PharmaCoNets of Hydrocortisone-cypionate (SPCN: 85.97 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Hydrocortisone-cypionatehsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Hydrocortisone-cypionatehsa00190Oxidative phosphorylation4.09E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Hydrocortisone-cypionatehsa00220Arginine biosynthesis3.71E-063P15104, P05089, P49448GLUL, ARG1, GLUD2More
Hydrocortisone-cypionatehsa00250Alanine, aspartate and glutamate metabolism2.97E-032P49448, P15104GLUD2, GLULMore
Hydrocortisone-cypionatehsa00280Valine, leucine and isoleucine degradation1.67E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Hydrocortisone-cypionatehsa00480Glutathione metabolism2.60E-055Q9UJ14, P11413, Q16772, P09211, P30041GGTL3, G6PD, GSTA3, GSTP1, PRDX6More
Hydrocortisone-cypionatehsa00500Starch and sucrose metabolism1.18E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Hydrocortisone-cypionatehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Hydrocortisone-cypionatehsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Hydrocortisone-cypionatehsa00561Glycerolipid metabolism2.21E-023O14494, P06280, P23743PLPP1, GLA, DGKAMore
Hydrocortisone-cypionatehsa00562Inositol phosphate metabolism3.69E-023P27987, P19174, P42338ITPKB, PLCG1, PIK3CBMore
Hydrocortisone-cypionatehsa00600Sphingolipid metabolism3.96E-023Q9BX95, O14494, P06280SGPP1, PLPP1, GLAMore
Hydrocortisone-cypionatehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Hydrocortisone-cypionatehsa00730Thiamine metabolism4.32E-022P05186, P24666ALPL, ACP1More
Hydrocortisone-cypionatehsa00910Nitrogen metabolism2.97E-032P15104, P49448GLUL, GLUD2More
Hydrocortisone-cypionatehsa00970Aminoacyl-tRNA biosynthesis1.94E-033O95363, P14868, Q15046FARS2, DARS, KARSMore
Hydrocortisone-cypionatehsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Hydrocortisone-cypionatehsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Hydrocortisone-cypionatehsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Hydrocortisone-cypionatehsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Hydrocortisone-cypionatehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Hydrocortisone-cypionatehsa012102-Oxocarboxylic acid metabolism6.96E-041P50213IDH3AMore
Hydrocortisone-cypionatehsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Hydrocortisone-cypionatehsa03013RNA transport9.39E-059Q15287, Q9UBU9, P35658, P63279, P68104, P55884, O15371, P20042, Q14232RNPS1, NXF1, NUP214, UBE2I, EEF1A1, EIF3B, EIF3D, EIF2S2, EIF2B1More
Hydrocortisone-cypionatehsa03040Spliceosome1.81E-0616O43143, O60508, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Hydrocortisone-cypionatehsa03060Protein export9.07E-042P37108, Q15005SRP14, SPCS2More
Hydrocortisone-cypionatehsa04012ErbB signaling pathway3.57E-036P21860, Q13191, Q13557, P19174, O14944, P42338ERBB3, CBLB, CAMK2D, PLCG1, EREG, PIK3CBMore
Hydrocortisone-cypionatehsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Hydrocortisone-cypionatehsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Hydrocortisone-cypionatehsa04020Calcium signaling pathway2.19E-0510Q96DU7, Q08828, P45880, Q13557, P21860, P61073, P0DP24, P05141, P51828, P23634ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, CXCR4, CALM2, SLC25A5, ADCY7, ATP2B4More
Hydrocortisone-cypionatehsa04022cGMP-PKG signaling pathway2.45E-038Q99941, P18848, P23634, Q08828, P51828, P05141, P45880, P0DP24CREBL1, ATF4, ATP2B4, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2More
Hydrocortisone-cypionatehsa04060Cytokine-cytokine receptor interaction2.09E-028P14784, P14778, Q06643, Q13651, Q9HBE5, P09341, P19875, Q93038IL2RB, IL1R1, LTB, IL10RA, IL21R, CXCL1, CXCL2, TNFRSF25More
