PharmaCoNets

Pentose phosphate pathway

8.97E-03

P11413

G6PD

Hydrocortisone-acetate

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Hydrocortisone-acetate

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Hydrocortisone-acetate

Arginine biosynthesis

1.94E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
P60033	CD81	CD81 antigen	P15104	GLUL	Glutamine synthetase	-0.841
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
P60033	CD81	CD81 antigen	P05089	ARG1	Arginase-1	-0.782
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
P60033	CD81	CD81 antigen	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755

Hydrocortisone-acetate

Alanine, aspartate and glutamate metabolism

4.32E-02

P49448, P15104

GLUD2, GLUL

Hydrocortisone-acetate

Glutathione metabolism

2.60E-05

Q9UJ14, P11413, Q16772, P09211, P30041

GGTL3, G6PD, GSTA3, GSTP1, PRDX6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75

Hydrocortisone-acetate

Starch and sucrose metabolism

2.51E-06

O43451, P46976, P06737

MGAM, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887

Hydrocortisone-acetate

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Hydrocortisone-acetate

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Hydrocortisone-acetate

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Hydrocortisone-acetate

Thiamine metabolism

5.11E-05

P05186, P24666

ALPL, ACP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7

Hydrocortisone-acetate

Nitrogen metabolism

4.32E-02

P15104, P49448

GLUL, GLUD2

Hydrocortisone-acetate

Aminoacyl-tRNA biosynthesis

1.21E-02

P14868

DARS

Hydrocortisone-acetate

Metabolism of xenobiotics by cytochrome P450

9.14E-05

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Hydrocortisone-acetate

Drug metabolism - cytochrome P450

1.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Hydrocortisone-acetate

Drug metabolism - other enzymes

8.59E-04

P32320, P05164, Q16772, P09211

CDA, MPO, GSTA3, GSTP1

Hydrocortisone-acetate

Metabolic pathways

3.55E-03

Q9NR34, P35790, P05089, Q16772, P09211, Q9UJ14, P30041, P32320, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, Q7KZN9, P05186, P24666, P15121, Q9HCC0, P33121, Q9UHK6, Q86VZ5, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q9BQB6

MAN1C1, CHKA, ARG1, GSTA3, GSTP1, GGTL3, PRDX6, CDA, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, COX15, ALPL, ACP1, AKR1B1, MCCC2, ACSL1, AMACR, SGMS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, VKORC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731

Hydrocortisone-acetate

Carbon metabolism

2.91E-02

P11413

G6PD

Hydrocortisone-acetate

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Hydrocortisone-acetate

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Hydrocortisone-acetate

RNA transport

9.39E-05

Q15287, Q9UBU9, P35658, P63279, P68104, P55884, O15371, P20042, Q14232

RNPS1, NXF1, NUP214, UBE2I, EEF1A1, EIF3B, EIF3D, EIF2S2, EIF2B1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716

Hydrocortisone-acetate

Spliceosome

3.98E-02

Q15427, P38159, P61978, P11142

SF3B4, RBMX, HNRPK, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Hydrocortisone-acetate

Protein export

9.07E-04

P37108, Q15005

SRP14, SPCS2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726

Hydrocortisone-acetate

ErbB signaling pathway

3.74E-02

P21860, Q13557, O14944

ERBB3, CAMK2D, EREG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738

Hydrocortisone-acetate

Calcium signaling pathway

2.19E-05

Q96DU7, Q08828, P45880, Q13557, P21860, P61073, P0DP24, P05141, P51828, P23634

ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, CXCR4, CALM2, SLC25A5, ADCY7, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone-acetate

cGMP-PKG signaling pathway

2.45E-03

Q99941, P18848, P23634, Q08828, P51828, P05141, P45880, P0DP24

CREBL1, ATF4, ATP2B4, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone-acetate

Viral protein interaction with cytokine and cytokine receptor

9.15E-04

Q8NHW4, P09341, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P01375

CCL4L2, CXCL1, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-acetate

Chemokine signaling pathway

3.13E-02

P25024, P25025, P07948, P42338, P63218, P50151, P49407, P49841

CXCR1, CXCR2, LYN, PIK3CB, GNG5, GNG10, ARRB1, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Hydrocortisone-acetate

NF-kappa B signaling pathway

1.32E-06

P10415, Q13489, O00463, Q13546, P14778, P01584, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q9UNE0, Q9NQC7

BCL2, BIRC3, TRAF5, RIPK1, IL1R1, IL1B, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, EDAR, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805

Hydrocortisone-acetate

Sphingolipid signaling pathway

7.26E-04

P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2

S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866

Hydrocortisone-acetate

hsa04080

Neuroactive ligand-receptor interaction

1.00E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883

Hydrocortisone-acetate

Oocyte meiosis

4.36E-02

Q13557, P0DP24, Q08828, P51828, P27348

CAMK2D, CALM2, ADCY1, ADCY7, YWHAQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751

Hydrocortisone-acetate

hsa04120

Ubiquitin mediated proteolysis

2.57E-02

Q14145, Q13042, Q93034, Q15751

KEAP1, CDC16, CUL5, HERC1

Hydrocortisone-acetate

Autophagy - animal

3.05E-03

Q9NQL2, P22694, Q14643, P10415, Q9H1Y0, Q04759

RRAGD, PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	-0.701
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906

Hydrocortisone-acetate

Protein processing in endoplasmic reticulum

5.75E-03

Q99941, O75460, P17861, P11142, Q9H3Z4, P07900, Q9NR31

CREBL1, ERN1, XBP1, HSPA8, DNAJC5, HSP90AA1, SAR1A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791

Hydrocortisone-acetate

Phagosome

4.48E-02

Q15080, P05164, O60603, P35443, P13765

NCF4, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709

Hydrocortisone-acetate

mTOR signaling pathway

2.72E-02

P42338, Q9NQL2, Q13322, P49841

PIK3CB, RRAGD, GRB10, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Hydrocortisone-acetate

Apoptosis

4.11E-03

Q13315, P10415, O76075, P01375, Q9NR28, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701

Hydrocortisone-acetate

Longevity regulating pathway

3.41E-03

Q12778, Q08828, P51828, Q99941, P18848, Q9UEF7, Q96KQ7

FOXO1, ADCY1, ADCY7, CREBL1, ATF4, KL, EHMT2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72

Hydrocortisone-acetate

Longevity regulating pathway - multiple species

2.85E-02

Q9Y4H2, Q13547

IRS2, HDAC1

Hydrocortisone-acetate

Necroptosis

6.23E-04

P01568, P23458, Q13489, Q9NQC7, Q13546, P05141, P01584, P0C0S5, Q13557, Q9H444

IFNA21, JAK1, BIRC3, CYLD, RIPK1, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716

Hydrocortisone-acetate

Adrenergic signaling in cardiomyocytes

1.60E-03

Q08828, P51828, Q99941, P18848, P0DP24, Q13557, P23634

ADCY1, ADCY7, CREBL1, ATF4, CALM2, CAMK2D, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone-acetate

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Hydrocortisone-acetate

Hedgehog signaling pathway

2.61E-03

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Hydrocortisone-acetate

Osteoclast differentiation

6.08E-03

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P42338, P01584, P14778, O75015, Q8N149

CYLD, GAB2, MAPK14, JAK1, LCK, PIK3CB, IL1B, IL1R1, FCGR3B, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764

Hydrocortisone-acetate

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Hydrocortisone-acetate

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Hydrocortisone-acetate

Antigen processing and presentation

9.00E-05

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P30511, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, HLA-F, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-acetate

Neutrophil extracellular trap formation

1.04E-05

P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, O43315, Q16539

ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805

Hydrocortisone-acetate

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Hydrocortisone-acetate

NOD-like receptor signaling pathway

4.42E-05

Q16539, Q14643, P52630, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, Q13546, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838

MAPK14, ITPR1, STAT2, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P12838	DEFA4	Neutrophil defensin 4	-0.754
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P12838	DEFA4	Neutrophil defensin 4	-0.754
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899

Hydrocortisone-acetate

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Hydrocortisone-acetate

Cytosolic DNA-sensing pathway

5.86E-05

P01584, P01568, Q13546, Q8NHW4

IL1B, IFNA21, RIPK1, CCL4L2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766

Hydrocortisone-acetate

C-type lectin receptor signaling pathway

2.17E-02

P52630, P20749, P01375

STAT2, BCL3, TNF

Hydrocortisone-acetate

Hematopoietic cell lineage

1.10E-02

P13612, P14778, P27930, P15144, P25063, P09693, P01732, P13765, P01375

ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P24723	PRKCH	Protein kinase C eta type	P25063	CD24	Signal transducer CD24	-0.838
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P09564	CD7	T-cell antigen CD7	0.865
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-acetate

Natural killer cell mediated cytotoxicity

3.18E-05

P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715

TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.835
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P24723	PRKCH	Protein kinase C eta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.822
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P24723	PRKCH	Protein kinase C eta type	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.828
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83

Hydrocortisone-acetate

IL-17 signaling pathway

3.07E-05

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.708
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.708
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-acetate

Th1 and Th2 cell differentiation

2.17E-08

Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P24723	PRKCH	Protein kinase C eta type	Q13761	RUNX3	Runt-related transcription factor 3	0.915
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725

Hydrocortisone-acetate

Th17 cell differentiation

8.69E-06

Q04759, Q16539, P01730, P06239, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, MAPK14, CD4, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877

Hydrocortisone-acetate

T cell receptor signaling pathway

2.32E-06

P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743

Hydrocortisone-acetate

B cell receptor signaling pathway

2.80E-03

P49841, P42338, P60033, P07948, P21854, Q8N149

GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P24723	PRKCH	Protein kinase C eta type	P60033	CD81	CD81 antigen	0.711
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P24723	PRKCH	Protein kinase C eta type	P21854	CD72	B-cell differentiation antigen CD72	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
P24723	PRKCH	Protein kinase C eta type	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.765
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764

Hydrocortisone-acetate

Fc epsilon RI signaling pathway

1.80E-02

Q16539, P42338, P07948, P09917

MAPK14, PIK3CB, LYN, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796

Hydrocortisone-acetate

TNF signaling pathway

4.74E-02

Q99941, P01584, O95429

CREBL1, IL1B, BAG4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756

Hydrocortisone-acetate

Circadian entrainment

1.91E-02

P0DP24, Q13557, Q08828, P51828

CALM2, CAMK2D, ADCY1, ADCY7

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815

Hydrocortisone-acetate

Long-term potentiation

1.91E-02

Q13557, P0DP24, P18848, Q08828

CAMK2D, CALM2, ATF4, ADCY1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75

Hydrocortisone-acetate

Retrograde endocannabinoid signaling

3.86E-02

P63218, P50151, P48058, Q16539

GNG5, GNG10, GRIA4, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817

Hydrocortisone-acetate

Glutamatergic synapse

7.09E-03

P48058, P43003, P63218, P50151, P15104

GRIA4, SLC1A3, GNG5, GNG10, GLUL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84

Hydrocortisone-acetate

Cholinergic synapse

3.77E-02

Q08828, P51828, P18848, Q13557

ADCY1, ADCY7, ATF4, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725

Hydrocortisone-acetate

Dopaminergic synapse

1.73E-03

P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407, P0DP24, O15516, P48058

GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, CALM2, CLOCK, GRIA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701

Hydrocortisone-acetate

Inflammatory mediator regulation of TRP channels

7.58E-05

P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, Q14643, Q04759, P0DP24

IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, ITPR1, PRKCQ, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P24723	PRKCH	Protein kinase C eta type	P24723	PRKCH	Protein kinase C eta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone-acetate

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Hydrocortisone-acetate

Insulin secretion

2.95E-05

Q08828, P51828, Q99941, P18848, Q13557

ADCY1, ADCY7, CREBL1, ATF4, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone-acetate

GnRH signaling pathway

6.99E-03

Q08828, P51828, P18848, Q13557, P0DP24

ADCY1, ADCY7, ATF4, CAMK2D, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone-acetate

Estrogen signaling pathway

4.72E-02

Q99941, P51828, P07900, P11142

CREBL1, ADCY7, HSP90AA1, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Hydrocortisone-acetate

Melanogenesis

7.61E-03

Q13557, P0DP24, Q08828, P51828

CAMK2D, CALM2, ADCY1, ADCY7

Hydrocortisone-acetate

Thyroid hormone synthesis

4.47E-03

Q08828, P51828, Q99941, P18848, P02768

ADCY1, ADCY7, CREBL1, ATF4, ALB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718

Hydrocortisone-acetate

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Hydrocortisone-acetate

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Hydrocortisone-acetate

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Hydrocortisone-acetate

Aldosterone synthesis and secretion

8.00E-06

Q99941, P18848, Q08828, P51828, P0DP24, Q13557, P23634

CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone-acetate

Cortisol synthesis and secretion

4.16E-03

Q99941, P18848, Q08828, P51828

CREBL1, ATF4, ADCY1, ADCY7

Hydrocortisone-acetate

Parathyroid hormone synthesis, secretion and action

3.92E-03

Q14643, Q08828, P51828, P22694, P23771, Q99941, P18848, P10415

ITPR1, ADCY1, ADCY7, PRKACB, GATA3, CREBL1, ATF4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749

Hydrocortisone-acetate

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Hydrocortisone-acetate

Non-alcoholic fatty liver disease

3.45E-02

P18848, O75460, P01584, P12074, O15239

ATF4, ERN1, IL1B, COX6A1, NDUFA1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783

Hydrocortisone-acetate

Cushing syndrome

2.69E-06

Q99941, P18848, Q08828, P51828, O15169, Q13557

CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone-acetate

Growth hormone synthesis, secretion and action

4.98E-02

Q08828, P51828, Q99941, P18848

ADCY1, ADCY7, CREBL1, ATF4

Hydrocortisone-acetate

hsa04940

Type I diabetes mellitus

1.58E-02

P30511, P01375

HLA-F, TNF

Hydrocortisone-acetate

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Hydrocortisone-acetate

Collecting duct acid secretion

4.93E-02

P00918

CA2

Hydrocortisone-acetate

Salivary secretion

3.54E-02

Q08828, P51828, P0DP24

ADCY1, ADCY7, CALM2

Hydrocortisone-acetate

Gastric acid secretion

2.95E-05

Q08828, P51828, P15311, P0DP24, Q13557

ADCY1, ADCY7, VIL2, CALM2, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone-acetate

Carbohydrate digestion and absorption

1.57E-02

O43451, P42338

MGAM, PIK3CB

Hydrocortisone-acetate

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Hydrocortisone-acetate

Bile secretion

2.44E-02

P22694, P08183

PRKACB, ABCB1

Hydrocortisone-acetate

Alzheimer disease

2.56E-05

Q92542, O15239, P05496, Q06055, P12074, Q00535, O75460, P0DP24, P01584, P18848, O15169, P05141, P45880, P17861, P28070, P43686, P62195

NCSTN, NDUFA1, ATP5G1, ATP5G2, COX6A1, CDK5, ERN1, CALM2, IL1B, ATF4, AXIN1, SLC25A5, VDAC2, XBP1, PSMB4, PSMC4, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814

Hydrocortisone-acetate

Parkinson disease

5.28E-04

O15239, P12074, Q06055, P05141, O75460, P18848, P17861, P28070, P43686, P62195, P0DP24, Q13557

NDUFA1, COX6A1, ATP5G2, SLC25A5, ERN1, ATF4, XBP1, PSMB4, PSMC4, PSMC5, CALM2, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725

Hydrocortisone-acetate

Amyotrophic lateral sclerosis

1.01E-02

Q06055, P17861, P62195

ATP5G2, XBP1, PSMC5

Hydrocortisone-acetate

Huntington disease

3.54E-02

O15239, P12074, P24928, P62487, P05141, O75460, P28070, P43686

NDUFA1, COX6A1, POLR2A, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723

Hydrocortisone-acetate

Spinocerebellar ataxia

1.42E-02

P17861, P62195

XBP1, PSMC5

Hydrocortisone-acetate

Prion disease

1.76E-03

P01584, P46531, P11142, O15239, P05496, P12074, P18848, P05141, P45880, P28070, P43686, Q99941

IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX6A1, ATF4, SLC25A5, VDAC2, PSMB4, PSMC4, CREBL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769

Hydrocortisone-acetate

Pathways of neurodegeneration - multiple diseases

2.12E-04

O15239, P12074, Q06055, Q8TEV9, O75460, P18848, P17861, P05141, Q00535, O15169, P01584, P0DP24, Q13557, P28070, P43686, P62195

NDUFA1, COX6A1, ATP5G2, SMCR8, ERN1, ATF4, XBP1, SLC25A5, CDK5, AXIN1, IL1B, CALM2, CAMK2D, PSMB4, PSMC4, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814

Hydrocortisone-acetate

Cocaine addiction

3.54E-02

Q00535, Q99941, P18848

CDK5, CREBL1, ATF4

Hydrocortisone-acetate

Amphetamine addiction

7.61E-03

P0DP24, Q13557, Q99941, P18848

CALM2, CAMK2D, CREBL1, ATF4

Hydrocortisone-acetate

Alcoholism

2.05E-05

Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431

HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Hydrocortisone-acetate

Epithelial cell signaling in Helicobacter pylori infection

1.61E-03

Q16539, P09341, P25024, P25025, P07948

MAPK14, CXCL1, CXCR1, CXCR2, LYN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795

Hydrocortisone-acetate

Salmonella infection

9.85E-03

Q13546, Q13489, O60282, P68371

RIPK1, BIRC3, KIF5C, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
Q05655	PRKCD	Protein kinase C delta type	P84095	RHOG	Rho-related GTP-binding protein RhoG	0.71
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
Q05655	PRKCD	Protein kinase C delta type	P84095	RHOG	Rho-related GTP-binding protein RhoG	0.71
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747

Hydrocortisone-acetate

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Hydrocortisone-acetate

Legionellosis

5.53E-03

Q9NR31, P68104

SAR1A, EEF1A1

Hydrocortisone-acetate

Yersinia infection

1.11E-03

P13612, P06239, Q16539, P01375, P42338, P49841, P01730, P01732

ITGA4, LCK, MAPK14, TNF, PIK3CB, GSK3B, CD4, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77

Hydrocortisone-acetate

Leishmaniasis

1.99E-03

P13612, O75015, P13765, O60603, P01375, P49006, Q16539

ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MARCKSL1, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754

Hydrocortisone-acetate

hsa05143

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Hydrocortisone-acetate

Malaria

9.96E-05

P60033, P69905, P68871, O60603, P01375, P35443, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919

Hydrocortisone-acetate

Amoebiasis

1.14E-04

P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311

CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P24723	PRKCH	Protein kinase C eta type	P05089	ARG1	Arginase-1	-0.749
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P24723	PRKCH	Protein kinase C eta type	P12814	ACTN1	Alpha-actinin-1	-0.869
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P24723	PRKCH	Protein kinase C eta type	P08311	CTSG	Cathepsin G	-0.744
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867

Hydrocortisone-acetate

Staphylococcus aureus infection

1.02E-03

P21730, P21462, O75015, P59665, P59666, P12838, P49913

C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774

Hydrocortisone-acetate

hsa05160

Hepatitis C

9.27E-03

P52630, P60033, P49841, P01375

STAT2, CD81, GSK3B, TNF

Hydrocortisone-acetate

Human cytomegalovirus infection

1.21E-07

P42338, P01375, P63218, P50151, Q14643, P0DP24, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463

PIK3CB, TNF, GNG5, GNG10, ITPR1, CALM2, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896

Hydrocortisone-acetate

Human papillomavirus infection

1.76E-02

P49841, P24821, P01375, P52630, P30511

GSK3B, TNC, TNF, STAT2, HLA-F

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P17252	PRKCA	Protein kinase C alpha type	Q05086	UBE3A	Ubiquitin-protein ligase E3A	0.703
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P17252	PRKCA	Protein kinase C alpha type	Q05086	UBE3A	Ubiquitin-protein ligase E3A	0.703
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739

Hydrocortisone-acetate

Epstein-Barr virus infection

2.32E-02

Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, P07766, P20963

HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775

Hydrocortisone-acetate

Transcriptional misregulation in cancer

4.24E-04

Q12778, Q13315, P14780, P27930, Q15744, Q16548, P11215, O15550, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522

FOXO1, ATM, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, UTX, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863

Hydrocortisone-acetate

Viral carcinogenesis

2.10E-04

Q12933, P42229, Q13547, Q15283, P58876, P62807, Q16778, O60814

TRAF2, STAT5A, HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Hydrocortisone-acetate

