PharmaCoNets of Hydrocortisone-probutate (SPCN: 106.53 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Hydrocortisone-probutatehsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Hydrocortisone-probutatehsa00071Fatty acid degradation3.77E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Hydrocortisone-probutatehsa00190Oxidative phosphorylation8.71E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Hydrocortisone-probutatehsa00220Arginine biosynthesis1.94E-033P15104, P05089, P49448GLUL, ARG1, GLUD2More
Hydrocortisone-probutatehsa00250Alanine, aspartate and glutamate metabolism4.32E-022P49448, P15104GLUD2, GLULMore
Hydrocortisone-probutatehsa00480Glutathione metabolism2.60E-055Q9UJ14, P11413, Q16772, P09211, P30041GGTL3, G6PD, GSTA3, GSTP1, PRDX6More
Hydrocortisone-probutatehsa00500Starch and sucrose metabolism5.41E-053O43451, P46976, P06737MGAM, GYG1, PYGLMore
Hydrocortisone-probutatehsa00730Thiamine metabolism4.32E-022P05186, P24666ALPL, ACP1More
Hydrocortisone-probutatehsa00910Nitrogen metabolism4.32E-022P15104, P49448GLUL, GLUD2More
Hydrocortisone-probutatehsa00970Aminoacyl-tRNA biosynthesis1.92E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Hydrocortisone-probutatehsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Hydrocortisone-probutatehsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Hydrocortisone-probutatehsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Hydrocortisone-probutatehsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Hydrocortisone-probutatehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Hydrocortisone-probutatehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Hydrocortisone-probutatehsa01522Endocrine resistance2.16E-021P04049RAF1More
Hydrocortisone-probutatehsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Hydrocortisone-probutatehsa03013RNA transport9.39E-059Q15287, Q9UBU9, P35658, P63279, P68104, P55884, O15371, P20042, Q14232RNPS1, NXF1, NUP214, UBE2I, EEF1A1, EIF3B, EIF3D, EIF2S2, EIF2B1More
Hydrocortisone-probutatehsa03040Spliceosome3.98E-024Q15427, P38159, P61978, P11142SF3B4, RBMX, HNRPK, HSPA8More
Hydrocortisone-probutatehsa03060Protein export9.07E-042P37108, Q15005SRP14, SPCS2More
Hydrocortisone-probutatehsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Hydrocortisone-probutatehsa04012ErbB signaling pathway8.14E-034P21860, Q13557, O14944, P04049ERBB3, CAMK2D, EREG, RAF1More
Hydrocortisone-probutatehsa04014Ras signaling pathway3.65E-021P04049RAF1More
Hydrocortisone-probutatehsa04015Rap1 signaling pathway2.99E-021P04049RAF1More
Hydrocortisone-probutatehsa04020Calcium signaling pathway2.19E-0510Q96DU7, Q08828, P45880, Q13557, P21860, P61073, P0DP24, P05141, P51828, P23634ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, CXCR4, CALM2, SLC25A5, ADCY7, ATP2B4More
Hydrocortisone-probutatehsa04022cGMP-PKG signaling pathway9.49E-049P04049, Q99941, P18848, P23634, Q08828, P51828, P05141, P45880, P0DP24RAF1, CREBL1, ATF4, ATP2B4, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2More
Hydrocortisone-probutatehsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Hydrocortisone-probutatehsa04061Viral protein interaction with cytokine and cytokine receptor9.15E-049Q8NHW4, P09341, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P01375CCL4L2, CXCL1, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, TNFMore
Hydrocortisone-probutatehsa04062Chemokine signaling pathway1.41E-029P25024, P25025, P07948, P42338, P63218, P50151, P49407, P04049, P49841CXCR1, CXCR2, LYN, PIK3CB, GNG5, GNG10, ARRB1, RAF1, GSK3BMore
Hydrocortisone-probutatehsa04064NF-kappa B signaling pathway1.25E-0412P10415, Q13489, Q13546, P01584, P29965, Q9UDY8, Q8WV28, Q13315, P63279, Q8NHW4, Q9UNE0, Q9NQC7BCL2, BIRC3, RIPK1, IL1B, CD40LG, MALT1, BLNK, ATM, UBE2I, CCL4L2, EDAR, CYLDMore
