PharmaCoNets

PharmaCoNets of Hexylcaine (S_PCN: 95.81 )

Hexylcaine regulated-network (S_DN: 18.04)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Hexylcaine

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Hexylcaine

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Hexylcaine

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Hexylcaine

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Hexylcaine

hsa00220

Arginine biosynthesis

4.88E-02

P49448

GLUD2

Hexylcaine

hsa00250

Alanine, aspartate and glutamate metabolism

4.88E-02

P49448

GLUD2

Hexylcaine

hsa00471

D-Glutamine and D-glutamate metabolism

1.65E-02

P49448

GLUD2

Hexylcaine

hsa00480

Glutathione metabolism

3.29E-04

Q9UJ14, Q16772, P09211, P30041

GGTL3, GSTA3, GSTP1, PRDX6

Hexylcaine

hsa00500

Starch and sucrose metabolism

6.17E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Hexylcaine

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Hexylcaine

hsa00630

Glyoxylate and dicarboxylate metabolism

1.32E-02

P40925, P15104

MDH1, GLUL

Hexylcaine

hsa00730

Thiamine metabolism

2.27E-02

P05186, P24666

ALPL, ACP1

Hexylcaine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Hexylcaine

hsa00910

Nitrogen metabolism

4.88E-02

P49448

GLUD2

Hexylcaine

hsa00980

Metabolism of xenobiotics by cytochrome P450

5.46E-03

Q16772, P09211

GSTA3, GSTP1

Hexylcaine

hsa00982

Drug metabolism - cytochrome P450

1.06E-02

Q16772, P09211

GSTA3, GSTP1

Hexylcaine

hsa00983

Drug metabolism - other enzymes

1.92E-03

P04183, P32320, P05164, Q16772, P09211

TK1, CDA, MPO, GSTA3, GSTP1

Hexylcaine

hsa01100

Metabolic pathways

8.43E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1

Hexylcaine

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Hexylcaine

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Hexylcaine

hsa01524

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Hexylcaine

hsa02010

ABC transporters

2.17E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Hexylcaine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Hexylcaine

hsa03040

Spliceosome

4.19E-04

Q14562, O43143, O60508, P08579, Q07955, Q01130, Q13243, P11142, O43447, O75643

DHX8, DHX15, CDC40, SNRPB2, SFRS1, SFRS2, SFRS5, HSPA8, PPIH, ASCC3L1

Hexylcaine

hsa03060

Protein export

3.28E-02

Q15070

OXA1L

Hexylcaine

hsa04012

ErbB signaling pathway

1.34E-02

P16333, P19174, P42338, P01106

NCK1, PLCG1, PIK3CB, MYC

Hexylcaine

hsa04014

Ras signaling pathway

2.92E-04

P42338, P20827, Q9NRA1, P49767, Q13009, P0DP23, P62873, P63218, P50151, P19174

PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1

Hexylcaine

hsa04015

Rap1 signaling pathway

4.83E-03

P20827, Q9NRA1, P49767, P11215, Q13009, P42338, P0DP23, P19174

EFNA1, PDGFC, VEGFC, ITGAM, TIAM1, PIK3CB, CALM1, PLCG1

Hexylcaine

hsa04020

Calcium signaling pathway

2.61E-02

P27987, P21796, P19174, P0DP23, Q9NRA1, P49767

ITPKB, VDAC1, PLCG1, CALM1, PDGFC, VEGFC

Hexylcaine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Hexylcaine

hsa04062

Chemokine signaling pathway

2.81E-05

P25024, P25025, P09341, P19875, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q13009, P14598, P42224, P25963

CXCR1, CXCR2, CXCL1, CXCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, TIAM1, NCF1, STAT1, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43250	GRK6	G protein-coupled receptor kinase 6	-0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711