Chemical carcinogenesis

1.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Hydrocortisone-acetate

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769

Hydrocortisone-acetate

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Hydrocortisone-acetate

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Hydrocortisone-acetate

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Hydrocortisone-acetate

PD-L1 expression and PD-1 checkpoint pathway in cancer

7.43E-06

P42338, O95267, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, P01730

PIK3CB, RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84

Hydrocortisone-acetate

Asthma

5.14E-04

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Hydrocortisone-acetate

Inflammatory bowel disease

3.54E-06

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832

Hydrocortisone-acetate

Systemic lupus erythematosus

4.80E-06

P09871, Q93077, P58876, P62807, Q16778, O60814, P68431

C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Hydrocortisone-acetate

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Hydrocortisone-acetate

Allograft rejection

2.30E-02

P30511, P01375

HLA-F, TNF

Hydrocortisone-acetate

Graft-versus-host disease

1.82E-05

P13765, P30511, P10747, P01375, P26715, Q13241

HLA-DOB, HLA-F, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84

Hydrocortisone-acetate

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Hydrocortisone-acetate

Diabetic cardiomyopathy

3.59E-02

P11413

G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1

Hydrocortisone-acetate

hsa05418

Fluid shear stress and atherosclerosis

3.86E-03

Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2

Hydrocortisone-butyrate

Pentose phosphate pathway

8.97E-03

P11413

G6PD

Hydrocortisone-butyrate

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Hydrocortisone-butyrate

Arginine biosynthesis

1.94E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
P60033	CD81	CD81 antigen	P15104	GLUL	Glutamine synthetase	-0.841
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
P60033	CD81	CD81 antigen	P05089	ARG1	Arginase-1	-0.782
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
P60033	CD81	CD81 antigen	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755

Hydrocortisone-butyrate

Alanine, aspartate and glutamate metabolism

4.32E-02

P49448, P15104

GLUD2, GLUL

Hydrocortisone-butyrate

Glutathione metabolism

2.60E-05

Q9UJ14, P11413, Q16772, P09211, P30041

GGTL3, G6PD, GSTA3, GSTP1, PRDX6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75

Hydrocortisone-butyrate

Starch and sucrose metabolism

7.23E-05

O43451, P46976, P06737

MGAM, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887

Hydrocortisone-butyrate

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Hydrocortisone-butyrate

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Hydrocortisone-butyrate

Thiamine metabolism

6.40E-04

P05186, P24666

ALPL, ACP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7

Hydrocortisone-butyrate

Nitrogen metabolism

4.32E-02

P15104, P49448

GLUL, GLUD2

Hydrocortisone-butyrate

Aminoacyl-tRNA biosynthesis

1.21E-02

P14868

DARS

Hydrocortisone-butyrate

Metabolism of xenobiotics by cytochrome P450

9.14E-05

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Hydrocortisone-butyrate

Drug metabolism - cytochrome P450

1.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Hydrocortisone-butyrate

Drug metabolism - other enzymes

8.59E-04

P32320, P05164, Q16772, P09211

CDA, MPO, GSTA3, GSTP1

Hydrocortisone-butyrate

Metabolic pathways

8.43E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731

Hydrocortisone-butyrate

Carbon metabolism

2.91E-02

P11413

G6PD

Hydrocortisone-butyrate

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Hydrocortisone-butyrate

RNA transport

9.39E-05

Q15287, Q9UBU9, P35658, P63279, P68104, P55884, O15371, P20042, Q14232

RNPS1, NXF1, NUP214, UBE2I, EEF1A1, EIF3B, EIF3D, EIF2S2, EIF2B1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716

Hydrocortisone-butyrate

Spliceosome

3.98E-02

Q15427, P38159, P61978, P11142

SF3B4, RBMX, HNRPK, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Hydrocortisone-butyrate

Protein export

9.07E-04

P37108, Q15005

SRP14, SPCS2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726

Hydrocortisone-butyrate

ErbB signaling pathway

3.74E-02

P21860, Q13557, O14944

ERBB3, CAMK2D, EREG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738

Hydrocortisone-butyrate

Calcium signaling pathway

2.19E-05

Q96DU7, Q08828, P45880, Q13557, P21860, P61073, P0DP24, P05141, P51828, P23634

ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, CXCR4, CALM2, SLC25A5, ADCY7, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone-butyrate

cGMP-PKG signaling pathway

2.45E-03

Q99941, P18848, P23634, Q08828, P51828, P05141, P45880, P0DP24

CREBL1, ATF4, ATP2B4, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone-butyrate

Viral protein interaction with cytokine and cytokine receptor

9.15E-04

Q8NHW4, P09341, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P01375

CCL4L2, CXCL1, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-butyrate

Chemokine signaling pathway

3.13E-02

P25024, P25025, P07948, P42338, P63218, P50151, P49407, P49841

CXCR1, CXCR2, LYN, PIK3CB, GNG5, GNG10, ARRB1, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Hydrocortisone-butyrate

NF-kappa B signaling pathway

1.06E-05

P10415, Q13489, O00463, Q13546, P01584, Q04759, Q9UDY8, Q16548, Q13315, P63279, P24522, Q8NHW4, P09341, Q9UNE0, Q9NQC7

BCL2, BIRC3, TRAF5, RIPK1, IL1B, PRKCQ, MALT1, BCL2A1, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, EDAR, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805

Hydrocortisone-butyrate

Sphingolipid signaling pathway

7.26E-04

P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2

S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866

Hydrocortisone-butyrate

hsa04080

Neuroactive ligand-receptor interaction

1.00E-02

P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883

Hydrocortisone-butyrate

Oocyte meiosis

4.36E-02

Q13557, P0DP24, Q08828, P51828, P27348

CAMK2D, CALM2, ADCY1, ADCY7, YWHAQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751

Hydrocortisone-butyrate

hsa04120

Ubiquitin mediated proteolysis

2.57E-02

Q14145, Q13042, Q93034, Q15751

KEAP1, CDC16, CUL5, HERC1

Hydrocortisone-butyrate

Autophagy - animal

3.05E-03

Q9NQL2, P22694, Q14643, P10415, Q9H1Y0, Q04759

RRAGD, PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	-0.701
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906

Hydrocortisone-butyrate

Protein processing in endoplasmic reticulum

5.75E-03

Q99941, O75460, P17861, P11142, Q9H3Z4, P07900, Q9NR31

CREBL1, ERN1, XBP1, HSPA8, DNAJC5, HSP90AA1, SAR1A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791

Hydrocortisone-butyrate

Phagosome

4.48E-02

Q15080, P05164, O60603, P35443, P13765

NCF4, MPO, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709

Hydrocortisone-butyrate

mTOR signaling pathway

2.72E-02

P42338, Q9NQL2, Q13322, P49841

PIK3CB, RRAGD, GRB10, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Hydrocortisone-butyrate

Apoptosis

4.11E-03

Q13315, P10415, O76075, P01375, Q9NR28, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701

Hydrocortisone-butyrate

Longevity regulating pathway

3.41E-03

Q12778, Q08828, P51828, Q99941, P18848, Q9UEF7, Q96KQ7

FOXO1, ADCY1, ADCY7, CREBL1, ATF4, KL, EHMT2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72

Hydrocortisone-butyrate

Longevity regulating pathway - multiple species

2.85E-02

Q9Y4H2, Q13547

IRS2, HDAC1

Hydrocortisone-butyrate

Necroptosis

6.23E-04

P01568, P23458, Q13489, Q9NQC7, Q13546, P05141, P01584, P0C0S5, Q13557, Q9H444

IFNA21, JAK1, BIRC3, CYLD, RIPK1, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716

Hydrocortisone-butyrate

Adrenergic signaling in cardiomyocytes

1.60E-03

Q08828, P51828, Q99941, P18848, P0DP24, Q13557, P23634

ADCY1, ADCY7, CREBL1, ATF4, CALM2, CAMK2D, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone-butyrate

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Hydrocortisone-butyrate

Hedgehog signaling pathway

2.61E-03

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Hydrocortisone-butyrate

Osteoclast differentiation

6.08E-03

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P42338, P01584, P14778, O75015, Q8N149

CYLD, GAB2, MAPK14, JAK1, LCK, PIK3CB, IL1B, IL1R1, FCGR3B, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764

Hydrocortisone-butyrate

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Hydrocortisone-butyrate

Antigen processing and presentation

5.68E-04

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P30511, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, HLA-F, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-butyrate

Neutrophil extracellular trap formation

1.04E-05

P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, O43315, Q16539

ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805

Hydrocortisone-butyrate

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Hydrocortisone-butyrate

NOD-like receptor signaling pathway

4.89E-04

Q16539, Q14643, P52630, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, Q13546, P29728, P01375, P09341, P12838

MAPK14, ITPR1, STAT2, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, RIPK1, OAS2, TNF, CXCL1, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P12838	DEFA4	Neutrophil defensin 4	-0.754
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P12838	DEFA4	Neutrophil defensin 4	-0.754
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899

Hydrocortisone-butyrate

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Hydrocortisone-butyrate

Cytosolic DNA-sensing pathway

5.86E-05

P01584, P01568, Q13546, Q8NHW4

IL1B, IFNA21, RIPK1, CCL4L2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766

Hydrocortisone-butyrate

C-type lectin receptor signaling pathway

2.17E-02

P52630, P20749, P01375

STAT2, BCL3, TNF

Hydrocortisone-butyrate

Hematopoietic cell lineage

1.10E-02

P13612, P14778, P27930, P15144, P25063, P09693, P01732, P13765, P01375

ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P24723	PRKCH	Protein kinase C eta type	P25063	CD24	Signal transducer CD24	-0.838
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P09564	CD7	T-cell antigen CD7	0.865
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-butyrate

Natural killer cell mediated cytotoxicity

7.46E-04

P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715

TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.835
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P24723	PRKCH	Protein kinase C eta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.822
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P24723	PRKCH	Protein kinase C eta type	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.828
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83

Hydrocortisone-butyrate

IL-17 signaling pathway

1.97E-04

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.708
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.708
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-butyrate

Th1 and Th2 cell differentiation

2.17E-08

Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P24723	PRKCH	Protein kinase C eta type	Q13761	RUNX3	Runt-related transcription factor 3	0.915
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725

Hydrocortisone-butyrate

Th17 cell differentiation

8.69E-06

Q04759, Q16539, P01730, P06239, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, MAPK14, CD4, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877

Hydrocortisone-butyrate

T cell receptor signaling pathway

2.32E-06

P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743

Hydrocortisone-butyrate

B cell receptor signaling pathway

2.80E-03

P49841, P42338, P60033, P07948, P21854, Q8N149

GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P24723	PRKCH	Protein kinase C eta type	P60033	CD81	CD81 antigen	0.711
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P24723	PRKCH	Protein kinase C eta type	P21854	CD72	B-cell differentiation antigen CD72	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
P24723	PRKCH	Protein kinase C eta type	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.765
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764

Hydrocortisone-butyrate

Fc epsilon RI signaling pathway

1.80E-02

Q16539, P42338, P07948, P09917

MAPK14, PIK3CB, LYN, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796

Hydrocortisone-butyrate

TNF signaling pathway

4.74E-02

Q99941, P01584, O95429

CREBL1, IL1B, BAG4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756

Hydrocortisone-butyrate

Circadian entrainment

1.91E-02

P0DP24, Q13557, Q08828, P51828

CALM2, CAMK2D, ADCY1, ADCY7

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815

Hydrocortisone-butyrate

Long-term potentiation

1.91E-02

Q13557, P0DP24, P18848, Q08828

CAMK2D, CALM2, ATF4, ADCY1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75

Hydrocortisone-butyrate

Retrograde endocannabinoid signaling

3.86E-02

P63218, P50151, P48058, Q16539

GNG5, GNG10, GRIA4, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817

Hydrocortisone-butyrate

Glutamatergic synapse

7.09E-03

P48058, P43003, P63218, P50151, P15104

GRIA4, SLC1A3, GNG5, GNG10, GLUL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84

Hydrocortisone-butyrate

Cholinergic synapse

3.77E-02

Q08828, P51828, P18848, Q13557

ADCY1, ADCY7, ATF4, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725

Hydrocortisone-butyrate

Dopaminergic synapse

1.73E-03

P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407, P0DP24, O15516, P48058

GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, CALM2, CLOCK, GRIA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701

Hydrocortisone-butyrate

Inflammatory mediator regulation of TRP channels

7.58E-05

P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, Q14643, Q04759, P0DP24

IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, ITPR1, PRKCQ, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P24723	PRKCH	Protein kinase C eta type	P24723	PRKCH	Protein kinase C eta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone-butyrate

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Hydrocortisone-butyrate

Insulin secretion

2.95E-05

Q08828, P51828, Q99941, P18848, Q13557

ADCY1, ADCY7, CREBL1, ATF4, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone-butyrate

GnRH signaling pathway

6.99E-03

Q08828, P51828, P18848, Q13557, P0DP24

ADCY1, ADCY7, ATF4, CAMK2D, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone-butyrate

Estrogen signaling pathway

4.72E-02

Q99941, P51828, P07900, P11142

CREBL1, ADCY7, HSP90AA1, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Hydrocortisone-butyrate

Melanogenesis

7.61E-03

Q13557, P0DP24, Q08828, P51828

CAMK2D, CALM2, ADCY1, ADCY7

Hydrocortisone-butyrate

Thyroid hormone synthesis

4.47E-03

Q08828, P51828, Q99941, P18848, P02768

ADCY1, ADCY7, CREBL1, ATF4, ALB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718

Hydrocortisone-butyrate

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Hydrocortisone-butyrate

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Hydrocortisone-butyrate

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Hydrocortisone-butyrate

Aldosterone synthesis and secretion

8.00E-06

Q99941, P18848, Q08828, P51828, P0DP24, Q13557, P23634

CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone-butyrate

Cortisol synthesis and secretion

4.16E-03

Q99941, P18848, Q08828, P51828

CREBL1, ATF4, ADCY1, ADCY7

Hydrocortisone-butyrate

Parathyroid hormone synthesis, secretion and action

3.92E-03

Q14643, Q08828, P51828, P22694, P23771, Q99941, P18848, P10415

ITPR1, ADCY1, ADCY7, PRKACB, GATA3, CREBL1, ATF4, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749

Hydrocortisone-butyrate

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Hydrocortisone-butyrate

Non-alcoholic fatty liver disease

3.45E-02

P18848, O75460, P01584, P12074, O15239

ATF4, ERN1, IL1B, COX6A1, NDUFA1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783

Hydrocortisone-butyrate

Cushing syndrome

2.69E-06

Q99941, P18848, Q08828, P51828, O15169, Q13557

CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone-butyrate

Growth hormone synthesis, secretion and action

4.98E-02

Q08828, P51828, Q99941, P18848

ADCY1, ADCY7, CREBL1, ATF4

Hydrocortisone-butyrate

hsa04940

Type I diabetes mellitus

1.58E-02

P30511, P01375

HLA-F, TNF

Hydrocortisone-butyrate

Salivary secretion

3.54E-02

Q08828, P51828, P0DP24

ADCY1, ADCY7, CALM2

Hydrocortisone-butyrate

Gastric acid secretion

2.95E-05

Q08828, P51828, P15311, P0DP24, Q13557

ADCY1, ADCY7, VIL2, CALM2, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone-butyrate

Carbohydrate digestion and absorption

1.57E-02

O43451, P42338

MGAM, PIK3CB

Hydrocortisone-butyrate

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Hydrocortisone-butyrate

Bile secretion

2.44E-02

P22694, P08183

PRKACB, ABCB1

Hydrocortisone-butyrate

Alzheimer disease

2.56E-05

Q92542, O15239, P05496, Q06055, P12074, Q00535, O75460, P0DP24, P01584, P18848, O15169, P05141, P45880, P17861, P28070, P43686, P62195

NCSTN, NDUFA1, ATP5G1, ATP5G2, COX6A1, CDK5, ERN1, CALM2, IL1B, ATF4, AXIN1, SLC25A5, VDAC2, XBP1, PSMB4, PSMC4, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814

Hydrocortisone-butyrate

Parkinson disease

5.28E-04

O15239, P12074, Q06055, P05141, O75460, P18848, P17861, P28070, P43686, P62195, P0DP24, Q13557

NDUFA1, COX6A1, ATP5G2, SLC25A5, ERN1, ATF4, XBP1, PSMB4, PSMC4, PSMC5, CALM2, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725

Hydrocortisone-butyrate

Amyotrophic lateral sclerosis

1.01E-02

Q06055, P17861, P62195

ATP5G2, XBP1, PSMC5

Hydrocortisone-butyrate

Huntington disease

3.54E-02

O15239, P12074, P24928, P62487, P05141, O75460, P28070, P43686

NDUFA1, COX6A1, POLR2A, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723

Hydrocortisone-butyrate

Spinocerebellar ataxia

1.42E-02

P17861, P62195

XBP1, PSMC5

Hydrocortisone-butyrate

Prion disease

1.76E-03

P01584, P46531, P11142, O15239, P05496, P12074, P18848, P05141, P45880, P28070, P43686, Q99941

IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX6A1, ATF4, SLC25A5, VDAC2, PSMB4, PSMC4, CREBL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769

Hydrocortisone-butyrate

Pathways of neurodegeneration - multiple diseases

2.12E-04

O15239, P12074, Q06055, Q8TEV9, O75460, P18848, P17861, P05141, Q00535, O15169, P01584, P0DP24, Q13557, P28070, P43686, P62195

NDUFA1, COX6A1, ATP5G2, SMCR8, ERN1, ATF4, XBP1, SLC25A5, CDK5, AXIN1, IL1B, CALM2, CAMK2D, PSMB4, PSMC4, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814

Hydrocortisone-butyrate

Cocaine addiction

3.54E-02

Q00535, Q99941, P18848

CDK5, CREBL1, ATF4

Hydrocortisone-butyrate

Amphetamine addiction

7.61E-03

P0DP24, Q13557, Q99941, P18848

CALM2, CAMK2D, CREBL1, ATF4

Hydrocortisone-butyrate

Alcoholism

2.05E-05

Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431

HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Hydrocortisone-butyrate

Epithelial cell signaling in Helicobacter pylori infection

2.72E-02

Q16539, P25024, P25025, P07948

MAPK14, CXCR1, CXCR2, LYN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795

Hydrocortisone-butyrate

Salmonella infection

9.85E-03

Q13546, Q13489, O60282, P68371

RIPK1, BIRC3, KIF5C, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
Q05655	PRKCD	Protein kinase C delta type	P84095	RHOG	Rho-related GTP-binding protein RhoG	0.71
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
Q05655	PRKCD	Protein kinase C delta type	P84095	RHOG	Rho-related GTP-binding protein RhoG	0.71
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747

Hydrocortisone-butyrate

Legionellosis

5.53E-03

Q9NR31, P68104

SAR1A, EEF1A1

Hydrocortisone-butyrate

Yersinia infection

1.11E-03

P13612, P06239, Q16539, P01375, P42338, P49841, P01730, P01732

ITGA4, LCK, MAPK14, TNF, PIK3CB, GSK3B, CD4, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77

Hydrocortisone-butyrate

Leishmaniasis

2.69E-02

P13612, O75015, P13765, O60603, P01375, Q16539

ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754

Hydrocortisone-butyrate

Malaria

8.80E-03

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919

Hydrocortisone-butyrate

Amoebiasis

5.94E-04

P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311

CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P24723	PRKCH	Protein kinase C eta type	P05089	ARG1	Arginase-1	-0.749
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P24723	PRKCH	Protein kinase C eta type	P12814	ACTN1	Alpha-actinin-1	-0.869
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P24723	PRKCH	Protein kinase C eta type	P08311	CTSG	Cathepsin G	-0.744
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867

Hydrocortisone-butyrate

hsa05160

Hepatitis C

9.27E-03

P52630, P60033, P49841, P01375

STAT2, CD81, GSK3B, TNF

Hydrocortisone-butyrate

Human cytomegalovirus infection

8.52E-07

P42338, P01375, P63218, P50151, Q14643, P0DP24, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, Q99941, P18848, O00463

PIK3CB, TNF, GNG5, GNG10, ITPR1, CALM2, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896

Hydrocortisone-butyrate

Human papillomavirus infection

1.76E-02

P49841, P24821, P01375, P52630, P30511

GSK3B, TNC, TNF, STAT2, HLA-F

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P17252	PRKCA	Protein kinase C alpha type	Q05086	UBE3A	Ubiquitin-protein ligase E3A	0.703
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P17252	PRKCA	Protein kinase C alpha type	Q05086	UBE3A	Ubiquitin-protein ligase E3A	0.703
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739

