PharmaCoNets of Hydrocodone (SPCN: 15.09 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Hydrocodonehsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Hydrocodonehsa00500Starch and sucrose metabolism9.22E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Hydrocodonehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Hydrocodonehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Hydrocodonehsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Hydrocodonehsa00770Pantothenate and CoA biosynthesis7.90E-033O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Hydrocodonehsa00970Aminoacyl-tRNA biosynthesis1.58E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Hydrocodonehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Hydrocodonehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Hydrocodonehsa01522Endocrine resistance4.51E-022P04637, P42773TP53, CDKN2CMore
Hydrocodonehsa01524Platinum drug resistance1.13E-025P10415, Q13489, P78417, P23025, P43246BCL2, BIRC3, GSTO1, XPA, MSH2More
Hydrocodonehsa03008Ribosome biogenesis in eukaryotes2.60E-035Q9NYH9, P78345, Q9BVP2, O15381, Q9GZY0UTP6, RPP38, GNL3, NVL, NXF2; NXF2BMore
Hydrocodonehsa03013RNA transport2.29E-0413O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1More
Hydrocodonehsa03040Spliceosome5.79E-037Q14562, O43143, O60508, Q99633, Q13595, Q01130, Q9UMS4DHX8, DHX15, CDC40, PRPF18, TRA2A, SFRS2, PRPF19More
Hydrocodonehsa04015Rap1 signaling pathway1.58E-026P20827, P49767, P63261, P25116, P0DP23, P17252EFNA1, VEGFC, ACTG1, F2R, CALM1, PRKCAMore
Hydrocodonehsa04020Calcium signaling pathway1.16E-037Q16566, P17252, O15399, P25116, P0DP23, P23634, P49767CAMK4, PRKCA, GRIN2D, F2R, CALM1, ATP2B4, VEGFCMore
Hydrocodonehsa04024cAMP signaling pathway2.84E-025P0DP23, P23634, Q16566, O15399, P25116CALM1, ATP2B4, CAMK4, GRIN2D, F2RMore
Hydrocodonehsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Hydrocodonehsa04064NF-kappa B signaling pathway4.92E-026P10415, P51617, Q13546, Q9UDY8, Q13077, P24522BCL2, IRAK1, RIPK1, MALT1, TRAF1, GADD45AMore
Hydrocodonehsa04070Phosphatidylinositol signaling system4.07E-024P0DP23, Q14643, O14732, P17252CALM1, ITPR1, IMPA2, PRKCAMore
Hydrocodonehsa04071Sphingolipid signaling pathway1.90E-038P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2More
Hydrocodonehsa04110Cell cycle1.29E-024P30260, P04637, P49918, P42773CDC27, TP53, CDKN1C, CDKN2CMore
Hydrocodonehsa04145Phagosome1.86E-025P63261, Q15080, Q13509, P68371, P27824ACTG1, NCF4, TUBB3, TUBB2C, CANXMore
Hydrocodonehsa04151PI3K-Akt signaling pathway4.57E-023P04637, Q96BR1, P56279TP53, SGK3, TCL1AMore
Hydrocodonehsa04261Adrenergic signaling in cardiomyocytes3.44E-025Q16537, P0DP23, P17252, P10415, P20020PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1More
Hydrocodonehsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Hydrocodonehsa04390Hippo signaling pathway1.47E-025P63261, Q13485, Q9UJU2, O43623, Q13489ACTG1, SMAD4, LEF1, SNAI2, BIRC3More
Hydrocodonehsa04510Focal adhesion3.21E-026Q15942, P17252, Q13489, P10415, P49767, P63261ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1More
Hydrocodonehsa04520Adherens junction3.36E-024Q13485, Q9UJU2, O43623, P63261SMAD4, LEF1, SNAI2, ACTG1More
Hydrocodonehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Hydrocodonehsa04540Gap junction4.76E-023P17252, Q13509, P68371PRKCA, TUBB3, TUBB2CMore
Hydrocodonehsa04612Antigen processing and presentation1.51E-027P13765, P48382, P26715, P26717, Q13241, O43908, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8AMore
Hydrocodonehsa04613Neutrophil extracellular trap formation1.15E-0313P17252, O60603, P08246, Q92769, Q6FI13, Q93077, P62807, P33778, O60814, P68431, P14598, Q15080, P21462PRKCA, TLR2, ELA2, HDAC2, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1More
Hydrocodonehsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Hydrocodonehsa04650Natural killer cell mediated cytotoxicity7.01E-0510P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Hydrocodonehsa04660T cell receptor signaling pathway1.49E-0310P01375, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Hydrocodonehsa04666Fc gamma R-mediated phagocytosis2.22E-024P49006, P06396, P14598, P17252MARCKSL1, GSN, NCF1, PRKCAMore