Hexylcaine

hsa04064

NF-kappa B signaling pathway

1.74E-05

P10415, O00463, P14778, P19174, Q04759, Q9UDY8, Q16548, P06239, Q13315, P24522, P09341, P19875, Q06643

BCL2, TRAF5, IL1R1, PLCG1, PRKCQ, MALT1, BCL2A1, LCK, ATM, GADD45A, CXCL1, CXCL2, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P05164	MPO	Myeloperoxidase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P05164	MPO	Myeloperoxidase	O00463	TRAF5	TNF receptor-associated factor 5	-0.821
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P05164	MPO	Myeloperoxidase	Q04759	PRKCQ	Protein kinase C theta type	-0.88
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P05164	MPO	Myeloperoxidase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P05164	MPO	Myeloperoxidase	Q16548	BCL2A1	Bcl-2-related protein A1	0.782
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P05164	MPO	Myeloperoxidase	Q13315	ATM	Serine-protein kinase ATM	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P05164	MPO	Myeloperoxidase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P05164	MPO	Myeloperoxidase	P09341	CXCL1	Growth-regulated alpha protein	0.806
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74

Hexylcaine

hsa04070

Phosphatidylinositol signaling system

1.12E-02

P19174, P0DP23, P42338, P23743, P27987

PLCG1, CALM1, PIK3CB, DGKA, ITPKB

Hexylcaine

hsa04071

Sphingolipid signaling pathway

4.27E-05

P21453, Q9H228, P01375, Q13362, Q9BX95, P10415

S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2

Hexylcaine

hsa04072

Phospholipase D signaling pathway

5.49E-03

P42338, P43657, P25024, P25025, P19174, Q14344, P23743, Q9NRA1

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, GNA13, DGKA, PDGFC

Hexylcaine

hsa04080

Neuroactive ligand-receptor interaction

7.54E-05

P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2

Hexylcaine

hsa04115

p53 signaling pathway

3.98E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Hexylcaine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Hexylcaine

hsa04130

SNARE interactions in vesicular transport

1.27E-02

O15155

BET1

Hexylcaine

hsa04140

Autophagy - animal

3.19E-02

P22694, Q14643, P10415, Q04759

PRKACB, ITPR1, BCL2, PRKCQ

Hexylcaine

hsa04145

Phagosome

4.48E-02

Q15080, P05164, O60603, P35443, P13765

NCF4, MPO, TLR2, THBS4, HLA-DOB

Hexylcaine

hsa04151

PI3K-Akt signaling pathway

5.62E-03

P42338, P01106, P20827, Q9NRA1, P49767, P08238, P62873, P63218, P50151, O15335, P14784, P01568

PIK3CB, MYC, EFNA1, PDGFC, VEGFC, HSP90AB1, GNB1, GNG5, GNG10, CHAD, IL2RB, IFNA21

Hexylcaine

hsa04152

AMPK signaling pathway

2.34E-02

Q96EB6, P36956

SIRT1, SREBF1

Hexylcaine

hsa04210

Apoptosis

3.83E-03

Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1

Hexylcaine

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Hexylcaine

hsa04217

Necroptosis

2.34E-02

P01375, P48023, Q14765, Q99878

TNF, FASLG, STAT4, H2AC14

Hexylcaine

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Hexylcaine

hsa04340

Hedgehog signaling pathway

3.09E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Hexylcaine

hsa04360

Axon guidance

2.87E-02

P16333, P20827, O95631, P42338, P19174

NCK1, EFNA1, NTN1, PIK3CB, PLCG1

Hexylcaine

hsa04371

Apelin signaling pathway

2.41E-03

P62873, P63218, P50151, Q13370, Q14814, Q14344, P0DP23

GNB1, GNG5, GNG10, PDE3B, MEF2D, GNA13, CALM1

Hexylcaine

hsa04380

Osteoclast differentiation

1.02E-02

Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149

GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2

Hexylcaine

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Hexylcaine

hsa04612

Antigen processing and presentation

3.32E-05

P13765, P48382, Q14953, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Hexylcaine

hsa04613

Neutrophil extracellular trap formation

6.35E-04

P42338, P19174, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q93077, P62807, Q93079, P68431, P21796, P14598, Q15080, P20160, P08311, P21730, O43315, Q16539

