PharmaCoNets of Histrelin (SPCN: 8.49 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Histrelinhsa00072Synthesis and degradation of ketone bodies2.78E-021Q01581HMGCS1More
Histrelinhsa00220Arginine biosynthesis1.21E-021P15104GLULMore
Histrelinhsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Histrelinhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Histrelinhsa00900Terpenoid backbone biosynthesis1.40E-021Q01581HMGCS1More
Histrelinhsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Histrelinhsa01100Metabolic pathways4.11E-027P30041, P20839, P08237, Q86XP1, Q9UHK6, Q86VZ5, Q9NVH6PRDX6, IMPDH1, PFKM, DGKH, AMACR, SGMS1, TMLHEMore
Histrelinhsa01200Carbon metabolism4.06E-025P37837, O14521, P50213, P60891, Q02252TALDO1, SDHD, IDH3A, PRPS1, ALDH6A1More
Histrelinhsa01230Biosynthesis of amino acids5.53E-032P15104, P37837GLUL, TALDO1More
Histrelinhsa01521EGFR tyrosine kinase inhibitor resistance2.18E-022P49841, Q9NRA1GSK3B, PDGFCMore
Histrelinhsa03013RNA transport4.73E-029P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, Q9Y6A5NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, TACC3More
Histrelinhsa04080Neuroactive ligand-receptor interaction4.15E-022Q01726, P41968MC1R, MC3RMore
Histrelinhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Histrelinhsa04142Lysosome2.64E-022Q99437, P25774ATP6V0B, CTSSMore
Histrelinhsa04145Phagosome3.11E-022Q99437, P25774ATP6V0B, CTSSMore
Histrelinhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Histrelinhsa04330Notch signaling pathway7.49E-032Q92542, P49768NCSTN, PSEN1More
Histrelinhsa04613Neutrophil extracellular trap formation9.53E-0313P17252, O60603, P08246, Q9UM07, Q92769, Q6FI13, P14598, Q15080, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, ELA2, PADI4, HDAC2, H2AC18; H2AC19, NCF1, NCF4, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Histrelinhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Histrelinhsa04912GnRH signaling pathway3.39E-024P17252, Q16539, Q9Y6R4, Q14643PRKCA, MAPK14, MAP3K4, ITPR1More
Histrelinhsa04916Melanogenesis2.18E-022P49841, Q01726GSK3B, MC1RMore
Histrelinhsa04919Thyroid hormone signaling pathway3.71E-022P26678, P08237PLN, PFKMMore
Histrelinhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Histrelinhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Histrelinhsa04972Pancreatic secretion3.86E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Histrelinhsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Histrelinhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Histrelinhsa05152Tuberculosis4.16E-022Q99437, P25774ATP6V0B, CTSSMore
Histrelinhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Histrelinhsa05222Small cell lung cancer4.26E-026P10826, Q13489, P10415, Q13077, O00463, P24522RARB, BIRC3, BCL2, TRAF1, TRAF5, GADD45AMore
Histrelinhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Histrelinhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Histrelinhsa05415Diabetic cardiomyopathy3.19E-027P17252, P14598, Q15080, Q16718, O14521, Q16539, P14780PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, MMP9More

Community members of Histrelin (SDC: 2.37)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O95931CBX7Chromobox protein homolog 7Predicted00.41860.181600.5726
O60603TLR2TollNonelike receptor 2Predicted10.21260.080511.2673
P41968MC3RMelanocortin receptor 3Predicted10.22350.263700.6392
Q01726MC1RMelanocyteNonestimulating hormone receptorPredicted10.0470.23750.0110.5095
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)