PharmaCoNets of Hyoscyamine (SPCN: 66.90 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Hyoscyaminehsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Hyoscyaminehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Hyoscyaminehsa00190Oxidative phosphorylation2.97E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Hyoscyaminehsa00230Purine metabolism1.19E-035Q7LG56, P31350, P21589, P20839, Q02153RRM2B, RRM2, NT5E, IMPDH1, GUCY1B3More
Hyoscyaminehsa00240Pyrimidine metabolism1.86E-065Q7LG56, P31350, P21589, P04183, P04818RRM2B, RRM2, NT5E, TK1, TYMSMore
Hyoscyaminehsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Hyoscyaminehsa00480Glutathione metabolism3.85E-022Q7LG56, P31350RRM2B, RRM2More
Hyoscyaminehsa00565Ether lipid metabolism3.00E-031Q8N661TMEM86BMore
Hyoscyaminehsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Hyoscyaminehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Hyoscyaminehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Hyoscyaminehsa00983Drug metabolism - other enzymes6.98E-054P04183, Q7LG56, P31350, P05164TK1, RRM2B, RRM2, MPOMore
Hyoscyaminehsa01230Biosynthesis of amino acids3.91E-023P51854, Q99707, P50213TKTL1, MTR, IDH3AMore
Hyoscyaminehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Hyoscyaminehsa03008Ribosome biogenesis in eukaryotes8.16E-033Q9NYH9, P78345, Q9GZY0UTP6, RPP38, NXF2; NXF2BMore
Hyoscyaminehsa03013RNA transport3.98E-029P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Hyoscyaminehsa03015mRNA surveillance pathway3.37E-023O43148, Q9GZY0, P52298RNMT, NXF2; NXF2B, NCBP2More
Hyoscyaminehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Hyoscyaminehsa03040Spliceosome4.19E-025Q14562, O60508, P08579, Q01130, O43447DHX8, CDC40, SNRPB2, SFRS2, PPIHMore
Hyoscyaminehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Hyoscyaminehsa04064NF-kappa B signaling pathway1.09E-0411P10415, Q13489, O00463, Q13546, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341, Q9UNE0BCL2, BIRC3, TRAF5, RIPK1, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1, EDARMore
Hyoscyaminehsa04071Sphingolipid signaling pathway1.19E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Hyoscyaminehsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Hyoscyaminehsa04115p53 signaling pathway1.74E-034Q7LG56, P31350, Q9HA38, P04637RRM2B, RRM2, ZMAT3, TP53More
Hyoscyaminehsa04120Ubiquitin mediated proteolysis2.51E-036Q14145, Q13042, P62837, Q15751, O95071, P0CG47KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBBMore
Hyoscyaminehsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Hyoscyaminehsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Hyoscyaminehsa04145Phagosome2.69E-049Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Hyoscyaminehsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Hyoscyaminehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Hyoscyaminehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Hyoscyaminehsa04217Necroptosis1.85E-037P01375, P01568, P48023, Q13489, Q13546, Q14765, Q99878TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT4, H2AC14More
Hyoscyaminehsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Hyoscyaminehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Hyoscyaminehsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Hyoscyaminehsa04613Neutrophil extracellular trap formation1.55E-0418P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q93077, P58876, Q16778, O60814, P68431, Q15080, P20160, P08311, P21730, O43315, Q16539ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, C5AR1, AQP9, MAPK14More
Hyoscyaminehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Hyoscyaminehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Hyoscyaminehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Hyoscyaminehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Hyoscyaminehsa04650Natural killer cell mediated cytotoxicity2.96E-026O60880, P20963, Q13241, P26718, P26717, P26715SH2D1A, CD247, KLRD1, KLRK1, KLRC2, KLRC1More
Hyoscyaminehsa04658Th1 and Th2 cell differentiation1.07E-037Q04759, P20963, P09693, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, STAT4, GATA3, TBX21, HLA-DOBMore
Hyoscyaminehsa04659Th17 cell differentiation1.90E-026Q04759, P13765, Q9UL17, P23771, P09693, P20963PRKCQ, HLA-DOB, TBX21, GATA3, CD3G, CD247More
Hyoscyaminehsa04660T cell receptor signaling pathway1.00E-027Q9UDY8, Q04759, P10747, Q08881, P20963, P09693, P01732MALT1, PRKCQ, CD28, ITK, CD247, CD3G, CD8AMore