Hydrocortisone-cypionatehsa04061Viral protein interaction with cytokine and cytokine receptor9.15E-049Q8NHW4, P09341, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P01375CCL4L2, CXCL1, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, TNFMore
Hydrocortisone-cypionatehsa04062Chemokine signaling pathway3.82E-0515P25024, P25025, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P49841, Q8WYR1CXCR1, CXCR2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, GSK3B, PIK3R5More
Hydrocortisone-cypionatehsa04064NF-kappa B signaling pathway4.54E-0517P10415, Q13489, P14778, P01584, P29965, P19174, Q04759, Q9UDY8, P06239, Q8WV28, Q13315, P63279, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, IL1R1, IL1B, CD40LG, PLCG1, PRKCQ, MALT1, LCK, BLNK, ATM, UBE2I, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Hydrocortisone-cypionatehsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Hydrocortisone-cypionatehsa04071Sphingolipid signaling pathway4.49E-024P17252, Q13362, Q9BX95, P10415PRKCA, PPP2R5C, SGPP1, BCL2More
Hydrocortisone-cypionatehsa04072Phospholipase D signaling pathway1.78E-026P42338, P43657, P25024, P25025, Q14344, Q9GZP0PIK3CB, P2RY5, CXCR1, CXCR2, GNA13, PDGFDMore
Hydrocortisone-cypionatehsa04114Oocyte meiosis4.36E-025Q13557, P0DP24, Q08828, P51828, P27348CAMK2D, CALM2, ADCY1, ADCY7, YWHAQMore
Hydrocortisone-cypionatehsa04140Autophagy - animal1.76E-037Q9Y4H2, P42338, Q9NQL2, P22694, Q14643, Q9H1Y0, Q04759IRS2, PIK3CB, RRAGD, PRKACB, ITPR1, ATG5, PRKCQMore
Hydrocortisone-cypionatehsa04141Protein processing in endoplasmic reticulum4.34E-0410P07384, O95487, Q99941, O75460, P17861, P11142, Q9H3Z4, P07900, Q9NR31, O95816CAPN1, SEC24B, CREBL1, ERN1, XBP1, HSPA8, DNAJC5, HSP90AA1, SAR1A, BAG2More
Hydrocortisone-cypionatehsa04145Phagosome2.83E-049P60709, Q15075, Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765ACTB, EEA1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOBMore
Hydrocortisone-cypionatehsa04150mTOR signaling pathway2.72E-024P42338, Q9NQL2, Q13322, P49841PIK3CB, RRAGD, GRB10, GSK3BMore
Hydrocortisone-cypionatehsa04151PI3K-Akt signaling pathway5.33E-0320P42338, P43657, P25116, P20827, P49767, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, O60603, P14784, P01568, P10415, P17252, P30281PIK3CB, P2RY5, F2R, EFNA1, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, BCL2, PRKCA, CCND3More
Hydrocortisone-cypionatehsa04211Longevity regulating pathway4.98E-024Q08828, P51828, Q99941, P18848ADCY1, ADCY7, CREBL1, ATF4More
Hydrocortisone-cypionatehsa04213Longevity regulating pathway - multiple species1.56E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Hydrocortisone-cypionatehsa04217Necroptosis1.68E-0414P01568, P23458, Q13489, Q9NQC7, P42224, P05141, P01584, P0C0S5, Q6FI13, P10415, Q13557, Q9H444, O43633, Q08752IFNA21, JAK1, BIRC3, CYLD, STAT1, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, BCL2, CAMK2D, CHMP4B, CHMP2A, PPIDMore
Hydrocortisone-cypionatehsa04261Adrenergic signaling in cardiomyocytes1.49E-0412P09493, Q08828, P51828, Q99941, P18848, Q13362, P0DP23, P0DP24, Q13557, P17252, P10415, P23634TPM1, ADCY1, ADCY7, CREBL1, ATF4, PPP2R5C, CALM1, CALM2, CAMK2D, PRKCA, BCL2, ATP2B4More
Hydrocortisone-cypionatehsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Hydrocortisone-cypionatehsa04360Axon guidance2.74E-038P16333, P20827, O95631, P42338, P07332, P23528, P19174, Q06124NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1, PTPN11More
Hydrocortisone-cypionatehsa04370VEGF signaling pathway4.05E-022P19174, P42338PLCG1, PIK3CBMore
Hydrocortisone-cypionatehsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Hydrocortisone-cypionatehsa04380Osteoclast differentiation7.71E-0513P09603, Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P42338, P01584, P14778, O75015, P01375, Q8N149, P78324CSF1, CYLD, GAB2, MAPK14, JAK1, LCK, PIK3CB, IL1B, IL1R1, FCGR3B, TNF, LILRA2, SIRPAMore