Hydrocortisone-butyrate

Epstein-Barr virus infection

2.32E-02

Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, P07766, P20963

HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775

Hydrocortisone-butyrate

Transcriptional misregulation in cancer

4.24E-04

Q12778, Q13315, P14780, P27930, Q15744, Q16548, P11215, O15550, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522

FOXO1, ATM, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, UTX, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863

Hydrocortisone-butyrate

Viral carcinogenesis

2.10E-04

Q12933, P42229, Q13547, Q15283, P58876, P62807, Q16778, O60814

TRAF2, STAT5A, HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Hydrocortisone-butyrate

Chemical carcinogenesis

1.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Hydrocortisone-butyrate

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769

Hydrocortisone-butyrate

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Hydrocortisone-butyrate

PD-L1 expression and PD-1 checkpoint pathway in cancer

5.00E-05

P42338, O95267, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, P01730

PIK3CB, RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84

Hydrocortisone-butyrate

Asthma

5.14E-04

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Hydrocortisone-butyrate

Inflammatory bowel disease

3.54E-06

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832

Hydrocortisone-butyrate

Systemic lupus erythematosus

4.80E-06

P09871, Q93077, P58876, P62807, Q16778, O60814, P68431

C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Hydrocortisone-butyrate

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Hydrocortisone-butyrate

Allograft rejection

2.30E-02

P30511, P01375

HLA-F, TNF

Hydrocortisone-butyrate

Graft-versus-host disease

1.82E-05

P13765, P30511, P10747, P01375, P26715, Q13241

HLA-DOB, HLA-F, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84

Hydrocortisone-butyrate

Diabetic cardiomyopathy

3.59E-02

P11413

G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1

Hydrocortisone-butyrate

hsa05418

Fluid shear stress and atherosclerosis

4.70E-02

Q14145, P10599, P01375

KEAP1, TXN, TNF

Hydrocortisone-cypionate

Pentose phosphate pathway

8.97E-03

P11413

G6PD

Hydrocortisone-cypionate

hsa00190

Oxidative phosphorylation

4.09E-04

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Hydrocortisone-cypionate

Arginine biosynthesis

3.71E-06

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
P60033	CD81	CD81 antigen	P15104	GLUL	Glutamine synthetase	-0.841
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
P60033	CD81	CD81 antigen	P05089	ARG1	Arginase-1	-0.782
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
P60033	CD81	CD81 antigen	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755

Hydrocortisone-cypionate

Alanine, aspartate and glutamate metabolism

2.97E-03

P49448, P15104

GLUD2, GLUL

Hydrocortisone-cypionate

hsa00280

Valine, leucine and isoleucine degradation

1.67E-02

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Hydrocortisone-cypionate

Glutathione metabolism

2.60E-05

Q9UJ14, P11413, Q16772, P09211, P30041

GGTL3, G6PD, GSTA3, GSTP1, PRDX6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75

Hydrocortisone-cypionate

Starch and sucrose metabolism

1.18E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887

Hydrocortisone-cypionate

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Hydrocortisone-cypionate

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

1.91E-02

Q9NY97

B3GNT2

Hydrocortisone-cypionate

hsa00561

Glycerolipid metabolism

2.21E-02

O14494, P06280, P23743

PLPP1, GLA, DGKA

Hydrocortisone-cypionate

hsa00562

Inositol phosphate metabolism

3.69E-02

P27987, P19174, P42338

ITPKB, PLCG1, PIK3CB

Hydrocortisone-cypionate

hsa00600

Sphingolipid metabolism

3.96E-02

Q9BX95, O14494, P06280

SGPP1, PLPP1, GLA

Hydrocortisone-cypionate

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Hydrocortisone-cypionate

Thiamine metabolism

4.32E-02

P05186, P24666

ALPL, ACP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7

Hydrocortisone-cypionate

Nitrogen metabolism

2.97E-03

P15104, P49448

GLUL, GLUD2

Hydrocortisone-cypionate

Aminoacyl-tRNA biosynthesis

1.94E-03

O95363, P14868, Q15046

FARS2, DARS, KARS

Hydrocortisone-cypionate

Metabolism of xenobiotics by cytochrome P450

5.46E-03

Q16772, P09211

GSTA3, GSTP1

Hydrocortisone-cypionate

Drug metabolism - cytochrome P450

1.06E-02

Q16772, P09211

GSTA3, GSTP1

Hydrocortisone-cypionate

Drug metabolism - other enzymes

1.72E-02

Q16772, P09211

GSTA3, GSTP1

Hydrocortisone-cypionate

Metabolic pathways

8.43E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731

Hydrocortisone-cypionate

Carbon metabolism

2.91E-02

P11413

G6PD

Hydrocortisone-cypionate

hsa01210

2-Oxocarboxylic acid metabolism

6.96E-04

P50213

IDH3A

Hydrocortisone-cypionate

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Hydrocortisone-cypionate

RNA transport

9.39E-05

Q15287, Q9UBU9, P35658, P63279, P68104, P55884, O15371, P20042, Q14232

RNPS1, NXF1, NUP214, UBE2I, EEF1A1, EIF3B, EIF3D, EIF2S2, EIF2B1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716

Hydrocortisone-cypionate

Spliceosome

1.81E-06

O43143, O60508, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Hydrocortisone-cypionate

Protein export

9.07E-04

P37108, Q15005

SRP14, SPCS2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726

Hydrocortisone-cypionate

ErbB signaling pathway

3.57E-03

P21860, Q13191, Q13557, P19174, O14944, P42338

ERBB3, CBLB, CAMK2D, PLCG1, EREG, PIK3CB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738

Hydrocortisone-cypionate

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Hydrocortisone-cypionate

hsa04015

Rap1 signaling pathway

1.79E-02

P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174

EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1

Hydrocortisone-cypionate

Calcium signaling pathway

2.19E-05

Q96DU7, Q08828, P45880, Q13557, P21860, P61073, P0DP24, P05141, P51828, P23634

ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, CXCR4, CALM2, SLC25A5, ADCY7, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone-cypionate

cGMP-PKG signaling pathway

2.45E-03

Q99941, P18848, P23634, Q08828, P51828, P05141, P45880, P0DP24

CREBL1, ATF4, ATP2B4, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone-cypionate

hsa04060

Cytokine-cytokine receptor interaction

2.09E-02

P14784, P14778, Q06643, Q13651, Q9HBE5, P09341, P19875, Q93038

IL2RB, IL1R1, LTB, IL10RA, IL21R, CXCL1, CXCL2, TNFRSF25

Hydrocortisone-cypionate

Viral protein interaction with cytokine and cytokine receptor

9.15E-04

Q8NHW4, P09341, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P01375

CCL4L2, CXCL1, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-cypionate

Chemokine signaling pathway

3.82E-05

P25024, P25025, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P49841, Q8WYR1

CXCR1, CXCR2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, GSK3B, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Hydrocortisone-cypionate

NF-kappa B signaling pathway

4.54E-05

P10415, Q13489, P14778, P01584, P29965, P19174, Q04759, Q9UDY8, P06239, Q8WV28, Q13315, P63279, Q8NHW4, P09341, P19875, Q06643, Q9NQC7

BCL2, BIRC3, IL1R1, IL1B, CD40LG, PLCG1, PRKCQ, MALT1, LCK, BLNK, ATM, UBE2I, CCL4L2, CXCL1, CXCL2, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805

Hydrocortisone-cypionate

hsa04070

Phosphatidylinositol signaling system

3.47E-02

P0DP23, Q14643, P23743, P17252

CALM1, ITPR1, DGKA, PRKCA

Hydrocortisone-cypionate

Sphingolipid signaling pathway

4.49E-02

P17252, Q13362, Q9BX95, P10415

PRKCA, PPP2R5C, SGPP1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866

Hydrocortisone-cypionate

hsa04072

Phospholipase D signaling pathway

1.78E-02

P42338, P43657, P25024, P25025, Q14344, Q9GZP0

PIK3CB, P2RY5, CXCR1, CXCR2, GNA13, PDGFD

Hydrocortisone-cypionate

Oocyte meiosis

4.36E-02

Q13557, P0DP24, Q08828, P51828, P27348

CAMK2D, CALM2, ADCY1, ADCY7, YWHAQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751

Hydrocortisone-cypionate

Autophagy - animal

1.76E-03

Q9Y4H2, P42338, Q9NQL2, P22694, Q14643, Q9H1Y0, Q04759

IRS2, PIK3CB, RRAGD, PRKACB, ITPR1, ATG5, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	-0.701
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906

Hydrocortisone-cypionate

Protein processing in endoplasmic reticulum

4.34E-04

P07384, O95487, Q99941, O75460, P17861, P11142, Q9H3Z4, P07900, Q9NR31, O95816

CAPN1, SEC24B, CREBL1, ERN1, XBP1, HSPA8, DNAJC5, HSP90AA1, SAR1A, BAG2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791

Hydrocortisone-cypionate

Phagosome

2.83E-04

P60709, Q15075, Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765

ACTB, EEA1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709

Hydrocortisone-cypionate

mTOR signaling pathway

2.72E-02

P42338, Q9NQL2, Q13322, P49841

PIK3CB, RRAGD, GRB10, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Hydrocortisone-cypionate

hsa04151

PI3K-Akt signaling pathway

5.33E-03

P42338, P43657, P25116, P20827, P49767, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, O60603, P14784, P01568, P10415, P17252, P30281

PIK3CB, P2RY5, F2R, EFNA1, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, BCL2, PRKCA, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1

Hydrocortisone-cypionate

Longevity regulating pathway

4.98E-02

Q08828, P51828, Q99941, P18848

ADCY1, ADCY7, CREBL1, ATF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72

Hydrocortisone-cypionate

Longevity regulating pathway - multiple species

1.56E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Hydrocortisone-cypionate

Necroptosis

1.68E-04

P01568, P23458, Q13489, Q9NQC7, P42224, P05141, P01584, P0C0S5, Q6FI13, P10415, Q13557, Q9H444, O43633, Q08752

IFNA21, JAK1, BIRC3, CYLD, STAT1, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, BCL2, CAMK2D, CHMP4B, CHMP2A, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716

Hydrocortisone-cypionate

Adrenergic signaling in cardiomyocytes

1.49E-04

P09493, Q08828, P51828, Q99941, P18848, Q13362, P0DP23, P0DP24, Q13557, P17252, P10415, P23634

TPM1, ADCY1, ADCY7, CREBL1, ATF4, PPP2R5C, CALM1, CALM2, CAMK2D, PRKCA, BCL2, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone-cypionate

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Hydrocortisone-cypionate

hsa04360

Axon guidance

2.74E-03

P16333, P20827, O95631, P42338, P07332, P23528, P19174, Q06124

NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1, PTPN11

Hydrocortisone-cypionate

hsa04370

VEGF signaling pathway

4.05E-02

P19174, P42338

PLCG1, PIK3CB

Hydrocortisone-cypionate

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Hydrocortisone-cypionate

Osteoclast differentiation

7.71E-05

P09603, Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P42338, P01584, P14778, O75015, P01375, Q8N149, P78324

CSF1, CYLD, GAB2, MAPK14, JAK1, LCK, PIK3CB, IL1B, IL1R1, FCGR3B, TNF, LILRA2, SIRPA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764

Hydrocortisone-cypionate

hsa04390

Hippo signaling pathway

4.35E-02

P63261, O15105

ACTG1, SMAD7

Hydrocortisone-cypionate

Tight junction

2.17E-03

P63261, Q9Y478, Q92974

ACTG1, PRKAB1, ARHGEF2

Hydrocortisone-cypionate

hsa04540

Gap junction

1.29E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Hydrocortisone-cypionate

Antigen processing and presentation

1.77E-03

P13765, P48382, P26715, P26717, Q07444, Q13241, P01732, P30101, P11142, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, PDIA3, HSPA8, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-cypionate

Neutrophil extracellular trap formation

2.29E-03

P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q16778, P68431, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST2H2BE, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805

Hydrocortisone-cypionate

NOD-like receptor signaling pathway

1.85E-02

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P29728, P01375, P09341, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P12838	DEFA4	Neutrophil defensin 4	-0.754
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P12838	DEFA4	Neutrophil defensin 4	-0.754
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899

Hydrocortisone-cypionate

Cytosolic DNA-sensing pathway

1.20E-02

P01584, Q8NHW4

IL1B, CCL4L2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766

Hydrocortisone-cypionate

C-type lectin receptor signaling pathway

3.04E-02

Q9ULY5, P20749, P01375, Q13191, P42338

CLEC4E, BCL3, TNF, CBLB, PIK3CB

Hydrocortisone-cypionate

Hematopoietic cell lineage

5.34E-04

P13612, P14778, P27930, P11215, P15144, P25063, P07766, P09693, P01732, P09564, P13765, P01375

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P24723	PRKCH	Protein kinase C eta type	P25063	CD24	Signal transducer CD24	-0.838
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P09564	CD7	T-cell antigen CD7	0.865
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-cypionate

Natural killer cell mediated cytotoxicity

3.33E-07

P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715

PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.835
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P24723	PRKCH	Protein kinase C eta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.822
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P24723	PRKCH	Protein kinase C eta type	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.828
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83

Hydrocortisone-cypionate

IL-17 signaling pathway

1.42E-02

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.708
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.708
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-cypionate

Th1 and Th2 cell differentiation

1.21E-09

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P24723	PRKCH	Protein kinase C eta type	Q13761	RUNX3	Runt-related transcription factor 3	0.915
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725

Hydrocortisone-cypionate

Th17 cell differentiation

3.81E-09

Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877

Hydrocortisone-cypionate

T cell receptor signaling pathway

5.04E-09

P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743

Hydrocortisone-cypionate

B cell receptor signaling pathway

4.96E-07

P49841, P42338, P60033, P07948, P21854, Q8N149

GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P24723	PRKCH	Protein kinase C eta type	P60033	CD81	CD81 antigen	0.711
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P24723	PRKCH	Protein kinase C eta type	P21854	CD72	B-cell differentiation antigen CD72	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
P24723	PRKCH	Protein kinase C eta type	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.765
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764

Hydrocortisone-cypionate

Fc epsilon RI signaling pathway

5.70E-05

P01375, Q16539, P42338, P07948, P19174, P09917

TNF, MAPK14, PIK3CB, LYN, PLCG1, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796

Hydrocortisone-cypionate

TNF signaling pathway

4.74E-02

Q99941, P01584, O95429

CREBL1, IL1B, BAG4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756

Hydrocortisone-cypionate

hsa04672

Intestinal immune network for IgA production

3.76E-03

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Hydrocortisone-cypionate

Circadian entrainment

1.25E-03

P0DP23, P0DP24, Q13557, P17252, P62873, Q14643, Q08828, P51828

CALM1, CALM2, CAMK2D, PRKCA, GNB1, ITPR1, ADCY1, ADCY7

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815

Hydrocortisone-cypionate

hsa04714

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Hydrocortisone-cypionate

Long-term potentiation

1.63E-03

P17252, Q13557, P0DP23, P0DP24, P18848, Q08828, Q14643

PRKCA, CAMK2D, CALM1, CALM2, ATF4, ADCY1, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75

Hydrocortisone-cypionate

hsa04722

Neurotrophin signaling pathway

9.39E-03

Q05655, P52566

PRKCD, ARHGDIB

Hydrocortisone-cypionate

Retrograde endocannabinoid signaling

1.88E-03

Q14643, P17252, P62873, P63218, P50151, P48058, Q16539, Q16718

ITPR1, PRKCA, GNB1, GNG5, GNG10, GRIA4, MAPK14, NDUFA5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817

Hydrocortisone-cypionate

Glutamatergic synapse

7.09E-03

P48058, P43003, P63218, P50151, P15104

GRIA4, SLC1A3, GNG5, GNG10, GLUL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84

Hydrocortisone-cypionate

Cholinergic synapse

1.75E-03

Q08828, P51828, Q14643, P17252, P62873, P18848, Q13557, P10415

ADCY1, ADCY7, ITPR1, PRKCA, GNB1, ATF4, CAMK2D, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725

Hydrocortisone-cypionate

Dopaminergic synapse

1.89E-04

Q14643, P17252, P62873, P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, P0DP23, P0DP24, O15516, P48058

ITPR1, PRKCA, GNB1, GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, CALM1, CALM2, CLOCK, GRIA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701

Hydrocortisone-cypionate

hsa04744

Phototransduction

1.02E-02

P62873, P0DP23

GNB1, CALM1

Hydrocortisone-cypionate

Inflammatory mediator regulation of TRP channels

6.91E-07

P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24

IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P24723	PRKCH	Protein kinase C eta type	P24723	PRKCH	Protein kinase C eta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone-cypionate

Insulin secretion

2.95E-05

Q08828, P51828, Q99941, P18848, Q13557

ADCY1, ADCY7, CREBL1, ATF4, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone-cypionate

GnRH signaling pathway

5.97E-04

P17252, Q08828, P51828, P18848, Q13557, Q14643, P0DP23, P0DP24

PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, ITPR1, CALM1, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone-cypionate

Estrogen signaling pathway

4.72E-02

Q99941, P51828, P07900, P11142

CREBL1, ADCY7, HSP90AA1, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Hydrocortisone-cypionate

Melanogenesis

7.61E-03

Q13557, P0DP24, Q08828, P51828

CAMK2D, CALM2, ADCY1, ADCY7

Hydrocortisone-cypionate

Thyroid hormone synthesis

4.47E-03

Q08828, P51828, Q99941, P18848, P02768

ADCY1, ADCY7, CREBL1, ATF4, ALB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718

Hydrocortisone-cypionate

hsa04920

Adipocytokine signaling pathway

2.80E-02

Q06124, Q9Y478

PTPN11, PRKAB1

Hydrocortisone-cypionate

Glucagon signaling pathway

3.47E-02

Q12778, Q13370, P0DP23, Q14643

FOXO1, PDE3B, CALM1, ITPR1

Hydrocortisone-cypionate

Renin secretion

8.71E-03

Q14643, Q13370, P0DP23

ITPR1, PDE3B, CALM1

Hydrocortisone-cypionate

Aldosterone synthesis and secretion

8.00E-06

Q99941, P18848, Q08828, P51828, P0DP24, Q13557, P23634

CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone-cypionate

Cortisol synthesis and secretion

4.16E-03

Q99941, P18848, Q08828, P51828

CREBL1, ATF4, ADCY1, ADCY7

Hydrocortisone-cypionate

Parathyroid hormone synthesis, secretion and action

3.77E-02

Q08828, P51828, Q99941, P18848

ADCY1, ADCY7, CREBL1, ATF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749

Hydrocortisone-cypionate

hsa04930

Type II diabetes mellitus

2.68E-02

Q05655

PRKCD

Hydrocortisone-cypionate

Non-alcoholic fatty liver disease

3.45E-02

P18848, O75460, P01584, P12074, O15239

ATF4, ERN1, IL1B, COX6A1, NDUFA1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783

Hydrocortisone-cypionate

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.19E-03

P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174

SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1

Hydrocortisone-cypionate

Cushing syndrome

2.69E-06

Q99941, P18848, Q08828, P51828, O15169, Q13557

CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone-cypionate

Growth hormone synthesis, secretion and action

4.98E-02

Q08828, P51828, Q99941, P18848

ADCY1, ADCY7, CREBL1, ATF4

Hydrocortisone-cypionate

Collecting duct acid secretion

2.86E-02

Q13488, Q9Y666

TCIRG1, SLC12A7

Hydrocortisone-cypionate

Salivary secretion

3.54E-02

Q08828, P51828, P0DP24

ADCY1, ADCY7, CALM2

Hydrocortisone-cypionate

Gastric acid secretion

2.95E-05

Q08828, P51828, P15311, P0DP24, Q13557

ADCY1, ADCY7, VIL2, CALM2, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone-cypionate

Carbohydrate digestion and absorption

2.44E-04

O43451, P42338

MGAM, PIK3CB

Hydrocortisone-cypionate

Alzheimer disease

2.50E-06

Q92542, P01375, O15239, Q16718, O14521, P05496, Q06055, P12074, Q14643, Q00535, Q9NZJ5, O75460, P0DP23, P0DP24, Q13564, P49841, P01584, P18848, Q13509, P68371, O15169, Q92837, P09603, P42338, P05141, P21796, P45880, Q08752, P17861, P28070, P43686, P62195

