PharmaCoNets of Hydroxyzine (SPCN: 103.40 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Hydroxyzinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Hydroxyzinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Hydroxyzinehsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Hydroxyzinehsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Hydroxyzinehsa00630Glyoxylate and dicarboxylate metabolism9.21E-032P40925, P15104MDH1, GLULMore
Hydroxyzinehsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Hydroxyzinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Hydroxyzinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Hydroxyzinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Hydroxyzinehsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Hydroxyzinehsa01522Endocrine resistance4.47E-042P04049, P08069RAF1, IGF1RMore
Hydroxyzinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Hydroxyzinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Hydroxyzinehsa03040Spliceosome1.08E-027Q14562, O43143, O60508, Q07955, Q01130, Q13243, P11142DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5, HSPA8More
Hydroxyzinehsa04010MAPK signaling pathway1.69E-032P04049, P08069RAF1, IGF1RMore
Hydroxyzinehsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Hydroxyzinehsa04014Ras signaling pathway1.26E-039P04049, Q9NRA1, P08069, Q13009, P0DP23, P62873, P63218, P50151, P19174RAF1, PDGFC, IGF1R, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Hydroxyzinehsa04015Rap1 signaling pathway8.67E-042P04049, P08069RAF1, IGF1RMore
Hydroxyzinehsa04022cGMP-PKG signaling pathway3.15E-021P04049RAF1More
Hydroxyzinehsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Hydroxyzinehsa04060Cytokine-cytokine receptor interaction4.71E-022P78552, O75509IL13RA1, TNFRSF21More
Hydroxyzinehsa04062Chemokine signaling pathway5.80E-0410P07948, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P04049, P25963LYN, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, RAF1, NFKBIAMore
Hydroxyzinehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Hydroxyzinehsa04068FoxO signaling pathway3.80E-042P04049, P08069RAF1, IGF1RMore
Hydroxyzinehsa04070Phosphatidylinositol signaling system2.93E-024P19174, P0DP23, P23743, P27987PLCG1, CALM1, DGKA, ITPKBMore
Hydroxyzinehsa04071Sphingolipid signaling pathway3.35E-035P04049, P21453, Q9H228, P01375, Q13362RAF1, S1PR1, EDG8, TNF, PPP2R5CMore
Hydroxyzinehsa04072Phospholipase D signaling pathway7.52E-043P04049, Q92529, Q14344RAF1, SHC3, GNA13More
Hydroxyzinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Hydroxyzinehsa04114Oocyte meiosis2.99E-021P08069IGF1RMore
Hydroxyzinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Hydroxyzinehsa04140Autophagy - animal7.72E-042P08069, P04049IGF1R, RAF1More
Hydroxyzinehsa04141Protein processing in endoplasmic reticulum8.60E-036P30101, P60604, P11142, P08238, Q9H173, Q9UNL2PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3More
Hydroxyzinehsa04145Phagosome6.51E-036P11215, P14598, Q71U36, Q13509, P68371, Q13488ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1More
Hydroxyzinehsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Hydroxyzinehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Hydroxyzinehsa04210Apoptosis2.16E-021P04049RAF1More
Hydroxyzinehsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Hydroxyzinehsa04213Longevity regulating pathway - multiple species2.83E-033P08069, Q9Y4H2, Q13547IGF1R, IRS2, HDAC1More
Hydroxyzinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Hydroxyzinehsa04218Cellular senescence2.49E-021P04049RAF1More
Hydroxyzinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Hydroxyzinehsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Hydroxyzinehsa04360Axon guidance2.49E-021P04049RAF1More
Hydroxyzinehsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Hydroxyzinehsa04371Apelin signaling pathway3.46E-048P62873, P63218, P50151, P04049, Q13370, Q14344, P84022, P0DP23GNB1, GNG5, GNG10, RAF1, PDE3B, GNA13, SMAD3, CALM1More
Hydroxyzinehsa04510Focal adhesion1.18E-032P04049, P08069RAF1, IGF1RMore
Hydroxyzinehsa04520Adherens junction8.29E-031P08069IGF1RMore
Hydroxyzinehsa04540Gap junction2.22E-035Q13509, P68371, Q71U36, P04049, Q9NRA1TUBB3, TUBB2C, TUBA1A, RAF1, PDGFCMore