Hyoscyaminehsa04662B cell receptor signaling pathway1.49E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Hyoscyaminehsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Hyoscyaminehsa04666Fc gamma R-mediated phagocytosis2.42E-025P23528, P06396, O14494, P14598, P17252CFL1, GSN, PLPP1, NCF1, PRKCAMore
Hyoscyaminehsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Hyoscyaminehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Hyoscyaminehsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Hyoscyaminehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Hyoscyaminehsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Hyoscyaminehsa04725Cholinergic synapse4.10E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Hyoscyaminehsa04727GABAergic synapse1.63E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Hyoscyaminehsa04744Phototransduction2.80E-022P62873, P0DP23GNB1, CALM1More
Hyoscyaminehsa04916Melanogenesis4.80E-024P0DP23, Q9UJU2, P17252, P04628CALM1, LEF1, PRKCA, WNT1More
Hyoscyaminehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Hyoscyaminehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Hyoscyaminehsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P49407PIK3CB, GNG5, GNG10, VEGFC, ARRB1More
Hyoscyaminehsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Hyoscyaminehsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Hyoscyaminehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Hyoscyaminehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Hyoscyaminehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Hyoscyaminehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Hyoscyaminehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Hyoscyaminehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Hyoscyaminehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Hyoscyaminehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Hyoscyaminehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Hyoscyaminehsa05132Salmonella infection2.53E-0312P51617, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371IRAK1, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Hyoscyaminehsa05133Pertussis4.20E-021P0C0L4C4AMore
Hyoscyaminehsa05140Leishmaniasis4.50E-035P14598, O60603, P25963, P29350, Q15080NCF1, TLR2, NFKBIA, PTPN6, NCF4More
Hyoscyaminehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Hyoscyaminehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Hyoscyaminehsa05152Tuberculosis5.68E-039Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Hyoscyaminehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Hyoscyaminehsa05169Epstein-Barr virus infection3.72E-026Q13547, P42338, P07948, Q13761, O75293, P07766HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3EMore
Hyoscyaminehsa05170Human immunodeficiency virus 1 infection5.94E-0312P62873, P0DP23, P17252, O00463, Q14643, P01568, P51617, O60603, P23528, P10415, Q93034, Q9Y6Q5GNB1, CALM1, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, CFL1, BCL2, CUL5, AP1M2More
Hyoscyaminehsa05202Transcriptional misregulation in cancer1.60E-0519Q12778, Q15532, Q13315, P14780, P27930, P14923, Q16548, P11215, Q13489, Q13077, O15550, P04637, P35226, P05164, P08246, Q9C0K0, Q13547, P12980, P24522FOXO1, SS18, ATM, MMP9, IL1R2, JUP, BCL2A1, ITGAM, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Hyoscyaminehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Hyoscyaminehsa05205Proteoglycans in cancer1.09E-0210Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63More
Hyoscyaminehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.84E-025P20963, P09693, O60603, P10747, Q04759CD247, CD3G, TLR2, CD28, PRKCQMore
Hyoscyaminehsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Hyoscyaminehsa05321Inflammatory bowel disease1.17E-035O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Hyoscyaminehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Hyoscyaminehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Hyoscyaminehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Hyoscyaminehsa05332Graft-versus-host disease3.29E-046P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Hyoscyaminehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Hyoscyaminehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Hyoscyamine (SDC: 5.94)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P21589NT5E5'NonenucleotidasePredicted10.29240.08550.15390.4711
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)