NCSTN, TNF, NDUFA1, NDUFA5, SDHD, ATP5G1, ATP5G2, COX6A1, ITPR1, CDK5, EIF2AK3, ERN1, CALM1, CALM2, APPBP1, GSK3B, IL1B, ATF4, TUBB3, TUBB2C, AXIN1, FRAT1, CSF1, PIK3CB, SLC25A5, VDAC1, VDAC2, PPID, XBP1, PSMB4, PSMC4, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814

Hydrocortisone-cypionate

Parkinson disease

9.44E-05

O15239, Q16718, O14521, P12074, Q06055, P05141, O75460, P18848, P17861, P28070, P43686, P62195, Q14643, P0DP23, P0DP24, Q13557, Q13509, P68371

NDUFA1, NDUFA5, SDHD, COX6A1, ATP5G2, SLC25A5, ERN1, ATF4, XBP1, PSMB4, PSMC4, PSMC5, ITPR1, CALM1, CALM2, CAMK2D, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725

Hydrocortisone-cypionate

Amyotrophic lateral sclerosis

1.01E-02

Q06055, P17861, P62195

ATP5G2, XBP1, PSMC5

Hydrocortisone-cypionate

Huntington disease

3.54E-02

O15239, P12074, P24928, P62487, P05141, O75460, P28070, P43686

NDUFA1, COX6A1, POLR2A, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723

Hydrocortisone-cypionate

Spinocerebellar ataxia

1.42E-02

P17861, P62195

XBP1, PSMC5

Hydrocortisone-cypionate

Prion disease

9.80E-05

P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P12074, Q14643, P18848, P05141, P45880, P28070, P43686, Q13509, P68371, Q99941, P14598, Q15080

IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX6A1, ITPR1, ATF4, SLC25A5, VDAC2, PSMB4, PSMC4, TUBB3, TUBB2C, CREBL1, NCF1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769

Hydrocortisone-cypionate

Pathways of neurodegeneration - multiple diseases

8.91E-06

Q14643, Q13509, P68371, P10415, O15239, Q16718, O14521, P12074, Q06055, Q8TEV9, O75460, P18848, P17861, Q13561, P05141, P17252, Q00535, O15169, P01584, Q08752, P0DP23, P0DP24, Q13557, P28070, P43686, P62195

ITPR1, TUBB3, TUBB2C, BCL2, NDUFA1, NDUFA5, SDHD, COX6A1, ATP5G2, SMCR8, ERN1, ATF4, XBP1, DCTN2, SLC25A5, PRKCA, CDK5, AXIN1, IL1B, PPID, CALM1, CALM2, CAMK2D, PSMB4, PSMC4, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814

Hydrocortisone-cypionate

Cocaine addiction

3.54E-02

Q00535, Q99941, P18848

CDK5, CREBL1, ATF4

Hydrocortisone-cypionate

Amphetamine addiction

7.61E-03

P0DP24, Q13557, Q99941, P18848

CALM2, CAMK2D, CREBL1, ATF4

Hydrocortisone-cypionate

hsa05110

Vibrio cholerae infection

4.50E-03

Q13488, P17252, P19174, P60709

TCIRG1, PRKCA, PLCG1, ACTB

Hydrocortisone-cypionate

Epithelial cell signaling in Helicobacter pylori infection

3.24E-03

Q16539, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795

Hydrocortisone-cypionate

hsa05130

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Hydrocortisone-cypionate

hsa05131

Shigellosis

3.99E-03

P68431, Q05655, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752, P07737

H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID, PFN1

Hydrocortisone-cypionate

Salmonella infection

6.68E-03

Q9UJU2, P84095, Q13489, P10415, P07737, O60603, Q9BQS8, Q13561, Q13509, P68371

LEF1, RHOG, BIRC3, BCL2, PFN1, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
Q05655	PRKCD	Protein kinase C delta type	P84095	RHOG	Rho-related GTP-binding protein RhoG	0.71
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
Q05655	PRKCD	Protein kinase C delta type	P84095	RHOG	Rho-related GTP-binding protein RhoG	0.71
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747

Hydrocortisone-cypionate

Legionellosis

2.92E-04

Q9NR31, P11215, P68104, P11142, P09341, P19875

SAR1A, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2

Hydrocortisone-cypionate

Yersinia infection

1.92E-05

P13612, P06239, P19174, Q16539, P01375, P42338, P49841, P01730, P01732

ITGA4, LCK, PLCG1, MAPK14, TNF, PIK3CB, GSK3B, CD4, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77

Hydrocortisone-cypionate

Leishmaniasis

3.96E-05

P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, Q15080

ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754

Hydrocortisone-cypionate

Malaria

8.80E-03

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919

Hydrocortisone-cypionate

hsa05145

Toxoplasmosis

1.11E-02

P10415, Q13489, P42224, P13765, O60603, P29965

BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Hydrocortisone-cypionate

Amoebiasis

1.08E-07

P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P24723	PRKCH	Protein kinase C eta type	P05089	ARG1	Arginase-1	-0.749
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P24723	PRKCH	Protein kinase C eta type	P12814	ACTN1	Alpha-actinin-1	-0.869
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P24723	PRKCH	Protein kinase C eta type	P08311	CTSG	Cathepsin G	-0.744
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867

Hydrocortisone-cypionate

hsa05152

Tuberculosis

7.93E-04

Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8

TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1

Hydrocortisone-cypionate

Human cytomegalovirus infection

8.47E-10

P42338, P01375, P30511, P63218, P50151, Q14643, P0DP24, Q14344, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, Q99941, P18848, O00463, P30101

PIK3CB, TNF, HLA-F, GNG5, GNG10, ITPR1, CALM2, GNA13, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TRAF5, PDIA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896

Hydrocortisone-cypionate

Human papillomavirus infection

3.10E-02

P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315

ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P17252	PRKCA	Protein kinase C alpha type	Q05086	UBE3A	Ubiquitin-protein ligase E3A	0.703
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P17252	PRKCA	Protein kinase C alpha type	Q05086	UBE3A	Ubiquitin-protein ligase E3A	0.703
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739

Hydrocortisone-cypionate

hsa05167

Kaposi sarcoma-associated herpesvirus infection

4.73E-02

P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2

IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1

Hydrocortisone-cypionate

Epstein-Barr virus infection

5.97E-04

Q13547, O00463, Q16539, P42338, P07948, P30511, P30101, Q13761, P24522, P01375, P07766, P20963

HDAC1, TRAF5, MAPK14, PIK3CB, LYN, HLA-F, PDIA3, RUNX3, GADD45A, TNF, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775

Hydrocortisone-cypionate

hsa05170

Human immunodeficiency virus 1 infection

3.27E-04

P42338, P30511, P62873, P63218, P50151, P0DP23, P01375, P17252, O00463, P30101, Q14643, P01568, O60603, Q13315, P07766, P20963, P10415, Q9Y6Q5

PIK3CB, HLA-F, GNB1, GNG5, GNG10, CALM1, TNF, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, TLR2, ATM, CD3E, CD247, BCL2, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Hydrocortisone-cypionate

hsa05200

Pathways in cancer

1.55E-03

Q13751, P42338, P08238, P42224, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P49767, Q12778, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784

LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, FOXO1, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733

Hydrocortisone-cypionate

Transcriptional misregulation in cancer

3.51E-02

P14780, P27930, Q15744, Q16548, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522

MMP9, IL1R2, CEBPE, BCL2A1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863

Hydrocortisone-cypionate

Viral carcinogenesis

4.62E-02

Q12933, P42229, Q15283

TRAF2, STAT5A, RASA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Hydrocortisone-cypionate

Chemical carcinogenesis

5.46E-03

Q16772, P09211

GSTA3, GSTP1

Hydrocortisone-cypionate

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769

Hydrocortisone-cypionate

hsa05211

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Hydrocortisone-cypionate

hsa05212

Pancreatic cancer

3.94E-02

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Hydrocortisone-cypionate

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Hydrocortisone-cypionate

hsa05221

Acute myeloid leukemia

4.95E-02

P42338, Q15744, P11215

PIK3CB, CEBPE, ITGAM

Hydrocortisone-cypionate

hsa05223

Non-small cell lung cancer

3.99E-02

P17252, O43524, P19174, O75293

PRKCA, FOXO3, PLCG1, GADD45B

Hydrocortisone-cypionate

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Hydrocortisone-cypionate

hsa05231

Choline metabolism in cancer

3.99E-02

P19174, P23743, O14494, P17252

PLCG1, DGKA, PLPP1, PRKCA

Hydrocortisone-cypionate

PD-L1 expression and PD-1 checkpoint pathway in cancer

5.72E-06

P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84

Hydrocortisone-cypionate

Asthma

1.62E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Hydrocortisone-cypionate

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Hydrocortisone-cypionate

Inflammatory bowel disease

1.09E-03

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832

Hydrocortisone-cypionate

Systemic lupus erythematosus

4.18E-03

P08246, P09871, P10747, P13765, P29965, Q6FI13, P68431

ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Hydrocortisone-cypionate

Rheumatoid arthritis

1.59E-03

Q06643, P13765, Q13488, P10747, P09341, P19875, O60603

LTB, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2

Hydrocortisone-cypionate

Allograft rejection

1.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Hydrocortisone-cypionate

Graft-versus-host disease

1.76E-02

P13765, P01375, P26715, Q13241

HLA-DOB, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84

Hydrocortisone-cypionate

hsa05340

Primary immunodeficiency

4.95E-02

P01732, P07766, P06239

CD8A, CD3E, LCK

Hydrocortisone-cypionate

Diabetic cardiomyopathy

3.66E-03

P17252, P14598, Q15080, Q16718, O14521, P04406, P11413

PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDH, G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1

Hydrocortisone-cypionate

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Hydrocortisone-cypionate

hsa05418

Fluid shear stress and atherosclerosis

3.02E-02

P42338, Q14145, P10599, P01375, P14778, P27930

PIK3CB, KEAP1, TXN, TNF, IL1R1, IL1R2

Hydrocortisone-phosphate

Pentose phosphate pathway

8.97E-03

P11413

G6PD

Hydrocortisone-phosphate

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Hydrocortisone-phosphate

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Hydrocortisone-phosphate

Arginine biosynthesis

1.94E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
P60033	CD81	CD81 antigen	P15104	GLUL	Glutamine synthetase	-0.841
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
P60033	CD81	CD81 antigen	P05089	ARG1	Arginase-1	-0.782
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
P60033	CD81	CD81 antigen	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755

Hydrocortisone-phosphate

Alanine, aspartate and glutamate metabolism

4.32E-02

P49448, P15104

GLUD2, GLUL

Hydrocortisone-phosphate

Glutathione metabolism

1.35E-02

P11413

G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75

Hydrocortisone-phosphate

Starch and sucrose metabolism

7.23E-05

O43451, P46976, P06737

MGAM, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887

Hydrocortisone-phosphate

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Hydrocortisone-phosphate

Thiamine metabolism

6.40E-04

P05186, P24666

ALPL, ACP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7

Hydrocortisone-phosphate

Nitrogen metabolism

4.32E-02

P15104, P49448

GLUL, GLUD2

Hydrocortisone-phosphate

Aminoacyl-tRNA biosynthesis

1.21E-02

P14868

DARS

Hydrocortisone-phosphate

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Hydrocortisone-phosphate

Carbon metabolism

2.91E-02

P11413

G6PD

Hydrocortisone-phosphate

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Hydrocortisone-phosphate

RNA transport

3.11E-02

P68104, Q14232

EEF1A1, EIF2B1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716

Hydrocortisone-phosphate

Viral protein interaction with cytokine and cytokine receptor

2.00E-02

P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P01375

CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-phosphate

Chemokine signaling pathway

3.13E-02

P25024, P25025, P07948, P42338, P63218, P50151, P49407, P49841

CXCR1, CXCR2, LYN, PIK3CB, GNG5, GNG10, ARRB1, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Hydrocortisone-phosphate

NF-kappa B signaling pathway

4.58E-03

Q13489, Q13546, Q9UDY8, Q9UNE0

BIRC3, RIPK1, MALT1, EDAR

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805

Hydrocortisone-phosphate

Sphingolipid signaling pathway

1.94E-02

Q9H228, P01375, Q9UQC2

EDG8, TNF, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866

Hydrocortisone-phosphate

Autophagy - animal

3.61E-02

Q9NQL2, P22694, Q14643, Q9H1Y0, Q04759

RRAGD, PRKACB, ITPR1, ATG5, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	-0.701
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906

Hydrocortisone-phosphate

Protein processing in endoplasmic reticulum

3.89E-02

P17861, Q9NR31

XBP1, SAR1A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791

Hydrocortisone-phosphate

mTOR signaling pathway

2.72E-02

P42338, Q9NQL2, Q13322, P49841

PIK3CB, RRAGD, GRB10, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Hydrocortisone-phosphate

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701

Hydrocortisone-phosphate

Longevity regulating pathway

1.18E-02

Q12778, Q9UEF7, Q96KQ7

FOXO1, KL, EHMT2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72

Hydrocortisone-phosphate

Longevity regulating pathway - multiple species

2.85E-02

Q9Y4H2, Q13547

IRS2, HDAC1

Hydrocortisone-phosphate

Necroptosis

2.93E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716

Hydrocortisone-phosphate

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Hydrocortisone-phosphate

Osteoclast differentiation

4.71E-02

Q16539, P06239, P42338, P14778, O75015, Q8N149

MAPK14, LCK, PIK3CB, IL1R1, FCGR3B, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764

Hydrocortisone-phosphate

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Hydrocortisone-phosphate

Antigen processing and presentation

3.60E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-phosphate

Neutrophil extracellular trap formation

6.66E-04

P11215, O60603, P05164, P08246, Q9UM07, Q13547, P58876, Q16778, O60814, P20160, P08311, O75015, P21730, O43315, Q16539

ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2BC5, HIST2H2BE, H2BC12, AZU1, CTSG, FCGR3B, C5AR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805

Hydrocortisone-phosphate

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Hydrocortisone-phosphate

NOD-like receptor signaling pathway

3.13E-04

Q16539, Q14643, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, Q13546, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838

MAPK14, ITPR1, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P12838	DEFA4	Neutrophil defensin 4	-0.754
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P12838	DEFA4	Neutrophil defensin 4	-0.754
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899

Hydrocortisone-phosphate

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Hydrocortisone-phosphate

Cytosolic DNA-sensing pathway

2.20E-03

P01568, Q13546

IFNA21, RIPK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766

Hydrocortisone-phosphate

Hematopoietic cell lineage

1.10E-02

P13612, P14778, P27930, P15144, P25063, P09693, P01732, P13765, P01375

ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P24723	PRKCH	Protein kinase C eta type	P25063	CD24	Signal transducer CD24	-0.838
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P09564	CD7	T-cell antigen CD7	0.865
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-phosphate

Natural killer cell mediated cytotoxicity

3.11E-04

P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715

TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.835
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P24723	PRKCH	Protein kinase C eta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.822
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P24723	PRKCH	Protein kinase C eta type	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.828
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83

Hydrocortisone-phosphate

IL-17 signaling pathway

1.80E-03

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.708
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.708
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-phosphate

Th1 and Th2 cell differentiation

5.29E-06

Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P24723	PRKCH	Protein kinase C eta type	Q13761	RUNX3	Runt-related transcription factor 3	0.915
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725

Hydrocortisone-phosphate

Th17 cell differentiation

1.31E-04

Q04759, Q16539, P01730, P06239, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, MAPK14, CD4, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877

Hydrocortisone-phosphate

T cell receptor signaling pathway

6.26E-05

P01375, Q04759, P42338, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743

Hydrocortisone-phosphate

B cell receptor signaling pathway

2.80E-03

P49841, P42338, P60033, P07948, P21854, Q8N149

GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P24723	PRKCH	Protein kinase C eta type	P60033	CD81	CD81 antigen	0.711
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P24723	PRKCH	Protein kinase C eta type	P21854	CD72	B-cell differentiation antigen CD72	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
P24723	PRKCH	Protein kinase C eta type	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.765
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764

Hydrocortisone-phosphate

Fc epsilon RI signaling pathway

1.80E-02

Q16539, P42338, P07948, P09917

MAPK14, PIK3CB, LYN, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796

Hydrocortisone-phosphate

Retrograde endocannabinoid signaling

3.86E-02

P63218, P50151, P48058, Q16539

GNG5, GNG10, GRIA4, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817

Hydrocortisone-phosphate

Glutamatergic synapse

7.09E-03

P48058, P43003, P63218, P50151, P15104

GRIA4, SLC1A3, GNG5, GNG10, GLUL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84

Hydrocortisone-phosphate

Dopaminergic synapse

2.35E-02

P63218, P50151, P49841, Q16539, P49407, P48058

GNG5, GNG10, GSK3B, MAPK14, ARRB1, GRIA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701

Hydrocortisone-phosphate

Inflammatory mediator regulation of TRP channels

3.61E-02

P14778, P22694, Q16539, Q14643, Q04759

IL1R1, PRKACB, MAPK14, ITPR1, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P24723	PRKCH	Protein kinase C eta type	P24723	PRKCH	Protein kinase C eta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone-phosphate

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Hydrocortisone-phosphate

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Hydrocortisone-phosphate

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Hydrocortisone-phosphate

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Hydrocortisone-phosphate

Collecting duct acid secretion

4.93E-02

P00918

CA2

Hydrocortisone-phosphate

Carbohydrate digestion and absorption

1.57E-02

O43451, P42338

MGAM, PIK3CB

Hydrocortisone-phosphate

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Hydrocortisone-phosphate

Bile secretion

2.44E-02

P22694, P08183

PRKACB, ABCB1

Hydrocortisone-phosphate

Alzheimer disease

1.01E-02

Q06055, P17861, P62195

ATP5G2, XBP1, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814

Hydrocortisone-phosphate

Parkinson disease

5.41E-03

Q06055, P17861, P62195

ATP5G2, XBP1, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725

Hydrocortisone-phosphate

Amyotrophic lateral sclerosis

1.01E-02

Q06055, P17861, P62195

ATP5G2, XBP1, PSMC5

Hydrocortisone-phosphate

Spinocerebellar ataxia

1.42E-02

P17861, P62195

XBP1, PSMC5

Hydrocortisone-phosphate

Pathways of neurodegeneration - multiple diseases

1.66E-02

Q06055, P17861, P62195

ATP5G2, XBP1, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814

Hydrocortisone-phosphate

Alcoholism

2.10E-03

Q13547, P58876, Q16778, O60814

HDAC1, H2BC5, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Hydrocortisone-phosphate

Epithelial cell signaling in Helicobacter pylori infection

2.72E-02

Q16539, P25024, P25025, P07948

MAPK14, CXCR1, CXCR2, LYN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795

Hydrocortisone-phosphate

Salmonella infection

9.85E-03

Q13546, Q13489, O60282, P68371

RIPK1, BIRC3, KIF5C, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
Q05655	PRKCD	Protein kinase C delta type	P84095	RHOG	Rho-related GTP-binding protein RhoG	0.71
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
Q05655	PRKCD	Protein kinase C delta type	P84095	RHOG	Rho-related GTP-binding protein RhoG	0.71
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747

Hydrocortisone-phosphate

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Hydrocortisone-phosphate

Legionellosis

5.53E-03

Q9NR31, P68104

SAR1A, EEF1A1

Hydrocortisone-phosphate

Yersinia infection

1.11E-03

P13612, P06239, Q16539, P01375, P42338, P49841, P01730, P01732

ITGA4, LCK, MAPK14, TNF, PIK3CB, GSK3B, CD4, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77

Hydrocortisone-phosphate

Leishmaniasis

2.69E-02

P13612, O75015, P13765, O60603, P01375, Q16539

ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754

Hydrocortisone-phosphate

hsa05143

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Hydrocortisone-phosphate

Malaria

9.96E-05

P60033, P69905, P68871, O60603, P01375, P35443, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919

Hydrocortisone-phosphate

Amoebiasis

5.94E-04

P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311

CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P24723	PRKCH	Protein kinase C eta type	P05089	ARG1	Arginase-1	-0.749
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P24723	PRKCH	Protein kinase C eta type	P12814	ACTN1	Alpha-actinin-1	-0.869
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P24723	PRKCH	Protein kinase C eta type	P08311	CTSG	Cathepsin G	-0.744
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867

