PharmaCoNets of Hydroxocobalamin (SPCN: 2.20 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Hydroxocobalaminhsa00190Oxidative phosphorylation3.27E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Hydroxocobalaminhsa00280Valine, leucine and isoleucine degradation2.75E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Hydroxocobalaminhsa01100Metabolic pathways1.66E-0231Q9Y234, O14521, P15144, Q99707, P11310, P27707, Q13370, P36959, Q13956, P22748, P55809, P06280, P30043, Q02252, O60701, O14772, O95954, Q9HCC0, P33121, P04406, Q96EB6, O15466, P36551, Q9BX95, P09960, Q9P2R7, Q9UHY7, P35573, Q13488, Q16718, Q02809LIPT1, SDHD, ANPEP, MTR, ACADM, DCK, PDE3B, GMPR, PDE6H, CA4, OXCT1, GLA, BLVRB, ALDH6A1, UGDH, FPGT, FTCD, MCCC2, ACSL1, GAPDH, SIRT1, ST8SIA5, CPOX, SGPP1, LTA4H, SUCLA2, ENOPH1, AGL, TCIRG1, NDUFA5, PLOD1More
Hydroxocobalaminhsa03013RNA transport3.46E-0311O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, Q14240, Q9Y6A5XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, EIF4A2, TACC3More
Hydroxocobalaminhsa03018RNA degradation2.97E-022Q9Y2L1, Q8IU60DIS3, DCP2More
Hydroxocobalaminhsa03450Non-homologous end-joining3.15E-021P13010XRCC5More
Hydroxocobalaminhsa04064NF-kappa B signaling pathway1.86E-029P10415, O00463, P01375, Q04759, Q13077, Q16548, P06239, P24522, P09341BCL2, TRAF5, TNF, PRKCQ, TRAF1, BCL2A1, LCK, GADD45A, CXCL1More
Hydroxocobalaminhsa04071Sphingolipid signaling pathway2.52E-037P17252, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415PRKCA, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Hydroxocobalaminhsa04114Oocyte meiosis3.60E-026O95067, Q9UJX2, Q14643, P22694, Q16539, Q13362CCNB2, CDC23, ITPR1, PRKACB, MAPK14, PPP2R5CMore
Hydroxocobalaminhsa04140Autophagy - animal3.50E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Hydroxocobalaminhsa04145Phagosome4.84E-0511O75015, Q15075, Q15080, P14598, Q13509, Q13488, P05164, P78380, O60603, P35443, P13765FCGR3B, EEA1, NCF4, NCF1, TUBB3, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Hydroxocobalaminhsa04217Necroptosis1.32E-025P01568, P07384, Q6FI13, P10415, O43633IFNA21, CAPN1, H2AC18; H2AC19, BCL2, CHMP2AMore
Hydroxocobalaminhsa04540Gap junction1.78E-023P17252, Q13509, Q14643PRKCA, TUBB3, ITPR1More
Hydroxocobalaminhsa04612Antigen processing and presentation7.10E-038P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Hydroxocobalaminhsa04613Neutrophil extracellular trap formation1.85E-0212O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Hydroxocobalaminhsa04621NOD-like receptor signaling pathway1.75E-0210Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, DEFA4More
Hydroxocobalaminhsa04630JAK-STAT signaling pathway4.27E-024P10415, P40189, Q9UHF4, P01568BCL2, IL6ST, IL20RA, IFNA21More
Hydroxocobalaminhsa04640Hematopoietic cell lineage3.29E-028P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Hydroxocobalaminhsa04650Natural killer cell mediated cytotoxicity7.61E-039P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Hydroxocobalaminhsa04657IL-17 signaling pathway4.82E-026O00463, Q16539, P09341, P14780, P80188, P01375TRAF5, MAPK14, CXCL1, MMP9, LCN2, TNFMore
Hydroxocobalaminhsa04658Th1 and Th2 cell differentiation5.60E-049Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOBMore
Hydroxocobalaminhsa04659Th17 cell differentiation1.42E-028Q04759, Q16539, P06239, P13765, Q9UL17, P23771, P09693, P20963PRKCQ, MAPK14, LCK, HLA-DOB, TBX21, GATA3, CD3G, CD247More
Hydroxocobalaminhsa04660T cell receptor signaling pathway2.83E-0310P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14More
Hydroxocobalaminhsa04666Fc gamma R-mediated phagocytosis2.35E-023P23528, P14598, P17252CFL1, NCF1, PRKCAMore
