB4R	Leukotriene B4 receptor 1	O43315	AQP9	Aquaporin-9	0.79
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	O43315	AQP9	Aquaporin-9	0.918
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.721
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.886

Icosapent

hsa04640

Hematopoietic cell lineage

1.64E-03

P04234, P20036

CD3D, HLA-DPA1

Icosapent

hsa04650

Natural killer cell mediated cytotoxicity

2.94E-02

P16298, P50591, Q02750

PPP3CB, TNFSF10, MAP2K1

Icosapent

hsa04658

Th1 and Th2 cell differentiation

1.85E-03

P04234, P20036

CD3D, HLA-DPA1

Icosapent

hsa04659

Th17 cell differentiation

1.57E-04

P25963, P19174, P14784, P20036, P14778, P84022, Q13485, P08238, P07766, P04234

NFKBIA, PLCG1, IL2RB, HLA-DPA1, IL1R1, SMAD3, SMAD4, HSP90AB1, CD3E, CD3D

Icosapent

hsa04662

B cell receptor signaling pathway

9.03E-05

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Icosapent

hsa04664

Fc epsilon RI signaling pathway

1.29E-03

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Icosapent

hsa04666

Fc gamma R-mediated phagocytosis

2.66E-02

O75015, P06396, O14494, Q9UQC2, P17252

FCGR3B, GSN, PLPP1, GAB2, PRKCA

Icosapent

hsa04668

TNF signaling pathway

4.74E-02

Q99941, P01584, O95429

CREBL1, IL1B, BAG4

Icosapent

hsa04672

Intestinal immune network for IgA production

3.16E-02

P20036

HLA-DPA1

Icosapent

hsa04710

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Icosapent

hsa04714

Thermogenesis

3.64E-02

Q9UKU0

ACSL6

Icosapent

hsa04720

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Icosapent

hsa04723

Retrograde endocannabinoid signaling

1.75E-02

Q14643, P17252, P22694, Q16539, Q16718

ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5

Icosapent

hsa04724

Glutamatergic synapse

3.24E-02

P43003, P50151, P15104

SLC1A3, GNG10, GLUL

Icosapent

hsa04730

Long-term depression

1.35E-02

Q14344, P07948

GNA13, LYN

Icosapent

hsa04750

Inflammatory mediator regulation of TRP channels

8.09E-03

P01584, P51828, Q13557, Q9Y5S1

IL1B, ADCY7, CAMK2D, TRPV2

Icosapent

hsa04810

Regulation of actin cytoskeleton

2.58E-02

Q15746, P08514, P25116

MYLK, ITGA2B, F2R

Icosapent

hsa04911

Insulin secretion

1.48E-02

P51828, Q99941, Q13557

ADCY7, CREBL1, CAMK2D

Icosapent

hsa04912

GnRH signaling pathway

2.87E-04

P17252, Q16539, Q9Y6R4, Q14643, P22694

PRKCA, MAPK14, MAP3K4, ITPR1, PRKACB

Icosapent

hsa04914

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Icosapent

hsa04915

Estrogen signaling pathway

4.72E-02

Q99941, P51828, P07900, P11142

CREBL1, ADCY7, HSP90AA1, HSPA8

Icosapent

hsa04920

Adipocytokine signaling pathway

4.85E-03

Q9UKU0, Q9Y478, Q96RR4

ACSL6, PRKAB1, CAMKK2

Icosapent

hsa04925

Aldosterone synthesis and secretion

5.19E-03

Q99941, P51828, Q13557, P23634

CREBL1, ADCY7, CAMK2D, ATP2B4

Icosapent

hsa04928

Parathyroid hormone synthesis, secretion and action

3.75E-02

Q14643, P22694, P23771, P17252, P10415

ITPR1, PRKACB, GATA3, PRKCA, BCL2

Icosapent

hsa04933

AGE-RAGE signaling pathway in diabetic complications

2.11E-03

P84022, Q13485, P10415, P42338, P49767, P19174

SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1

Icosapent

hsa04934

Cushing syndrome

3.48E-03

Q99941, P51828, O15169, Q13557

CREBL1, ADCY7, AXIN1, CAMK2D

Icosapent

hsa04940

Type I diabetes mellitus

4.05E-02

P20036

HLA-DPA1

Icosapent

hsa04971

Gastric acid secretion

1.48E-02

P51828, P15311, Q13557

ADCY7, VIL2, CAMK2D

Icosapent

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Icosapent

hsa05010

Alzheimer disease

2.07E-02

Q92542, P05496, P12074, O75460, P01584, O15169, P45880

NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2

Icosapent

hsa05012

Parkinson disease

2.31E-02

P21796, P60604, Q71U36, Q13509