Hydrocortisone-phosphate

Staphylococcus aureus infection

1.02E-03

P21730, P21462, O75015, P59665, P59666, P12838, P49913

C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774

Hydrocortisone-phosphate

Human cytomegalovirus infection

3.60E-04

P42338, P01375, P63218, P50151, Q14643, P22694, P49841, P14778, Q13651, P25025, Q16539, O00463

PIK3CB, TNF, GNG5, GNG10, ITPR1, PRKACB, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896

Hydrocortisone-phosphate

Epstein-Barr virus infection

2.32E-02

Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, P07766, P20963

HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775

Hydrocortisone-phosphate

Transcriptional misregulation in cancer

4.29E-03

P14780, P27930, Q15744, Q16548, P11215, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522

MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863

Hydrocortisone-phosphate

Viral carcinogenesis

6.44E-03

Q13547, P58876, Q16778, O60814

HDAC1, H2BC5, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Hydrocortisone-phosphate

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Hydrocortisone-phosphate

PD-L1 expression and PD-1 checkpoint pathway in cancer

5.53E-04

P42338, O95267, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730

PIK3CB, RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84

Hydrocortisone-phosphate

Asthma

1.62E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Hydrocortisone-phosphate

Inflammatory bowel disease

1.09E-03

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832

Hydrocortisone-phosphate

Systemic lupus erythematosus

1.18E-02

P58876, Q16778, O60814

H2BC5, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Hydrocortisone-phosphate

Graft-versus-host disease

1.76E-02

P13765, P01375, P26715, Q13241

HLA-DOB, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84

Hydrocortisone-phosphate

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Hydrocortisone-phosphate

Diabetic cardiomyopathy

3.59E-02

P11413

G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1

Hydrocortisone-probutate

Pentose phosphate pathway

8.97E-03

P11413

G6PD

Hydrocortisone-probutate

hsa00071

Fatty acid degradation

3.77E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Hydrocortisone-probutate

hsa00190

Oxidative phosphorylation

8.71E-03

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Hydrocortisone-probutate

Arginine biosynthesis

1.94E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
P60033	CD81	CD81 antigen	P15104	GLUL	Glutamine synthetase	-0.841
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
P60033	CD81	CD81 antigen	P05089	ARG1	Arginase-1	-0.782
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
P60033	CD81	CD81 antigen	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755

Hydrocortisone-probutate

Alanine, aspartate and glutamate metabolism

4.32E-02

P49448, P15104

GLUD2, GLUL

Hydrocortisone-probutate

Glutathione metabolism

2.60E-05

Q9UJ14, P11413, Q16772, P09211, P30041

GGTL3, G6PD, GSTA3, GSTP1, PRDX6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75

Hydrocortisone-probutate

Starch and sucrose metabolism

5.41E-05

O43451, P46976, P06737

MGAM, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887

Hydrocortisone-probutate

Thiamine metabolism

4.32E-02

P05186, P24666

ALPL, ACP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7

Hydrocortisone-probutate

Nitrogen metabolism

4.32E-02

P15104, P49448

GLUL, GLUD2

Hydrocortisone-probutate

Aminoacyl-tRNA biosynthesis

1.92E-04

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Hydrocortisone-probutate

Metabolism of xenobiotics by cytochrome P450

5.46E-03

Q16772, P09211

GSTA3, GSTP1

Hydrocortisone-probutate

Drug metabolism - cytochrome P450

1.06E-02

Q16772, P09211

GSTA3, GSTP1

Hydrocortisone-probutate

Drug metabolism - other enzymes

1.72E-02

Q16772, P09211

GSTA3, GSTP1

Hydrocortisone-probutate

Metabolic pathways

8.43E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731

Hydrocortisone-probutate

Carbon metabolism

2.91E-02

P11413

G6PD

Hydrocortisone-probutate

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P04049

RAF1

Hydrocortisone-probutate

hsa01522

Endocrine resistance

2.16E-02

P04049

RAF1

Hydrocortisone-probutate

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Hydrocortisone-probutate

RNA transport

9.39E-05

Q15287, Q9UBU9, P35658, P63279, P68104, P55884, O15371, P20042, Q14232

RNPS1, NXF1, NUP214, UBE2I, EEF1A1, EIF3B, EIF3D, EIF2S2, EIF2B1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716

Hydrocortisone-probutate

Spliceosome

3.98E-02

Q15427, P38159, P61978, P11142

SF3B4, RBMX, HNRPK, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Hydrocortisone-probutate

Protein export

9.07E-04

P37108, Q15005

SRP14, SPCS2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726

Hydrocortisone-probutate

hsa04010

MAPK signaling pathway

4.15E-02

P04049

RAF1

Hydrocortisone-probutate

ErbB signaling pathway

8.14E-03

P21860, Q13557, O14944, P04049

ERBB3, CAMK2D, EREG, RAF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738

Hydrocortisone-probutate

hsa04014

Ras signaling pathway

3.65E-02

P04049

RAF1

Hydrocortisone-probutate

hsa04015

Rap1 signaling pathway

2.99E-02

P04049

RAF1

Hydrocortisone-probutate

Calcium signaling pathway

2.19E-05

Q96DU7, Q08828, P45880, Q13557, P21860, P61073, P0DP24, P05141, P51828, P23634

ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, CXCR4, CALM2, SLC25A5, ADCY7, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone-probutate

cGMP-PKG signaling pathway

9.49E-04

P04049, Q99941, P18848, P23634, Q08828, P51828, P05141, P45880, P0DP24

RAF1, CREBL1, ATF4, ATP2B4, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone-probutate

hsa04024

cAMP signaling pathway

2.49E-02

P04049

RAF1

Hydrocortisone-probutate

Viral protein interaction with cytokine and cytokine receptor

9.15E-04

Q8NHW4, P09341, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P01375

CCL4L2, CXCL1, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-probutate

Chemokine signaling pathway

1.41E-02

P25024, P25025, P07948, P42338, P63218, P50151, P49407, P04049, P49841

CXCR1, CXCR2, LYN, PIK3CB, GNG5, GNG10, ARRB1, RAF1, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Hydrocortisone-probutate

NF-kappa B signaling pathway

1.25E-04

P10415, Q13489, Q13546, P01584, P29965, Q9UDY8, Q8WV28, Q13315, P63279, Q8NHW4, Q9UNE0, Q9NQC7

BCL2, BIRC3, RIPK1, IL1B, CD40LG, MALT1, BLNK, ATM, UBE2I, CCL4L2, EDAR, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805

Hydrocortisone-probutate

hsa04068

FoxO signaling pathway

1.99E-02

P04049

RAF1

Hydrocortisone-probutate

hsa04070

Phosphatidylinositol signaling system

3.47E-02

P0DP23, Q14643, P23743, P17252

CALM1, ITPR1, DGKA, PRKCA

Hydrocortisone-probutate

Sphingolipid signaling pathway

1.74E-02

P04049, P17252, Q13362, Q9BX95, P10415

RAF1, PRKCA, PPP2R5C, SGPP1, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866

Hydrocortisone-probutate

hsa04072

Phospholipase D signaling pathway

2.82E-02

P04049

RAF1

Hydrocortisone-probutate

hsa04080

Neuroactive ligand-receptor interaction

3.70E-02

P08311, P48058, Q15722, Q9H228, P43657, P21730, P35318

CTSG, GRIA4, LTB4R, EDG8, P2RY5, C5AR1, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
O43451	MGAM	Maltase-glucoamylase	P48058	GRIA4	Glutamate receptor 4	0.746
O43451	MGAM	Maltase-glucoamylase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.738
O43451	MGAM	Maltase-glucoamylase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.807
O43451	MGAM	Maltase-glucoamylase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.815
O43451	MGAM	Maltase-glucoamylase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.926
O43451	MGAM	Maltase-glucoamylase	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.883

Hydrocortisone-probutate

Oocyte meiosis

4.36E-02

Q13557, P0DP24, Q08828, P51828, P27348

CAMK2D, CALM2, ADCY1, ADCY7, YWHAQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751

Hydrocortisone-probutate

Autophagy - animal

5.15E-02

P04049, Q9NQL2, P22694, Q14643, Q9H1Y0, Q04759

RAF1, RRAGD, PRKACB, ITPR1, ATG5, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	-0.701
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906

Hydrocortisone-probutate

Protein processing in endoplasmic reticulum

5.75E-03

Q99941, O75460, P17861, P11142, Q9H3Z4, P07900, Q9NR31

CREBL1, ERN1, XBP1, HSPA8, DNAJC5, HSP90AA1, SAR1A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791

Hydrocortisone-probutate

Phagosome

1.59E-03

Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709

Hydrocortisone-probutate

mTOR signaling pathway

2.47E-02

P42338, P04049, Q9NQL2, Q13322, P49841

PIK3CB, RAF1, RRAGD, GRB10, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Hydrocortisone-probutate

hsa04151

PI3K-Akt signaling pathway

4.50E-02

P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252

F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1

Hydrocortisone-probutate

Apoptosis

2.16E-02

P04049

RAF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701

Hydrocortisone-probutate

Longevity regulating pathway

3.41E-03

Q12778, Q08828, P51828, Q99941, P18848, Q9UEF7, Q96KQ7

FOXO1, ADCY1, ADCY7, CREBL1, ATF4, KL, EHMT2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72

Hydrocortisone-probutate

Necroptosis

2.08E-05

P01568, P23458, Q13489, Q9NQC7, Q13546, P42224, P05141, P01584, P0C0S5, Q6FI13, P10415, Q13557, Q9H444, O43633, Q08752

IFNA21, JAK1, BIRC3, CYLD, RIPK1, STAT1, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, BCL2, CAMK2D, CHMP4B, CHMP2A, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716

Hydrocortisone-probutate

hsa04218

Cellular senescence

2.49E-02

P04049

RAF1

Hydrocortisone-probutate

Adrenergic signaling in cardiomyocytes

1.49E-04

P09493, Q08828, P51828, Q99941, P18848, Q13362, P0DP23, P0DP24, Q13557, P17252, P10415, P23634

TPM1, ADCY1, ADCY7, CREBL1, ATF4, PPP2R5C, CALM1, CALM2, CAMK2D, PRKCA, BCL2, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone-probutate

hsa04270

Vascular smooth muscle contraction

2.32E-02

P04049

RAF1

Hydrocortisone-probutate

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Hydrocortisone-probutate

hsa04360

Axon guidance

2.49E-02

P04049

RAF1

Hydrocortisone-probutate

hsa04370

VEGF signaling pathway

8.29E-03

P04049

RAF1

Hydrocortisone-probutate

hsa04371

Apelin signaling pathway

2.65E-02

P04049

RAF1

Hydrocortisone-probutate

Osteoclast differentiation

6.08E-03

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P42338, P01584, P14778, O75015, Q8N149

CYLD, GAB2, MAPK14, JAK1, LCK, PIK3CB, IL1B, IL1R1, FCGR3B, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764

Hydrocortisone-probutate

hsa04510

Focal adhesion

3.48E-02

P04049

RAF1

Hydrocortisone-probutate

hsa04540

Gap junction

2.79E-03

P17252, Q13509, P68371, P04049, Q14643

PRKCA, TUBB3, TUBB2C, RAF1, ITPR1

Hydrocortisone-probutate

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P04049

RAF1

Hydrocortisone-probutate

Antigen processing and presentation

3.60E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-probutate

Neutrophil extracellular trap formation

1.74E-04

P17252, P04049, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, Q16778, P68431, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

PRKCA, RAF1, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST2H2BE, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805

Hydrocortisone-probutate

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Hydrocortisone-probutate

NOD-like receptor signaling pathway

3.13E-04

Q16539, Q14643, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, Q13546, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838

MAPK14, ITPR1, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P12838	DEFA4	Neutrophil defensin 4	-0.754
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P12838	DEFA4	Neutrophil defensin 4	-0.754
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899

Hydrocortisone-probutate

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Hydrocortisone-probutate

Cytosolic DNA-sensing pathway

5.86E-05

P01584, P01568, Q13546, Q8NHW4

IL1B, IFNA21, RIPK1, CCL4L2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766

Hydrocortisone-probutate

C-type lectin receptor signaling pathway

1.49E-02

P04049

RAF1

Hydrocortisone-probutate

hsa04630

JAK-STAT signaling pathway

1.49E-02

P04049

RAF1

Hydrocortisone-probutate

Hematopoietic cell lineage

3.92E-04

P13612, P14778, P27930, P15144, P25063, P07766, P09693, P01732, P01730, P13765, P01375

ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P24723	PRKCH	Protein kinase C eta type	P25063	CD24	Signal transducer CD24	-0.838
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P09564	CD7	T-cell antigen CD7	0.865
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-probutate

Natural killer cell mediated cytotoxicity

2.28E-07

P01375, P78314, P06239, O60880, P20963, P04049, Q13241, P26718, O75015, P26717, P26715

TNF, SH3BP2, LCK, SH2D1A, CD247, RAF1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.835
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P24723	PRKCH	Protein kinase C eta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.822
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P24723	PRKCH	Protein kinase C eta type	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.828
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83

Hydrocortisone-probutate

IL-17 signaling pathway

1.42E-02

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.708
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.708
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-probutate

Th1 and Th2 cell differentiation

2.79E-09

Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P24723	PRKCH	Protein kinase C eta type	Q13761	RUNX3	Runt-related transcription factor 3	0.915
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725

Hydrocortisone-probutate

Th17 cell differentiation

1.17E-07

Q04759, Q16539, P01730, P06239, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, MAPK14, CD4, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877

Hydrocortisone-probutate

T cell receptor signaling pathway

7.66E-09

P01375, Q04759, P42338, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743

Hydrocortisone-probutate

B cell receptor signaling pathway

1.99E-04

P49841, P42338, P60033, P07948, P21854, Q8N149, P04049

GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2, RAF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P24723	PRKCH	Protein kinase C eta type	P60033	CD81	CD81 antigen	0.711
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P24723	PRKCH	Protein kinase C eta type	P21854	CD72	B-cell differentiation antigen CD72	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
P24723	PRKCH	Protein kinase C eta type	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.765
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764

Hydrocortisone-probutate

Fc epsilon RI signaling pathway

4.03E-03

Q16539, P42338, P07948, P04049, P09917

MAPK14, PIK3CB, LYN, RAF1, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796

Hydrocortisone-probutate

hsa04666

Fc gamma R-mediated phagocytosis

2.32E-02

P04049

RAF1

Hydrocortisone-probutate

TNF signaling pathway

4.74E-02

Q99941, P01584, O95429

CREBL1, IL1B, BAG4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756

Hydrocortisone-probutate

hsa04672

Intestinal immune network for IgA production

3.76E-03

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Hydrocortisone-probutate

Circadian entrainment

1.25E-03

P0DP23, P0DP24, Q13557, P17252, P62873, Q14643, Q08828, P51828

CALM1, CALM2, CAMK2D, PRKCA, GNB1, ITPR1, ADCY1, ADCY7

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815

Hydrocortisone-probutate

Long-term potentiation

7.87E-04

P17252, Q13557, P0DP23, P0DP24, P18848, Q08828, P04049, Q14643

PRKCA, CAMK2D, CALM1, CALM2, ATF4, ADCY1, RAF1, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75

Hydrocortisone-probutate

hsa04722

Neurotrophin signaling pathway

4.44E-04

Q05655, P04049, P52566

PRKCD, RAF1, ARHGDIB

Hydrocortisone-probutate

Retrograde endocannabinoid signaling

1.88E-03

Q14643, P17252, P62873, P63218, P50151, P48058, Q16539, Q16718

ITPR1, PRKCA, GNB1, GNG5, GNG10, GRIA4, MAPK14, NDUFA5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817

Hydrocortisone-probutate

Glutamatergic synapse

7.09E-03

P48058, P43003, P63218, P50151, P15104

GRIA4, SLC1A3, GNG5, GNG10, GLUL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84

Hydrocortisone-probutate

Cholinergic synapse

1.75E-03

Q08828, P51828, Q14643, P17252, P62873, P18848, Q13557, P10415

ADCY1, ADCY7, ITPR1, PRKCA, GNB1, ATF4, CAMK2D, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725

Hydrocortisone-probutate

hsa04726

Serotonergic synapse

1.33E-02

P04049

RAF1

Hydrocortisone-probutate

Dopaminergic synapse

1.89E-04

Q14643, P17252, P62873, P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, P0DP23, P0DP24, O15516, P48058

ITPR1, PRKCA, GNB1, GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, CALM1, CALM2, CLOCK, GRIA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701

Hydrocortisone-probutate

hsa04730

Long-term depression

1.16E-02

P04049

RAF1

Hydrocortisone-probutate

hsa04744

Phototransduction

1.02E-02

P62873, P0DP23

GNB1, CALM1

Hydrocortisone-probutate

Inflammatory mediator regulation of TRP channels

7.58E-05

P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, Q14643, Q04759, P0DP24

IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, ITPR1, PRKCQ, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P24723	PRKCH	Protein kinase C eta type	P24723	PRKCH	Protein kinase C eta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone-probutate

hsa04810

Regulation of actin cytoskeleton

3.81E-02

P04049

RAF1

Hydrocortisone-probutate

Insulin signaling pathway

1.49E-02

P04049

RAF1

Hydrocortisone-probutate

Insulin secretion

2.95E-05

Q08828, P51828, Q99941, P18848, Q13557

ADCY1, ADCY7, CREBL1, ATF4, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone-probutate

GnRH signaling pathway

3.21E-04

P17252, Q08828, P51828, P18848, Q13557, Q14643, P0DP23, P0DP24, P04049

PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, ITPR1, CALM1, CALM2, RAF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone-probutate

hsa04914

Progesterone-mediated oocyte maturation

2.16E-02

P04049

RAF1

Hydrocortisone-probutate

Estrogen signaling pathway

1.26E-02

P04049, Q99941, P51828, P07900, P11142

RAF1, CREBL1, ADCY7, HSP90AA1, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Hydrocortisone-probutate

Melanogenesis

1.80E-03

Q13557, P0DP24, Q08828, P51828, P04049

CAMK2D, CALM2, ADCY1, ADCY7, RAF1

Hydrocortisone-probutate

hsa04917

Prolactin signaling pathway

6.63E-03

P04049

RAF1

Hydrocortisone-probutate

Thyroid hormone synthesis

4.47E-03

Q08828, P51828, Q99941, P18848, P02768

ADCY1, ADCY7, CREBL1, ATF4, ALB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718

Hydrocortisone-probutate

Thyroid hormone signaling pathway

1.82E-02

P04049

RAF1

Hydrocortisone-probutate

hsa04921

Oxytocin signaling pathway

2.32E-02

P04049

RAF1

Hydrocortisone-probutate

Glucagon signaling pathway

3.47E-02

Q12778, Q13370, P0DP23, Q14643

FOXO1, PDE3B, CALM1, ITPR1

Hydrocortisone-probutate

Renin secretion

8.71E-03

Q14643, Q13370, P0DP23

ITPR1, PDE3B, CALM1

Hydrocortisone-probutate

Aldosterone synthesis and secretion

8.00E-06

Q99941, P18848, Q08828, P51828, P0DP24, Q13557, P23634

CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone-probutate

hsa04926

Relaxin signaling pathway

2.32E-02

P04049

RAF1

Hydrocortisone-probutate

Cortisol synthesis and secretion

4.16E-03

Q99941, P18848, Q08828, P51828

CREBL1, ATF4, ADCY1, ADCY7

Hydrocortisone-probutate

Parathyroid hormone synthesis, secretion and action

1.20E-02

Q08828, P51828, P04049, Q99941, P18848

ADCY1, ADCY7, RAF1, CREBL1, ATF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749

Hydrocortisone-probutate

hsa04929

GnRH secretion

4.98E-03

P04049

RAF1

Hydrocortisone-probutate

hsa04930

Type II diabetes mellitus

2.68E-02

Q05655

PRKCD

Hydrocortisone-probutate

Non-alcoholic fatty liver disease

3.45E-02

P18848, O75460, P01584, P12074, O15239

ATF4, ERN1, IL1B, COX6A1, NDUFA1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783

Hydrocortisone-probutate

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.27E-02

P42224, P10415, Q12778, P49767, P17252

STAT1, BCL2, FOXO1, VEGFC, PRKCA

Hydrocortisone-probutate

Cushing syndrome

2.69E-06

Q99941, P18848, Q08828, P51828, O15169, Q13557

CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone-probutate

Growth hormone synthesis, secretion and action

1.68E-02

Q08828, P51828, P04049, Q99941, P18848

ADCY1, ADCY7, RAF1, CREBL1, ATF4

Hydrocortisone-probutate

Collecting duct acid secretion

2.86E-02

Q13488, Q9Y666

TCIRG1, SLC12A7

Hydrocortisone-probutate

Salivary secretion

3.54E-02

Q08828, P51828, P0DP24

ADCY1, ADCY7, CALM2

Hydrocortisone-probutate

Gastric acid secretion

2.95E-05

Q08828, P51828, P15311, P0DP24, Q13557

ADCY1, ADCY7, VIL2, CALM2, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone-probutate