Hydroxocobalaminhsa04668TNF signaling pathway2.63E-027P01375, O00463, Q16539, P09341, P20749, Q13077, P14780TNF, TRAF5, MAPK14, CXCL1, BCL3, TRAF1, MMP9More
Hydroxocobalaminhsa04725Cholinergic synapse2.35E-023Q14643, P17252, P10415ITPR1, PRKCA, BCL2More
Hydroxocobalaminhsa04726Serotonergic synapse4.57E-023Q14643, P17252, P33260ITPR1, PRKCA, CYP2C18More
Hydroxocobalaminhsa04730Long-term depression1.94E-022P17252, Q14643PRKCA, ITPR1More
Hydroxocobalaminhsa04918Thyroid hormone synthesis4.49E-022P17252, Q14643PRKCA, ITPR1More
Hydroxocobalaminhsa04922Glucagon signaling pathway3.74E-023Q12778, Q13370, Q14643FOXO1, PDE3B, ITPR1More
Hydroxocobalaminhsa04924Renin secretion3.11E-022Q14643, Q13370ITPR1, PDE3BMore
Hydroxocobalaminhsa04928Parathyroid hormone synthesis, secretion and action5.37E-034Q14643, P17252, P10415, Q9UEF7ITPR1, PRKCA, BCL2, KLMore
Hydroxocobalaminhsa04929GnRH secretion3.11E-022Q14643, P17252ITPR1, PRKCAMore
Hydroxocobalaminhsa04961Endocrine and other factor-regulated calcium reabsorption3.11E-022Q9UEF7, P17252KL, PRKCAMore
Hydroxocobalaminhsa04972Pancreatic secretion3.11E-022Q14643, P17252ITPR1, PRKCAMore
Hydroxocobalaminhsa05022Pathways of neurodegeneration - multiple diseases2.66E-026Q14643, Q13509, P10415, P17252, P07384, P04628ITPR1, TUBB3, BCL2, PRKCA, CAPN1, WNT1More
Hydroxocobalaminhsa05110Vibrio cholerae infection4.49E-022Q13488, P17252TCIRG1, PRKCAMore
Hydroxocobalaminhsa05140Leishmaniasis6.04E-037P13612, O75015, P13765, O60603, P01375, Q16539, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14, NCF4More
Hydroxocobalaminhsa05144Malaria4.68E-024O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Hydroxocobalaminhsa05146Amoebiasis1.36E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Hydroxocobalaminhsa05150Staphylococcus aureus infection4.94E-025P21730, P21462, O75015, P13765, P12838C5AR1, FPR1, FCGR3B, HLA-DOB, DEFA4More
Hydroxocobalaminhsa05152Tuberculosis7.48E-035Q13488, O60603, P10415, P01568, Q9UDY8TCIRG1, TLR2, BCL2, IFNA21, MALT1More
Hydroxocobalaminhsa05170Human immunodeficiency virus 1 infection9.30E-0414P01375, P17252, O00463, Q14643, P01568, Q16539, O60603, O95067, P23528, P09693, P20963, P10415, Q93034, Q9Y6Q5TNF, PRKCA, TRAF5, ITPR1, IFNA21, MAPK14, TLR2, CCNB2, CFL1, CD3G, CD247, BCL2, CUL5, AP1M2More
Hydroxocobalaminhsa05202Transcriptional misregulation in cancer1.36E-0212P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P24522MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, GADD45AMore
Hydroxocobalaminhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.36E-027O95267, P20963, P09693, P06239, O60603, Q04759, Q16539RASGRP1, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14More
Hydroxocobalaminhsa05310Asthma1.59E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Hydroxocobalaminhsa05320Autoimmune thyroid disease4.49E-022P01568, P10747IFNA21, CD28More
Hydroxocobalaminhsa05321Inflammatory bowel disease1.04E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Hydroxocobalaminhsa05323Rheumatoid arthritis1.78E-023Q13488, P10747, O60603TCIRG1, CD28, TLR2More
Hydroxocobalaminhsa05332Graft-versus-host disease1.71E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Hydroxocobalaminhsa05418Fluid shear stress and atherosclerosis3.49E-027Q16539, Q14145, P10599, P14780, P01375, P10415, P27930MAPK14, KEAP1, TXN, MMP9, TNF, BCL2, IL1R2More

Community members of Hydroxocobalamin (SDC: 0.30)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q99707MTRMethionine synthaseReported00.16120.05620.1950.3881
P20061TCN1TranscobalaminNone1Reported10.24870.006700.1377
Q9BXJ7AMNProtein amnionlessReported00.00910.006700.0179
Q7Z3S9NOTCH2NLNotch homolog 2 NNoneterminalNonelike protein APredicted00.2120.008700.1234
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)