PharmaCoNets of Hydroxychloroquine (SPCN: 21.41 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Hydroxychloroquinehsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Hydroxychloroquinehsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Hydroxychloroquinehsa00600Sphingolipid metabolism4.56E-023Q9BX95, Q06136, P06280SGPP1, FVT1, GLAMore
Hydroxychloroquinehsa00630Glyoxylate and dicarboxylate metabolism9.21E-032P40925, P15104MDH1, GLULMore
Hydroxychloroquinehsa00830Retinol metabolism3.15E-021P00325ADH1BMore
Hydroxychloroquinehsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Hydroxychloroquinehsa03013RNA transport1.91E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Hydroxychloroquinehsa03020RNA polymerase1.31E-022P24928, P62487POLR2A, POLR2GMore
Hydroxychloroquinehsa03040Spliceosome1.08E-027Q14562, O43143, O60508, Q07955, Q01130, Q13243, P11142DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5, HSPA8More
Hydroxychloroquinehsa04014Ras signaling pathway8.66E-037Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Hydroxychloroquinehsa04062Chemokine signaling pathway1.59E-039P07948, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963LYN, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIAMore
Hydroxychloroquinehsa04064NF-kappa B signaling pathway2.83E-028P10415, Q13489, O00463, Q13546, Q9UDY8, Q13077, Q16548, P24522BCL2, BIRC3, TRAF5, RIPK1, MALT1, TRAF1, BCL2A1, GADD45AMore
Hydroxychloroquinehsa04070Phosphatidylinositol signaling system2.93E-024P19174, P0DP23, P23743, P27987PLCG1, CALM1, DGKA, ITPKBMore
Hydroxychloroquinehsa04071Sphingolipid signaling pathway1.03E-026P21453, Q9H228, Q16537, Q9BX95, Q16539, P10415S1PR1, EDG8, PPP2R5E, SGPP1, MAPK14, BCL2More
Hydroxychloroquinehsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Hydroxychloroquinehsa04141Protein processing in endoplasmic reticulum8.60E-036P30101, P60604, P11142, P08238, Q9H173, Q9UNL2PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3More
Hydroxychloroquinehsa04145Phagosome6.51E-036P11215, P14598, Q71U36, Q13509, P68371, Q13488ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1More
Hydroxychloroquinehsa04371Apelin signaling pathway7.95E-047P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1More
Hydroxychloroquinehsa04392Hippo signaling pathway - multiple species6.35E-031Q9UGP4LIMD1More
Hydroxychloroquinehsa04540Gap junction1.08E-024Q13509, P68371, Q71U36, Q9NRA1TUBB3, TUBB2C, TUBA1A, PDGFCMore
Hydroxychloroquinehsa04612Antigen processing and presentation4.78E-026P48382, P26715, P26717, Q13241, O43908, P01375RFX5, KLRC1, KLRC2, KLRD1, KLRC4, TNFMore
Hydroxychloroquinehsa04613Neutrophil extracellular trap formation7.45E-0312O60603, P05164, P08246, Q9UM07, Q92769, Q6FI13, Q15080, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, HDAC2, H2AC18; H2AC19, NCF4, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Hydroxychloroquinehsa04621NOD-like receptor signaling pathway2.27E-029Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Hydroxychloroquinehsa04623Cytosolic DNA-sensing pathway2.59E-022P01568, P25963IFNA21, NFKBIAMore
Hydroxychloroquinehsa04640Hematopoietic cell lineage4.95E-023P01730, P06127, P09564CD4, CD5, CD7More
Hydroxychloroquinehsa04650Natural killer cell mediated cytotoxicity1.25E-028P01375, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Hydroxychloroquinehsa04659Th17 cell differentiation1.11E-026P25963, P19174, P42224, P14784, P84022, P08238NFKBIA, PLCG1, STAT1, IL2RB, SMAD3, HSP90AB1More
Hydroxychloroquinehsa04664Fc epsilon RI signaling pathway6.97E-034P04141, P07948, P19174, P09917CSF2, LYN, PLCG1, ALOX5More