Carbohydrate digestion and absorption

1.57E-02

O43451, P42338

MGAM, PIK3CB

Hydrocortisone-probutate

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Hydrocortisone-probutate

Alzheimer disease

7.87E-06

Q92542, O15239, Q16718, O14521, P05496, Q06055, P12074, Q14643, Q00535, O75460, P0DP23, P0DP24, P01584, P18848, Q13509, P68371, O15169, P05141, P45880, Q08752, P17861, P28070, P43686, P62195

NCSTN, NDUFA1, NDUFA5, SDHD, ATP5G1, ATP5G2, COX6A1, ITPR1, CDK5, ERN1, CALM1, CALM2, IL1B, ATF4, TUBB3, TUBB2C, AXIN1, SLC25A5, VDAC2, PPID, XBP1, PSMB4, PSMC4, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814

Hydrocortisone-probutate

Parkinson disease

9.44E-05

O15239, Q16718, O14521, P12074, Q06055, P05141, O75460, P18848, P17861, P28070, P43686, P62195, Q14643, P0DP23, P0DP24, Q13557, Q13509, P68371

NDUFA1, NDUFA5, SDHD, COX6A1, ATP5G2, SLC25A5, ERN1, ATF4, XBP1, PSMB4, PSMC4, PSMC5, ITPR1, CALM1, CALM2, CAMK2D, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725

Hydrocortisone-probutate

Amyotrophic lateral sclerosis

1.01E-02

Q06055, P17861, P62195

ATP5G2, XBP1, PSMC5

Hydrocortisone-probutate

Huntington disease

3.54E-02

O15239, P12074, P24928, P62487, P05141, O75460, P28070, P43686

NDUFA1, COX6A1, POLR2A, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723

Hydrocortisone-probutate

Spinocerebellar ataxia

1.42E-02

P17861, P62195

XBP1, PSMC5

Hydrocortisone-probutate

Prion disease

9.80E-05

P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P12074, Q14643, P18848, P05141, P45880, P28070, P43686, Q13509, P68371, Q99941, P14598, Q15080

IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX6A1, ITPR1, ATF4, SLC25A5, VDAC2, PSMB4, PSMC4, TUBB3, TUBB2C, CREBL1, NCF1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769

Hydrocortisone-probutate

Pathways of neurodegeneration - multiple diseases

8.91E-06

ITPR1, TUBB3, TUBB2C, BCL2, NDUFA1, NDUFA5, SDHD, COX6A1, ATP5G2, SMCR8, ERN1, ATF4, XBP1, DCTN2, SLC25A5, PRKCA, CDK5, AXIN1, IL1B, PPID, CALM1, CALM2, CAMK2D, PSMB4, PSMC4, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814

Hydrocortisone-probutate

Cocaine addiction

3.54E-02

Q00535, Q99941, P18848

CDK5, CREBL1, ATF4

Hydrocortisone-probutate

Amphetamine addiction

7.61E-03

P0DP24, Q13557, Q99941, P18848

CALM2, CAMK2D, CREBL1, ATF4

Hydrocortisone-probutate

Alcoholism

2.49E-02

P04049

RAF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Hydrocortisone-probutate

Epithelial cell signaling in Helicobacter pylori infection

2.47E-03

Q16539, P09341, P25024, P25025, P07948

MAPK14, CXCL1, CXCR1, CXCR2, LYN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795

Hydrocortisone-probutate

hsa05131

Shigellosis

3.99E-03

P68431, Q05655, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752, P07737

H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID, PFN1

Hydrocortisone-probutate

Salmonella infection

1.08E-04

P04049, Q9UJU2, P84095, Q13546, Q13489, P10415, P07737, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371

RAF1, LEF1, RHOG, RIPK1, BIRC3, BCL2, PFN1, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
Q05655	PRKCD	Protein kinase C delta type	P84095	RHOG	Rho-related GTP-binding protein RhoG	0.71
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
Q05655	PRKCD	Protein kinase C delta type	P84095	RHOG	Rho-related GTP-binding protein RhoG	0.71
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747

Hydrocortisone-probutate

Legionellosis

5.53E-03

Q9NR31, P68104

SAR1A, EEF1A1

Hydrocortisone-probutate

Yersinia infection

5.36E-05

P13612, P06239, Q16539, P01375, P42338, P49841, P01730, P01732

ITGA4, LCK, MAPK14, TNF, PIK3CB, GSK3B, CD4, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77

Hydrocortisone-probutate

Leishmaniasis

2.45E-04

P13612, O75015, P14598, P42224, P13765, O60603, P01375, P29350, Q16539, Q15080

ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, TNF, PTPN6, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754

Hydrocortisone-probutate

Malaria

6.84E-04

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919

Hydrocortisone-probutate

hsa05145

Toxoplasmosis

1.11E-02

P10415, Q13489, P42224, P13765, O60603, P29965

BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Hydrocortisone-probutate

Amoebiasis

4.74E-05

P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311

CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P24723	PRKCH	Protein kinase C eta type	P05089	ARG1	Arginase-1	-0.749
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P24723	PRKCH	Protein kinase C eta type	P12814	ACTN1	Alpha-actinin-1	-0.869
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P24723	PRKCH	Protein kinase C eta type	P08311	CTSG	Cathepsin G	-0.744
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867

Hydrocortisone-probutate

Staphylococcus aureus infection

1.02E-03

P21730, P21462, O75015, P59665, P59666, P12838, P49913

C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774

Hydrocortisone-probutate

hsa05152

Tuberculosis

9.31E-04

P04049, Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8

RAF1, TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1

Hydrocortisone-probutate

hsa05160

Hepatitis C

1.99E-02

P04049

RAF1

Hydrocortisone-probutate

hsa05161

Hepatitis B

1.99E-02

P04049

RAF1

Hydrocortisone-probutate

Human cytomegalovirus infection

2.07E-06

P42338, P04049, P01375, P63218, P50151, Q14643, P0DP24, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, Q99941, P18848, O00463

PIK3CB, RAF1, TNF, GNG5, GNG10, ITPR1, CALM2, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896

Hydrocortisone-probutate

hsa05164

Influenza A

3.65E-02

P04049

RAF1

Hydrocortisone-probutate

Human papillomavirus infection

3.10E-02

P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315

ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P24821	TNC	Tenascin	-0.733
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P17252	PRKCA	Protein kinase C alpha type	Q05086	UBE3A	Ubiquitin-protein ligase E3A	0.703
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P16144	ITGB4	Integrin beta-4	0.755
P17252	PRKCA	Protein kinase C alpha type	Q05086	UBE3A	Ubiquitin-protein ligase E3A	0.703
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.779
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739

Hydrocortisone-probutate

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.48E-02

P01568, P42224, P62873, Q14643, P04049, P0DP23, Q9UJU2

IFNA21, STAT1, GNB1, ITPR1, RAF1, CALM1, LEF1

Hydrocortisone-probutate

Epstein-Barr virus infection

2.32E-02

Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, P07766, P20963

HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775

Hydrocortisone-probutate

hsa05170

Human immunodeficiency virus 1 infection

8.78E-04

P04049, P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5

RAF1, GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Hydrocortisone-probutate

hsa05200

Pathways in cancer

4.99E-02

P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568

STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733

Hydrocortisone-probutate

Transcriptional misregulation in cancer

3.51E-02

P14780, P27930, Q15744, Q16548, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522

MMP9, IL1R2, CEBPE, BCL2A1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863

Hydrocortisone-probutate

Viral carcinogenesis

4.62E-02

Q12933, P42229, Q15283

TRAF2, STAT5A, RASA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Hydrocortisone-probutate

Chemical carcinogenesis

5.46E-03

Q16772, P09211

GSTA3, GSTP1

Hydrocortisone-probutate

hsa05205

Proteoglycans in cancer

3.48E-02

P04049

RAF1

Hydrocortisone-probutate

MicroRNAs in cancer

6.19E-04

P15311, P21860, P61978, P46531, P63279, P22105, P04049

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RAF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769

Hydrocortisone-probutate

hsa05210

Colorectal cancer

1.66E-02

P04049

RAF1

Hydrocortisone-probutate

hsa05211

Renal cell carcinoma

1.16E-02

P04049

RAF1

Hydrocortisone-probutate

hsa05212

Pancreatic cancer

1.16E-02

P04049

RAF1

Hydrocortisone-probutate

hsa05213

Endometrial cancer

9.95E-03

P04049

RAF1

Hydrocortisone-probutate

hsa05214

Glioma

9.95E-03

P04049

RAF1

Hydrocortisone-probutate

hsa05215

Prostate cancer

1.33E-02

P04049

RAF1

Hydrocortisone-probutate

hsa05218

Melanoma

6.63E-03

P04049

RAF1

Hydrocortisone-probutate

hsa05219

Bladder cancer

4.98E-03

P04049

RAF1

Hydrocortisone-probutate

hsa05220

Chronic myeloid leukemia

9.95E-03

P04049

RAF1

Hydrocortisone-probutate

hsa05221

Acute myeloid leukemia

8.29E-03

P04049

RAF1

Hydrocortisone-probutate

hsa05223

Non-small cell lung cancer

6.63E-03

P04049

RAF1

Hydrocortisone-probutate

hsa05224

Breast cancer

1.49E-02

P04049

RAF1

Hydrocortisone-probutate

hsa05225

Hepatocellular carcinoma

1.33E-02

P04049

RAF1

Hydrocortisone-probutate

hsa05226

Gastric cancer

8.29E-03

P04049

RAF1

Hydrocortisone-probutate

Central carbon metabolism in cancer

1.00E-04

P04049, P11413

RAF1, G6PD

Hydrocortisone-probutate

hsa05231

Choline metabolism in cancer

1.33E-02

P04049

RAF1

Hydrocortisone-probutate

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.65E-06

P42338, O95267, P07766, P20963, P09693, P06239, P04049, O60603, Q04759, Q16539, P01730

PIK3CB, RASGRP1, CD3E, CD247, CD3G, LCK, RAF1, TLR2, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84

Hydrocortisone-probutate

Asthma

1.62E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Hydrocortisone-probutate

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Hydrocortisone-probutate

Inflammatory bowel disease

1.09E-03

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832

Hydrocortisone-probutate

Systemic lupus erythematosus

4.18E-03

P08246, P09871, P10747, P13765, P29965, Q6FI13, P68431

ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Hydrocortisone-probutate

Rheumatoid arthritis

1.29E-02

P13765, Q13488, P10747, O60603

HLA-DOB, TCIRG1, CD28, TLR2

Hydrocortisone-probutate

Allograft rejection

1.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Hydrocortisone-probutate

Graft-versus-host disease

1.76E-02

P13765, P01375, P26715, Q13241

HLA-DOB, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84

Hydrocortisone-probutate

hsa05340

Primary immunodeficiency

3.76E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Hydrocortisone-probutate

Diabetic cardiomyopathy

2.33E-02

P17252, P14598, Q15080, Q16718, O14521, P11413

PRKCA, NCF1, NCF4, NDUFA5, SDHD, G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1

Hydrocortisone-probutate

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Hydrocortisone

Pentose phosphate pathway

8.97E-03

P11413

G6PD

Hydrocortisone

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Hydrocortisone

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Hydrocortisone

Glutathione metabolism

1.35E-02

P11413

G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75

Hydrocortisone

Starch and sucrose metabolism

2.00E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887

Hydrocortisone

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Hydrocortisone

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Hydrocortisone

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Hydrocortisone

Thiamine metabolism

5.29E-03

P05186, P24666

ALPL, ACP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7

Hydrocortisone

Aminoacyl-tRNA biosynthesis

1.21E-02

P14868

DARS

Hydrocortisone

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Hydrocortisone

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Hydrocortisone

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Hydrocortisone

Carbon metabolism

2.91E-02

P11413

G6PD

Hydrocortisone

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Hydrocortisone

RNA transport

9.39E-05

Q15287, Q9UBU9, P35658, P63279, P68104, P55884, O15371, P20042, Q14232

RNPS1, NXF1, NUP214, UBE2I, EEF1A1, EIF3B, EIF3D, EIF2S2, EIF2B1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716

Hydrocortisone

Spliceosome

3.98E-02

Q15427, P38159, P61978, P11142

SF3B4, RBMX, HNRPK, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Hydrocortisone

Protein export

1.43E-02

P37108, Q15005

SRP14, SPCS2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726

Hydrocortisone

ErbB signaling pathway

3.74E-02

P21860, Q13557, O14944

ERBB3, CAMK2D, EREG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738

Hydrocortisone

Calcium signaling pathway

6.50E-04

Q96DU7, P45880, Q13557, P21860, P51828, P23634

ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone

cGMP-PKG signaling pathway

4.72E-02

Q99941, P23634, P51828, P45880

CREBL1, ATP2B4, ADCY7, VDAC2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone

Viral protein interaction with cytokine and cytokine receptor

2.00E-02

P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P01375

CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone

NF-kappa B signaling pathway

4.58E-03

Q13489, Q13546, Q9UDY8, Q9UNE0

BIRC3, RIPK1, MALT1, EDAR

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805

Hydrocortisone

Sphingolipid signaling pathway

1.94E-02

Q9H228, P01375, Q9UQC2

EDG8, TNF, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.816
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866

Hydrocortisone

Oocyte meiosis

1.33E-02

P51812, Q02750, P16298, Q17RY0

RPS6KA3, MAP2K1, PPP3CB, CPEB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751

Hydrocortisone

Autophagy - animal

3.61E-02

Q9NQL2, P22694, Q14643, Q9H1Y0, Q04759

RRAGD, PRKACB, ITPR1, ATG5, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	-0.701
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906

Hydrocortisone

Protein processing in endoplasmic reticulum

5.75E-03

Q99941, O75460, P17861, P11142, Q9H3Z4, P07900, Q9NR31

CREBL1, ERN1, XBP1, HSPA8, DNAJC5, HSP90AA1, SAR1A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791

Hydrocortisone

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Hydrocortisone

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P08183	ABCB1	ATP-dependent translocase ABCB1	O76075	DFFB	DNA fragmentation factor subunit beta	0.754
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9NR28	DIABLO	Diablo IAP-binding mitochondrial protein	0.765
P08183	ABCB1	ATP-dependent translocase ABCB1	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701

Hydrocortisone

Longevity regulating pathway

1.18E-02

Q12778, Q9UEF7, Q96KQ7

FOXO1, KL, EHMT2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72

Hydrocortisone

Longevity regulating pathway - multiple species

2.85E-02

Q9Y4H2, Q13547

IRS2, HDAC1

Hydrocortisone

Necroptosis

2.93E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716

Hydrocortisone

Adrenergic signaling in cardiomyocytes

3.98E-02

P51828, Q99941, Q13557, P23634

ADCY7, CREBL1, CAMK2D, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Hydrocortisone

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Hydrocortisone

hsa04370

VEGF signaling pathway

2.68E-03

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Hydrocortisone

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Hydrocortisone

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Hydrocortisone

Antigen processing and presentation

3.60E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone

Neutrophil extracellular trap formation

4.90E-05

P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431, P20160, P08311, O75015, P21730, O43315, Q16539

ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AZU1, CTSG, FCGR3B, C5AR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805

Hydrocortisone

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Hydrocortisone

NOD-like receptor signaling pathway

3.13E-04

Q16539, Q14643, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, Q13546, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838

MAPK14, ITPR1, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P12838	DEFA4	Neutrophil defensin 4	-0.754
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P12838	DEFA4	Neutrophil defensin 4	-0.754
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899

Hydrocortisone

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Hydrocortisone

Cytosolic DNA-sensing pathway

2.20E-03

P01568, Q13546

IFNA21, RIPK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766

Hydrocortisone

Hematopoietic cell lineage

1.10E-02

P13612, P14778, P27930, P15144, P25063, P09693, P01732, P13765, P01375

ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P24723	PRKCH	Protein kinase C eta type	P25063	CD24	Signal transducer CD24	-0.838
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P09564	CD7	T-cell antigen CD7	0.865
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone

Natural killer cell mediated cytotoxicity

1.69E-05

P16298, P50591, P01375, P06239, O60880, P20963, Q02750, Q13241, P26718, O75015, P26717, P26715

PPP3CB, TNFSF10, TNF, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.835
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P24723	PRKCH	Protein kinase C eta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.822
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P24723	PRKCH	Protein kinase C eta type	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.828
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83

Hydrocortisone

IL-17 signaling pathway

1.80E-03

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.708
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.708
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone

Th1 and Th2 cell differentiation

5.94E-04

Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765

PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P24723	PRKCH	Protein kinase C eta type	Q13761	RUNX3	Runt-related transcription factor 3	0.915
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725

Hydrocortisone

Th17 cell differentiation

3.91E-03

Q04759, Q16539, P06239, P13765, P14778, Q9UL17, P23771, P09693, P20963

PRKCQ, MAPK14, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877

Hydrocortisone

T cell receptor signaling pathway

6.95E-04

P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743

Hydrocortisone

TNF signaling pathway

4.74E-02

Q99941, P01584, O95429

CREBL1, IL1B, BAG4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756

Hydrocortisone

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75

Hydrocortisone

Inflammatory mediator regulation of TRP channels

4.46E-03

P14778, P01584, P51828, P22694, Q13557, Q16539, Q14643, Q04759

IL1R1, IL1B, ADCY7, PRKACB, CAMK2D, MAPK14, ITPR1, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P24723	PRKCH	Protein kinase C eta type	P24723	PRKCH	Protein kinase C eta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Hydrocortisone

Insulin secretion

1.48E-02

P51828, Q99941, Q13557

ADCY7, CREBL1, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone

hsa04914

Progesterone-mediated oocyte maturation

2.94E-02

Q17RY0, P51812, Q02750

CPEB4, RPS6KA3, MAP2K1

Hydrocortisone

Estrogen signaling pathway

4.72E-02

Q99941, P51828, P07900, P11142

CREBL1, ADCY7, HSP90AA1, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Hydrocortisone

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Hydrocortisone

Aldosterone synthesis and secretion

5.19E-03

Q99941, P51828, Q13557, P23634

CREBL1, ADCY7, CAMK2D, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Hydrocortisone

Cushing syndrome

3.48E-03

Q99941, P51828, O15169, Q13557

CREBL1, ADCY7, AXIN1, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Hydrocortisone

Collecting duct acid secretion

4.93E-02

P00918

CA2

Hydrocortisone

Gastric acid secretion

1.48E-02

P51828, P15311, Q13557

ADCY7, VIL2, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Hydrocortisone

Bile secretion

2.44E-02

P22694, P08183

PRKACB, ABCB1

Hydrocortisone

Alzheimer disease

1.46E-03

Q92542, P05496, Q06055, P12074, O75460, P01584, O15169, P45880, P17861, P62195

NCSTN, ATP5G1, ATP5G2, COX6A1, ERN1, IL1B, AXIN1, VDAC2, XBP1, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814

Hydrocortisone

Parkinson disease

5.41E-03

Q06055, P17861, P62195

ATP5G2, XBP1, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725

Hydrocortisone

Amyotrophic lateral sclerosis

1.01E-02

Q06055, P17861, P62195

ATP5G2, XBP1, PSMC5

Hydrocortisone

Spinocerebellar ataxia

1.42E-02

P17861, P62195

XBP1, PSMC5

Hydrocortisone

Prion disease

1.81E-02

P01584, P46531, P11142, P05496, P12074, P45880, Q99941

IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769

Hydrocortisone

Pathways of neurodegeneration - multiple diseases

1.66E-02

Q06055, P17861, P62195

ATP5G2, XBP1, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814

Hydrocortisone

Alcoholism

2.05E-05

Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431

HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Hydrocortisone

Salmonella infection

9.85E-03

Q13546, Q13489, O60282, P68371

RIPK1, BIRC3, KIF5C, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
Q05655	PRKCD	Protein kinase C delta type	P84095	RHOG	Rho-related GTP-binding protein RhoG	0.71
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
Q05655	PRKCD	Protein kinase C delta type	P84095	RHOG	Rho-related GTP-binding protein RhoG	0.71
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747

