PharmaCoNets of Ibrutinib (SPCN: 280.87 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ibrutinibhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Ibrutinibhsa00030Pentose phosphate pathway1.77E-044P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Ibrutinibhsa00040Pentose and glucuronate interconversions4.00E-021P15121AKR1B1More
Ibrutinibhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Ibrutinibhsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Ibrutinibhsa00190Oxidative phosphorylation9.21E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Ibrutinibhsa00220Arginine biosynthesis6.43E-053P15104, P05089, P49448GLUL, ARG1, GLUD2More
Ibrutinibhsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Ibrutinibhsa00310Lysine degradation3.15E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Ibrutinibhsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Ibrutinibhsa00471D-Glutamine and D-glutamate metabolism3.98E-021Q7Z3D6C14orf159More
Ibrutinibhsa00500Starch and sucrose metabolism4.63E-054O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Ibrutinibhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Ibrutinibhsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Ibrutinibhsa00520Amino sugar and nucleotide sugar metabolism2.11E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Ibrutinibhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Ibrutinibhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Ibrutinibhsa00591Linoleic acid metabolism1.34E-031P11712CYP2C9More
Ibrutinibhsa00600Sphingolipid metabolism2.65E-033Q9BX95, Q06136, P15289SGPP1, FVT1, ARSAMore
Ibrutinibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Ibrutinibhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Ibrutinibhsa00630Glyoxylate and dicarboxylate metabolism3.36E-114P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Ibrutinibhsa00670One carbon pool by folate1.33E-022P04818, Q99707TYMS, MTRMore
Ibrutinibhsa00730Thiamine metabolism4.07E-022P05186, P24666ALPL, ACP1More
Ibrutinibhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Ibrutinibhsa00770Pantothenate and CoA biosynthesis2.82E-053O95498, Q6ZQY3, Q9NRN7VNN2, GADL1, AASDHPPTMore
Ibrutinibhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Ibrutinibhsa00790Folate biosynthesis2.02E-021P15121AKR1B1More
Ibrutinibhsa00830Retinol metabolism2.27E-035P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Ibrutinibhsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Ibrutinibhsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Ibrutinibhsa00970Aminoacyl-tRNA biosynthesis7.84E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Ibrutinibhsa00980Metabolism of xenobiotics by cytochrome P4507.66E-063P78417, P09211, P11712GSTO1, GSTP1, CYP2C9More
Ibrutinibhsa00982Drug metabolism - cytochrome P4501.04E-042P11712, P78417CYP2C9, GSTO1More
Ibrutinibhsa00983Drug metabolism - other enzymes1.81E-034P04183, P20839, P32320, P05164TK1, IMPDH1, CDA, MPOMore
Ibrutinibhsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Ibrutinibhsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Ibrutinibhsa01230Biosynthesis of amino acids1.86E-047P51854, P60891, Q99707, P50213, P05089, P15104, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, GLUL, TALDO1More
Ibrutinibhsa01240Biosynthesis of cofactors2.95E-022P13716, P14618ALAD, PKM2More
Ibrutinibhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Ibrutinibhsa01522Endocrine resistance7.78E-045P04049, Q9UM47, P08069, P10415, Q13323RAF1, NOTCH3, IGF1R, BCL2, BIKMore
Ibrutinibhsa01523Antifolate resistance1.43E-032Q92820, P04818GGH, TYMSMore
Ibrutinibhsa01524Platinum drug resistance4.95E-033P78417, P52701, P31751GSTO1, MSH6, AKT2More
Ibrutinibhsa02010ABC transporters2.17E-031Q8IZY2ABCA7More