VDAC1, UBE2G2, TUBA1A, TUBB3

Icosapent

hsa05020

Prion disease

1.25E-03

P01584, P46531, P11142, P05496, P12074, P21796, P45880, Q71U36, Q13509, Q99941

IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC1, VDAC2, TUBA1A, TUBB3, CREBL1

Icosapent

hsa05022

Pathways of neurodegeneration - multiple diseases

4.20E-02

Q71U36, Q13509, P21796, P04628, P60604

TUBA1A, TUBB3, VDAC1, WNT1, UBE2G2

Icosapent

hsa05130

Pathogenic Escherichia coli infection

7.39E-03

Q14247, P56750, O00501, P25116

CTTN, CLDN17, CLDN5, F2R

Icosapent

hsa05132

Salmonella infection

2.04E-02

P25963, Q13489, P10415, Q9BQS8

NFKBIA, BIRC3, BCL2, FYCO1

Icosapent

hsa05133

Pertussis

2.41E-02

P09871, Q02556

C1S, IRF8

Icosapent

hsa05142

Chagas disease

4.93E-02

P04234

CD3D

Icosapent

hsa05145

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Icosapent

hsa05152

Tuberculosis

1.26E-02

Q13488, O75015, P48382, O60603, P10415, P13765, Q9UDY8, Q16539

TCIRG1, FCGR3B, RFX5, TLR2, BCL2, HLA-DOB, MALT1, MAPK14

Icosapent

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Icosapent

hsa05166

Human T-cell leukemia virus 1 infection

9.87E-03

P04234, P20036

CD3D, HLA-DPA1

Icosapent

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Icosapent

hsa05169

Epstein-Barr virus infection

3.43E-03

P20036, P04234

HLA-DPA1, CD3D

Icosapent

hsa05170

Human immunodeficiency virus 1 infection

6.02E-03

Q02750, P62879, P16298, Q05397, P20333

MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B

Icosapent

hsa05200

Pathways in cancer

9.46E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Icosapent

hsa05202

Transcriptional misregulation in cancer

1.72E-04

Q12778, Q15532, P41732, P14780, P27930, Q16548, Q13489, Q13077, O15550, P35226, P05164, P08246, Q9C0K0, P41182, P68431, P24522

FOXO1, SS18, TSPAN7, MMP9, IL1R2, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, ELA2, BCL11B, BCL6, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	Q12778	FOXO1	Forkhead box protein O1	-0.769
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15532	SS18	Protein SSXT	-0.803
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	Q15532	SS18	Protein SSXT	-0.84
Q15722	LTB4R	Leukotriene B4 receptor 1	P41732	TSPAN7	Tetraspanin-7	0.775
Q15722	LTB4R	Leukotriene B4 receptor 1	P14780	MMP9	Matrix metalloproteinase-9	0.861
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	P14780	MMP9	Matrix metalloproteinase-9	0.861
Q15722	LTB4R	Leukotriene B4 receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.734
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.778
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16548	BCL2A1	Bcl-2-related protein A1	0.837
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	Q16548	BCL2A1	Bcl-2-related protein A1	0.933
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.797
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.774
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	Q13077	TRAF1	TNF receptor-associated factor 1	-0.832
Q15722	LTB4R	Leukotriene B4 receptor 1	O15550	UTX	Lysine-specific demethylase 6A	0.789
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.802
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.802
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	P05164	MPO	Myeloperoxidase	0.7
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	P08246	ELA2	Neutrophil elastase	0.768
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.808
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	P41182	BCL6	B-cell lymphoma 6 protein	0.776
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	-0.757
Q15722	LTB4R	Leukotriene B4 receptor 1	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.764
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.712