Hydroxychloroquinehsa04668TNF signaling pathway4.96E-026O00463, Q13546, Q13489, Q16539, Q13077, P14780TRAF5, RIPK1, BIRC3, MAPK14, TRAF1, MMP9More
Hydroxychloroquinehsa04713Circadian entrainment2.18E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Hydroxychloroquinehsa04724Glutamatergic synapse1.57E-024P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Hydroxychloroquinehsa04726Serotonergic synapse3.80E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Hydroxychloroquinehsa04727GABAergic synapse4.18E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Hydroxychloroquinehsa04730Long-term depression4.86E-022Q14344, P07948GNA13, LYNMore
Hydroxychloroquinehsa04744Phototransduction9.21E-032P62873, P0DP23GNB1, CALM1More
Hydroxychloroquinehsa04912GnRH signaling pathway4.99E-021P18146EGR1More
Hydroxychloroquinehsa04972Pancreatic secretion1.31E-022Q08828, P62491ADCY1, RAB11AMore
Hydroxychloroquinehsa05012Parkinson disease1.77E-026P60604, P19174, P0DP23, Q71U36, Q13509, P68371UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2CMore
Hydroxychloroquinehsa05032Morphine addiction2.18E-024P62873, P63218, P50151, Q13370GNB1, GNG5, GNG10, PDE3BMore
Hydroxychloroquinehsa05120Epithelial cell signaling in Helicobacter pylori infection1.08E-024P25963, Q13488, P19174, P07948NFKBIA, TCIRG1, PLCG1, LYNMore
Hydroxychloroquinehsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Hydroxychloroquinehsa05132Salmonella infection2.75E-027P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41More
Hydroxychloroquinehsa05134Legionellosis4.75E-023P25963, P11215, P11142NFKBIA, ITGAM, HSPA8More
Hydroxychloroquinehsa05140Leishmaniasis4.82E-024P14598, P11215, P42224, P25963NCF1, ITGAM, STAT1, NFKBIAMore
Hydroxychloroquinehsa05144Malaria3.12E-024P60033, P01375, P35443, P26718CD81, TNF, THBS4, KLRK1More
Hydroxychloroquinehsa05150Staphylococcus aureus infection1.02E-037P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Hydroxychloroquinehsa05163Human cytomegalovirus infection2.56E-038P25963, P62873, P63218, P50151, P0DP23, Q14344, P30101, P01568NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, PDIA3, IFNA21More
Hydroxychloroquinehsa05167Kaposi sarcoma-associated herpesvirus infection8.62E-0510P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1More
Hydroxychloroquinehsa05168Herpes simplex virus 1 infection3.79E-029P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q13398, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF211, ZNF189More
Hydroxychloroquinehsa05170Human immunodeficiency virus 1 infection1.19E-028P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1More
Hydroxychloroquinehsa05200Pathways in cancer1.99E-0315P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Hydroxychloroquinehsa05202Transcriptional misregulation in cancer1.61E-0313Q15532, P41732, P14780, P27930, Q16548, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0, Q92769, P24522SS18, TSPAN7, MMP9, IL1R2, BCL2A1, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11B, HDAC2, GADD45AMore
Hydroxychloroquinehsa05212Pancreatic cancer4.75E-023P42224, P84022, O75293STAT1, SMAD3, GADD45BMore
Hydroxychloroquinehsa05214Glioma4.75E-023P0DP23, P19174, O75293CALM1, PLCG1, GADD45BMore
Hydroxychloroquinehsa05217Basal cell carcinoma2.01E-024Q13635, P04628, Q9UJU2, P24522PTCH1, WNT1, LEF1, GADD45AMore

Community members of Hydroxychloroquine (SDC: 2.70)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
P04156PRNPMajor prion proteinPredicted00.59090.173700.6429
P09958FURINFurinPredicted10.15690.07500.2286
P03950ANGAngiogeninPredicted10.2270.01670.1870.3339
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)