Hydroxyzinehsa04550Signaling pathways regulating pluripotency of stem cells3.80E-042P04049, P08069RAF1, IGF1RMore
Hydroxyzinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Hydroxyzinehsa04613Neutrophil extracellular trap formation2.71E-0511P04049, P11215, Q13547, P04908, Q93077, P58876, Q16778, O60814, P68431, O43315, Q16539RAF1, ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Hydroxyzinehsa04623Cytosolic DNA-sensing pathway2.59E-022P01568, P25963IFNA21, NFKBIAMore
Hydroxyzinehsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Hydroxyzinehsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Hydroxyzinehsa04650Natural killer cell mediated cytotoxicity2.93E-058P01375, P20963, P04049, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, RAF1, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Hydroxyzinehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Hydroxyzinehsa04659Th17 cell differentiation1.11E-026P25963, P19174, P42224, P14784, P84022, P08238NFKBIA, PLCG1, STAT1, IL2RB, SMAD3, HSP90AB1More
Hydroxyzinehsa04660T cell receptor signaling pathway1.66E-021P04049RAF1More
Hydroxyzinehsa04662B cell receptor signaling pathway9.95E-031P04049RAF1More
Hydroxyzinehsa04664Fc epsilon RI signaling pathway1.24E-035P04141, P07948, P19174, P04049, P09917CSF2, LYN, PLCG1, RAF1, ALOX5More
Hydroxyzinehsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Hydroxyzinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Hydroxyzinehsa04713Circadian entrainment2.18E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Hydroxyzinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Hydroxyzinehsa04720Long-term potentiation1.66E-021P04049RAF1More
Hydroxyzinehsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Hydroxyzinehsa04724Glutamatergic synapse1.57E-024P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Hydroxyzinehsa04726Serotonergic synapse5.74E-035P62873, P63218, P50151, P09917, P04049GNB1, GNG5, GNG10, ALOX5, RAF1More
Hydroxyzinehsa04727GABAergic synapse4.18E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Hydroxyzinehsa04730Long-term depression4.15E-044Q14344, P08069, P04049, P07948GNA13, IGF1R, RAF1, LYNMore
Hydroxyzinehsa04744Phototransduction9.21E-032P62873, P0DP23GNB1, CALM1More
Hydroxyzinehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Hydroxyzinehsa04910Insulin signaling pathway1.49E-021P04049RAF1More
Hydroxyzinehsa04912GnRH signaling pathway1.82E-021P04049RAF1More
Hydroxyzinehsa04913Ovarian steroidogenesis7.72E-033P42330, P22694, P08069AKR1C3, PRKACB, IGF1RMore
Hydroxyzinehsa04914Progesterone-mediated oocyte maturation4.47E-042P08069, P04049IGF1R, RAF1More
Hydroxyzinehsa04915Estrogen signaling pathway2.99E-021P04049RAF1More
Hydroxyzinehsa04916Melanogenesis1.33E-021P04049RAF1More
Hydroxyzinehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Hydroxyzinehsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Hydroxyzinehsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Hydroxyzinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Hydroxyzinehsa04926Relaxin signaling pathway6.24E-035P18848, P22694, P14780, P04049, P30679ATF4, PRKACB, MMP9, RAF1, GNA15More
Hydroxyzinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Hydroxyzinehsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Hydroxyzinehsa04929GnRH secretion4.98E-031P04049RAF1More
Hydroxyzinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Hydroxyzinehsa04935Growth hormone synthesis, secretion and action2.16E-021P04049RAF1More
Hydroxyzinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Hydroxyzinehsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Hydroxyzinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Hydroxyzinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Hydroxyzinehsa05012Parkinson disease1.77E-026P60604, P19174, P0DP23, Q71U36, Q13509, P68371UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2CMore
Hydroxyzinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Hydroxyzinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Hydroxyzinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Hydroxyzinehsa05032Morphine addiction2.18E-024P62873, P63218, P50151, Q13370GNB1, GNG5, GNG10, PDE3BMore