Hydrocortisone

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Hydrocortisone

Legionellosis

5.53E-03

Q9NR31, P68104

SAR1A, EEF1A1

Hydrocortisone

Yersinia infection

3.72E-02

P13612, P06239, Q16539, P01375, P49841, P01732

ITGA4, LCK, MAPK14, TNF, GSK3B, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77

Hydrocortisone

Leishmaniasis

2.69E-02

P13612, O75015, P13765, O60603, P01375, Q16539

ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754

Hydrocortisone

hsa05143

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Hydrocortisone

Malaria

9.96E-05

P60033, P69905, P68871, O60603, P01375, P35443, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919

Hydrocortisone

Amoebiasis

5.94E-04

P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311

CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P24723	PRKCH	Protein kinase C eta type	P05089	ARG1	Arginase-1	-0.749
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P24723	PRKCH	Protein kinase C eta type	P12814	ACTN1	Alpha-actinin-1	-0.869
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P24723	PRKCH	Protein kinase C eta type	P08311	CTSG	Cathepsin G	-0.744
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867

Hydrocortisone

Staphylococcus aureus infection

1.02E-03

P21730, P21462, O75015, P59665, P59666, P12838, P49913

C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774

Hydrocortisone

Human cytomegalovirus infection

2.51E-02

P01375, Q14643, P22694, P49841, P14778, Q13651, P25025, Q16539, O00463

TNF, ITPR1, PRKACB, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896

Hydrocortisone

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Hydrocortisone

hsa05170

Human immunodeficiency virus 1 infection

6.02E-03

Q02750, P62879, P16298, Q05397, P20333

MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Hydrocortisone

Transcriptional misregulation in cancer

4.29E-03

P14780, P27930, Q15744, Q16548, P11215, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522

MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863

Hydrocortisone

Viral carcinogenesis

1.22E-03

Q13547, Q15283, P58876, P62807, Q16778, O60814

HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Hydrocortisone

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Hydrocortisone

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769

Hydrocortisone

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Hydrocortisone

hsa05226

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Hydrocortisone

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Hydrocortisone

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.42E-02

O95267, P20963, P09693, P06239, O60603, Q04759, Q16539

RASGRP1, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84

Hydrocortisone

Asthma

1.62E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Hydrocortisone

Inflammatory bowel disease

1.09E-03

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832

Hydrocortisone

Systemic lupus erythematosus

4.80E-06

P09871, Q93077, P58876, P62807, Q16778, O60814, P68431

C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Hydrocortisone

Graft-versus-host disease

1.76E-02

P13765, P01375, P26715, Q13241

HLA-DOB, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84

Hydrocortisone

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Hydrocortisone

Diabetic cardiomyopathy

3.59E-02

P11413

G6PD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1

Hydrocortisone-valerate

hsa00020

Citrate cycle (TCA cycle)

3.41E-02

P50213, O14521

IDH3A, SDHD

Hydrocortisone-valerate

Pentose phosphate pathway

8.97E-03

P11413

G6PD

Hydrocortisone-valerate

hsa00190

Oxidative phosphorylation

4.36E-03

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Hydrocortisone-valerate

Arginine biosynthesis

1.94E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
P60033	CD81	CD81 antigen	P15104	GLUL	Glutamine synthetase	-0.841
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
P60033	CD81	CD81 antigen	P05089	ARG1	Arginase-1	-0.782
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
P60033	CD81	CD81 antigen	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05089	ARG1	Arginase-1	0.794
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.755

Hydrocortisone-valerate

Alanine, aspartate and glutamate metabolism

4.32E-02

P49448, P15104

GLUD2, GLUL

Hydrocortisone-valerate

Glutathione metabolism

2.60E-05

Q9UJ14, P11413, Q16772, P09211, P30041

GGTL3, G6PD, GSTA3, GSTP1, PRDX6

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75

Hydrocortisone-valerate

Starch and sucrose metabolism

1.18E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
O43451	MGAM	Maltase-glucoamylase	O43451	MGAM	Maltase-glucoamylase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
O43451	MGAM	Maltase-glucoamylase	P46976	GYG1	Glycogenin-1	0.877
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
O43451	MGAM	Maltase-glucoamylase	P06737	PYGL	Glycogen phosphorylase, liver form	0.87
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
P08183	ABCB1	ATP-dependent translocase ABCB1	O43451	MGAM	Maltase-glucoamylase	-0.732
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
P08183	ABCB1	ATP-dependent translocase ABCB1	P06737	PYGL	Glycogen phosphorylase, liver form	-0.799
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O43451	MGAM	Maltase-glucoamylase	0.884
P12429	ANXA3	Annexin A3	O43451	MGAM	Maltase-glucoamylase	0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P46976	GYG1	Glycogenin-1	0.982
P12429	ANXA3	Annexin A3	P46976	GYG1	Glycogenin-1	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06737	PYGL	Glycogen phosphorylase, liver form	0.735
P12429	ANXA3	Annexin A3	P06737	PYGL	Glycogen phosphorylase, liver form	0.887

Hydrocortisone-valerate

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Hydrocortisone-valerate

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Hydrocortisone-valerate

Thiamine metabolism

4.32E-02

P05186, P24666

ALPL, ACP1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7
P08183	ABCB1	ATP-dependent translocase ABCB1	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	-0.703
P08183	ABCB1	ATP-dependent translocase ABCB1	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.869
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.7

Hydrocortisone-valerate

Nitrogen metabolism

4.32E-02

P15104, P49448

GLUL, GLUD2

Hydrocortisone-valerate

Aminoacyl-tRNA biosynthesis

1.21E-02

P14868

DARS

Hydrocortisone-valerate

Metabolism of xenobiotics by cytochrome P450

9.14E-05

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Hydrocortisone-valerate

Drug metabolism - cytochrome P450

1.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Hydrocortisone-valerate

Drug metabolism - other enzymes

1.72E-02

Q16772, P09211

GSTA3, GSTP1

Hydrocortisone-valerate

Metabolic pathways

8.43E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731

Hydrocortisone-valerate

Carbon metabolism

2.91E-02

P11413

G6PD

Hydrocortisone-valerate

hsa01230

Biosynthesis of amino acids

3.91E-02

P51854, Q99707, P50213

TKTL1, MTR, IDH3A

Hydrocortisone-valerate

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Hydrocortisone-valerate

RNA transport

9.39E-05

Q15287, Q9UBU9, P35658, P63279, P68104, P55884, O15371, P20042, Q14232

RNPS1, NXF1, NUP214, UBE2I, EEF1A1, EIF3B, EIF3D, EIF2S2, EIF2B1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P08758	ANXA5	Annexin A5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.776
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P08758	ANXA5	Annexin A5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.716

Hydrocortisone-valerate

Spliceosome

3.98E-02

Q15427, P38159, P61978, P11142

SF3B4, RBMX, HNRPK, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Hydrocortisone-valerate

Protein export

9.07E-04

P37108, Q15005

SRP14, SPCS2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726
P01584	IL1B	Interleukin-1 beta	P37108	SRP14	Signal recognition particle 14 kDa protein	0.793
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P37108	SRP14	Signal recognition particle 14 kDa protein	0.729
P01584	IL1B	Interleukin-1 beta	Q15005	SPCS2	Signal peptidase complex subunit 2	0.741
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15005	SPCS2	Signal peptidase complex subunit 2	0.726

Hydrocortisone-valerate

ErbB signaling pathway

3.74E-02

P21860, Q13557, O14944

ERBB3, CAMK2D, EREG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.738

Hydrocortisone-valerate

Calcium signaling pathway

2.19E-05

Q96DU7, Q08828, P45880, Q13557, P21860, P61073, P0DP24, P05141, P51828, P23634

ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, CXCR4, CALM2, SLC25A5, ADCY7, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.802
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone-valerate

cGMP-PKG signaling pathway

2.45E-03

Q99941, P18848, P23634, Q08828, P51828, P05141, P45880, P0DP24

CREBL1, ATF4, ATP2B4, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone-valerate

Viral protein interaction with cytokine and cytokine receptor

9.15E-04

Q8NHW4, P09341, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P01375

CCL4L2, CXCL1, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.836
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P12429	ANXA3	Annexin A3	P47992	XCL1	Lymphotactin	-0.851
P12429	ANXA3	Annexin A3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.851
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-valerate

Chemokine signaling pathway

3.13E-02

P25024, P25025, P07948, P42338, P63218, P50151, P49407, P49841

CXCR1, CXCR2, LYN, PIK3CB, GNG5, GNG10, ARRB1, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P60033	CD81	CD81 antigen	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.873
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P60033	CD81	CD81 antigen	P49407	ARRB1	Beta-arrestin-1	0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Hydrocortisone-valerate

NF-kappa B signaling pathway

9.08E-04

Q13489, Q13546, P01584, Q9UDY8, P63279, Q8NHW4, Q9UNE0, Q9NQC7

BIRC3, RIPK1, IL1B, MALT1, UBE2I, CCL4L2, EDAR, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P01584	IL1B	Interleukin-1 beta	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.815
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805

Hydrocortisone-valerate

Oocyte meiosis

4.36E-02

Q13557, P0DP24, Q08828, P51828, P27348

CAMK2D, CALM2, ADCY1, ADCY7, YWHAQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q17RY0	CPEB4	Cytoplasmic polyadenylation element-binding protein 4	0.79
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P27348	YWHAQ	14-3-3 protein theta	0.751

Hydrocortisone-valerate

Autophagy - animal

3.61E-02

Q9NQL2, P22694, Q14643, Q9H1Y0, Q04759

RRAGD, PRKACB, ITPR1, ATG5, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	Q9Y4H2	IRS2	Insulin receptor substrate 2	-0.716
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	-0.701
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.743
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906

Hydrocortisone-valerate

Protein processing in endoplasmic reticulum

5.75E-03

Q99941, O75460, P17861, P11142, Q9H3Z4, P07900, Q9NR31

CREBL1, ERN1, XBP1, HSPA8, DNAJC5, HSP90AA1, SAR1A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08758	ANXA5	Annexin A5	Q9NR31	SAR1A	GTP-binding protein SAR1a	0.791

Hydrocortisone-valerate

mTOR signaling pathway

2.72E-02

P42338, Q9NQL2, Q13322, P49841

PIK3CB, RRAGD, GRB10, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P11511	CYP19A1	Aromatase	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.806
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9NQL2	RRAGD	Ras-related GTP-binding protein D	0.834
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13322	GRB10	Growth factor receptor-bound protein 10	0.898
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Hydrocortisone-valerate

Longevity regulating pathway

3.41E-03

Q12778, Q08828, P51828, Q99941, P18848, Q9UEF7, Q96KQ7

FOXO1, ADCY1, ADCY7, CREBL1, ATF4, KL, EHMT2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72
P08235	NR3C2	Mineralocorticoid receptor	Q12778	FOXO1	Forkhead box protein O1	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08235	NR3C2	Mineralocorticoid receptor	Q9UEF7	KL	Klotho	0.775
P08235	NR3C2	Mineralocorticoid receptor	Q96KQ7	EHMT2	Histone-lysine N-methyltransferase EHMT2	0.72

Hydrocortisone-valerate

Longevity regulating pathway - multiple species

2.85E-02

Q9Y4H2, Q13547

IRS2, HDAC1

Hydrocortisone-valerate

Necroptosis

6.23E-04

P01568, P23458, Q13489, Q9NQC7, Q13546, P05141, P01584, P0C0S5, Q13557, Q9H444

IFNA21, JAK1, BIRC3, CYLD, RIPK1, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0C0S5	H2AFZ	Histone H2A.Z	0.762
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.716

Hydrocortisone-valerate

Adrenergic signaling in cardiomyocytes

1.60E-03

Q08828, P51828, Q99941, P18848, P0DP24, Q13557, P23634

ADCY1, ADCY7, CREBL1, ATF4, CALM2, CAMK2D, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P17252	PRKCA	Protein kinase C alpha type	P09493	TPM1	Tropomyosin alpha-1 chain	0.78
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone-valerate

Notch signaling pathway

4.34E-02

Q92542, P46531

NCSTN, NOTCH1

Hydrocortisone-valerate

Osteoclast differentiation

6.08E-03

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P42338, P01584, P14778, O75015, Q8N149

CYLD, GAB2, MAPK14, JAK1, LCK, PIK3CB, IL1B, IL1R1, FCGR3B, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	-0.737
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P01584	IL1B	Interleukin-1 beta	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.805
P01584	IL1B	Interleukin-1 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.722
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764

Hydrocortisone-valerate

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Hydrocortisone-valerate

Antigen processing and presentation

3.60E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
Q14145	KEAP1	Kelch-like ECH-associated protein 1	O43908	KLRC4	NKG2-F type II integral membrane protein	0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P01375	TNF	Tumor necrosis factor	P48382	RFX5	DNA-binding protein RFX5	-0.796
P12429	ANXA3	Annexin A3	P48382	RFX5	DNA-binding protein RFX5	-0.756
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.809
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-valerate

Neutrophil extracellular trap formation

4.90E-05

P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431, P20160, P08311, O75015, P21730, O43315, Q16539

ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AZU1, CTSG, FCGR3B, C5AR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
P12429	ANXA3	Annexin A3	Q16778	HIST2H2BE	Histone H2B type 2-E	0.7
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P12429	ANXA3	Annexin A3	P20160	AZU1	Azurocidin	0.804
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.887
P12429	ANXA3	Annexin A3	O43315	AQP9	Aquaporin-9	0.789
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805

Hydrocortisone-valerate

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Hydrocortisone-valerate

NOD-like receptor signaling pathway

3.13E-04

Q16539, Q14643, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, Q13546, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838

MAPK14, ITPR1, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, RIPK1, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P12838	DEFA4	Neutrophil defensin 4	-0.754
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P52630	STAT2	Signal transducer and activator of transcription 2	-0.828
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P10599	TXN	Thioredoxin	-0.71
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P12838	DEFA4	Neutrophil defensin 4	-0.754
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P12429	ANXA3	Annexin A3	P10599	TXN	Thioredoxin	0.871
P01375	TNF	Tumor necrosis factor	Q9H1Y0	ATG5	Autophagy protein 5	-0.811
P12429	ANXA3	Annexin A3	Q9H1Y0	ATG5	Autophagy protein 5	-0.717
P01375	TNF	Tumor necrosis factor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.78
P12429	ANXA3	Annexin A3	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.908
P01375	TNF	Tumor necrosis factor	O00463	TRAF5	TNF receptor-associated factor 5	-0.816
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P12429	ANXA3	Annexin A3	P29728	OAS2	2'-5'-oligoadenylate synthase 2	-0.751
P01375	TNF	Tumor necrosis factor	Q05823	RNASEL	2-5A-dependent ribonuclease	0.853
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899

Hydrocortisone-valerate

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Hydrocortisone-valerate

Cytosolic DNA-sensing pathway

5.86E-05

P01584, P01568, Q13546, Q8NHW4

IL1B, IFNA21, RIPK1, CCL4L2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P08235	NR3C2	Mineralocorticoid receptor	P01568	IFNA21	Interferon alpha-21	0.757
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766

Hydrocortisone-valerate

Hematopoietic cell lineage

1.10E-02

P13612, P14778, P27930, P15144, P25063, P09693, P01732, P13765, P01375

ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P24723	PRKCH	Protein kinase C eta type	P25063	CD24	Signal transducer CD24	-0.838
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P09564	CD7	T-cell antigen CD7	0.865
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
O43451	MGAM	Maltase-glucoamylase	P15144	ANPEP	Aminopeptidase N	0.726
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P15144	ANPEP	Aminopeptidase N	0.762
P12429	ANXA3	Annexin A3	P25063	CD24	Signal transducer CD24	0.813
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-valerate

Natural killer cell mediated cytotoxicity

3.11E-04

P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715

TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.835
P60033	CD81	CD81 antigen	O60880	SH2D1A	SH2 domain-containing protein 1A	0.726
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P24723	PRKCH	Protein kinase C eta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.822
P60033	CD81	CD81 antigen	P26718	KLRK1	NKG2-D type II integral membrane protein	0.791
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P24723	PRKCH	Protein kinase C eta type	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.828
P60033	CD81	CD81 antigen	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.757
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
O43451	MGAM	Maltase-glucoamylase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.804
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
O43451	MGAM	Maltase-glucoamylase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.759
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
O43451	MGAM	Maltase-glucoamylase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
O43451	MGAM	Maltase-glucoamylase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.802
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
O43451	MGAM	Maltase-glucoamylase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.71
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
O43451	MGAM	Maltase-glucoamylase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.71
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P01375	TNF	Tumor necrosis factor	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.717
P12429	ANXA3	Annexin A3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.833
P01375	TNF	Tumor necrosis factor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.727
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P01375	TNF	Tumor necrosis factor	Q13241	KLRD1	Natural killer cells antigen CD94	-0.769
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P01375	TNF	Tumor necrosis factor	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.83
P01375	TNF	Tumor necrosis factor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.814
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83

Hydrocortisone-valerate

IL-17 signaling pathway

1.42E-02

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.708
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.733
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.708
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.791
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832

Hydrocortisone-valerate

Th1 and Th2 cell differentiation

5.29E-06

Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P24723	PRKCH	Protein kinase C eta type	Q13761	RUNX3	Runt-related transcription factor 3	0.915
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725

Hydrocortisone-valerate

Th17 cell differentiation

1.31E-04

Q04759, Q16539, P01730, P06239, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, MAPK14, CD4, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
O43451	MGAM	Maltase-glucoamylase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.771
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877

Hydrocortisone-valerate

T cell receptor signaling pathway

6.26E-05

P01375, Q04759, P42338, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, PIK3CB, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P60033	CD81	CD81 antigen	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.726
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P60033	CD81	CD81 antigen	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.749
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.712
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.814
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743

Hydrocortisone-valerate

B cell receptor signaling pathway

2.80E-03

P49841, P42338, P60033, P07948, P21854, Q8N149

GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P24723	PRKCH	Protein kinase C eta type	P60033	CD81	CD81 antigen	0.711
P60033	CD81	CD81 antigen	P60033	CD81	CD81 antigen	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P60033	CD81	CD81 antigen	-0.83
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P24723	PRKCH	Protein kinase C eta type	P21854	CD72	B-cell differentiation antigen CD72	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P21854	CD72	B-cell differentiation antigen CD72	-0.705
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
P24723	PRKCH	Protein kinase C eta type	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.765
P60033	CD81	CD81 antigen	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	-0.78
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.878
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P60033	CD81	CD81 antigen	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P21854	CD72	B-cell differentiation antigen CD72	-0.787
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.764

Hydrocortisone-valerate

Fc epsilon RI signaling pathway

1.80E-02

Q16539, P42338, P07948, P09917

MAPK14, PIK3CB, LYN, ALOX5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P60033	CD81	CD81 antigen	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.83
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.796

Hydrocortisone-valerate

TNF signaling pathway

4.74E-02

Q99941, P01584, O95429

CREBL1, IL1B, BAG4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O95429	BAG4	BAG family molecular chaperone regulator 4	0.756

Hydrocortisone-valerate

Circadian entrainment

1.91E-02

P0DP24, Q13557, Q08828, P51828

CALM2, CAMK2D, ADCY1, ADCY7

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815

Hydrocortisone-valerate

Long-term potentiation

1.91E-02

Q13557, P0DP24, P18848, Q08828

CAMK2D, CALM2, ATF4, ADCY1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	0.762
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75

Hydrocortisone-valerate

hsa04721

Synaptic vesicle cycle

1.80E-02

Q13488, P31645

TCIRG1, SLC6A4

Hydrocortisone-valerate

Retrograde endocannabinoid signaling

3.86E-02

P63218, P50151, P48058, Q16539

GNG5, GNG10, GRIA4, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817

Hydrocortisone-valerate

Glutamatergic synapse

7.09E-03

P48058, P43003, P63218, P50151, P15104

GRIA4, SLC1A3, GNG5, GNG10, GLUL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P43003	SLC1A3	Excitatory amino acid transporter 1	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P15104	GLUL	Glutamine synthetase	0.84

Hydrocortisone-valerate

Cholinergic synapse

3.77E-02

Q08828, P51828, P18848, Q13557

ADCY1, ADCY7, ATF4, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725

Hydrocortisone-valerate

Dopaminergic synapse

1.73E-03

P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407, P0DP24, O15516, P48058

GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, CALM2, CLOCK, GRIA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	O15516	CLOCK	Circadian locomoter output cycles protein kaput	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P48058	GRIA4	Glutamate receptor 4	0.701

