PharmaCoNets of Histamine (SPCN: 5.59 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Histaminehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Histaminehsa00500Starch and sucrose metabolism2.15E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Histaminehsa00531Glycosaminoglycan degradation8.18E-042P15586, P34059GNS, GALNSMore
Histaminehsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate2.92E-021Q9Y2C2USTMore
Histaminehsa00970Aminoacyl-tRNA biosynthesis9.57E-033O95363, P54136, P14868FARS2, RARS1, DARSMore
Histaminehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Histaminehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Histaminehsa03008Ribosome biogenesis in eukaryotes2.06E-022Q9NYH9, Q9BVP2UTP6, GNL3More
Histaminehsa04061Viral protein interaction with cytokine and cytokine receptor2.91E-026P09341, P25024, P25025, P47992, Q9UBD3, P01375CXCL1, CXCR1, CXCR2, XCL1, XCL2, TNFMore
Histaminehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Histaminehsa04080Neuroactive ligand-receptor interaction7.88E-0411P08311, P28472, Q15722, P21453, Q9H228, P43657, P21462, P21730, P14416, P07550, P35318CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY5, FPR1, C5AR1, DRD2, ADRB2, ADMMore
Histaminehsa04142Lysosome1.14E-023P43234, P15586, P34059CTSO, GNS, GALNSMore
Histaminehsa04210Apoptosis9.18E-034P04637, P24522, P43234, P63261TP53, GADD45A, CTSO, ACTG1More
Histaminehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Histaminehsa04612Antigen processing and presentation5.66E-058P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Histaminehsa04613Neutrophil extracellular trap formation1.31E-0211O60603, P05164, Q9UM07, Q13547, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, PADI4, HDAC1, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Histaminehsa04650Natural killer cell mediated cytotoxicity2.83E-059P01375, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Histaminehsa04657IL-17 signaling pathway1.64E-038O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Histaminehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Histaminehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Histaminehsa04742Taste transduction1.01E-021P30939HTR1FMore
Histaminehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Histaminehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Histaminehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Histaminehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Histaminehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Histaminehsa04976Bile secretion3.87E-023O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Histaminehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Histaminehsa05120Epithelial cell signaling in Helicobacter pylori infection3.87E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Histaminehsa05140Leishmaniasis4.59E-025O75015, O60603, P01375, Q16539, Q15080FCGR3B, TLR2, TNF, MAPK14, NCF4More
Histaminehsa05144Malaria1.38E-034O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Histaminehsa05146Amoebiasis7.83E-0510P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, CTSGMore
Histaminehsa05205Proteoglycans in cancer4.79E-038P63261, P04637, P14780, P01375, P23588, Q06124, Q13635, P22694ACTG1, TP53, MMP9, TNF, EIF4B, PTPN11, PTCH1, PRKACBMore
Histaminehsa05211Renal cell carcinoma7.75E-032Q06124, Q99814PTPN11, EPAS1More
Histaminehsa05212Pancreatic cancer2.60E-022P04637, P24522TP53, GADD45AMore
Histaminehsa05213Endometrial cancer2.60E-022P04637, P24522TP53, GADD45AMore
Histaminehsa05214Glioma2.60E-022P04637, P24522TP53, GADD45AMore
Histaminehsa05216Thyroid cancer1.14E-022P04637, P24522TP53, GADD45AMore
Histaminehsa05217Basal cell carcinoma2.06E-022P04637, P24522TP53, GADD45AMore
Histaminehsa05218Melanoma1.14E-022P04637, P24522TP53, GADD45AMore
Histaminehsa05220Chronic myeloid leukemia7.90E-033Q06124, P04637, P24522PTPN11, TP53, GADD45AMore
Histaminehsa05223Non-small cell lung cancer3.19E-022P04637, P24522TP53, GADD45AMore
Histaminehsa05224Breast cancer4.51E-022P04637, P24522TP53, GADD45AMore
Histaminehsa05225Hepatocellular carcinoma3.30E-023P04637, P24522, P63261TP53, GADD45A, ACTG1More
Histaminehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Histaminehsa05332Graft-versus-host disease8.79E-033P01375, P26715, Q13241TNF, KLRC1, KLRD1More
Histaminehsa05418Fluid shear stress and atherosclerosis4.81E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Histamine (SDC: 0.97)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
Q9Y4K0LOXL2Lysyl oxidase homolog 2Predicted00.02690.119800.253
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)