Ibrutinibhsa03010Ribosome2.25E-045P40429, Q07020, P27635, P05386, P62249RPL13A, RPL18, RPL10, RPLP1, RPS16More
Ibrutinibhsa03013RNA transport3.00E-0614P62826, P52298, O14893, Q15287, Q9UBU9, P35658, P63279, P68104, O14602, P55884, O15371, P78345, Q9H777, P20042RAN, NCBP2, GEMIN2, RNPS1, NXF1, NUP214, UBE2I, EEF1A1, EIF1AY, EIF3B, EIF3D, RPP38, ELAC1, EIF2S2More
Ibrutinibhsa03022Basal transcription factors3.52E-033O00268, Q5H9L4, Q15544TAF4, TAF7L, TAF11More
Ibrutinibhsa03040Spliceosome6.30E-1019Q14562, O43143, O60508, P17844, P08579, Q15427, P26368, P51991, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, DDX5, SNRPB2, SF3B4, U2AF2, HNRPA3, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Ibrutinibhsa03050Proteasome3.30E-021P55036PSMD4More
Ibrutinibhsa03060Protein export1.43E-022P37108, Q15005SRP14, SPCS2More
Ibrutinibhsa03430Mismatch repair4.38E-021P20585MSH3More
Ibrutinibhsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Ibrutinibhsa04010MAPK signaling pathway1.69E-032P04049, P08069RAF1, IGF1RMore
Ibrutinibhsa04012ErbB signaling pathway6.03E-047P21860, P16333, Q13557, P19174, O14944, P01106, P04049ERBB3, NCK1, CAMK2D, PLCG1, EREG, MYC, RAF1More
Ibrutinibhsa04014Ras signaling pathway1.74E-049P04049, P31751, P42338, P20827, P49767, P08069, Q13009, P0DP23, P50151RAF1, AKT2, PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, CALM1, GNG10More
Ibrutinibhsa04015Rap1 signaling pathway3.20E-076P04049, P08069, P06213, O00522, P31751, P0DP23RAF1, IGF1R, INSR, KRIT1, AKT2, CALM1More
Ibrutinibhsa04020Calcium signaling pathway2.16E-0611Q96DU7, Q08828, P21796, P45880, Q13557, P21860, P30679, P0DP24, P05141, P51828, P23634ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, ERBB3, GNA15, CALM2, SLC25A5, ADCY7, ATP2B4More
Ibrutinibhsa04022cGMP-PKG signaling pathway1.54E-0412Q02153, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Ibrutinibhsa04024cAMP signaling pathway4.48E-046P42338, P31751, P0DP23, P04049, Q13370, Q13009PIK3CB, AKT2, CALM1, RAF1, PDE3B, TIAM1More
Ibrutinibhsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Ibrutinibhsa04061Viral protein interaction with cytokine and cytokine receptor7.78E-0510P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P09603, P01375CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, CSF1, TNFMore
Ibrutinibhsa04062Chemokine signaling pathway2.53E-0516P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, P22694, P04049, P49841CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, PRKACB, RAF1, GSK3BMore
Ibrutinibhsa04064NF-kappa B signaling pathway5.53E-1421P10415, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643, Q9NQC7BCL2, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB, CYLDMore
Ibrutinibhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Ibrutinibhsa04068FoxO signaling pathway3.80E-042P04049, P08069RAF1, IGF1RMore
Ibrutinibhsa04070Phosphatidylinositol signaling system3.21E-035P0DP23, P42338, Q86XP1, P27987, Q96DU7CALM1, PIK3CB, DGKH, ITPKB, ITPKCMore
Ibrutinibhsa04071Sphingolipid signaling pathway1.04E-037P04049, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415RAF1, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Ibrutinibhsa04072Phospholipase D signaling pathway2.31E-026P04049, P42338, P43657, P25024, P25025, P19174RAF1, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Ibrutinibhsa04080Neuroactive ligand-receptor interaction3.22E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1More
Ibrutinibhsa04110Cell cycle2.12E-069Q9UBD5, P06493, O60566, Q14683, O75293, P30304, P33981, P42773, P01106ORC3, CDK1, BUB1B, SMC1A, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Ibrutinibhsa04114Oocyte meiosis7.29E-036Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1RMore