Hydrocodonehsa04720Long-term potentiation3.70E-045P17252, Q16566, P0DP23, O15399, Q14643PRKCA, CAMK4, CALM1, GRIN2D, ITPR1More
Hydrocodonehsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Hydrocodonehsa04912GnRH signaling pathway4.42E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Hydrocodonehsa04916Melanogenesis3.55E-023P0DP23, Q9UJU2, P17252CALM1, LEF1, PRKCAMore
Hydrocodonehsa04921Oxytocin signaling pathway4.19E-024P0DP23, P17252, Q16566, P63261CALM1, PRKCA, CAMK4, ACTG1More
Hydrocodonehsa04925Aldosterone synthesis and secretion2.90E-046Q14643, P0DP23, P17252, Q16566, P20020, P23634ITPR1, CALM1, PRKCA, CAMK4, ATP2B1, ATP2B4More
Hydrocodonehsa04933AGE-RAGE signaling pathway in diabetic complications3.36E-024Q13485, P10415, P49767, P17252SMAD4, BCL2, VEGFC, PRKCAMore
Hydrocodonehsa04966Collecting duct acid secretion3.15E-022P02730, Q9Y666SLC4A1, SLC12A7More
Hydrocodonehsa04970Salivary secretion8.71E-045Q14643, P20020, P23634, P17252, P0DP23ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1More
Hydrocodonehsa04971Gastric acid secretion4.76E-023P17252, P63261, P0DP23PRKCA, ACTG1, CALM1More
Hydrocodonehsa04972Pancreatic secretion1.00E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Hydrocodonehsa04978Mineral absorption3.94E-022P23634, Q9BXS9ATP2B4, SLC26A6More
Hydrocodonehsa05014Amyotrophic lateral sclerosis4.31E-027O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2BMore
Hydrocodonehsa05031Amphetamine addiction1.49E-024O15399, P0DP23, Q16566, P17252GRIN2D, CALM1, CAMK4, PRKCAMore
Hydrocodonehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Hydrocodonehsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Hydrocodonehsa05132Salmonella infection2.12E-0413P51617, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371IRAK1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2CMore
Hydrocodonehsa05133Pertussis2.52E-023P0DP23, P23528, P09871CALM1, CFL1, C1SMore
Hydrocodonehsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Hydrocodonehsa05140Leishmaniasis1.56E-025P14598, O60603, P49006, P51617, Q15080NCF1, TLR2, MARCKSL1, IRAK1, NCF4More
Hydrocodonehsa05144Malaria1.64E-035P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Hydrocodonehsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Hydrocodonehsa05168Herpes simplex virus 1 infection1.94E-029Q9UKJ0, P01568, Q9GZY0, Q01130, Q13489, Q13398, Q03923, Q9UDV6, P10415PILRB, IFNA21, NXF2; NXF2B, SFRS2, BIRC3, ZNF211, ZNF85, ZNF212, BCL2More
Hydrocodonehsa05169Epstein-Barr virus infection2.54E-028Q92769, P04637, Q13546, P10415, P24522, O60603, P51617, P09693HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, IRAK1, CD3GMore
Hydrocodonehsa05170Human immunodeficiency virus 1 infection6.54E-039P0DP23, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5CALM1, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2More
Hydrocodonehsa05200Pathways in cancer1.51E-0212Q9UJU2, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P25116, P78417, P0DP23, P01568LEF1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, F2R, GSTO1, CALM1, IFNA21More
Hydrocodonehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Hydrocodonehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Hydrocodonehsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Hydrocodonehsa05214Glioma8.71E-045P0DP23, Q16566, P17252, P04637, P24522CALM1, CAMK4, PRKCA, TP53, GADD45AMore
Hydrocodonehsa05216Thyroid cancer1.85E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Hydrocodonehsa05217Basal cell carcinoma4.42E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Hydrocodonehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Hydrocodonehsa05418Fluid shear stress and atherosclerosis2.49E-0311Q16539, P78417, P10599, P14780, P01375, P63261, P10415, P14778, P27930, P0DP23, Q92974MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2More

Community members of Hydrocodone (SDC: 1.60)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P51684CCR6CNoneC chemokine receptor type 6Predicted00.0850.17410.33040.7212
P46091GPR1ChemerinNonelike receptor 2Predicted00.24760.137200.3982
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)