Hydrocortisone-cypionatehsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Hydrocortisone-cypionatehsa04530Tight junction2.17E-033P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Hydrocortisone-cypionatehsa04540Gap junction1.29E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Hydrocortisone-cypionatehsa04612Antigen processing and presentation1.77E-0310P13765, P48382, P26715, P26717, Q07444, Q13241, P01732, P30101, P11142, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, PDIA3, HSPA8, TNFMore
Hydrocortisone-cypionatehsa04613Neutrophil extracellular trap formation2.29E-0318P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q16778, P68431, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST2H2BE, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Hydrocortisone-cypionatehsa04621NOD-like receptor signaling pathway1.85E-0210Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P29728, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4More
Hydrocortisone-cypionatehsa04623Cytosolic DNA-sensing pathway1.20E-022P01584, Q8NHW4IL1B, CCL4L2More
Hydrocortisone-cypionatehsa04625C-type lectin receptor signaling pathway3.04E-025Q9ULY5, P20749, P01375, Q13191, P42338CLEC4E, BCL3, TNF, CBLB, PIK3CBMore
Hydrocortisone-cypionatehsa04640Hematopoietic cell lineage5.34E-0412P13612, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P09564, P13765, P01375ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNFMore
Hydrocortisone-cypionatehsa04650Natural killer cell mediated cytotoxicity3.33E-0713P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Hydrocortisone-cypionatehsa04657IL-17 signaling pathway1.42E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Hydrocortisone-cypionatehsa04658Th1 and Th2 cell differentiation1.21E-0914Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Hydrocortisone-cypionatehsa04659Th17 cell differentiation3.81E-0917Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Hydrocortisone-cypionatehsa04660T cell receptor signaling pathway5.04E-0915P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Hydrocortisone-cypionatehsa04662B cell receptor signaling pathway4.96E-076P49841, P42338, P60033, P07948, P21854, Q8N149GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2More
Hydrocortisone-cypionatehsa04664Fc epsilon RI signaling pathway5.70E-056P01375, Q16539, P42338, P07948, P19174, P09917TNF, MAPK14, PIK3CB, LYN, PLCG1, ALOX5More
Hydrocortisone-cypionatehsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Hydrocortisone-cypionatehsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Hydrocortisone-cypionatehsa04713Circadian entrainment1.25E-038P0DP23, P0DP24, Q13557, P17252, P62873, Q14643, Q08828, P51828CALM1, CALM2, CAMK2D, PRKCA, GNB1, ITPR1, ADCY1, ADCY7More
Hydrocortisone-cypionatehsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Hydrocortisone-cypionatehsa04720Long-term potentiation1.63E-037P17252, Q13557, P0DP23, P0DP24, P18848, Q08828, Q14643PRKCA, CAMK2D, CALM1, CALM2, ATF4, ADCY1, ITPR1More
Hydrocortisone-cypionatehsa04722Neurotrophin signaling pathway9.39E-032Q05655, P52566PRKCD, ARHGDIBMore
Hydrocortisone-cypionatehsa04723Retrograde endocannabinoid signaling1.88E-038Q14643, P17252, P62873, P63218, P50151, P48058, Q16539, Q16718ITPR1, PRKCA, GNB1, GNG5, GNG10, GRIA4, MAPK14, NDUFA5More
Hydrocortisone-cypionatehsa04724Glutamatergic synapse7.09E-035P48058, P43003, P63218, P50151, P15104GRIA4, SLC1A3, GNG5, GNG10, GLULMore
Hydrocortisone-cypionatehsa04725Cholinergic synapse1.75E-038Q08828, P51828, Q14643, P17252, P62873, P18848, Q13557, P10415ADCY1, ADCY7, ITPR1, PRKCA, GNB1, ATF4, CAMK2D, BCL2More