Hydrocortisone-probutatehsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Hydrocortisone-probutatehsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Hydrocortisone-probutatehsa04071Sphingolipid signaling pathway1.74E-025P04049, P17252, Q13362, Q9BX95, P10415RAF1, PRKCA, PPP2R5C, SGPP1, BCL2More
Hydrocortisone-probutatehsa04072Phospholipase D signaling pathway2.82E-021P04049RAF1More
Hydrocortisone-probutatehsa04080Neuroactive ligand-receptor interaction3.70E-027P08311, P48058, Q15722, Q9H228, P43657, P21730, P35318CTSG, GRIA4, LTB4R, EDG8, P2RY5, C5AR1, ADMMore
Hydrocortisone-probutatehsa04114Oocyte meiosis4.36E-025Q13557, P0DP24, Q08828, P51828, P27348CAMK2D, CALM2, ADCY1, ADCY7, YWHAQMore
Hydrocortisone-probutatehsa04140Autophagy - animal5.15E-026P04049, Q9NQL2, P22694, Q14643, Q9H1Y0, Q04759RAF1, RRAGD, PRKACB, ITPR1, ATG5, PRKCQMore
Hydrocortisone-probutatehsa04141Protein processing in endoplasmic reticulum5.75E-037Q99941, O75460, P17861, P11142, Q9H3Z4, P07900, Q9NR31CREBL1, ERN1, XBP1, HSPA8, DNAJC5, HSP90AA1, SAR1AMore
Hydrocortisone-probutatehsa04145Phagosome1.59E-037Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOBMore
Hydrocortisone-probutatehsa04150mTOR signaling pathway2.47E-025P42338, P04049, Q9NQL2, Q13322, P49841PIK3CB, RAF1, RRAGD, GRB10, GSK3BMore
Hydrocortisone-probutatehsa04151PI3K-Akt signaling pathway4.50E-029P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCAMore
Hydrocortisone-probutatehsa04210Apoptosis2.16E-021P04049RAF1More
Hydrocortisone-probutatehsa04211Longevity regulating pathway3.41E-037Q12778, Q08828, P51828, Q99941, P18848, Q9UEF7, Q96KQ7FOXO1, ADCY1, ADCY7, CREBL1, ATF4, KL, EHMT2More
Hydrocortisone-probutatehsa04217Necroptosis2.08E-0515P01568, P23458, Q13489, Q9NQC7, Q13546, P42224, P05141, P01584, P0C0S5, Q6FI13, P10415, Q13557, Q9H444, O43633, Q08752IFNA21, JAK1, BIRC3, CYLD, RIPK1, STAT1, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, BCL2, CAMK2D, CHMP4B, CHMP2A, PPIDMore
Hydrocortisone-probutatehsa04218Cellular senescence2.49E-021P04049RAF1More
Hydrocortisone-probutatehsa04261Adrenergic signaling in cardiomyocytes1.49E-0412P09493, Q08828, P51828, Q99941, P18848, Q13362, P0DP23, P0DP24, Q13557, P17252, P10415, P23634TPM1, ADCY1, ADCY7, CREBL1, ATF4, PPP2R5C, CALM1, CALM2, CAMK2D, PRKCA, BCL2, ATP2B4More
Hydrocortisone-probutatehsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Hydrocortisone-probutatehsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Hydrocortisone-probutatehsa04360Axon guidance2.49E-021P04049RAF1More
Hydrocortisone-probutatehsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Hydrocortisone-probutatehsa04371Apelin signaling pathway2.65E-021P04049RAF1More
Hydrocortisone-probutatehsa04380Osteoclast differentiation6.08E-0310Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P42338, P01584, P14778, O75015, Q8N149CYLD, GAB2, MAPK14, JAK1, LCK, PIK3CB, IL1B, IL1R1, FCGR3B, LILRA2More
Hydrocortisone-probutatehsa04510Focal adhesion3.48E-021P04049RAF1More
Hydrocortisone-probutatehsa04540Gap junction2.79E-035P17252, Q13509, P68371, P04049, Q14643PRKCA, TUBB3, TUBB2C, RAF1, ITPR1More
Hydrocortisone-probutatehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Hydrocortisone-probutatehsa04612Antigen processing and presentation3.60E-038P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Hydrocortisone-probutatehsa04613Neutrophil extracellular trap formation1.74E-0419P17252, P04049, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q16778, P68431, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539PRKCA, RAF1, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST2H2BE, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Hydrocortisone-probutatehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Hydrocortisone-probutatehsa04621NOD-like receptor signaling pathway3.13E-0417Q16539, Q14643, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, Q13546, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838MAPK14, ITPR1, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Hydrocortisone-probutatehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Hydrocortisone-probutatehsa04623Cytosolic DNA-sensing pathway5.86E-054P01584, P01568, Q13546, Q8NHW4IL1B, IFNA21, RIPK1, CCL4L2More