Icosapent

hsa05206

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Icosapent

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Icosapent

hsa05212

Pancreatic cancer

4.45E-03

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Icosapent

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Icosapent

hsa05217

Basal cell carcinoma

3.30E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Icosapent

hsa05220

Chronic myeloid leukemia

1.44E-03

Q13547, Q13485, P25963, P84022, P42338, O75293

HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B

Icosapent

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Icosapent

hsa05226

Gastric cancer

4.33E-03

Q02750, O15169, P84022, Q13485, P10415

MAP2K1, AXIN1, SMAD3, SMAD4, BCL2

Icosapent

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

4.93E-02

P04234

CD3D

Icosapent

hsa05310

Asthma

2.71E-02

P20036

HLA-DPA1

Icosapent

hsa05320

Autoimmune thyroid disease

3.60E-02

P20036

HLA-DPA1

Icosapent

hsa05321

Inflammatory bowel disease

1.52E-02

O60603, P13765, P20036, Q14765, P23771

TLR2, HLA-DOB, HLA-DPA1, STAT4, GATA3

Icosapent

hsa05330

Allograft rejection

3.60E-02

P20036

HLA-DPA1

Icosapent

hsa05332

Graft-versus-host disease

8.94E-03

P13765, P20036, P10747, P26715, Q13241

HLA-DOB, HLA-DPA1, CD28, KLRC1, KLRD1

Icosapent

hsa05340

Primary immunodeficiency

1.81E-02

P04234

CD3D

Icosapent

hsa05415

Diabetic cardiomyopathy

3.07E-02

P17252, Q15080, Q16718, O14521, Q16539, P49841, P14780

PRKCA, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, MMP9

Icosapent

hsa05416

Viral myocarditis

4.49E-02

P20036

HLA-DPA1

Community members of Icosapent (S_DC: 2.88)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P49354

FNTA

Protein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alpha

Predicted

0.5303

0.7588

1.7827

P18054

ALOX12

Polyunsaturated fatty acid lipoxygenase ALOX12

Predicted

0.0075

0.3703

0.2416

0.986

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

Q15722

LTB4R

Leukotriene B4 receptor 1

Predicted

0.0677

0.2199

0.4736

O75469

NR1I2

Nuclear receptor subfamily 1 group I member 2

Predicted

0.0315

0.9493

1.9143

P35610

SOAT1

Sterol ONoneacyltransferase 1

Predicted

0.3855

0.2936

0.0165

0.7964

Q9Y5S1

TRPV2

Transient receptor potential cation channel subfamily V member 2

Predicted

0.6291

0.0388

0.2402

0.6324

P33121

ACSL1

LongNonechainNonefattyNoneacidNoneNoneCoA ligase 1

Predicted

0.0373

0.0132

0.2709

0.3161

Q9UKU0

ACSL6

LongNonechainNonefattyNoneacidNoneNoneCoA ligase 6

Predicted

0.4581

0.0111

0.2709

0.5222

P10826

RARB

Retinoic acid receptor beta

Predicted

0.0094

0.3466

0.3005

0.9983

O14843

FFAR3

Free fatty acid receptor 3

Predicted

0.0127

0.0065

0.0193

PharmaCoNets of Icosapent (SPCN: 41.61 )

Icosapent regulated-network (SDN: 14.45)

Community members of Icosapent (SDC: 2.88)

PharmaCoNets of Icosapent (S_PCN: 41.61 )

Icosapent regulated-network (S_DN: 14.45)

Community members of Icosapent (S_DC: 2.88)