Hydrocortisone-cypionatehsa04728Dopaminergic synapse1.89E-0416Q14643, P17252, P62873, P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, P0DP23, P0DP24, O15516, P48058ITPR1, PRKCA, GNB1, GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, CALM1, CALM2, CLOCK, GRIA4More
Hydrocortisone-cypionatehsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Hydrocortisone-cypionatehsa04750Inflammatory mediator regulation of TRP channels6.91E-0713P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2More
Hydrocortisone-cypionatehsa04911Insulin secretion2.95E-055Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Hydrocortisone-cypionatehsa04912GnRH signaling pathway5.97E-048P17252, Q08828, P51828, P18848, Q13557, Q14643, P0DP23, P0DP24PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, ITPR1, CALM1, CALM2More
Hydrocortisone-cypionatehsa04915Estrogen signaling pathway4.72E-024Q99941, P51828, P07900, P11142CREBL1, ADCY7, HSP90AA1, HSPA8More
Hydrocortisone-cypionatehsa04916Melanogenesis7.61E-034Q13557, P0DP24, Q08828, P51828CAMK2D, CALM2, ADCY1, ADCY7More
Hydrocortisone-cypionatehsa04918Thyroid hormone synthesis4.47E-035Q08828, P51828, Q99941, P18848, P02768ADCY1, ADCY7, CREBL1, ATF4, ALBMore
Hydrocortisone-cypionatehsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Hydrocortisone-cypionatehsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Hydrocortisone-cypionatehsa04924Renin secretion8.71E-033Q14643, Q13370, P0DP23ITPR1, PDE3B, CALM1More
Hydrocortisone-cypionatehsa04925Aldosterone synthesis and secretion8.00E-067Q99941, P18848, Q08828, P51828, P0DP24, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4More
Hydrocortisone-cypionatehsa04927Cortisol synthesis and secretion4.16E-034Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Hydrocortisone-cypionatehsa04928Parathyroid hormone synthesis, secretion and action3.77E-024Q08828, P51828, Q99941, P18848ADCY1, ADCY7, CREBL1, ATF4More
Hydrocortisone-cypionatehsa04930Type II diabetes mellitus2.68E-021Q05655PRKCDMore
Hydrocortisone-cypionatehsa04932Non-alcoholic fatty liver disease3.45E-025P18848, O75460, P01584, P12074, O15239ATF4, ERN1, IL1B, COX6A1, NDUFA1More
Hydrocortisone-cypionatehsa04933AGE-RAGE signaling pathway in diabetic complications1.19E-039P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Hydrocortisone-cypionatehsa04934Cushing syndrome2.69E-066Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Hydrocortisone-cypionatehsa04935Growth hormone synthesis, secretion and action4.98E-024Q08828, P51828, Q99941, P18848ADCY1, ADCY7, CREBL1, ATF4More
Hydrocortisone-cypionatehsa04966Collecting duct acid secretion2.86E-022Q13488, Q9Y666TCIRG1, SLC12A7More
Hydrocortisone-cypionatehsa04970Salivary secretion3.54E-023Q08828, P51828, P0DP24ADCY1, ADCY7, CALM2More
Hydrocortisone-cypionatehsa04971Gastric acid secretion2.95E-055Q08828, P51828, P15311, P0DP24, Q13557ADCY1, ADCY7, VIL2, CALM2, CAMK2DMore
Hydrocortisone-cypionatehsa04973Carbohydrate digestion and absorption2.44E-042O43451, P42338MGAM, PIK3CBMore
Hydrocortisone-cypionatehsa05010Alzheimer disease2.50E-0632Q92542, P01375, O15239, Q16718, O14521, P05496, Q06055, P12074, Q14643, Q00535, Q9NZJ5, O75460, P0DP23, P0DP24, Q13564, P49841, P01584, P18848, Q13509, P68371, O15169, Q92837, P09603, P42338, P05141, P21796, P45880, Q08752, P17861, P28070, P43686, P62195NCSTN, TNF, NDUFA1, NDUFA5, SDHD, ATP5G1, ATP5G2, COX6A1, ITPR1, CDK5, EIF2AK3, ERN1, CALM1, CALM2, APPBP1, GSK3B, IL1B, ATF4, TUBB3, TUBB2C, AXIN1, FRAT1, CSF1, PIK3CB, SLC25A5, VDAC1, VDAC2, PPID, XBP1, PSMB4, PSMC4, PSMC5More
Hydrocortisone-cypionatehsa05012Parkinson disease9.44E-0518O15239, Q16718, O14521, P12074, Q06055, P05141, O75460, P18848, P17861, P28070, P43686, P62195, Q14643, P0DP23, P0DP24, Q13557, Q13509, P68371NDUFA1, NDUFA5, SDHD, COX6A1, ATP5G2, SLC25A5, ERN1, ATF4, XBP1, PSMB4, PSMC4, PSMC5, ITPR1, CALM1, CALM2, CAMK2D, TUBB3, TUBB2CMore