Hydrocortisone-probutatehsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Hydrocortisone-probutatehsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Hydrocortisone-probutatehsa04640Hematopoietic cell lineage3.92E-0411P13612, P14778, P27930, P15144, P25063, P07766, P09693, P01732, P01730, P13765, P01375ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, HLA-DOB, TNFMore
Hydrocortisone-probutatehsa04650Natural killer cell mediated cytotoxicity2.28E-0711P01375, P78314, P06239, O60880, P20963, P04049, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, RAF1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Hydrocortisone-probutatehsa04657IL-17 signaling pathway1.42E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Hydrocortisone-probutatehsa04658Th1 and Th2 cell differentiation2.79E-0912Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3More
Hydrocortisone-probutatehsa04659Th17 cell differentiation1.17E-0711Q04759, Q16539, P01730, P06239, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, CD4, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Hydrocortisone-probutatehsa04660T cell receptor signaling pathway7.66E-0915P01375, Q04759, P42338, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, PRKCQ, PIK3CB, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Hydrocortisone-probutatehsa04662B cell receptor signaling pathway1.99E-047P49841, P42338, P60033, P07948, P21854, Q8N149, P04049GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2, RAF1More
Hydrocortisone-probutatehsa04664Fc epsilon RI signaling pathway4.03E-035Q16539, P42338, P07948, P04049, P09917MAPK14, PIK3CB, LYN, RAF1, ALOX5More
Hydrocortisone-probutatehsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Hydrocortisone-probutatehsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Hydrocortisone-probutatehsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Hydrocortisone-probutatehsa04713Circadian entrainment1.25E-038P0DP23, P0DP24, Q13557, P17252, P62873, Q14643, Q08828, P51828CALM1, CALM2, CAMK2D, PRKCA, GNB1, ITPR1, ADCY1, ADCY7More
Hydrocortisone-probutatehsa04720Long-term potentiation7.87E-048P17252, Q13557, P0DP23, P0DP24, P18848, Q08828, P04049, Q14643PRKCA, CAMK2D, CALM1, CALM2, ATF4, ADCY1, RAF1, ITPR1More
Hydrocortisone-probutatehsa04722Neurotrophin signaling pathway4.44E-043Q05655, P04049, P52566PRKCD, RAF1, ARHGDIBMore
Hydrocortisone-probutatehsa04723Retrograde endocannabinoid signaling1.88E-038Q14643, P17252, P62873, P63218, P50151, P48058, Q16539, Q16718ITPR1, PRKCA, GNB1, GNG5, GNG10, GRIA4, MAPK14, NDUFA5More
Hydrocortisone-probutatehsa04724Glutamatergic synapse7.09E-035P48058, P43003, P63218, P50151, P15104GRIA4, SLC1A3, GNG5, GNG10, GLULMore
Hydrocortisone-probutatehsa04725Cholinergic synapse1.75E-038Q08828, P51828, Q14643, P17252, P62873, P18848, Q13557, P10415ADCY1, ADCY7, ITPR1, PRKCA, GNB1, ATF4, CAMK2D, BCL2More
Hydrocortisone-probutatehsa04726Serotonergic synapse1.33E-021P04049RAF1More
Hydrocortisone-probutatehsa04728Dopaminergic synapse1.89E-0416Q14643, P17252, P62873, P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, P0DP23, P0DP24, O15516, P48058ITPR1, PRKCA, GNB1, GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, CALM1, CALM2, CLOCK, GRIA4More
Hydrocortisone-probutatehsa04730Long-term depression1.16E-021P04049RAF1More
Hydrocortisone-probutatehsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Hydrocortisone-probutatehsa04750Inflammatory mediator regulation of TRP channels7.58E-0510P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, Q14643, Q04759, P0DP24IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, ITPR1, PRKCQ, CALM2More