Ibrutinibhsa04115p53 signaling pathway3.63E-036P24522, O15151, Q13315, Q53FA7, O95067, P10415GADD45A, MDM4, ATM, TP53I3, CCNB2, BCL2More
Ibrutinibhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Ibrutinibhsa04140Autophagy - animal1.64E-049P08069, Q9Y4H2, P04049, Q9NQL2, P22694, Q14643, P10415, Q9H1Y0, Q04759IGF1R, IRS2, RAF1, RRAGD, PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Ibrutinibhsa04141Protein processing in endoplasmic reticulum6.22E-059P18848, Q15437, Q15436, Q99941, O75460, P11142, Q9H3Z4, P07900, Q9NR31ATF4, SEC23B, SEC23A, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, SAR1AMore
Ibrutinibhsa04142Lysosome2.64E-022Q99437, P25774ATP6V0B, CTSSMore
Ibrutinibhsa04144Endocytosis2.81E-026Q13191, P11142, P25024, P43250, P14784, Q9Y5X3CBLB, HSPA8, CXCR1, GRK6, IL2RB, SNX5More
Ibrutinibhsa04145Phagosome3.59E-0312O75015, Q15080, P14598, Q13509, P68371, Q99437, P05164, P78380, O60603, P35443, P13765, P25774FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Ibrutinibhsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Ibrutinibhsa04151PI3K-Akt signaling pathway2.00E-0519P62753, P42338, P21860, P43657, P27348, P20827, P49767, P07900, P62873, P50151, P61952, O15335, Q16363, Q13751, P22105, P14784, Q99941, P18848, O00141RPS6, PIK3CB, ERBB3, P2RY5, YWHAQ, EFNA1, VEGFC, HSP90AA1, GNB1, GNG10, GNG11, CHAD, LAMA4, LAMB3, TNXB, IL2RB, CREBL1, ATF4, SGKMore
Ibrutinibhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Ibrutinibhsa04210Apoptosis4.14E-039Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643, P04049ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1, RAF1More
Ibrutinibhsa04211Longevity regulating pathway5.33E-034P08069, P51828, Q99941, P18848IGF1R, ADCY7, CREBL1, ATF4More
Ibrutinibhsa04213Longevity regulating pathway - multiple species1.17E-025P42338, P08069, Q9Y4H2, P11142, Q13547PIK3CB, IGF1R, IRS2, HSPA8, HDAC1More
Ibrutinibhsa04217Necroptosis2.39E-0619P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q13557, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CAMK2D, CHMP2A, PPIDMore
Ibrutinibhsa04218Cellular senescence3.00E-047P01106, P31751, P04049, O75293, P30304, P06493, P0DP23MYC, AKT2, RAF1, GADD45B, CDC25A, CDK1, CALM1More
Ibrutinibhsa04261Adrenergic signaling in cardiomyocytes1.15E-047P51828, P31751, Q99941, P18848, P0DP23, Q13557, P23634ADCY7, AKT2, CREBL1, ATF4, CALM1, CAMK2D, ATP2B4More
Ibrutinibhsa04270Vascular smooth muscle contraction2.75E-033P04049, P35579, P35318RAF1, MYH9, ADMMore
Ibrutinibhsa04310Wnt signaling pathway5.60E-033P30279, Q13485, O43318CCND2, SMAD4, MAP3K7More
Ibrutinibhsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Ibrutinibhsa04340Hedgehog signaling pathway3.93E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Ibrutinibhsa04360Axon guidance5.32E-035P20827, O95631, P42338, P23528, P04049EFNA1, NTN1, PIK3CB, CFL1, RAF1More
Ibrutinibhsa04370VEGF signaling pathway1.99E-045P16298, P31751, Q05397, Q02750, P04049PPP3CB, AKT2, PTK2, MAP2K1, RAF1More
Ibrutinibhsa04371Apelin signaling pathway1.09E-038P62873, P61952, P31751, P04049, Q08828, P62753, P0DP24, P0DP23GNB1, GNG11, AKT2, RAF1, ADCY1, RPS6, CALM2, CALM1More
Ibrutinibhsa04380Osteoclast differentiation1.35E-0413Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Ibrutinibhsa04390Hippo signaling pathway5.79E-034P04628, Q9UJU2, O43623, Q13489WNT1, LEF1, SNAI2, BIRC3More
Ibrutinibhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Ibrutinibhsa04510Focal adhesion1.63E-035Q15942, P51636, P30281, P04049, P08069ZYX, CAV2, CCND3, RAF1, IGF1RMore
Ibrutinibhsa04512ECM-receptor interaction1.90E-022P26012, P16070ITGB8, CD44More
Ibrutinibhsa04520Adherens junction1.81E-033Q13485, O43318, P08069SMAD4, MAP3K7, IGF1RMore
Ibrutinibhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Ibrutinibhsa04540Gap junction8.97E-044Q13509, P68371, P04049, Q9NRA1TUBB3, TUBB2C, RAF1, PDGFCMore
Ibrutinibhsa04550Signaling pathways regulating pluripotency of stem cells3.80E-042P04049, P08069RAF1, IGF1RMore
Ibrutinibhsa04610Complement and coagulation cascades4.27E-061P0C0L4C4AMore
Ibrutinibhsa04612Antigen processing and presentation1.92E-058P13765, P48382, P01730, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Ibrutinibhsa04613Neutrophil extracellular trap formation7.84E-0522P04049, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539RAF1, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Ibrutinibhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Ibrutinibhsa04620Toll-like receptor signaling pathway4.78E-021P31751AKT2More
Ibrutinibhsa04621NOD-like receptor signaling pathway1.89E-0211Q16539, Q14643, P21796, P10599, Q9H1Y0, P43490, O00463, P29728, P01375, P09341, P12838MAPK14, ITPR1, VDAC1, TXN, ATG5, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4More
Ibrutinibhsa04622RIG-I-like receptor signaling pathway1.81E-021Q9NQC7CYLDMore
Ibrutinibhsa04623Cytosolic DNA-sensing pathway4.01E-043P01568, Q13546, P25963IFNA21, RIPK1, NFKBIAMore
Ibrutinibhsa04625C-type lectin receptor signaling pathway3.02E-0512Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Ibrutinibhsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Ibrutinibhsa04640Hematopoietic cell lineage2.82E-1118P13612, P21926, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P09603, P01584ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, CSF1, IL1BMore
Ibrutinibhsa04650Natural killer cell mediated cytotoxicity4.57E-1114P19174, P01375, P78314, P06239, O60880, P20963, P42338, P04049, Q13241, P26718, O14931, O75015, P26717, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Ibrutinibhsa04657IL-17 signaling pathway2.25E-038O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Ibrutinibhsa04658Th1 and Th2 cell differentiation7.36E-2215Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Ibrutinibhsa04659Th17 cell differentiation2.97E-1720Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, Q13485, P01584, P08238, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Ibrutinibhsa04660T cell receptor signaling pathway7.04E-1818P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Ibrutinibhsa04662B cell receptor signaling pathway9.96E-097P31751, P42338, P60033, P07948, P21854, Q8N149, P04049AKT2, PIK3CB, CD81, LYN, CD72, LILRA2, RAF1More
Ibrutinibhsa04664Fc epsilon RI signaling pathway1.18E-067P31751, P42338, Q9UQC2, P07948, P04049, P09917, P20292AKT2, PIK3CB, GAB2, LYN, RAF1, ALOX5, ALOX5APMore
Ibrutinibhsa04666Fc gamma R-mediated phagocytosis1.31E-024P42338, P04049, P23528, P14598PIK3CB, RAF1, CFL1, NCF1More
Ibrutinibhsa04668TNF signaling pathway1.29E-035Q99941, P18848, P01584, P20333, O95429CREBL1, ATF4, IL1B, TNFRSF1B, BAG4More
Ibrutinibhsa04672Intestinal immune network for IgA production1.66E-023P10747, P13765, P13612CD28, HLA-DOB, ITGA4More
Ibrutinibhsa04713Circadian entrainment4.35E-046P0DP24, Q13557, Q02153, P62873, P61952, Q08828CALM2, CAMK2D, GUCY1B3, GNB1, GNG11, ADCY1More
Ibrutinibhsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Ibrutinibhsa04720Long-term potentiation7.71E-035Q13557, P0DP24, P18848, Q08828, P04049CAMK2D, CALM2, ATF4, ADCY1, RAF1More
Ibrutinibhsa04721Synaptic vesicle cycle9.45E-042Q13488, P31645TCIRG1, SLC6A4More
Ibrutinibhsa04722Neurotrophin signaling pathway3.42E-058P31751, P04049, P49841, O43524, P48023, P51617, P10415, P0DP23AKT2, RAF1, GSK3B, FOXO3, FASLG, IRAK1, BCL2, CALM1More
Ibrutinibhsa04723Retrograde endocannabinoid signaling4.82E-039Q14643, P62873, P63218, P50151, P61952, Q08828, P22694, Q16539, O15239ITPR1, GNB1, GNG5, GNG10, GNG11, ADCY1, PRKACB, MAPK14, NDUFA1More