Hydrocortisone-cypionatehsa05014Amyotrophic lateral sclerosis1.01E-023Q06055, P17861, P62195ATP5G2, XBP1, PSMC5More
Hydrocortisone-cypionatehsa05016Huntington disease3.54E-028O15239, P12074, P24928, P62487, P05141, O75460, P28070, P43686NDUFA1, COX6A1, POLR2A, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4More
Hydrocortisone-cypionatehsa05017Spinocerebellar ataxia1.42E-022P17861, P62195XBP1, PSMC5More
Hydrocortisone-cypionatehsa05020Prion disease9.80E-0519P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P12074, Q14643, P18848, P05141, P45880, P28070, P43686, Q13509, P68371, Q99941, P14598, Q15080IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX6A1, ITPR1, ATF4, SLC25A5, VDAC2, PSMB4, PSMC4, TUBB3, TUBB2C, CREBL1, NCF1, NCF4More
Hydrocortisone-cypionatehsa05022Pathways of neurodegeneration - multiple diseases8.91E-0626Q14643, Q13509, P68371, P10415, O15239, Q16718, O14521, P12074, Q06055, Q8TEV9, O75460, P18848, P17861, Q13561, P05141, P17252, Q00535, O15169, P01584, Q08752, P0DP23, P0DP24, Q13557, P28070, P43686, P62195ITPR1, TUBB3, TUBB2C, BCL2, NDUFA1, NDUFA5, SDHD, COX6A1, ATP5G2, SMCR8, ERN1, ATF4, XBP1, DCTN2, SLC25A5, PRKCA, CDK5, AXIN1, IL1B, PPID, CALM1, CALM2, CAMK2D, PSMB4, PSMC4, PSMC5More
Hydrocortisone-cypionatehsa05030Cocaine addiction3.54E-023Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Hydrocortisone-cypionatehsa05031Amphetamine addiction7.61E-034P0DP24, Q13557, Q99941, P18848CALM2, CAMK2D, CREBL1, ATF4More
Hydrocortisone-cypionatehsa05110Vibrio cholerae infection4.50E-034Q13488, P17252, P19174, P60709TCIRG1, PRKCA, PLCG1, ACTBMore
Hydrocortisone-cypionatehsa05120Epithelial cell signaling in Helicobacter pylori infection3.24E-037Q16539, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Hydrocortisone-cypionatehsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Hydrocortisone-cypionatehsa05131Shigellosis3.99E-0310P68431, Q05655, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752, P07737H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID, PFN1More
Hydrocortisone-cypionatehsa05132Salmonella infection6.68E-0310Q9UJU2, P84095, Q13489, P10415, P07737, O60603, Q9BQS8, Q13561, Q13509, P68371LEF1, RHOG, BIRC3, BCL2, PFN1, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Hydrocortisone-cypionatehsa05134Legionellosis2.92E-046Q9NR31, P11215, P68104, P11142, P09341, P19875SAR1A, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2More
Hydrocortisone-cypionatehsa05135Yersinia infection1.92E-059P13612, P06239, P19174, Q16539, P01375, P42338, P49841, P01730, P01732ITGA4, LCK, PLCG1, MAPK14, TNF, PIK3CB, GSK3B, CD4, CD8AMore
Hydrocortisone-cypionatehsa05140Leishmaniasis3.96E-0511P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, Q15080ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, NCF4More
Hydrocortisone-cypionatehsa05144Malaria8.80E-035P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Hydrocortisone-cypionatehsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Hydrocortisone-cypionatehsa05146Amoebiasis1.08E-0712P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Hydrocortisone-cypionatehsa05152Tuberculosis7.93E-048Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1More
Hydrocortisone-cypionatehsa05163Human cytomegalovirus infection8.47E-1024P42338, P01375, P30511, P63218, P50151, Q14643, P0DP24, Q14344, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, Q99941, P18848, O00463, P30101PIK3CB, TNF, HLA-F, GNG5, GNG10, ITPR1, CALM2, GNA13, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TRAF5, PDIA3More
Hydrocortisone-cypionatehsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Hydrocortisone-cypionatehsa05167Kaposi sarcoma-associated herpesvirus infection4.73E-026P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1More