Hydrocortisone-probutatehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Hydrocortisone-probutatehsa04910Insulin signaling pathway1.49E-021P04049RAF1More
Hydrocortisone-probutatehsa04911Insulin secretion2.95E-055Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Hydrocortisone-probutatehsa04912GnRH signaling pathway3.21E-049P17252, Q08828, P51828, P18848, Q13557, Q14643, P0DP23, P0DP24, P04049PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, ITPR1, CALM1, CALM2, RAF1More
Hydrocortisone-probutatehsa04914Progesterone-mediated oocyte maturation2.16E-021P04049RAF1More
Hydrocortisone-probutatehsa04915Estrogen signaling pathway1.26E-025P04049, Q99941, P51828, P07900, P11142RAF1, CREBL1, ADCY7, HSP90AA1, HSPA8More
Hydrocortisone-probutatehsa04916Melanogenesis1.80E-035Q13557, P0DP24, Q08828, P51828, P04049CAMK2D, CALM2, ADCY1, ADCY7, RAF1More
Hydrocortisone-probutatehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Hydrocortisone-probutatehsa04918Thyroid hormone synthesis4.47E-035Q08828, P51828, Q99941, P18848, P02768ADCY1, ADCY7, CREBL1, ATF4, ALBMore
Hydrocortisone-probutatehsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Hydrocortisone-probutatehsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Hydrocortisone-probutatehsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Hydrocortisone-probutatehsa04924Renin secretion8.71E-033Q14643, Q13370, P0DP23ITPR1, PDE3B, CALM1More
Hydrocortisone-probutatehsa04925Aldosterone synthesis and secretion8.00E-067Q99941, P18848, Q08828, P51828, P0DP24, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4More
Hydrocortisone-probutatehsa04926Relaxin signaling pathway2.32E-021P04049RAF1More
Hydrocortisone-probutatehsa04927Cortisol synthesis and secretion4.16E-034Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Hydrocortisone-probutatehsa04928Parathyroid hormone synthesis, secretion and action1.20E-025Q08828, P51828, P04049, Q99941, P18848ADCY1, ADCY7, RAF1, CREBL1, ATF4More
Hydrocortisone-probutatehsa04929GnRH secretion4.98E-031P04049RAF1More
Hydrocortisone-probutatehsa04930Type II diabetes mellitus2.68E-021Q05655PRKCDMore
Hydrocortisone-probutatehsa04932Non-alcoholic fatty liver disease3.45E-025P18848, O75460, P01584, P12074, O15239ATF4, ERN1, IL1B, COX6A1, NDUFA1More
Hydrocortisone-probutatehsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Hydrocortisone-probutatehsa04934Cushing syndrome2.69E-066Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Hydrocortisone-probutatehsa04935Growth hormone synthesis, secretion and action1.68E-025Q08828, P51828, P04049, Q99941, P18848ADCY1, ADCY7, RAF1, CREBL1, ATF4More
Hydrocortisone-probutatehsa04966Collecting duct acid secretion2.86E-022Q13488, Q9Y666TCIRG1, SLC12A7More
Hydrocortisone-probutatehsa04970Salivary secretion3.54E-023Q08828, P51828, P0DP24ADCY1, ADCY7, CALM2More
Hydrocortisone-probutatehsa04971Gastric acid secretion2.95E-055Q08828, P51828, P15311, P0DP24, Q13557ADCY1, ADCY7, VIL2, CALM2, CAMK2DMore
Hydrocortisone-probutatehsa04973Carbohydrate digestion and absorption1.57E-022O43451, P42338MGAM, PIK3CBMore
Hydrocortisone-probutatehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Hydrocortisone-probutatehsa05010Alzheimer disease7.87E-0624Q92542, O15239, Q16718, O14521, P05496, Q06055, P12074, Q14643, Q00535, O75460, P0DP23, P0DP24, P01584, P18848, Q13509, P68371, O15169, P05141, P45880, Q08752, P17861, P28070, P43686, P62195NCSTN, NDUFA1, NDUFA5, SDHD, ATP5G1, ATP5G2, COX6A1, ITPR1, CDK5, ERN1, CALM1, CALM2, IL1B, ATF4, TUBB3, TUBB2C, AXIN1, SLC25A5, VDAC2, PPID, XBP1, PSMB4, PSMC4, PSMC5More
Hydrocortisone-probutatehsa05012Parkinson disease9.44E-0518O15239, Q16718, O14521, P12074, Q06055, P05141, O75460, P18848, P17861, P28070, P43686, P62195, Q14643, P0DP23, P0DP24, Q13557, Q13509, P68371NDUFA1, NDUFA5, SDHD, COX6A1, ATP5G2, SLC25A5, ERN1, ATF4, XBP1, PSMB4, PSMC4, PSMC5, ITPR1, CALM1, CALM2, CAMK2D, TUBB3, TUBB2CMore