Ibrutinibhsa04724Glutamatergic synapse2.69E-068O15399, P43003, Q08828, P62873, P63218, P50151, P61952, P15104GRIN2D, SLC1A3, ADCY1, GNB1, GNG5, GNG10, GNG11, GLULMore
Ibrutinibhsa04725Cholinergic synapse1.42E-0512Q08828, P51828, P22694, Q14643, P62873, P63218, P50151, P61952, P18848, Q13557, P42338, P10415ADCY1, ADCY7, PRKACB, ITPR1, GNB1, GNG5, GNG10, GNG11, ATF4, CAMK2D, PIK3CB, BCL2More
Ibrutinibhsa04726Serotonergic synapse1.33E-021P04049RAF1More
Ibrutinibhsa04727GABAergic synapse5.49E-057Q08828, P62873, P63218, P50151, P61952, P15104, Q15111ADCY1, GNB1, GNG5, GNG10, GNG11, GLUL, PLCL1More
Ibrutinibhsa04728Dopaminergic synapse3.41E-0614P62873, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, P0DP24, P0DP23, O15516, P48058GNB1, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, CALM2, CALM1, CLOCK, GRIA4More
Ibrutinibhsa04730Long-term depression1.25E-042P08069, P04049IGF1R, RAF1More
Ibrutinibhsa04740Olfactory transduction4.52E-054P62873, Q13557, P0DP23, P0DP24GNB1, CAMK2D, CALM1, CALM2More
Ibrutinibhsa04744Phototransduction3.18E-053P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Ibrutinibhsa04750Inflammatory mediator regulation of TRP channels2.83E-0713P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2More
Ibrutinibhsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Ibrutinibhsa04910Insulin signaling pathway2.40E-053P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Ibrutinibhsa04911Insulin secretion8.91E-075Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Ibrutinibhsa04912GnRH signaling pathway3.22E-039P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP24, P22694, P04049ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB, RAF1More
Ibrutinibhsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Ibrutinibhsa04914Progesterone-mediated oocyte maturation2.77E-049P08069, Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750, P04049IGF1R, CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Ibrutinibhsa04915Estrogen signaling pathway1.14E-0614P14780, P22694, P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P11142, Q14643, P0DP24, P0DP23, P10415MMP9, PRKACB, RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA8, ITPR1, CALM2, CALM1, BCL2More
Ibrutinibhsa04916Melanogenesis1.47E-032P0DP23, P04049CALM1, RAF1More
Ibrutinibhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Ibrutinibhsa04918Thyroid hormone synthesis6.21E-057P22694, Q08828, P51828, Q99941, P18848, Q14643, P02768PRKACB, ADCY1, ADCY7, CREBL1, ATF4, ITPR1, ALBMore
Ibrutinibhsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Ibrutinibhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Ibrutinibhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Ibrutinibhsa04922Glucagon signaling pathway4.86E-044P14618, P06737, P31751, P0DP23PKM2, PYGL, AKT2, CALM1More
Ibrutinibhsa04923Regulation of lipolysis in adipocytes6.26E-045P07550, P06213, P42338, Q9Y4H2, P31751ADRB2, INSR, PIK3CB, IRS2, AKT2More
Ibrutinibhsa04924Renin secretion8.89E-045P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Ibrutinibhsa04925Aldosterone synthesis and secretion7.32E-077Q99941, P18848, Q08828, P51828, P0DP24, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4More
Ibrutinibhsa04926Relaxin signaling pathway2.31E-0613P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P49767, Q08828, P51828, P04049, P30679, P49407PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, GNA15, ARRB1More
Ibrutinibhsa04927Cortisol synthesis and secretion2.07E-066Q14643, Q99941, P18848, Q08828, P51828, P22694ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACBMore
Ibrutinibhsa04928Parathyroid hormone synthesis, secretion and action6.67E-048Q14643, P51828, P22694, P23771, P04049, Q99941, P18848, P10415ITPR1, ADCY7, PRKACB, GATA3, RAF1, CREBL1, ATF4, BCL2More
Ibrutinibhsa04929GnRH secretion2.28E-044P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Ibrutinibhsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Ibrutinibhsa04932Non-alcoholic fatty liver disease3.08E-038P01375, P49841, P18848, P48023, P01584, P13073, P12074, O15239TNF, GSK3B, ATF4, FASLG, IL1B, COX4I1, COX6A1, NDUFA1More
Ibrutinibhsa04934Cushing syndrome1.66E-066Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Ibrutinibhsa04935Growth hormone synthesis, secretion and action5.33E-034P51828, P04049, Q99941, P18848ADCY7, RAF1, CREBL1, ATF4More
Ibrutinibhsa04940Type I diabetes mellitus2.17E-034P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Ibrutinibhsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Ibrutinibhsa04962Vasopressin-regulated water reabsorption7.22E-032P52566, P62491ARHGDIB, RAB11AMore
Ibrutinibhsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Ibrutinibhsa04966Collecting duct acid secretion2.17E-031P00918CA2More
Ibrutinibhsa04970Salivary secretion1.48E-038P07550, Q08828, P22694, Q14643, P0DP24, P0DP23, Q02153, P49913ADRB2, ADCY1, PRKACB, ITPR1, CALM2, CALM1, GUCY1B3, CAMPMore
Ibrutinibhsa04971Gastric acid secretion2.57E-034P51828, P15311, P0DP23, Q13557ADCY7, VIL2, CALM1, CAMK2DMore
Ibrutinibhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Ibrutinibhsa04975Fat digestion and absorption4.83E-021O14494PLPP1More
Ibrutinibhsa05010Alzheimer disease7.84E-0410Q92542, P05496, P12074, Q00535, O75460, P0DP23, P01584, O15169, P31751, P45880NCSTN, ATP5G1, COX6A1, CDK5, ERN1, CALM1, IL1B, AXIN1, AKT2, VDAC2More
Ibrutinibhsa05012Parkinson disease4.13E-028O15239, P13073, P12074, P05496, P05141, P18848, P0DP24, Q13557NDUFA1, COX4I1, COX6A1, ATP5G1, SLC25A5, ATF4, CALM2, CAMK2DMore
Ibrutinibhsa05017Spinocerebellar ataxia1.93E-035Q92915, Q8TB72, O15399, P42338, P21796FGF14, PUM2, GRIN2D, PIK3CB, VDAC1More
Ibrutinibhsa05020Prion disease1.16E-0311P01584, P46531, P11142, O15239, P05496, P13073, P12074, P18848, P05141, P45880, Q99941IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX4I1, COX6A1, ATF4, SLC25A5, VDAC2, CREBL1More
Ibrutinibhsa05022Pathways of neurodegeneration - multiple diseases1.60E-034Q06055, Q00535, O15020, P0DP23ATP5G2, CDK5, SPTBN2, CALM1More
Ibrutinibhsa05030Cocaine addiction6.96E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Ibrutinibhsa05031Amphetamine addiction5.03E-055P0DP24, P0DP23, Q13557, Q99941, P18848CALM2, CALM1, CAMK2D, CREBL1, ATF4More
Ibrutinibhsa05034Alcoholism3.82E-0613Q99941, P18848, P0DP24, Q96RR4, P62873, P61952, P04049, P0C0S5, Q93077, P62807, O60814, P84243, P68431CREBL1, ATF4, CALM2, CAMKK2, GNB1, GNG11, RAF1, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Ibrutinibhsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Ibrutinibhsa05120Epithelial cell signaling in Helicobacter pylori infection2.13E-099Q16539, Q99437, P09341, P19875, P19174, P25024, P25025, P41240, P07948MAPK14, ATP6V0B, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, CSK, LYNMore
Ibrutinibhsa05131Shigellosis3.40E-0317P01375, O00463, Q13546, P14778, Q16539, Q04759, Q9UDY8, P61088, Q9NQL2, Q9H1Y0, P12814, Q14643, Q12778, P49841, Q13315, P10415, P21796TNF, TRAF5, RIPK1, IL1R1, MAPK14, PRKCQ, MALT1, UBE2N, RRAGD, ATG5, ACTN1, ITPR1, FOXO1, GSK3B, ATM, BCL2, VDAC1More
Ibrutinibhsa05132Salmonella infection1.72E-0611P51617, P04049, Q9UJU2, Q13546, Q13489, P10415, O75369, Q9BQS8, Q13561, Q13509, P68371IRAK1, RAF1, LEF1, RIPK1, BIRC3, BCL2, FLNB, FYCO1, DCTN2, TUBB3, TUBB2CMore
Ibrutinibhsa05133Pertussis3.02E-031P0C0L4C4AMore