PIK3CB, PLCG1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC9, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, NCF4, AZU1, CTSG, C5AR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Hexylcaine

hsa04620

Toll-like receptor signaling pathway

4.00E-02

P01568, P42224, P25963, P42338

IFNA21, STAT1, NFKBIA, PIK3CB

Hexylcaine

hsa04623

Cytosolic DNA-sensing pathway

3.67E-02

P01568, P25963

IFNA21, NFKBIA

Hexylcaine

hsa04625

C-type lectin receptor signaling pathway

2.21E-03

Q9ULY5, P42224, P20749, P25963, P01375, P42338, P0DP23, Q16539

CLEC4E, STAT1, BCL3, NFKBIA, TNF, PIK3CB, CALM1, MAPK14

Hexylcaine

hsa04640

Hematopoietic cell lineage

1.37E-02

P14778, P27930, P11215, P25063, P07766, P01732, P09564

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7

Hexylcaine

hsa04650

Natural killer cell mediated cytotoxicity

8.39E-07

P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q14953, P26715

PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Hexylcaine

hsa04657

IL-17 signaling pathway

8.98E-04

O00463, Q16539, P49841, P19875, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL2, MMP9, LCN2, TNF

Hexylcaine

hsa04658

Th1 and Th2 cell differentiation

2.87E-08

P25963, Q04759, P07766, P20963, P09693, P19174, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

NFKBIA, PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Hexylcaine

hsa04659

Th17 cell differentiation

8.10E-06

P25963, Q04759, P19174, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Hexylcaine

hsa04660

T cell receptor signaling pathway

1.09E-04

Q9UDY8, Q04759, P42338, P10747, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239

MALT1, PRKCQ, PIK3CB, CD28, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK

Hexylcaine

hsa04662

B cell receptor signaling pathway

1.12E-02

P25963, P42338, P07948, P21854, Q8N149

NFKBIA, PIK3CB, LYN, CD72, LILRA2

Hexylcaine

hsa04664

Fc epsilon RI signaling pathway

1.29E-03

P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917

TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5

Hexylcaine

hsa04666

Fc gamma R-mediated phagocytosis

2.92E-02

P07948, P42338, P19174, P14598

LYN, PIK3CB, PLCG1, NCF1

Hexylcaine

hsa04668

TNF signaling pathway

2.12E-03

P01375, O00463, Q16539, P18848, P19875, P20749, P14780

TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9

Hexylcaine

hsa04713

Circadian entrainment

4.00E-02

P0DP23, P62873, P63218, P50151

CALM1, GNB1, GNG5, GNG10

Hexylcaine

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Hexylcaine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Hexylcaine