Hydrocortisone-cypionatehsa05169Epstein-Barr virus infection5.97E-0412Q13547, O00463, Q16539, P42338, P07948, P30511, P30101, Q13761, P24522, P01375, P07766, P20963HDAC1, TRAF5, MAPK14, PIK3CB, LYN, HLA-F, PDIA3, RUNX3, GADD45A, TNF, CD3E, CD247More
Hydrocortisone-cypionatehsa05170Human immunodeficiency virus 1 infection3.27E-0418P42338, P30511, P62873, P63218, P50151, P0DP23, P01375, P17252, O00463, P30101, Q14643, P01568, O60603, Q13315, P07766, P20963, P10415, Q9Y6Q5PIK3CB, HLA-F, GNB1, GNG5, GNG10, CALM1, TNF, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, TLR2, ATM, CD3E, CD247, BCL2, AP1M2More
Hydrocortisone-cypionatehsa05200Pathways in cancer1.55E-0328Q13751, P42338, P08238, P42224, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P49767, Q12778, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, FOXO1, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RBMore
Hydrocortisone-cypionatehsa05202Transcriptional misregulation in cancer3.51E-0212P14780, P27930, Q15744, Q16548, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45AMore
Hydrocortisone-cypionatehsa05203Viral carcinogenesis4.62E-023Q12933, P42229, Q15283TRAF2, STAT5A, RASA2More
Hydrocortisone-cypionatehsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Hydrocortisone-cypionatehsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Hydrocortisone-cypionatehsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Hydrocortisone-cypionatehsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Hydrocortisone-cypionatehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Hydrocortisone-cypionatehsa05221Acute myeloid leukemia4.95E-023P42338, Q15744, P11215PIK3CB, CEBPE, ITGAMMore
Hydrocortisone-cypionatehsa05223Non-small cell lung cancer3.99E-024P17252, O43524, P19174, O75293PRKCA, FOXO3, PLCG1, GADD45BMore
Hydrocortisone-cypionatehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Hydrocortisone-cypionatehsa05231Choline metabolism in cancer3.99E-024P19174, P23743, O14494, P17252PLCG1, DGKA, PLPP1, PRKCAMore
Hydrocortisone-cypionatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer5.72E-0611P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4More
Hydrocortisone-cypionatehsa05310Asthma1.62E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Hydrocortisone-cypionatehsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Hydrocortisone-cypionatehsa05321Inflammatory bowel disease1.09E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Hydrocortisone-cypionatehsa05322Systemic lupus erythematosus4.18E-037P08246, P09871, P10747, P13765, P29965, Q6FI13, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Hydrocortisone-cypionatehsa05323Rheumatoid arthritis1.59E-037Q06643, P13765, Q13488, P10747, P09341, P19875, O60603LTB, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2More
Hydrocortisone-cypionatehsa05330Allograft rejection1.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Hydrocortisone-cypionatehsa05332Graft-versus-host disease1.76E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Hydrocortisone-cypionatehsa05340Primary immunodeficiency4.95E-023P01732, P07766, P06239CD8A, CD3E, LCKMore
Hydrocortisone-cypionatehsa05415Diabetic cardiomyopathy3.66E-037P17252, P14598, Q15080, Q16718, O14521, P04406, P11413PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDH, G6PDMore
Hydrocortisone-cypionatehsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Hydrocortisone-cypionatehsa05418Fluid shear stress and atherosclerosis3.02E-026P42338, Q14145, P10599, P01375, P14778, P27930PIK3CB, KEAP1, TXN, TNF, IL1R1, IL1R2More

Community members of Hydrocortisone-cypionate (SDC: 4.19)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)