Ibrutinibhsa05134Legionellosis8.12E-047P01584, Q9NR31, P11215, P68104, P11142, P09341, P19875IL1B, SAR1A, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2More
Ibrutinibhsa05140Leishmaniasis3.62E-0714P13612, O75015, P14598, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, NCF4More
Ibrutinibhsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Ibrutinibhsa05144Malaria2.02E-058P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1More
Ibrutinibhsa05146Amoebiasis3.89E-1313P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Ibrutinibhsa05150Staphylococcus aureus infection1.31E-022P0C0L4, P13646C4A, KRT13More
Ibrutinibhsa05152Tuberculosis1.30E-059P04049, Q99437, P0DP23, P48382, P31751, P10415, P25774, Q9UDY8, P51617RAF1, ATP6V0B, CALM1, RFX5, AKT2, BCL2, CTSS, MALT1, IRAK1More
Ibrutinibhsa05160Hepatitis C1.58E-047P52630, P60033, Q9NZJ5, P04049, P49841, P01375, P48023STAT2, CD81, EIF2AK3, RAF1, GSK3B, TNF, FASLGMore
Ibrutinibhsa05161Hepatitis B5.33E-034P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Ibrutinibhsa05163Human cytomegalovirus infection6.40E-0623P31751, P04049, P01375, P62873, P63218, P50151, P61952, Q14643, P0DP24, P0DP23, Q08828, P22694, P49841, P14778, P01584, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P61769AKT2, RAF1, TNF, GNB1, GNG5, GNG10, GNG11, ITPR1, CALM2, CALM1, ADCY1, PRKACB, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, B2MMore
Ibrutinibhsa05164Influenza A3.65E-021P04049RAF1More
Ibrutinibhsa05167Kaposi sarcoma-associated herpesvirus infection2.62E-043P31751, P04049, P0DP23AKT2, RAF1, CALM1More
Ibrutinibhsa05168Herpes simplex virus 1 infection1.38E-0415P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P42338, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PIK3CB, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212More
Ibrutinibhsa05169Epstein-Barr virus infection1.21E-0517P13765, P01106, Q13547, O00463, P10415, Q16539, P42338, P07948, Q13761, P24522, O75293, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, BCL2, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Ibrutinibhsa05170Human immunodeficiency virus 1 infection1.51E-047P31751, P04049, P62873, P0DP23, P51617, P10415, Q9Y6Q5AKT2, RAF1, GNB1, CALM1, IRAK1, BCL2, AP1M2More
Ibrutinibhsa05171Coronavirus disease - COVID-193.87E-045P62249, P40429, P27635, Q07020, P05386RPS16, RPL13A, RPL10, RPL18, RPLP1More
Ibrutinibhsa05200Pathways in cancer6.29E-0520P42338, P08238, P42224, Q9UJU2, P43246, Q13485, P52701, P14923, P30279, P10415, Q13077, P31751, P62873, P63218, Q9UM47, P78417, O75293, P0DP23, P14784, P40189PIK3CB, HSP90AB1, STAT1, LEF1, MSH2, SMAD4, MSH6, JUP, CCND2, BCL2, TRAF1, AKT2, GNB1, GNG5, NOTCH3, GSTO1, GADD45B, CALM1, IL2RB, IL6STMore
Ibrutinibhsa05202Transcriptional misregulation in cancer8.35E-0821Q15532, Q13315, P41732, P17844, P14780, P27930, Q15744, Q16548, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Ibrutinibhsa05203Viral carcinogenesis2.23E-047Q99941, P18848, P27348, Q15283, P61978, P62807, O60814CREBL1, ATF4, YWHAQ, RASA2, HNRPK, HIST1H2BC, H2BC12More
Ibrutinibhsa05204Chemical carcinogenesis2.29E-053P09211, P78417, P11712GSTP1, GSTO1, CYP2C9More
Ibrutinibhsa05205Proteoglycans in cancer2.26E-036Q13009, Q12955, O75369, P04049, P08069, P08962TIAM1, ANK3, FLNB, RAF1, IGF1R, CD63More
Ibrutinibhsa05206MicroRNAs in cancer6.19E-047P15311, P21860, P61978, P46531, P63279, P22105, P04049VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RAF1More
Ibrutinibhsa05210Colorectal cancer4.39E-033Q13485, P04049, P52701SMAD4, RAF1, MSH6More
Ibrutinibhsa05211Renal cell carcinoma1.29E-032P31751, P04049AKT2, RAF1More
Ibrutinibhsa05212Pancreatic cancer3.96E-045P42338, P31751, P04049, P42224, O75293PIK3CB, AKT2, RAF1, STAT1, GADD45BMore
Ibrutinibhsa05213Endometrial cancer8.16E-042P31751, P04049AKT2, RAF1More