hsa04724

Glutamatergic synapse

2.92E-02

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Hexylcaine

hsa04725

Cholinergic synapse

3.51E-03

P22694, Q14643, P62873, P63218, P50151, P18848, P42338, P10415

PRKACB, ITPR1, GNB1, GNG5, GNG10, ATF4, PIK3CB, BCL2

Hexylcaine

hsa04727

GABAergic synapse

8.14E-03

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Hexylcaine

hsa04744

Phototransduction

1.32E-02

P62873, P0DP23

GNB1, CALM1

Hexylcaine

hsa04750

Inflammatory mediator regulation of TRP channels

8.12E-04

P14778, P19174, P42338, P24723, Q04759, P0DP23

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1

Hexylcaine

hsa04810

Regulation of actin cytoskeleton

2.61E-02

P12814, Q13009, P42338, P11215, Q14344, Q9NRA1

ACTN1, TIAM1, PIK3CB, ITGAM, GNA13, PDGFC

Hexylcaine

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Hexylcaine

hsa04914

Progesterone-mediated oocyte maturation

4.00E-02

P42338, Q13370, P30304, P08238

PIK3CB, PDE3B, CDC25A, HSP90AB1

Hexylcaine

hsa04915

Estrogen signaling pathway

2.96E-02

P14780, P22694, P18848, Q14643, P10415

MMP9, PRKACB, ATF4, ITPR1, BCL2

Hexylcaine

hsa04918

Thyroid hormone synthesis

3.50E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Hexylcaine

hsa04922

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Hexylcaine

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Hexylcaine

hsa04924

Renin secretion

8.77E-04

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Hexylcaine

hsa04926

Relaxin signaling pathway

6.11E-04

P25963, P42338, P62873, P63218, P50151, P18848, P22694, P49767, P14780, P30679

NFKBIA, PIK3CB, GNB1, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, GNA15

Hexylcaine

hsa04927

Cortisol synthesis and secretion

4.44E-04

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Hexylcaine

hsa04928

Parathyroid hormone synthesis, secretion and action

2.33E-03

Q14643, P22694, P23771, P18848, P10415

ITPR1, PRKACB, GATA3, ATF4, BCL2

Hexylcaine

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Hexylcaine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Hexylcaine

hsa04964

Proximal tubule bicarbonate reclamation

4.53E-03

P00918, P49448

CA2, GLUD2

Hexylcaine

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Hexylcaine

hsa04970

Salivary secretion

1.91E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

Hexylcaine

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Hexylcaine

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Hexylcaine

hsa05012

Parkinson disease

4.01E-02

P21796, P60604, P19174, P0DP23, Q71U36, Q13509

VDAC1, UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3

Hexylcaine

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Hexylcaine

hsa05022

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Hexylcaine

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Hexylcaine

hsa05032

Morphine addiction

7.60E-03

P62873, P63218, P50151, Q13370, P43250

GNB1, GNG5, GNG10, PDE3B, GRK6

Hexylcaine

hsa05034

Alcoholism

6.32E-03

Q13547, P0DP23, P62873, P63218, P50151, P62807, Q93079

HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2BC, H2BC9

Hexylcaine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.78E-03

P09341, P19875, P19174, P25024, P25025

CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Hexylcaine

hsa05132

Salmonella infection

2.36E-02

P25963, P08238, P01106, P42338, O75369, Q71U36, Q13509, P49754

NFKBIA, HSP90AB1, MYC, PIK3CB, FLNB, TUBA1A, TUBB3, VPS41

Hexylcaine

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Hexylcaine

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Hexylcaine

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Hexylcaine

hsa05144

Malaria

1.44E-03

P69905, P68871, P01375, P35443, P26718

HBA2, HBB, TNF, THBS4, KLRK1

Hexylcaine

hsa05146

Amoebiasis

2.05E-05

P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814

CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1

Hexylcaine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Hexylcaine

hsa05162

Measles

1.84E-02

P01568, P25963, P42224, P14784, P07766, P42338, P11142

IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8

Hexylcaine

hsa05163

Human cytomegalovirus infection

4.95E-05

P42338, P01375, P25963, P62873, P63218, P50151, P0DP23, Q14344, P49841, P01106, P14778, P25025, Q16539, O00463, P30101, P01568

PIK3CB, TNF, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, GSK3B, MYC, IL1R1, CXCR2, MAPK14, TRAF5, PDIA3, IFNA21

Hexylcaine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

7.49E-05

P01568, P42224, P25963, P42338, P62873, P63218, P50151, P19174, P07948, P01106, P0DP23

IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, PLCG1, LYN, MYC, CALM1

Hexylcaine

hsa05168

Herpes simplex virus 1 infection

4.57E-02

P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q13398, O75820

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF211, ZNF189

Hexylcaine

hsa05169

Epstein-Barr virus infection

1.08E-03

P01106, Q13547, P25963, P42338, P07948, P30101, Q13761, O75293, P42224, P01568, P07766

MYC, HDAC1, NFKBIA, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, STAT1, IFNA21, CD3E