Hydrocortisone-probutatehsa05014Amyotrophic lateral sclerosis1.01E-023Q06055, P17861, P62195ATP5G2, XBP1, PSMC5More
Hydrocortisone-probutatehsa05016Huntington disease3.54E-028O15239, P12074, P24928, P62487, P05141, O75460, P28070, P43686NDUFA1, COX6A1, POLR2A, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4More
Hydrocortisone-probutatehsa05017Spinocerebellar ataxia1.42E-022P17861, P62195XBP1, PSMC5More
Hydrocortisone-probutatehsa05020Prion disease9.80E-0519P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P12074, Q14643, P18848, P05141, P45880, P28070, P43686, Q13509, P68371, Q99941, P14598, Q15080IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX6A1, ITPR1, ATF4, SLC25A5, VDAC2, PSMB4, PSMC4, TUBB3, TUBB2C, CREBL1, NCF1, NCF4More
Hydrocortisone-probutatehsa05022Pathways of neurodegeneration - multiple diseases8.91E-0626Q14643, Q13509, P68371, P10415, O15239, Q16718, O14521, P12074, Q06055, Q8TEV9, O75460, P18848, P17861, Q13561, P05141, P17252, Q00535, O15169, P01584, Q08752, P0DP23, P0DP24, Q13557, P28070, P43686, P62195ITPR1, TUBB3, TUBB2C, BCL2, NDUFA1, NDUFA5, SDHD, COX6A1, ATP5G2, SMCR8, ERN1, ATF4, XBP1, DCTN2, SLC25A5, PRKCA, CDK5, AXIN1, IL1B, PPID, CALM1, CALM2, CAMK2D, PSMB4, PSMC4, PSMC5More
Hydrocortisone-probutatehsa05030Cocaine addiction3.54E-023Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Hydrocortisone-probutatehsa05031Amphetamine addiction7.61E-034P0DP24, Q13557, Q99941, P18848CALM2, CAMK2D, CREBL1, ATF4More
Hydrocortisone-probutatehsa05034Alcoholism2.49E-021P04049RAF1More
Hydrocortisone-probutatehsa05120Epithelial cell signaling in Helicobacter pylori infection2.47E-035Q16539, P09341, P25024, P25025, P07948MAPK14, CXCL1, CXCR1, CXCR2, LYNMore
Hydrocortisone-probutatehsa05131Shigellosis3.99E-0310P68431, Q05655, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752, P07737H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID, PFN1More
Hydrocortisone-probutatehsa05132Salmonella infection1.08E-0413P04049, Q9UJU2, P84095, Q13546, Q13489, P10415, P07737, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371RAF1, LEF1, RHOG, RIPK1, BIRC3, BCL2, PFN1, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Hydrocortisone-probutatehsa05134Legionellosis5.53E-032Q9NR31, P68104SAR1A, EEF1A1More
Hydrocortisone-probutatehsa05135Yersinia infection5.36E-058P13612, P06239, Q16539, P01375, P42338, P49841, P01730, P01732ITGA4, LCK, MAPK14, TNF, PIK3CB, GSK3B, CD4, CD8AMore
Hydrocortisone-probutatehsa05140Leishmaniasis2.45E-0410P13612, O75015, P14598, P42224, P13765, O60603, P01375, P29350, Q16539, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, TNF, PTPN6, MAPK14, NCF4More
Hydrocortisone-probutatehsa05144Malaria6.84E-045P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Hydrocortisone-probutatehsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Hydrocortisone-probutatehsa05146Amoebiasis4.74E-059P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSGMore
Hydrocortisone-probutatehsa05150Staphylococcus aureus infection1.02E-037P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Hydrocortisone-probutatehsa05152Tuberculosis9.31E-049P04049, Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8RAF1, TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1More
Hydrocortisone-probutatehsa05160Hepatitis C1.99E-021P04049RAF1More
Hydrocortisone-probutatehsa05161Hepatitis B1.99E-021P04049RAF1More
Hydrocortisone-probutatehsa05163Human cytomegalovirus infection2.07E-0622P42338, P04049, P01375, P63218, P50151, Q14643, P0DP24, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, Q99941, P18848, O00463PIK3CB, RAF1, TNF, GNG5, GNG10, ITPR1, CALM2, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TRAF5More
Hydrocortisone-probutatehsa05164Influenza A3.65E-021P04049RAF1More
Hydrocortisone-probutatehsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Hydrocortisone-probutatehsa05167Kaposi sarcoma-associated herpesvirus infection1.48E-027P01568, P42224, P62873, Q14643, P04049, P0DP23, Q9UJU2IFNA21, STAT1, GNB1, ITPR1, RAF1, CALM1, LEF1More