Ibrutinibhsa05214Glioma1.37E-066P08069, P0DP23, P04049, P42338, P31751, O75293IGF1R, CALM1, RAF1, PIK3CB, AKT2, GADD45BMore
Ibrutinibhsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Ibrutinibhsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Ibrutinibhsa05217Basal cell carcinoma7.91E-035Q13635, P04628, P49841, Q9UJU2, P24522PTCH1, WNT1, GSK3B, LEF1, GADD45AMore
Ibrutinibhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Ibrutinibhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Ibrutinibhsa05220Chronic myeloid leukemia9.63E-042P31751, P04049AKT2, RAF1More
Ibrutinibhsa05221Acute myeloid leukemia8.16E-042P31751, P04049AKT2, RAF1More
Ibrutinibhsa05222Small cell lung cancer4.78E-021P31751AKT2More
Ibrutinibhsa05223Non-small cell lung cancer3.89E-055P31751, P10826, P04049, Q9HC35, O75293AKT2, RARB, RAF1, EML4, GADD45BMore
Ibrutinibhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Ibrutinibhsa05225Hepatocellular carcinoma1.99E-045P04049, P08069, Q92922, P78417, Q9NPI1RAF1, IGF1R, SMARCC1, GSTO1, BRD7More
Ibrutinibhsa05226Gastric cancer6.81E-042P04049, P31751RAF1, AKT2More
Ibrutinibhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Ibrutinibhsa05231Choline metabolism in cancer4.44E-034P04049, Q9Y259, P19174, P49619RAF1, CHKB, PLCG1, DGKGMore
Ibrutinibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.52E-1215P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, O60603, P10747, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Ibrutinibhsa05310Asthma2.47E-053P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Ibrutinibhsa05321Inflammatory bowel disease1.95E-128O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Ibrutinibhsa05322Systemic lupus erythematosus1.73E-055P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Ibrutinibhsa05323Rheumatoid arthritis8.82E-045P01375, P13765, P10747, P09341, O60603TNF, HLA-DOB, CD28, CXCL1, TLR2More
Ibrutinibhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Ibrutinibhsa05332Graft-versus-host disease6.03E-116P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Ibrutinibhsa05340Primary immunodeficiency1.31E-045P01730, P01732, P11912, P07766, P06239CD4, CD8A, CD79A, CD3E, LCKMore
Ibrutinibhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Ibrutinibhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Ibrutinibhsa05415Diabetic cardiomyopathy1.07E-026P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore
Ibrutinibhsa05418Fluid shear stress and atherosclerosis3.11E-0411Q16539, P31751, P42338, P14598, P10599, P14780, P04637, P14778, P27930, P0DP23, P08238MAPK14, AKT2, PIK3CB, NCF1, TXN, MMP9, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Ibrutinib (SDC: 10.09)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
Q9NZJ5EIF2AK3Eukaryotic translation initiation factor 2Nonealpha kinase 3Predicted10.09390.15740.63981.0015
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q9UM07PADI4ProteinNonearginine deiminase typeNone4Predicted10.14880.27780.42671.0567
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
Q16875PFKFB36NonephosphofructoNone2Nonekinase/fructoseNone2,6Nonebisphosphatase 3Predicted10.04620.08860.23420.4345
P09211GSTP1Glutathione SNonetransferase PPredicted00.32040.35230.45661.3213
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P35610SOAT1Sterol ONoneacyltransferase 1Predicted10.38550.29360.01650.7964
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q9NPI1BRD7BromodomainNonecontaining protein 7Predicted00.03190.02750.12130.1923
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P20292ALOX5APArachidonate 5NonelipoxygenaseNoneactivating proteinPredicted00.13030.24180.09070.6395
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)