Hydroxyzinehsa05034Alcoholism1.49E-045Q13547, P04049, P58876, Q16778, O60814HDAC1, RAF1, H2BC5, HIST2H2BE, H2BC12More
Hydroxyzinehsa05120Epithelial cell signaling in Helicobacter pylori infection1.08E-024P25963, Q13488, P19174, P07948NFKBIA, TCIRG1, PLCG1, LYNMore
Hydroxyzinehsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Hydroxyzinehsa05132Salmonella infection1.82E-028P25963, P08238, P04049, O75369, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, RAF1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41More
Hydroxyzinehsa05134Legionellosis4.75E-023P25963, P11215, P11142NFKBIA, ITGAM, HSPA8More
Hydroxyzinehsa05140Leishmaniasis4.82E-024P14598, P11215, P42224, P25963NCF1, ITGAM, STAT1, NFKBIAMore
Hydroxyzinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Hydroxyzinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Hydroxyzinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Hydroxyzinehsa05152Tuberculosis3.98E-021P04049RAF1More
Hydroxyzinehsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Hydroxyzinehsa05161Hepatitis B1.99E-021P04049RAF1More
Hydroxyzinehsa05163Human cytomegalovirus infection3.15E-039P04049, P25963, P62873, P63218, P50151, P0DP23, Q14344, P30101, P01568RAF1, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, PDIA3, IFNA21More
Hydroxyzinehsa05164Influenza A3.65E-021P04049RAF1More
Hydroxyzinehsa05167Kaposi sarcoma-associated herpesvirus infection2.04E-0511P01568, P42224, P25963, P62873, P63218, P50151, P19174, P04049, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, RAF1, LYN, CSF2, CALM1More
Hydroxyzinehsa05168Herpes simplex virus 1 infection3.79E-029P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q13398, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF211, ZNF189More
Hydroxyzinehsa05170Human immunodeficiency virus 1 infection2.44E-039P04049, P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174RAF1, GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1More
Hydroxyzinehsa05200Pathways in cancer1.99E-0315P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Hydroxyzinehsa05202Transcriptional misregulation in cancer8.55E-045P27930, P11215, P08069, Q13547, P12980IL1R2, ITGAM, IGF1R, HDAC1, LYL1More
Hydroxyzinehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Hydroxyzinehsa05205Proteoglycans in cancer2.86E-037P04049, P14780, P01375, P08069, P23588, Q13635, P22694RAF1, MMP9, TNF, IGF1R, EIF4B, PTCH1, PRKACBMore
Hydroxyzinehsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Hydroxyzinehsa05210Colorectal cancer1.66E-021P04049RAF1More
Hydroxyzinehsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Hydroxyzinehsa05212Pancreatic cancer9.52E-034P04049, P42224, P84022, O75293RAF1, STAT1, SMAD3, GADD45BMore
Hydroxyzinehsa05213Endometrial cancer9.95E-031P04049RAF1More
Hydroxyzinehsa05214Glioma1.00E-035P08069, P0DP23, P04049, P19174, O75293IGF1R, CALM1, RAF1, PLCG1, GADD45BMore
Hydroxyzinehsa05215Prostate cancer1.65E-042P08069, P04049IGF1R, RAF1More
Hydroxyzinehsa05218Melanoma3.85E-052P08069, P04049IGF1R, RAF1More
Hydroxyzinehsa05219Bladder cancer4.98E-031P04049RAF1More
Hydroxyzinehsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Hydroxyzinehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Hydroxyzinehsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Hydroxyzinehsa05224Breast cancer2.11E-042P04049, P08069RAF1, IGF1RMore
Hydroxyzinehsa05225Hepatocellular carcinoma1.81E-054P04049, Q92529, P08069, P51531RAF1, SHC3, IGF1R, SMARCA2More
Hydroxyzinehsa05226Gastric cancer8.29E-031P04049RAF1More
Hydroxyzinehsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Hydroxyzinehsa05231Choline metabolism in cancer1.33E-021P04049RAF1More
Hydroxyzinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.66E-021P04049RAF1More
Hydroxyzinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Hydroxyzinehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Hydroxyzinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Hydroxyzinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Hydroxyzinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Hydroxyzine (SDC: 5.04)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)