Hydrocortisone-valerate

Inflammatory mediator regulation of TRP channels

7.58E-05

P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, Q14643, Q04759, P0DP24

IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, ITPR1, PRKCQ, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P24723	PRKCH	Protein kinase C eta type	P24723	PRKCH	Protein kinase C eta type	1
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone-valerate

Insulin secretion

2.95E-05

Q08828, P51828, Q99941, P18848, Q13557

ADCY1, ADCY7, CREBL1, ATF4, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone-valerate

GnRH signaling pathway

6.99E-03

Q08828, P51828, P18848, Q13557, P0DP24

ADCY1, ADCY7, ATF4, CAMK2D, CALM2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72

Hydrocortisone-valerate

Estrogen signaling pathway

4.72E-02

Q99941, P51828, P07900, P11142

CREBL1, ADCY7, HSP90AA1, HSPA8

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766

Hydrocortisone-valerate

Melanogenesis

7.61E-03

Q13557, P0DP24, Q08828, P51828

CAMK2D, CALM2, ADCY1, ADCY7

Hydrocortisone-valerate

Thyroid hormone synthesis

4.47E-03

Q08828, P51828, Q99941, P18848, P02768

ADCY1, ADCY7, CREBL1, ATF4, ALB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P02768	ALB	Albumin	0.718

Hydrocortisone-valerate

Aldosterone synthesis and secretion

8.00E-06

Q99941, P18848, Q08828, P51828, P0DP24, Q13557, P23634

CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.73

Hydrocortisone-valerate

Cortisol synthesis and secretion

4.16E-03

Q99941, P18848, Q08828, P51828

CREBL1, ATF4, ADCY1, ADCY7

Hydrocortisone-valerate

Parathyroid hormone synthesis, secretion and action

3.77E-02

Q08828, P51828, Q99941, P18848

ADCY1, ADCY7, CREBL1, ATF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749

Hydrocortisone-valerate

Non-alcoholic fatty liver disease

3.45E-02

P18848, O75460, P01584, P12074, O15239

ATF4, ERN1, IL1B, COX6A1, NDUFA1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783

Hydrocortisone-valerate

Cushing syndrome

2.69E-06

Q99941, P18848, Q08828, P51828, O15169, Q13557

CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone-valerate

Growth hormone synthesis, secretion and action

4.98E-02

Q08828, P51828, Q99941, P18848

ADCY1, ADCY7, CREBL1, ATF4

Hydrocortisone-valerate

Salivary secretion

3.54E-02

Q08828, P51828, P0DP24

ADCY1, ADCY7, CALM2

Hydrocortisone-valerate

Gastric acid secretion

2.95E-05

Q08828, P51828, P15311, P0DP24, Q13557

ADCY1, ADCY7, VIL2, CALM2, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P51828	ADCY7	Adenylate cyclase type 7	0.704
P01584	IL1B	Interleukin-1 beta	P15311	VIL2	Ezrin	0.788
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.707

Hydrocortisone-valerate

Carbohydrate digestion and absorption

1.57E-02

O43451, P42338

MGAM, PIK3CB

Hydrocortisone-valerate

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Hydrocortisone-valerate

Alzheimer disease

2.56E-05

Q92542, O15239, P05496, Q06055, P12074, Q00535, O75460, P0DP24, P01584, P18848, O15169, P05141, P45880, P17861, P28070, P43686, P62195

NCSTN, NDUFA1, ATP5G1, ATP5G2, COX6A1, CDK5, ERN1, CALM2, IL1B, ATF4, AXIN1, SLC25A5, VDAC2, XBP1, PSMB4, PSMC4, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P60033	CD81	CD81 antigen	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.714
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P60033	CD81	CD81 antigen	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.774
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P60033	CD81	CD81 antigen	Q92837	FRAT1	Proto-oncogene FRAT1	-0.731
P60033	CD81	CD81 antigen	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.751
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P60033	CD81	CD81 antigen	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.78
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q92542	NCSTN	Nicastrin	0.706
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15169	AXIN1	Axin-1	0.742
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814

Hydrocortisone-valerate

Parkinson disease

5.28E-04

O15239, P12074, Q06055, P05141, O75460, P18848, P17861, P28070, P43686, P62195, P0DP24, Q13557

NDUFA1, COX6A1, ATP5G2, SLC25A5, ERN1, ATF4, XBP1, PSMB4, PSMC4, PSMC5, CALM2, CAMK2D

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725

Hydrocortisone-valerate

Amyotrophic lateral sclerosis

1.01E-02

Q06055, P17861, P62195

ATP5G2, XBP1, PSMC5

Hydrocortisone-valerate

Huntington disease

3.54E-02

O15239, P12074, P24928, P62487, P05141, O75460, P28070, P43686

NDUFA1, COX6A1, POLR2A, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P01584	IL1B	Interleukin-1 beta	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.872
P01584	IL1B	Interleukin-1 beta	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.839
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723

Hydrocortisone-valerate

Spinocerebellar ataxia

1.42E-02

P17861, P62195

XBP1, PSMC5

Hydrocortisone-valerate

Prion disease

1.76E-03

P01584, P46531, P11142, O15239, P05496, P12074, P18848, P05141, P45880, P28070, P43686, Q99941

IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX6A1, ATF4, SLC25A5, VDAC2, PSMB4, PSMC4, CREBL1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P01584	IL1B	Interleukin-1 beta	0.75
P01584	IL1B	Interleukin-1 beta	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.733
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.754
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	0.708
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769

Hydrocortisone-valerate

Pathways of neurodegeneration - multiple diseases

2.12E-04

O15239, P12074, Q06055, Q8TEV9, O75460, P18848, P17861, P05141, Q00535, O15169, P01584, P0DP24, Q13557, P28070, P43686, P62195

NDUFA1, COX6A1, ATP5G2, SMCR8, ERN1, ATF4, XBP1, SLC25A5, CDK5, AXIN1, IL1B, CALM2, CAMK2D, PSMB4, PSMC4, PSMC5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814
P01584	IL1B	Interleukin-1 beta	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.783
P01584	IL1B	Interleukin-1 beta	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.744
P08758	ANXA5	Annexin A5	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	0.731
P01584	IL1B	Interleukin-1 beta	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.705
P01584	IL1B	Interleukin-1 beta	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.826
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P08758	ANXA5	Annexin A5	P17861	XBP1	X-box-binding protein 1	0.779
P01584	IL1B	Interleukin-1 beta	P05141	SLC25A5	ADP/ATP translocase 2	0.768
P01584	IL1B	Interleukin-1 beta	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.735
P01584	IL1B	Interleukin-1 beta	O15169	AXIN1	Axin-1	0.7
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.725
P01584	IL1B	Interleukin-1 beta	P28070	PSMB4	Proteasome subunit beta type-4	0.734
P01584	IL1B	Interleukin-1 beta	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.723
P08758	ANXA5	Annexin A5	P62195	PSMC5	26S proteasome regulatory subunit 8	0.814

Hydrocortisone-valerate

Cocaine addiction

3.54E-02

Q00535, Q99941, P18848

CDK5, CREBL1, ATF4

Hydrocortisone-valerate

Amphetamine addiction

7.61E-03

P0DP24, Q13557, Q99941, P18848

CALM2, CAMK2D, CREBL1, ATF4

Hydrocortisone-valerate

Alcoholism

2.05E-05

Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431

HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Hydrocortisone-valerate

Epithelial cell signaling in Helicobacter pylori infection

2.72E-02

Q16539, P25024, P25025, P07948

MAPK14, CXCR1, CXCR2, LYN

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25024	CXCR1	C-X-C chemokine receptor type 1	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
O43451	MGAM	Maltase-glucoamylase	P25024	CXCR1	C-X-C chemokine receptor type 1	0.895
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
O43451	MGAM	Maltase-glucoamylase	P25025	CXCR2	C-X-C chemokine receptor type 2	0.942
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795

Hydrocortisone-valerate

Salmonella infection

9.85E-03

Q13546, Q13489, O60282, P68371

RIPK1, BIRC3, KIF5C, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
Q05655	PRKCD	Protein kinase C delta type	P84095	RHOG	Rho-related GTP-binding protein RhoG	0.71
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
Q05655	PRKCD	Protein kinase C delta type	P84095	RHOG	Rho-related GTP-binding protein RhoG	0.71
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
Q05655	PRKCD	Protein kinase C delta type	P07737	PFN1	Profilin-1	0.77
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.701
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08235	NR3C2	Mineralocorticoid receptor	O60282	KIF5C	Kinesin heavy chain isoform 5C	0.753
P08235	NR3C2	Mineralocorticoid receptor	P68371	TUBB2C	Tubulin beta-4B chain	-0.747

Hydrocortisone-valerate

Legionellosis

5.53E-03

Q9NR31, P68104

SAR1A, EEF1A1

Hydrocortisone-valerate

Yersinia infection

1.11E-03

P13612, P06239, Q16539, P01375, P42338, P49841, P01730, P01732

ITGA4, LCK, MAPK14, TNF, PIK3CB, GSK3B, CD4, CD8A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P60033	CD81	CD81 antigen	P13612	ITGA4	Integrin alpha-4	0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P60033	CD81	CD81 antigen	P06239	LCK	Tyrosine-protein kinase Lck	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
O43451	MGAM	Maltase-glucoamylase	P13612	ITGA4	Integrin alpha-4	-0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
O43451	MGAM	Maltase-glucoamylase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
O43451	MGAM	Maltase-glucoamylase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.764
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P13612	ITGA4	Integrin alpha-4	-0.729
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.77

Hydrocortisone-valerate

Leishmaniasis

5.15E-04

P13612, O75015, P14598, P13765, O60603, P25963, P01375, P29350, Q16539, Q15080

ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	P13612	ITGA4	Integrin alpha-4	-0.806
P12429	ANXA3	Annexin A3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.816
P49336	CDK8	Cyclin-dependent kinase 8	P14598	NCF1	Neutrophil cytosol factor 1	-0.721
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P49336	CDK8	Cyclin-dependent kinase 8	O60603	TLR2	Toll-like receptor 2	-0.734
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P49336	CDK8	Cyclin-dependent kinase 8	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P49336	CDK8	Cyclin-dependent kinase 8	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.726
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P49336	CDK8	Cyclin-dependent kinase 8	Q15080	NCF4	Neutrophil cytosol factor 4	-0.754

Hydrocortisone-valerate

Malaria

6.84E-04

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P00918	CA2	Carbonic anhydrase 2	P69905	HBA2	Hemoglobin subunit alpha	0.759
P00918	CA2	Carbonic anhydrase 2	P68871	HBB	Hemoglobin subunit beta	0.72
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919
P01375	TNF	Tumor necrosis factor	P60033	CD81	CD81 antigen	-0.71
P12429	ANXA3	Annexin A3	P60033	CD81	CD81 antigen	-0.766
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P01375	TNF	Tumor necrosis factor	P01375	TNF	Tumor necrosis factor	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P01375	TNF	Tumor necrosis factor	P35443	THBS4	Thrombospondin-4	0.812
P12429	ANXA3	Annexin A3	P35443	THBS4	Thrombospondin-4	0.887
P01375	TNF	Tumor necrosis factor	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.754
P12429	ANXA3	Annexin A3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.919

Hydrocortisone-valerate

Amoebiasis

5.94E-04

P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311

CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P24723	PRKCH	Protein kinase C eta type	P05089	ARG1	Arginase-1	-0.749
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P24723	PRKCH	Protein kinase C eta type	P12814	ACTN1	Alpha-actinin-1	-0.869
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P24723	PRKCH	Protein kinase C eta type	P08311	CTSG	Cathepsin G	-0.744
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
O43451	MGAM	Maltase-glucoamylase	P09341	CXCL1	Growth-regulated alpha protein	0.807
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
O43451	MGAM	Maltase-glucoamylase	P14778	IL1R1	Interleukin-1 receptor type 1	0.924
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
O43451	MGAM	Maltase-glucoamylase	P27930	IL1R2	Interleukin-1 receptor type 2	0.958
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
O43451	MGAM	Maltase-glucoamylase	P05089	ARG1	Arginase-1	0.831
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
O43451	MGAM	Maltase-glucoamylase	P12814	ACTN1	Alpha-actinin-1	0.782
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
O43451	MGAM	Maltase-glucoamylase	P08311	CTSG	Cathepsin G	0.717
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867
P12429	ANXA3	Annexin A3	P09341	CXCL1	Growth-regulated alpha protein	0.892
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P05089	ARG1	Arginase-1	0.969
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P12814	ACTN1	Alpha-actinin-1	0.797
P12429	ANXA3	Annexin A3	P08311	CTSG	Cathepsin G	0.867

Hydrocortisone-valerate

Staphylococcus aureus infection

1.02E-03

P21730, P21462, O75015, P59665, P59666, P12838, P49913

C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774
P01375	TNF	Tumor necrosis factor	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.774
P01375	TNF	Tumor necrosis factor	P21462	FPR1	fMet-Leu-Phe receptor	0.77
P01375	TNF	Tumor necrosis factor	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.838
P01375	TNF	Tumor necrosis factor	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	0.723
P01375	TNF	Tumor necrosis factor	P59666	DEFA3	Neutrophil defensin 3	0.723
P01375	TNF	Tumor necrosis factor	P12838	DEFA4	Neutrophil defensin 4	0.922
P01375	TNF	Tumor necrosis factor	P49913	CAMP	Cathelicidin antimicrobial peptide	0.774

Hydrocortisone-valerate

Human cytomegalovirus infection

8.52E-07

P42338, P01375, P63218, P50151, Q14643, P0DP24, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, Q99941, P18848, O00463

PIK3CB, TNF, GNG5, GNG10, ITPR1, CALM2, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P60033	CD81	CD81 antigen	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.818
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P60033	CD81	CD81 antigen	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P60033	CD81	CD81 antigen	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.774
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
P60033	CD81	CD81 antigen	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.808
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P60033	CD81	CD81 antigen	P14778	IL1R1	Interleukin-1 receptor type 1	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P60033	CD81	CD81 antigen	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.76
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P12429	ANXA3	Annexin A3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.75
P01584	IL1B	Interleukin-1 beta	P0DP24	CALM2	Calmodulin-2	0.72
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.766
P01584	IL1B	Interleukin-1 beta	Q08828	ADCY1	Adenylate cyclase type 1	0.75
P01584	IL1B	Interleukin-1 beta	P51828	ADCY7	Adenylate cyclase type 7	0.815
P12429	ANXA3	Annexin A3	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.754
P01584	IL1B	Interleukin-1 beta	P23458	JAK1	Tyrosine-protein kinase JAK1	0.799
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P12429	ANXA3	Annexin A3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.743
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P12429	ANXA3	Annexin A3	P14778	IL1R1	Interleukin-1 receptor type 1	0.749
P01584	IL1B	Interleukin-1 beta	P01584	IL1B	Interleukin-1 beta	1
P01584	IL1B	Interleukin-1 beta	P61073	CXCR4	C-X-C chemokine receptor type 4	0.825
P01584	IL1B	Interleukin-1 beta	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.82
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.769
P12429	ANXA3	Annexin A3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.716
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P12429	ANXA3	Annexin A3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.857
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
P01584	IL1B	Interleukin-1 beta	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.704
P01584	IL1B	Interleukin-1 beta	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.749
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P12429	ANXA3	Annexin A3	O00463	TRAF5	TNF receptor-associated factor 5	-0.896

Hydrocortisone-valerate

Epstein-Barr virus infection

2.32E-02

Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, P07766, P20963

HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P60033	CD81	CD81 antigen	Q13547	HDAC1	Histone deacetylase 1	0.703
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
P60033	CD81	CD81 antigen	O00463	TRAF5	TNF receptor-associated factor 5	0.756
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P60033	CD81	CD81 antigen	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.714
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P60033	CD81	CD81 antigen	P07948	LYN	Tyrosine-protein kinase Lyn	-0.884
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P60033	CD81	CD81 antigen	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.719
P60033	CD81	CD81 antigen	P30101	PDIA3	Protein disulfide-isomerase A3	0.708
P60033	CD81	CD81 antigen	Q13761	RUNX3	Runt-related transcription factor 3	0.792
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P60033	CD81	CD81 antigen	P01375	TNF	Tumor necrosis factor	-0.71
P60033	CD81	CD81 antigen	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P60033	CD81	CD81 antigen	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775

Hydrocortisone-valerate

Transcriptional misregulation in cancer

4.29E-03

P14780, P27930, Q15744, Q16548, P11215, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522

MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863
P12429	ANXA3	Annexin A3	P14780	MMP9	Matrix metalloproteinase-9	0.918
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P12429	ANXA3	Annexin A3	P27930	IL1R2	Interleukin-1 receptor type 2	0.865
P12429	ANXA3	Annexin A3	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.784
P12429	ANXA3	Annexin A3	Q16548	BCL2A1	Bcl-2-related protein A1	0.871
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P12429	ANXA3	Annexin A3	P05164	MPO	Myeloperoxidase	0.815
P12429	ANXA3	Annexin A3	P12838	DEFA4	Neutrophil defensin 4	0.899
P12429	ANXA3	Annexin A3	P08246	ELA2	Neutrophil elastase	0.741
P12429	ANXA3	Annexin A3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.74
P12429	ANXA3	Annexin A3	P41182	BCL6	B-cell lymphoma 6 protein	0.845
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P12429	ANXA3	Annexin A3	Q13547	HDAC1	Histone deacetylase 1	-0.765
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P12429	ANXA3	Annexin A3	P12980	LYL1	Protein lyl-1	0.777
P12429	ANXA3	Annexin A3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.863

Hydrocortisone-valerate

Viral carcinogenesis

2.10E-04

Q12933, P42229, Q13547, Q15283, P58876, P62807, Q16778, O60814

TRAF2, STAT5A, HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Hydrocortisone-valerate

Chemical carcinogenesis

1.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Hydrocortisone-valerate

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P15311	VIL2	Ezrin	0.722
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.772
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P46531	NOTCH1	Neurogenic locus notch homolog protein 1	0.706
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P22105	TNXB	Tenascin-X	0.769

Hydrocortisone-valerate

Central carbon metabolism in cancer

1.12E-02

P11413

G6PD

Hydrocortisone-valerate

PD-L1 expression and PD-1 checkpoint pathway in cancer

5.53E-04

P42338, O95267, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730

PIK3CB, RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
O43451	MGAM	Maltase-glucoamylase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.73
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
O43451	MGAM	Maltase-glucoamylase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.79
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
O43451	MGAM	Maltase-glucoamylase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.755
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
O43451	MGAM	Maltase-glucoamylase	P06239	LCK	Tyrosine-protein kinase Lck	-0.748
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
O43451	MGAM	Maltase-glucoamylase	Q04759	PRKCQ	Protein kinase C theta type	-0.777
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
O43451	MGAM	Maltase-glucoamylase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.871
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
O43451	MGAM	Maltase-glucoamylase	P01730	CD4	T-cell surface glycoprotein CD4	-0.724
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P12429	ANXA3	Annexin A3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.77
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P12429	ANXA3	Annexin A3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.877
P12429	ANXA3	Annexin A3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.769
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P12429	ANXA3	Annexin A3	P06239	LCK	Tyrosine-protein kinase Lck	-0.753
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	Q04759	PRKCQ	Protein kinase C theta type	-0.906
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P12429	ANXA3	Annexin A3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.805
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84

Hydrocortisone-valerate

Asthma

1.62E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Hydrocortisone-valerate

Inflammatory bowel disease

1.09E-03

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832
P12429	ANXA3	Annexin A3	O60603	TLR2	Toll-like receptor 2	0.702
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.769
P12429	ANXA3	Annexin A3	Q9UL17	TBX21	T-box transcription factor TBX21	-0.858
P12429	ANXA3	Annexin A3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.832

Hydrocortisone-valerate

Systemic lupus erythematosus

4.80E-06

P09871, Q93077, P58876, P62807, Q16778, O60814, P68431

C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	P09871	C1S	Complement C1s subcomponent	0.744
P17252	PRKCA	Protein kinase C alpha type	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.82
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845

Hydrocortisone-valerate

Graft-versus-host disease

1.76E-02

P13765, P01375, P26715, Q13241

HLA-DOB, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.836
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q14145	KEAP1	Kelch-like ECH-associated protein 1	P01375	TNF	Tumor necrosis factor	-0.844
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84
P12429	ANXA3	Annexin A3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.76
P12429	ANXA3	Annexin A3	P01375	TNF	Tumor necrosis factor	0.832
P12429	ANXA3	Annexin A3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.83
P12429	ANXA3	Annexin A3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.84

Hydrocortisone-valerate