Hexylcaine

hsa05170

Human immunodeficiency virus 1 infection

3.24E-03

P42338, P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174, P07766

PIK3CB, GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1, CD3E

Hexylcaine

hsa05200

Pathways in cancer

1.82E-03

P42338, P08238, P42224, P25963, P19174, P01106, P43246, Q13547, P49767, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784

PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, HDAC1, VEGFC, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB

Hexylcaine

hsa05202

Transcriptional misregulation in cancer

1.63E-03

Q12778, Q15532, Q13315, P14780, Q15744, Q16548, O15550, P05164, P12838, P08246, Q9C0K0, P24522

FOXO1, SS18, ATM, MMP9, CEBPE, BCL2A1, UTX, MPO, DEFA4, ELA2, BCL11B, GADD45A

Hexylcaine

hsa05203

Viral carcinogenesis

2.74E-04

Q12933, P42229, P42338, P06746, P07948, P29083, Q13547, Q15283, P12814, P25963, P62807, Q93079

TRAF2, STAT5A, PIK3CB, POLB, LYN, GTF2E1, HDAC1, RASA2, ACTN1, NFKBIA, HIST1H2BC, H2BC9

Hexylcaine

hsa05204

Chemical carcinogenesis

5.46E-03

Q16772, P09211

GSTA3, GSTP1

Hexylcaine

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Hexylcaine

hsa05206

MicroRNAs in cancer

2.79E-02

P30304, P09493, P01106, P42338, Q13547, P20827, P19174

CDC25A, TPM1, MYC, PIK3CB, HDAC1, EFNA1, PLCG1

Hexylcaine

hsa05214

Glioma

1.34E-02

P0DP23, P42338, P19174, O75293

CALM1, PIK3CB, PLCG1, GADD45B

Hexylcaine

hsa05218

Melanoma

2.31E-02

Q9NRA1, P42338, O75293

PDGFC, PIK3CB, GADD45B

Hexylcaine

hsa05220

Chronic myeloid leukemia

2.17E-02

Q13547, P01106, P25963, P42338, O75293

HDAC1, MYC, NFKBIA, PIK3CB, GADD45B

Hexylcaine

hsa05231

Choline metabolism in cancer

2.92E-03

P42338, Q9NRA1, Q9Y259, P19174, P23743

PIK3CB, PDGFC, CHKB, PLCG1, DGKA

Hexylcaine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

7.96E-05

P25963, P42338, P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759

NFKBIA, PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ

Hexylcaine

hsa05321

Inflammatory bowel disease

5.03E-06

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Hexylcaine

hsa05323

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Hexylcaine

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Hexylcaine

hsa05332

Graft-versus-host disease

1.92E-07

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Hexylcaine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Hexylcaine

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Hexylcaine

hsa05418

Fluid shear stress and atherosclerosis

1.08E-03

Q16539, Q14145, P10599, P14780, P01375, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2

Community members of Hexylcaine (S_DC: 5.31)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

Q9HB89

NMUR1

NeuromedinNoneU receptor 1

Predicted

0.0024

0.303

0.6072

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P42330

AKR1C3

AldoNoneketo reductase family 1 member C3

Predicted

0.4017

0.8348

0.1748

2.0453

P15121

AKR1B1

AldoNoneketo reductase family 1 member B1

Predicted

0.5683

0.629

0.214

1.7562

P05164

MPO

Myeloperoxidase

Predicted

0.2035

0.5368

0.5502

1.7255

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

P40925

MDH1

Malate dehydrogenase, cytoplasmic

Predicted

0.3566

0.2746

0.2426

0.97

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

Q86W56

PARG

Poly(ADPNoneribose) glycohydrolase

Predicted

0.0358

0.0441

0.106

PharmaCoNets of Hexylcaine (SPCN: 95.81 )

Hexylcaine regulated-network (SDN: 18.04)

Community members of Hexylcaine (SDC: 5.31)

PharmaCoNets of Hexylcaine (S_PCN: 95.81 )

Hexylcaine regulated-network (S_DN: 18.04)

Community members of Hexylcaine (S_DC: 5.31)