Hydrocortisone-probutatehsa05169Epstein-Barr virus infection2.32E-029Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, P07766, P20963HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, CD3E, CD247More
Hydrocortisone-probutatehsa05170Human immunodeficiency virus 1 infection8.78E-0410P04049, P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5RAF1, GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2More
Hydrocortisone-probutatehsa05200Pathways in cancer4.99E-0212P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21More
Hydrocortisone-probutatehsa05202Transcriptional misregulation in cancer3.51E-0212P14780, P27930, Q15744, Q16548, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45AMore
Hydrocortisone-probutatehsa05203Viral carcinogenesis4.62E-023Q12933, P42229, Q15283TRAF2, STAT5A, RASA2More
Hydrocortisone-probutatehsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Hydrocortisone-probutatehsa05205Proteoglycans in cancer3.48E-021P04049RAF1More
Hydrocortisone-probutatehsa05206MicroRNAs in cancer6.19E-047P15311, P21860, P61978, P46531, P63279, P22105, P04049VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RAF1More
Hydrocortisone-probutatehsa05210Colorectal cancer1.66E-021P04049RAF1More
Hydrocortisone-probutatehsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Hydrocortisone-probutatehsa05212Pancreatic cancer1.16E-021P04049RAF1More
Hydrocortisone-probutatehsa05213Endometrial cancer9.95E-031P04049RAF1More
Hydrocortisone-probutatehsa05214Glioma9.95E-031P04049RAF1More
Hydrocortisone-probutatehsa05215Prostate cancer1.33E-021P04049RAF1More
Hydrocortisone-probutatehsa05218Melanoma6.63E-031P04049RAF1More
Hydrocortisone-probutatehsa05219Bladder cancer4.98E-031P04049RAF1More
Hydrocortisone-probutatehsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Hydrocortisone-probutatehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Hydrocortisone-probutatehsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Hydrocortisone-probutatehsa05224Breast cancer1.49E-021P04049RAF1More
Hydrocortisone-probutatehsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Hydrocortisone-probutatehsa05226Gastric cancer8.29E-031P04049RAF1More
Hydrocortisone-probutatehsa05230Central carbon metabolism in cancer1.00E-042P04049, P11413RAF1, G6PDMore
Hydrocortisone-probutatehsa05231Choline metabolism in cancer1.33E-021P04049RAF1More
Hydrocortisone-probutatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.65E-0611P42338, O95267, P07766, P20963, P09693, P06239, P04049, O60603, Q04759, Q16539, P01730PIK3CB, RASGRP1, CD3E, CD247, CD3G, LCK, RAF1, TLR2, PRKCQ, MAPK14, CD4More
Hydrocortisone-probutatehsa05310Asthma1.62E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Hydrocortisone-probutatehsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Hydrocortisone-probutatehsa05321Inflammatory bowel disease1.09E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Hydrocortisone-probutatehsa05322Systemic lupus erythematosus4.18E-037P08246, P09871, P10747, P13765, P29965, Q6FI13, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Hydrocortisone-probutatehsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Hydrocortisone-probutatehsa05330Allograft rejection1.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Hydrocortisone-probutatehsa05332Graft-versus-host disease1.76E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Hydrocortisone-probutatehsa05340Primary immunodeficiency3.76E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Hydrocortisone-probutatehsa05415Diabetic cardiomyopathy2.33E-026P17252, P14598, Q15080, Q16718, O14521, P11413PRKCA, NCF1, NCF4, NDUFA5, SDHD, G6PDMore
Hydrocortisone-probutatehsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More

Community members of Hydrocortisone-probutate (SDC: 4.35)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)